pseudomembrnösen Kolitis. C. difficiole produziert drei Enterotoxine, Toxin A (tcdA), Toxin B (TcdB) sowie das C. difficile Toxin (CDT). TcdA (307 kDa) und TcdB (270 kDa) sind große, einkettige Proteintoxine, die [...] Forschung (1) Toxin binds to (non-internalizing) binding receptors. (2) The binding receptors form a heterodimer with an internalizing receptor. (3) The toxin is released from the binding receptor, allowing [...] in ihre Zielzellen selbst einschleusen. In der Zelle mono-O-glucosylieren (damit inaktivieren) TcdA und TcdB niedermolekulare GTP bindende Proteine der Rho- und Ras-Familien, in dessen Folge der Barr

Kane SR, Cooray A, Behrens K , Heidersbach A, Kueh AJ, Pal M, Wilcox S, Tai L, Alexander WS, Visvader JE, Nutt SL, Strasser A, Haley B, Zhao Q, Kelly GL, Herold MJ. (2022) Generation of a CRISPR activation [...] interactions. Blood 127(26): 3369-81. Chien W, Sun QY, Ding LW, Mayakonda A, Takao S, Liu L, Lim SL, Tan KT, Garg M, De Sousa Maria Varela A, Xiao J, Jacob N, Behrens K , Stocking C, Lill M, Madan V, Hattori [...] molecular mechanisms driving the initiation and progression of myeloproliferative neoplasms (MPN), with a focus on how dysregulated thrombopoietin/MPL signaling in malignant hematopoietic stem and progenitor

print. DOI: 10.1016/j.bbr.2025.115428 Stenzel M, Alam M, Witte M, Jelinek J, Armbrecht N, Armstrong A, Kral A, Krauss JK, Land R, Schwabe K, Johne M. Exploring the cognitive effects of hearing loss in adult [...] Krauss JK, Scheper V, Kral A, Schwabe K. Processing of auditory information in forebrain regions after hearing loss in adulthood: Behavioral and electrophysiological studies in a rat model. Front Neurosci [...] Jan 9;564:97-109. DOI: 10.1016/j.neuroscience.2024.11.010 Jelinek J, Johne M, Alam M, Krauss JK, Kral A, Schwabe K. Hearing loss in juvenile rats leads to excessive play fighting and hyperactivity, mild cognitive

online on January 31, 2015. doi: 10.1007/s11019-015-9623-z Alpinar-Sencan, Z. (2014). “A Social Understanding of Dignity: A Promising Approach in the Organ Selling Debate.” Bioethica Forum. 7(4): 148–54. Alpinar [...] M. Ramšak, P. Łuków, A. Muzur, F. Steger (eds.). Applied Ethics – Medicine Series . Freiburg: Karl Alber Verlag, 155-77. Alpinar-Sencan, Z. (2021). “Selling Organs: Dignity as a Further Concern”. In: [...] of a Scientific Philosopher Yaman Örs ). Z. Alpınar (Ed.). Ankara: Efil Yayinevi. Konferenzbeiträge Alpinar, Z. (2012). “Bir Bilimsel Felsefeci Olarak Yaman Örs’ün Etik ve Biyoetik’e Yaklaşımı” (A Scientific

Gramann, M. A. Schulleitung / Lehrlogopäde dbl / Fachbereich Stimmstörungen, M.A. Sonderpädagogik (SKT) Peter Gramann, M. A. Schulleitung, Lehrlogopäde [dbl], Fachbereich Stimmstörungen M. A. Sonderpädagogik [...] Laryngektomie Birte Ripken, M. A. Lehrlogopädin dbl / zertifizierte Stottertherapeutin (ivs) / Fachbereich: Redeflussstörungen Birte Ripken, M. A. Lehrlogopädin [dbl] M. A. Erwachsenenbildung Fachbereich [...] Bereich Kindersprache Therese Wegener, M. A. Lehrlogopädin dbl / Fachbereich: Neurologische Störungsbilder © Anna Junge Therese Wegener, M. A. Lehrlogopädin [dbl] M. A. Erwachsenenbildung Fachbereich: Neurologische

der Born J, Markefke S, Bauer E, von Wick A, Epping J, von Maltzahn N, Heyn-Schmidt I, Grams L, Homeyer D, Kerling A, Stiesch M, Tegtbur U, Haverich A, Melk A (2020) Gesundheit und Fitness von deutschen [...] lins B, Claas F, Dipchand A I, Eifert S, Eiz-Vesper B, Epping J, Falk C S, Foster B, Geyer S, Gjertson D, Greer M, Haubitz M, Lau A, Maecker-Kolhoff B, Memaran N, Messner H A, Ostendorf K, Samuel U, Schmidt [...] 15 Melk A, Schmidt B M W, Geyer S, Epping J (2020) Sex disparities in dialysis initiation, access to waitlist, transplantation and transplant outcome in German patients with renal disease-A population

Bauersachs J, Haverich A. Eur J Cardiothorac Surg. 2021 Jun 14;59(6):1155-1163. 2. Left Ventricular Assist Devices for Advanced Heart Failure. Schmitto JD, Rojas SV, Haverich A. N Engl J Med. 2017 May [...] ventricular assist device thrombosis. Schmitto JD, Avsar M, Haverich A. N Engl J Med. 2014 Apr 10;370(15):1463-4. 4. Long-term evaluation of a fully magnetically levitated circulatory support device for advanced [...] dieser AG. Ausgewählte Publikationen 1. Five-year outcomes of patients supported with HeartMate 3: a single-centre experience. Schmitto JD, Mariani S, Li T, Dogan G, Hanke JS, Bara C, Pya Y, Zimpfer D

PhD from MHH in 2015. Subsequently, she joined the group of Dr. Lachmann as a postdoctoral fellow. From 2017-2020 she was also a research fellow at the Dana Farber Cancer Institute (DFCI), Harvard Medical [...] the group of Prof. Dr. Lachmann as a postdoctoral fellow. Main research interests : iPSCs, macrophages, primary immunodeficiencies Daniela Paasch Dr. Daniela Paasch is a trained technician and received her [...] research group of Prof. Dr. Lachmann as a postdoctoral researcher, where she is currently continuing her research on chronic and inflammatory liver disease with a focus on cell therapy and regenerative

disseminate latest findings, TECHNOBEAT hosted a workshop at this year's GSCN Conference. Hosted by Robert zweigerdt (MHH) and Dirk Strunk (PMU) the session started with a special keynote by Prof. Michael Laflamme [...] Community Day—A Review On April 24, 2018, the second international Stem Cell Community Day took place in Düsseldorf, Germany. More than 150 participants from 16 countries—22 of them presenting a poster—attended [...] “fills a gap in the European conference landscape”. The program covered some of the most important challenges in stem cell bioprocessing today: Process design, scale-up, and product safety. After a warm

Across a Decade of the Visceral Medicine Congress in Germany. Zeitschrift für Gastroenterologie 2025 (efirst). doi:10.1055/a-2701-1372 Ar E, Solomonidou I, Lenzen H, Wiestler M , ..., Bokemeyer A. Long-Term [...] "Association of a common AKAP9 variant with breast cancer risk: a collaborative analysis." J Natl Cancer Inst 100(6): 437-442. Frank, B., S. H. Rigas, J. L. Bermejo, Wiestler M ., … , A. Cox and B. Burwinkel [...] General Population: A Qualitative Analysis. Nutrients 2024; 16. DOI: 10.3390/nu16172954 Peyrin-Biroulet L, Rahier JF, Kirchgesner J, … Beaugerie L; I-CARE Collaborator Group . I-CARE, a European Prospective