Studium und akademische Ausbildung

• 2006 Außerplanmäßiger Professor, Medizinische Hochschule Hannover
• 2001 Habilitation und Venia Legendi für Biochemie; Medizinische Hochschule Hannover
• 1993 Promotion zum Doktor rer.nat., Universität Bremen
• 1989 Diplom Biologie
• 1985 - 1989 Studium-2    Biologie, Universität Bremen (Vordiplom)
• 1983 - 1985 Studium-1    Chemie, Universität Bremen (Vordiplom)

Wissenschaftlicher Werdegang

• 2025 -                       
• 2006 – 2025 Arbeitsgruppenleiter am Dr. Senckenbergischen Institut für Anatomie 3 (Zelluläre und Molekulare Anatomie) und 2 (Experimentelle Neurobiologie) der Goethe Universität, Frankfurt
• 05/2005-12/2005 Stellvertretender Leiter der Forschungsgruppe für klinische und experimentelle Peptidforschung, Medizinische Hochschule Hannover
• 2000 – 2005 Abteilungsleiter IPF Pharmaceuticals GmbH, Hannover
• 1998 – 2000 Wissenschaftlicher Mitarbeiter am Niedersächsischen Institut für Peptidforschung, Hannover
• 1995 - 1998 Wissenschaftlicher Mitarbeiter am Dr. Senckenbergischen Institut für Anatomie 2 (Experimentelle Neurobiologie), Frankfurt
• 05/1995-10/1995 Visiting Scientist am Institute for Anatomy and Cell Biology der Universität Bergen, Norwegen
• 1993- 1995 Wissenschaftlicher Mitarbeiter am Institut für Hormon- und Fortpflanzungsforschung, Hamburg
• 1993 Promotion in der Bio-Organischen Chemie der Universität Bremen, Titel: “Wachstum und Differenzierung von C6-Gliomazellen”, Bremen

Zusätzliche Qualifikationen

• 2025 Fachanatom

Preise und Auszeichnungen

• 2013 Lehrpreis des Medizinfachbereichs der Goethe Universität
   

Wissenschaftliche Schwerpunkte

1. Untersuchung der zellulären Signaltransduktion in vivo und in vitro.
2. Neuronale Plastizität und Gesundheit.
    

Online-Profile und Social Media Präsenz

ORCID:  0000-0002-5574-6323

Ausgewählte Publikationen:

1: Maronde E, Rami A. PDE Inhibitors and Autophagy Regulators Modulate CRE-Dependent Luciferase Activity in Neuronal Cells from the Mouse Suprachiasmatic Nucleus. Molecules. 2025 Aug 1;30(15):3229. doi:10.3390/molecules30153229. PMID: 40807406; PMCID: PMC12348409.

2: Bahlmann O, Taheri S, Spaeth M, Schröder K, Schilling AF, Dullin C, Maronde E. Skeletal Phenotyping of Period-1-Deficient Melatonin-Proficient Mice. J Pineal Res. 2024 Nov;76(8):e70020. doi: 10.1111/jpi.70020. PMID: 39697088; PMCID: PMC11656283.

3: Langiu M, Dehghani F, Hohmann U, Bechstein P, Rawashdeh O, Rami A, Maronde E. Adrenergic Agonists Activate Transcriptional Activity in Immortalized Neuronal Cells From the Mouse Suprachiasmatic Nucleus. J Pineal Res. 2024

Aug;76(5):e12999. doi: 10.1111/jpi.12999. PMID: 39092782.

4: Langiu M, Bechstein P, Neumann S, Spohn G, Maronde E. Regulation of CRE-Dependent Transcriptional Activity in a Mouse Suprachiasmatic Nucleus Cell Line. Int J Mol Sci. 2022 Oct 13;23(20):12226. doi: 10.3390/ijms232012226. PMID:36293078; PMCID: PMC9602552.

5:Dumas G, Goubran-Botros H, Matondo M, Pagan C, Boulègue C, Chaze T, Chamot-Rooke J, Maronde E, Bourgeron T. Mass-spectrometry analysis of the human pineal proteome during night and day and in autism. J Pineal Res. 2021, Apr;70(3):e12713. doi: 10.1111/jpi.12713. Epub 2021 Jan 11. PMID: 33368564; PMCID: PMC8047921.

6: Maronde E. Influence of Phosphodiesterase Inhibition on CRE- and EGR1-Dependent Transcription in a Mouse Hippocampal Cell Line. Int J Mol Sci. 2020 Nov 17;21(22):8658. doi: 10.3390/ijms21228658. PMID: 33212816; PMCID: PMC7696530.

7: Bahlmann O, Schürmann C, Maronde E. Altered laryngeal morphology in Period1 deficient mice. Ann Anat. 2019 May;223:43-48. doi: 10.1016/j.aanat.2019.01.009. Epub 2019 Feb 1. PMID: 30716467.

8: Stenzinger M, Karpova D, Unterrainer C, Harenkamp S, Wiercinska E, Hoerster K, Pfeffer M, Maronde E, Bönig H. Hematopoietic-Extrinsic Cues Dictate Circadian Redistribution of Mature and Immature Hematopoietic Cells in Blood and Spleen. Cells. 2019 Sep 5;8(9):1033. doi: 10.3390/cells8091033. PMID: 31491915; PMCID:PMC6769956.

9: Maronde E. Trehalose Activates CRE-Dependent Transcriptional Signaling in HT22 Mouse Hippocampal Neuronal Cells: A Central Role for PKA Without cAMP Elevation. Front Mol Neurosci. 2018 Oct 22;11:386. doi:10.3389/fnmol.2018.00386. PMID: 30405349; PMCID: PMC6204353.

10: Benabou M, Rolland T, Leblond CS, Millot GA, Huguet G, Delorme R, Leboyer M, Pagan C, Callebert J, Maronde E, Bourgeron T. Heritability of the melatonin synthesis variability in autism spectrum disorders. Sci Rep. 2017 Dec 18;7(1):17746. doi: 10.1038/s41598-017-18016-3. PMID: 29255243; PMCID: PMC5735101.

11: Bechstein P, Rehbach NJ, Yuhasingham G, Schürmann C, Göpfert M, Kössl M, Maronde E. The clock gene Period1 regulates innate routine behaviour in mice. Proc Biol Sci. 2014 Mar 5;281(1781):20140034.doi:10.1098/rspb. 2014.0034. Erratum in: Proc Biol Sci. 2014 Nov 22;281(1795). doi:10.1098/rspb.2014.0784. PMID: 24598427; PMCID: PMC3953852.

12: Schob S, Schicht M, Sel S, Stiller D, Kekulé AS, Paulsen F, Maronde E, Bräuer L. The detection of surfactant proteins A, B, C and D in the human brain and their regulation in cerebral infarction, autoimmune conditions and infections of the CNS. PLoS One. 2013 Sep 30;8(9):e74412. doi:10.1371/journal.pone.0074412.

13: Rawashdeh O, Maronde E. The hormonal Zeitgeber melatonin: role as a circadian modulator in memory processing. Front Mol Neurosci. 2012 Mar 6;5:27. doi: 10.3389/fnmol.2012.00027. PMID: 22408602; PMCID: PMC3295223.

14: Maronde E, Saade A, Ackermann K, Goubran-Botros H, Pagan C, Bux R, Bourgeron T, Dehghani F, Stehle JH. Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal gland. J Pineal Res. 2011 Aug;51(1):145-55. doi: 10.1111/j.1600-079X.2011.00880.x. Epub 2011 Apr 26. PMID: 21517958.

15: Benz AH, Shajari M, Peruzki N, Dehghani F, Maronde E. Early growth response-1 induction by fibroblast growth factor-1 via increase of mitogen-activated protein kinase and inhibition of protein kinase B in hippocampal neurons. Br J Pharmacol. 2010 Aug;160(7):1621-30. doi: 10.1111/j.1476-5381.2010.00812.x. PMID: 20649566; PMCID: PMC2936835.

16: Maronde E, Schilling AF, Seitz S, Schinke T, Schmutz I, van der Horst G, Amling M, Albrecht U. The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation. PLoS One. 2010 Jul 12;5(7):e11527. doi: 10.1371/journal.pone.0011527. PMID: 20634945; PMCID: PMC2902506.

17: Kramer FJ, Meyer M, Morgan D, Forssmann WG, Ständker L, Schliephake H, Mark S, Maronde E. Tissue inhibitor of metalloproteinases II (TIMP-2) is an osteoanabolic factor in vitro and in vivo. Eur J Med Res. 2008 Jun 24;13(6):292-8. PMID: 18558556.

18: Stephan S, van de Flierdt J, Loumi S, Bonaterra G, Kramer FJ, Fehr M, Tillmann HC, Forssmann WG, Maronde E. Intermittent administration of the circulating form of human parathyroid hormone (hPTH-1-37) prevents bone loss in ovariectomized rats. Eur J Med Res. 2007 Jan 31;12(1):13-20. PMID: 17363353.

19: Motzkus D, Loumi S, Cadenas C, Vinson C, Forssmann WG, Maronde E. Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways. Chronobiol Int. 2007;24(5):783-92. doi:10.1080/07420520701672481. PMID: 17994337.

20: Maronde E, Stehle JH. The mammalian pineal gland: known facts, unknown facets. Trends Endocrinol Metab. 2007 May-Jun;18(4):142-9. doi:10.1016/j.tem.2007.03.001. Epub 2007 Mar 19. PMID: 17374488.

21: Motzkus D, Schulz-Maronde S, Heitland A, Schulz A, Forssmann WG, Jübner M, Maronde E. The novel beta-defensin DEFB123 prevents lipopolysaccharide-mediated effects in vitro and in vivo. FASEB J. 2006 Aug;20(10):1701-2. doi:10.1096/fj.05-4970fje. Epub 2006 Jun 21. PMID: 16790530.

22: Fricke K, Schulz A, John H, Forssmann WG, Maronde E. Isolation and characterization of a novel proopiomelanocortin-derived peptide from hemofiltrate of chronic renal failure patients. Endocrinology. 2005 Apr;146(4):2060-8. doi: 10.1210/en.2004-1097. Epub 2005 Jan 13. PMID: 15650078.

23: Fricke K, Heitland A, Maronde E. Cooperative activation of lipolysis by protein kinase A and protein kinase C pathways in 3T3-L1 adipocytes. Endocrinology. 2004 Nov;145(11):4940-7. doi: 10.1210/en.2004-0803. Epub 2004 Jul29. PMID: 15284193.

24: Krause A, Sillard R, Kleemeier B, Klüver E, Maronde E, Conejo-García JR, Forssmann WG, Schulz-Knappe P, Nehls MC, Wattler F, Wattler S, Adermann K. Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. Protein Sci. 2003 Jan;12(1):143-52. doi:10.1110/ps.0213603. PMID: 12493837; PMCID: PMC2312392.

25: Maronde E, Motzkus D. Oscillation of human period 1 (hPER1) reporter gene activity in human neuroblastoma cells in vivo. Chronobiol Int. 2003 Jul;20(4):671-81. doi: 10.1081/cbi-120022413. PMID: 12916719.

26: Motzkus D, Albrecht U, Maronde E. The human PER1 gene is inducible by interleukin-6. J Mol Neurosci. 2002 Feb-Apr;18(1-2):105-9. doi: 10.1385/JMN:18:1-2:105. PMID: 11931340.

27: Krause A, Liepke C, Meyer M, Adermann K, Forssmann WG, Maronde E. Human natriuretic peptides exhibit antimicrobial activity. Eur J Med Res. 2001 May 29;6(5):215-8. PMID: 11410403.

28: Motzkus D, Maronde E, Grunenberg U, Lee CC, Forssmann W, Albrecht U. The human PER1 gene is transcriptionally regulated by multiple signaling pathways. FEBS Lett. 2000 Dec 15;486(3):315-9. doi: 10.1016/s0014-5793(00)02315-2. PMID:11119726.

29: Pfeffer M, Maronde E, Molina CA, Korf HW, Stehle JH. Inducible cyclic AMP early repressor protein in rat pinealocytes: a highly sensitive natural reporter for regulated gene transcription. Mol Pharmacol. 1999 Aug;56(2):279-89. doi:10.1124/mol.56.2.279. PMID: 10419546.

30: Maronde E, Pfeffer M, Olcese J, Molina CA, Schlotter F, Dehghani F, Korf HW, Stehle JH. Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis. J Neurosci. 1999 May1;19(9):3326-36. doi: 10.1523/JNEUROSCI.19-09-03326.1999. PMID: 10212292; PMCID: PMC6782257.

31: Maronde E, Middendorff R, Telgmann R, Müller D, Hemmings B, Taskén K, Olcese J. Melatonin synthesis in the bovine pineal gland is regulated by type II cyclic AMP-dependent protein kinase. J Neurochem. 1997 Feb;68(2):770-7. doi:10.1046/j.1471-4159.1997.68020770.x. PMID: 9003068.

32: Telgmann R, Maronde E, Taskén K, Gellersen B. Activated protein kinase A is required for differentiation-dependent transcription of the decidual prolactin gene in human endometrial stromal cells. Endocrinology. 1997 Mar;138(3):929-37.doi: 10.1210/endo.138.3.5004. PMID: 9048592.

33: Letz B, Schomerus C, Maronde E, Korf HW, Korbmacher C. Stimulation of a nicotinic ACh receptor causes depolarization and activation of L-type Ca2+channels in rat pinealocytes. J Physiol. 1997 Mar 1;499 ( Pt 2)(Pt 2):329-40.doi: 10.1113/jphysiol.1997.sp021930. PMID: 9080363; PMCID: PMC1159308.

34: Gjertsen BT, Mellgren G, Otten A, Maronde E, Genieser HG, Jastorff B, Vintermyr OK, McKnight GS, Døskeland SO. Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action. J Biol Chem. 1995 Sep 1;270(35):20599-607. doi:10.1074/jbc.270.35.20599. PMID: 7657638.

35: Maronde E, Middendorff R, Mayer B, Olcese J. The effect of NO-donors in bovine and rat pineal cells: stimulation of cGMP and cGMP-independent inhibition of melatonin synthesis. J Neuroendocrinol. 1995 Mar;7(3):207-14. doi: 10.1111/j.1365-2826.1995.tb00749.x. PMID: 7606247.

36: Musgrave IF, Genieser HG, Maronde E, Seifert R. Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. FEBS Lett. 1993 Mar 8;318(3):227-30. doi: 10.1016/0014-5793(93)80517-x. PMID: 8382631.

37: Yokozaki H, Tortora G, Pepe S, Maronde E, Genieser HG, Jastorff B, Cho-Chung YS. Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res. 1992 May 1;52(9):2504-8. PMID: 1314695.