Studies and academic training

• 2006 Adjunct Professor, Hannover Medical School
• 2001 Habilitation and Venia Legendi for Biochemistry; Hannover Medical School
• 1993 Doctorate (rer.nat.), University of Bremen
• 1989 Diploma in Biology
• 1985 - 1989 Study-2 Biology, University of Bremen (Vordiplom)
• 1983 - 1985 Study-1 Chemistry, University of Bremen (Vordiplom)

Scientific career

• 2025 -
• 2006 - 2025 Research group leader at the Dr. Senckenberg Institute of Anatomy 3 (Cellular and Molecular Anatomy) and 2 (Experimental Neurobiology), Goethe University, Frankfurt
• 05/2005-12/2005 Deputy Head of the Research Group for Clinical and Experimental Peptide Research, Hannover Medical School
• 2000 - 2005 Head of Department IPF Pharmaceuticals GmbH, Hanover
• 1998 - 2000 Research associate at the Lower Saxony Institute for Peptide Research, Hanover
• 1995 - 1998 Research associate at the Dr. Senckenberg Institute of Anatomy 2 (Experimental Neurobiology), Frankfurt
• 05/1995-10/1995 Visiting Scientist at the Institute for Anatomy and Cell Biology, University of Bergen, Norway
• 1993- 1995 Research associate at the Institute for Hormone and Reproduction Research, Hamburg, Germany
• 1993 PhD in Bio-Organic Chemistry at the University of Bremen, title: "Growth and differentiation of C6 glioma cells", Bremen

Additional qualifications

• 2025 Specialist anatomist

Prizes and awards

• 2013 Teaching award of the medical faculty of the Goethe University
  

Scientific focus

1. Investigation of cellular signal transduction in vivo and in vitro.
2. Neuronal plasticity and health.
   

Online profiles and social media presence

ORCID: 0000-0002-5574-6323

Selected publications:

1: Maronde E, Rami A. PDE Inhibitors and Autophagy Regulators Modulate CRE-Dependent Luciferase Activity in Neuronal Cells from the Mouse Suprachiasmatic Nucleus. Molecules. 2025 Aug 1;30(15):3229. doi:10.3390/molecules30153229. PMID: 40807406; PMCID: PMC12348409.

2: Bahlmann O, Taheri S, Spaeth M, Schröder K, Schilling AF, Dullin C, Maronde E. Skeletal Phenotyping of Period-1-Deficient Melatonin-Proficient Mice. J Pineal Res. 2024 Nov;76(8):e70020. doi: 10.1111/jpi.70020. PMID: 39697088; PMCID: PMC11656283.

3: Langiu M, Dehghani F, Hohmann U, Bechstein P, Rawashdeh O, Rami A, Maronde E. Adrenergic Agonists Activate Transcriptional Activity in Immortalized Neuronal Cells From the Mouse Suprachiasmatic Nucleus. J Pineal Res. 2024

Aug;76(5):e12999. doi: 10.1111/jpi.12999. PMID: 39092782.

4: Langiu M, Bechstein P, Neumann S, Spohn G, Maronde E. Regulation of CRE-Dependent Transcriptional Activity in a Mouse Suprachiasmatic Nucleus Cell Line. Int J Mol Sci. 2022 Oct 13;23(20):12226. doi: 10.3390/ijms232012226. PMID:36293078; PMCID: PMC9602552.

5:Dumas G, Goubran-Botros H, Matondo M, Pagan C, Boulègue C, Chaze T, Chamot-Rooke J, Maronde E, Bourgeron T. Mass-spectrometry analysis of the human pineal proteome during night and day and in autism. J Pineal Res. 2021, Apr;70(3):e12713. doi: 10.1111/jpi.12713. Epub 2021 Jan 11. PMID: 33368564; PMCID: PMC8047921.

6: Maronde E. Influence of Phosphodiesterase Inhibition on CRE- and EGR1-Dependent Transcription in a Mouse Hippocampal Cell Line. Int J Mol Sci. 2020 Nov 17;21(22):8658. doi: 10.3390/ijms21228658. PMID: 33212816; PMCID: PMC7696530.

7: Bahlmann O, Schürmann C, Maronde E. Altered laryngeal morphology in Period1 deficient mice. Ann Anat. 2019 May;223:43-48. doi: 10.1016/j.aanat.2019.01.009. Epub 2019 Feb 1. PMID: 30716467.

8: Stenzinger M, Karpova D, Unterrainer C, Harenkamp S, Wiercinska E, Hoerster K, Pfeffer M, Maronde E, Bönig H. Hematopoietic-Extrinsic Cues Dictate Circadian Redistribution of Mature and Immature Hematopoietic Cells in Blood and Spleen. Cells. 2019 Sep 5;8(9):1033. doi: 10.3390/cells8091033. PMID: 31491915; PMCID:PMC6769956.

9: Maronde E. Trehalose Activates CRE-Dependent Transcriptional Signaling in HT22 Mouse Hippocampal Neuronal Cells: A Central Role for PKA Without cAMP Elevation. Front Mol Neurosci. 2018 Oct 22;11:386. doi:10.3389/fnmol.2018.00386. PMID: 30405349; PMCID: PMC6204353.

10: Benabou M, Rolland T, Leblond CS, Millot GA, Huguet G, Delorme R, Leboyer M, Pagan C, Callebert J, Maronde E, Bourgeron T. Heritability of the melatonin synthesis variability in autism spectrum disorders. Sci Rep. 2017 Dec 18;7(1):17746. doi: 10.1038/s41598-017-18016-3. PMID: 29255243; PMCID: PMC5735101.

11: Bechstein P, Rehbach NJ, Yuhasingham G, Schürmann C, Göpfert M, Kössl M, Maronde E. The clock gene Period1 regulates innate routine behavior in mice. Proc Biol Sci. 2014 Mar 5;281(1781):20140034.doi:10.1098/rspb. 2014.0034. Erratum in: Proc Biol Sci. 2014 Nov 22;281(1795). doi:10.1098/rspb.2014.0784. PMID: 24598427; PMCID: PMC3953852.

12: Schob S, Schicht M, Sel S, Stiller D, Kekulé AS, Paulsen F, Maronde E, Bräuer L. The detection of surfactant proteins A, B, C and D in the human brain and their regulation in cerebral infarction, autoimmune conditions and infections of the CNS. PLoS One. 2013 Sep 30;8(9):e74412. doi:10.1371/journal.pone.0074412.

13: Rawashdeh O, Maronde E. The hormonal zeitgeber melatonin: role as a circadian modulator in memory processing. Front Mol Neurosci. 2012 Mar 6;5:27. doi: 10.3389/fnmol.2012.00027. PMID: 22408602; PMCID: PMC3295223.

14: Maronde E, Saade A, Ackermann K, Goubran-Botros H, Pagan C, Bux R, Bourgeron T, Dehghani F, Stehle JH. Dynamics in enzymatic protein complexes offer a novel principle for the regulation of melatonin synthesis in the human pineal gland. J Pineal Res. 2011 Aug;51(1):145-55. doi: 10.1111/j.1600-079X.2011.00880.x. Epub 2011 Apr 26. PMID: 21517958.

15: Benz AH, Shajari M, Peruzki N, Dehghani F, Maronde E. Early growth response-1 induction by fibroblast growth factor-1 via increase of mitogen-activated protein kinase and inhibition of protein kinase B in hippocampal neurons. Br J Pharmacol. 2010 Aug;160(7):1621-30. doi: 10.1111/j.1476-5381.2010.00812.x. PMID: 20649566; PMCID: PMC2936835.

16: Maronde E, Schilling AF, Seitz S, Schinke T, Schmutz I, van der Horst G, Amling M, Albrecht U. The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation. PLoS One. 2010 Jul 12;5(7):e11527. doi: 10.1371/journal.pone.0011527. PMID: 20634945; PMCID: PMC2902506.

17: Kramer FJ, Meyer M, Morgan D, Forssmann WG, Ständker L, Schliephake H, Mark S, Maronde E. Tissue inhibitor of metalloproteinases II (TIMP-2) is an osteoanabolic factor in vitro and in vivo. Eur J Med Res. 2008 Jun 24;13(6):292-8. PMID: 18558556.

18: Stephan S, van de Flierdt J, Loumi S, Bonaterra G, Kramer FJ, Fehr M, Tillmann HC, Forssmann WG, Maronde E. Intermittent administration of the circulating form of human parathyroid hormone (hPTH-1-37) prevents bone loss in ovariectomized rats. Eur J Med Res. 2007 Jan 31;12(1):13-20. PMID: 17363353.

19: Motzkus D, Loumi S, Cadenas C, Vinson C, Forssmann WG, Maronde E. Activation of human period-1 by PKA or CLOCK/BMAL1 is conferred by separate signal transduction pathways. Chronobiol Int. 2007;24(5):783-92. doi:10.1080/07420520701672481. PMID: 17994337.

20: Maronde E, Stehle JH. The mammalian pineal gland: known facts, unknown facets. Trends Endocrinol Metab. 2007 May-Jun;18(4):142-9. doi:10.1016/j.tem.2007.03.001. Epub 2007 Mar 19. PMID: 17374488.

21: Motzkus D, Schulz-Maronde S, Heitland A, Schulz A, Forssmann WG, Jübner M, Maronde E. The novel beta-defensin DEFB123 prevents lipopolysaccharide-mediated effects in vitro and in vivo. FASEB J. 2006 Aug;20(10):1701-2. doi:10.1096/fj.05-4970fje. Epub 2006 Jun 21. PMID: 16790530.

22: Fricke K, Schulz A, John H, Forssmann WG, Maronde E. Isolation and characterization of a novel proopiomelanocortin-derived peptide from hemofiltrate of chronic renal failure patients. Endocrinology. 2005 Apr;146(4):2060-8. doi: 10.1210/en.2004-1097. Epub 2005 Jan 13. PMID: 15650078.

23: Fricke K, Heitland A, Maronde E. Cooperative activation of lipolysis by protein kinase A and protein kinase C pathways in 3T3-L1 adipocytes. Endocrinology. 2004 Nov;145(11):4940-7. doi: 10.1210/en.2004-0803. Epub 2004 Jul29. PMID: 15284193.

24: Krause A, Sillard R, Kleemeier B, Klüver E, Maronde E, Conejo-García JR, Forssmann WG, Schulz-Knappe P, Nehls MC, Wattler F, Wattler S, Adermann K. Isolation and biochemical characterization of LEAP-2, a novel blood peptide expressed in the liver. Protein Sci. 2003 Jan;12(1):143-52. doi:10.1110/ps.0213603. PMID: 12493837; PMCID: PMC2312392.

25: Maronde E, Motzkus D. Oscillation of human period 1 (hPER1) reporter gene activity in human neuroblastoma cells in vivo. Chronobiol Int. 2003 Jul;20(4):671-81. doi: 10.1081/cbi-120022413. PMID: 12916719.

26: Motzkus D, Albrecht U, Maronde E. The human PER1 gene is inducible by interleukin-6. J Mol Neurosci. 2002 Feb-Apr;18(1-2):105-9. doi: 10.1385/JMN:18:1-2:105. PMID: 11931340.

27: Krause A, Liepke C, Meyer M, Adermann K, Forssmann WG, Maronde E. Human natriuretic peptides exhibit antimicrobial activity. Eur J Med Res. 2001 May 29;6(5):215-8. PMID: 11410403.

28: Motzkus D, Maronde E, Grunenberg U, Lee CC, Forssmann W, Albrecht U. The human PER1 gene is transcriptionally regulated by multiple signaling pathways. FEBS Lett. 2000 Dec 15;486(3):315-9. doi: 10.1016/s0014-5793(00)02315-2. PMID:11119726.

29: Pfeffer M, Maronde E, Molina CA, Korf HW, Stehle JH. Inducible cyclic AMP early repressor protein in rat pinealocytes: a highly sensitive natural reporter for regulated gene transcription. Mol Pharmacol. 1999 Aug;56(2):279-89. doi:10.1124/mol.56.2.279. PMID: 10419546.

30: Maronde E, Pfeffer M, Olcese J, Molina CA, Schlotter F, Dehghani F, Korf HW, Stehle JH. Transcription factors in neuroendocrine regulation: rhythmic changes in pCREB and ICER levels frame melatonin synthesis. J Neurosci. 1999 May1;19(9):3326-36. doi: 10.1523/JNEUROSCI.19-09-03326.1999. PMID: 10212292; PMCID: PMC6782257.

31: Maronde E, Middendorff R, Telgmann R, Müller D, Hemmings B, Taskén K, Olcese J. Melatonin synthesis in the bovine pineal gland is regulated by type II cyclic AMP-dependent protein kinase. J Neurochem. 1997 Feb;68(2):770-7. doi:10.1046/j.1471-4159.1997.68020770.x. PMID: 9003068.

32: Telgmann R, Maronde E, Taskén K, Gellersen B. Activated protein kinase A is required for differentiation-dependent transcription of the decidual prolactin gene in human endometrial stromal cells. Endocrinology. 1997 Mar;138(3):929-37.doi: 10.1210/endo.138.3.5004. PMID: 9048592.

33: Letz B, Schomerus C, Maronde E, Korf HW, Korbmacher C. Stimulation of a nicotinic ACh receptor causes depolarization and activation of L-type Ca2+channels in rat pinealocytes. J Physiol. 1997 Mar 1;499 ( Pt 2)(Pt 2):329-40.doi: 10.1113/jphysiol.1997.sp021930. PMID: 9080363; PMCID: PMC1159308.

34: Gjertsen BT, Mellgren G, Otten A, Maronde E, Genieser HG, Jastorff B, Vintermyr OK, McKnight GS, Døskeland SO. Novel (Rp)-cAMPS analogs as tools for inhibition of cAMP-kinase in cell culture. Basal cAMP-kinase activity modulates interleukin-1 beta action. J Biol Chem. 1995 Sep 1;270(35):20599-607. doi:10.1074/jbc.270.35.20599. PMID: 7657638.

35: Maronde E, Middendorff R, Mayer B, Olcese J. The effect of NO-donors in bovine and rat pineal cells: stimulation of cGMP and cGMP-independent inhibition of melatonin synthesis. J Neuroendocrinol. 1995 Mar;7(3):207-14. doi: 10.1111/j.1365-2826.1995.tb00749.x. PMID: 7606247.

36: Musgrave IF, Genieser HG, Maronde E, Seifert R. Preparations of Rp-cyclic adenosine 3',5'-phosphorothioate (Rp-cAMPS) can contain biologically active amounts of adenosine. FEBS Lett. 1993 Mar 8;318(3):227-30. doi: 10.1016/0014-5793(93)80517-x. PMID: 8382631.

37: Yokozaki H, Tortora G, Pepe S, Maronde E, Genieser HG, Jastorff B, Cho-Chung YS. Unhydrolyzable analogues of adenosine 3':5'-monophosphate demonstrating growth inhibition and differentiation in human cancer cells. Cancer Res. 1992 May 1;52(9):2504-8. PMID: 1314695.