systems is highly relevant for the development of new drugs and biotechnology. We studied allostery in a number of vital cellular processes such as translation, nitric oxide cellular signaling, cellular motility [...] The PBP allosteric site can be used to develop specific allosteric inhibitors of myosin isoforms with a wide range of potential therapeutic applications in the treatment of diseases, including cancer, heart [...] pathogenic UGP were identified. For the octameric human UGP, we demonstrated that oligomerization plays a number of important functional roles that help hUGP to fulfill its function as an exclusive switch in

endocytosis The pro-inflammatory cytokine IL-1 is a critical regulator of the innate immune response and the interleukin-1 (IL-1)-mediated signal transduction is a paradigm of immune signalling. IL-1 binding [...] binding, but the function of the IL-1RI internalization remained elusive. Recently, we demonstrated a critical role for the internalization of IL-1RI in the IL-1-mediated signal transduction. We also showed

tolerance by hyperinsulinemia and β-cell hyperplasia. However, during the course of T2DM a progressive β-cell dysfunction and a decline of the functional β-cell mass occurs. Consequently, β-cells cannot cope with [...] OE4340 Carl-Neuberg-Str. 1 30625 Hannover/Germany Research Program Type 2 diabetes mellitus (T2DM) is a heterogeneous and chronically progressive metabolic disease of epidemic proportions with increasing [...] can increase massively during hyperglycemia due to compensatorily increased insulin biosynthesis and a concomitant increased protein folding rate. Elevated hydrogen peroxide concentrations are associated

ndheit der BZgA Publikationen Safieddine, B., Geyer, S., Sperlich, S . et al. Factors associated with health-related quality of life in women with paid work at breast cancer diagnosis: a German repeated [...] Gender differences in psychosomatic complaints across occupations and time from 2006 to 2018 in Germany: a repeated cross-sectional study. BMC Public Health 25, 409. https://doi.org/10.1186/s12889-025-21462-8 [...] psychosomatic complaints at work vary by occupational groups of white- and blue-collar and level of skill: A cross sectional study. PLoS ONE. 2024;19(7):e0303811. https://doi.org/10.1371/journal.pone.0303811 Beller

Verantwortliche Person (SP, §14 & VP, §20c AMG) Stufenplanbeauftragter (SPB, nach §63a AMG) Informationsbeauftragter (IB, nach §74a AMG) Curriculum vitae

community and disseminate latest findings, TECHNOBEAT is happy to host a workshop at this year's GSCN Conference. The session will start off with a special keynote by Prof. Michael Laflamme, from Toronto General [...] University Medical Center, Utrecht, Netherlands Increased Retention of Cardiac Cell Aggregates in a Porcine Model of Myocardial Infarction Giacomelli, E., Leiden University Medical Center, Netherlands [...] Stem Cell-Derived Cardiac Fibroblasts Enhance Structural and Functional Cardiomyocyte Maturation in a Three-Dimensional Microtissue Environment Halliwell, J., University of Sheffield, United Kingdom The

03/2024 Allgemein-, Viszeral und Transplantationschirurgie, Direktor: Prof. Dr. med. A. Königsrainer / Prof. Dr. med. A. L. Mihaljevic Ärztlicher Mitarbeiter, Universitätsklinikum Tübingen 10/2016 - 03/2024 [...] 03/2024 Allgemein-, Viszeral und Transplantationschirurgie, Direktor: Prof. Dr. med. A. Königsrainer Postdoctoral research fellowship, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 07/2013

neuropeptides. Other studies have reported that neurons in turn are influenced and primed by cytokines, a phenomenon well known through increased pain in locally inflamed tissue. How this bidirectional com [...] communication changes during aging is yet not been addressed. Chronic pain and itch conditions are a main source of decreased quality of life in the elderly population. Peripheral neuropathies effecting [...] proprioception are causing gait instability and increase the risk to fall and with this start a vicious cycle of morbidity and mortality. This project will be the first attempt to characterize and define

students and postdocs. Hannover Medical School is the only “medical faculty” in Germany which hosts such a large number of structured doctoral programs under the roof of one graduate school: Six (MD)/PhD programs [...] programs and three StrucMed programs, unique programs for undergraduate medical students to perform a Dr.med. thesis. Our Institute is currently part of the following teaching / education activities at [...] Medicine - PhD program Regenerative Sciences StrucMed-Program [ https://www.mhh.de/hbrs/strucmed ]. A structured 9-month program for MD students. Clinical lectures, Department of Cardiology and Angiology

Berufliche Tätigkeit: 2011-2013 Praktische Tätigkeit als Psychologische Psychotherapeutin in Ausbildung (PPiA) in der psychiatrischen Tagesklinik, auf der Station für schizophrene Spektrumserkrankungen sowie auf [...] 2013-2017 Praktische Tätigkeit als Psychologische Psychotherapeutin in fortgeschrittener Ausbildung (PPiA) in der Abteilung für Neuropsychologie der Klinik für Psychiatrie und Psychotherapie der Helios Dr. [...] z für Psychotherapie der Johannes Gutenberg-Universität Mainz (Leitung: Prof. Dr. M. Witthöft, Dr. A. Benecke) 2018 Praktische Tätigkeit als Psychologische Psychotherapeutin auf der Station für affektive