of the molecular mechanisms of proteins whose function is vital for the health of the human organism. Combining leading techniques for structure determination with state-of-the-art cell biological and [...] analyse the structural determinants for the proper function of the protein of interest. Our core expertise for structure determination is X-ray crystallography. For the analysis of large protein complexes [...] Disease Relevant Proteins Copyright: Nico Herzog Fotografie PD Dr. rer. nat. Susanne Eschenburg Institute for Biophysical Chemistry, OE4350 Hannover Medical School Carl-Neuberg-Straße 1 30625 Hannover Office:
Keck J, Stripecke R. “In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution” Biomedicines . 2021 Aug 5;9(8):961. doi: 10. [...] Lachmann N , Cornu TI, Mussolino C, Schäfer R, Cathomen T. “CRISPR-Cas12a for Highly Efficient and Marker-Free Targeted Integration in Human Pluripotent Stem Cells” Int J Mol Sci. 2024 Jan 12;25(2):985. doi: [...] Lachmann N , Verboom M, Frieling H, Hallensleben M, Martin U. An Improved Protocol for Targeted Differentiation of Primed Human Induced Pluripotent Stem Cells into HLA-G-Expressing Trophoblasts to Enable the
compartment as resilient markers for safe kidney transplantation Nick Heise, GERMANY, Heise.Nick @ mh-hannover.de Supervisor: Prof. Dr. Christian Bär / Dr. Jeannine Höpfner (Institute of Molecular and Translational [...] tissue-specific AAV vectors for neuromuscular gene therapies Subham Rana , INDIA, Subham.Rana @ mh-hannover.de Supervisor: Prof. Dr. Christian Bär / Prof. Dr. Thomas Thum (Institute of Molecular and Translational [...] Wilson.Agyapong @ mh-hannover.de Supervisor: Dr. Natalie Weber, PhD / Prof. Dr. Dr. Thomas Thum (Institute of Molecular and Translational Therapeutic Strategies IMTTS and Fraunhofer ITEM) Project: Investigation
from Stem Cells for Therapy and Drug Safety Evaluation 14.01.2021 Dr. Jessica Rademacher MHH, Klinik für Pneumologie Antibiotic Stewardship 09.07.2020 Dr. Meik Kunz, Erlangen Institut für Medizininformatik [...] Erlangen-Nürnberg Integrative bioinformatics analysis and modeling of human physiology 18.06.2020 Prof. Christian Wahl-Schott, MHH (Institut für Neurophysiologie) Second messenger-activated cation channels: [...] Filippo Perbellini, MHH/Imperial College London Living myocardial slices: a novel multicellular model for cardiac translational research 28.11.2019 Dr. Monika Bokori-Brown, Exeter Unlocking the molecular secrets
Witzke O, Hoyer PF, Schmid KW, Kribben A, Bergmann C, Nürnberger J: The mTOR pathway is activated in human autosomal-recessive polycystic kidney disease. Kidney Blood Press Res 2010; 33(2): 129-38 Bertram [...] M, Bisdas S, Haverich A, Teebken OE: Eight-year experience with cryopreserved arterial homografts for the in situ reconstruction of abdominal aortic infections. J Vasc Surg 2010; 52(2): 323-30 Brandt D [...] Volkmann X, Anstätt M, Länger F , Manns MP, Schulze-Osthoff K, Bantel H: Serum biomarkers of cell death for monitoring therapy response of gastrointestinal carcinomas. Eur J Cancer 2010; 46(8): 1464-1473 Bruns
Klasse II Myosinen . Dr. Mamta-Amruta-Nayak , Institut für Molekular- und Zellphysiologie. Kinetische Untersuchungen der Aktivität von Myofibrillen aus humanen Biopsien von Kardiomyopathie-Patienten . Prof [...] Bogdan Iorga , Institut für Molekular- und Zellphysiologie. Validation of the anti-cancer activity of the myosin-9 inhibitor adhibin in the mouse tumor model . Prof. Dr. Detlef Neumann , Institut für Pharmakologie [...] Knölker , Institute für Organische Chemie. Cornell University New York, USA Function of 3’,5’-cAMP in regulating the actin cytoskeleton in Arabidopsis . Dr. Aleksandra Skirycz . Boyce Thompson Institute (BTI)
martin@mh-hannover.de Supervisor: Prof. Dr. Hildegard Büning, Institute of Experimental Haematology, OE 6960 Project:AAV vector based approaches for immunotherapy of cancer. Final exam November 2022. Janin [...] Janin Bublitz GERMANY Supervisor: Prof. Dr. Doris Steinemann, Institute of Human Genetics, OE 6300 Project: Nachweis und Bedeutung von strukturellen Genom-Varianten beim familiären Brustkrebs (Detection and [...] systemic and pulmonary human immune response after allergic, inflammatory and infectious provocation. Final exam November 2021 . Ci Chu CHINA Supervisor: Prof. Dr. Dietmar Manstein, Institute of Biophysical Chemistry
Structural biology of host-pathogen interactions Dr. Thomas Reubold Institute for Biophysical Chemistry, OE4350 Hannover Medical School Carl-Neuberg-Straße 1 30625 Hannover Office: Building I4, Floor S0 [...] and protein complexes from human pathogens. We seek to understand how these proteins contribute to the establishment of manifest disease as well as to identify drug targets for the development of novel [...] antimicrobial therapies. We use X-ray crystallography as primary technique for structure determination as well as a wide array of biochemical and biophysical methods to complement our structural studies
genetisch modifizierter humaner pluripotenter Stammzellen Durch Verwendung „maßgeschneiderter“ Designernukleasen ist eine deutlich effizientere zielgerichtete genetische Modifikation humaner iPS-Zellen möglich [...] haben Wissenschaftler des LEBAOs nun zusammen mit Wissenschaftlern der Institute für experimentelle Hämatologie und für Humangenetik der MHH, sowie mit weiteren Kooperationspartnern des Universitätsklinikums [...] Efficient designer nuclease-based homologous recombination enables direct PCR screening for footprintless targeted human pluripotent stem cells. Stem Cell Reports 2, no. 1:107
shygiene Institut für Virologie Institut für Immunologie Institut für Versuchstierkunde und Zentrales Tierlaboratorium Institut für Molekularbiologie Institut für Transfusionsmedizin Institut für Klinische [...] Philosophie der Medizin Zentrum Pathologie, Forensik und Genetik Zentrum Pathologie, Forensik und Genetik Institut für Pathologie Institut für Humangenetik Institut für Rechtsmedizin Zentrum Pharmakologie [...] Toxikologie Institut für Klinische Pharmakologie Institut für Molekulare und Translationale Therapiestrategien Institut für Pharmakologie Institut für Pharmako- und Toxikogenomikforschung Institut für Toxikologie