ng the urgent need for innovative therapies. To address this challenge, our research investigates fibrotic processes in the heart and lung using various model systems. We screen for potential therapeutic [...] therapeutic candidates involved in these processes by utilizing human cardiac cell types, living human myocardial and lung slices, patient-derived material, and diverse in vivo disease models. Our research was [...] kidneys. The study of cardiac and lung fibrosis, in particular, is a major research focus at our institute. Cardiac fibrosis is a key driver of heart failure, which is the leading cause of morbidity and

mit dem Institut für Biochemie und Zelluläre Biologie der Otto von Guericke Universität Magdeburg und der Urologischen Klinik des Klinikums Diepholz beim 27. Congress of the World Association for Sexual [...] tation “A re-evaluation of the expression and distribution of nitric oxide synthase (NOS) in the human vagina using the Tyramide Signal Amplification (TSA) technique” mit dem Congress Award in der Kategorie

Publikationen Publications of the Institute of Clinical Biochemistry since 2019 and the former Institute for Cellular Chemistry since 2003 sorted by year and first author. Publikationen 2025 Carneiro P [...] Ruppert T, Wittbrodt J, Bakker H , Buettner FFR (2021). The C-Mannosylome of Human Induced Pluripotent Stem Cells Implies a Role for ADAMTS16 C-Mannosylation in Eye Development. Mol Cell Proteomics. 2021;20:100092 [...] Glage S, Abeln M , Zweigerdt R, Munder A, Viemann D, Ackermann M, Lachmann N (2021). Human iPSC-derived macrophages for efficient Staphylococcus aureus clearance in a murine pulmonary infection model. Blood

Cantz T. A selectable all-in-one CRISPR prime editing piggyBac transposon allows for highly efficient gene editing in human cell lines. Sci Rep. 2021 Nov 12;11(1):22154. doi: 10.1038/s41598-021-01689-2. [...] Rolle spielen.“ Doris Steinemann Mitarbeiter/innen Doris Steinemann , Prof. Dr. rer. nat., Fachhumangenetikerin, Leitung Winfried Hofmann , Dr. rer. nat., wissenschaftlicher Mitarbeiter, Bioinformatik, [...] Schrappe M, Schlegelberger B, Stanulla M, Steinemann D . The Clinical Utility of Optical Genome Mapping for the Assessment of Genomic Aberrations in Acute Lymphoblastic Leukemia. Cancers (Basel). 2021 Aug 3

medicine, this situation calls for extensive research and new approaches to the prevention and therapy of infectious diseases. In order to address this need, the Center for Infection Biology (ZIB) was founded [...] the Helmholtz Centre for Infection Research (HZI) in Braunschweig, the University of Veterinary Medicine Hannover, Foundation, and the University of Hannover. In 2005 the "Centre for Experimental und Clinical [...] potential of the affiliated institutes and participating disciplines within the field of infection biology and to systematically exploit the resulting synergies to provide a platform for qualified research projects

of the Institute of Immunology since 2002. Rodrigo Gutierrez Jauregui, PhD Gutierrez.Rodrigo @ mh-hannover.de Tel: 9731 Rodrigo is focusing on characterization of the immune response of both humans and mice [...] projects of the lab. She has been a member of the institute since 2003. Anja Schimrock Schimrock.Anja @ mh-hannover.de Tel: 9727 Anja has been part of the institute since 2007. She is always happy to help everyone [...] the dynamics of infection and immune cells with and against HCMV in an infection model of explanted human lungs. Michaela Friedrichsen Friedrichsen.Michaela @ mh-hannover.de Tel: 9741 Michaela is an expert

3389/fimmu.2020.592328 In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution. Kumar S, Koenig J, Schneider A, Wermeling F, [...] Insertion Into Genomic Safe Harbors for Human Gene Therapy. Papapetrou EP, Schambach A. Mol Ther. 2016 Apr;24(4):678-84. doi: 10.1038/mt.2016.38. Review. Retroviral Vectors for Cancer Gene Therapy. Schambach [...] time for base editing in the mitochondria. Morgan MA, Lange L, Schambach A. Signal Transduct Target Ther 2022;7(1):213 DOI: 10.1038/s41392-022-01068-x Hepatocellular Carcinoma Is a Natural Target for Ad

Samir Sarikouch, Hannover Medical School, GER Yoji Sato, National Institute of Health Sciences, JP Gerald Schumann, Paul Ehrlich Institut, GER Henrik Semb, Helmholtz Center, GER Joost Sluijter, University [...] Medical School, GER Michael Harder, CorLife, GER Michal Izrael, Kadimastem, ISR Nils Hoppe, Centre for Ethics and Law in the Life Sciences, GER Serge Jooris, Ovizio, BEL Allan Karlsen, Novo Nordisk, DK

Lehrbeauftragte am Institut für Diversitätsforschung an der Universität Göttingen November 2020 – Juli 2025: Koordinatorin des Kompetenzzentrums für geschlechtersensible Medizin am Institut für Ethik, Geschichte [...] che Mitarbeiterin und Lehrbeauftragte am Institut für Diversitätsforschung an der Universität Göttingen April 2022 – Oktober 2022: Lehrbeauftragte am Institut für Diversitätsforschung an der Universität [...] /Gather/Hempeler (2024): Intersectionality as a tool for clinical ethics consultation in mental healthcare. In: Philosophy, Ethics, and Humanities in Medicine 19, 6. Doi: 10.1186/s13010-024-00156-w . (2024):

Healthcare for Culturally Diverse Populations: Insights from a Qualitative Study on Dementia Care with the Turkish Immigrant Community in Germany”. In: Social Diversity and Access to Healthcare for Minority [...] 12688/bioethopenres.17486.1 Katzer M, Salloch S, Schindler C, Mertz M (2023): Ethical requirements for human challenge studies: a systematic review of reasons. Clinical Pharmacology & Therapeutics 114:1209-1219 [...] doi:10.1177/26323524221083676. Kruse J, Mueller R, Aghdassi AA, Lerch MM, Salloch S (2022): Genetic Testing for Rare Diseases: A Systematic Review of Ethical Aspects. Frontiers in genetics vol. 12 701988