destruction of the insulin-secreting cells. ROS generation in this destruction process is caused by gene expression changes, inhibition of enzymes or changes of the cellular redox homeostasis. In this scenario
spezialisierte morphologische Diagnostik geht Hand in Hand mit Fortschritten bei der Identifizierung von Genen, die eine Hörstörung bedingen. Durch die sehr erfolgreiche Therapie kongenital tauber Kinder mit einem
herausragende Rolle. Aufgrund des erheblichen Polymorphismus der dem HLA-Komplex zugrunde liegenden Gene können derzeit an den transplantationsrelevanten HLA-Genorten A, B, C, DRB1, DQB1 und DPB1 mehr als
5;113(6):1391-2. Theophile K, Hussein K, Kreipe H, Bock O. Expression profiling of apoptosis-related genes in megakaryocytes: BNIP3 is downregulated in primary myelofibrosis. Exp Hematol. 2008 Dec;36(12):1728-38
manipulations to explore the molecular, cellular and physiological consequences of loss- and gain-of-gene functions. All in all, this work may aid in establishing a paradigm for the molecular complexity guiding
Atemfunktion, mit einer schweren Ateminsuffizienz einher. Bis heute sind Mutationen in drei verschiedenen Genen (ATP-binding cassette protein member A3, Surfactant Proteine B und C) als Ursache bekannt. Sowohl
Regenerative Medicine Further publications: Gene Therapy Vectorology / Biosafety Hematopoiesis 2022 Targeted biallelic integration of an inducible Caspase 9 suicide gene in iPSCs for safer therapies Wunderlich [...] Geis FK, Lange L, Müller FJ, Lenz D, Zychlinski D, Steinemann D, Morgan M, Moritz T, Schambach A. Gene Ther 2017;24(5):298-307 TALEN-mediated functional correction of human iPSC-derived macrophages in [...] Beh-Pajooh A, Fiedler J, Pfanne A, Schambach A, Thum T, Cantz T, Moritz T. Stem Cell Res 2017;20:70-75 Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem
2018; 50(3): e453 Anwar SL, Lehmann U : Detection of Aberrant DNA Methylation Patterns in the RB1 Gene. Methods Mol Biol. 2018; 1726: 35-47 Barrantes-Freer A, Engel AS, Rodríguez-Villagra OA, Winkler A [...] 556-558 Bartels S , Schipper E , Hasemeier B , Kreipe H , Lehmann U : Hotspot mutations in cancer genes may be missed in routine diagnostics due to neighbouring sequence variants. Exp Mol Pathol. 2018; [...] Persing S , Henkel D , Lehmann U , Kreipe H : Activating human epidermal growth factor receptor 2 (HER2) gene mutation in bone metastases from breast cancer. Virchows Arch. 2018; 473(5): 577-582 Cramer L, Brix
1038/s41416-022-01908-1. Epub 2022 Jul 23. PMID: 35871236 Free PMC article. [Genes and pathways: FGFR2 translocations and gene fusion analysis]. Neumann O, Ball M, Lehmann U, Schirmacher P, Stenzinger A [...] Epub 2022 Jul 4. PMID: 35925311 German. No abstract available. [Erratum to: Genes and pathways: FGFR2 translocations and gene fusion analysis]. Neumann O, Ball M, Lehmann U, Schirmacher P, Stenzinger A [...] Xanthouli P, Egenlauf B, Seeger R, Hoeper MM, Jonigk D, Grünig E, Eichstaedt CA. Genes (Basel). 2022 Apr 26;13(5):759. doi: 10.3390/genes13050759. PMID: 35627145 Free PMC article. AGO Recommendations for the Diagnosis
pathologic gene-expression after myocardial infarction in mice. J Mol Cell Cardiol. 2018. www.ncbi.nlm.nih.gov/pubmed/30118791 Bauersachs J, Heymans S. Scientific updates on the interaction of genes, epigenetics [...] Jara-Avaca M, Gruh I, Martin U, Wollert KC, Gohla A, Katus HA, Muller OJ, Bauersachs J, Heineke J. A gene therapeutic approach to inhibit CIB1 ameliorates maladaptive remodeling in pressure overload. Cardiovasc