during the poster session. New AAV vectors for cardiac-directed gene therapy July 2022 AAV vectors are promising delivery tools for human gene therapy. However, broad tissue tropism and pre-existing immunity [...] regulatory elements of hypoxia-sensitive genes in silico predicted the transcription factors SP1 and KLF5 as potential orchestrators in human endothelial hypoxic gene expression. Further studies revealed that [...] Gary Ruvkun, for their “groundbreaking discovery” of microRNA and its role in post-transcriptional gene regulation. It all began with a small worm, C. elegans, which despite its small size of around 1mm
Tsiavaliaris, G., Hensel, N., Viero, G., Ponimaskin, E., and Claus P. (2024). The Spinal Muscular Atrophy gene product regulates actin dynamics. FASEB J. , https://doi.org/10.1096/fj.202300183R Küçükdogru, R.* [...] Hedtfeld, S, Steinemann, D., Tümmler, B., Tsiavaliaris, G., Stanke, F. (2016). Biochim. Biophys. Acta – Gene Regulatory Mechanisms , 1859, 1411-1428. DOI: https://10.1016/j.bbagrm.2016.09.002 Poorly understood [...] Tsiavaliaris, G. (2015). BioMed Res. Int. , review. DOI: https://10.1155/2015/245154 A novel Dock8 gene mutation confers diabetogenic susceptibility in the LEW.1AR1/Ztm-iddm rat, an animal model of human
Brakensiek K, Buhr T, Schlué J, Wiese B, Kreipe H: The Suppressor of Cytokine Signalling -1 (SOCS-1) gene is overexpressed in Philadelphia chromosome negative chronic myeloproliferative disorders. Leuk Res [...] island mapping using PyrosequencingTM reveals disease-specific methylation patterns of the CDKN2B gene in Myelodysplastic Syndrome and Myeloid Leukemia. Clin Chem 2007; 53(1): 17-23 Büsche G, Ganser A [...] silver enhanced in-situ hybridisation (SISH) and fluorescence-ISH (FISH) for the validation of HER2 gene status in breast carcinoma according to the guidelines of the American Society of Clinical Oncology
sequenzierten die Forschenden das Transkriptom (also die Gesamtheit der in einer Zelle abgeschriebenen Gene) von mehr als 100000 individuellen Zellen von insgesamt 12 Patientinnen und Patienten (8 mit akuter
nach den charakteristischen Gendefekten suchen“, sagt PD Dr. Ringshausen. Bislang sind mehr als 50 Gene bekannt, die an der Entstehung von PCD beteiligt sein können. „Vermutlich sind es aber viel mehr“
2015. »Songen aru shi? Nihon ni okeru kanja no jizen shijisho no kojinteki kaishaku to shakaiteki gen-jitsu«. [Würdevolles Sterben? Individuelle Deutungen und gesellschaftliche Wirklichkeiten von Pati
können. Von großer Bedeutung ist schließlich, Mechanismen der burst-like Transkription der betroffenen Gene für sarkomerische Proteine in Kardiomyozyten aufzuklären, um die Expression modulieren zu können und
biopharma know-how meets bioreactor innovation in upstream bioprocessing Cell gene Therapy Insights & DASGIP, Philip Nold Cell Gene Therapy Insights Expert View: Large-scale stem cell expansion and differentiation [...] therapy with finasteride improves cardiac function, attenuates remodeling and reverts pathologic gene-expression after myocardial infarction in mice. Journal of Molecular and Cellular Cardiology 10.1016/j [...] February 2018, "Safety assessment of cell therapy products: current advance challenges" Cell and Gene Therapy Catapult, London UK Pluripotency tests, Peter Andrews, September 2018, "Round Table: Challenges
Kosanke, M., Montag, J., Thum, T., Zweigerdt, R., Kraft, T., Iorga, B. , and Meissner, J.D. (2023), J Gen Physiol (2023) 155 (11): e202313377, https://doi.org/10.1085/jgp.202313377 , Online ahead of print [...] B. Iorga , Phosphate has dual roles in cross-bridge kinetics in rabbit psoas single myofibrils, J. Gen. Physiol. 2021 Vol. 153 No. 3, DOI: 10.1085/jgp.202012755, PubMed Peter Franz, Vincent Gassl , Andrea [...] (Nedherland) Springer Rezensionen und Leitartikel Why make a strong muscle weaker? Iorga B., Kraft T ., J Gen Physiol, . 2021 Jul 5;153(7):e202112928.doi: 10.1085/jgp.202112928. Epub 2021 Jun 9. PubMed Stehle
komplett verschont. Aktuell werden zwei weitere HLA-Rezeptoren gebaut und getestet. „Es gibt mehrere Gene im HLA-System, die zudem in ganz vielen Varianten vorliegen“, stellt die Nachwuchsforscherin fest