T, von Einem J: Major tegument protein pp65 of human cytomegalovirus is required for the incorporation of pUL69 and pUL97 into the virus particle and for viral growth in macrophages. J Virol 2009; 83(6): [...] Schlegelberger B, Kreipe H, Lehmann U: Comprehensive genetic and functional characterization of IPH-926: a novel CDH1-null tumour cell line from human lobular breast cancer. J Pathol 2009; 217(5): 620-32 [...] D, Lück HJ, Kreipe H, Schlegelberger B: Histopathological criteria and selection algorithms for BRCA1 genetic testing. Cancer Genet Cytogenet 2009; 189(2): 105-11 Ganzenmueller T, Henke-Gendo C, Schlue

the human complement regulatory protein CD59. Xenotransplantation 2006; 13(4): 345-56 Doe JY, Funk M, Mengel M, Doehring E, Ehrich JH: Nephrotic syndrome in African children: lack of evidence for 'tropical [...] Winkler M, Haverich A, Wiebe K: Hyperacute rejection in ex vivo-perfused porcine lungs transgenic for human complement regulatory proteins. Transpl Int 2006; 19(3): 225-232 Rifai K, Flemming P, Manns MP, [...] surrogate marker for estrogen receptor-negative carcinomas. Lab Invest 2006; 86(3): 246-53 Traub F, Mengel M, Lück HJ, Kreipe HH, von Wasielewski R: Progostic impact of Skp2 and p27 in human breast cancer

of a functional promoter of the human plakoglobin gene. Eur J Endocrinol 2001; 145(5): 625-33 Roth-Eichhorn S, Heitmann B, Flemming P, Kubicka S, Trautwein C: Evidence for the decreased expression of the [...] Kispert A, von Wasielewski R, Brabant G: Identification of a Wnt/beta catenin signaling pathway in human thyroid cells. Endocrinology 2001; 142(12): 5261-6 Hogemann D, Flemming P, Kreipe H, Galanski M: [...] Flemming P, Yamamoto M, Shimahara Y, Yamaoka Y, Fukumoto M: Microsatellite instability and alternative genetic pathway in intrahepatic cholangiocarcinoma. J Hepathol 2001; 35(2): 235-44 Nave H, Mössinger E, Feist

Together with Philipp Altrock and Arne Traulsen from the Max Planck Institute for Evolutionary Biology, we have developed a unique model for lobular carcinoma in situ (LCIS) of the mammary gland. The model [...] immunohistochemical markers for the differential diagnosis between collagenous spherulosis and adenoid-cystic carcinoma of the mammary gland. Her study has been published in Human Pathology . https://www. [...] trial in the Journal of the National Cancer Institute . This collaboration with the AG clinical studies in breast cancer investigated different regimes for neoadjuvant chemotherapy. www.ncbi.nlm.nih.g

disease to test this treatment. The project is funded by the Institute for Biomedical Translation (IBT) Lower Saxony in the amount of 800,000 € for a period of two years. Read more about LuFex here: https://www [...] strategy for heart disease. Please find the original article here: https://www.sciencedirect.com/science/article/pii/S0022282824001615?via%3Dihub A reporter system for live cell tracking of human cardiomyocyte [...] on an innovative ex vivo system - living human myocardial slices. For the first time, a new drug against heart failure was successfully tested on this living human heart tissue, resulting in a partial regression

MHH-internal cooperations Institute for Human Genetics Institute for Clinical Biochemistry Institute of Virology Clinic for Ophthalmology Clinic for Anaesthesiology Clinic for ear, nose and throat medicine [...] information systems can be used for specific research questions. We have supplemented this system with large patient registries for special indications (for example, a registry for the special outpatient clinic [...] Epigenetic regulation of BDNFIV upon antidepressant treatment Establishment of Gene panel for therapy response for antidepressant treatment Effect of antidepressants on BDNF secretion by neurons and reuptake

so das bakterielle Verteidigungssystem außer Kraft setzt. Poxine – Nukleasen aus humanpathogenen Viren Auch humanpathogene Viren entwickelten Strategien, um die zelluläre Immunabwehr zu umgehen. Zum Beispiel [...] Krankheitsbezug der Forschung Die übergeordnete Forschungsrichtung des Instituts für Pharmakologie ist die molekulare und pathophysiologische Analyse von Signaltransduktionsvorgängen. Immunologische E [...] Mechanismen werden über die Aktivierung von PKA durch cAMP und von PKG durch cGMP vermittelt. Im Institut für Pharmakologie werden seit einigen Jahren verschiedene Untersuchungen zu cCMP und cUMP durchgeführt

Witzke O, Hoyer PF, Schmid KW, Kribben A, Bergmann C, Nürnberger J: The mTOR pathway is activated in human autosomal-recessive polycystic kidney disease. Kidney Blood Press Res 2010; 33(2): 129-38 Bertram [...] M, Bisdas S, Haverich A, Teebken OE: Eight-year experience with cryopreserved arterial homografts for the in situ reconstruction of abdominal aortic infections. J Vasc Surg 2010; 52(2): 323-30 Brandt D [...] Volkmann X, Anstätt M, Länger F , Manns MP, Schulze-Osthoff K, Bantel H: Serum biomarkers of cell death for monitoring therapy response of gastrointestinal carcinomas. Eur J Cancer 2010; 46(8): 1464-1473 Bruns

Requirements for Pharmaceuticals for Human Use (ICH) seit 01/2007 Deutscher Vertreter in der Scientific Advice Working Party (SAWP) des Committee for Medicinal Products for Human Use (CHMP) 04/2015 - 11/2017 [...] Europäischer Experte in der "Drafting Group for ICH-E17" des International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use (ICH) 10/2010 - 10/2018 Mitglied und (ab [...] Beirats des Instituts für Qualität und Wirtschaftlichkeit im Gesundheitswesen (IQWIG) 09/2009 – 09/2018 Mitglied der Biostatistics Working Party (BSWP) des Committee for Medicinal Products for Human Use (CHMP)

tissues for application in quantitative real-time PCR. Diagn Mol Pathol 2008; 17(2): 101-6 von Falck C, Rodt T, Rosenthal H, Länger F, Goesling T, Knapp WH, Galanski M: (68)Ga-DOTANOC PET/CT for the detection [...] HJ, Gunzer F: Sensitivity to Escherichia coli Nissle 1917 in mice is dependent on environment and genetic background. Int J Exp Pathol 2008; 89(1): 45-54 Bock O, Höftmann J, Theophile K, Hussein K, Wiese [...] KAI1/CD82 is a novel target of estrogen receptor-mediated gene repression and downregulated in primary human breast cancer. Int J Cancer 2008; 123(10): 2239-46 Ciesek S, Helfritz FA, Lehmann U, Becker T, Strassburg