der Landeshauptstadt und Region Hannover Professur für Notfallmedizin - Akkonhochschule für Humanwissenschaften - Berlin ✆ +49(0)511 532-3495/-3496 ℻ +49(0)511 532-8033 ✉ flemming.andreas @ mh-hannover.de

e Therapie Pharmakologie Klinische Pharmakologie Psychopharmakologie Grundlagenwissenschaften Humangenetik Zentrallabor Biochemie Glykoanalytik Biometrie Neuroanatomie Psyche Psychiatrie Psychosomatik

important drug targets was considered to be a remote idea more than twenty years ago. Meanwhile, the human kinome is known and the spectacular therapeutic results obtained with STI571 (Gleevec) , suggested

lle Hämatologie) Prof. Dr. Lars Dölken (Virologie) Prof. Dr. Nataliya Di Donato (Institut für Humangenetik) Prof. Dr. Anna-Maria Dittrich (Pädiatrische Pneumologie) Prof. Dr. Meike Stiesch (Klinik für

3389/fimmu.2020.592328 In Vivo Lentiviral Gene Delivery of HLA-DR and Vaccination of Humanized Mice for Improving the Human T and B Cell Immune Reconstitution. Kumar S, Koenig J, Schneider A, Wermeling F, [...] Hematopoiesis 2023 CXCL1 confers a survival advantage in Kaposi's sarcoma-associated herpesvirus-infected human endothelial cells through STAT3 phosphorylation Lee M, Lee J, Kang S, Wirth D, Yoo S, Park C, Lee [...] Deficiency Hildegard Büning, Andrew H. Baker, Uta Griesenbach, Terence R. Flotte, and Adrian J. Thrasher HUMAN GENE THERAPY, VOLUME 32, NUMBERS 1 and 2 DOI: 10.1089/hum.2021.29147.hbu Generation of macrophages

furthermore perform patch clamp analyses on human induced pluripotent stem cell derived cardiomyocytes (hiPSC-CMs) to support projects that investigate diverse human cardiac diseases (e.g. Brugada syndrome [...] on-exchangers (ClC-3 through ClC-7). Dysfunction of these anion transport proteins cause diverse human diseases including myotonia, aldosteronism, epilepsy, salt-wasting nephropathies with and without

vivo models, with a particular focus on living myocardial slice. In a translational perspective, human myocardial slices are also extensively used. The multicellular environment and preserved functionality [...] Methodology Myocardial slices (LMS) Myocardial slice preparation and ex vivo culture (mouse, rat, pig, human) Minituarization of LMS for high throughput approaches Isometric force measurement in LMS Calcium [...] and intracellular calcium transients (IonOptix, Coop Prof. T. Kraft, Dr. M. Ricke-Hoch) Models with human induced pluripotent stem cell-derived cardiomyocytes hiPSC-CM differentiation and culture (Coop Dr

Arbeitsgruppe werden zudem verschiedene Protokolle zur Isolierung und Transplantation von murinen und humanen Hepatozyten in Tiermodellen bzw. Xenotransplantationsmodellen entwickelt und optimiert. Die Projekte [...] Arbeitsgruppe werden zudem verschiedene Protokolle zur Isolierung und Transplantation von murinen und humanen Hepatozyten in Tiermodellen bzw. Xenotransplantationsmodellen entwickelt und optimiert. Die Projekte [...] Römermann, Dipl.-Biologin Denise Schlösser, PhD Studentin Josephin Scholz, Assistenzärztin Georgina Schumann, PhD Studentin Dr. rer. nat. Sven Schüngel, PhD-Student 2005 - 2010 Dr. med. Nora Schweitzer, A

Richter R, Eckert K, Henschler R, Wilkens L, Jochheim-Richter A, Aresniev L, Ott M: Human cord blood stem cells generate human cytokeratin 18-negative hepatocyte-like cells in injured mouse liver. Am J Pathol [...] Rudolph KL, Wilkens L: Telomere shortening correlates with increasing aneuploidy of chromosome 8 in human hepatocellular carcinoma. Hepatology 2005; 42(3): 522-6 Preda-Pais A, Stan AC, Casares S, Bona CA [...] Kreipe HH and Pich A: SELDI-MS-based expression profiling of ductal invasive and lobular invasive human breast carcinomas. Pathol Res Pract 2005; 201(12): 763-70 Verhulst A, Asselman M, De Naeyer S, Vervaet

Jordans S, Dilloo D. J Cell Mol Med 2022;26(23):5832-5845 DOI: 10.1111/jcmm.17604 Polarization of human iPSC-derived macrophages directs their immunological response to secondary pro-inflammatory stimuli [...] Hochschule Hannover, 2022 2021 Optimized Adeno-Associated Virus Vectors for Efficient Transduction of Human Retinal Organoids. Völkner M, Pavlou M, Büning H, Michalakis S, Karl MO. Hum Gene Ther 2021;32(13 [...] Galla M. Mol Ther Nucleic Acids 2022;27:810-823 DOI: 10.1016/j.omtn.2021.12.033 Improved targeting of human CD4+ T cells by nanobody-modified AAV2 gene therapy vectors. Hamann MV, Beschorner N, Vu XK, Hauber