interpretation. Therefore, a number of doctors from the department of pathology are recruited for service within xPa and cooperating scientist can expect to be counselled by a histopathologist, who has [...] Aims Within REBIRTH a completely new interdisciplinary service unit (xPa) has come into being, which combines veterinary expertise from the Institute for Laboratory Animals with histopathologic skills [...] optimal patho-anatomical interpretation of animal models for human disease and regeneration xPa provides a platform for information (modes of fixation and tissue banking), technical support (tissue sections

comprises several copies of a sensor component such as NLRP3 ( NLR family protein containing a pyrin domain 3 ), the adaptor ASC ( apoptosis-associated speck-like protein containing a caspase activation and [...] autoinhibited monomers or subdomains of NLRPs. A second core research area in our current research portfolio is the work on the large GTPase dynamin. Dynamin is a key protein in clathrin mediated endocytosis [...] endocytosis and numerous other membrane remodeling processes. Moreover, dynamin is a promising target for therapeutic intervention in chronic kidney diseases (CKDs). We want to provide the basis for novel strategies

31141694; PubMed Transformation of the Nonprocessive Fast Skeletal Myosin II into a Processive Motor. Amrute-Nayak M , Nayak A, Steffen W, Tsiavaliaris G, Scholz T, Brenner B. Small. 2019 Feb;15(7):e1804313 [...] regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Li X, Thome S, Ma X, Amrute-Nayak M , Finigan A, Kitt L, Masters L, James JR, Shi Y, Meng G, Mallat Z. Nat [...] myosin active site. Amrute-Nayak M , Lambeck KA, Radocaj A, Huhnt HE, Scholz T, Hahn N, Tsiavaliaris G, Walter WJ, Brenner B. Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2536-41. doi: 10.1073/pnas.1316390111

therefore excellent English skills are a basic requirement. Proficiency is to be attested by certificates (TOEFL, IELTS etc.) or a short statement showing that you are a native speaker or have carried out [...] here . Alumni Welcome Alumni! Alumni are important ambassadors for the university and you can play a role in furthering the university's goal of facing the future with knowledge across borders and boundaries [...] part in different alumni activities as well as contributing to the development of the University. Have a read of our Alumni Letters . As our Alumni Network grows we will strive to extend our services to you

derived from different tissues and prospective clinical applications a) Charakterisierung und Expansion der MSC durch in vitro Kultivierung a) characterization and expansion of MSC in vitro culture b) Diff [...] carcinoma) of patients following tumor surgery or biopsy a) molekulare Charakterisierung des Tumorzellwachstums und assoziierter Signalmechanismen a) molecular characterization of cancer cell proliferation [...] and generation of new cancer cell populations after fusion with MSC a) Charakterisierung der neuen Tumorzelltypen in vitro und in vivo a) characterization of new cancer cell populations in vitro and in vivo

Projects Allosteric regulation of UDP-sugar pyrophosphorylases as a means to develop new anti-parasitic treatments UDP-sugar pyrophosphorylases play a central role in cellular carbohydrate biosynthesis. As metabolic [...] innate immune sensors as a means to control infection and inflammation The innate immune sensors activate interferon-driven antiviral responses upon recognition of PAMPs and serve as a rheostat for the metabolic [...] development of new drugs against protozoan parasites. The current project pursues the goal to obtain a comprehensive description of the allosteric mechanisms regulating UDP-sugar pyrophosphorylases. This

Ines Pietschmann, M.mel (ehemals) Studentische Mitarbeit (MHH): Tatiana Hetzel, B.A. (ehemals) Ilvie Otto [Prince], B.A. (ehemals) Förderung: Niedersächsisches Ministerium für Wissenschaft und Kultur (MWK) [...] Kahrass (ehemals) Hélène Nobile, PhD Antje Schnarr, M.A. (ehemals) Doktoranden: Natali Lilie Randjbar Moshtaghin Studentische Mitarbeit: Zoë Lüddecke, B.A. (ehemals) Förderung: Hausmittel Laufzeit: Juni 2015 [...] Mertz Wissenschaftliche Mitarbeit: Dr. phil. Ilvie Prince Studentische Mitarbeit: Malte Thomalla, B.A. Förderung: Hausmittel Laufzeit: Mai 2024 bis voraussichtlich Mai 2026 EthU: Ethische Entscheidungsfindung

Zellen wehren sich mit dem Protein Apobec3A Das Team von Professorin Schreiner hat nun herausgefunden, dass die menschlichen Zellen sich mit Hilfe von Apobec3A gegen eine Adenovirus-Infektion wehren. „Wir [...] „Wir haben eine signifikante Hochregulierung von Apobec3A während einer HAdV-Infektion festgestellt“, sagt sie. Von dem Protein war bereits bekannt, dass es bei der Abwehr einer chronischen Hepatitis B [...] eine zentrale Rolle spielt. Die Forschenden konnten auch den Abwehr-Mechanismus aufklären: „Apobec3A verändert die molekulare Markierung mit dem SUMO-Protein an wichtigen viralen Faktoren.“ Das hat zur

outpatient palliative care in Germany and developing recommendations for improvement (Polite): A study protocol for a mixed-methods study. PLoS One 16 , e0256467. DOI: 10.1371/journal.pone.0256467 Faerber, C [...] Lengerke T. (2024). Human resource management to assist infection prevention and control professionals: a scoping review. J Hosp Infect, 148:145-154. DOI: 10.1016/j.jhin.2024.04.004. Ülgüt R , Stiel S, Herbst [...] FA. (2023). Experiences and support needs of informal long-distance caregivers at the end of life: A scoping review. BMJ Open, 13:e068175. DOI: 10.1136/bmjopen-2022-068175 Herbst FA, Ülgüt R , Stiel S

Regelungen und die Qualität der Studienergebnisse. ¹ www.arise-clinicaltrial.eu ² Horke A, Haverich A et al. Early results from a prospective, single-arm European trial on decellularized allografts for aortic valve [...] Registry Data. Eur J Cardiothorac Surg. 2020, in press. ³ Beckmann E, Martens A, Krueger H, Korte W, Kaufeld T, Haverich A, Shrestha ML. Aortic Valve-Sparing Root Replacement (David I Procedure) in Ad