valuable insights that link genetic mutations to molecular pathways, helping to develop targeted therapeutic strategies for individuals with (rare) genetic disorders. Research Focus Non-Muscle Actinopathies [...] uncovering the genetic foundations of these neurological changes to ultimately support tailored therapeutic approaches. Our interdisciplinary approach of medical expertise with direct connection to patients

efficiently block the activity of the receptor. The aim of this Master’s thesis is now to validate the therapeutic potential of these drugs in preclinical models of tauopathies. Your Tasks: Investigation of Tau

of blood cell formation and function with a special focus on genetic cell modification as a new therapeutic modality. Our research groups collaborate to form a portfolio ranging from the generation and expansion

Neuroepigenetics and RNA-based therapies) Animalfree model systems for the investigation of novel therapeutic approaches (AG Neuroepigenetics and RNA-based therapies; AG Advanced Tissue Culture Models) Biomimetic

competitive advantage of these mutant pre-leukemic cells remains poorly understood to date. Therefore, therapeutic interventions to prevent clonal evolution and ultimately blood cancer development have yet not [...] Aside from the expected insights into basic biological principles, this work is of potential therapeutic relevance, since small molecule inhibitors targeting oncogenic MLL1 complexes have recently been [...] clonal evolution is feasible. We hope that this work will be the basis for the development of therapeutic strategies that may help to prevent malignant transformation in patient at high risk in the future

The existing drugs against these organisms often pose problems of toxicity and the occurrence of therapeutic failures is frequent. The development of new drugs is needed and would clearly benefit from a deeper

paves the way for developing targeted interventions to mitigate cognitive decline and enhance therapeutic strategies for neurological conditions. Future Directions: The Institute of Neuroanatomy and Cell

further characterize the consequences of germline genetic variants and potentially define future therapeutic targets or preventive measures in cancer predisposing syndromes, we are conducting metabolomic

ver.de Telefon (0511) 532-9590. Die Originalarbeit „The co‐mutational spectrum determines the therapeutic response in murine FGFR2 fusion‐driven cholangiocarcinoma“ finden Sie hier .

provide you with help if you are seeking more "professional / psychological" advice. Psychological-therapeutic counselling at Leibniz University Hannover (also for MHH students) - individual or in a group