doi 10.1007/s00103-024-03875-9 Epping J, Tetzlaff F, Mond L, Tetzlaff J (2024). Healthy enough to work up to age 67 and beyond? A longitudinal population-based study on time trends in working life expectancy [...] (2023). Sind Prävalenzen in Survey- und Routinedaten vergleichbar? Gegenüberstellung von Herzinfarktprävalenzen in Krankenkassendaten der AOK Niedersachsen und in Daten der Studie zur Gesundheit Erwachsener [...] Perspektive" Arbeitsschwerpunkte Entwicklung der Morbidität mit Schwerpunkt Multimorbidität Datenaufbereitung und statistische Analysen Gesundheitliche Ungleichheit Lehre Modellstudiengang Medizin: Psy

Im KPS-Register werden sowohl Daten, Biomaterialien (Blut und Tumormaterial) als auch radiologische Bilder gesammelt. Registerleiter ist Prof. Dr. Christian Kratz . Die Daten werden bei der initialen Erhebung [...] Erhebung und bei dem jährlichen Follow-up erhoben. Blut und Tumorproben sowie radiologisches Bildmaterial werden nur dann an das Register weitergeleitet, wenn diese ohnehin im Rahmen der regulären Diagnostik

Hypertrophic cardiomyopathy has various manifestations from asymptomatic status or mild clinical symptoms up to heart failure and sudden cardiac death. Despite the given clinical relevance of HCM there is a lack [...] (ERT) has been shown to stabilize and reduce many symptoms of Fabry disease. Identifying ncRNAs as targets as well as the use of new analytical techniques in cardiac imaging (MRI) to better understand the [...] deficiency results in accumulation of globotriaosylceramide (Gb3) in different cells/tissues and leads to impairment of various organs such as eyes, skin, nerves, gastrointestinal system, kidneys and card

Ingelheim Stiftung im Rahmen ihres Programms Rise up! für innovative Grundlagenforschung über drei Jahre mit rund 600.000 Euro. Drei neue Kandidaten für RNA-basierte Therapie gefunden Seit acht Jahren [...] und die Leberschäden verringern ließen. Auf Basis seiner bisherigen Forschungsdaten möchte er nun weitere mRNA-Therapiekandidaten für leberspezifische Erkrankungen sowie nicht-kodierenden RNAs untersuchen [...] Leber identifiziert Im aktuellen Projekt möchte der Biomediziner die genaue Funktion dieser drei RNA-Kandidaten untersuchen und ihr Potenzial für eine RNA-basierte Therapie zur Behandlung von Leberfibrose

contraindication to its use. Occasional shortage of anesthesiologic manpower, especially during busy call hours, can often lead to delay of treatment. In cases were swift surgery is needed, in order to prevent [...] work-up. The mean CRP was 11,4mg/l (Reference CRP <5mg/l). Leukocyte mean count was 9,78Tsd/µl (SD 3,68). Post op the mean (n=7) CRP had risen to 23,9mg/l, while the leukocyte count had fallen to 7,87 [...] well as intraoperative occurrences. We also evaluated the need for revision surgery or necessity to convert to general anesthesia. Results: 9 of the patients were men, 7 were women. The average age was 45

und Grenzen von Befragungsdaten und Daten gesetzlicher Krankenversicherung, in Swart, E., Ihle, P., Matusiewicz, D. (Hrsg.). Routinedaten im Gesundheitswesen : Handbuch Sekundärdatenanalyse: Grundlagen, Methoden [...] https://doi.org/10.1007/s00103-024-03868-8 Epping J , Tetzlaff F, Mond L, Tetzlaff J. Healthy enough to work up to age 67 and beyond? A longitudinal population-based study on time trends in working life expectancy [...] Tetzlaff J (2021). Sind Prävalenzen in Survey- und Routinedaten vergleichbar? Herzinfarktprävalenzen in Krankenkassendaten der AOK Niedersachsen und in Daten der Studie zur Gesundheit Erwachsener in Deutschland

Cytometry gives rise to large, high-dimensional datasets which are increasingly difficult to analyze by manual gating. Therefore, frameworks for computational flow-cytometry have to be developed to analyze this [...] mining when it comes to orient oneself in bioethical debates. The idea is to create machines that can reliably discover arguments for and against some topic and thus are enabled to intelligently engage [...] statistical methods then most tools offer to date. While appropriate approaches are available in dedicated statistical programming languages, such as R, they are hard to handle for biomedical experts without

patients. The animal model is based on weight loss leading to hyperactivity. In addition to the chronic phase, the model incorporates a refeeding phase to investigate the processes that occur during underweight [...] subsequent weight gain, in a manner analogous to clinical treatment. The focus is on structural changes in the brain and cardiopulmonary system. In addition to structural changes, molecular markers that can [...] The aim is to identify changes that do not fully resolve, leaving a kind of scar as a form of bodily memory. Enhanced understanding of the pathophysiology will enable preventive measures to be introduced

aim to develop new assays for better preclinical risk assessment (Michael Rothe, Axel Schambach). To better understand the mechanisms driving cell transformation and to develop novel strategies to combat [...] novel tools for gene therapy and to systematically modify ES- and iPS- cells. Our vector platform has been successfully used to explore novel strategies to generate/regenerate and expand stem cells (Thomas [...] is also expected to improve our understanding of DNA repair in somatic stem cells. A major challenge of gene therapy is insertional transformation of hematopoietic stem cells due to up- or down-regulation

It is with great pleasure and deep gratitude that we welcome you to the symposium “Milestones and Horizons in Hepatology – A Tribute to Michael Manns” this June in Hannover. For 28 years, Michael Manns [...] and extraordinary commitment to mentorship, he built a truly unique and internationally recognized hepatology center here in Hannover. With this special symposium, we wish to honor Michael Manns and celebrate [...] contributions to the field, followed by presentations from a young Hannover-based faculty member highlighting current developments and ongoing research activities on our campus. In this way, we aim to connect