Our research focuses on unraveling fundamental immunological concepts of the mucosal immune system, particularly the immune responses in the intestine and its associated draining lymph nodes, the mesenteric lymph nodes. Disruptions of this intestinal immune system, triggered by genetic alterations or bacterial interactions, can lead to inflammatory and chronic diseases. The intact intestinal barrier is crucial as it constantly confronts our immune system with external influences such as allergens, microbes, and food antigens. Managing this complexity poses a challenge for both the innate and adaptive immune systems. It is crucial for the immune defense system to combat pathogens while maintaining tolerance to a variety of antigens. Failure of these tolerance mechanisms can lead to various diseases, such as inflammatory bowel diseases. Our research encompasses state-of-the-art techniques as well as in vitro and in vivo model systems to examine various cell types present in mucosal tissues at cellular and molecular levels.

Topic: Barrier Integrity

A central focus of our work lies on the intestinal barrier, consisting of various epithelial cell populations and being of critical importance. Disruptions of this epithelial barrier, whether through bacterial contact or genetic alterations, can lead to inflammation. Therefore, we investigate the role of genetic factors in maintaining the barrier, utilizing both intestinal organoids and a "Gut-on-a-Chip" system.

The use of intestinal organoids led to another goal, which is now being pursued by the EasyOrganoid innovation network. This network aims to facilitate the use of organoids in research and teaching - among other things, through a cost-effective, modular system for incubation and imaging, as well as accompanying e-learning offerings.

Topic: Stromal Cell Immunity

The mesenteric lymph nodes play a pivotal role in the intestinal immune system as they determine whether an immune reaction or tolerance to antigens is triggered. Of particular importance are the stromal cells, whose immunological function and interaction with other cells are not fully understood. We analyze stromal cells from various lymph nodes to better understand their commonalities and differences regarding immunological processes.