Disease Modeling Recreating diseases in a dish Disease modeling using human induced pluripotent stem cells (hiPSCs) is a powerful and evolving approach in biomedical research. Patient- or donor-derive
Living Organ Slices Our primary research focus is the advancement and refinement of the living myocardial slice (LMS) platform, a physiologically relevant model for studying cardiac function and disea
RNA-based therapeutics RNA molecules play a critical role in a wide range of biological processes, including the initiation and progression of diseases. As a result, RNA-based therapeutics have emerge
Lipid nanoparticles RNA therapeutics are rapidly emerging as a key therapeutic modality. However, a major challenge for broader application remains their specific delivery to target tissues and cells,
PROTACs Classical pharmacological inhibitors can only target a small subset of proteins mainly catalytically active enzymes. Therefore, the vast majority of the proteome remains undruggable including
Superparamagnetic nanoparticles The therapeutic potential of superparamagnetic nanoparticles has attracted great scientific interest. So far, research has been devoted to the concept of magnetic hyper
Safety & Drug Testing The cardiovascular system is regulated by a complex interplay of pressure dynamics, neurological signals, chemical compounds and other physiological factors. Consequently, treatm
Cardiac Regeneration & Aging Cardiac regeneration and aging influence cardiac function drastically. Our vision is to therapeutically exploit non-coding RNA (ncRNAs) and telomere biology to enhance mam
Targeted Delivery In recent years, tremendous progress has been made in the field of RNA-based therapeutics, and the first therapeutics have already been tested in clinical trials. Despite a large num