factor receptor-2 (FGFR2). In about 15 percent of patients with ICC, FGFR2 is fused, so to speak, with other genes due to a genetic malformation. These fusion rearrangements lead to a permanent activation [...] FGFR2," explains Dr. Saborowski. Such FGFR2 inhibitors have already been approved in the USA for ICC patients with FGFR2 fusion, for example, and the European regulatory authority has also given a positive [...] clinically inconspicuous for a long time, so that it is often only detected late. Because the tumour also only responds to chemotherapy to a limited extent, those affected often have a poor prognosis. For some

and outer hair cells develop before birth from a common type of precursor cells. Which factors control the different development was unknown for a long time. A research team led by Professor Dr. Andreas Kispert [...] molecular biologist. Tbx2 regulates development into inner and outer hair cells In their investigations, the research team focused on the gene Tbx2. It contains the information for a so-called transcription [...] also shown at a later stage of development. "If Tbx2 is deactivated in the inner hair cells, they transform into outer hair cells," the scientist explains. "Conversely, activation of Tbx2 in the outer hair

can benefit from SSO2 therapy. It is used in the event of an acute heart attack, directly after the previously occluded coronary vessel has been reopened through a catheter. During SSO2 therapy, cardiologists [...] - for the first time in Europe - the new SuperSaturated Oxygen (SSO2) therapy to reduce the extent of heart attacks. The procedure is a therapy already approved in the United States. It was newly approved [...] to combat muscle breakdown A heart attack occurs when the blood flow and thereby the oxygen supply to the heart is disturbed. Despite reopening of the coronary artery through a heart catheter, many patients

that variants in BRCA1/2 or an MMR gene lead to childhood cancer is statistically significantly increased, but still in such a low range that the detection of such a variant in a healthy child would currently [...] that pathogenic variants in BRCA1/2 and the MMR genes may also contribute to the risk of cancer in individuals below age 18 years. "Children and adolescents with BRCA1/2 or MMR gene variants were mainly [...] Haematology and Oncology. The international research team conducted a meta-analysis based on 11 studies that included results on germline testing of a total of 3,775 children and adolescents suffering from cancer

can bind precisely to a protein called P2Y14 as so-called ligands. "We have found the P2Y14 receptor primarily in the liver stellate cells," explains the physician. P2Y14 receptor as a link between cell death [...] are a significant medical problem for which there are as yet no suitable drugs. The best-known causes include chronic alcohol consumption, infection with hepatitis viruses, but also medication or a fatty [...] signalling pathway between P2Y14 ligands and receptor. An increased release of these activated sugar molecules led to the activation of stellate cells. Inactivation of the P2Y14 receptor, on the other hand

receiving care at a specialized treatment center run by the Neuromyelitis Optica Study Group (NEMOS, www.nemos-net.de). "In summary, we can state that it is a great advantage for patients with a rare disease [...] reported having passed through a SARS-CoV-2 infection, which was mostly mild. The vaccination rate of the patients was very high: 89 percent were fully vaccinated against SARS-CoV-2. The authors of the study [...] was a temporal relationship between vaccination and the initial manifestation of disease or a disease flare. "Further studies are certainly needed here to clarify whether vaccination really has a causal

in patients with so-called FGFR2 fusions. FGFR2 is a fibroblast growth factor receptor-2. In bile duct tumours, FGFR2 is fused, so to speak, with other genes due to a genetic malformation. These fusion [...] of Hannover Medical School (MHH) and member of the ESMO Steering Committee played a major role in the update: "From a systemic perspective, there are three significant changes that affect all levels of [...] present, there is only a chance of cure with early-stage surgery, although unfortunately many patients are not operable when they are first diagnosed," explains Professor Vogel, who is a senior consultant in

by COVID-19: "Last year we treated 239 people for a SARS-CoV-2 infection in an intensive care unit, almost 500 patients were treated with a SARS-CoV-2 infection in normal wards," said Professor Lammert [...] can handle such a pandemic situation excellently," emphasised President Professor Dr Michael Manns on Friday (15 July 2022) during the balance sheet press conference. "We have mastered a wide range of demands [...] SARS-CoV-2/COVID-19. And our lecturers have successfully balanced presence and online teaching." Turnover of almost one billion euros The economic result for the year of -13 million euros on a turnover

against SARS-CoV2 in employees of the MHH and affiliated institutions. "Our data can also make a significant contribution to better understanding the long-term immune response against SARS-CoV-2 and assessing [...] triggers a defence reaction and develops immune protection. Unlike last season's bivalent vaccines, the new vaccines only contain mRNA of the Omikron variant. "The new boosters nevertheless activate a backward [...] on Vaccination ( Stiko ), a booster vaccination with the new, adapted vaccine is recommended for everyone aged 60 or over. In addition, all people who are at particular risk of a severe course of the disease

search for a needle in a haystack. There are probably an estimated 20,000 to 30,000 different circRNAs in our cells, and only about ten are known to date about their mode of action. In a first step, a circRNA [...] can no longer pump at its full capacity. "There is a risk that after the treatment the tumour is gone, but the heart is permanently damaged." Too low a dosage, on the other hand, increases the risk that [...] But SARS-CoV-2 also attacks the heart muscle. "In up to ten per cent of severely affected COVID-19 sufferers, new heart failure that was not present before the infection can occur within a year because