usually tested in the mouse model before they are used on patients. "This is lengthy, and unfortunately not always very conclusive," the scientist emphasises. The IVIM (In Vitro Immortalisation) test developed [...] Institute of Experimental Haematology at the Hannover Medical School (MHH) has developed a safety test that can accurately predict the potential cancer risk of retroviral vectors. The research results [...] Canada, Australia and Europe already detects problematic vectors in cell culture. But the new safety test can do even more. The scientists discovered that genotoxic vectors specifically alter the conversion

clinic. “So we have already tested the principle,” says the rheumatologist. Saving time for patients and medical staff In the “Blut mobil” project, the process is now to be tested for its suitability for everyday [...] permanent specialist care and must regularly introduce themselves personally to the practice. Blood tests are often the only reason for the appointment. This is particularly problematic in rural areas, where [...] School (MHH) . In cooperation with the University Medical Center Göttingen , they want to develop and test a new concept whereby chronically ill patients can take a small amount of blood themselves at home

screening. Prerequisite: an elevated risk profile for lung cancer. Since then, over 600 people have been tested for lung cancer at the Hannover site. One of these is the 72-year-old Gerhard Lunow. For him, the [...] team from the Institute of Diagnostic and Interventional Radiology and the Pneumology Clinic. The test subjects are examined using modern and gentle low-dose computer tomography (CT). In this way, lung [...] lung tumors can be detected at an early stage and the mortality rate from lung cancer reduced. The test is carried out in a mobile study truck, which alternates between the three study sites, Hannover, Lübeck

met the LFS genetic testing criteria had a higher incidence of early adrenal, brain, connective tissue and bone tumors, whereas TP53 variant carriers who did not meet the genetic testing criteria had a higher [...] Differences in tumor characteristics Of the 3,034 people, 2,139 (70.5 per cent) met the LFS genetic test criteria or developed cancer before the age 18 years. 149 people (4.9 per cent) were unaffected carriers [...] carriers and blood relatives of these patients. 678 persons (22.3 per cent) did not meet the LFS genetic test criteria and did not develop cancer before the age 18 years. 33 people (1.1 per cent) were cancer-free

developed by the research group must now first be confirmed in further preclinical tests. After that, the scientists plan to test the efficacy in a clinical trial on ICC patients in Germany. [...] significantly to tumour growth. "We can reliably identify such fusion-positive ICC patients by genetic tests on tumour material and treat them with drugs that block FGFR2," explains Dr. Saborowski. Such FGFR2

Developing replacement and supplementary methods for animal experiments and thus avoiding animal testing is the goal of the "Micro-Replace Systems" research network led by Professor Dr. André Bleich, Director [...] experiments. Stem cells grow into mini organs The network is primarily concerned with reducing animal testing in basic research. "It is precisely there that the number of animal experiments has been constant [...] information on how research is currently working to reduce, improve or completely replace animal testing, visit https://www.3r-forschung.de/ .

virus needs for its reproduction," says Professor Schambach. Efficacy of RNAi candidates successfully tested in lung tissue The RNAi technology uses molecular methods to attack the Achilles' heel of the viruses [...] cted development pipeline, this process could be shortened to a few weeks. "We have successfully tested the efficacy of our RNAi candidates on human lung tissue sections as well as in 3D cell cultures [...] for other virus types In the next step, the efficiency and safety of the RNAi candidates will be tested in animal models. In addition, the RNA therapeutic agent is not to be administered with a syringe

blood plasma. The two AAV variants also survived this test. They were then loaded with a biomolecule called H19, which has already been successfully tested at the Institute for the treatment of pathological [...] in the heart and hardly ever stray into the liver. "We had several winners in the running and then tested how strongly they were intercepted by the human immune system." Not all gene taxis reach their target

the largest German programme to date for the early detection of lung cancer starts with over 12,000 test persons. Three lung centres in northern Germany and the prominent doctor and patron of the study, [...] and effectiveness of a model-based versus a conventional risk assessment for lung cancer is being tested. Since people with an increased risk of lung cancer in particular benefit from a screening programme [...] tenth of the average annual natural radiation in Germany. With this gentle imaging procedure, the test persons receive detailed information regarding any lung cancer that may be present and can then receive

Evidence-based online treatments are an effective alternative. But although four such scientifically tested programmes are now available in Germany, they are only used by less than one percent of those affected [...] scientifically based technology acceptance model. In a second step, the findings will be quantitatively tested on 5,000 people with depressive disorders. The aim is to adapt future programmes to the needs of