the pathological accumulation of the tau protein. The effect of amisulpride has been successfully tested in various cellular models as well as in animal models of dementia. The results have now been published [...] Centre for Neurodegenerative Diseases in Magdeburg, we are preparing a Phase II clinical trial to test the effect of amisulpride in the treatment of patients with dementia," explains Professor Ponimaskin
similar approach in a new multicenter study. This will involve combining one of the drugs already being tested with another agent that has so far been used to treat anemia associated with chronic kidney disease [...] cultures and in mouse models. Now the efficacy, safety and tolerability of the new therapy are to be tested in a human clinical trial. Subjects are still being sought for this purpose. "We expect that treatment
therefore frequently detected late. The lecture explains how to identify at-risk individuals , which tests are useful for early detection, and what measures help slow the progression of the disease—including
million have liver inflammation; and up to 1 million already have cirrhosis. Who needs which diagnostic tests, and what treatment options are available—ranging from a liver-healthy diet to newly approved medications
research. Before new vaccines are launched on the market, they have to undergo extensive clinical testing. The requirements for a clinical trial are high, the bureaucratic effort for planning and implementation [...] with more than 2,000 participants aged 60 and older during the Corona pandemic at a total of twelve test centers nationwide and investigated the effect of VPM1002 vaccination on the clinical course of upper
it on the way. "We have already developed such an LV system in the iHEAR project and successfully tested it in the mouse model against hearing disorders and dizziness," the scientist notes. In the MY-O-SENSES [...] ve cure with the least amount of genetic material. If everything works, the gene therapy will be tested in clinical trials on humans at the end of the project. Professor Schambach is certain that the procedure
impact,” says the molecular physician. In order to find the best CAR candidate, the researchers are testing various immune switches that, in addition to hyperactivation, are also supposed to prolong the survival [...] Schambach. If suitable candidates for the immune switches are found, the hyperactivated NK cells are tested for their efficacy and safety. This is done in cell culture, in surgically removed tumour tissue
needed for this severe liver disease," emphasises the liver expert. In the current study, the drug was tested on a larger number of patients to see whether efficacy and safety could be confirmed in many different [...] existence, because for its continued existence in the body it must always infect new liver cells. "We tested the antiviral activity on 150 patients who were infected with both HBV and HDV," says Professor Cornberg
virus needs to replicate," says Professor Schambach. Effectiveness of RNAi candidates successfully tested in lung tissue RNAi technology uses molecular methods to target the Achilles' heel of viruses, so [...] development pipeline, this process could be shortened to just a few weeks. "We have successfully tested the efficacy and safety of our RNAi candidates on human lung tissue slices and in 3D cell cultures
and emergency medicine specialist. Large area with the smallest possible volume The next step is to test whether the endothelial cells adhere firmly enough to the artificial surfaces and can withstand the [...] laboratory conditions using artificially generated blood circuits. In a next step, they will then be tested first as a respiratory acute aid and later as a permanent lung alternative in animal models. However