inner and outer hair cells develop before birth from a common type of precursor cells. Which factors control the different development was unknown for a long time. A research team led by Professor Dr. Andreas [...] Molecular Biology at the Hannover Medical School (MHH) has now found the key and demonstrated how it controls the process: The gene Tbx2 acts like a switch to determine whether inner or outer hair cells are [...] help renew the auditory sensory cells. "But for this, it is imperative to understand which genes control the formation of hair cells during embryonic development," emphasises the molecular biologist. Tbx2

For example, it is not yet known why up to 50 percent of those affected are spontaneously able to control the multiplication of the hepatitis D viruses in the body. Questions also remain as to why some patients [...] well as reduce healthcare costs caused by HDV infections. Once the key clinical questions of viral control, disease progression and response to antiviral treatment are answered, the findings could serve as [...] as a blueprint for personalised infectious medicine and help bring other viral diseases under control. SERVICE: For more information, contact Professor Dr Heiner Wedemeyer, wedemeyer.heiner@mh-hannover

research, and is supporting the project with 2.5 million euros over five years. Ring-shaped RNA controls processes in body cells In his project, the scientist focuses on so-called circular RNAs (circRNA) [...] heart In the REVERSE project, Professor Thum and his research team will first look for circRNAs that control the cardiac remodelling process. This side effect on the heart is caused, for example, by certain [...] screening procedure. The cardiologist then wants to check whether the selected RNA structures actually control the cardiac remodelling in each case. To do this, the research team uses the method of "living heart

years with more than half a million euros. Signalling protein MAVS and interferon-alpha cascade control virus defence In earlier work with other viruses that can also attack heart muscle cells, the researchers [...] invaders. The tissue hormone interferon-alpha apparently plays an important role in this. It is controlled by the mitochondrial antiviral signalling protein (MAVS), which is essential for innate antiviral [...] muscle cells. These are then infected with the coronavirus. "We want to find out which proteins control interferon-alpha signalling in acute disease and in long- and post-COVID. They also want to clarify

00 Euros. Affected persons with moderate to severe symptoms sought The DGfN has been calling for controlled studies on the benefits of the therapy for some time. "In contrast to previous case studies, our [...] from the blood by immunoadsorption in some of the participants," says Dr. Gödecke. Although the control group apparently undergoes the same mechanical procedure, here the blood is returned to the body [...] randomly selected and do not know themselves whether they will be treated in the immunoadsorption or control group. "This allows us to detect possible placebo effects," the nephrologist explains. However, the

production of proteins, but control certain processes in the cells. In the ERC project LONGHEART, the research team discovered a specific lncRNA called Meg3, which controls fibrosis formation in heart

targeted gene correction. The work has been published in the renowned journal Nature Communications. Control of iron absorption defective "In most cases, iron storage disease is due to a defect in the haem [...] a protein building block - in the HFE protein. As a result, the HFE protein loses its ability to control iron absorption into the intestinal cells. In order to empty the iron stores and normalise the iron [...] correction was twelve percent. "This is a great success, because most genetic diseases can already be controlled if five percent of the cells have the correct gene," emphasises Dr. Alice Rovai, first author of

supply increases, the risks of addiction also increase." Participants learn strategies for self-control People who are addicted to gambling tend to suppress their addiction problem. They are often reluctant [...] advanced stage. In group therapy, the men and women affected learn to develop strategies for self-control and to reduce their behavioral excesses. The therapy consists of eight modules of so-called metacognitive

addiction refers to the derailed use of online games over which those affected increasingly lose control. School, work and social contacts are neglected in favour of excessive online gaming," reports Prof [...] am without making an appointment. In the group therapies, among other things, strategies for self-control and reduction of behavioural excesses are built up, but it is also about dealing with relapses or

research team has not only elucidated the production path itself, but also described the enzymes that control this process. “We have now for the first time comprehensively understood how the bacterium builds [...] is crucial for the development of antibacterial agents and for the discovery of new enzymes that control how bacteria cheat our immune system and how infectious they are. The researchers were also able