Publikationen

Dissertationen, Master- und Bachelorarbeiten

Link zu den Dissertationen, Master- und Bachelorarbeiten des Instituts

Unsere Publikationen (2016-2021)

2021

Andersen JB, Hultqvist LD, Jansen CU, Jakobsen TH, Nilsson M, Rybtke M, Uhd J, Fritz BG, Seifert R, Berthelsen J, Nielsen TE, Qvortrup K, Givskov M, Tolker-Nielsen T. Identification of small molecules that interfere with c-di-GMP signaling and induce dispersal of Pseudomonas aeruginosa biofilms. NPJ Biofilms Microbiomes. 2021; 7(1):59. doi: 10.1038/s41522-021-00225-4.

Slavik KM, Morehouse BR, Ragucci AE, Zhou W, Ai X, Chen Y, Li L, Wei Z, Bähre H, König M, Seifert R, Lee ASY, Cai H, Imler JL, Kranzusch PJ. cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila. Nature. 2021. doi: 10.1038/s41586-021-03743-5. Online ahead of print.

Bünsow D, Tantawy E, Ostermeier T, Bähre H, Garbe A, Larsen J, Winstel V. Methicillin-resistant Staphylococcus pseudintermedius synthesizes deoxyadenosine to cause persistent infection. Virulence. 2021; 12(1):989-1002. doi: 10.1080/21505594.2021.1903691.

Dorado-Morales P, Martínez I, Rivero-Buceta V, Díaz E, Bähre H, Lasa I, Solano C. Elevated c-di-GMP levels promote biofilm formation and biodesulfurization capacity of Rhodococcus erythropolis. Microb Biotechnol. 2021; 14(3):923-937. doi: 10.1111/1751-7915.13689.

Harloff M, Prüschenk S, Seifert R, Schlossmann J. Activation of soluble guanylyl cyclase signalling with cinaciguat improves impaired kidney function in diabetic mice. Br J Pharmacol. doi: 10.1111/bph.15425. Online ahead of print.

Krüger L, Herzberg C, Wicke D, Bähre H, Heidemann JL, Dickmanns J, Schmitt K, Ficner R, Stülke J.. A meet-up of two second messengers: the c-di-AMP receptor DarB controls (p)ppGpp synthesis in Bacillus subtilis. Nat Commun. 2021; 12: 1210. 

Neumann J, Grobe JM, Weisgut J, Schwelberger HG, Fogel WA, Marušáková M, Wache H, Bähre H, Buchwalow IB, Dhein S, Hofmann B, Kirchhefer U, Gergs U. Histamine can be Formed and Degraded in the Human and Mouse Heart. Front Pharmacol. 2021; 12:582916. doi: 10.3389/fphar.2021.582916.

Neumann D, Seifert R. Probiotics in Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol. 2021. doi: 10.1007/s00210-021-02110-5. Online ahead of print.

Oeser S, Wallner T, Nils S, Bučinská L, Sivabalasarma S, Bähre H, Albers SV, Wilde A. Minor pilins are involved in motility and natural competence of the cyanobacterium Synechocystis sp. PCC 6803. Mol Microbiol. 2021; doi: 10.1111/mmi.14768. Online ahead of print.

Ring J, Beyer K, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller A, Hoffmann F, Huttegger I, Jakob T, Klimek L, Kopp MV, Kugler C, Lange L, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stöcker B, Treudler R, Vogelberg C, Werfel T, Worm M, Sitter H, Brockow K. Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update: S2k-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Medical Association of German Allergologists (AeDA), the Society of Pediatric Allergology and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DAAU), the German Professional Association of Pediatricians (BVKJ), the Society for Neonatology and Pediatric Intensive Care (GNPI), the German Society of Dermatology (DDG), the Austrian Society for Allergology and Immunology (ÖGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Respiratory Society (DGP), the patient organization German Allergy and Asthma Association (DAAB), the German Working Group of Anaphylaxis Training and Education (AGATE). Allergo J Int 2021. Online ahead of print.

Rodriguez-Garcia E, Zabaleta N, Gil-Farina I, Gonzalez-Aparicio M, Echeverz M, Bähre H, Solano C, Lasa I, Gonzalez-Aseguinolaza G, Hommel M. AdrA as a Potential Immunomodulatory Candidate for STING-Mediated Antiviral Therapy That Required Both Type I IFN and TNF-α Production. J Immunol. 2021 Jan; 206: 376-385

Schirmer B, Neumann D. The Function of the Histamine H4 Receptor in Inflammatory and Inflammation-Associated Diseases of the Gut. Int J Mol Sci. 2021; 22(11):6116. doi: 10.3390/ijms22116116.

Seifert R. How Naunyn-Schmiedeberg's Archives of Pharmacology deals with fraudulent papers from paper mills. 
Naunyn Schmiedebergs Arch Pharmacol. 2021. Online ahead of print.

Seifert R, Schirmer B. Why Naunyn-Schmiedeberg's Archives of Pharmacology abandons traditional names of drug classes. Naunyn Schmiedebergs Arch Pharmacol. 2021; 394(7):1321-1325. doi: 10.1007/s00210-021-02111-4.

Seifert R, Schirmer B. A case to stop the use of the term 'antibiotics'. Trends Microbiol. doi: 10.1016/j.tim.2021.03.017. Online ahead of print.

Winterhoff M, Chen F, Sahini N, Ebensen T, Kuhn M, Kaever V, Bähre H, Pessler F. Establishment, Validation, and Initial Application of a Sensitive LC-MS/MS Assay for Quantification of the Naturally Occurring Isomers Itaconate, Mesaconate, and Citraconate. Metabolites. 2021; 11(5):270. doi: 10.3390/metabo11050270.

Worm M, Ring J, Klimek L, Jakob T, Lange L, Treudler R, Beyer K, Werfel T, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller AR, Hoffmann F, Huttegger I, Kopp MV, Kugler C, Lommatzsch M, Pfaar O, Rietschel E, Ruëff F, Schnadt S, Seifert R, Stöcker B, Vogelberg C, Sitter H, Gieler U, Brockow K. Management des Anaphylaxie-Risikos bei Covid-19-Impfung. HNO Nachr. 2021; 51(1):18-21. doi: 10.1007/s00060-021-7480-3.

Worm M, Ring J, Klimek L, Jakob T, Lange L, Treudler R, Beyer K, Werfel T, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller AR, Hoffmann F, Huttegger I, Kopp MV, Kugler C, Lommatzsch M, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stöcker B, Vogelberg C, Sitter H, Gieler U, Brockow K. Covid-19 vaccination and risk of anaphylaxis - Recommendations for practical management. MMW Fortschr Med 2021; 163:48-51

 

2020

Chaturvedi A, Goparaju R, Gupta C, Weder J, Klünemann T, Araujo Cruz MM, Kloos A, Goerlich K, Schottmann R, Othman B, Struys EA, Bähre H, Grote-Koska D, Brand K, Ganser A, Preller M, Heuser M. In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site. Leukemia 2020; 34: 416-426.

Costamagna D, Duelen R, Penna F, Neumann D, Costelli P, Sampaolesi M. Interleukin-4 administration improves muscle function, adult myogenesis, and lifespan of colon carcinoma-bearing mice. Cachexia Sarcopenia Muscle 2020; 11: 783-801.

de Araujo LS, Pessler K, Sühs KW, Novoselova N, Klawonn F, Kuhn M, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F. Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis. J Transl Med 2020 18: 9.

Gibhardt J, Heidemann JL, Bremenkamp R, Rosenberg J, Seifert R, Kaever V, Ficner R, Commichau FM. An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes. Environ Microbiol 2020; 22: 2771-2791

Latoscha A, Drexler DJ, Al-Bassam MM, Bandera AM, Kaever V, Findlay KC, Witte G, Tschowri N. c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria. Proc Natl Acad Sci U S A. 2020; 117:7392-7400.

Liu Y, Lee C, Li F, Trček J, Bähre H, Guo RT, Chen CC, Chernobrovkin A, Zubarev R, Römling U. A Cyclic di-GMP Network Is Present in Gram-Positive Streptococcus and Gram-Negative Proteus Species. ACS Infect Dis 2020; 6: 2672–2687. 

Schäfer H, Beckert B, Frese CK, Steinchen W, Nuss AM, Beckstette M, Hantke I, Driller K, Sudzinová P, Krásný L, Kaever V, Dersch P, Bange G, Wilson DN, Turgay K. The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis. PLoS Genet 2020; 16: e1008275

Schimmel K, Jung M, Foinquinos A, San José G, Beaumont J, Bock K, Grote-Levi L, Xiao K, Bär C, Pfanne A, Just A, Zimmer K, Ngoy S, López B, Ravassa S, Samolovac S, Janssen-Peters H, Remke J, Scherf K, Dangwal S, Piccoli MT, Kleemiss F, Kreutzer FP, Kenneweg F, Leonardy J, Hobuß L, Santer L, Do QT, Geffers R, Braesen JH, Schmitz J, Brandenberger C, Müller DN, Wilck N, Kaever V, Bähre H, Batkai S, Fiedler J, Alexander KM, Wertheim BM, Fisch S, Liao R, Diez J, González A, Thum T. Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation 2020; 141: 751-767.

Schirmer B., Neumann B. Cytokines. In: Nijkamp and Parnham's Principles of Immunopharmacology. Parnham, Michael J., Nijkamp, Frans P., Rossi, Adriano (Eds.). Springer International Publishing.

Schirmer B., Giehl, K., Kubatzky, K.F. Report of the 23rd Meeting on Signal Transduction 2019-Trends in Cancer and Infection. Int J Mol Sci 2020, 21: E2728.

Schirmer B, Lindemann L, Bittkau KS, Isaev R, Bösche D, Juchem M, Seifert R, Neumann D. Mouse Colonic Epithelial cells functionally express the histamine H4 receptor. J Pharmacol Exp Ther 2020; 373:167-174.

Schirmer B, Rother T, Bruesch I, Bleich A, Werlein C, Jonigk D, Seifert R, Neumann D. Genetic Deficiency of the Histamine H4-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice. Cancers (Basel) 2020; 12: pii: E912.

Schneider EH, Hofmeister O, Kälble S, Seifert R. Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells. Naunyn Schmiedebergs Arch Pharmacol 2020; 393: 1251-1267

Seifert R, Schirmer B. A Simple Mechanistic Terminology of Psychoactive Drugs: A Proposal. Naunyn Schmiedebergs Arch Pharmacol 2020; 393: 1331-1339

Thibeaux R, Soupé-Gilbert ME, Kainiu M, Girault D, Bierque E, Fernandes J, Bähre H, Douyère A, Eskenazi N, Vinh J, Picardeau M, Goarant C. The Zoonotic Pathogen Leptospira Interrogans Mitigates Environmental Stress Through cyclic-di-GMP-controlled Biofilm Production. NPJ Biofilms Microbiomes 2020; 6: 24.

Thöming JG, Tomasch J, Preusse M, Koska M, Grahl N, Pohl S, Willger SD, Kaever V, Müsken M, Häussler S.
Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype. 
NPJ Biofilms Microbiomes. 2020; 6: 2.

Wallner T, Pedroza L, Voigt K, Kaever V, Wilde A. The cyanobacterial phytochrome 2 regulates the expression of motility-related genes through the second messenger cyclic di-GMP. Photochem Photobiol Sci 2020; 11:783-801 

 

2019

Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C6, Davies JA; CGTP Collaborators (Beuve A, Boison D, Brouckaert P, Burnett JC, Burns K, Dessauer C, Friebe A, Garthwaite J, Gertsch J, Helsby N, Izzo AA, Koesling D, Kuhn M, Ostrom R, Papapetropoulos A, Potter LR, Pyne NJ, Pyne S, Russwurm M, Schmidt HH, Seifert R, Stasch JP, Szabo C, van der Stelt M, van der Vliet A, Watts V.) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol 2019; 176: S297-S396.

Braun F, Thomalla L, van der Does C, Quax TEF, Allers T, Kaever V, Albers SV. Cyclic nucleotides in archaea: Cyclic di-AMP in the archaeon Haloferax volcanii and its putative role. Microbiologyopen 2019; e829.

Chen F, Lukat P, Iqbal AA, Saile K, Kaever V, van den Heuvel J, Blankenfeldt W, Büssow K, Pessler F. Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proc Natl Acad Sci U S A 2019; 116: 20644-20654

Grobe S, Doberenz S, Ferreira K, Krueger J, Brönstrup M, Kaever V, Häußler S. Identification and quantification of (t)RNA modifications in Pseudomonas aeruginosa by liquid chromatography-tandem mass spectrometry. Chembiochem 2019; 20: 1430-1437.

Koppenhöfer S, Wang H, Scharfe M, Kaever V, Wagner-Döbler I, Tomasch J. Integrated Transcriptional Regulatory Network of Quorum Sensing, Replication Control, and SOS Response in Dinoroseobacter shibae. Front Microbiol 2019; 10: 803.

Kordes A, Grahl N, Koska M, Preusse M, Arce-Rodriguez A, Abraham WR, Kaever V, Häussler S. Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host. ISME J 2019; 13: 2018-2030.

Kuhla B, Kaever V, Tuchscherer A, Kuhla A. Involvement of plasma endocannabinoids and the hypothalamic endocannabinoid system in increasing feed intake after parturition of dairy cows. Neuroendocrinology 2019 [Epub ahead of print]

Li F, Cimdins A, Rohde M, Jänsch L, Kaever V, Nimtz M, Römling U. DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in Escherichia coli ECOR31. MBio 2019; 10: pii: e02492-18.

Melzer C, Rehn V, Yang Y, Bähre H, von der Ohe J, Hass R. Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells. Cancers (Basel). 2019; 11: pii: E798.

Nicholls TJ, Spåhr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM. Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria. Mol Cell 2019; 76: 784-796

Perduns R, Volk J, Plum M, Gutzki F, Kaever V, Geurtsen W. Effects of HEMA on Nrf2-related gene expression using a newly developed 3D co-culture model of the oral mucosa. Dent Mater 2019; pii: S0109-5641.

Ratuszny D, Sühs KW, Novoselova N, Kuhn M, Kaever V, Skripuletz T, Pessler F, Stangel M. Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis. Int J Mol Sci 2019; 20: pii: E337.

Rossmann FM, Rick T, Mrusek D, Sprankel L, Dörrich AK, Leonhard T, Bubendorfer S, Kaever V, Bange G, Thormann KM. The GGDEF domain of the phosphodiesterase PdeB in Shewanella putrefaciens mediates recruitment by the polar landmark protein HubP. J Bacteriol 2019; pii: JB.00534-18.

Sayner SL, Choi CS, Maulucci ME, Ramila, KC, Zhou C, Scruggs AK, Yarbrough T, Blair LAH, King JAC, Seifert R, Kaever V, Bauer NN. Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate (cAMP). Am J Physiol Lung Cell Mol Physiol 2019; 316: L691-L700.

Schwabe U, Seifert R. Parkinsonmittelhandlung der multiplen Sklerose. In: Arzneiverordnungsreport 2019; Hrsg. Schwabe U, Paffrath, D, Ludwig WD, Klauber J; Springer-Verlag Deutschland.

Scharrenbroich J, Kaever V, Dove S, Seifert R, Schneider EH. Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode. Naunyn Schmiedebergs Arch Pharmacol 2019; 392: 199-208.

Schirmer B, Giehl K, Kubatzky KF. Report of the Signal Transduction Society Meeting 2018-Signaling: From Past to Future. Int J Mol Sci. 2019; 20: pii: E227.

Schneider EH. Microglial histamine H4R in the pathophysiology of Parkinson's disease-a new actor on the stage? Naunyn Schmiedebergs Arch Pharmacol; 392: 641-645

Seifert R. Basic Knowledge of Pharmacology. Springer International Publishing, 492 Seiten

Seifert R, Günther J, Berlit P. Pharmakologische Behandlung der multiplen Sklerose. In: Arzneiverordnungsreport 2019; Hrsg. Schwabe U, Paffrath, D, Ludwig WD, Klauber J; Springer-Verlag Deutschland.

Sperling L, Mulero Alegría MD, Kaever V, Curtis PD. Analysis of Brevundimonas subvibrioides developmental signaling systems reveals inconsistencies between phenotypes and c-di-GMP levels. J Bacteriol 2019; pii: JB.00447-19

Sühs KW, Novoselova N, Kuhn M, Seegers L, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F. Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections. J Infect Dis 2019; 220: 127-138.

Wissig J, Grischin J, Bassler J, Schubert C, Friedrich T, Bähre H, Schultz JE, Unden G. CyaC, a redox-regulated adenylate cyclase of Sinorhizobium meliloti with a quinone responsive diheme-B membrane anchor domain. Mol Microbiol 2019; 112: 16-28.

 

2018

Kloth C, Schirmer B, Munder A, Stelzer T, Rothschuh J, Seifert R. The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model. Toxins (Basel). 2018;10: pii: E185.

Kuhn M, Sühs KW, Akmatov MK, Klawonn F, Wang J, Skripuletz T, Kaever V, Stangel M, Pessler F. Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation. J Neuroinflammation 2018; 15: 20.

Müsken M, Pawar V, Schwebs T, Bähre H, Felgner S, Weiss S, Häussler S. Breaking the Vicious Cycle of Antibiotic Killing and Regrowth of Biofilm-Residing Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2018; 62: pii: e01635-18.

Munder A, Rothschuh J, Schirmer B, Klockgether J, Kaever V, Tümmler B, Seifert R, Kloth C. The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates. Open Biol 2018; 8: pii: 170250.

Ostermeyer J, Golly F, Kaever V, Dove S, Seifert R, Schneider EH. cUMP hydrolysis by PDE3B. Naunyn Schmiedebergs Arch Pharmacol 2018; 391: 891-905

Schäper S, Yau HCL, Krol E, Skotnicka D, Heimerl T, Gray J, Kaever V, Søgaard-Andersen L, Vollmer W, Becker A. Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales. PLoS Genet. 2018; 14: e1007594.

Schirmer B, Bringmann L, Seifert R, Neumann D. In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4-Receptor: Adoptive Transfer Experiments Using Eosinophils From H4R-/- and H4R+/+ Mice. Front Immunol 2018; 9: 2119.

Schirmer B, Giehl K, Kubatzky KF. Report of the Signal Transduction Society Meeting 2017—Metabolism in Health and Disease. Int J Mol Sci 2018; 19: 549

Seifert R. Basiswissen Pharmakologie. 494 Seiten. Springer, Berlin, Heidelberg

Seifert R. Rethinking Pharmacological Nomenclature. Trends Pharmacol Sci 2018; 39: 785-797

Seifert R. Act Immediately Upon Onset of Symptoms. Dtsch Arztebl Int. 2018; 115: 748.

Zhang Y, Sass A, Van Acker H, Wille J, Verhasselt B, Van Nieuwerburgh F, Kaever V, Crabbé A, Coenye T. Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels. Front Microbiol. 2018; 9:1952.

 

2017

Abeln M, Borst KM, Cajic S, Thiesler H, Kats E, Albers I, Kuhn M, Kaever V, Rapp E, Münster-Kühnel A, Weinhold B. Sialylation is dispensable for early murine embryonic development in vitro. Chembiochem 2017; 18: 1305-1316

Angerer V, Schwenk P, Wallner T, Kaever V, Hiltbrunner A, Wilde A. The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2. Microbiology 2017; 163: 920-930

Bähre H, Kaever V. Identification and Quantification of Cyclic Di-Guanosine Monophosphate and Its Linear Metabolites by Reversed-Phase LC-MS/MS. Methods Mol Biol 2017; 1657:45-58

Bähre H, Kaever V. Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides. Handb Exp Pharmacol 2017; 238:293-306

Bähre H, Kaever V. Analytical Methods for the Quantification of Histamine and Histamine Metabolites. Handb Exp Pharmacol 2017; 241:3-19

Berrisch S, Ostermeyer J, Kaever V, Kälble S, Hilfiker-Kleiner D, Seifert R, Schneider EH. cUMP hydrolysis by PDE3A. Naunyn Schmiedebergs Arch Pharmacol 2017; 390: 269-280

Blötz C, Treffon K, Kaever V, Schwede F, Hammer E, Stülke J. Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae. Front Microbiol 2017; 8: 1328

Dessauer CW, Watts VJ2, Ostrom RS, Conti M, Dove S, Seifert R. International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev 2017; 69: 93-139

Doberenz S, Eckweiler D, Reichert O, Jensen V, Bunk B, Spröer C, Kordes A, Frangipani E, Luong K, Korlach J, Heeb S, Overmann J, Kaever V, Häussler S. Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles. MBio 2017; 8: e02312-16

Fazli M, Rybtke M, Steiner E, Weidel E, Berthelsen J, Groizeleau J, Bin W, Zhi BZ, Yaming Z, Kaever V, Givskov M, Hartmann RW, Eberl L, Tolker-Nielsen T. Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB. Microbiologyopen 2017; 6

Gundlach J, Herzberg C, Kaever V, Gunka K, Hoffmann T, Weiß M, Gibhardt J, Thürmer A, Hertel D, Daniel R, Bremer E, Commichau FM, Stülke J. Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis. Sci Signal 2017; 10: pii: eaal3011

Merfort I, Michel MC, Seifert R. Revised editorial guidelines for manuscripts on the pharmacology of plant extracts. Naunyn Schmiedebergs Arch Pharmacol 2017; 390: 765-766

Moreira RN, Dressaire C, Barahona S, Galego L, Kaever V, Jenal U, Arraiano CM.olA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation. MBio 2017; 8: e00443-17

Neumann D. Role of the Histamine H4-Receptor in Bronchial Asthma. Handb Exp Pharmacol 2017; 241:347-359

Paijo J, Kaever V, Kalinke U. cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry. Methods Mol Biol 2017; 1656: 153-166.

Reichert O, Fleming T, Neufang G, Schmelz M, Genth H,Kaever V, Wenck H, Staeb F, Terstegen L, Kolbe L, Roggenkamp D. Impaired Glyoxalase Activity is Associated with Reduced Expression of Neurotrophic Factors and Pro-inflammatory Processes in Diabetic Skin Cells. Exp Dermatol 2017; 26: 44-50

Sarenko O, Klauck G, Wilke FM, Pfiffer V, Richter AM, Herbst S, Kaever V, Hengge R. More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli. MBio. 2017; 8: e01639-17.

Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L.
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111. Microbiology 2017; 163: 754-764

Schneider EH. New perspectives for a well-known biogenic amine: mast cell-derived histamine as pathophysiological agent in vincristine-induced neuropathic pain. Naunyn Schmiedebergs Arch Pharmacol 2017; 390: 1085-1086.

Schneider EH, Seifert R. Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport.
Handb Exp Pharmacol 2017; 238:169-205

Schneider EH, Seifert R. Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutantsin the Sf9 Cell Expression System. Handb Exp Pharmacol 2017;241:63-118. 

Seifert R. cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Cell Functions. Handb Exp Pharmacol 2017; 238:3-23

Sprecher KS, Hug I, Nesper J, Potthoff E, Mahi MA, Sangermani M, Kaever V, Schwede T, Vorholt J, Jenal U. Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein. MBio 2017; 8: pii: e00294-17

Strasser A, Wittmann HJ, Seifert R. Binding Kinetics and Pathways of Ligands to GPCRs. Trends Pharmacol Sci. 2017; 38: 717-732

Wolter S, Dittmar F, Seifert R. cCMP and cUMP in Apoptosis: Concepts and Methods. Handb Exp Pharmacol 2017; 238: 25-47

Wunschel EJ, Schirmer B, Seifert R, Neumann D. Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice. Front Pharmacol 2017; 8: 642.

Zhang Y, Agrebi R, Bellows LE, Collet JF, Kaever V, Gründling A. Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3,5-cAMP in Bacteria. J Biol Chem 2017;  292: 313-327

 

2016 

Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M, Menon MB. GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Sci Rep 2016; 6: 20007.

Avsar M, Jansson K, Sommer W, Kruse B, Thissen S, Dreckmann K, Knoefel AK, Salman J, Hafer C, Hecker J, Buechler G, Karstens JH, Jonigk D, Länger F, Kaever V, Falk CS, Hewicker-Trautwein M, Ungefroren H, Haverich A, Strüber M, Warnecke G. Augmentation of Transient Donor Cell Chimerism and Alloantigen-Specific Regulation of Lung Transplants in Miniature Swine. Am J Transplant 2016; 16: 1371-82

Bæk KT, Bowman L, Millership C, Dupont Søgaard M, Kaever V, Siljamäki P, Savijoki K, Varmanen P, Nyman TA, Gründling A, Frees D. The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone. MBio 2016; 7: e01228-16.

Bowman L, Zeden MS, Schuster CF, Kaever V, Grundling A. New Insights into the Cyclic di-Adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic-Dinucleotide for Acid Stress Resistance in Staphylococcus aureus. J Biol Chem 2016; 291: 26970-26986

Dittmar F, Wolter S, Seifert R. Regulation of apoptosis by cyclic nucleotides in human erythroleukemia (HEL) cells and human myelogenous leukemia (K-562) cells. Biochem Pharmacol 2016; 112: 13-23.

Gaupels F, Furch AC, Zimmermann MR, Chen F, Kaever V, Buhtz A, Kehr J, Sarioglu H, Kogel KH, Durner J. Systemic Induction of NO-, Redox-, and cGMP Signaling in the Pumpkin Extrafascicular Phloem upon Local Leaf Wounding. Front Plant Sci 2016; 7: 154. Corrigendum: Front Plant Sci 2016; 7: 281.

Groizeleau J, Rybtke M, Andersen JB, Berthelsen J, Liu Y, Yang L, Nielsen TE, Kaever V, Givskov M, Tolker-Nielsen T. The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation. Microbiology 2016; 162: 1797-1807

Krol E, Klaner C, Gnau P, Kaever V, Essen LO, Becker A. Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti. Microbiology 2016; 162: 1840-1856

Lacanna E, Bigosch C, Kaever V, Boehm A, Becker A. Evidence for Escherichia coli diguanylate cyclase DgcZ interlinking surface sensing and adhesion via multiple regulatory routes. J Bacteriol 2016; 198: 2524-2535

Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U. cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells. PLoS Pathog 2016; 12: e1005546.

Pawar SV, Messina M, Rinaldo S, Cutruzzolà F, Kaever V, Rampioni G, Leoni L. Novel genetic tools to tackle c-di-GMP-dependent signaling in Pseudomonas aeruginosa. J Appl Microbiol 2016; 120: 205-217.

Reinartz MT, Wetzke M, Happle C, Kälble S, Scherer R, Kabesch M, Seifert R. Neutrophilic superoxide production can assess pharmacological and pharmacogenetic β-adrenoreceptor effects. Allergy 2016; 71: 1223-1227.

Rother S, Bartels M, Schweda AT, Resch K, Pallua N, Nourbakhsh M. NF-κB-repressing factor phosphorylation regulates transcription elongation via its interactions with 5'→3' exoribonuclease 2 and negative elongation factor. FASEB J 2016; 30: 174-185 

Schenk H, Neumann D, Kloth C. Histamine regulates murine primary dendritic cell functions. Immunopharmacol Immunotoxicol 2016; 38: 379-384

Schmidt A, Hammerbacher AS, Bastian M, Nieken KJ, Klockgether J, Merighi M, Lapouge K, Poschgan C, Kölle J, Acharya KR, Ulrich M, Tümmler B, Unden G, Kaever V, Lory S, Haas D, Schwarz S, Döring G. Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa. Environ Microbiol 2016; 18: 3390-3402

Schneider EH, Seifert R. The histamine H4-receptor and the central and peripheral nervous system: A critical analysis of the literature. Neuropharmacology 2016; 106:116-28. 

Seifert R. Distinct Signaling Roles of cIMP, cCMP, and cUMP.  Structure 2016; 24: 1627-1628

Seifert R. Does Vidarabine Mediate Cardioprotection via Inhibition of AC5? J Pharmacol Exp Ther 2016; 358: 242-243

Seifert R. Naunyn-Schmiedeberg's Archives of Pharmacology under new editorship: change and continuity. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 667-670.

Seifert R. Recent progress in the field of cIMP research. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 1045-1047.

Seifert R. Towards rational drug treatment of Lesch-Nyhan disease. Mol Genet Metab 2016; 118: 145-146.

Skotnicka D, Smaldone GT, Petters T, Trampari E, Liang J, Kaever V, Malone JG, Singer M, Søgaard-Andersen L. A minimal threshold of c-di-GMP is essential for fruiting body formation and sporulation in Myxococcus xanthus. PLoS Genet 2016; 12: e1006080.

Suppiger A, Eshwar AK, Stephan R, Kaever V, Eberl L, Lehner A. The DSF type quorum sensing signalling system RpfF/R regulates diverse phenotypes in the opportunistic pathogen Cronobacter. Sci Rep 2016; 6: 18753.

Tschirner SK, Bähre H, Kaever A, Schneider EH, Seifert R, Kaever V.
Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice. Life Sci 2016; 156: 68-73.

Tschirner SK, Gutzki F, Schneider EH, Seifert R, Kaever V. Neurotransmitter and their metabolite concentrations in different areas of the HPRT knockout mouse brain. J Neurol Sci 2016; 365: 169-174

Werner K, Neumann D, Seifert R. High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 87-101

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