Dissertationen, Master- und Bachelorarbeiten

Link zu den Dissertationen, Master- und Bachelorarbeiten des Instituts

Unsere Publikationen (2015-2020)


de Araujo LS, Pessler K, Sühs KW, Novoselova N, Klawonn F, Kuhn M, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F. Phosphatidylcholine PC ae C44:6 in cerebrospinal fluid is a sensitive biomarker for bacterial meningitis. J Transl Med 2020 18: 9.

Chaturvedi A, Goparaju R, Gupta C, Weder J, Klünemann T, Araujo Cruz MM, Kloos A, Goerlich K, Schottmann R, Othman B, Struys EA, Bähre H, Grote-Koska D, Brand K, Ganser A, Preller M, Heuser M. In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site. Leukemia 2020; 34: 416-426.

Costamagna D, Duelen R, Penna F, Neumann D, Costelli P, Sampaolesi M. Interleukin-4 administration improves muscle function, adult myogenesis, and lifespan of colon carcinoma-bearing mice. Cachexia Sarcopenia Muscle 2020; 11: 783-801.

Gibhardt J, Heidemann JL, Bremenkamp R, Rosenberg J, Seifert R, Kaever V, Ficner R, Commichau FM. An extracytoplasmic protein and a moonlighting enzyme modulate synthesis of c-di-AMP in Listeria monocytogenes. Environ Microbiol 2020; 22: 2771-2791

Janne G, Thöming JG, Tomasch J, Preusse M, Koska M, Grahl N, Pohl S, Willger SD, Kaever V, Müsken M, Häussler S. Parallel evolutionary paths to produce more than one Pseudomonas aeruginosa biofilm phenotype. NPJ Biofilms Microbiomes 2020; 6:2.

Latoscha A, Drexler DJ, Al-Bassam MM, Bandera AM, Kaever V, Findlay KC, Witte G, Tschowri N. c-di-AMP hydrolysis by the phosphodiesterase AtaC promotes differentiation of multicellular bacteria. Proc Natl Acad Sci U S A. 2020; 117:7392-7400

Schäfer H, Beckert B, Frese CK, Steinchen W, Nuss AM, Beckstette M, Hantke I, Driller K, Sudzinová P, Krásný L, Kaever V, Dersch P, Bange G, Wilson DN, Turgay K. The alarmones (p)ppGpp are part of the heat shock response of Bacillus subtilis. PLoS Genet 2020; 16: e1008275

Schimmel K, Jung M, Foinquinos A, San José G, Beaumont J, Bock K, Grote-Levi L, Xiao K, Bär C, Pfanne A, Just A, Zimmer K, Ngoy S, López B, Ravassa S, Samolovac S, Janssen-Peters H, Remke J, Scherf K, Dangwal S, Piccoli MT, Kleemiss F, Kreutzer FP, Kenneweg F, Leonardy J, Hobuß L, Santer L, Do QT, Geffers R, Braesen JH, Schmitz J, Brandenberger C, Müller DN, Wilck N, Kaever V, Bähre H, Batkai S, Fiedler J, Alexander KM, Wertheim BM, Fisch S, Liao R, Diez J, González A, Thum T. Natural Compound Library Screening Identifies New Molecules for the Treatment of Cardiac Fibrosis and Diastolic Dysfunction. Circulation 2020; 141: 751-767.

Schirmer B. Cytokines. In: Nijkamp and Parnham's Principles of Immunopharmacology. Parnham, Michael J., Nijkamp, Frans P., Rossi, Adriano (Eds.). Springer International Publishing.

Schirmer B, Lindemann L, Bittkau KS, Isaev R, Bösche D, Juchem M, Seifert R, Neumann D. Mouse Colonic Epithelial cells functionally express the histamine H4 receptor. J Pharmacol Exp Ther 2020; 373:167-174.

Schirmer B, Rother T, Bruesch I, Bleich A, Werlein C, Jonigk D, Seifert R, Neumann D. Genetic Deficiency of the Histamine H4-Receptor Reduces Experimental Colorectal Carcinogenesis in Mice. Cancers (Basel) 2020; 12: pii: E912.

Schneider EH, Hofmeister O, Kälble S, Seifert R. Apoptotic and anti-proliferative effect of guanosine and guanosine derivatives in HuT-78 T lymphoma cells. Naunyn Schmiedebergs Arch Pharmacol 2020; 393: 1251-1267

Seifert R, Schirmer B. A Simple Mechanistic Terminology of Psychoactive Drugs: A Proposal. Naunyn Schmiedebergs Arch Pharmacol 2020; 393: 1331-1339

Thibeaux R, Soupé-Gilbert ME, Kainiu M, Girault D, Bierque E, Fernandes J, Bähre H, Douyère A, Eskenazi N, Vinh J, Picardeau M, Goarant C. The Zoonotic Pathogen Leptospira Interrogans Mitigates Environmental Stress Through cyclic-di-GMP-controlled Biofilm Production. NPJ Biofilms Microbiomes 2020; 6: 24.

Wallner T, Pedroza L, Voigt K, Kaever V, Wilde A. The cyanobacterial phytochrome 2 regulates the expression of motility-related genes through the second messenger cyclic di-GMP. Photochem Photobiol Sci 2020; 11:783-801 



Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C6, Davies JA; CGTP Collaborators (Beuve A, Boison D, Brouckaert P, Burnett JC, Burns K, Dessauer C, Friebe A, Garthwaite J, Gertsch J, Helsby N, Izzo AA, Koesling D, Kuhn M, Ostrom R, Papapetropoulos A, Potter LR, Pyne NJ, Pyne S, Russwurm M, Schmidt HH, Seifert R, Stasch JP, Szabo C, van der Stelt M, van der Vliet A, Watts V.) THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Enzymes. Br J Pharmacol 2019; 176: S297-S396.

Braun F, Thomalla L, van der Does C, Quax TEF, Allers T, Kaever V, Albers SV. Cyclic nucleotides in archaea: Cyclic di-AMP in the archaeon Haloferax volcanii and its putative role. Microbiologyopen 2019; e829.

Chen F, Lukat P, Iqbal AA, Saile K, Kaever V, van den Heuvel J, Blankenfeldt W, Büssow K, Pessler F. Crystal structure of cis-aconitate decarboxylase reveals the impact of naturally occurring human mutations on itaconate synthesis. Proc Natl Acad Sci U S A 2019; 116: 20644-20654

Grobe S, Doberenz S, Ferreira K, Krueger J, Brönstrup M, Kaever V, Häußler S. Identification and quantification of (t)RNA modifications in Pseudomonas aeruginosa by liquid chromatography-tandem mass spectrometry. Chembiochem 2019; 20: 1430-1437.

Koppenhöfer S, Wang H, Scharfe M, Kaever V, Wagner-Döbler I, Tomasch J. Integrated Transcriptional Regulatory Network of Quorum Sensing, Replication Control, and SOS Response in Dinoroseobacter shibae. Front Microbiol 2019; 10: 803.

Kordes A, Grahl N, Koska M, Preusse M, Arce-Rodriguez A, Abraham WR, Kaever V, Häussler S. Establishment of an induced memory response in Pseudomonas aeruginosa during infection of a eukaryotic host. ISME J 2019; 13: 2018-2030.

Kuhla B, Kaever V, Tuchscherer A, Kuhla A. Involvement of plasma endocannabinoids and the hypothalamic endocannabinoid system in increasing feed intake after parturition of dairy cows. Neuroendocrinology 2019 [Epub ahead of print]

Li F, Cimdins A, Rohde M, Jänsch L, Kaever V, Nimtz M, Römling U. DncV Synthesizes Cyclic GMP-AMP and Regulates Biofilm Formation and Motility in Escherichia coli ECOR31. MBio 2019; 10: pii: e02492-18.

Melzer C, Rehn V, Yang Y, Bähre H, von der Ohe J, Hass R. Taxol-Loaded MSC-Derived Exosomes Provide a Therapeutic Vehicle to Target Metastatic Breast Cancer and Other Carcinoma Cells. Cancers (Basel). 2019; 11: pii: E798.

Nicholls TJ, Spåhr H, Jiang S, Siira SJ, Koolmeister C, Sharma S, Kauppila JHK, Jiang M, Kaever V, Rackham O, Chabes A, Falkenberg M, Filipovska A, Larsson NG, Gustafsson CM. Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria. Mol Cell 2019; 76: 784-796

Perduns R, Volk J, Plum M, Gutzki F, Kaever V, Geurtsen W. Effects of HEMA on Nrf2-related gene expression using a newly developed 3D co-culture model of the oral mucosa. Dent Mater 2019; pii: S0109-5641.

Ratuszny D, Sühs KW, Novoselova N, Kuhn M, Kaever V, Skripuletz T, Pessler F, Stangel M. Identification of Cerebrospinal Fluid Metabolites as Biomarkers for Enterovirus Meningitis. Int J Mol Sci 2019; 20: pii: E337.

Rossmann FM, Rick T, Mrusek D, Sprankel L, Dörrich AK, Leonhard T, Bubendorfer S, Kaever V, Bange G, Thormann KM. The GGDEF domain of the phosphodiesterase PdeB in Shewanella putrefaciens mediates recruitment by the polar landmark protein HubP. J Bacteriol 2019; pii: JB.00534-18.

Sayner SL, Choi CS, Maulucci ME, Ramila, KC, Zhou C, Scruggs AK, Yarbrough T, Blair LAH, King JAC, Seifert R, Kaever V, Bauer NN. Extracellular vesicles: another compartment for the second messenger, cyclic adenosine monophosphate (cAMP). Am J Physiol Lung Cell Mol Physiol 2019; 316: L691-L700.

Schwabe U, Seifert R. Parkinsonmittelhandlung der multiplen Sklerose. In: Arzneiverordnungsreport 2019; Hrsg. Schwabe U, Paffrath, D, Ludwig WD, Klauber J; Springer-Verlag Deutschland.

Scharrenbroich J, Kaever V, Dove S, Seifert R, Schneider EH. Hydrolysis of the non-canonical cyclic nucleotide cUMP by PDE9A: kinetics and binding mode. Naunyn Schmiedebergs Arch Pharmacol 2019; 392: 199-208.

Schirmer B, Giehl K, Kubatzky KF. Report of the Signal Transduction Society Meeting 2018-Signaling: From Past to Future. Int J Mol Sci. 2019; 20: pii: E227.

Schneider EH. Microglial histamine H4R in the pathophysiology of Parkinson's disease-a new actor on the stage? Naunyn Schmiedebergs Arch Pharmacol; 392: 641-645

Seifert R. Basic Knowledge of Pharmacology. Springer International Publishing, 492 Seiten

Seifert R, Günther J, Berlit P. Pharmakologische Behandlung der multiplen Sklerose. In: Arzneiverordnungsreport 2019; Hrsg. Schwabe U, Paffrath, D, Ludwig WD, Klauber J; Springer-Verlag Deutschland.

Sperling L, Mulero Alegría MD, Kaever V, Curtis PD. Analysis of Brevundimonas subvibrioides developmental signaling systems reveals inconsistencies between phenotypes and c-di-GMP levels. J Bacteriol 2019; pii: JB.00447-19

Sühs KW, Novoselova N, Kuhn M, Seegers L, Kaever V, Müller-Vahl K, Trebst C, Skripuletz T, Stangel M, Pessler F. Kynurenine is a cerebrospinal fluid biomarker for bacterial and viral CNS infections. J Infect Dis 2019; 220: 127-138.

Wissig J, Grischin J, Bassler J, Schubert C, Friedrich T, Bähre H, Schultz JE, Unden G. CyaC, a redox-regulated adenylate cyclase of Sinorhizobium meliloti with a quinone responsive diheme-B membrane anchor domain. Mol Microbiol 2019; 112: 16-28.



Kloth C, Schirmer B, Munder A, Stelzer T, Rothschuh J, Seifert R. The Role of Pseudomonas aeruginosa ExoY in an Acute Mouse Lung Infection Model. Toxins (Basel). 2018;10: pii: E185.

Kuhn M, Sühs KW, Akmatov MK, Klawonn F, Wang J, Skripuletz T, Kaever V, Stangel M, Pessler F. Mass-spectrometric profiling of cerebrospinal fluid reveals metabolite biomarkers for CNS involvement in varicella zoster virus reactivation. J Neuroinflammation 2018; 15: 20.

Müsken M, Pawar V, Schwebs T, Bähre H, Felgner S, Weiss S, Häussler S. Breaking the Vicious Cycle of Antibiotic Killing and Regrowth of Biofilm-Residing Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2018; 62: pii: e01635-18.

Munder A, Rothschuh J, Schirmer B, Klockgether J, Kaever V, Tümmler B, Seifert R, Kloth C. The Pseudomonas aeruginosa ExoY phenotype of high-copy-number recombinants is not detectable in natural isolates. Open Biol 2018; 8: pii: 170250.

Ostermeyer J, Golly F, Kaever V, Dove S, Seifert R, Schneider EH. cUMP hydrolysis by PDE3B. Naunyn Schmiedebergs Arch Pharmacol 2018; 391: 891-905

Schäper S, Yau HCL, Krol E, Skotnicka D, Heimerl T, Gray J, Kaever V, Søgaard-Andersen L, Vollmer W, Becker A. Seven-transmembrane receptor protein RgsP and cell wall-binding protein RgsM promote unipolar growth in Rhizobiales. PLoS Genet. 2018; 14: e1007594.

Schirmer B, Bringmann L, Seifert R, Neumann D. In vivo Evidence for Partial Activation of Eosinophils via the Histamine H4-Receptor: Adoptive Transfer Experiments Using Eosinophils From H4R-/- and H4R+/+ Mice. Front Immunol 2018; 9: 2119.

Schirmer B, Giehl K, Kubatzky KF. Report of the Signal Transduction Society Meeting 2017—Metabolism in Health and Disease. Int J Mol Sci 2018; 19: 549

Seifert R. Basiswissen Pharmakologie. 494 Seiten. Springer, Berlin, Heidelberg

Seifert R. Rethinking Pharmacological Nomenclature. Trends Pharmacol Sci 2018; 39: 785-797

Seifert R. Act Immediately Upon Onset of Symptoms. Dtsch Arztebl Int. 2018; 115: 748.

Zhang Y, Sass A, Van Acker H, Wille J, Verhasselt B, Van Nieuwerburgh F, Kaever V, Crabbé A, Coenye T. Coumarin Reduces Virulence and Biofilm Formation in Pseudomonas aeruginosa by Affecting Quorum Sensing, Type III Secretion and C-di-GMP Levels. Front Microbiol. 2018; 9:1952.



Abeln M, Borst KM, Cajic S, Thiesler H, Kats E, Albers I, Kuhn M, Kaever V, Rapp E, Münster-Kühnel A, Weinhold B. Sialylation is dispensable for early murine embryonic development in vitro. Chembiochem 2017; 18: 1305-1316

Angerer V, Schwenk P, Wallner T, Kaever V, Hiltbrunner A, Wilde A. The protein Slr1143 is an active diguanylate cyclase in Synechocystis sp. PCC 6803 and interacts with the photoreceptor Cph2. Microbiology 2017; 163: 920-930

Bähre H, Kaever V. Identification and Quantification of Cyclic Di-Guanosine Monophosphate and Its Linear Metabolites by Reversed-Phase LC-MS/MS. Methods Mol Biol 2017; 1657:45-58

Bähre H, Kaever V. Mass Spectrometric Analysis of Non-canonical Cyclic Nucleotides. Handb Exp Pharmacol 2017; 238:293-306

Bähre H, Kaever V. Analytical Methods for the Quantification of Histamine and Histamine Metabolites. Handb Exp Pharmacol 2017; 241:3-19

Berrisch S, Ostermeyer J, Kaever V, Kälble S, Hilfiker-Kleiner D, Seifert R, Schneider EH. cUMP hydrolysis by PDE3A. Naunyn Schmiedebergs Arch Pharmacol 2017; 390: 269-280

Blötz C, Treffon K, Kaever V, Schwede F, Hammer E, Stülke J. Identification of the Components Involved in Cyclic Di-AMP Signaling in Mycoplasma pneumoniae. Front Microbiol 2017; 8: 1328

Dessauer CW, Watts VJ2, Ostrom RS, Conti M, Dove S, Seifert R. International Union of Basic and Clinical Pharmacology. CI. Structures and Small Molecule Modulators of Mammalian Adenylyl Cyclases. Pharmacol Rev 2017; 69: 93-139

Doberenz S, Eckweiler D, Reichert O, Jensen V, Bunk B, Spröer C, Kordes A, Frangipani E, Luong K, Korlach J, Heeb S, Overmann J, Kaever V, Häussler S. Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles. MBio 2017; 8: e02312-16

Fazli M, Rybtke M, Steiner E, Weidel E, Berthelsen J, Groizeleau J, Bin W, Zhi BZ, Yaming Z, Kaever V, Givskov M, Hartmann RW, Eberl L, Tolker-Nielsen T. Regulation of Burkholderia cenocepacia biofilm formation by RpoN and the c-di-GMP effector BerB. Microbiologyopen 2017; 6

Gundlach J, Herzberg C, Kaever V, Gunka K, Hoffmann T, Weiß M, Gibhardt J, Thürmer A, Hertel D, Daniel R, Bremer E, Commichau FM, Stülke J. Control of potassium homeostasis is an essential function of the second messenger cyclic di-AMP in Bacillus subtilis. Sci Signal 2017; 10: pii: eaal3011

Merfort I, Michel MC, Seifert R. Revised editorial guidelines for manuscripts on the pharmacology of plant extracts. Naunyn Schmiedebergs Arch Pharmacol 2017; 390: 765-766

Moreira RN, Dressaire C, Barahona S, Galego L, Kaever V, Jenal U, Arraiano CM.olA Is Required for the Accurate Regulation of c-di-GMP, a Central Player in Biofilm Formation. MBio 2017; 8: e00443-17

Neumann D. Role of the Histamine H4-Receptor in Bronchial Asthma. Handb Exp Pharmacol 2017; 241:347-359

Paijo J, Kaever V, Kalinke U. cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry. Methods Mol Biol 2017; 1656: 153-166.

Reichert O, Fleming T, Neufang G, Schmelz M, Genth H,Kaever V, Wenck H, Staeb F, Terstegen L, Kolbe L, Roggenkamp D. Impaired Glyoxalase Activity is Associated with Reduced Expression of Neurotrophic Factors and Pro-inflammatory Processes in Diabetic Skin Cells. Exp Dermatol 2017; 26: 44-50

Sarenko O, Klauck G, Wilke FM, Pfiffer V, Richter AM, Herbst S, Kaever V, Hengge R. More than Enzymes That Make or Break Cyclic Di-GMP-Local Signaling in the Interactome of GGDEF/EAL Domain Proteins of Escherichia coli. MBio. 2017; 8: e01639-17.

Schmid N, Suppiger A, Steiner E, Pessi G, Kaever V, Fazli M, Tolker-Nielsen T, Jenal U, Eberl L.
High intracellular c-di-GMP levels antagonize quorum sensing and virulence gene expression in Burkholderia cenocepacia H111. Microbiology 2017; 163: 754-764

Schneider EH. New perspectives for a well-known biogenic amine: mast cell-derived histamine as pathophysiological agent in vincristine-induced neuropathic pain. Naunyn Schmiedebergs Arch Pharmacol 2017; 390: 1085-1086.

Schneider EH, Seifert R. Inactivation of Non-canonical Cyclic Nucleotides: Hydrolysis and Transport.
Handb Exp Pharmacol 2017; 238:169-205

Schneider EH, Seifert R. Pharmacological Characterization of Human Histamine Receptors and Histamine Receptor Mutantsin the Sf9 Cell Expression System. Handb Exp Pharmacol 2017;241:63-118. 

Seifert R. cCMP and cUMP Across the Tree of Life: From cCMP and cUMP Generators to cCMP- and cUMP-Regulated Cell Functions. Handb Exp Pharmacol 2017; 238:3-23

Sprecher KS, Hug I, Nesper J, Potthoff E, Mahi MA, Sangermani M, Kaever V, Schwede T, Vorholt J, Jenal U. Cohesive Properties of the Caulobacter crescentus Holdfast Adhesin Are Regulated by a Novel c-di-GMP Effector Protein. MBio 2017; 8: pii: e00294-17

Strasser A, Wittmann HJ, Seifert R. Binding Kinetics and Pathways of Ligands to GPCRs. Trends Pharmacol Sci. 2017; 38: 717-732

Wolter S, Dittmar F, Seifert R. cCMP and cUMP in Apoptosis: Concepts and Methods. Handb Exp Pharmacol 2017; 238: 25-47

Wunschel EJ, Schirmer B, Seifert R, Neumann D. Lack of Histamine H4-Receptor Expression Aggravates TNBS-Induced Acute Colitis Symptoms in Mice. Front Pharmacol 2017; 8: 642.

Zhang Y, Agrebi R, Bellows LE, Collet JF, Kaever V, Gründling A. Evolutionary Adaptation of the Essential tRNA Methyltransferase TrmD to the Signaling Molecule 3,5-cAMP in Bacteria. J Biol Chem 2017;  292: 313-327



Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M, Menon MB. GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Sci Rep 2016; 6: 20007.

Avsar M, Jansson K, Sommer W, Kruse B, Thissen S, Dreckmann K, Knoefel AK, Salman J, Hafer C, Hecker J, Buechler G, Karstens JH, Jonigk D, Länger F, Kaever V, Falk CS, Hewicker-Trautwein M, Ungefroren H, Haverich A, Strüber M, Warnecke G. Augmentation of Transient Donor Cell Chimerism and Alloantigen-Specific Regulation of Lung Transplants in Miniature Swine. Am J Transplant 2016; 16: 1371-82

Bæk KT, Bowman L, Millership C, Dupont Søgaard M, Kaever V, Siljamäki P, Savijoki K, Varmanen P, Nyman TA, Gründling A, Frees D. The Cell Wall Polymer Lipoteichoic Acid Becomes Nonessential in Staphylococcus aureus Cells Lacking the ClpX Chaperone. MBio 2016; 7: e01228-16.

Bowman L, Zeden MS, Schuster CF, Kaever V, Grundling A. New Insights into the Cyclic di-Adenosine Monophosphate (c-di-AMP) Degradation Pathway and the Requirement of the Cyclic-Dinucleotide for Acid Stress Resistance in Staphylococcus aureus. J Biol Chem 2016; 291: 26970-26986

Dittmar F, Wolter S, Seifert R. Regulation of apoptosis by cyclic nucleotides in human erythroleukemia (HEL) cells and human myelogenous leukemia (K-562) cells. Biochem Pharmacol 2016; 112: 13-23.

Gaupels F, Furch AC, Zimmermann MR, Chen F, Kaever V, Buhtz A, Kehr J, Sarioglu H, Kogel KH, Durner J. Systemic Induction of NO-, Redox-, and cGMP Signaling in the Pumpkin Extrafascicular Phloem upon Local Leaf Wounding. Front Plant Sci 2016; 7: 154. Corrigendum: Front Plant Sci 2016; 7: 281.

Groizeleau J, Rybtke M, Andersen JB, Berthelsen J, Liu Y, Yang L, Nielsen TE, Kaever V, Givskov M, Tolker-Nielsen T. The anti-cancerous drug doxorubicin decreases the c-di-GMP content in Pseudomonas aeruginosa but promotes biofilm formation. Microbiology 2016; 162: 1797-1807

Krol E, Klaner C, Gnau P, Kaever V, Essen LO, Becker A. Cyclic mononucleotide- and Clr-dependent gene regulation in Sinorhizobium meliloti. Microbiology 2016; 162: 1840-1856

Lacanna E, Bigosch C, Kaever V, Boehm A, Becker A. Evidence for Escherichia coli diguanylate cyclase DgcZ interlinking surface sensing and adhesion via multiple regulatory routes. J Bacteriol 2016; 198: 2524-2535

Paijo J, Döring M, Spanier J, Grabski E, Nooruzzaman M, Schmidt T, Witte G, Messerle M, Hornung V, Kaever V, Kalinke U. cGAS Senses Human Cytomegalovirus and Induces Type I Interferon Responses in Human Monocyte-Derived Cells. PLoS Pathog 2016; 12: e1005546.

Pawar SV, Messina M, Rinaldo S, Cutruzzolà F, Kaever V, Rampioni G, Leoni L. Novel genetic tools to tackle c-di-GMP-dependent signaling in Pseudomonas aeruginosa. J Appl Microbiol 2016; 120: 205-217.

Reinartz MT, Wetzke M, Happle C, Kälble S, Scherer R, Kabesch M, Seifert R. Neutrophilic superoxide production can assess pharmacological and pharmacogenetic β-adrenoreceptor effects. Allergy 2016; 71: 1223-1227.

Rother S, Bartels M, Schweda AT, Resch K, Pallua N, Nourbakhsh M. NF-κB-repressing factor phosphorylation regulates transcription elongation via its interactions with 5'→3' exoribonuclease 2 and negative elongation factor. FASEB J 2016; 30: 174-185 

Schenk H, Neumann D, Kloth C. Histamine regulates murine primary dendritic cell functions. Immunopharmacol Immunotoxicol 2016; 38: 379-384

Schmidt A, Hammerbacher AS, Bastian M, Nieken KJ, Klockgether J, Merighi M, Lapouge K, Poschgan C, Kölle J, Acharya KR, Ulrich M, Tümmler B, Unden G, Kaever V, Lory S, Haas D, Schwarz S, Döring G. Oxygen-dependent regulation of c-di-GMP synthesis by SadC controls alginate production in Pseudomonas aeruginosa. Environ Microbiol 2016; 18: 3390-3402

Schneider EH, Seifert R. The histamine H4-receptor and the central and peripheral nervous system: A critical analysis of the literature. Neuropharmacology 2016; 106:116-28. 

Seifert R. Distinct Signaling Roles of cIMP, cCMP, and cUMP.  Structure 2016; 24: 1627-1628

Seifert R. Does Vidarabine Mediate Cardioprotection via Inhibition of AC5? J Pharmacol Exp Ther 2016; 358: 242-243

Seifert R. Naunyn-Schmiedeberg's Archives of Pharmacology under new editorship: change and continuity. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 667-670.

Seifert R. Recent progress in the field of cIMP research. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 1045-1047.

Seifert R. Towards rational drug treatment of Lesch-Nyhan disease. Mol Genet Metab 2016; 118: 145-146.

Skotnicka D, Smaldone GT, Petters T, Trampari E, Liang J, Kaever V, Malone JG, Singer M, Søgaard-Andersen L. A minimal threshold of c-di-GMP is essential for fruiting body formation and sporulation in Myxococcus xanthus. PLoS Genet 2016; 12: e1006080.

Suppiger A, Eshwar AK, Stephan R, Kaever V, Eberl L, Lehner A. The DSF type quorum sensing signalling system RpfF/R regulates diverse phenotypes in the opportunistic pathogen Cronobacter. Sci Rep 2016; 6: 18753.

Tschirner SK, Bähre H, Kaever A, Schneider EH, Seifert R, Kaever V.
Non-targeted metabolomics by high resolution mass spectrometry in HPRT knockout mice. Life Sci 2016; 156: 68-73.

Tschirner SK, Gutzki F, Schneider EH, Seifert R, Kaever V. Neurotransmitter and their metabolite concentrations in different areas of the HPRT knockout mouse brain. J Neurol Sci 2016; 365: 169-174

Werner K, Neumann D, Seifert R. High constitutive Akt2 activity in U937 promonocytes: effective reduction of Akt2 phosphorylation by the histamine H2-receptor and the β2-adrenergic receptor. Naunyn Schmiedebergs Arch Pharmacol 2016; 389: 87-101



Bähre H, Hartwig C, Munder A, Wolter S, Stelzer T, Schirmer B, Beckert U, Frank DW, Tümmler B, Kaever V, Seifert R. cCMP and cUMP occur in vivo. Biochem Biophys Res Commun 2015; 460: 909-914

Beermann S, Bernhardt G, Seifert R, Buschauer A, Neumann D. Histamine H1- and H4-receptor signaling cooperatively regulate MAPK activation. Biochem Pharmacol 2015; 98: 432-439

Berod L, Friedrich C, Nandan A, Freitag J, Hagemann S, Harmrolfs K, Sandouk A, Hesse C, Castro CN, Bähre H, Tschirner SK, Gorinski N, Gohmert M, Mayer CT, Huehn J, Ponimaskin E, Abraham WR, Müller R, Lochner M, Sparwasser T. Erratum: De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells. Nat Med 2015; 21: 414

Beyer C, Zenzmaier C, Palumbo-Zerr K, Mancuso R, Distler A, Dees C, Zerr P, Huang J, Maier C, Pachowsky ML, Friebe A, Sandner P, Distler O, Schett G, Berger P, Distler JH. Stimulation of the soluble guanylate cyclase (sGC) inhibits fibrosis by blocking non-canonical TGFβ signalling. Ann Rheum Dis 2015; 74: 1408-1416

Blanka A, Düvel J, Dötsch A, Klinkert B, Abraham WR, Kaever V, Ritter C, Narberhaus F, Häussler S. Constitutive production of c-di-GMP is associated with mutations in a variant of Pseudomonas aeruginosa with altered membrane composition. Sci Signal 2015; 8 (372): ra36

Bridgeman A, Maelfait J, Davenne T, Partridge T, Peng Y, Mayer A, Dong T, Kaever V, Borrow P, Rehwinkel J. Viruses transfer the antiviral second messenger cGAMP between cells. Science 2015; 349: 1228-1232

Cohen D, Mechold U, Nevenzal H, Yarmiyhu Y, Randall TE, Bay DC, Rich JD, Parsek MR, Kaever V, Harrison JJ, Banin E. Oligoribonuclease is a central feature of cyclic diguanylate signaling in Pseudomonas aeruginosa. Proc Natl Acad Sci USA 2015; 112: 11359-11364

Corrigan RM, Bowman L, Willis AR, Kaever V, Gründling A. Cross-talk between Two Nucleotide-signaling Pathways in Staphylococcus aureus. J Biol Chem 2015; 290: 5826-5839

Dees C, Beyer C, Distler A, Soare A, Zhang Y, Palumbo-Zerr K, Distler O, Schett G, Sandner P, Distler JH. Stimulators of soluble guanylate cyclase (sGC) inhibit experimental skin fibrosis of different aetiologies. Ann Rheum Dis 2015; 74: 1621-1625

Dittmar F, Abdelilah-Seyfried S, Tschirner SK, Kaever V, Seifert R. Temporal and organ-specific detection of cNMPs including cUMP in the zebrafish. Biochem Biophys Res Commun 2015; 468:708-712

Friebe A, Sandner P, Seifert R. From bedside to bench - Meeting report of the 7th International Conference on cGMP "cGMP: generators, effectors and therapeutic implications" in Trier, Germany, from June 19th to 21st 2015. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 1237-1246

Füllhase C, Hennenberg M, Sandner P, Strittmatter F, Niedworok C, Bauer RM, Gratzke C, Soler R, Stief C, Andersson KE. Reduction of obstruction related bladder overactivity by the guanylyl cyclase modulators BAY 41-2272 and BAY 60-2770 alone or in combination with a phosphodiesterase type 5 inhibitor. Neurourol Urodyn 2015; 34: 787-793

Goy SD, Olling A, Neumann D, Pich A, Gerhard R. Human neutrophils are activated by a peptide fragment of Clostridium difficile Toxin B presumably via formyl peptide receptor. Cell Microbiol 2015; 17: 893-909

Gundlach J, Dickmanns A, Schröder-Tittmann K, Neumann P, Kaesler J, Kampf J, Herzberg C, Hammer E, Schwede F, Kaever V, Tittmann K, Stülke J, Ficner R. Identification, characterization and structure analysis of the c-di-AMP binding PII-like signal transduction protein DarA. J Biol Chem 2015; 290: 3069-3080 

Hartwig C, Munder A, Glage S, Wedekind D, Schenk H, Seifert R, Neumann D. The histamine H4-receptor (H4R) regulates eosinophilic inflammation in ovalbumin-induced experimental allergic asthma in mice. Eur J Immunol 2015; 45: 1129-1140

Heifetz A, Schertler GF, Seifert R, Tate CG, Sexton PM, Gurevich VV, Fourmy D, Cherezov V, Marshall FH, Storer RI, Moraes I, Tikhonova IG, Tautermann CS, Hunt P, Ceska T, Hodgson S, Bodkin MJ, Singh S, Law RJ, Biggin PC. GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 883-903  

Kagermeier N, Werner K, Keller M, Baumeister P, Bernhardt G, Seifert R, Buschauer A. Dimeric carbamoylguanidine-type histamine H2 receptor ligands: A new class of potent and selective agonists. Bioorg Med Chem 2015; pii: S0968-0896(15)00015-2

Lachmann N, Czarnecki K, Brennig S, Phaltane R, Heise M, Heinz N, Kempf H, Dilloo D, Kaever V, Schambach A, Heuser M, Moritz T. Deoxycytidine-kinase (dCK) knock-down as a novel myeloprotective strategy in the context of fludarabine, cytarabine, or cladribine therapy. Leukemia 2015; 29: 2266-2269 

Littmann T, Göttle M, Reinartz MT, Kälble S, Wainer IW, Ozawa T, Seifert R. Recruitment of β-Arrestin 1 and 2 to the β2-Adrenoceptor: Analysis of 65 Ligands. J Pharmacol Exp Ther 2015; 355: 183-190

Lübker C, Dove S, Tang WJ, Urbauer RJ, Moskovitz J, Urbauer JL, Seifert R. Different Roles of N-Terminal and C-Terminal Domains in Calmodulin for Activation of Bacillus anthracis Edema Factor. Toxins (Basel) 2015; 7: 2598-2614

Lübker C, Seifert R. Effects of 39 Compounds on Calmodulin-Regulated Adenylyl Cyclases AC1 and Bacillus anthracis Edema Factor. PLoS One 2015; 10: e0124017

Lübker C, Urbauer RJ, Moskovitz J, Dove S, Weisemann J, Fedorova M, Urbauer JL, Seifert R. Membranous adenylyl cyclase 1 activation is regulated by oxidation of N- and C-terminal methionine residues in calmodulin. Biochem Pharmacol 2015; 93: 196-209

Michel MC, Seifert R. Selectivity of pharmacological tools: implications for use in cell physiology. A Review in the Theme: Cell Signaling: Proteins, Pathways and Mechanisms. Am J Physiol Cell Physiol 2015; 3087: C505-C520

Morrow KA, Seifert R, Kaever V, Britain AL, Sayner SL, Ochoa CD, Cioffi EA, Frank DW, Rich TC, Stevens T. Heterogeneity of Pulmonary Endothelial Cyclic Nucleotide Response to Pseudomonas aeruginosa ExoY Infection. Am J Physiol Lung Cell Mol Physiol 2015; 309: L1199–L1207

Peltier J, Shaw HA, Couchman EC, Dawson LF, Yu L, Choudhary JS, Kaever V, Wren BW, Fairweather NF. Cyclic-di-GMP regulates production of sortase substrates of Clostridium difficile and their surface exposure through ZmpI protease-mediated cleavage. J Biol Chem 2015; 290: 24453-24469

Reichert O, Kolbe L, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G. UV Radiation Induces CXCL5 Expression in Human Skin. Exp Dermatol 2015; 24: 309-312

Reinartz MT, Kälble S, Littmann T, Ozawa T, Dove S, Kaever V, Wainer IW, Seifert R. Structure-bias relationships for fenoterol stereoisomers in six molecular and cellular assays at the β2-adrenoceptor. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 51-65

Reinartz MT, Kälble S, Wainer IW, Seifert R. Interaction of fenoterol stereoisomers with β2-adrenoceptor-G sα fusion proteins: antagonist and agonist competition binding. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 517-524

Ripperger T, Manukjan G, Meyer J, Wolter S, Schambach A, Bohne J, Modlich U, Li Z, Skawran B, Schlegelberger B, Steinemann D. The heteromeric transcription factor GABP activates the ITGAM/CD11b promoter and induces myeloid differentiation. Biochim Biophys Acta 2015;1849: 1145-1154

Rismondo J, Gibhardt J, Rosenberg J, Kaever V, Halbedel S, Commichau FM. Phenotypes associated with the essential diadenylate cyclase CdaA and its potential regulator CdaR in the human pathogen Listeria monocytogenes. J Bacteriol 2015; 198: 416-426

Rosenberg J, Dickmanns A, Neumann P, Gunka K, Arens J, Kaever V, Stulke J, Ficner R, Commichau FM. Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes. J Biol Chem 2015; 290: 6596-6606

Sandner P, Tinel H, Affaitati G, Costantini R, Giamberardino MA. Effects of PDE5 Inhibitors and sGC Stimulators in a Rat Model of Artificial Ureteral Calculosis. PLoS One 2015; 10: e0141477

Schäper S, Krol E, Skotnicka D, Kaever V, Hilker R, Søgaard-Andersen L, Becker A. Cyclic di-GMP regulates multiple cellular functions in the symbiotic α-proteobacterium Sinorhizobium meliloti. J Bacteriol 2015; 198: 521-35

Schirmer B, Rezniczek T, Seifert R, Neumann D. Proinflammatory role of the histamine H4 receptor in dextrane sodium sulfate-induced acute colitis. Biochem Pharmacol 2015; 98: 102-109

Schirmer B, Wedekind D, Glage S, Neumann D. Deletion of IL-18 Expression Ameliorates Spontaneous Kidney Failure in MRLlpr Mice. PLoS One 2015; 10: e0140173

Schneider EH, Neumann D, Seifert R. Histamine H4-receptor expression in the brain? Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 5-9

Schneider EH, Seifert R. Report on the Third Symposium "cCMP and cUMP as New Second Messengers". Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 1-3

Seifert R. Adrenaline as the medication of choice. Dtsch Arztebl Int. 2015; 112: 59

Seifert R. cCMP and cUMP: emerging second messengers. Trends Biochem Sci 2015; 40: 8-15

Seifert R. Emerging Role of Phosphodiesterase 2A in Hypertension. Hypertension 2015; 66: 13-14

Seifert R. How do basic secretagogues activate mast cells? Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 279-281

Seifert R, Schneider EH, Bähre H. From canonical to non-canonical cyclic nucleotides as second messengers: Pharmacological implications. Pharmacol Ther 2015; 148C: 154-184

Skotnicka D, Petters T, Heering J, Hoppert M, Kaever V, Søgaard-Andersen L. c-di-GMP regulates type IV pili-dependent-motility in Myxococcus xanthus. J Bacteriol 2015; 198: 77-90

Strasser A, Wittmann HJ, Schneider EH, Seifert R. Modulation of GPCRs by monovalent cations and anions. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 363-380

Tschernig T, Hartwig C, Jeron A, Dinh QT, Gereke M, Bruder D. First genomic analysis of dendritic cells from lung and draining lymph nodes in murine asthma. Int J Genomics 2015; 2015: 638032

Tschirner SK, Gutzki F, Kaever V, Seifert R, Schneider EH. Altered histamine neurotransmission in HPRT-deficient mice. Neurosci Lett. 2015; 609:74-80

Visaggio D, Pasqua M, Bonchi C, Kaever V, Visca P, Imperi F. Cell aggregation promotes pyoverdine-dependent iron uptake and virulence in Pseudomonas aeruginosa. Front Microbiol 2015; 6: 902

Werner K, Kälble S, Wolter S, Schneider EH, Buschauer A, Neumann D, Seifert R. Flow cytometric analysis with a fluorescently labeled formyl peptide receptor ligand as a new method to study the pharmacological profile of the histamine H2 receptor. Naunyn Schmiedebergs Arch Pharmacol 2015; 388: 1039-1052

Wifling D, Löffel K, Nordemann U, Strasser A, Bernhardt G, Dove S, Seifert R, Buschauer A. Molecular determinants for the high constitutive activity of the human histamine H4 receptor: Functional studies on orthologs and mutants. Br J Pharmacol 2015; 172: 785-798

Wolter S, Kloth C, Golombek M, Dittmar F, Försterling L, Seifert R. cCMP causes caspase-dependent apoptosis in mouse lymphoma cell lines. Biochem Pharmacol 2015;98: 119-131

Yang Y, Bucan V, Baehre H, von der Ohe J, Otte A, Hass R. Acquisition of new tumor cell properties by MSC-derived exosomes. Int J Oncol 2015; 244-252

Zenzmaier C, Kern J, Heitz M, Plas E, Zwerschke W, Mattesich M, Sandner P, Berger P. Activators and stimulators of soluble guanylate cyclase counteract myofibroblast differentiation of prostatic and dermal stromal cells. Exp Cell Res 2015: 338: 162-169.

Zwadlo C, Schmidtmann E, Szaroszyk M, Kattih B, Froese N, Hinz H, Schmitto JD, Widder J, Batkai S, Bähre H, Kaever V, Thum T, Bauersachs J, Heineke J. Anti-Androgenic Therapy with Finasteride Attenuates Cardiac Hypertrophy and Left Ventricular Dysfunction. Circulation 2015; 131: 1071-81


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