Remodeling in the Alveolar Region of the Mouse Lung Spermidine supplementation and voluntary activity differentially affect obesity-related structural changes in the mouse lung Dietary Carbohydrates and Fat [...] acute lung injury-induced changes of the air-blood barrier, lung function, and inflammation in the mouse The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury Aging impairs alveolar epithelial [...] type II cell function in acute lung injury Age-Related Structural and Functional Changes in the Mouse Lung Nutrition and Cardiopulmonary Health Projektverantwortliche: PD Dr. rer. nat. Julia Schipke

Our research focuses on the genetic control mechanisms governing vertebrate development using the mouse as a model organism. More specifically, we are interested in gaining a better understanding of the [...] valvular-septal defects of the heart, anomalies of the urinary tract and hearing loss by establishing mouse models for these disorders and deciphering the molecular changes associated with them. In the long [...] techniques of modern cell and molecular biology in addition to embryological manipulations in the mouse as well as transgenics and targeted gene disruption to gain information on the mode of action of genes

regulates endothelial identity in mouse fetal arteries. Blood, 113, 5680-5688 Notch signalling in the paraxial mesoderm is most sensitive to reduced Pofut1 levels during early mouse development. (2009). Schus [...] 912-925 Kispert, A. and Gossler, A. (2004). Introduction into early mouse development. In Handbook of Experimental Animals: The Laboratory Mouse (H.J. Hedrich, ed.). Academic press Takahashi, Y., Inoue, T., [...] Gossler A. The highly conserved FOXJ1 target CFAP161 is dispensable for motile ciliary function in mouse and Xenopus . Sci Rep. 2021; 11: 13333. Published online 2021 Jun 25. doi: 10.1038/s41598-021-92495-3

characterization of individual genetic variation of UDP-glucuronosyltransferase regulation in a mouse model Final exam November 2009 Luis Guachalla Gutierrez BOLIVIA supervisor: Prof. Dr. Rudolph, now [...] Greten, Gastroenterology/Hepatology/ Endocrinology, OE 6810, project: T cell based therapies in a mouse model of colitis associated colon cancer Final exam November 2009 Harshvardhan Rolyan INDIA supervisor: [...] PD. Dr. Rudolph, now University of Ulm project: Production and characterisation of Est1 knockout mouse. Role of Rad9/Hus1 in senescence signalling Final exam June 2009 Kathrin Steinwede GERMANY supervisor:

n of liver grafts in a porcine model. Infrastructure: Primary Human Hepatocyte (MHH) / Humanized Mouse (UKE) Core Facility Infrastructure coordinator: Florian Vondran Located at Hannover Medical School [...] studies and long-term antiviral drug evaluation. Thus, the unit recently has merged with the Humanized Mouse Platform lead by Prof. M. Dandri at UKE to serve as a new competitive technological platform enabling [...] regeneration, we combine longitudinal imaging analysis in vivo through an abdominal imaging window in the mouse with simultaneous manipulation on a single cell level. In vivo imaging of organs via endoscopic, fiber

Cell. Mol. Life Sci. 69, 1377-1389. Kispert, A. and Gossler, A. (2012). Early mouse development. In: The Laboratory mouse, 2nd edition, Ed. by H. Hedrich. Academic Press, San Diego. Rudat, C., Kispert [...] compartments. Genes Dev. 18, 1209-1222. Kispert, A. and Gossler, A. (2004). Early mouse development. In: The Laboratory mouse. Ed. by H. Hedrich. Academic Press, San Diego. Haenig, B., and Kispert, A. (2004) [...] and expression analysis of the mouse T-box gene Tbx18 . Mech. Dev. 100, 83-86. Kraus, F., Haenig, B. and Kispert, A. (2001). Cloning and expression analysis of the mouse T-box gene Tbx20. Mech. Dev. 100

U, Kuhn C, Ismail I, Warnecke G, Shrestha ML, Cebotari S, Haverich A. Cardiopulmonary bypass in a mouse model: A novel approach. J Vis Exp. 2017;(127). https://www.ncbi.nlm.nih.gov/pubmed/28994765 Napp [...] Mapping for Noninvasive Assessment of Interstitial Edema in Acute Cardiac Allograft Rejection in a Mouse Model of Heterotopic Heart Transplantation. Invest Radiol. 2017; 53:271-277. www.ncbi.nlm.nih.gov

development, homeostasis and regeneration of the mesenchymal and epithelial tissue compartments of the mouse ureter. We wish to explore how different signaling pathways (such as Notch, Wnt, Fgf, Bmp and Shh) [...] and TBX3 in the development and maintenance of the epithelial lining of the urinary tract in the mouse Funding: DFG Molecular control of early urothelial differentiation in the murine ureter Funding: DFG

central importance for the regulation of developmental processes and tissue homeostasis. Using the mouse as the animal model of choice, and employing a combination of biochemical, molecular genetic, and [...] characterization of a number of these components both in vitro and in vivo, and the further analysis of mouse models. Our projects are supported by the German Research Council (DFG)

and in vivo imaging (fluorescence (confocal) microscopy, IVIS) disease mouse models LAD ligation in neonatal and adult mice mouse and rat cardiac cell fractionation histopathology analysis Projects: 1