Krankheiten, prä-klinischer Sicherheit, Wirksamkeitsmodellen (inkl. Monitoring und Imaging) sowie dem Design und der Anwendung einer passenden Zell- und/ oder Vektorproduktion (inkl. Genom Editierung). Erfolgreiche

Reaktogenität und Immunogenität von CVnCoV bei verschiedenen Dosierungen mithilfe eines adaptiven Dosisfindungsdesigns systematisch untersucht. Dies ermöglicht eine Dosissteigerung unter Verwendung vordefinierter

patients in centres for rare diseases (ZSE-DUO): a prospective, controlled trial with a two-phase cohort design. eClinicalMedicine Vol. 65. DOI: 10.1016/j.eclinm.2023.102260 Krüger K, Lapstich AM, Reber KC, Sehlen [...] Stahmeyer JT, Krauth C (2023). Lifestyle interventions for patients with non-alcoholic steato-hepatitis–Design, rationale and protocol of the study “target group-specific optimisation of lifestyle in [...] Krauth C (2021). How is and how should healthcare for people with multiple sclerosis in Germany be designed?-The rationale and protocol for the mixed-methods study Multiple Sclerosis-Patient-Oriented Care in

focus will be on how glycans can influence the efficiency of bone-marrow transplantation, and in the design of glycan-based strategies to improve this clinical procedure. Natalie Weber (Dr. med, PhD) Jahrgang

rodents 10:00-10:05 Break 10:05-11:05 3R-concept and applications 11:05-11:15 Break 11:15-12:30 Design and planning of animal experiments 12:30-12:45 Introduction to Q-Exam (exam preparation) Subject

isoforms complexed with the inhibitor AR-R17477 suggest a rational basis for specificity and inhibitor design. (2004) PNAS 101 , 5892-5897. Kottke T, Dick B, Fedorov R, Schlichting I, Deutzmannm R, Hegemann [...] provides new insights into RNA binding of the L1 protein family. (2000) Structure with Folding & Design 8 (4), 363-371. Fedorov R, Nevskaya N, Khairullina A, Tishchenko S, Mikhailov A, Garber M and Nikonov

been applied in unexpected way. In 1948, George Porter realized that high intensity flash tubes designed for nighttime aerial photography during World War II can generate a concentration of chemical species [...] were mainly concentrated on increasing of time resolution (down to few nanoseconds using specially designed coaxial flash lamps), improvement of detection techniques, and an extension of application to reactions

Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nat Commun 15(1): 411. Oleshko, O., N. Vollack-Hesse, A. Tiede, J. Hegermann, U. Curth and S. Werwitzke [...] K., and Hilgenfeld, R. (2020) Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors. Science 368, 409-412. Bogutzki, A., Naue, N., Litz, L., Pich

Community Day in Düsseldorf "Bioprocessing Technologies in Stem Cell Research: Perspectives on Process Design, Scale-Up, and Product Safety" Organised by Eppendorf AG Bioprocess Center TECHNOBEAT was the co

pharmacogenetics (polymorphisms) within psychopharmacological treatment. Further, the AMSP project is designed to inform about clinically relevant and/or new ADRs. Surveillance of drug therapy in psychiatry