r-Rezeptor-2. Bei Gallenwegstumoren ist FGFR2 aufgrund einer genetischen Fehlbildung mit anderen Genen sozusagen verschmolzen. Diese Fusionsumlagerungen führen zu einer dauerhaften Aktivierung von Signalwegen
questions remain unanswered. For example, in the majority of cases, it is unknown how and if the marker genes or regions are functionally involved in the cancerogenesis or progression. Likewise, it is unclear
herausragende Rolle. Aufgrund des erheblichen Polymorphismus der dem HLA-Komplex zugrunde liegenden Gene können derzeit an den transplantationsrelevanten HLA-Genorten A, B, C, DRB1, DQB1 und DPB1 mehr als
Science Publishers Link Kirsten Haastert-Talini Editorial for special issue: Gene Therapy approaches for Neuroregeneration Curr Gene Ther 2011 in press (Vol 11 No 2, April 2011) Ratzka A, Baron O, Grothe C [...] hypothesis. Placenta 2007;28(4):353-60. Kirsten Haastert, Claudia Grothe Gene Therapy in Peripheral Nerve Reconstruction Approaches Curr Gene Ther, 2007 Jun, 7:221-228 Grothe C and Timmer M The physiological [...] Vol. 108(3) 1–27. https://doi.org/10.1177/00368504251360728 The lincRNA Pantr1 is a FOXG1 target gene conferring site-specific chromatin binding of FOXG1. Gather F, Rauleac T, Akol I, Arumugam G, Fullio
cardiomyopathy (HCM) is one of the most commonly inherited cardiovascular diseases caused by mutations in genes encoding key cardiac sarcomeric proteins and is associated with a high risk of sudden cardiac death
S1 laboratory are equipped for genetic engineering work at safety level 1. CRISPR/Cas9 technology, gene expression and promoter activity studies using the GloMax Multi Detection System from Promega and
Down-Regulation of MHC Class I Expression in Human Keratinocytes Using Viral Vectors Containing US11 Gene of Human Cytomegalovirus and Cultivation on Bovine Collagen-Elastin Matrix (Matriderm®): Potential
organized by the European Society of Gene and Cell Therapy (ESGCT). The program brought together early-career researchers to expand their knowledge of current gene and cell therapy developments, while [...] during the poster session. New AAV vectors for cardiac-directed gene therapy July 2022 AAV vectors are promising delivery tools for human gene therapy. However, broad tissue tropism and pre-existing immunity [...] regulatory elements of hypoxia-sensitive genes in silico predicted the transcription factors SP1 and KLF5 as potential orchestrators in human endothelial hypoxic gene expression. Further studies revealed that
Becker JU , Cremer R, Hoefele J, Benz MR, Weber LT, Buettner R, Zerres K: Mutations in multiple PKD genes may explain early and severe polycystic kidney disease. J Am Soc Nephrol 2011; 22(11): 2047-56 Beutel [...] Wicke DC, Brugman MH, Meyer J, Schambach A, Büsche G , Ballmaier M, Baum C, Modlich U: Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia. [...] 32(2): 152-8 [German] Janciauskiene S, Ferrarotti I, Laenger F, Jonigk D, Luisetti M: Clinical utility gene card for: α-1-antitrypsin deficiency. Eur J Hum Genet 2011; 19(5): doi:10.1038/ejhg.2010.246 Jonigk
Gesundheitsforschung Förderung: Bundesministerium für Bildung und Forschung (BMBF) 09/2016-11/2016 GenE-TyPE: Genomeditierung – von Therapie über Prävention bis Verbesserung? (Genome Editing – from Therapy [...] paternalism?” Leitung: Prof. Dr. C. Woopen, ceres, Universität zu Köln Förderung: Fondation Brocher 2015 GenE-TyPE: Genomeditierung – von Therapie über Prävention bis Verbesserung? (Genome Editing – from Therapy