marker for human pluripotent stem cells’ 20.01.2021 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Prof. Dr. Doris Steinemann, Institut für Humangenetik, MHH: 'Repetitive sequences in human genomes and [...] Center of Pediatric Research, Indianapolis, USA: “Generation of human endothelial colony cells with vascular reparative properties from human induced pluripotent stem cells” 04.03.2014, Special lecture (1 [...] Hashomer, Israel and Dpt. of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University: Cell replacement therapy for diabetes: direct reprogramming of human adult cells into insulin

Fedorov, R., Henn, A., Taft, M. H. #, and Manstein, D. J.# (2020) Mechanochemical properties of human myosin 1C are modulated by isoform-specific differences in the N-terminal extension. J Biol Chem. [...] and Gunning, P. W. (2018) Co-polymers of Actin and Tropomyosin Account for a Major Fraction of the Human Actin Cytoskeleton. Curr. Biol. 28, 2331-2337.e5. doi: 10.1016/j.cub.2018.05.053. Latham, S. L., Ehmke [...] A. O., Taft, M. H. , Manstein, D. J., and Henn, A. (2017) N-terminal splicing extensions of the human MYO1C gene fine-tune the kinetics of the three full-length myosin IC isoforms. J. Biol. Chem. pii:

Kurzvita: 1997 - 2006 Studium der Humanmedizin an der Medizinischen Hochschule Hannover 05/2012- 07/2018 Assistenzärztin in Weiterbildung Klinik für Kinder- und Jugendpsychiatrie KRH Psychiatrie Wunstorf

Researcher: Eveleyne Deemkes, PhD Student Areas of expertise - Empowering cardiac cell therapy - Human in vitro models for disease modeling and drug screening - Improving translational animal models and

Habilitation an der MHH. Folgenden Vorlesungen „Herzentwicklung verstehen, Herzen heilen- das Potential humaner pluripotenter Stammzellen“ (Robert Zweigerdt) und „Pluripotente Stammzellen- Schlüssel zur Regeneration

The species D adenovirus E3/49K protein Human adenoviruses (Ads) comprise more than 90 different types that are classified into 7 species, A-G. In immunocompetent individuals Ads typically induce self-limiting [...] unit 3 (E3). The E3 region is not required for Ad replication in vitro, yet is preserved in all human Ads, indicating an important role for virus-host interaction in vivo . Supporting this view, previous [...] strong natural selection, which possibly is pathogen-driven. The intracellular parts of murine and human CD45 are 85.7% identical, whereas the identity for the extracellular domain is only 39.4%. Thus, the

disorders and beyond .” Prof. Dr. med. Nataliya Di Donato Group leader, Director Department for Human Genetics Email | ORCID Research Focus Uncovering Hidden Genetic Alterations in Rare and Complex Diseases [...] Analysis of (Rare) Genetic Variants Understanding genetic variants remains a major challenge in human genetics. Although advanced sequencing technologies allow us to identify even complex genomic variants [...] to as non-muscular actinopathies (NMA). Nevertheless, the full mutational and clinical spectrum of human monogenic disorders caused by ACTB or ACTG1 variants has yet to be systematically explored. Challenges

werden zytologische und HPV- Abstriche bei entsprechender Indikation entnommen, um eine Infektion mit Humanen Papillomviren auszuschließen bzw. bei Infektion die Hochrisikotypen zu identifizieren. Eine HPV-Impfung [...] Frauen, die zur Zervixkarzinom-Vorsorge gehen könnten, tun das nicht. Mit einem Selbstabstrich auf humane Papillomviren könnten auch diese Frauen erreicht werden. Dazu wurde auf dem Deutschen Krebskongress [...] gehört. Gebärmutterhalskrebs - Ist eine Impfung auch für Erwachsene sinnvoll? Die Impfung gegen das Humane Papillomvirus soll das Risiko von Gebärmutterhalskrebs deutlich verringern. Ein großes Versprechen

y, Leibniz University Hannover Pierina Cetraro Research Topic : Regulation of tRNA biogenesis by Human Cytomegalovirus infections Supervisor: Prof. Dr. Dan Depledge, Institute of Virology, MHH Academic [...] Chongqing Medical University, China Leonard Skremm Research Topic : Functional Inhibition of the Human Cytomegalovirus Immunoevasin pUL11 Supervisor: Dr. Penelope Kay-Fedorov, Institute of Virology, MHH [...] Sciences (UVAS), Lahore-Pakistan Camilo Torres Research Topic : Elucidating the mode-of-action of the human RNase 7 against herpes simplex virus type 1 Supervisor : Prof. Dr. Thomas Werfel, Clinic for Dermatology

Allosteric mechanisms underlying the enzymatic cycle and catalysis of human and pathogenic UGP were identified. For the octameric human UGP, we demonstrated that oligomerization plays a number of important [...] important functional roles that help hUGP to fulfill its function as an exclusive switch in human carbohydrate metabolism. In pathogen Leishmania major UGP (LmUGP) generates the NDP-pools for glycocalyx formation