K. Masjosthusmann, P. Deindl, D. Singer, M. Heidkamp, A. Schmidt, H. Ehrhardt. Trials. 2020 Oct 1;21(1):822. doi: 10.1186/s13063-020-04660-0. Sepsis related mortality of extremely low gestational age [...] Gille, M. Heckmann, J. Rupp, E. Herting, W. Göpel. Antimicrob Resist Infect Control. 2020 Aug 26;9(1):144. doi: 10.1186/s13756-020-00804-8. Active perinatal care of preterm infants in the German Neonatal [...] F-C Bange. J Hosp Infect. 2019 Jul;102(3):325-331. doi: 10.1016/j.jhin.2019.01.021. Epub 2019 Feb 1. Heart rate, respiratory rate, apnoeas and peripheral arterial oxygen saturation in healthy term neonates

remove bacteria from the blood stream: results of the first in human study. Crit Care. 2022 Jun 17;26(1):181. doi: 10.1186/s13054-022-04044-7. PMID: 35715801. Schmidt JJ, Borchina DN, Van't Klooster M, B [...] undergoing prolonged intermittent renal replacement therapy. J Antimicrob Chemother. 2021 Dec 24;77(1):169-173. doi: 10.1093/jac/dkab357. PMID: 34586373 Schmidt JJ, Strunk AK, David S, Bode-Böger SM, M [...] injury undergoing prolonged intermittent renal replacement therapy. J Antimicrob Chemother. 2019 Apr 1;74(4):997-1002. doi: 10.1093/jac/dky511. PMID: 30624668 Schmidt JJ, Lueck C, Ziesing S, Stoll M, Haller

detail for the NOD protein Apaf-1, the key switch in the mitochondrial pathway of apoptosis. Combining structural information from the X-ray structure of auto-inhibited Apaf-1 and the cryo-EM structure of [...] speck-like protein containing a caspase activation and recruitment domain ), and the effector pro-caspase 1. The transition from inactive monomer to active oligomer is characteristic for NOD proteins, to which [...] of the apoptosome, we depicted the conformational changes of Apaf-1, which eventually lead to the transduction of the cellular death signal. To understand the dynamics of the activation of NLRPs, we structurally

a novel CDH1-null tumour cell line from human lobular breast cancer. J Pathol 2009; 217(5): 620-32 Christgen M, Christgen H, Heil C, Krech T, Länger F, Kreipe H, Lehmann U: Expression of KAI1/CD82 in distant [...] Donowitz M, Yun C, Weinman EJ, Kocher O, Hogema BM, Seidler U: Differential roles of NHERF1, NHERF2, and PDZK1 in regulating CFTR-mediated intestinal anion secretion in mice. J Clin Invest 2009; 119(3): [...] Veröffentlichungen 2009 Ahrens P, Kreipe H: [BRCA1- and BRCA2- associated breast carcinomas.] Pathologe 2009; Suppl. 2: 207-209 [German] Athanassiadi K, Laenger F, Dickgreber N, Haverich A: Multiple i

-Produktion, die für GMP-Konformität und Automatisierung erforderlich ist. ( Abbildung 1 ). Figure 1: Abbildung 1: Schematischer Überblick über die hPSC-Produktions- und Differenzierungsstrategie in STBRs [...] HEK293T cells unveils disease-causing effects of Brugada mutation A735V of NaV1.5 sodium channels. Sci Rep. 2019 Aug 1;9(1):11173. doi: 10.1038/s41598-019-47632-4. PMID: 31371804; PMCID: PMC6673693. Iorga [...] Die Forschung ist in verschiedene, aber eng miteinander verknüpfte Themen und Projekte gegliedert: 1. Entwicklung von Bioprozessen für die klinische Umsetzung von hPSC-abgeleiteten Zelltypen , insbesondere

Marinović M, Faix J, Weber I. The IQGAP-related protein DGAP1 mediates signaling to the actin cytoskeleton as an effector and a sequestrator of Rac1 GTPases. Cell Mol Life Sci. 71, 2775-2785. Linkner J, Witte [...] expression in Spir-1 actin organizer mutant mice. Eur J Cell Biol. 93, 225-237. Winterhoff M, Junemann A, Nordholz B, Linkner J, Schleicher M, Faix J. The Diaphanous-related formin dDia1 is required for highly [...] regulate localization and activity of mDia1 formin. Eur J Cell Biol. 89, 723-733 Wiesner C, Faix J, Himmel M, Bentzien F, Linder S. KIF5B and KIF3A/KIF3B kinesins drive MT1-MMP surface exposure, CD44 shedding

Signale der intrazellulären Domäne von CSF-1R Schematische Darstellung der proteolytischen Prozessierung Makrophagen-kolonie-stimulierende Faktor-Rezeptor CSF-1R und mögliche Lokalisationen in der Zelle [...] Ich biete eine Masterarbeit zum Thema der 3D-Kultursysteme. Die Ausschreibung finden Sie im ILIAS. 1) Zell-Zell-Kontakte in Organoiden 3D-Co-Kultursystem mit Zellen, die von Hepatozyten abstammen (farblos) [...] . Ein Beispiel für derartige Signale ist der Makrophagen-kolonie-stimulierende Faktor-Rezeptor CSF-1R, der normalerweise nur in Phagozyten wie Makrophagen zu finden ist, aber aberrant auch in epithelialen

model for mortality and cardiovascular outcomes in older adults taking into account AZGP1. Sci Rep. 2021 Jun 3;11(1):11792. Haddad G, Kölling M, Wegmann UA, Dettling A, Seeger H, Schmitt R, Soerensen-Zender [...] emeinschaft PI: SCHM 2146/11-1, 2022-2025 Senolyse bei Nierenerkrankung: Therapeutisches Potential und Risiken Sponsor: Deutsche Forschungsgemeinschaft PI: SCHM 2146/10-1, 2020-2024 Offen Stellen und [...] Sörensen-Zender I, Rong S, Haller H, Schmitt R. The Therapeutic Potential of Zinc-Alpha2-Glycoprotein (AZGP1) in Fibrotic Kidney Disease. Int J Mol Sci. 2022 Jan 7;23(2):646. Liao CM, Wulfmeyer VC, Swallow M,

Extracorporeal membrane oxygenation in non-intubated immunocompromised patients. Crit Care. 2021 Apr 30;25(1):164. doi: 10.1186/s13054-021-03584-8. PMID: 33931122 Djenoune L, Tomar R, Dorison A, Ghobrial I, Schenk [...] Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model. Sci Rep. 2019 Nov 27;9(1):17718. doi: 10.1038/s41598-019-54058-5. PMID: 31776394 Stahl K*, Schenk H* , Seeliger B, Wiesner O [...] Schroder P, Bolaños-Palmieri P, Beese M, Hegermann J, Bräsen JH, Haller H. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish. Biomed Res Int.

School Carl-Neuberg-Strasse 1 30625 Hannover Principal Coordinating Investigator : Prof. Dr. med. Thomas Skripuletz Clinic for Neurology Hannover Medical School Carl-Neuberg-Strasse 1 30625 Hannover Trial protocol [...] print. Erratum in: JAMA Neurol. 2025 Jun 1;82(6):630. doi: 10.1001/jamaneurol.2025.1019. Combined treatment with allogeneic Epstein-Barr- and human polyomavirus 1 specific T-cells in progres-sive multifocal [...] Maecker-Kolhoff B, Eiz-Vesper B. J Clin Immunol. 2022 Apr;42(3):546-558. doi: 10.1007/s10875-021-01205-1. Epub 2022 Jan 6. Rapid generation of clinical-grade antiviral T cells: selection of suitable T-cell