remove bacteria from the blood stream: results of the first in human study. Crit Care. 2022 Jun 17;26(1):181. doi: 10.1186/s13054-022-04044-7. PMID: 35715801. Schmidt JJ, Borchina DN, Van't Klooster M, B [...] undergoing prolonged intermittent renal replacement therapy. J Antimicrob Chemother. 2021 Dec 24;77(1):169-173. doi: 10.1093/jac/dkab357. PMID: 34586373 Schmidt JJ, Strunk AK, David S, Bode-Böger SM, M [...] injury undergoing prolonged intermittent renal replacement therapy. J Antimicrob Chemother. 2019 Apr 1;74(4):997-1002. doi: 10.1093/jac/dky511. PMID: 30624668 Schmidt JJ, Lueck C, Ziesing S, Stoll M, Haller

detail for the NOD protein Apaf-1, the key switch in the mitochondrial pathway of apoptosis. Combining structural information from the X-ray structure of auto-inhibited Apaf-1 and the cryo-EM structure of [...] speck-like protein containing a caspase activation and recruitment domain ), and the effector pro-caspase 1. The transition from inactive monomer to active oligomer is characteristic for NOD proteins, to which [...] of the apoptosome, we depicted the conformational changes of Apaf-1, which eventually lead to the transduction of the cellular death signal. To understand the dynamics of the activation of NLRPs, we structurally

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model for mortality and cardiovascular outcomes in older adults taking into account AZGP1. Sci Rep. 2021 Jun 3;11(1):11792. Haddad G, Kölling M, Wegmann UA, Dettling A, Seeger H, Schmitt R, Soerensen-Zender [...] emeinschaft PI: SCHM 2146/11-1, 2022-2025 Senolyse bei Nierenerkrankung: Therapeutisches Potential und Risiken Sponsor: Deutsche Forschungsgemeinschaft PI: SCHM 2146/10-1, 2020-2024 Offen Stellen und [...] Sörensen-Zender I, Rong S, Haller H, Schmitt R. The Therapeutic Potential of Zinc-Alpha2-Glycoprotein (AZGP1) in Fibrotic Kidney Disease. Int J Mol Sci. 2022 Jan 7;23(2):646. Liao CM, Wulfmeyer VC, Swallow M,

Extracorporeal membrane oxygenation in non-intubated immunocompromised patients. Crit Care. 2021 Apr 30;25(1):164. doi: 10.1186/s13054-021-03584-8. PMID: 33931122 Djenoune L, Tomar R, Dorison A, Ghobrial I, Schenk [...] Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model. Sci Rep. 2019 Nov 27;9(1):17718. doi: 10.1038/s41598-019-54058-5. PMID: 31776394 Stahl K*, Schenk H* , Seeliger B, Wiesner O [...] Schroder P, Bolaños-Palmieri P, Beese M, Hegermann J, Bräsen JH, Haller H. Sulfatases, in Particular Sulf1, Are Important for the Integrity of the Glomerular Filtration Barrier in Zebrafish. Biomed Res Int.

School Carl-Neuberg-Strasse 1 30625 Hannover Principal Coordinating Investigator : Prof. Dr. med. Thomas Skripuletz Clinic for Neurology Hannover Medical School Carl-Neuberg-Strasse 1 30625 Hannover Trial protocol [...] print. Erratum in: JAMA Neurol. 2025 Jun 1;82(6):630. doi: 10.1001/jamaneurol.2025.1019. Combined treatment with allogeneic Epstein-Barr- and human polyomavirus 1 specific T-cells in progres-sive multifocal [...] Maecker-Kolhoff B, Eiz-Vesper B. J Clin Immunol. 2022 Apr;42(3):546-558. doi: 10.1007/s10875-021-01205-1. Epub 2022 Jan 6. Rapid generation of clinical-grade antiviral T cells: selection of suitable T-cell

Grassl, M Lochner. 2022. Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5(+) intestinal stem cell function. Nat Commun. 13(1):3998. Mamareli, P, F Kruse, C Lu, M Guderian, S [...] definiert werden. Unsere Arbeiten werden durch Zuwendungen der Deutschen Forschungsgemeinschaft (LO1415/7-1 und DFG Schwerpunktprogram 1937) sowie dem Land Niedersachsen (R2N) unterstützt. Mitarbeiter der AG [...] and innate lymphoid cell function during intestinal inflammation and infection. Mucosal Immunol. 14(1):164-176. Carriche, GM, L Almeida, P Stüve, L Velasquez, A Dhillon-LaBrooy, U Roy, M Lindenberg, T Strowig

Informationen sind unter folgenden externen Links abrufbar: https://patents.google.com/patent/US20170062645A1/en https://patents.google.com/patent/US9222074 Publikationen unserer Arbeitsgruppe An Y, Reimers K, [...] and insulin in human adipogenic differentiation models with adipose-derived stem cells. Adipocyte . 8(1):254-264. Schlottmann F, Strauss S, Hake K, Vogt PM, Bucan V (2019). Down-Regulation of MHC Class I [...] three-dimensional tissue cultures under static and dynamic culture conditions. BioResearch open access , 4 (1), 266-277. Strauß S, Neumeister A, Barcikowski S, Kracht D, Kuhbier JW, Radtke C, Reimers K, Vogt PM

NOD-like receptor NLRP1: implications for binding of muramyl dipeptide. FEBS Lett. 588 , 3327-3332. Yuan, S., Topf, M., Reubold, T.F. , Eschenburg, S., Akey, C.W. (2013) Changes in Apaf-1 conformation that [...] Inhibits T Cell Receptor Signaling. J. Virol. 97 , e0189822. doi: 10.1128/jvi.01898-22. Epub 2023 May 1. PMID: 37125921; PMCID: PMC10231199. Machtens, D.A., Willerding, J.M., Eschenburg, S., Reubold, T.F [...] 1420-1425. Reubold, T.F. , Wohlgemuth, S., Eschenburg, S. (2011) Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis. Structure 19 , 1074-1083

Viktor Grünwald, Andres J. Schrader, and Philipp Ivanyi. 2016. “Do Programmed Death 1 (PD-1) and Its Ligand (PD-L1) Play a Role in Patients with Non-Clear Cell Renal Cell Carcinoma?” Medical Oncology [...] Schrader, V. Grünwald, and P. Ivanyi. 2016. “Intratumoral Expression of Programmed Death Ligand 1 (PD-L1) in Patients with Clear Cell Renal Cell Carcinoma (CcRCC).” Medical Oncology 33(7):80. doi: 10. [...] Schmidtke. 2015. “Variants in TSPYL1 Are Not Associated with Sudden Infant Death Syndrome in a Cohort of Deceased Infants from Switzerland.” Molecular and Cellular Probes 29(1):31–34. doi: 10.1016/j.mcp.2014