defined states of differentation as a model for colonic ion transport“, magna cum laude Dr. rer. nat. Archana Kini, MHH Oktober 2019 „Genetic ablation of anion exchanger Slc26a3 results in colonic inflammation [...] intestine in vivo " (magna cum laude) Dr. med. Xuemei Liu, MHH 2014 "Expression and function of SLC26A9 - a member of SLC26 family in the airways and gastrointestinal tract" (summa cum laude) Dr. med. Stefan [...] and Murine CF Intestine: Differential Involvement of Apical HCO3- Transporters CFTR, Slc26a3 (DRA) and Slc26a6 (PAT-1)" (summa cum laude) Dr. med. Maria Lünnemann, MHH 2011 "Molekulare Pathophysiologie

the MHH is participating in a clinical intervention study on the effectiveness of two psychotherapy methods for persistent depression (changePDD). The study is financed with a total of over € 1,700,000 and [...] Products and Medical Devices, BfArM; the Medicines Commission of the German Medical Association (AkdÄ)) and is a member of the "European Network of Centres for Pharmacoepidemiology and Pharmacovigilance" ECsPP [...] five care clinics. For this purpose, a multiprofessional team provides guidance for patients with psychiatric disorders during and after the return to work to provide a long-term support. The implemented

living animals. PI: Dr. F.E. Müller , Dr. A. Zeug Recent publications: Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity. Cells 2023 Elucidating regulators [...] is involved in the regulation of the serotonin system and demonstrated a reduced palmitoylation status of serotonin receptor 1A within the prefrontal cortex in post-mortem samples from depressive patients [...] health burdens in western societies and a worldwide leading cause of morbidity and mortality. The major inflammatory reaction following the ischemic insult is a key reason for high mortality rates, and

countries: a panel data analysis. BMJ Open 2024;14:e077765. doi:10.1136/bmjopen-2023-077765 2023 Bartling T, Oedingen C , Schrem H, Kohlmann T, Krauth C (2023). Setting Organ Allocation Priorities: A Discrete [...] Krauth C, Oedingen C , Bartling T, Dreier M, Spura A, de Bock F, et al. (2021). Public preferences for exit strategies from COVID-19 lockdown in Germany – a discrete choice experiment. International Journal [...] Liersch S, Krüger K, Oedingen C , Spreenberg A, Bergemann T, Krauth C (2020). Evaluation of the pediatric-centered integrated care AOK Junior: protocol for a mixed-method study. BMC Health Services Research

the regulation of physiological responses to a variety of insults and serves as a protective control mechanism. The non-resolved inflammatory response plays a crucial role in the pathogenesis of many chronic [...] function and, in the long run, to the destruction of the tissues or organs involved. We search for a link between inflammation, small lipid mediators and the function and fate of beta cells. We aim to

1186/s13054-021-03584-8. PMID: 33931122 Djenoune L, Tomar R, Dorison A, Ghobrial I, Schenk H, Hegermann J, Beverly-Staggs L, Hidalgo-Gonzalez A, Little MH, Drummond IA. Autonomous Calcium Signaling in Human [...] print. PMID: 33911000 Etzrodt V, Idowu TO, Schenk H, Seeliger B, Prasse A, Thamm K, Pape T, Müller-Deile J, van Meurs M, Thum T, Garg A, Geffers R, Stahl K, Parikh SM, Haller H, David S. Role of endothelial [...] Bräsen JH, Haller H, Schiffer M. Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model. Sci Rep. 2019 Nov 27;9(1):17718. doi: 10.1038/s41598-019-54058-5. PMID: 31776394 Stahl

Research Our group aims at a detailed characterization of the enzyme UDP-glucose pyrophosphorylase (UGP) , a candidate drug target, from pathogenic species and the human host to identify structural and/or [...] human (Homo sapiens). PDB IDs: 4M2A , 8F73 and 4R7P. Images generated with UCSF ChimeraX. Schemes of organisms from Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3 [...] and/or mechanistic differences that would allow the development of specific inhibitors targeting UGP as a novel anti-infective drug target. We have previously studied UGP from the protozoan parasite Leishmania

(Dr. med.) supervisor: PD Dr. Ott, Abt. Gastroenterology a. Hepatology, OE 6810, project: Safety and efficacy of hepatocyte transplantation in a rabbit model of hereditable hypercholesterolemia Final exam [...] Skokowa RUSSIA supervisor: Prof.Dr. R. E. Schmidt, Clinical Immunology, OE 6830, project: C5a anaphylatoxin is a major regulator of FcyRs on alveolar macrophages in immune complex induced lung injury Final

without affecting the recipient's immune system. Our generated HLA-A*02-specific CAR Tregs approach is currently being evaluated in a phase I/II clinical trial. Further Information Publications You can [...] of organs available. Despite the advent of novel immunosuppressants, chronic organ rejection remains a challenge. Maintenance therapy is mandatory after organ transplantations. Immunosuppressive drugs are [...] does not interfere with the immune system and protects the transplanted organs from rejection. It is a promising and affordable way to overcome the problems of immunosuppression, its severe side effects

Iorga B., Fischer M., Geers-Knörr C., Hegermann J., Wrede C., Fiedler J., Kempf H., Franke A., Piep B., Pfanne A., Thum T., Martin U., Brenner B., Zweigerdt R., Kraft T. (2016) “Stiff matrix induces switch [...] (ISSN: 0031-6768), Vol.458(2):337-57 PubMed Iorga B., Blaudeck N., Solzin J., Neulen A., Stehle I., Lopez-Davila A. J., Pfitzer G., Stehle R. (2008) “Lys184 deletion in troponin I impairs relaxation kinetics [...] 77:676-686 PubMed Roels B., Reggiani C., Reboul C., LionneC., Iorga B., Obert P., Tanguy S., Gibault A., Jougla A., Travers F., Millet G., Candau R. (2008) “Paradoxial effects of endurance training and chronic