experience-dependent plasticity as a prerequisite for flexible behavior. Therefore, pathology-driven changes in the ability for homeostatic plasticity expression might represent a hallmark for the development [...] Transplantation and Vascular Surgery. The work is funded by a contract of the German Armed Forces (2022-2024). We have recently established a protocol for deriving human Schwann cells from human iPSCs and [...] body conditions, which are regulated by a complex interplay of different organs. To improve the biological relevance of neuroscientific research approaches, it is a major challenge to model inter-organ

experience-dependent plasticity as a prerequisite for flexible behavior. Therefore, pathology-driven changes in the ability for homeostatic plasticity expression might represent a hallmark for the development [...] Transplantation and Vascular Surgery. The work is funded by a contract of the German Armed Forces (2022-2024). We have recently established a protocol for deriving human Schwann cells from human iPSCs and [...] body conditions, which are regulated by a complex interplay of different organs. To improve the biological relevance of neuroscientific research approaches, it is a major challenge to model inter-organ

living animals. PI: Dr. F.E. Müller , Dr. A. Zeug Recent publications: Induced Remodelling of Astrocytes In Vitro and In Vivo by Manipulation of Astrocytic RhoA Activity. Cells 2023 Elucidating regulators [...] is involved in the regulation of the serotonin system and demonstrated a reduced palmitoylation status of serotonin receptor 1A within the prefrontal cortex in post-mortem samples from depressive patients [...] health burdens in western societies and a worldwide leading cause of morbidity and mortality. The major inflammatory reaction following the ischemic insult is a key reason for high mortality rates, and

defined states of differentation as a model for colonic ion transport“, magna cum laude Dr. rer. nat. Archana Kini, MHH Oktober 2019 „Genetic ablation of anion exchanger Slc26a3 results in colonic inflammation [...] intestine in vivo " (magna cum laude) Dr. med. Xuemei Liu, MHH 2014 "Expression and function of SLC26A9 - a member of SLC26 family in the airways and gastrointestinal tract" (summa cum laude) Dr. med. Stefan [...] and Murine CF Intestine: Differential Involvement of Apical HCO3- Transporters CFTR, Slc26a3 (DRA) and Slc26a6 (PAT-1)" (summa cum laude) Dr. med. Maria Lünnemann, MHH 2011 "Molekulare Pathophysiologie

Research Our group aims at a detailed characterization of the enzyme UDP-glucose pyrophosphorylase (UGP) , a candidate drug target, from pathogenic species and the human host to identify structural and/or [...] human (Homo sapiens). PDB IDs: 4M2A , 8F73 and 4R7P. Images generated with UCSF ChimeraX. Schemes of organisms from Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3 [...] and/or mechanistic differences that would allow the development of specific inhibitors targeting UGP as a novel anti-infective drug target. We have previously studied UGP from the protozoan parasite Leishmania

the MHH is participating in a clinical intervention study on the effectiveness of two psychotherapy methods for persistent depression (changePDD). The study is financed with a total of over € 1,700,000 and [...] Products and Medical Devices, BfArM; the Medicines Commission of the German Medical Association (AkdÄ)) and is a member of the "European Network of Centres for Pharmacoepidemiology and Pharmacovigilance" ECsPP [...] five care clinics. For this purpose, a multiprofessional team provides guidance for patients with psychiatric disorders during and after the return to work to provide a long-term support. The implemented

(Dr. med.) supervisor: PD Dr. Ott, Abt. Gastroenterology a. Hepatology, OE 6810, project: Safety and efficacy of hepatocyte transplantation in a rabbit model of hereditable hypercholesterolemia Final exam [...] Skokowa RUSSIA supervisor: Prof.Dr. R. E. Schmidt, Clinical Immunology, OE 6830, project: C5a anaphylatoxin is a major regulator of FcyRs on alveolar macrophages in immune complex induced lung injury Final

1186/s13054-021-03584-8. PMID: 33931122 Djenoune L, Tomar R, Dorison A, Ghobrial I, Schenk H, Hegermann J, Beverly-Staggs L, Hidalgo-Gonzalez A, Little MH, Drummond IA. Autonomous Calcium Signaling in Human [...] print. PMID: 33911000 Etzrodt V, Idowu TO, Schenk H, Seeliger B, Prasse A, Thamm K, Pape T, Müller-Deile J, van Meurs M, Thum T, Garg A, Geffers R, Stahl K, Parikh SM, Haller H, David S. Role of endothelial [...] Bräsen JH, Haller H, Schiffer M. Characterizing renal involvement in Hermansky-Pudlak Syndrome in a zebrafish model. Sci Rep. 2019 Nov 27;9(1):17718. doi: 10.1038/s41598-019-54058-5. PMID: 31776394 Stahl

without affecting the recipient's immune system. Our generated HLA-A*02-specific CAR Tregs approach is currently being evaluated in a phase I/II clinical trial. Further Information Publications You can [...] of organs available. Despite the advent of novel immunosuppressants, chronic organ rejection remains a challenge. Maintenance therapy is mandatory after organ transplantations. Immunosuppressive drugs are [...] does not interfere with the immune system and protects the transplanted organs from rejection. It is a promising and affordable way to overcome the problems of immunosuppression, its severe side effects

aster: 4 mm DIN A5 Broschüre (148 x 210 mm) 10 Spalten, Spaltenbreite 8,5 mm, Stegbreite 4 mm Ränder: Oben 9 mm, Unten 13 mm, Innen 19 mm, Außen 8 mm Grundlinienraster: 4 mm 1/3 DIN A4 Broschüre (99 x [...] und Anordnung von Bildern regelt. Schriftgrößen und Satzangaben finden Sie im Kapitel Schrift. DIN A4 Broschüre (210 x 297 mm) 12 Spalten, Spaltenbreite 10 mm, Stegbreite 5 mm Ränder: Oben 9 mm, Unten [...] Stegbreite 4 mm Ränder: Oben 9 mm, Unten 13 mm, Innen 9 mm, Außen 6 mm Grundlinienraster: 4 mm 1/3 DIN A4 Faltblatt (99 x 210 mm) 8 Spalten, Spaltenbreite 7 mm, Stegbreite 4 mm Ränder: Oben 9 mm, Unten 13