data reporting, we will thereby provide the basis for in silico models of the human brain that allow for predictions of adaptive processes in the human brain. (Reverse) Translation: By employing the parallel [...] plasticity as a prerequisite for flexible behavior. Therefore, pathology-driven changes in the ability for homeostatic plasticity expression might represent a hallmark for the development of clinical symptoms [...] neuroanatomists, human neocortical tissue – explanted during tumor or epilepsy surgery for medical or procedural indication – is used to investigate single-cell features in the human brain. Together with

Telefon (0176) 1532-6821. Die Originalarbeit „The COVID-19 Host Genetics Initiative. Mapping the human genetic architecture of COVID-19“ finden Sie hier . [...] Hepatologie und Endokrinologie und Direktor des Zentrums für Individualisierte Infektionsmedizin (Centre for Individualised Infection Medicine, CiiM), der sich um die klinische Aufarbeitung der an der HUB ei [...] ng. Die „COVID-19 Host Genomics Initiative“ ist eine der umfangreichsten Kooperationen in der Humangenetik und umfasst derzeit mehr als 3.500 Autorinnen und Autoren von 61 Studien aus 25 Ländern. Am h

vitro safety assays for gene therapy. Bastone, Antonella Lucía (PhD) Medizinische Hochschule Hannover, 2022 2021 Optimized Adeno-Associated Virus Vectors for Efficient Transduction of Human Retinal Organoids [...] AAV Capsids for Retinal Gene Therapy. Gehrke M, Diedrichs-Möhring M, Bogedein J, Büning H, Michalakis S, Wildner G. Cells 2022;11(12):1881 DOI: 10.3390/cells11121881 Development of genetic safety switches [...] Wirth D. J Mol Med (Berl) 2021;99(3):425-438 DOI: 10.1007/s00109-020-02020-8 Efficient Genetic Safety Switches for Future Application of iPSC-Derived Cell Transplants. Dahlke J, Schott JW, Vollmer Barbosa

sciences Practical courses for students of biochemistry, biology or life sciences Intramural collaborations: Clinics of Radiation Oncology Institute of Legal Medicine Institute of Experimental Hematology [...] biology of breast cancer Molecular genetics of ovarian cancer Molecular genetics of endometrial cancer Genetic epidemiology of cervical cancer Radiation sensitivity and DNA repair disorders Molecular basis of

of the renal pelvis (hydronephrosis). Congenital forms of these defects are frequently observed in human newborns defining an important task to understand normal and abnormal ureter development. Our current [...] cells in the highly specialized inner epithelial lining, the urothelium. We use a combination of genetic and pharmacological manipulations to explore the molecular, cellular and physiological consequences [...] consequences of loss- and gain-of-gene functions. All in all, this work may aid in establishing a paradigm for the molecular complexity guiding the development of a simple tubular organ. It may provide decisive

chemokine receptor expression on human eosinophils Final exam on November 7th, 2003 (Dr.rer.nat.) Veit Erpenbeck GERMANY (Dr. med.) supervisor: Prof. Dr. Krug, Fraunhofer-Institute, Nicolai-Fuchs-Str. 1, 30625 [...] Rudolph JAPAN (Watabe) supervisor: Prof. Dr. Gossler, Molecular Biology, OE 5250, project: Molecular Genetic Analysis of the Mouse RV-Gene (Baby pause in 2001) Final exam on November 12th, 2004. Gernot Sellge [...] Sellge GERMANY supervisor: Prof. Dr. Bischoff, Gastroenterology and Hepatology, OE 6810, project: Human intestinal mast cells: versatile cells of the intestinal immune system Final exam on November 7th, 2003

scope of our institute ranges from investigation of basic mechanisms of genetic cell modification to implementation of translational projects designed to establish improved conditions for clinical trials [...] therapeutics. Research at the Institute of Experimental Hematology (IEH) The ongoing improvement of gene transfer technologies for hematopoietic and other cell types has a great impact for the application in clinical [...] exchange (RMCE) techniques (Jürgen Bode) are major focuses in our institute. These technologies can be exploited to design entirely novel tools for gene therapy and to systematically modify ES- and iPS- cells

Prokein J, Illig T, Strech D (2016) Ethics Reporting in Biospecimen and Genetic Research: Current Practice and Suggestions for Changes. PLoS Biol 14(8):e1002521. Lennart M. Roesner, Heratizadeh A, Wieschowski [...] effects induced by the human autoallergen α-NAC. J Invest Dermatol. 2014 Jan; 134(6):1570-8 Hradetzky S , Balaji H, Rösner L, Heratizadeh A, Mittermann I, Valenta R, Werfel T: The human skin-associated au [...] Heratizadeh A, Crameri R, Garbani M, Scheynius A, Werfel T: Differential cytokine induction by the human skin-associated autoallergen thioredoxin in sensitized patients with atopic dermatitis and healthy

Research Research at the Institute of Transfusion Medicine and Transplant Engineering All research at the Institute of Transfusion Medicine and Transplant Engineering is designated to biotechnology approaches [...] identify patients at enhanced risk for viral infections as well as patients with viral infections that could not be controlled by conventional therapy. The manufacturing license for the GMP-compliant generation [...] focuses on the development of cellular therapeutics for cell replacement and regenerative therapies made from induced and optimized pluripotent stem cells for transfusion and transplantation purposes, including

funded project) Institute for Microbiology Institute for Legal Medicine Institute for Psychosomatic disorders Institute for Experimental Neurosurgery Institute for Clinical Chemistry Lab for Molecular Ne [...] Medical School, such as the Department for Transplantation medicine (related to alcohol-induced liver transplantations), the Institute for Pathology, and the Department for Neurosurgery. Aims of the research [...] Neuroscience External Institute for Psychiatry from Minden- Lübecke Clinics for Addiction Research, Zentral Institut Mannheim Paracelsus Medical Private University, Nürnberg Awards, Grants 03/2015: Internal