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endocytosis The pro-inflammatory cytokine IL-1 is a critical regulator of the innate immune response and the interleukin-1 (IL-1)-mediated signal transduction is a paradigm of immune signalling. IL-1 binding [...] binding, but the function of the IL-1RI internalization remained elusive. Recently, we demonstrated a critical role for the internalization of IL-1RI in the IL-1-mediated signal transduction. We also showed

therapeutic treatments. The group uses several in vitro and ex vivo models, with a particular focus on living myocardial slice. In a translational perspective, human myocardial slices are also extensively used [...] applied to both in vitro and in vivo research models. The group is testing these novel technologies in a regenerative medicine perspective. Working closely with the other research groups within Prof Thomas [...] development of novel therapeutic approaches HCM is the most frequent inherited cardiomyopathy with a prevalance of at least 1:500 in population. Thickening of left ventricular wall and interventricular

Siegel steht in drei Größen zur Verfügung. Verwendung Siegel, Größe 3: Format DIN A3 (z.B. Plakate) Siegel, Größe 2: Format DIN A4 (z.B. Broschüren, Briefbogen) Siegel, Größe 1: Format DIN lang (z.B. Flyer)

zur Zirrhose bis hin zum Leberkrebs fortschreiten lassen, sind nur unzureichend bekannt und hängen u.a. mit ernährungsbedingten und genetischen Risikofaktoren zusammen. In den letzten Jahren wurden mehrere [...] domain-containing protein 3“ (PNPLA3-I148M), welche mit der fortgeschrittenen NAFLD assoziiert ist u.a. unabhängig von BMI und/oder Diabetes Status. Die genauen Pathomechanismen, die auf die 148M-Variante [...] (einer Art Fastfood Diät) zeigen, dass die 148M-Variante zu einer besonders aggressiven NAFLD führt, u.a. auch mit der Entstehung einer mikrovesikulären Steatose. Besonders interessant war jedoch die Beobachtung

available in a pre-edited version (see below). The REIGN framework consists mainly of the Discussion Paper of the same name, and of the “REIGN Toolkit”. The Discussion Paper identifies a concrete framework [...] (Use of Research Evidence to Inform Guidance regarding Normative-ethical Topics) project to develop a framework explicating the role of evidence in the development of ethics guidelines. The resulting “REIGN [...] addresses theoretical background assumptions about the use of evidence in ethics. The “Toolkit” is a brief summary of this framework with, among other things, checklists that can be used when developing

neuropeptides. Other studies have reported that neurons in turn are influenced and primed by cytokines, a phenomenon well known through increased pain in locally inflamed tissue. How this bidirectional com [...] communication changes during aging is yet not been addressed. Chronic pain and itch conditions are a main source of decreased quality of life in the elderly population. Peripheral neuropathies effecting [...] proprioception are causing gait instability and increase the risk to fall and with this start a vicious cycle of morbidity and mortality. This project will be the first attempt to characterize and define

students and postdocs. Hannover Medical School is the only “medical faculty” in Germany which hosts such a large number of structured doctoral programs under the roof of one graduate school: Six (MD)/PhD programs [...] programs and three StrucMed programs, unique programs for undergraduate medical students to perform a Dr.med. thesis. Our Institute is currently part of the following teaching / education activities at [...] Medicine - PhD program Regenerative Sciences StrucMed-Program [ https://www.mhh.de/hbrs/strucmed ]. A structured 9-month program for MD students. Clinical lectures, Department of Cardiology and Angiology

Berufliche Tätigkeit: 2011-2013 Praktische Tätigkeit als Psychologische Psychotherapeutin in Ausbildung (PPiA) in der psychiatrischen Tagesklinik, auf der Station für schizophrene Spektrumserkrankungen sowie auf [...] 2013-2017 Praktische Tätigkeit als Psychologische Psychotherapeutin in fortgeschrittener Ausbildung (PPiA) in der Abteilung für Neuropsychologie der Klinik für Psychiatrie und Psychotherapie der Helios Dr. [...] z für Psychotherapie der Johannes Gutenberg-Universität Mainz (Leitung: Prof. Dr. M. Witthöft, Dr. A. Benecke) 2018 Praktische Tätigkeit als Psychologische Psychotherapeutin auf der Station für affektive

Meilensteins Svenja Hanna Bothe aus der Abteilung für Neurologie ' Investigation of compounds identified in a high-throughput screening in an in vitro model of Parkinson´s disease' Abhishek Chiyyeadu aus dem Institut [...] und den Leibniz Forschungslaboratorien für Biotechnologie und künstliche Organe (LEBAO) ‘Establishing a scalable bioreactor platform to generate human iPSC-derived hematopoietic cell types for regenerative [...] ve applications’ Ana-Maria Zamfirescu aus dem Institut für Zellbiochemie ‘The stem cell niche as a driver of ovarian organogenesis in Drosophila melanogaster ’ Wir wünschen Euch alles erdenklich Gute für