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with ARDS and septic shock. A special focus lies on evaluating current state of the art ECMO support as well as novel extracorporeal treatment modalities for septic shock. From a translational aspect, we [...] Our group was the first to prove in a murine knockout model that Angpt-2 directly contributes to sepsis morbidity and mortality. Based on this finding we have conducted a series of experiments exploring potential [...] EXCHANGE study program The hallmark of sepsis is a pathological host response to an infection that may lead to organ dysfunction, shock and ultimately to a high mortality. Besides numerous circulating mediators