Tau- and Aβ-induced synaptic degeneration on multiple levels, ranging from tissue culture models to human neocortical resections. Alongside investigations that elucidate ageing-related synaptic changes with [...] mie @ mh-hannover.de ). Key publications: All-trans retinoic acid induces synaptic plasticity in human cortical neurons. Lenz M, Kruse P, Eichler A, Straehle J, Beck J, Deller T, Vlachos A. Elife. 2021

haftliche und medizinische Doktorandinnen und Doktoranden auf dem Gebiet der Infektionsbiologie humaner intrazellulärer Infektionen in zehn wissenschaftlichen Teilprojekten umfassend und interdisziplinär [...] High-End-Omics-Techniken zur Analyse von Biomolekülen wie etwa DNA oder Proteinen, über die Herstellung humaner Organoide, also winziger organähnlicher Strukturen aus menschlichen Stammzellen, Methoden der Zell-

Kurzvita 2014 bis 2021: Studium der Humanmedizin an der Medizinischen Hochschule Hannover (MHH) 2021 bis 2022: Ärztin in Weiterbildung / Forschungs- und Lehrtätigkeit in der Klinik für Rheumatologie und

Kurzvita: 2009-2015 Studium der Humanmedizin an der Medizinischen Hochschule Hannover 12/2015 Approbation als Ärztin 2016-2019 Assistenzärztin für Innere Medizin in Hildesheim 2019-06/2023 Assistenzärztin

Wilmot tackles racism in its historic origins and contemporary forms. Within the realms of the humanities and civic education, she advocates for decolonial justice, empowerment and a critical diversit [...] After transitioning from academia and research, she supported international and German scientists in human resources development at the University of Cologne. Now, Phuong collaborates with universities and [...] After transitioning from academia and research, she supported international and German scientists in human resources development at the University of Cologne. Now, Phuong collaborates with universities and

Prinz I, Waskow C, Krueger A. Enhanced differentiation of functional human T cells in NSGW41 mice with tissue-specific expression of human interleukin-7. Leukemia. 2021 May 11. doi: 10.1038/s41375-021-01259-5 [...] 13;15(1):9841. doi: 10.1038/s41467-024-51673-3. PMID: 39537635. Ravens S, Tolosa E. Expansion of human γδ T cells in periphery: Lessons learned from development, infections, and compromised thymic function [...] Marcenaro E, Vivier E, Della Bella S, Mikulak J, Mavilio D. NKG2A expression identifies a subset of human Vδ2 T cells exerting the highest antitumor effector functions. Cell Rep. 2021 Oct 19;37(3):109871

heart (fibroblasts) is very similar in mouse and human, these observations are most likely also translatable to human models. Results translatable to human tissues? In the context of MEGFIB the research [...] 15?via%3Dihub August 2024 A reporter system for live cell tracking of human cardiomyocyte proliferation We have developed a human induced pluripotent stem cell (hiPSC) fluorescent reporter line to track [...] on an innovative ex vivo system - living human myocardial slices. For the first time, a new drug against heart failure was successfully tested on this living human heart tissue, resulting in a partial regression

disorders and beyond .” Prof. Dr. med. Nataliya Di Donato Group leader, Director Department for Human Genetics Email | ORCID Research Focus Uncovering Hidden Genetic Alterations in Rare and Complex Diseases [...] Analysis of (Rare) Genetic Variants Understanding genetic variants remains a major challenge in human genetics. Although advanced sequencing technologies allow us to identify even complex genomic variants [...] to as non-muscular actinopathies (NMA). Nevertheless, the full mutational and clinical spectrum of human monogenic disorders caused by ACTB or ACTG1 variants has yet to be systematically explored. Challenges

Allosteric mechanisms underlying the enzymatic cycle and catalysis of human and pathogenic UGP were identified. For the octameric human UGP, we demonstrated that oligomerization plays a number of important [...] important functional roles that help hUGP to fulfill its function as an exclusive switch in human carbohydrate metabolism. In pathogen Leishmania major UGP (LmUGP) generates the NDP-pools for glycocalyx formation

The species D adenovirus E3/49K protein Human adenoviruses (Ads) comprise more than 90 different types that are classified into 7 species, A-G. In immunocompetent individuals Ads typically induce self-limiting [...] unit 3 (E3). The E3 region is not required for Ad replication in vitro, yet is preserved in all human Ads, indicating an important role for virus-host interaction in vivo . Supporting this view, previous [...] strong natural selection, which possibly is pathogen-driven. The intracellular parts of murine and human CD45 are 85.7% identical, whereas the identity for the extracellular domain is only 39.4%. Thus, the