Skip Navigation
  • The MHH
  • International office
  • Emergency numbers
    • DE
    • EN
  • Patients & Visitors
  • Facilities & Departments
    • Facilities & Departments
    • MHH Clinical departments
    • MHH-Institutes
    • Clinical departments and institutes sorted by center
    • Interdisciplinary centers
    • Central facilities
  • Research
    • Research
    • Research foci
      • Research foci
      • COVID-19
    • Core Research Units
      • Core Research Units
      • MeDIC
      • Hannover Unified Biobank (HUB)
      • Lasermikroskopie
      • Research Core Unit Electron Microscopy
    • Academic Career Development
    • Advisory Services
      • Advisory Services
      • DFG
    • Research Infrastructure
    • Dean of Research
    • Good Scientific Practice
      • Good Scientific Practice
      • Commission for Good Scientific Practice
      • Ombuds Office and Ombudsperson
    • Transparency in Research
    • Research Funding, Knowledge & Technology Transfer
      • Research Funding, Knowledge & Technology Transfer
      • Partners & Networks
      • For life scientists
      • For partners & investors
      • For startups and founders
  • Studying at MHH
    • Studying at MHH
    • All degree programs
    • Registrar's Office
      • Registrar's Office
      • Prospective students
      • Students
      • Dates & deadlines
      • Contact
  • Careers
Welcome to the MHH Facilities & Departments MHH-Institutes Institute for Biophysical Chemistry Prof. Dr. Dietmar Manstein Research Interests and Methods

  • Actin
  • Myosin
  • Dynamin
  • Tropomyosin
  • Cell motility and cytoskeletal dynamics
  • Intracellular pathogen sensors
  • Protein structure, dynamics, reaction mechanisms, and allostery
  • Small-molecule based approaches targeting myosin function
  • Pharmacological chaperone-based approaches to treat muscle disorders and cytoskeletal protein-linked diseases
  • Bacterial and eukaryotic protein expression (E.coli; D. discoideum; Spodoptera frugiperda)
  • Protein purification (affinity-, ion-exchange, hydrophobic interaction, size-exclusion chromatography)
  • Time-resolved spectroscopy
  • Transient kinetics (stopped-flow, quenched-flow, flash photolysis of caged compounds, IR-laser induced temperature-jump)
  • Circular dichroism spectroscopy (CD)
  • Calorimetry (DSC and ITC)
  • Dynamic light scattering (DLS)
  • Microscale thermophoresis (MST)
  • Analytical ultracentrifugation techniques (sedimentation velocity AUC; sedimentation equilibrium AUC)
  • Differential scanning fluorescence (Thermo-Fluor assay)
  • Single molecule and live-cell imaging approaches
  • Confocal, evanescent field and spinning disk fluorescence microscopy
  • Macromolecular X-ray crystallography (crystallization robots, crystal imagers, X-ray generators & detectors)
  • Bioinformatics for integrated structural biology and hybrid methods
  • Computer-assisted drug-design (3D-workstations, High-Performance Computing Cluster)
Imprint Intranet Contact Privacy Accessibility
The MHH Hospital is a maximum care hospital with a nationwide catchment area. The university teaches medicine, dentistry, biochemistry, biomedicine, midwifery and health sciences. The main research areas are Transplantation and Stem Cell Research / Regenerative Medicine, Infection and Immunology Research, Biomedical Engineering and Implant Research.

   

Information about

Blood donation service MHH-Alumni e.V.

Follow us on

Facebook Instagram YouTube Xing LinkedIn
© 2019 - 2025 Medizinische Hochschule Hannover
Nach oben scrollen