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Welcome to the MHH MHH-Institutes Institute for Biophysical Chemistry Prof. Dr. Dietmar Manstein Research Interests and Methods
  • Welcome to the MHH
  • MHH-Institutes
  • Institute for Biophysical Chemistry
  • Prof. Dr. Dietmar Manstein
  • Research Interests and Methods
  • Prof. Dr. Dietmar Manstein

  • Actin
  • Myosin
  • Dynamin
  • Tropomyosin
  • Cell motility and cytoskeletal dynamics
  • Intracellular pathogen sensors
  • Protein structure, dynamics, reaction mechanisms, and allostery
  • Small-molecule based approaches targeting myosin function
  • Pharmacological chaperone-based approaches to treat muscle disorders and cytoskeletal protein-linked diseases
  • Bacterial and eukaryotic protein expression (E.coli; D. discoideum; Spodoptera frugiperda)
  • Protein purification (affinity-, ion-exchange, hydrophobic interaction, size-exclusion chromatography)
  • Time-resolved spectroscopy
  • Transient kinetics (stopped-flow, quenched-flow, flash photolysis of caged compounds, IR-laser induced temperature-jump)
  • Circular dichroism spectroscopy (CD)
  • Calorimetry (DSC and ITC)
  • Dynamic light scattering (DLS)
  • Microscale thermophoresis (MST)
  • Analytical ultracentrifugation techniques (sedimentation velocity AUC; sedimentation equilibrium AUC)
  • Differential scanning fluorescence (Thermo-Fluor assay)
  • Single molecule and live-cell imaging approaches
  • Confocal, evanescent field and spinning disk fluorescence microscopy
  • Macromolecular X-ray crystallography (crystallization robots, crystal imagers, X-ray generators & detectors)
  • Bioinformatics for integrated structural biology and hybrid methods
  • Computer-assisted drug-design (3D-workstations, High-Performance Computing Cluster)
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The MHH Hospital is a maximum care hospital with a nationwide catchment area. The university teaches medicine, dentistry, biochemistry, biomedicine, midwifery and health sciences. The main research areas are Transplantation and Stem Cell Research / Regenerative Medicine, Infection and Immunology Research, Biomedical Engineering and Implant Research.

   

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