New publication of the working group of PD Dr. Amar Deep Sharma

A new therapy with HNF4 mRNA reduces scarring in chronic liver disease

If fibrosis or cirrhosis develops in chronic liver disease, the only treatment option to date has been organ transplantation. Using a completely new approach aimed at restoring the central transcription factor HNF4A through nanoparticle-mediated application of mRNA, the research groups of PD Dr. Amar Deep Sharma and Prof. Michael Ott have now been able to show in several models of chronic liver damage that fibrotic remodeling can be reduced and the metabolic capacity of the liver restored. With this work, we have laid the foundations for a new class of therapies that are now being prepared for use in patients. The work has recently been published in the renowned "Journal of Hepatology" (Yang T, et al., J Hepatol, 2021).

For further information, please contact PD Dr. Amar Deep Sharma at: Sharma.Amar@mh-hannover.de