Reference systems and method development

 

Project management: Dr. D. Grote-Koska, Prof. Dr. K. Brand

 

Objectives: Reference systems consisting of reference methods and reference materials are used to test the analytical quality of routine procedures for clinical-chemical laboratory tests. The RfB reference laboratory is accredited as a calibration laboratory for
16 measurands in accordance with ISO/IEC 17025 and ISO 15195.

Various reference systems are currently being tested and developed. Various collaborations are maintained, e.g. with the Physikalisch-Technische Bundesanstalt (PTB) or in IFCC groups:

 

 

  • Reference system for the determination of pancreatic amylase in serum

  • Reference system for the determination of bilirubin in serum

  • Reference system for the determination of hemoglobin in blood

  • Reference system for pH measurement in plasma and blood

 

Head of reference laboratory:

Dr. D. Grote-Koska, EuSpLM
Phone: 0511 532 3862
email: grote-koska.denis@mh-hannover.de

A. Staaden, M. Sc. (Deputy Head)
Phone: 0511 532 2521
email: staaden.antje@mh-hannover.de

 

Funding: DGKL-RfB

 

Selected publications:

  • Rösch S, Frommeyer A, Schulte Bocholt J, Grote-Koska D, Brand K, Mischke R, Progression of cyclosporine A-blood levels in experimental cats receiving a high-dose treatment protocol.(2024). Front Vet Sci. 11:1444586.

  • Hinze CA, Fuge J, Grote-Koska D, Factors influencing voriconazole plasma level in intensive care patients.(2023). JAC Antimicrob. 6, dlae045.

  • Grote-Koska D, Czajkowski S, Staaden A, Brand K, Immunosuppressant Monitoring - Performance of the First Mass Spectrometry-Based Automated Clinical Analyzer Cascadion.(2023). Ther Drug Monit. 45: 14-19

  • Griemsmann M, Grote-Koska D, Cornberg M, Schmidt JJ, Maasoumy B; CirPK - Study Group. Plasma and ascites pharmacokinetics of meropenem in patients with decompensated cirrhosis and spontaneous bacterial peritonitis.(2022). J. Hepatol. 76: 230-233.

  • Kamp JC, Fuge J, Ringshausen FC, Grote-Koska D, Brand K, Graalmann L, Vonberg RP, Welte T, Rademacher J.(2021). Pharmacokinetics of Meropenem in People with Cystic Fibrosis-A Proof of Concept Clinical Trial. Antibiotics. 10: 292.

  • Grote-Koska D, Klauke R, Kaiser P, Kramer U, Macdonald R, Lerche D, Staaden A, Brand K, Schumann G.(2020). Total haemoglobin - a reference measuring system for improvement of standardization. Clin. Chem. Lab. Med. 58:1314-1321.

  • Grote-Koska D, Brand K.(2020). Using ISO/TS 20914:2019 to calculate the measurement uncertainty of immunosuppressive drugs in a clinical laboratory. Scand. j. Clin. Lab. Invest. 80:309-312.

  • Cheng THT, Tsui TKC, Kwok JSS, Lit LCW, Wong EYL, Kam RKT, Grote-Koska D, Staaden A, Okada H, Fuke N, Wong RSM, Li CK, Chan MHM.(2019). Comprehensive characterization and resolution of discrepant spectrophotometric bilirubin results in patients on eltrombopag therapy, Clin. Chem. Lab. Med. 58:1713-1723

  • Grote-Koska D, Klauke R, Brand K, Schumann G.(2018). Reference measurement procedure for the determination of electrolytes in human blood via ICP-OES measurement, Metrologia. 55: 245-253.
  • Klauke R, Kytzia HJ, Weber F, Grote-Koska D, Brand K, Schumann G.(2018). Reference measurement procedure for total bilirubin in serum re-evaluated and measurement uncertainty determined, Clin. Chim. Acta. 481: 115-120.
  • Deprez L, Toussaint B, Zegers I, Schimmel H, Grote-Koska D, Klauke R, Gella FJ, Orth M, Lessinger JM, Trenti T, Nilsson G, Ceriotti F.(2018). Commutability Assessment of Candidate Reference Materials for Pancreatic α-Amylase, Clin. Chem. 64: 1193-1202.
  • Grote-Koska D, Klauke R, Brand K, Schumann G.(2017). Alkaline phosphatase activity - pH impact on the measurement result, Clin. Chem. Lab. Med. 55: e146-e149.
  • Bikker R, Grote-Koska D, Domberg P, Brand K.(2017). Validity of two POCT glucose measurement devices in hypoglycaemia - how reliable is my result? Scand. j. Clin. Lab. Invest. DOI:10.1080/00365513.2017.1411971
  • Grote-Koska D, Czajkowski S, Brand K.(2015). Performance of the New RapidFire System for Therapeutic Monitoring of Immunosuppressants. Ther. Drug. Monit. 37: 400-404.
  • Grote-Koska D, Czajkowski S, Klauke R, Panten E, Brand K, Schumann G.(2014). A candidate reference measurement procedure for Cyclosporine A in whole blood. Accred. Qual. Assur. 19: 147-157.