Publications 2009-1990

2009

  • Purinergic signalling in rat GFSHR-17 granulosa cells: an in vitro model of granulosa cells in maturing follicles, W. Bintig, J. Baumgart, W. J. Walter, A. Heisterkamp, H. Lubatschowski, and A. Ngezahayo, Journal of Bioenergetics and Biomembranes (2009 Feb 4) 
  •  Force-Generating Cross-Bridges during Ramp-Shaped Releases: Evidence for a New Structural State, Radocaj A, Weiss T, Helsby WI, Brenner B, Kraft T., Biophys J. 2009 Feb 18;96(4):1430-1446, PubMed
  • Three-dimensional reconstruction of the Shigella T3SS transmembrane regions reveals 12-fold symmetry and novel features throughout,  Hodgkinson JL, Horsley A, Stabat D, Simon M, Johnson S, da Fonseca PC, Morris EP, Wall JS, Lea SM, Blocker AJ., Nat Struct Mol Biol. 2009 May;16(5):477-85. Epub 2009 Apr 26. PMID: 19396171
  • Globular tetramers of beta(2)-microglobulin assemble into elaborate amyloid fibrils, White HE, Hodgkinson JL, Jahn TR, Cohen-Krausz S, Gosal WS, Müller S, Orlova EV, Radford SE, Saibil HR., J Mol Biol. 2009 May 29;389(1):48-57. Epub 2009 Apr 5. PMID: 19345691
  • Cardiomyopathy mutations reveal variable region of myosin converter as major element of cross-bridge compliance, Seebohm B., Matinmehr F., Köhler J., Francino  A., Navarro-Lopez  F., Perrot  A., Özcelik  C., McKenna  W.J., Brenner  B., Kraft  T.,  Biophys J. 2009 Aug 5;97(3):806-24, PMID: 19651039
  • Burn-induced organ dysfunction: Vagus nerve stimulation attenuates organ and serum cytokine levels. Burns, Niederbichler AD, Papst S, Claassen L, Jokuszies A, Steinstraesser L, Hirsch T, Altintas MA, Ipaktchi KR, Reimers K, Kraft T, Vogt PM., 2009 May 29.Sep;35(6):783-9. Epub 2009 May 30.
  • The mechanism of pentabromopseudilin inhibition of myosin motor activity, Fedorov, R., Böhl, M., Tsiavaliaris, G., Hartmann, F.K., Taft, M.H., Baruch, P., Brenner, B., Martin, R., Knölker, H.-J., Gutzeit, H.O., Manstein, D.J., . Nat. Struc. Mol. Biol. 2009 16:80-88
  • Cytoplasmic dynein is not a conventional processive motor, Walter WJ, Brenner B, Steffen W.,  J Struct Biol. 2010 May;170(2):266-9. Epub 2009 Dec 2.
     

2008

  • Phosphorylation in C-Terminus of the Rat Connexin46 (rCx46) and Regulaton of the Conducting Activity of the Formed Connexons W. J. Walter, C. Zeilinger, W. Bintig, H.-A. Kolb, and A. Ngezahayo Journal of Bioenergetics and Biomembranes
  • What's the point of the T3SS needle? Blocker, A.J., Deane, J.E., Veenendaal, A.K.J., Roversi, P., Hodgkinson, J.L., Johnson, S. and Lea, S.M. (2008). Proc. Natl. Acad. Sci. USA. 105, 6507-13
     

2007

  • Quantification of Mutant versus Wild-Type Myosin in Human Muscle Biopsies Using Nano-LC/ESI-MS, Edgar Becker, Francisco Navarro-López, Antonio Francino, Bernhard Brenner and Theresia Kraft, Anal. Chem. 2007, 79,9531-9538
  •  Inorganic phosphate binds to the empty nucleotide binding pocket of conventional myosin II, Mamta Amrute-Nayak, Massimo Antognozzi, Tim Scholz, Hiroaki Kojima, and Bernhard Brenner, J Biol Chem. 2008 Feb 15;283(7):3773-81. Epub 2007 Dec 12.
  • A microtubule-based, dynein-dependent force induces local cell protrusions: Implications for neurite initiation. Dehmelt L, Nalbant P, Steffen W, Halpain S., Brain Cell Biol. 2007 Feb;35(1):39-56. Epub 2007 Mar 13. PMID: 17940912
  • Single Molecule Measurement of the Stiffness of the Rigor Myosin Head. Lewalle A, Steffen W, Stephenson O, Ouyang Z, Sleep J., Biophys J. 2007 Dec 7; PMID: 18065470
     

2006

  • The stroke size of myosins: a reevaluation,  Brenner B.,  J Muscle Res Cell Motil. 2006; 27:173-87
  • The kinesin KIF1C and microtubule plus ends regulate podosome dynamics in macrophagesKopp P, Lammers R, Aepfelbacher M, Woehlke G, Rudel T, Machuy N, Steffen W, Linder S. . Mol Biol Cell  17:2811-23. 2006
  • Tektin interactions and a model for molecular functions, Setter PW, Malvey-Dorn E, Steffen W, Stephens RE, Linck RW.,  Exp Cell Res 2006; 312:2880-96Vaccinia-Virus-Induced Cellular Contractility Facilitates the Subcellular Localization of the Viral Replication Sites, Schramm B, de Haan CA, Young J, Doglio L, Schleich S, Reese C, Popov A, Steffen W, Schroer T, Krijnse-Locker J. Traffic 2006; 7:1352-67

 Buchbeiträge

  • Direct labeling of components in protein complexes by immuno-electron microscopy, Hodgkinson JL, Steffen W. . In: Celis JE, editor. Cell Biology & Laboratory Handbook, 3rd edition. Academic Press; 2006. Vol. 3, p. 307-12
  • Application to the study of motor proteins, Steffen W, Lewalle A, Sleep J. Optical Tweezers: . In: Celis JE, editor. Cell Biology & Laboratory Handbook, 3rd edition. Academic Press; 2006. Vol. 3, p. 37-45

 

2005

  • A. Three-dimensional bead position histograms reveal single-molecule nanomechanics, Becker, N.B., Altmann, S.M., Scholz, T ., Hörber, J.K.H., Stelzer, E.H.K. und Rohrbach, . Physical Review E. 71 (2PT 1):021907.(2005)
  • Driving filament sliding: weak binding cross-bridge states, strong binding cross-bridge states, and the power stroke, Brenner B, Mählmann E, Mattei T, Kraft T. . Adv Exp Med Biol 2005; 565:75-91
  • Attenuation of cardiac remodeling after myocardial infarction by muscle LIM protein-calcineurin signaling at the sarcomeric Z-disc, Heineke J, Ruetten H, Willenbockel C, Gross SC, Naguib M, Schaefer A, Kempf T, Hilfiker-Kleiner D, Caroni P, Kraft T, Kaiser RA, Molkentin JD, Drexler H, and Wollert KC. Proc Natl Acad Sci U S A. 2005;102:1655-60. Epub 2005 Jan 21.
  • Hypertrophic cardiomyopathy-related ß-myosin mutations cause highly variable calcium sensitivity with functional imbalances among individual muscle cells,  Kirschner S.E., Becker E., Antognozzi M., Kubis H.-P., Francino A., Navarro-López F., Bit-Avagim N., Perrot A., Mirrakhimov M. M., Osterziel K.-J. , McKenna W.J., Brenner B., Kraft T. , Am J. Physiol. Heart Circ. Physiol. 288: 2005 
  • Initiation of the power stroke in muscle: insights from the phosphate analog AlF4,   Kraft T, Mählmann E, Mattei T, Brenner B. Proc Natl Acad Sci U S A. 2005, 102:13861-6. Epub 2005 Sep 20.
  • Mechanical properties of single myosin molecules probed with the Photonic Force Microscope, Scholz, T., Altmann, S.M., Antognozzi, M., Tischer, C., Hörber, J.K.H. und Brenner, B. . Biophys J. 2005; 88(1):360-371.

    Buchbeiträge

  •     Muskulatur. In: Klinke R, Pape HC, Silbernagl S. Physiologie. 5. Auflage. Stuttgart: Thieme Verlag; 2005, Brenner B
  •     Zelluläre Motilität. In: Klinke R, Pape HC, Silbernagl S. Physiologie. 5. Auflage. Stuttgart: Thieme Verlag; 2005, Korbmacher C, Greger R, Brenner B, Silbernagl S

 

2004

  • The Delta14 mutation of human cardiac troponin T enhances ATPase activity and alters the cooperative binding of S1-ADP to regulated actin, Gafurov B, Fredricksen S, Cai A, Brenner B, Chase PB, Chalovich JM. . Biochemistry 2004; 43:15276-85.
  • Heme oxygenase-1 inhibition of MAP kinases, calcineurin/NFAT signaling, and hypertrophy in cardiac myocytes, Tongers J, Fiedler B, Konig D, Kempf T, Klein G, Heineke J, Kraft T, Gambaryan S, Lohmann SM, Drexler H, Wollert KC. Cardiovasc Res. 2004; 63:545-52.

 

2003

  • Differential intranuclear localization of fibroblast growth factor-2 isoforms and specific interaction with the survival of motoneuron protein, Claus P, Doring F, Gringel S, Muller-Ostermeyer F, Fuhlrott J, Kraft T , Grothe C. J Biol Chem 2003; 278:479-85.
  • Downregulation of cytoskeletal muscle LIM protein by nitric oxide: impact on cardiac myocyte hypertrophy.  Heineke J, Kempf T, Kraft T , Hilfiker A, Morawietz H, Scheubel RJ, Caroni P, Lohmann SM, Drexler H, Wollert KC. Circulation 2003;107:1424-32.
  • Different degrees of lever arm rotation control myosin step size, Köhler D, Ruff C, Meyhöfer E, Bähler M. . J Cell Biol. 2003;161:237-241.
  •  Familial hypertrophic cardiomyopathy mutations in troponin I (K183., G203S, K206Q) enhance filament sliding, Köhler J, Chen Y, Brenner B, Gordon AM, Kraft T , Martyn DA, Regnier M, Rivera AJ, Wang C-K, Chase PB. Physiol. Genomics 2003;14:117-28.
  • Single Fungal Kinesin Motor Molecules Move Processively along Microtubules, Lakämper S, Kallipolitou A, Woehlke G, Schliwa M, Meyhöfer E.  Biophys J. 2003; 84:1833-43.
  • Actin sliding on reconstituted myosin filaments containing only one myosin heavy chain isoform, Scholz T, Brenner B. J Muscle Res Cell Motil 2003; 24:77-86.

 

2002

  • Toxoplasma gondii myosin A and its light chain: a fast, single-headed, plus-end-directed motor, Herm-Gotz A, Weiss S, Stratmann R, Fujita-Becker S, Ruff C, Meyhöfer E, Soldati T, Manstein DJ, Geeves MA, Soldati D. EMBO J. 2002; 21:2149-58.
  •  In vitro engineering of heart muscle: artificial myocardial tissue, Kofidis T., Akhyari P., Boublik J., Theodorou P., Martin U., Ruhparwar A., Fischer S., Eschenhagen T., Kubis HP., Kraft T ., Leyh R., Haverich A.: J. Thorac. Cardiovasc. Surg. 124(1):63-9 (2002).
  • Mutation of the myosin converter domain alters cross-bridge elasticity, Köhler J, Winkler G, Schulte I, Scholz T, McKenna W, Brenner B, Kraft T .  Proc Natl Acad Sci USA 2002; 99:3557-62.
  • Structural features of cross-bridges in isometrically contracting skeletal muscle,  Kraft, T., Mattei, T., Radocaj, A., Piep, B., Nocula, Ch., Furch, M., and Brenner, B.: . Biophys. J. 82(5):2536-47 (2002).

 

2001

  • Theoretical Kinetic Studies of Models for Binding Myosin Subfragment-1 to Regulated Actin: Hill Model versus Geeves Model, Chen, Y., Yan, B., Chalovich, J.M., and Brenner, B . Biophys. J. 80, 2338-2349 (2001).
  • Unusual properties of the fungal conventional kinesin neck domain from Neurospora crassa, Kallipolitou A, Deluca D, Majdic U, Lakämper S, Cross R, Meyhöfer E, Moroder L, Schliwa M, Woehlke G. EMBO J. 2001; 20:6226-35.
  • Single-molecule tracking of myosins with genetically engineered amplifier domains  Ruff, C., Furch, M., Brenner, B ., Manstein, D., and Meyhöfer, E.: . Nature Struc. Biol. 8, 226-229 (2001).

    Lehrbuchkapitel

  •     Muskeln und Motilität. In: Dudel, Menzel, Schmidt editors. Neurowissenschaft; vom Molekül zur Kognition. 2nd ed. Berlin, Heidelberg: Springer; 2001. p. 145-166, Rüdel R, Brenner B.

 

2000

  • Comparison of clinical performance, histology and single-fiber contractility in free neurovascular muscle flaps, Becker, M. H., Wermter, T. B., Brenner, B ., Walter, G.F., and Berger, A.  J Reconstr. Microsurg. Oct;16(7):525-34.(2000)
  •  Coupling of creatine kinase to glycolytic enzymes at the sarcomeric I-band of skeletal muscle: a biochemical study in situ,  Kraft, T., Hornemann, T., Stolz, M., Nier, V., and Wallimann, T.  J. Muscle Res. Cell Motil. 21, 691-703 (2000).
  • Cross-bridge attachment during high-speed active shortening of skinned fibers of the rabbit psoas muscle. Implications for cross-bridge action during maximum velocity of filament sliding, Stehle, R., and Brenner, B .Biophys. J. 78, 1458-1473 (2000).

 

1999

  • Kinetics of Thin Filament Activation Probed by Fluorescence of N-((2-Iodoacetoxy)ethyl)-N-methyl)amino-7-nitrobenz- 2-oxa-1,3-diazole-labelled Troponin I Incorporated in Skinned Fibers of Rabbit Psoas Muscle, Brenner, B. and Chalovich, J.M.: Implications for Regulation of Muscle Contraction. Biophys. J. 77, 2692-2708 (1999).
  • Thin filament activation probed by fluorescence of N-((2-Iodoacetoxy)ethyl)-N-methyl)amino-7-nitrobenz-2-oxa-1,3-diazole -labelled troponin I incorporated in skinned fibers of rabbit psoas muscle,    Brenner, B., Kraft, T., Yu, L.C., and Chalovich, J.M. Biophys. J. 77, 2677-2691 (1999).
  • Sarcomeric binding pattern of exogenously added intact caldesmon its C-terminal 20kDa fragment in skinned fibers of skeletal muscle, Frisbie, S.M., Reedy, M.C., Yu, L.C., Brenner, B ., Chalovich, J.M., and Kraft, T .   J. Muscle Res. Cell Motil. 20, 291-303 (1999).
  • The effect of thin filament activation on the attachment of weak binding cross-bridges: A 2D-Xray-diffraction study on single muscle fibers, Kraft, T., Xu, S., Brenner, B., and Yu, L.C.  Biophys. J. 76, 1494-1513 (1999).
  • Variability in the ratio of mutant to wildtype myosin heavy chain present in the soleus muscle of patients with familial hypertrophic cardiomyopathy. A new approach for the quantification of mutant to wildtype protein,  Nier, V., Schultz, I., Brenner, B ., Forssmann, W.-G., and Raida, M.  FEBS Letters, 461, 246-252 (1999).
  • A force transducer to measure the mechanical properties of single cardiac myocytes,  Tasche, C., Meyhöfer, E., and Brenner, B.   Am J. Physiol.-Heart and Circ. Physiol. 277, H2400-H2408 (1999).
  • In vitro sliding velocity of F-actin vs. unloaded shortening velocity in skinned muscle fibers, Thedinga, E., Karim, N., Kraft. T., and Brenner, B .  A single-fiber in vitro motility assay.J. Muscle Res. Cell Motil. 20, 785-796 (1999).

 

1998

  •  Muscle Mechanics II: skinned muscle fibres. In: Current Methods in Muscle Physiology, Brenner, B.: (H. Sugi, ed.) Oxford Univ. Press, pp. 33-69 (1998).
  •  Fluorescence of NBD-labeled troponin-I as a probe for the kinetics of thin filament activation in skeletal muscle fibers,  Brenner, B., Kraft, T., and Chalovich, J.M. Adv. Exp. Med. Mol. Biol. 453, 177-185 (1998).
  •  Structural features of force-generating cross-bridges: A 2D-X-ray diffraction study, Kraft, T., Mattei, T., Brenner, B.  Adv. Exp. Med. Biol. 289-296 (1998).
  • The isoenzyme-diagnostic regions of muscle-type creatine kinase, the M-260 and M-300 box. are not responsible for its binding to the myofibrillar M-band.   Stolz, M., Kraft, T ., Wallimann, T. Eur. J. Cell Biol. 77, 1-9 (1998).
  • Creatine kinase: An enzyme with a central role in cellular energy metabolism. Magentic Resonance Materials in Physics   Wallimann, T., Dolder, M., Schlattner, U., Eder, M., Hornemann, T., Kraft, T ., Stolz, M.,  Biology and Medicine 6, 116-119 (1998).
  •  X-ray diffraction studies of the cross-bridge intermediate states,  Xu, S., Malinchik, S., Frisbie, S., Gu, J., Kraft, T ., Rapp, G., Chalovich, J.M., Brenner, B ., and Yu, L.C. Adv. Exp. Med. Mol. Biol. 453, 271-277 (1998).

 

1997

  • Modulation of cross-bridge affinity for MgGTP by Ca 2+ in skinned fibers of rabbit psoas muscle, Frisbie, S.M., Chalovich, J.M., Brenner, B ., Yu, L.C. Biophys. J. 72, 2255-2261 (1997).
  • Inhibition of cross-bridge binding to actin by caldesmon fragments in skinned skeletal muscle fibers, Heubach, J.F., Hartwell, R., Ledwon, M., Kraft, T., Brenner, B ., Chalovich, J.M. . Biophys. J. 72, 1287-1294 (1997).
  • Force enhancement without changes in cross-bridge turnover kinetics: the effect of EMD 57033,  Kraft, T., Brenner, B.  Biophys. J. 72, 272-282 (1997).
  • X-ray diffraction studies of cross-bridges weakly bound to actin in relaxed skinned fibers of rabbit psoas muscle,  Xu, S., Malinchik, S., Gilroy, D., Kraft, Th., Brenner, B ., and Yu, L.C.: Biophys. J. 72, 2292-2303 (1997).

 

1996

  • Effect of antibody fragments against the N-terminus of actin on cross-bridge binding to actin and force generation in skinned fibers of the rabbit psoas muscle  Brenner, B., Kraft, T., DasGupta, G., Reisler, E.  Biophys. J. 70, 48-56 (1996).
  • Radial equilibrium lengths of acto-myosin cross-bridges in muscle,  Brenner, B., Xu, S., Chalovich, J.M., Yu, L.C. Biophys. J. 71, 2751-2758 (1996).

 

1995

  •  Distinct molecular processes associated with isometric force generation and with rapid tension recovery after quick release, Brenner, B., Chalovich, J.M., Yu, L.C. . Biophys. J. 68, 106s-111s (1995).
  •  Parallel inhibition of active force and relaxed fiber stiffness by caldesmon fragments at physiological temperature and ionic strength conditions. Additional evidence that weak cross-bridge binding to actin is an essential intermediate for force generation,  Kraft, T., Chalovich, J.M., Yu, L.C., Brenner, B. Biophys. J. 68, 2404-2418 (1995).
  • Equilibration and exchange of fluorescently labelled molecules in skinned skeletal muscle fibers visualized by confocal microscopy,  Kraft, T., Messerli, B. Rothen-Rutishauser, B., Perriard, J.-C., Wallimann, T., Brenner, B. . Biophys. J., 69, 1246-1258 (1995).
  • Equilibration of fluorescently labelled molecules in skeletal muscle fibers studied using confocal microscopy,   Kraft, T., Messerli, M., Rutishauser, B., Wallimann, T., Perriard, J.C., Chalovich, J.M., and Brenner, B. Biophys. J. 68, 371s (1995).

 

1993

  •  Dynamic actin interaction of cross-bridges during force generation. Implications for cross-bridge action in muscle,  Brenner, B.  Adv. Exp. Med. Biol. 332, 531-542 (1993).
  •  Mechanisms of changes in calcium sensitivity at the cross-bridge level. In: Modulation of Cardiac Calcium Sensitivity: A New Approach to Increasing the Strength of the Heart, Brenner, B.  J.A. Lee &  D.G. Allen (eds.), Oxford University Press (1993).
  •  Evidence for structural changes in cross-bridges during force generation.   Brenner, B., Yu, L.C. Adv. Exp. Med. Biol. 332, 461-467 (1993).
  •  Structural changes in the actomyosin cross-bridges associated with force generation,  Brenner, B., Yu, L.C.  Proc. Natl. Acad. Sci. USA 90, 5252-5256 (1993).
  •  On the regeneration of the actin-myosin power stroke in contracting muscle,  Chen, Y., Brenner, B . Proc. Natl. Acad. Sci. USA 90, 5148-5152 (1993).
  •  State-dependent radial elasticity of attached cross-bridges in single skinned fibres of rabbit psoas muscle,  Xu, S., Brenner, B ., Yu, L.C. J. Physiol. (Lond.) 461, 283-299 (1993).

 

1992

  •  Effect of Ca 2+ on weak cross-bridge interaction with actin in the presence of the nucleotide analog ATP, Kraft, Th., Yu, L.C., Kuhn, H.J., Brenner, B. , S. Proc. Natl. Acad. Sci. USA 89, 11362-11366 (1992).
     

1991

  •   Dynamic dissociation and reassociation of actomyosin cross-bridges during force-generation. A newly observed facet of cross-bridge action in muscle,  Brenner, B.  Proc. Natl. Acad. Sci. USA 88, 10490-10494 (1991).
  • Dynamic actin interaction of cross-bridges. A general principle and its implications for cross-bridge action in muscle, Brenner, B. Adv. Biophys. 27, 259-269 (1991).
  • A new concept for the mechanism of Ca 2+ -regulation of muscle contraction. Implications for physiological and pharmacological approaches to modulate contractile function of myocardium, Brenner, B.: Basic Res. Cardiol. 86,3, 83-92 (1991).
  • Characterization of radial force and radial stiffness in Ca 2+ -activated skinned fibres of the rabbit psoas muscle, Brenner, B., Yu. L.C. J. Physiol. (Lond.) 441, 703-718 (1991).
  • Parallel inhibition of active force and relaxed fiber stiffness in skeletal muscle by caldesmon. Implications for the pathway to force generation, Brenner, B., Yu, L.C., Chalovich, J.M. Proc. Natl. Acad. Sci. USA 88, 5739-5743 (1991)
  • Involvement of weak-binding cross-bridges in force production in muscle.  Chalovich, J.M., Yu, L.C., Brenner, B .  J. Muscle Res. Cell Motil. 12, 503-506 (1991)
  • Caldesmon derived polypeptides as probes of force production in skeletal muscle. In: Peptides as Probes in Muscle Research Chalovich, J.M., Yu, L.C., Velaz, L., Kraft, T., Brenner, B . , J.C. Rüegg (ed.) Springer, pp. 81-94 (1991)
  • Interference of myosin peptides with weak and strong actin interaction of cross-bridges in skeletal muscle fibers. I: Peptides as Probes in Muscle Research, Kraft, T., Rommel, U., Trayer, I.P., Brenner, B. , J.C. Rüegg (ed.) Springer, pp. 69-80 (1991)
  •  X-ray diffraction testing for weak-binding cross-bridges in relaxed bony fish muscle fibres at low ionic strength,  Squire, J.M., Podolsky, R.J., Barry, J.S., Yu, L.C., Brenner, B .  J. Struct. Biol. 107, 221-226 (1991)

 

1990

  • Muscle mechanics and biochemical kinetics. In: Molecular Mechanism of Muscular Contraction,  Brenner, B. . John Squire (ed.), Macmillan Press Ltd. pp. 77-149 (1990).