Clinical research (epidemiology, genetics, health economic aspects)
Prof. Dr. med. S. Petri / Prof. Dr. med. S. Körner
Staff members:
Prof. Dr. med. K. Kollewe, functional senior physician, specialist in neurology
Dr. med. Olivia Schreiber-Katz, specialist in neurology
Dr. med. Alma Osmanovic, assistant physician
Dr. med. Anna-Lena Boeck, specialist in neurology
Dr. med. Anastasia Sarikidi, assistant physician
Dr. med. Lars Müschen, assistant physician
Iraima Cespedes, assistant physician
Chantal Fischer, Study Coordinator
Clinical research - Amyotrophic lateral sclerosis (ALS):
Networks (Körner, Kollewe, Schreiber-Katz, Osmanovic, Sarikidi, Müschen, Cespedes)
As a partner in the German Network for Motor Neuron Diseases(http://www.mnd-als.de/html/home) and in the European ONWebDUALS patient registry (http://als.ibib.waw.pl/) (cooperation partners: M. de Carvalho, Lisbon, J. Grosskreutz, Jena, M. Kuźma-Kozakiewicz, M. Piotrkiewicz, Warsaw, P. Anderson, Umea; funding: EU Joint Program Neurodegenerative Disease Research), the ALS Center Hannover is involved in clinical and genetic research projects as well as clinical therapy studies, with a particular focus on electrophysiological issues and the search for risk and progression-modulating factors as well as health economic aspects and quality of life in ALS.
Imaging (Körner, Kollewe)
In cooperation with the Neurological University Hospital Magdeburg (Prof. Heinze, Prof. Vielhaber, Prof. Schreiber), studies are carried out with structural and functional imaging and ultrasound in the diagnosis and causal research of ALS patients.
Neuropsychology
In close cooperation with the working group of Prof. B. Kopp (Link?), a combination of neuropsychological test procedures and the measurement of event-related potentials is used to characterize the nature and development of cognitive and behavioural abnormalities that occur in up to 50% of ALS patients and to develop procedures for diagnosis and monitoring the course of the disease.
Genetics (Osmanovic)
In cooperation with Prof. Dr. R. Weber, Institute of Human Genetics, next generation sequencing (NGS) technologies are used to identify disease-associated genetic changes that can contribute to a better understanding of molecular mechanisms and genotype-phenotype correlations.
Clinical research - spinal muscular atrophy (SMA) (Osmanovic, Schreiber-Katz)
Patients with spinal muscular atrophy (SMA)(https://www.smartcare.de/) are recorded via the SmartCare register and the MND-Net.
A cohort of currently 30 SMA patients receiving the antisense oligonucleotide-based gene therapy with nusinersen, which has been approved at the MHH since 2017, is characterized with regard to therapy expectations, quality of life and subjective/objective methods for measuring therapy success.
Health economic aspect of neuromuscular diseases (Schreiber-Katz)
The aim of this research project is to establish a structured and systematic platform for health economic analyses of rare neurological diseases using standardized current health economic methods. This will enable health economic comparisons of current more or less palliative therapies with the complex causally effective drugs available in the future to be made according to international standards and important cost-benefit arguments for the invention of new drugs to be derived.
Contact:
Prof. Dr. med. Susanne Petri
Senior Physician
Clinical Department of Neurology
Hannover Medical School
Carl-Neuberg-Str. 1
30625 Hanover
Phone: 0511 - 532 3740
Fax: 0511 - 532 3115
E-Mail: Petri.Susanne@MH-Hannover.de