Biology (BM P 1) Cell Biology (BM P 2) Physiology/Pathophysiology (BM P 3) Immunology (BM P 4) Human Genetics (BM P 5) Virology (BM P 6) Responsibility in Biomedicine (BM P 7) Omics techniques, biostatistics

hepatic diseases and make them the target of innovative treatment strategies. To this end, we use human induced pluripotent stem cells (iPS cells) in many projects in order to have patient-specific stem [...] CRISPR/Cas9 technology for precise genome editing in order to be able to correct disease-specific genetic mutations in a targeted manner. With regard to the public debate on the use of pluripotent (embryonic) [...] genome editing procedures, we are involved in interdisciplinary discourse with partners in the humanities. Research projects Induced Pluripotent Stem Cell-Derived Hepatobiliary Organoids for Studies of

relevant. We have to learn to separate neutral from pathogenic variants from the large number of genetic changes. Bioinformatics will therefore play a decisive role not only in the evaluation of the enormous [...] gene variants." Doris Steinemann Staff members Doris Steinemann , Prof. Dr. rer. nat., specialist human geneticist, Director Winfried Hofmann , Dr. rer. nat., research associate, bioinformatics, deputy [...] development of a disease. To detect intronic and structural variants, we use state-of-the-art molecular genetic techniques such as genome sequencing and optical genome mapping (OGM; https://bionanogenomics.com)

Research In close cooperation with other Institutes of the MHH, we deal with a spectrum of different cell types as a therapeutic option for malignant and neurodegenerative diseases. T-cells CD20-CAR T [...] tion, MHH (Prof. M. Scherr) Induced pluripotent stem cells ( iPSC ) iPSC-derived macrophages - Institute of Experimental Haematology, MHH (Prof. T. Moritz, Prof. N. Lachmann) Mesenchymal stromal cells [...] Department of Neurology and Clinical Neurophysiology, MHH (Prof. S. Petri) Dendritic Z cells Induced, genetically modified dendritic cells as vaccines (iDCtWT1 ) - Clinical Department of Haematology, Haemostaseology

Surgery) on the MHH campus. Substantial recent progress in i) human induced pluripotent stem cell (hiPSC) reprogramming and tailored genetic engineering (RG Martin), ii) novel methods for hiPSC mass production

to humans. Research projects are concerned with the regulation of the human immune response to xenografts, as well as with the genetic modeling of donor pigs to prevent organ rejection in humans. The [...] antation, the transplantation of animal organs and cells into humans. So far, xenotransplantation has not been clinically tested in humans. In the Transregio 127 Collaborative Research Center, which has [...] comprises eleven closely interlinked scientific projects from seven MHH Clinical Departments and Institutes. All patients treated at the MHH for heart and lung failure with a circulatory or pulmonary support

Kispert A, von Wasielewski R, Brabant G: Identification of a Wnt/beta catenin signaling pathway in human thyroid cells. Endocrinology 2001; 142(12): 5261-6 Hogemann D, Flemming P, Kreipe H, Galanski M: [...] Flemming P, Yamamoto M, Shimahara Y, Yamaoka Y, Fukumoto M: Microsatellite instability and alternative genetic pathway in intrahepatic cholangiocarcinoma. J Hepathol 2001; 35(2): 235-44 Nave H, Mössinger E, Feist [...] 40(19): 7-14 Pötter E, Braun S, Lehmann U, Brabant G: Molecular cloning of a functional promoter of the human plakoglobin gene. Eur J Endocrinol 2001; 145(5): 625-33 Roth-Eichhorn S, Heitmann B, Flemming P, Kubicka

511 532 9563 Fax: +49 511 532 9565 @ brustzentrum @ mh-hannover.de Genetic counseling at the Breast Center Institute of Human Genetics Prof. Dr. med. Nataliya Di Donato Phone: +49 511 532 6533 @ online [...] appointment at the Breast Center Institute of Diagnostic and Interventional Radiology HR: Prof. Dr. med. F. Wacker Phone: +49 511 532 9569 Intensified early detection after genetic counseling Phone: +49 511 532 [...] Midwife Tel.: +49 511 532 6116, 6971, 6985 @ gross.mechthild @ mh-hannover.de Institute of Traditional Chinese Medicine (TCM) Institute of Traditional Chinese Medicine (TCM) Dr. W. Zheng Mon - Thu 08:00 - 15:00

cell-based therapies will provide innovative therapeutic strategies for the treatment of various genetic and acquired diseases. Recently, the possibility to reprogram normal somatic cells into induced [...] Martin - in collaboration with a group from Zürich - artificially introduced an ion channel into human iPS cells. Physiological occurrence of this ion channel is restricted to the thyroid and the stomach [...] Hoerstrup S, Luescher TF, Kaufmann PA, Landmesser U*, Martin U*: Transplantation and tracking of human-induced pluripotent stem cells in a pig model of myocardial infarction: assessment of cell survival

ISO 9001. The Institute of Human Genetics looks after families with a high incidence of breast and ovarian cancer and makes recommendations regarding screening intervals. At the Institute of Diagnostic [...] partners in the Breast Center can be found here. Breast diagnostics at the Institute of Diagnostic and Interventional Radiology Our Institute offers all common methods for the diagnosis and clarification of breast [...] Radiology in the Breast Center Dear patient, Welcome to the website of the Institute of Diagnostic and Interventional Radiology at the MHH Breast Center. In our Breast Center, the various specialist d