COVID-19 / SARS-CoV-2 Research at the MHH On this website we present the research studies and research achievements at the MHH on COVID-19. COVID-19 / SARS-CoV-2 Research at the MHH The MHH research team of Prof. Dr. Christian Könecke (on the right) publishes first European study of this kind in the Lancet journal "EBioMedicine". COVID-19 / SARS-CoV-2 Research at the MHH Research group of Prof. Dr. Reinhold Förster develops a simple test to detect protective neutralizing antibodies. COVID-19 / SARS-CoV-2 Research at the MHH From basic research to supramaximal care In addition to the research topics on Transplantation and Regeneration or Biomedical Engineering as well as Implants, the Hannover Medical School (MHH) is also well-known for the Infection Research . The MHH possesses a big network through partnerships with the Helmholtz Center for Infection Research (HZI), memberships in German Centers for Health Research as well as various collaborative research centers, the Cluster of Excellence RESIST and the HiGHmed Consortium. The MHH has lots of excellent internal (at the Campus), national and international collaborative research projects. The latter is also illustrated by the broad research funding of the MHH. to the projects Contact Coordination Local Coordination Unit (LokS) Patrick Kaufhold, Assistant Project Management E-Mail: num-loks @ mh-hannover.de Tel.: +49 (0) 511 532 83764 Dr. Tetyana Yevsa, Head of LokS E-Mail: num-loks @ mh-hannover.de Tel.: +49 (0) 511 532 83164 Publications on COVID-19 / SARS-CoV-2 research at the MHH sorted by a PubMed-ID (PMID) Publications with the PMID: 32143123 - 33368589 Cordes AK, Heim A. Rapid random access detection of the novel SARS-coronavirus-2 (SARS-CoV-2, previously 2019-nCoV) using an open access protocol for the Panther Fusion. J Clin Virol 2020;125:104305 DOI: S1386-6532(20)30047-0 Zhang L, Lin D, Sun X, Curth U, Drosten C, Sauerhering L, Becker S, Rox K, Hilgenfeld R. Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved alpha-ketoamide inhibitors. Science 2020;368(6489):409-412 DOI: 10.1126/science.abb3405 Wollenberg A, Flohr C, Simon D, Cork MJ, Thyssen JP, Bieber T, de Bruin-Weller MS, Weidinger S, Deleuran M, Taieb A, Paul C, Trzeciak M, Werfel T, Seneschal J, Barbarot S, Darsow U, Torrelo A, Stalder JF, Svensson A, Hijnen D, Gelmetti C, Szalai Z, Gieler U, De Raeve L, Kunz B, Spuls P, von Kobyletzki LB, Folster-Holst R, Chernyshov PV, Christen-Zaech S, Heratizadeh A, Ring J, Vestergaard C. European Task Force on Atopic Dermatitis statement on severe acute respiratory syndrome coronavirus 2 (SARS-Cov-2) infection and atopic dermatitis. J Eur Acad Dermatol Venereol 2020;34(6):e241-e242 DOI: 10.1111/jdv.16411 Albano D, Bertagna F, Bertoli M, Bosio G, Lucchini S, Motta F, Panarotto MB, Peli A, Camoni L, Bengel FM, Giubbini R. Incidental Findings Suggestive of COVID-19 in Asymptomatic Patients Undergoing Nuclear Medicine Procedures in a High-Prevalence Region. J Nucl Med 2020;61(5):632-636 DOI: 10.2967/jnumed.120.246256 Angus DC, Berry S, Lewis RJ, Al-Beidh F, Arabi Y, van Bentum-Puijk W, Bhimani Z, Bonten M, Broglio K, Brunkhorst F, Cheng AC, Chiche JD, De Jong M, Detry M, Goossens H, Gordon A, Green C, Higgins AM, Hullegie SJ, Kruger P, Lamontagne F, Litton E, Marshall J, McGlothlin A, McGuinness S, Mouncey P, Murthy S, Nichol A, O'Neill GK, Parke R, Parker J, Rohde G, Rowan K, Turner A, Young P, Derde L, McArthur C, Webb SA. The REMAP-CAP (Randomized Embedded Multifactorial Adaptive Platform for Community-acquired Pneumonia) Study. Rationale and Design. Ann Am Thorac Soc 2020;17(7):879-891 DOI: 10.1513/AnnalsATS.202003-192SD Boettler T, Newsome PN, Mondelli MU, Maticic M, Cordero E, Cornberg M, Berg T. Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID position paper. JHEP Rep 2020;2(3):100113 DOI: 10.1016/j.jhepr.2020.100113 Nicin L, Abplanalp WT, Mellentin H, Kattih B, Tombor L, John D, Schmitto JD, Heineke J, Emrich F, Arsalan M, Holubec T, Walther T, Zeiher AM, Dimmeler S. Cell type-specific expression of the putative SARS-CoV-2 receptor ACE2 in human hearts. Eur Heart J 2020;41(19):1804-1806 DOI: 10.1093/eurheartj/ehaa311 Hrusak O, Kalina T, Wolf J, Balduzzi A, Provenzi M, Rizzari C, Rives S, Del Pozo Carlavilla M, Alonso MEV, Dominguez-Pinilla N, Bourquin JP, Schmiegelow K, Attarbaschi A, Grillner P, Mellgren K, van der Werff Ten Bosch,J., Pieters R, Brozou T, Borkhardt A, Escherich G, Lauten M, Stanulla M, Smith O, Yeoh AEJ, Elitzur S, Vora A, Li CK, Ariffin H, Kolenova A, Dallapozza L, Farah R, Lazic J, Manabe A, Styczynski J, Kovacs G, Ottoffy G, Felice MS, Buldini B, Conter V, Stary J, Schrappe M. Flash survey on severe acute respiratory syndrome coronavirus-2 infections in paediatric patients on anticancer treatment. Eur J Cancer 2020;132:11-16 DOI: S0959-8049(20)30162-3 Gaborit BJ, Bergmann JF, Mussini C, Arribas JR, Behrens G, Walmsley S, Pozniak A, Raffi F. Plea for multitargeted interventions for severe COVID-19. Lancet Infect Dis 2020;20(10):1122-1123 DOI: S1473-3099(20)30312-1 Koch T, Dahlke C, Fathi A, Kupke A, Krahling V, Okba NMA, Halwe S, Rohde C, Eickmann M, Volz A, Hesterkamp T, Jambrecina A, Borregaard S, Ly ML, Zinser ME, Bartels E, Poetsch JSH, Neumann R, Fux R, Schmiedel S, Lohse AW, Haagmans BL, Sutter G, Becker S, Addo MM. Safety and immunogenicity of a modified vaccinia virus Ankara vector vaccine candidate for Middle East respiratory syndrome: an open-label, phase 1 trial. Lancet Infect Dis 2020;20(7):827-838 DOI: S1473-3099(20)30248-6 Teoh JYC, Roupret M, Shariat SF, Herrmann T. Intravesical therapy for bladder cancer in the pandemic of Covid-19. World J Urol 2020 DOI: 10.1007/s00345-020-03218-8 Gross S, Jahn C, Cushman S, Bar C, Thum T. SARS-CoV-2 receptor ACE2-dependent implications on the cardiovascular system: From basic science to clinical implications. J Mol Cell Cardiol 2020;144:47-53 DOI: S0022-2828(20)30121-8 Klimek L, Pfaar O, Worm M, Bergmann KC, Bieber T, Buhl R, Buters J, Darsow U, Keil T, Kleine-Tebbe J, Lau S, Maurer M, Merk H, Mosges R, Saloga J, Staubach P, Poethig D, Rabe K, Rabe U, Vogelmeier C, Biedermann T, Jung K, Schlenter W, Ring J, Chaker A, Wehrmann W, Becker S, Mulleneisen N, Nemat K, Czech W, Wrede H, Brehler R, Fuchs T, Tomazic PV, Aberer W, Fink-Wagner A, Horak F, Wohrl S, Niederberger-Leppin V, Pali-Scholl I, Pohl W, Roller-Wirnsberger R, Spranger O, Valenta R, Akdis M, Akdis C, Hoffmann-Sommergruber K, Jutel M, Matricardi P, Spertini F, Khaltaev N, Michel JP, Nicod L, Schmid-Grendelmeier P, Hamelmann E, Jakob T, Werfel T, Wagenmann M, Taube C, Bousquet J, Zuberbier T, Vogelberg C, Gerstlauer M. Allergen-Immuntherapie in der aktuellen Covid-19-Pandemie. Allergo J 2020;29(3):17-25 DOI: 10.1007/s15007-020-2539-9 Thum T. SARS-CoV-2 receptor ACE2 expression in the human heart: cause of a post-pandemic wave of heart failure? Eur Heart J 2020;41(19):1807-1809 DOI: 10.1093/eurheartj/ehaa410 Limbourg FP. Hypertension and RAAS inhibition in times of COVID-19 - current recommendations of the European Society of Hypertension. MMW Fortschr Med 2020;162(9):67-69 DOI: 10.1007/s15006-020-0483-y Gosch M, Zeeh J, Feddersen B, Michels G, Halek M, Bleckwenn M, Hauner H, Grabenhorst U, von Freyburg A, Limbourg F. MMW Fortschr Med 2020;162(9):5-020-0452-5 DOI: 10.1007/s15006-020-0452-5 Marlais M, Wlodkowski T, Vivarelli M, Pape L, Tonshoff B, Schaefer F, Tullus K. The severity of COVID-19 in children on immunosuppressive medication. Lancet Child Adolesc Health 2020;4(7):e17-e18 DOI: S2352-4642(20)30145-0 Ackermann M, Verleden SE, Kuehnel M, Haverich A, Welte T, Laenger F, Vanstapel A, Werlein C, Stark H, Tzankov A, Li WW, Li VW, Mentzer SJ, Jonigk D. Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19. N Engl J Med 2020;383(2):120-128 DOI: 10.1056/NEJMoa2015432 Napp LC, Bauersachs J. Extracorporeal Hemoadsorption: An Option for COVID-19-Associated Cytokine Storm Syndrome. Shock 2020;54(5):700-701 DOI: 10.1097/SHK.0000000000001568 Vogel-Claussen J, Ley-Zaporozhan J, Agarwal P, Biederer J, Kauczor HU, Ley S, Kuhl H, Mueller-Lisse UG, Persigehl T, Schlett CL, Wormanns D, Antoch G, Hamer OW. Recommendations of the Thoracic Imaging Section of the German Radiological Society for clinical application of chest imaging and structured CT reporting in the COVID-19 pandemic. Rofo 2020;192(7):633-640 DOI: 10.1055/a-1174-8378 Mariani S, Hanke JS, Dogan G, Schmitto JD. Out of hospital management of LVAD patients during COVID-19 outbreak. Artif Organs 2020;44(8):873-876 DOI: 10.1111/aor.13744 Winkler AS, Knauss S, Schmutzhard E, Leonardi M, Padovani A, Abd-Allah F, Charway-Felli A, Emmrich JV, Umapathi T, Satishchandra P, Hoo FK, Dalmau J, Oreja-Guevara C, Ferreira MLB, Pfausler B, Michael BD, Tagliavini F, Hoglinger G, Endres M, Klein C, Hemmer B, Carroll W, Sejvar J, Solomon T. A call for a global COVID-19 Neuro Research Coalition. Lancet Neurol 2020;19(6):482-484 DOI: S1474-4422(20)30150-2 Mohn N, Pul R, Kleinschnitz C, Pruss H, Witte T, Stangel M, Skripuletz T. Implications of COVID-19 Outbreak on Immune Therapies in Multiple Sclerosis Patients-Lessons Learned From SARS and MERS. Front Immunol 2020;11:1059 DOI: 10.3389/fimmu.2020.01059 Seifert J, Heck J, Eckermann G, Singer M, Bleich S, Grohmann R, Toto S. Psychopharmacotherapy during the COVID-19 pandemic. Nervenarzt 2020;91(7):604-610 DOI: 10.1007/s00115-020-00939-4 Mohn N, Saker F, Bonda V, Respondek G, Bachmann M, Stoll M, Wattjes MP, Stangel M, Skripuletz T. Mild COVID-19 symptoms despite treatment with teriflunomide and high-dose methylprednisolone due to multiple sclerosis relapse. J Neurol 2020;267(10):2803-2805 DOI: 10.1007/s00415-020-09921-1 Anker SD, Butler J, Khan MS, Abraham WT, Bauersachs J, Bocchi E, Bozkurt B, Braunwald E, Chopra VK, Cleland JG, Ezekowitz J, Filippatos G, Friede T, Hernandez AF, Lam CSP, Lindenfeld J, McMurray JJV, Mehra M, Metra M, Packer M, Pieske B, Pocock SJ, Ponikowski P, Rosano GMC, Teerlink JR, Tsutsui H, Van Veldhuisen DJ, Verma S, Voors AA, Wittes J, Zannad F, Zhang J, Seferovic P, Coats AJS. Conducting clinical trials in heart failure during (and after) the COVID-19 pandemic: an Expert Consensus Position Paper from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC). Eur Heart J 2020;41(22):2109-2117 DOI: 10.1093/eurheartj/ehaa461 Behrens GMN, Cossmann A, Stankov MV, Witte T, Ernst D, Happle C, Jablonka A. Perceived versus proven SARS-CoV-2-specific immune responses in health-care professionals. Infection 2020;48(4):631-634 DOI: 10.1007/s15010-020-01461-0 Ehrenreich H, Weissenborn K, Begemann M, Busch M, Vieta E, Miskowiak KW. Erythropoietin as candidate for supportive treatment of severe COVID-19. Mol Med 2020;26(1):58-020-00186-y DOI: 10.1186/s10020-020-00186-y Klimek L, Pfaar O, Worm M, Eiwegger T, Hagemann J, Ollert M, Untersmayr E, Hoffmann-Sommergruber K, Vultaggio A, Agache I, Bavbek S, Bossios A, Casper I, Chan S, Chatzipetrou A, Vogelberg C, Firinu D, Kauppi P, Kolios A, Kothari A, Matucci A, Palomares O, Szepfalusi Z, Pohl W, Hotzenecker W, Rosenkranz A, Bergmann KC, Bieber T, Buhl R, Buters J, Darsow U, Keil T, Kleine-Tebbe J, Lau S, Maurer M, Merk H, Mosges R, Saloga J, Staubach P, Jappe U, Rabe C, Rabe U, Vogelmeier C, Biedermann T, Jung K, Schlenter W, Ring J, Chaker A, Wehrmann W, Becker S, Freudelsperger L, Mulleneisen N, Nemat K, Czech W, Wrede H, Brehler R, Fuchs T, Tomazic PV, Aberer W, Fink Wagner A, Horak F, Wohrl S, Niederberger-Leppin V, Pali-Scholl I, Roller-Wirnsberger R, Spranger O, Valenta R, Akdis M, Matricardi PM, Spertini F, Khaltaev N, Michel JP, Nicod L, Schmid-Grendelmeier P, Idzko M, Hamelmann E, Jakob T, Werfel T, Wagenmann M, Taube C, Jensen-Jarolim E, Korn S, Hentges F, Schwarze J, O Mahony L, Knol E, Del Giacco S, Chivato T, Bousquet J, Zuberbier T, Akdis C, Jutel M. Anwendung von Biologika bei allergischen und Typ-2-entzündlichen Erkrankungen in der aktuellen Covid-19-Pandemie a, b, c: Positionspapier des Ärzteverbands Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C, der Österreichischen Gesellschaft für Allergologie und Immunologie (ÖGAI)D, der Luxemburgischen Gesellschaft für Allergologie und Immunologie (LGAI)E, der Österreichischen Gesellschaft für Pneumologie (ÖGP)F in Kooperation mit der deutschen, österreichischen, und schweizerischen ARIA-GruppeG und der Europäischen Akademie für Allergologie und Klinische Immunologie (EAACI)H Allergo J 2020;29(4):14-27 DOI: 10.1007/s15007-020-2553-y Dowsett M, Ellis MJ, Dixon JM, Gluz O, Robertson J, Kates R, Suman VJ, Turnbull AK, Nitz U, Christgen M, Kreipe H, Kuemmel S, Bliss JM, Barry P, Johnston SR, Jacobs SA, Ma CX, Smith IE, Harbeck N. Evidence-based guidelines for managing patients with primary ER+ HER2- breast cancer deferred from surgery due to the COVID-19 pandemic. NPJ Breast Cancer 2020;6:21-020-0168-9. eCollection 2020 DOI: 10.1038/s41523-020-0168-9 Stahl K, Bode C, David S. First do no harm-beware the risk of therapeutic plasma exchange in severe COVID-19. Crit Care 2020;24(1):363-020-03070-7 DOI: 10.1186/s13054-020-03070-7 Krettek C, Mittlmeier T, Mutschler W. COVID-19 pandemic: what do we know-what can we recommend? : Comments from the editors. Unfallchirurg 2020;123(7):579-020-00832-4 DOI: 10.1007/s00113-020-00832-4 Seffer MT, Martens-Lobenhoffer J, Schmidt JJ, Eden G, Bode-Boger SM, Kielstein JT. Clearance of chloroquine and hydroxychloroquine by the Seraph(R) 100 Microbind(R) Affinity blood filter - approved for the treatment of COVID-19 patients. Ther Apher Dial 2020 DOI: 10.1111/1744-9987.13549 Sipido KR, Antonanzas F, Celis J, Degos L, Frackowiak R, Fuster V, Ganten D, Gay S, Hofstraat H, Holgate ST, Krestin G, Manns M, Meunier F, Oertel W, Palkonen S, Pavalkis D, Rubsamen-Schaeff H, Smith U, Stallknecht BM, Zima T. Overcoming fragmentation of health research in Europe: lessons from COVID-19. Lancet 2020;395(10242):1970-1971 DOI: S0140-6736(20)31411-2 Pfeifer M, Ewig S, Voshaar T, Randerath WJ, Bauer T, Geiseler J, Dellweg D, Westhoff M, Windisch W, Schonhofer B, Kluge S, Lepper PM. Position Paper for the State-of-the-Art Application of Respiratory Support in Patients with COVID-19. Respiration 2020;99(6):521-542 DOI: 10.1159/000509104 Klimek L, Pfaar O, Worm M, Bergmann KC, Bieber T, Buhl R, Buters J, Darsow U, Keil T, Kleine-Tebbe J, Lau S, Maurer M, Merk H, Mosges R, Saloga J, Staubach P, Stute P, Rabe K, Rabe U, Vogelmeier C, Biedermann T, Jung K, Schlenter W, Ring J, Chaker A, Wehrmann W, Becker S, Mulleneisen N, Nemat K, Czech W, Wrede H, Brehler R, Fuchs T, Tomazic PV, Aberer W, Fink-Wagner A, Horak F, Wohrl S, Niederberger-Leppin V, Pali-Scholl I, Pohl W, Roller-Wirnsberger R, Spranger O, Valenta R, Akdis M, Akdis C, Hoffmann-Sommergruber K, Jutel M, Matricardi P, Spertin F, Khaltaev N, Michel JP, Nicod L, Schmid-Grendelmeier P, Hamelmann E, Jakob T, Werfel T, Wagenmann M, Taube C, Gerstlauer M, Vogelberg C, Bousquet J, Zuberbier T. Allergen immunotherapy in the current COVID-19 pandemic: A position paper of AeDA, ARIA, EAACI, DGAKI and GPA: Position paper of the German ARIA Group(A) in cooperation with the Austrian ARIA Group(B), the Swiss ARIA Group(C), German Society for Applied Allergology (AEDA)(D), German Society for Allergology and Clinical Immunology (DGAKI)(E), Society for Pediatric Allergology (GPA)(F) in cooperation with AG Clinical Immunology, Allergology and Environmental Medicine of the DGHNO-KHC(G) and the European Academy of Allergy and Clinical Immunology (EAACI)(H). Allergol Select 2020;4:44-52 DOI: 10.5414/ALX02147E Wagener FADTG, Pickkers P, Peterson SJ, Immenschuh S, Abraham NG. Targeting the Heme-Heme Oxygenase System to Prevent Severe Complications Following COVID-19 Infections. Antioxidants (Basel) 2020;9(6):10.3390/antiox9060540 DOI: E540 [pii] Kahl KG, Correll CU. Management of Patients With Severe Mental Illness During the Coronavirus Disease 2019 Pandemic. JAMA Psychiatry 2020;77(9):977-978 DOI: 10.1001/jamapsychiatry.2020.1701 Schmidt SB, Gruter L, Boltzmann M, Rollnik JD. Prevalence of serum IgG antibodies against SARS-CoV-2 among clinic staff. PLoS One 2020;15(6):e0235417 DOI: 10.1371/journal.pone.0235417 Polak WG, Fondevila C, Karam V, Adam R, Baumann U, Germani G, Nadalin S, Taimr P, Toso C, Troisi RI, Zieniewicz K, Belli LS, Duvoux C. Impact of COVID-19 on liver transplantation in Europe: alert from an early survey of European Liver and Intestine Transplantation Association and European Liver Transplant Registry. Transpl Int 2020 DOI: 10.1111/tri.13680 Panning M, Wiener J, Rothe K, Schneider J, Pletz MW, Rohde G, Rupp J, Witzenrath M, Spinner CD, Members of the CAPNETZ study group. No SARS-CoV-2 detection in the German CAPNETZ cohort of community acquired pneumonia before COVID-19 peak in March 2020. Infection 2020 DOI: 10.1007/s15010-020-01471-y Tzankov A, Jonigk D. Unlocking the lockdown of science and demystifying COVID-19: how autopsies contribute to our understanding of a deadly pandemic. Virchows Arch 2020;477(3):331-333 DOI: 10.1007/s00428-020-02887-5 Odak I, Barros-Martins J, Bosnjak B, Stahl K, David S, Wiesner O, Busch M, Hoeper MM, Pink I, Welte T, Cornberg M, Stoll M, Goudeva L, Blasczyk R, Ganser A, Prinz I, Forster R, Koenecke C, Schultze-Florey CR. Reappearance of effector T cells is associated with recovery from COVID-19. EBioMedicine 2020;57:102885 DOI: S2352-3964(20)30260-7 Scholz KH, Lengenfelder B, Thilo C, Jeron A, Stefanow S, Janssens U, Bauersachs J, Schulze PC, Winter KD, Schroder J, Vom Dahl J, von Beckerath N, Seidl K, Friede T, Meyer T. Impact of COVID-19 outbreak on regional STEMI care in Germany. Clin Res Cardiol 2020 DOI: 10.1007/s00392-020-01703-z Ackermann M, Mentzer SJ, Jonigk D. Pulmonary Vascular Pathology in Covid-19. Reply. N Engl J Med 2020;383(9):888-889 DOI: 10.1056/NEJMc2022068 Wang Y, Foo R, Thum T. Using "old" medications to fight new COVID-19: Re-purposing with a purpose. J Mol Cell Cardiol 2020;146:41-42 DOI: S0022-2828(20)30227-3 Jendrny P, Schulz C, Twele F, Meller S, von Kockritz-Blickwede M, Osterhaus ADME, Ebbers J, Pilchova V, Pink I, Welte T, Manns MP, Fathi A, Ernst C, Addo MM, Schalke E, Volk HA. Scent dog identification of samples from COVID-19 patients - a pilot study. BMC Infect Dis 2020;20(1):536-020-05281-3 DOI: 10.1186/s12879-020-05281-3 Wiesner O, Busch M, David S. Treatment of severe COVID-19 courses in intensive care medicine. Internist (Berl) 2020;61(8):804-812 DOI: 10.1007/s00108-020-00850-9 Buhl T, Beissert S, Gaffal E, Goebeler M, Hertl M, Mauch C, Reich K, Schmidt E, Schon MP, Sticherling M, Sunderkotter C, Traidl-Hoffmann C, Werfel T, Wilsman-Theis D, Worm M. COVID-19 and implications for dermatological and allergological diseases. J Dtsch Dermatol Ges 2020 DOI: 10.1111/ddg.14195 Gutenbrunner C, Stokes EK, Dreinhofer K, Monsbakken J, Clarke S, Cote P, Urseau I, Constantine D, Tardif C, Balakrishna V, Nugraha B. Why Rehabilitation must have priority during and after the COVID-19-pandemic: A position statement of the Global Rehabilitation Alliance. J Rehabil Med 2020;52(7):jrm00081-2713 DOI: 10.2340/16501977-2713 Marckmann G, Neitzke G, Schildmann J, Michalsen A, Dutzmann J, Hartog C, Jobges S, Knochel K, Michels G, Pin M, Riessen R, Rogge A, Taupitz J, Janssens U. Decisions on the allocation of intensive care resources in the context of the COVID-19 pandemic : Clinical and ethical recommendations of DIVI, DGINA, DGAI, DGIIN, DGNI, DGP, DGP and AEM. Med Klin Intensivmed Notfmed 2020 DOI: 10.1007/s00063-020-00709-9 Marckmann G, Neitzke G, Schildmann J, Michalsen A, Dutzmann J, Hartog C, Jobges S, Knochel K, Michels G, Pin M, Riessen R, Rogge A, Taupitz J, Janssens U. Decisions on the allocation of intensive care resources in the context of the COVID-19 pandemic : Clinical and ethical recommendations of DIVI, DGINA, DGAI, DGIIN, DGNI, DGP, DGP and AEM. German version. Med Klin Intensivmed Notfmed 2020;115(6):477-485 DOI: 10.1007/s00063-020-00708-w Dressler D, Adib Saberi F. Botulinum toxin therapy in the SARS-CoV-2 pandemic: patient perceptions from a German cohort. J Neural Transm (Vienna) 2020;127(9):1271-1274 DOI: 10.1007/s00702-020-02235-6 Hansmann G, Bezzerides V. Paediatric/congenital cardiology physician scientists-An endangered species. Eur J Clin Invest 2020;50(10):e13367 DOI: 10.1111/eci.13367 Karagiannidis C, Mostert C, Hentschker C, Voshaar T, Malzahn J, Schillinger G, Klauber J, Janssens U, Marx G, Weber-Carstens S, Kluge S, Pfeifer M, Grabenhenrich L, Welte T, Busse R. Case characteristics, resource use, and outcomes of 10 021 patients with COVID-19 admitted to 920 German hospitals: an observational study. Lancet Respir Med 2020;8(9):853-862 DOI: S2213-2600(20)30316-7 Salzberger B, Welte T. COVID-19-a new and many-sided challenge. Internist (Berl) 2020;61(8):773-775 DOI: 10.1007/s00108-020-00851-8 Degen C, Lenarz T, Willenborg K. Acute Profound Sensorineural Hearing Loss After COVID-19 Pneumonia. Mayo Clin Proc 2020;95(8):1801-1803 DOI: S0025-6196(20)30596-6 Yogeswaran A, Gall H, Tello K, Grunig E, Xanthouli P, Ewert R, Kamp JC, Olsson KM, Wissmuller M, Rosenkranz S, Klose H, Harbaum L, Lange TJ, Opitz CF, Waelde A, Milger K, Sommer N, Seeger W, Ghofrani HA, Richter MJ. Impact of SARS-CoV-2 pandemic on pulmonary hypertension out-patient clinics in Germany: a multi-centre study. Pulm Circ 2020;10(3):2045894020941682 DOI: 10.1177/2045894020941682 Kauczor HU, Welte T. The Role of CT in the Diagnosis of COVID-19-a State of Constant Flux. Dtsch Arztebl Int 2020;117(22-23):387-388 DOI: 10.3238/arztebl.2020.0387 Stover T, Dazert S, Hoffmann TK, Plontke SK, Ambrosch P, Arens C, Betz C, Beutner D, Bohr C, Bruchhage KL, Canis M, Dietz A, Guntinas-Lichius O, Hagen R, Hosemann W, Iro H, Klussmann JP, Knopf A, Kramer S, Lang S, Leinung M, Lenarz T, Lowenheim H, Matthias C, Mlynski R, Olze H, Park J, Plinkert P, Radeloff A, Rotter N, Rudack C, Bozzato A, Schipper J, Schrader M, Strieth S, Stuck BA, Volkenstein S, Westhofen M, Wolf G, Wollenberg B, Zahnert T, Zenk J. Effects of the SARS-CoV-2 pandemic on the otorhinolaryngology university hospitals in the field of medical care. Laryngorhinootologie 2020;99(10):694-706 DOI: 10.1055/a-1232-4911 Dona D, Torres Canizales J, Benetti E, Cananzi M, De Corti F, Calore E, Hierro L, Ramos Boluda E, Melgosa Hijosa M, Garcia Guereta L, Perez Martinez A, Barrios M, Costa Reis P, Teixeira A, Lopes MF, Kalicinski P, Branchereau S, Boyer O, Debray D, Sciveres M, Wennberg L, Fischler B, Barany P, Baker A, Baumann U, Schwerk N, Nicastro E, Candusso M, Toporski J, Sokal E, Stephenne X, Lindemans C, Miglinas M, Rascon J, Jara P, ERN TransplantChild. Pediatric transplantation in Europe during the COVID-19 pandemic: Early impact on activity and healthcare. Clin Transplant 2020:e14063 DOI: 10.1111/ctr.14063 Matuschek C, Moll F, Fangerau H, Fischer JC, Zanker K, van Griensven M, Schneider M, Kindgen-Milles D, Knoefel WT, Lichtenberg A, Tamaskovics B, Djiepmo-Njanang FJ, Budach W, Corradini S, Haussinger D, Feldt T, Jensen B, Pelka R, Orth K, Peiper M, Grebe O, Maas K, Gerber PA, Pedoto A, Bolke E, Haussmann J. Face masks: benefits and risks during the COVID-19 crisis. Eur J Med Res 2020;25(1):32-020-00430-5 DOI: 10.1186/s40001-020-00430-5 Schulte-Schrepping J, Reusch N, Paclik D, Bassler K, Schlickeiser S, Zhang B, Kramer B, Krammer T, Brumhard S, Bonaguro L, De Domenico E, Wendisch D, Grasshoff M, Kapellos TS, Beckstette M, Pecht T, Saglam A, Dietrich O, Mei HE, Schulz AR, Conrad C, Kunkel D, Vafadarnejad E, Xu CJ, Horne A, Herbert M, Drews A, Thibeault C, Pfeiffer M, Hippenstiel S, Hocke A, Muller-Redetzky H, Heim KM, Machleidt F, Uhrig A, Bosquillon de Jarcy L, Jurgens L, Stegemann M, Glosenkamp CR, Volk HD, Goffinet C, Landthaler M, Wyler E, Georg P, Schneider M, Dang-Heine C, Neuwinger N, Kappert K, Tauber R, Corman V, Raabe J, Kaiser KM, Vinh MT, Rieke G, Meisel C, Ulas T, Becker M, Geffers R, Witzenrath M, Drosten C, Suttorp N, von Kalle C, Kurth F, Handler K, Schultze JL, Aschenbrenner AC, Li Y, Nattermann J, Sawitzki B, Saliba AE, Sander LE, Deutsche COVID-19 OMICS Initiative (DeCOI). Severe COVID-19 Is Marked by a Dysregulated Myeloid Cell Compartment. Cell 2020;182(6):1419-1440.e23 DOI: S0092-8674(20)30992-2 Eckermann M, Frohn J, Reichardt M, Osterhoff M, Sprung M, Westermeier F, Tzankov A, Werlein C, Kuhnel M, Jonigk D, Salditt T. 3D virtual pathohistology of lung tissue from Covid-19 patients based on phase contrast X-ray tomography. Elife 2020;9:10.7554/eLife.60408 DOI: 10.7554/eLife.60408 Ivanyi P, Grullich C, Kroeger N, Gauler T, Johannsen M, Bedke J, Grunwald V, Interdisciplinary working group on renal tumors (IAG-N) of the German Cancer Socity (DKG). Systemic treatment of advanced/metastatic renal cell carcinoma in the context of SARS-CoV-2 pandemic: recommendations from the interdisciplinary working group for renal tumors (IAG-N). J Cancer Res Clin Oncol 2020;146(11):3075-3078 DOI: 10.1007/s00432-020-03341-4 Pfaar O, Klimek L, Worm M, Bergmann KC, Bieber T, Buhl R, Buters J, Darsow U, Keil T, Kleine-Tebbe J, Lau S, Maurer M, Merk H, Mosges R, Saloga J, Staubach P, Stute P, Rabe K, Rabe U, Vogelmeier C, Biedermann T, Jung K, Schlenter W, Ring J, Chaker A, Wehrmann W, Becker S, Mulleneisen N, Nemat K, Czech W, Wrede H, Brehler R, Fuchs T, Tomazic PV, Aberer W, Fink-Wagner A, Horak F, Wohrl S, Niederberger-Leppin V, Pali-Scholl I, Pohl W, Roller-Wirnsberger R, Spranger O, Valenta R, Akdis M, Akdis C, Hoffmann-Sommergruber K, Jutel M, Matricardi P, Spertini F, Khaltaev N, Michel JP, Nicod L, Schmid-Grendelmeier P, Hamelmann E, Jakob T, Werfel T, Wagenmann M, Taube C, Gerstlauer M, Vogelberg C, Bousquet J, Zuberbier T. Handling of allergen immunotherapy in the COVID-19 pandemic: An ARIA-EAACI-AeDA-GPA-DGAKI Position Paper (Pocket-Guide). Laryngorhinootologie 2020;99(10):676-679 DOI: 10.1055/a-1170-8426 Stahl K, Gronski PA, Kiyan Y, Seeliger B, Bertram A, Pape T, Welte T, Hoeper MM, Haller H, David S. Injury to the Endothelial Glycocalyx in Critically Ill Patients with COVID-19. Am J Respir Crit Care Med 2020;202(8):1178-1181 DOI: 10.1164/rccm.202007-2676LE Boettler T, Marjot T, Newsome PN, Mondelli MU, Maticic M, Cordero E, Jalan R, Moreau R, Cornberg M, Berg T. Impact of COVID-19 on the care of patients with liver disease: EASL-ESCMID position paper after 6 months of the pandemic. JHEP Rep 2020;2(5):100169 DOI: 10.1016/j.jhepr.2020.100169 Forster R, Fleige H, Sutter G. Combating COVID-19: MVA Vector Vaccines Applied to the Respiratory Tract as Promising Approach Toward Protective Immunity in the Lung. Front Immunol 2020;11:1959 DOI: 10.3389/fimmu.2020.01959 Wolff D, Nee S, Hickey NS, Marschollek M. Risk factors for Covid-19 severity and fatality: a structured literature review. Infection 2020 DOI: 10.1007/s15010-020-01509-1 Pinana JL, Xhaard A, Tridello G, Passweg J, Kozijn A, Polverelli N, Heras I, Perez A, Sanz J, Berghuis D, Vazquez L, Suarez-Lledo M, Itala-Remes M, Ozcelik T, Iturrate Basaran I, Karakukcu M, Al Zahrani M, Choi G, Cuesta Casas MA, Batlle Massana M, Viviana A, Blijlevens N, Ganser A, Kuskonmaz B, Labussiere-Wallet H, Shaw PJ, Arzu Yegin Z, Gonzalez-Vicent M, Rocha V, Ferster A, Knelange N, Navarro D, Mikulska M, de la Camara R, Styczynski J, Infectious Diseases Working Party of the European Society for Blood and Marrow Transplantation and Infectious Complications Subcommittee of the Spanish Hematopoietic Stem Cell Transplantation and Cell Therapy Group (GETH). Seasonal human coronaviruses respiratory tract infection in recipients of allogeneic hematopoietic stem cell transplantation. J Infect Dis 2020 DOI: jiaa553 Kommoss FKF, Schwab C, Tavernar L, Schreck J, Wagner WL, Merle U, Jonigk D, Schirmacher P, Longerich T. The Pathology of Severe COVID-19-Related Lung Damage. Dtsch Arztebl Int 2020;117(29-30):500-506 DOI: 10.3238/arztebl.2020.0500 Buhl T, Beissert S, Gaffal E, Goebeler M, Hertl M, Mauch C, Reich K, Schmidt E, Schon MP, Sticherling M, Sunderkotter C, Traidl-Hoffmann C, Werfel T, Wilsman-Theis D, Worm M. COVID‐19 und Auswirkungen auf dermatologische und allergologische Erkrankungen. J Dtsch Dermatol Ges 2020;18(8):815-825 DOI: 10.1111/ddg.14195_g Behrens GMN, Cossmann A, Stankov MV, Schulte B, Streeck H, Forster R, Bosnjak B, Willenzon S, Boeck AL, Thu Tran A, Thiele T, Graalmann T, Kayser MZ, Zychlinsky Scharff A, Dopfer C, Horke A, Pink I, Witte T, Wetzke M, Ernst D, Jablonka A, Happle C. Strategic Anti-SARS-CoV-2 Serology Testing in a Low Prevalence Setting: The COVID-19 Contact (CoCo) Study in Healthcare Professionals. Infect Dis Ther 2020 DOI: 10.1007/s40121-020-00334-1 Lu D, Chatterjee S, Xiao K, Riedel I, Wang Y, Foo R, Bar C, Thum T. MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes. J Mol Cell Cardiol 2020;148:46-49 DOI: S0022-2828(20)30274-1 Dopfer C, Wetzke M, Zychlinsky Scharff A, Mueller F, Dressler F, Baumann U, Sasse M, Hansen G, Jablonka A, Happle C. COVID-19 related reduction in pediatric emergency healthcare utilization - a concerning trend. BMC Pediatr 2020;20(1):427-020-02303-6 DOI: 10.1186/s12887-020-02303-6 Kuhlmann E, Falkenbach M, Klasa K, Pavolini E, Ungureanu MI. Migrant carers in Europe in times of COVID-19: a call to action for European health workforce governance and a public health approach. Eur J Public Health 2020;30(Supplement_4):iv22-iv27 DOI: 10.1093/eurpub/ckaa126 Michel S, Witt C, Gottlieb J, Aigner C. Impact of COVID-19 on Lung Transplant Activity in Germany-A Cross-Sectional Survey. Thorac Cardiovasc Surg 2020 DOI: 10.1055/s-0040-1715436 Windisch W, Weber-Carstens S, Kluge S, Rossaint R, Welte T, Karagiannidis C. Invasive and Non-Invasive Ventilation in Patients With COVID-19. Dtsch Arztebl Int 2020;117(31-32):528-533 DOI: 10.3238/arztebl.2020.0528 Osier F, Ting JPY, Fraser J, Lambrecht BN, Romano M, Gazzinelli RT, Bortoluci KR, Zamboni DS, Akbar AN, Evans J, Brown DE, Patel KD, Wu Y, Perez AB, Perez O, Kamradt T, Falk C, Barda-Saad M, Ariel A, Santoni A, Annunziato F, Cassatella MA, Kiyono H, Chereshnev V, Dieye A, Mbow M, Mbengue B, Niang MDS, Suchard M. The global response to the COVID-19 pandemic: how have immunology societies contributed? Nat Rev Immunol 2020;20(10):594-602 DOI: 10.1038/s41577-020-00428-4 Klimek L, Pfaar O, Worm M, Eiwegger T, Hagemann J, Ollert M, Untersmayr E, Hoffmann-Sommergruber K, Vultaggio A, Agache I, Bavbek S, Bossios A, Casper I, Chan S, Chatzipetrou A, Vogelberg C, Firinu D, Kauppi P, Kolios A, Kothari A, Matucci A, Palomares O, Szepfalusi Z, Pohl W, Hotzenecker W, Rosenkranz AR, Bergmann KC, Bieber T, Buhl R, Buters J, Darsow U, Keil T, Kleine-Tebbe J, Lau S, Maurer M, Merk H, Mosges R, Saloga J, Staubach P, Jappe U, Rabe KF, Rabe U, Vogelmeier C, Biedermann T, Jung K, Schlenter W, Ring J, Chaker A, Wehrmann W, Becker S, Freudelsperger L, Mulleneisen N, Nemat K, Czech W, Wrede H, Brehler R, Fuchs T, Tomazic PV, Aberer W, Fink-Wagner AH, Horak F, Wohrl S, Niederberger-Leppin V, Pali-Scholl I, Pohl W, Roller-Wirnsberger R, Spranger O, Valenta R, Akdis M, Matricardi PM, Spertini F, Khaltaev N, Michel JP, Nicod L, Schmid-Grendelmeier P, Idzko M, Hamelmann E, Jakob T, Werfel T, Wagenmann M, Taube C, Jensen-Jarolim E, Korn S, Hentges F, Schwarze J, O Mahony L, Knol EF, Del Giacco S, Chivato Perez T, Bousquet J, Bedbrook A, Zuberbier T, Akdis C, Jutel M. Use of biologicals in allergic and type-2 inflammatory diseases during the current COVID-19 pandemic: Position paper of Arzteverband Deutscher Allergologen (AeDA)(A), Deutsche Gesellschaft fur Allergologie und Klinische Immunologie (DGAKI)(B), Gesellschaft fur Padiatrische Allergologie und Umweltmedizin (GPA)(C), Osterreichische Gesellschaft fur Allergologie und Immunologie (OGAI)(D), Luxemburgische Gesellschaft fur Allergologie und Immunologie (LGAI)(E), Osterreichische Gesellschaft fur Pneumologie (OGP)(F) in co-operation with the German, Austrian, and Swiss ARIA groups(G), and the European Academy of Allergy and Clinical Immunology (EAACI)(H). Allergol Select 2020;4:53-68 DOI: 10.5414/ALX02166E Stahl K, Brasen JH, Hoeper MM, David S. Direct evidence of SARS-CoV-2 in gut endothelium. Intensive Care Med 2020;46(11):2081-2082 DOI: 10.1007/s00134-020-06237-6 Harke NN, Radtke JP, Hadaschik BA, Bach C, Berger FP, Blana A, Borgmann H, Distler FA, Edeling S, Egner T, Engels CL, Farzat M, Haese A, Hein R, Kuczyk MA, Manseck A, Moritz R, Musch M, Peters I, Pokupic S, Rocco B, Schneider A, Schumann A, Schwentner C, Sighinolfi CM, Buse S, Stolzenburg JU, Truss MC, Waldner M, Wulfing C, Zimmermanns V, Witt JH, Wagner C. To defer or not to defer? A German longitudinal multicentric assessment of clinical practice in urology during the COVID-19 pandemic. PLoS One 2020;15(9):e0239027 DOI: 10.1371/journal.pone.0239027 Kuhlmann E, Dussault G, Wismar M. Health labour markets and the 'human face' of the health workforce: resilience beyond the COVID-19 pandemic. Eur J Public Health 2020;30(Supplement_4):iv1-iv2 DOI: 10.1093/eurpub/ckaa122 von Meissner WCG, Strumann C, Kochen MM, Blickle PG, Wolk B, Pomsl J, Fink W, Steinhaeuser J. Clinical characteristics of SARS-CoV-2 infection in a rural area in Germany. Rural Remote Health 2020;20(3):6325 DOI: 10.22605/RRH6325 Grosshennig A, Koch A. COVID-19 hits a trial: Arguments against hastily deviating from the plan. Contemp Clin Trials 2020;98:106155 DOI: S1551-7144(20)30233-0 Muller F, Hummers E, Hillermann N, Dopfer C, Jablonka A, Friede T, Simmenroth A, Wetzke M. Factors Influencing the Frequency of Airway Infections in Underage Refugees: A Retrospective, Cross Sectional Study. Int J Environ Res Public Health 2020;17(18):10.3390/ijerph17186823 DOI: 10.3390/ijerph17186823 Graulich T, Gerhardy J, Graff P, Orgel M, Omar Pacha T, Krettek C, Macke C, Liodakis E. Patient volume, diagnosis and injury mechanisms in a level 1 trauma center at the beginning of the COVID-19 pandemic in comparison to the mean of the 3 previous years : A retrospective, epidemiological evaluation of 4967 patients. Unfallchirurg 2020;123(11):862-869 DOI: 10.1007/s00113-020-00894-4 Nelde A, Bilich T, Heitmann JS, Maringer Y, Salih HR, Roerden M, Lubke M, Bauer J, Rieth J, Wacker M, Peter A, Horber S, Traenkle B, Kaiser PD, Rothbauer U, Becker M, Junker D, Krause G, Strengert M, Schneiderhan-Marra N, Templin MF, Joos TO, Kowalewski DJ, Stos-Zweifel V, Fehr M, Rabsteyn A, Mirakaj V, Karbach J, Jager E, Graf M, Gruber LC, Rachfalski D, Preuss B, Hagelstein I, Marklin M, Bakchoul T, Gouttefangeas C, Kohlbacher O, Klein R, Stevanovic S, Rammensee HG, Walz JS. SARS-CoV-2-derived peptides define heterologous and COVID-19-induced T cell recognition. Nat Immunol 2020 DOI: 10.1038/s41590-020-00808-x Jakob CEM, Borgmann S, Duygu F, Behrends U, Hower M, Merle U, Friedrichs A, Tometten L, Hanses F, Jung N, Rieg S, Wille K, Gruner B, Klinker H, Gersbacher-Runge N, Hellwig K, Eberwein L, Dolff S, Rauschning D, von Bergwelt-Baildon M, Lanznaster J, Strauss R, Trauth J, de With K, Ruethrich M, Lueck C, Nattermann J, Tscharntke L, Pilgram L, Fuhrmann S, Classen A, Stecher M, Schons M, Spinner C, Vehreschild JJ. First results of the "Lean European Open Survey on SARS-CoV-2-Infected Patients (LEOSS)". Infection 2020 DOI: 10.1007/s15010-020-01499-0 Ackermann M, Mentzer SJ, Kolb M, Jonigk D. Inflammation and Intussusceptive Angiogenesis in COVID-19: everything in and out of Flow. Eur Respir J 2020 DOI: 2003147 Nugraha B, Wahyuni LK, Laswati H, Kusumastuti P, Tulaar AB, Gutenbrunner C. COVID-19 pandemic in Indonesia: Situation and challenges of rehabilitation medicine in Indonesia. Acta Med Indones 2020;52(3):299-305 https://pubmed.ncbi.nlm.nih.gov/33020342/ Schiller M, Pilette M, Rahlf B, von See C, Gellrich NC. Management of pandemic or large-scale emergencies in Germany with a focus on the current and potential role of university schools of dentistry: Can it help in COVID-19 time? Bull Natl Res Cent 2020;44(1):174-020-00427-4. Epub 2020 Oct 2 DOI: 10.1186/s42269-020-00427-4 Hermans ANL, van der Velden RMJ, Gawalko M, Verhaert DVM, Desteghe L, Duncker D, Manninger M, Heidbuchel H, Pisters R, Hemels M, Pison L, Sohaib A, Sultan A, Steven D, Wijtvliet P, Tieleman R, Gupta D, Dobrev D, Svennberg E, Crijns HJGM, Pluymaekers NAHA, Hendriks JM, Linz D, TeleCheck-AF investigators. On-demand mobile health infrastructures to allow comprehensive remote atrial fibrillation and risk factor management through teleconsultation. Clin Cardiol 2020 DOI: 10.1002/clc.23469 Kayser MZ, Valtin C, Greer M, Karow B, Fuge J, Gottlieb J. Video Consultation During the COVID-19 Pandemic: A Single Center's Experience with Lung Transplant Recipients. Telemed J E Health 2020 DOI: 10.1089/tmj.2020.0170 Giesen N, Sprute R, Ruthrich M, Khodamoradi Y, Mellinghoff SC, Beutel G, Lueck C, Koldehoff M, Hentrich M, Sandherr M, von Bergwelt-Baildon M, Wolf HH, Hirsch HH, Wormann B, Cornely OA, Kohler P, Schalk E, von Lilienfeld-Toal M. Evidence-based management of COVID-19 in cancer patients: Guideline by the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO). Eur J Cancer 2020;140:86-104 DOI: S0959-8049(20)30493-7 Boyle EC, Bleich A. R2N and the use of alternative methods in COVID-19 research. ALTEX 2020;37(4):683-684 DOI: 10.14573/altex.2010011 Busch M, Wiesner O, David S. Treatment of severe COVID-19 courses in intensive care medicine. Gastroenterologe 2020:1-8 DOI: 10.1007/s11377-020-00478-z Matterne U, Egger N, Tempes J, Tischer C, Lander J, Dierks ML, Bitzer EM, Apfelbacher C. Health literacy in the general population in the context of epidemic or pandemic coronavirus outbreak situations: Rapid scoping review. Patient Educ Couns 2020 DOI: S0738-3991(20)30547-4 Huber M, Rogozinski S, Puppe W, Framme C, Hoglinger G, Hufendiek K, Wegner F. Postinfectious Onset of Myasthenia Gravis in a COVID-19 Patient. Front Neurol 2020;11:576153 DOI: 10.3389/fneur.2020.576153 Qu Z, Oedingen C, Bartling T, Schrem H, Krauth C. Organ procurement and transplantation in Germany during the COVID-19 pandemic. Lancet 2020;396(10260):1395-6736(20)32213-3 DOI: S0140-6736(20)32213-3 Bosnjak B, Stein SC, Willenzon S, Cordes AK, Puppe W, Bernhardt G, Ravens I, Ritter C, Schultze-Florey CR, Godecke N, Martens J, Kleine-Weber H, Hoffmann M, Cossmann A, Yilmaz M, Pink I, Hoeper MM, Behrens GMN, Pohlmann S, Blasczyk R, Schulz TF, Forster R. Low serum neutralizing anti-SARS-CoV-2 S antibody levels in mildly affected COVID-19 convalescent patients revealed by two different detection methods. Cell Mol Immunol 2020 DOI: 10.1038/s41423-020-00573-9 Jonigk D, Markl B, Helms J. COVID-19: what the clinician should know about post-mortem findings. Intensive Care Med 2020 DOI: 10.1007/s00134-020-06302-0 Bojkova D, Bechtel M, McLaughlin KM, McGreig JE, Klann K, Bellinghausen C, Rohde G, Jonigk D, Braubach P, Ciesek S, Munch C, Wass MN, Michaelis M, Cinatl J,Jr. Aprotinin Inhibits SARS-CoV-2 Replication. Cells 2020;9(11):10.3390/cells9112377 DOI: E2377 Ruthrich MM, Giessen-Jung C, Borgmann S, Classen AY, Dolff S, Gruner B, Hanses F, Isberner N, Kohler P, Lanznaster J, Merle U, Nadalin S, Piepel C, Schneider J, Schons M, Strauss R, Tometten L, Vehreschild JJ, von Lilienfeld-Toal M, Beutel G, Wille K, LEOSS Study Group. COVID-19 in cancer patients: clinical characteristics and outcome-an analysis of the LEOSS registry. Ann Hematol 2020 DOI: 10.1007/s00277-020-04328-4 Klimek L, Worm M, Lange L, Beyer K, Rietschel E, Vogelberg C, Schnadt S, Stocker B, Brockow K, Hagemann J, Bieber T, Wehrmann W, Becker S, Freudelsperger L, Mulleneisen NK, Nemat K, Czech W, Wrede H, Brehler R, Fuchs T, Dramburg S, Matricardi P, Hamelmann E, Werfel T, Wagenmann M, Taube C, Zuberbier T, Ring J. Management von Anaphylaxie-gefährdeten Patienten während der Covid-19-Pandemie: Ein Positionspapier des Ärzteverbandes Deutscher Allergologen (AeDA)A, der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI)B, der Gesellschaft für Pädiatrische Allergologie und Umweltmedizin (GPA)C und des Deutschen Allergie- und Asthmabundes (DAAB)D. Allergo J 2020;29(7):16-26 DOI: 10.1007/s15007-020-2618-y Huppe D, Niederau C, Serfert Y, Hartmann H, Wedemeyer H, fur das DHC-R. Problems in treating patients with chronic HCV infection due to the COVID-19 pandemic and during the lockdown phase in Germany. Z Gastroenterol 2020 DOI: 10.1055/a-1291-8518 Saleh A, Matsumori A, Abdelrazek S, Eltaweel S, Salous A, Neumann FJ, Antz M. Myocardial involvement in coronavirus disease 19. Herz 2020 DOI: 10.1007/s00059-020-05001-2 Jung S, Kneer J, Kruger THC. Mental Health, Sense of Coherence, and Interpersonal Violence during the COVID-19 Pandemic Lockdown in Germany. J Clin Med 2020;9(11):10.3390/jcm9113708 DOI: 10.3390/jcm9113708 Feddersen N, Pape L, Beneke J, Brand K, Prufe J. Adherence in pediatric renal recipients and its effect on graft outcome, a single-center, retrospective study. Pediatr Transplant 2020:e13922 DOI: 10.1111/petr.13922 Hellmuth T, Hoppe D, Teschler S, Hoheisel R, Hillmann T. Recommendations of the German Respiratory Society (DGP) on Hygiene Measures During Treatment of Patients with Lung Diseases in the Outpatient Physiotherapy Practice in Times of the SARS-CoV-2 Pandemic. Pneumologie 2020. DOI: 10.1055/a-1305-7450 Page M, Almond N, Rose N J, Schneider C K. Diagnostics and the coronavirus: don't let the standards slip. Nat Biotechnol 2020 Jun;38(6):673-674 DOI: 10.1038/s41587-020-0558-4 Husain-Syed F, Vadasz I, Wilhelm J, Walmrath H D, Seeger W, Birk H W, Jennert B, Dietrich H, Herold S, Trauth J, Tello K, Sander M, Morty R E, Slanina H, Schuttler C G, Ziebuhr J, Kassoumeh S, Ronco C, Ferrari F, Warnatz K, Stahl K, Seeliger B, Hoeper M M, Welte T, David S. Immunoglobulin Deficiency as an Indicator of Disease Severity in Patients with COVID-19. Am J Physiol Lung Cell Mol Physiol 2020 Nov 25 DOI: 10.1152/ajplung.00359.2020 Lommatzsch M, Rabe K F, Taube C, Joest M, Kreuter M, Wirtz H, Blum T G, Kolditz M, Geerdes-Fenge H, Otto-Knapp R, Hacker B, Schaberg T, Ringshausen F C, Vogelmeier C F, Reinmuth N, Reck M, Gottlieb J, Konstantinides S, Meyer F J, Worth H, Windisch W, Welte T, Bauer T. Risk Assessment for Patients with Chronic Respiratory and Pulmonary Conditions in the Context of the SARS-CoV-2 Pandemic - Statement of the German Respiratory Society (DGP) with the Support of the German Association of Respiratory Physicians (BdP) Pneumologie (Stuttgart, Germany) 2021 Jan;75(1):19-30 DOI: 10.1055/a-1321-3400 Boyle E C, Haverich A. Microvasculature dysfunction as the common thread between atherosclerosis, Kawasaki disease, and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-associated multi-system inflammatory syndrome in children. Eur J Cardiothorac Surg. 2020 Dec 1;58(6):1109-1110. DOI: 10.1093/ejcts/ezaa367 Karst M, Hollenhorst J, Achenbach J. Life-threatening course in coronavirus disease 2019 (COVID-19): Is there a link to methylenetetrahydrofolic acid reductase (MTHFR) polymorphism and hyperhomocysteinemia? Med Hypotheses 2020 Nov;144:110234. Epub 2020 Sep 2 DOI: 10.1016/j.mehy.2020.110234 Welte T. SARS-CoV-2-Triggered Immune Reaction: For COVID-19, Nothing is as Old as Yesterday's Knowledge. Am J Respir Crit Care Med. 2021 Jan 15;203(2):156 DOI: 10.1164/rccm.202011-4194ED Fricke L M, Glockner S, Dreier M, Lange B. Impact of non-pharmaceutical interventions targeted at COVID-19 pandemic on influenza burden - a systematic review. J Infect . 2021 Jan;82(1):1-35. Epub 2020 Dec 3 DOI: 10.1016/j.jinf.2020.11.039 Kocaturk E, Salman A, Cherrez-Ojeda I, Ricardo Criado P, Peter J, Comert-Ozer E, Abuzakouk M, Camara Agondi R, Al-Ahmad M, Altrichter S, Arnaout R, Karla Arruda L, Asero R, Bauer A, Ben-Shoshan M, Bernstein J A, Bizjak M, Boccon-Gibod I, Bonnekoh H, Bouillet L, Brzoza Z, Busse P, Campos R A, Carne E, Conlon N, Criado R F, de Souza Lima E M, Demir S, Dissemond J, Dogan Gunaydin S, Dorofeeva I, Felipe Ensina L, Ertas R, Mariel Ferrucci S, Figueras-Nart I, Fomina D, Franken S M, Fukunaga A, Gimenez-Arnau A M, Godse K, Goncalo M, Gotua M, Grattan C, Guillet C, Inomata N, Jakob T, Karakaya G, Kasperska-Zajac A, Katelaris C H, Kosnik M, Krasowska D, Kulthanan K, Sendhil Kumaran M, Lang C, Ignacio Larco-Sousa J, Lazaridou E, Anika Leslie T, Lippert U, Calderon Llosa O, Makris M, Marsland A, Medina I V, Meshkova R, Bastos Palitot E, Parisi C A S, Pickert J, Ramon G D, Rodriguez-Gonzalez M, Rosario N, Rudenko M, Rutkowski K, Sanchez J, Schliemann S, Enis Sekerel B, Serpa F S, Serra-Baldrich E, Song Z, Soria A, Staevska M, Staubach P, Tagka A, Takahagi S, Francis Thomsen S, Treudler R, Vadasz Z, Oliveira Rodrigues Valle S, Van Doorn M B A, Vestergaard C, Wagner N, Wang D, Wang L, Wedi B, Xepapadaki P, Yucel E, Zalewska-Janowska A, Zhao Z, Zuberbier T, Maurer M. The global impact of the COVID-19 pandemic on the management and course of chronic urticaria. Allergy. 2020 Dec 7. Online ahead of print. DOI: 10.1111/all.14687 Hanke A A, Sundermeier T, Boeck H T, Schieffer E, Boyen J, Braun A C, Rolff S, Stein L, Kuck M, Schiffer M, Pape L, de Zwaan M, Haufe S, Kerling A, Tegtbur U, Nohre M. Influence of Officially Ordered Restrictions During the First Wave of COVID-19 Pandemic on Physical Activity and Quality of Life in Patients after Kidney Transplantation in a Telemedicine Based Aftercare Program-A KTx360° Sub Study. Int J Environ Res Public Health 2020 Dec 7;17(23):9144 DOI: 10.3390/ijerph17239144 Worm M, Ballmer-Weber B, Brehler R, Cuevas M, Gschwend A, Hartmann K, Hawranek T, Hotzenecker W, Homey B, Jakob T, Novak N, Pickert J, Saloga J, Schakel K, Trautmann A, Treudler R, Wedi B, Sturm G, Rueff F. Healthcare provision for insect venom allergy patients during the COVID-19 pandemic. Allergo J Int. 2020 Dec 8;1-5 DOI: 10.1007/s40629-020-00157-z Mohn N, Konen F F, Pul R, Kleinschnitz C, Pruss H, Witte T, Stangel M, Skripuletz T. Experience in Multiple Sclerosis Patients with COVID-19 and Disease-Modifying Therapies: A Review of 873 Published Cases. J Clin Med 2020 Dec 16;9(12) DOI: 10.3390/jcm9124067 Moritz R K C, Gutzmer R, Zimmer L, Meier F, Ahmed M S, Sell S, Schlaak M, Kapp F, Sachse M M, Haferkamp S, Welzel J, Kahler K C, Weichenthal M. SARS-CoV-2 infections in melanoma patients treated with PD-1 inhibitors: A survey of the German ADOREG melanoma registry. Eur J Cancer 2021 Feb;144:382-385 DOI: 10.1016/j.ejca.2020.11.015 Worm M, Ballmer-Weber B, Brehler R, Cuevas M, Gschwend A, Hartmann K, Hawranek T, Hotzenecker W, Homey B, Jakob T, Novak N, Pickert J, Saloga J, Schakel K, Trautmann A, Treudler R, Wedi B, Sturm G, Rueff F. Versorgungssituation von Insektengiftallergikern während der COVID-19-Pandemie. Allergo J 2020;29(8):16-21 DOI: 10.1007/s15007-020-2646-7 Cordes A K, Rehrauer W M, Accola M A, Wolk B, Hilfrich B, Heim A. Fully automated detection and differentiation of pandemic and endemic coronaviruses (NL63, 229E, HKU1, OC43 and SARS-CoV-2) on the Hologic Panther Fusion. J Med Virol 2020 Dec 22 DOI: 10.1002/jmv.26749 Mikuteit M, Steffens S, Grigull L, Kuhnle L, Behrends M, Schmidt R, Mucke U. Rapid development of a digital module during the Covid 19 pandemic in undergraduate medical education of pediatrics by teachers and students. GMS J Med Educ 2020 Dec 3;37(7) DOI: 10.3205/zma001359 von Lengerke T, Afshar K, Just I, Lange K. Classroom teaching with simulated patients during COVID-19: the communication skills course in the second year of the model medical curriculum HannibaL. GMS J Med Educ 2020 Dec 3 DOI: 10.3205/zma001374 Behrends M, Hoffmann I, Marschollek M, HiGHmeducation Consortium Teamwork, communication and exchange despite Covid-19 - experiences from a digital elective in human medicine studies as part of the HiGHmed project. GMS J Med Educ 2020 Dec 3 DOI: 10.3205/zma001379 Lotta G, Kuhlmann E. When informal work and poor work conditions backfire and fuel the COVID-19 pandemic: Why we should listen to the lessons from Latin America. Int J Health Plann Manage 2020 Dec 24 DOI: 10.1002/hpm.3104 Publications with the PMID: 33375139 - 34196842 Lemenager T, Neissner M, Koopmann A, Reinhard I, Georgiadou E, Muller A, Kiefer F, Hillemacher T. COVID-19 Lockdown Restrictions and Online Media Consumption in Germany Int J Environ Res Public Health 2020 Dec 22 DOI: 10.3390/ijerph18010014 Schieffer E, Schieffer B, Hilfiker-Kleiner D. [Cardiovascular diseases and COVID-19 : Pathophysiology, complications and treatment] Herz 2021 Jan 4;1-8 DOI: 10.1007/s00059-020-05013-y Hofman P, Ilie M, Chamorey E, Brest P, Schiappa R, Nakache V, Antoine M, Barberis M, Begueret H, Bibeau F, Bonnetaud C, Bostrom P, Brousset P, Bubendorf L, Carvalho L, Cathomas G, Cazes A, Chalabreysse L, Chenard M P, Copin M C, Cote J F, Damotte D, de Leval L, Delongova P, Thomas de Montpreville V, de Muret A, Dema A, Dietmaier W, Evert M, Fabre A, Forest F, Foulet A, Garcia S, Garcia-Martos M, Gibault L, Gorkiewicz G, Jonigk D, Gosney J, Hofman A, Kern I, Kerr K, Kossai M, Kriegsmann M, Lassalle S, Long-Mira E, Lupo A, Mamilos A, Matej R, Meilleroux J, Ortiz-Villalon C, Panico L, Panizo A, Papotti M, Pauwels P, Pelosi G, Penault-Llorca F, Pop O, Pote N, Cajal S R Y, Sabourin J C, Salmon I, Sajin M, Savic-Prince S, Schildhaus H U, Schirmacher P, Serre I, Shaw E, Sizaret D, Stenzinger A, Stojsic J, Thunnissen E, Timens W, Troncone G, Werlein C, Wolff H, Berthet J P, Benzaquen J, Marquette C H, Hofman V, Calabrese F. Clinical and molecular practice of European thoracic pathology laboratories during the COVID-19 pandemic. The past and the near future ESMO Open 2020 Dec 2;6(1) DOI: 10.1016/j.esmoop.2020.100024 Bockers A, Claassen H, Haastert-Talini K, Westermann J. Teaching anatomy under COVID-19 conditions at German universities: recommendations of the teaching commission of the anatomical society. Ann Anat 2021 Mar;234:151669 DOI: 10.1016/j.aanat.2020.151669 Pabst A, Zeller A N, Sader,R.;Wiegner,J. U.;Schneider,M.;Ehrenfeld,M.;Hoffmann,J. The influence of the SARS-CoV-2 pandemic on oral and maxillofacial surgery: a nationwide survey among 54 hospitals and 240 private practices in Germany Clin Oral Investig 2021 Jan 6 DOI: 10.1007/s00784-020-03715-5 Vinson A J, Chong A S, Clegg D, Falk C, Foster B J, Halpin A, Mannon R B, Palmer B F, Oertelt-Prigione S, West L J, Wong G, Sapir-Pichhadze R. Sex Matters - Covid-19 in Kidney Transplantation Kidney Int 2021 Jan 5 DOI: 10.1016/j.kint.2020.12.020 Garg A, Seeliger B, Derda A A, Xiao K, Gietz A, Scherf K, Sonnenschein K, Pink I, Hoeper M M, Welte T, Bauersachs J, David S, Bar C, Thum T. Circulating cardiovascular microRNAs in critically ill COVID-19 patients Short title: microRNA signatures in COVID-19 Eur J Heart Fail 2021 Jan 9 DOI: 10.1002/ejhf.2096 Jappe U, Beckert H, Bergmann K C, Gulsen A, Klimek L, Philipp S, Pickert J, Rauber-Ellinghaus M M, Renz H, Taube C, Treudler R, Wagenmann M, Werfel T, Worm M, Zuberbier T. Biologics for atopic diseases: Indication, side effect management, and new developments Allergol Select 2021 Jan 5 DOI: 10.5414/ALX02197E Kleine-Tebbe J, Klimek L, Hamelmann E, Pfaar O, Taube C, Wagenmann M, Werfel T, Worm M. Severe allergic reactions to the COVID-19 vaccine - statement and practical consequences. Allergol Select 2021;5:26-28 DOI: 10.5414/ALX02215E Rohr S, Zulke A, Luppa M, Brettschneider C, Weissenborn M, Kuhne F, Zollinger I, Samos FZ, Bauer A, Dohring J, Krebs-Hein K, Oey A, Czock D, Frese T, Gensichen J, Haefeli WE, Hoffmann W, Kaduszkiewicz H, Konig HH, Thyrian JR, Wiese B, Riedel-Heller SG. Recruitment and Baseline Characteristics of Participants in the AgeWell.de Study-A Pragmatic Cluster-Randomized Controlled Lifestyle Trial against Cognitive Decline. Int J Environ Res Public Health 2021;18(2):10.3390/ijerph18020408 DOI: E408 Worm M, Ring J, Klimek L, Jakob T, Lange L, Treudler R, Beyer K, Werfel T, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller AR, Hoffmann F, Huttegger I, Kopp MV, Kugler C, Lommatzsch M, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stocker B, Vogelberg C, Sitter H, Gieler U, Brockow K. Covid-19 vaccination and risk of anaphylaxis - Recommendations for practical management. MMW Fortschr Med 2021;163(1):48-51 DOI: 10.1007/s15006-021-9530-6 Jangra S, De Vrieze J, Choi A, Rathnasinghe R, Laghlali G, Uvyn A, Van Herck S, Nuhn L, Deswarte K, Zhong Z, Sanders N, Lienenklaus S, David S, Strohmeier S, Amanat F, Krammer F, Hammad H, Lambrecht BN, Coughlan L, Garcia-Sastre A, de Geest B, Schotsaert M. Sterilizing Immunity against SARS-CoV-2 Infection in Mice by a Single-Shot and Lipid Amphiphile Imidazoquinoline TLR7/8 Agonist-Adjuvanted Recombinant Spike Protein Vaccine. Angew Chem Int Ed Engl 2021 DOI: 10.1002/anie.202015362 Lander J, Curbach J, von Sommoggy J, Bitzer EM, Dierks ML. Awareness, Information-Seeking Behavior, and Information Preferences About Early Childhood Allergy Prevention Among Different Parent Groups: Protocol for a Mixed Methods Study. JMIR Res Protoc 2021;10(1):e25474 DOI: 10.2196/25474 Stover T, Dazert S, Plontke SK, Kramer S, Ambrosch P, Arens C, Betz C, Beutner D, Bohr C, Bruchhage KL, Canis M, Dietz A, Guntinas-Lichius O, Hagen R, Hosemann W, Iro H, Klussmann JP, Knopf A, Lang S, Leinung M, Lenarz T, Lowenheim H, Matthias C, Mlynski R, Olze H, Park J, Plinkert P, Radeloff A, Rotter N, Rudack C, Bozzato A, Schipper J, Schrader M, Schuler PJ, Strieth S, Stuck BA, Volkenstein S, Westhofen M, Wolf G, Wollenberg B, Zahnert T, Zenk J, Hoffmann TK. Effects of the SARS-CoV2 pandemic on the otolaryngology university hospitals in the field of research, student teaching and specialist training. HNO 2021 DOI: 10.1007/s00106-021-01001-8 Khailaie S, Mitra T, Bandyopadhyay A, Schips M, Mascheroni P, Vanella P, Lange B, Binder SC, Meyer-Hermann M. Development of the reproduction number from coronavirus SARS-CoV-2 case data in Germany and implications for political measures. BMC Med 2021;19(1):32-020-01884-4 DOI: 10.1186/s12916-020-01884-4 Worm M, Bauer A, Wedi B, Treudler R, Pfuetzner W, Brockow K, Buhl T, Zuberbier T, Fluhr J, Wurpts G, Klimek L, Jacob T, Merk HF, Mulleneisen N, Roeseler S, Dickel H, Raap U, Kleine-Tebbe J. Practical recommendations for the allergological risk assessment of the COVID-19 vaccination - a harmonized statement of allergy centers in Germany. Allergol Select 2021;5:72-76 DOI: 10.5414/ALX02225E Schiffer L, Gertges R, Nohre M, Schieffer E, Tegtbur U, Pape L, de Zwaan M, Schiffer M. Use and preferences regarding internet-based health care delivery in patients with chronic kidney disease. BMC Med Inform Decis Mak 2021;21(1):34 DOI: 10.1186/s12911-020-01375-9 Ring J, Beyer K, Biedermann T, Bircher A, Fischer M, Fuchs T, Heller A, Hoffmann F, Huttegger I, Jakob T, Klimek L, Kopp MV, Kugler C, Lange L, Pfaar O, Rietschel E, Rueff F, Schnadt S, Seifert R, Stocker B, Treudler R, Vogelberg C, Werfel T, Worm M, Sitter H, Brockow K. Guideline (S2k) on acute therapy and management of anaphylaxis: 2021 update: S2k-Guideline of the German Society for Allergology and Clinical Immunology (DGAKI), the Medical Association of German Allergologists (AeDA), the Society of Pediatric Allergology and Environmental Medicine (GPA), the German Academy of Allergology and Environmental Medicine (DA the German Professional Association of Pediatricians (BVKJ), the Society for Neonatology and Pediatric Intensive Care (GNPI), the German Society of Dermatology (DDG), the Austrian Society for Allergology and Immunology (OGAI), the Swiss Society for Allergy and Immunology (SGAI), the German Society of Anaesthesiology and Intensive Care Medicine (DGAI), the German Society of Pharmacology (DGP), the German Respiratory Society (DGP), the patient organization German Allergy and Asthma Association (DAAB), the German Working Group of Anaphylaxis Training and Education (AGATE). Allergo J Int 2021:1-25 DOI: 10.1007/s40629-020-00158-y Seifert J, Meissner C, Birkenstock A, Bleich S, Toto S, Ihlefeld C, Zindler T. Peripandemic psychiatric emergencies: impact of the COVID-19 pandemic on patients according to diagnostic subgroup. Eur Arch Psychiatry Clin Neurosci 2021 DOI: 10.1007/s00406-020-01228-6 Ackermann M, Werlein C, Langer F, Kuhnel MP, Jonigk DD. COVID-19: effects on the lungs and heart. Pathologe 2021 DOI: 10.1007/s00292-021-00918-9 Cornberg M, Buti M, Eberhardt CS, Grossi PA, Shouval D. EASL position paper on the use of COVID-19 vaccines in patients with chronic liver diseases, hepatobiliary cancer and liver transplant recipients. J Hepatol 2021 DOI: S0168-8278(21)00081-7 Bonifacius A, Tischer-Zimmermann S, Dragon AC, Gussarow D, Vogel A, Krettek U, Godecke N, Yilmaz M, Kraft ARM, Hoeper MM, Pink I, Schmidt JJ, Li Y, Welte T, Maecker-Kolhoff B, Martens J, Berger MM, Lobenwein C, Stankov MV, Cornberg M, David S, Behrens GMN, Witzke O, Blasczyk R, Eiz-Vesper B. COVID-19 immune signatures reveal stable antiviral T cell function despite declining humoral responses. Immunity 2021 DOI: S1074-7613(21)00031-5 Dowsett M, Ellis MJ, Dixon JM, Gluz O, Robertson J, Kates R, Suman VJ, Turnbull AK, Nitz U, Christgen M, Kreipe H, Kuemmel S, Bliss JM, Barry P, Johnston SR, Jacobs SA, Ma CX, Smith IE, Harbeck N. Evidence-based guidelines for managing patients with primary ER+ HER2- breast cancer deferred from surgery due to the COVID-19 pandemic. NPJ Breast Cancer 2020;6(1):21-020-0168-9 DOI: 10.1038/s41523-020-0168-9 Thyssen JP, Vestergaard C, Barbarot S, de Bruin-Weller MS, Bieber T, Taieb A, Seneschal J, Cork MJ, Paul C, Flohr C, Weidinger S, Trzeciak M, Werfel T, Heratizadeh A, Darsow U, Simon D, Torrelo A, Chernyshov PV, Stalder JF, Gelmetti C, Szalai Z, Svensson A, von Kobyletzki LB, De Raeve L, Folster-Holst R, Christen-Zaech S, Jan Hijnen D, Gieler U, Gutermuth J, Bangert C, Spuls PI, Kunz B, Ring J, Wollenberg A, Deleuran M. European Task Force on Atopic Dermatitis (ETFAD): position on vaccination of adult patients with atopic dermatitis against COVID-19 (SARS-CoV-2) being treated with systemic medication and biologics. J Eur Acad Dermatol Venereol 2021 DOI: 10.1111/jdv.17167 von Stillfried S, Acker T, Aepfelbacher M, Baretton G, Bulow RD, Burrig KF, Holtherm HU, Jonigk D, Knuchel R, Majeed RW, Rohrig R, Wienstroer J, Boor P. Kooperatives Vorgehen der Pathologie und Neuropathologie in der COVID-19-Pandemie : Deutsches Register fur COVID-19-Obduktionen (DeRegCOVID) und Deutsches Netzwerk fur Autopsien in Pandemien (DEFEAT PANDEMIcs). Pathologe 2021 DOI: 10.1007/s00292-020-00891-9 Lasch F, Guizzaro L, Aguirre Davila L, Muller-Vahl K, Koch A. Potential impact of COVID-19 on ongoing clinical trials: a simulation study with the neurological Yale Global Tic Severity Scale based on the CANNA-TICS study. Pharm Stat 2021 DOI: 10.1002/pst.2100 Czabanowska K, Kuhlmann E. Public health competences through the lens of the COVID-19 pandemic: what matters for health workforce preparedness for global health emergencies. Int J Health Plann Manage 2021 DOI: 10.1002/hpm.3131 Becker M, Strengert M, Junker D, Kaiser PD, Kerrinnes T, Traenkle B, Dinter H, Haring J, Ghozzi S, Zeck A, Weise F, Peter A, Horber S, Fink S, Ruoff F, Dulovic A, Bakchoul T, Baillot A, Lohse S, Cornberg M, Illig T, Gottlieb J, Smola S, Karch A, Berger K, Rammensee HG, Schenke-Layland K, Nelde A, Marklin M, Heitmann JS, Walz JS, Templin M, Joos TO, Rothbauer U, Krause G, Schneiderhan-Marra N. Exploring beyond clinical routine SARS-CoV-2 serology using MultiCoV-Ab to evaluate endemic coronavirus cross-reactivity. Nat Commun 2021;12(1):1152-021-20973-3 DOI: 10.1038/s41467-021-20973-3 Kruck D. Original-/übers. Titel: Studieren in Zeiten von Covid-19 - Chancen und Herausforderungen Biospektrum (Heidelb) 2021;27(1):3-021-1532-6.Epub 2021 Feb 12 DOI: 10.1007/s12268-021-1532-6 Huber MK, Raichle C, Synofzik M, Borgmann S, Erber J, Tometten L, Rimili W, Dolff S, Wille K, Knauss S, Piepel C, Lanznaster J, Rieg S, Prasser F, Pilgram L, Spottke A, Klockgether T, Klein C, Hopfner F, Hoglinger GU, LEOSS Study Group. Outcomes of SARS-CoV-2 Infections in Patients With Neurodegenerative Diseases in the LEOSS Cohort. Mov Disord 2021 DOI: 10.1002/mds.28554 Ghaneirad E, Groba S, Bleich S, Szycik GR. Nutzung der ambulanten Psychotherapie über die Videosprechstunde: Ein Drittel der Patienten wird nicht erreicht. [Use of outpatient psychotherapy via video consultation] Psychotherapeut (Berl) 2021:1-6 DOI: 10.1007/s00278-021-00497-3 Klimek L, Novak N, Hamelmann E, Werfel T, Wagenmann M, Taube C, Bauer A, Merk H, Rabe U, Jung K, Schlenter W, Ring J, Chaker A, Wehrmann W, Becker S, Mulleneisen N, Nemat K, Czech W, Wrede H, Brehler R, Fuchs T, Jakob T, Ankermann T, Schmidt SM, Gerstlauer M, Vogelberg C, Zuberbier T, Hartmann K, Worm M. Severe allergic reactions after COVID-19 vaccination with the Pfizer/BioNTech vaccine in Great Britain and USA: Position statement of the German Allergy Societies: Medical Association of German Allergologists (AeDA), German Society for Allergology and Clinical Immunology (DGAKI) and Society for Pediatric Allergology and Environmental Medicine (GPA). Allergo J Int 2021: 1-5 DOI: 10.1007/s40629-020-00160-4 Bauer A, Dickel H, Jakob T, Kleinheinz A, Lippert U, Metz M, Schliemann S, Schwichtenberg U, Staubach P, Valesky E, Wagner N, Wedi B, Maurer M. Expert consensus on practical aspects in the treatment of chronic urticaria. Allergo J Int 2021:1-12 DOI: 10.1007/s40629-021-00162-w Skripuletz T, Mohn N, Franke C, Pruss H. Neuroimmunologie von COVID-19 [Neuroimmunology of COVID-19]. Nervenarzt 2021 DOI: 10.1007/s00115-021-01077-1 Muus C, Luecken MD, Eraslan G, Sikkema L, Waghray A, Heimberg G, Kobayashi Y, Vaishnav ED, Subramanian A, Smillie C, Jagadeesh KA, Duong ET, Fiskin E, Triglia ET, Ansari M, Cai P, Lin B, Buchanan J, Chen S, Shu J, Haber AL, Chung H, Montoro DT, Adams T, Aliee H, Allon SJ, Andrusivova Z, Angelidis I, Ashenberg O, Bassler K, Becavin C, Benhar I, Bergenstrahle J, Bergenstrahle L, Bolt L, Braun E, Bui LT, Callori S, Chaffin M, Chichelnitskiy E, Chiou J, Conlon TM, Cuoco MS, Cuomo ASE, Deprez M, Duclos G, Fine D, Fischer DS, Ghazanfar S, Gillich A, Giotti B, Gould J, Guo M, Gutierrez AJ, Habermann AC, Harvey T, He P, Hou X, Hu L, Hu Y, Jaiswal A, Ji L, Jiang P, Kapellos TS, Kuo CS, Larsson L, Leney-Greene MA, Lim K, Litvinukova M, Ludwig LS, Lukassen S, Luo W, Maatz H, Madissoon E, Mamanova L, Manakongtreecheep K, Leroy S, Mayr CH, Mbano IM, McAdams AM, Nabhan AN, Nyquist SK, Penland L, Poirion OB, Poli S, Qi C, Queen R, Reichart D, Rosas I, Schupp JC, Shea CV, Shi X, Sinha R, Sit RV, Slowikowski K, Slyper M, Smith NP, Sountoulidis A, Strunz M, Sullivan TB, Sun D, Talavera-Lopez C, Tan P, Tantivit J, Travaglini KJ, Tucker NR, Vernon KA, Wadsworth MH, Waldman J, Wang X, Xu K, Yan W, Zhao W, Ziegler CGK, NHLBI LungMap Consortium, Human Cell Atlas Lung Biological Network. Single-cell meta-analysis of SARS-CoV-2 entry genes across tissues and demographics. Nat Med 2021 DOI: 10.1038/s41591-020-01227-z Giesen N, Sprute R, Ruthrich M, Khodamoradi Y, Mellinghoff SC, Beutel G, Lueck C, Koldehoff M, Hentrich M, Sandherr M, von Bergwelt-Baildon M, Wolf HH, Hirsch HH, Wormann B, Cornely OA, Kohler P, Schalk E, von Lilienfeld-Toal M, COVID-19 guideline panel of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO). 2021 update of the AGIHO guideline on evidence-based management of COVID-19 in patients with cancer regarding diagnostics, viral shedding, vaccination and therapy. Eur J Cancer 2021;147:154-160 DOI: 10.1016/j.ejca.2021.01.033 Karagiannidis C, Windisch W, McAuley DF, Welte T, Busse R. Major differences in ICU admissions during the first and second COVID-19 wave in Germany. Lancet Respir Med 2021 DOI: 10.1016/S2213-2600(21)00101-6 Chalmers JD, Crichton ML, Goeminne PC, Cao B, Humbert M, Shteinberg M, Antoniou KM, Ulrik CS, Parks H, Wang C, Vandendriessche T, Qu J, Stolz D, Brightling C, Welte T, Aliberti S, Simonds AK, Tonia T, Roche N. Management of hospitalised adults with coronavirus disease-19 (COVID-19): A European Respiratory Society living guideline. Eur Respir J 2021 DOI: 10.1183/13993003.00048-2021 Kreitlow A, Steffens S, Jablonka A, Kuhlmann E. Support for global health and pandemic preparedness in medical education in Germany: Students as change agents. Int J Health Plann Manage 2021 DOI: 10.1002/hpm.3143 Orgel M, Gogol M, Graulich T, Omar M, Ranker A, Bottcher C, Liodakis E, Krettek C, Macke C. A. Retrospective Analysis of the Initial Effect of COVID-19 on German Prehospital Care During Lockdown in Germany. Open Access Emerg Med 2021;13:97-105 DOI: 10.2147/OAEM.S289070 von Stillfried S, Acker T, Aepfelbacher M, Baretton G, Bulow RD, Burrig KF, Holtherm HU, Jonigk D, Knuchel R, Majeed RW, Rohrig R, Wienstroer J, Boor P. Cooperative approach of pathology and neuropathology in the COVID-19 pandemic : German registry for COVID-19 autopsies (DeRegCOVID) and German network for autopsies in pandemics (DEFEAT PANDEMIcs). Pathologe 2021 DOI: 10.1007/s00292-020-00897-3 Fink S, Ruoff F, Stahl A, Becker M, Kaiser P, Traenkle B, Junker D, Weise F, Ruetalo N, Horber S, Peter A, Nelde A, Walz J, Krause G, Baillot A, Schenke-Layland K, Joos TO, Rothbauer U, Schneiderhan-Marra N, Schindler M, Templin MF. Multiplexed Serum Antibody Screening Platform Using Virus Extracts from Endemic Coronaviridae and SARS-CoV-2. ACS Infect Dis 2021 DOI: 10.1021/acsinfecdis.0c00725 Nasa P, Azoulay E, Khanna AK, Jain R, Gupta S, Javeri Y, Juneja D, Rangappa P, Sundararajan K, Alhazzani W, Antonelli M, Arabi YM, Bakker J, Brochard LJ, Deane AM, Du B, Einav S, Esteban A, Gajic O, Galvagno SM,Jr, Guerin C, Jaber S, Khilnani GC, Koh Y, Lascarrou JB, Machado FR, Malbrain MLNG, Mancebo J, McCurdy MT, McGrath BA, Mehta S, Mekontso-Dessap A, Mer M, Nurok M, Park PK, Pelosi P, Peter JV, Phua J, Pilcher DV, Piquilloud L, Schellongowski P, Schultz MJ, Shankar-Hari M, Singh S, Sorbello M, Tiruvoipati R, Udy AA, Welte T, Myatra SN. Expert consensus statements for the management of COVID-19-related acute respiratory failure using a Delphi method. Crit Care 2021;25(1):106 DOI: 10.1186/s13054-021-03491-y Welte T, Ambrose LJ, Sibbring GC, Sheikh S, Müllerová H, Sabir I. Current evidence for COVID-19 therapies: a systematic literature review. Respir Rev 2021;30(159):200384 DOI: 10.1183/16000617.0384 Ring J, Worm M, Wollenberg A, Thyssen JP, Jakob T, Klimek L, Bangert C, Barbarot S, Bieber T, de Bruin-Weller MS, Chernyshov PV, Christen-Zaech S, Cork M, Darsow U, Flohr C, Folster-Holst R, Gelmetti C, Gieler U, Gutermuth J, Heratizadeh A, Hijnen DJ, von Kobyletzki LB, Kunz B, Paul C, De R, Seneschal J, Simon D, Spuls PI, Stalder JF, Svensson A, Szalai Z, Taieb A, Torrelo A, Trzeciak M, Vestergaard, Werfel T, Weidinger S, Deleuran M. Risk of severe allergic reactions to COVID-19 vaccines among patients with allergic skin diseases - practical recommendations. A position statement of ETFAD with external experts. J Eur Acad Dermatol Venereol 2021 DOI: 10.1111/jdv.17237 Wieting J, Eberlein C, Bleich S, Frieling H, Deest M. Behavioural change in Prader-Willi syndrome during COVID-19 pandemic. J Intellect Disabil Res 2021 DOI: 10.1111/jir.12831 Ivanyi P, Park-Simon T, Christiansen H, Gutzmer R, Vogel A, Heuser M, Golpon H, Hillemanns P, Haier J. Protective measures for patients with advanced cancer during the Sars-CoV-2 pandemic: Quo vadis? Clin Exp Metastasis 2021 DOI: 10.1007/s10585-021-10083-1 Klimek L, Novak N, Hamelmann E., Werfel T, Wagenmann M, Taube C, Bauer A, Merk HF, Rabe U, Jung K, Schlenter WW, Ring J, Chaker AM, Wehrmann W, Becker S, Mulleneisen NK, Nemat K, Czech W, Wrede H, Brehler R, Fuchs T, Jakob T, Ankermann T, Schmidt SM, Gerstlauer M, Vogelberg C, Zuberbier T, Hartmann K, Worm M. Schwere allergische Reaktionen nach COVID-19-Impfung mit dem Impfstoff von Pfizer/BioNTech in Grossbritannien und USA: Stellungnahme der deutschen allergologischen Gesellschaften AeDA (Arzteverband Deutscher Allergologen), DGAKI (Deutsche Gesellschaft fur Allergologie und klinische Immunologie) und GPA (Gesellschaft fur Padiatrische Allergologie und Umweltmedizin). Allergo J 2021;30(2):24-29 DOI: 10.1007/s15007-021-4762-4 Kos I, Balensiefer B, Lesan V, Kaddu-Mulindwa D, Thurner L, Christofyllakis K, Bittenbring JT, Ahlgrimm M, Seiffert M, Wagenpfeil S, Bewarder Y, Neumann F, Rixecker T, Smola S, Link A, Krawczyk M, Lammert F, Lepper PM, Bals R, Stilgenbauer S, Bewarder M. Increased B Cell activity with consumption of activated monocytes in severe COVID-19 patients. Eur J Immunol 2021 DOI: 10.1002/eji.202049163 Gawalko M, Duncker D, Manninger M, van der Velden RMJ, Hermans ANL, Verhaert DVM, Pison L, Pisters R, Hemels M, Sultan A, Steven D, Gupta D, Heidbuchel H, Sohaib A, Wijtvliet P, Tieleman R, Gruwez H, Chun J, Schmidt B, Keaney JJ, Muller P, Lodzinski P, Svennberg E, Hoekstra O, Jansen WPJ, Desteghe L, de Potter T, Tomlinson DR, Neubeck L, Crijns HJGM, Pluymaekers NAHA, Hendriks JM, Linz D. The European TeleCheck-AF project on remote app-based management of atrial fibrillation during the COVID-19 pandemic: centre and patient experiences. Europace 2021 DOI: 10.1093/europace/euab050 Natanov R, Wiesner O, Haverich A, Kuhn C. Mechanical circulatory support in coronavirus disease-2019-positive patients with severe respiratory failure. Interact Cardiovasc Thorac Surg 2021 DOI: 10.1093/icvts/ivab087 Badimon L, Robinson EL, Jusic A, Carpusca I, de Windt LJ, Emanueli C, Ferdinandy P, Gu W, Gyongyosi M, Hackl M, Karaduzovic-Hadziabdic K, Lustrek M, Martelli F, Nham E, Potocnjak I, Satagopam V, Schneider R, Thum T, Devaux Y, EU-CardioRNA COST Action CA17129. Cardiovascular rna markers and artificial intelligence may improve covid-19 outcome: position paper from the eu-cardiorna cost action ca17129. Cardiovasc Res 2021 DOI: 10.1093/cvr/cvab094 Schultz B, Krauss T, Schmidt M, Schultz M, Schneider A, Wiesner O, Schmidt JJ, Stahl K, David S, Hoeper MM, Busch M. High High Incidence of Epileptiform Potentials During Continuous EEG Monitoring in Critically Ill COVID-19 Patients. Front Med (Lausanne) 2021;8:613951 DOI: 10.3389/fmed.2021.613951 Pfaar O, Klimek L, Hamelmann E, Kleine-Tebbe J, Taube C, Wagenmann M, Werfel T, Brehler R, Novak N, Mulleneisen N, Becker S, Worm M. COVID-19 vaccination of patients with allergies and type-2 inflammation with concurrent antibody therapy (biologicals) - A Position Paper of the German Society of Allergology and Clinical Immunology (DGAKI) and the German Society for Applied Allergology (AeDA). Allergol Select 2021;5:140-147 DOI: 10.5414/ALX02241E Tacke F, Cornberg M, Sterneck M, Trebicka J, Settmacher U, Bechstein WO, Berg T, Deutsche Gesellschaft fur Gastroenterologie, Verdauungs- und Stoffwechselkrankheiten (DGVS), vertreten durch Frank Tacke, Markus Cornberg, Martina Sterneck, Jonel Trebicka, Thomas Berg, Deutsche Gesellschaft fur Allgemein- und Viszeralchirurgie (DGAV), vertreten durch Wolf Bechstein, Deutsche Transplantationsgesellschaft (DTG), vertreten durch Utz Settmacher, Die Leitlinie wird von der Deutschen Gesellschaft fur Pneumologie (DGP) unterstutzt. S1-Leitlinie zur Versorgung von Lebertransplantierten wahrend der COVID-19-Pandemie - AWMF-Register Nr. 021-031 - Stand: 07.01.21 Z Gastroenterol 2021;59(4):345-359 DOI: 10.1055/a-1372-5595 Windisch W, Kluge S, Bachmann M, Criee CP, Weber-Carstens S, Westhoff M, Karagiannidis C, Welte T. Conservative management of COVID-19 associated hypoxaemia. ERJ Open Res 2021;7(2):10.1183/23120541.00113-2021. eCollection 2021 Apr DOI: 10.1183/23120541.00113-2021 Georgiadou E, Koopmann A, Muller A, Lemenager T, Hillemacher T, Kiefer F. Who Was Shopping More During the Spring Lockdown 2020 in Germany? Front Psychiatry 2021;12:650989 DOI: 10.3389/fpsyt.2021.650989 Pfrepper C, Holstein K, Konigs C, Heller C, Krause M, Olivieri M, Bidlingmaier C, Sigl-Kraetzig M, Wendisch J, Halimeh S, Horneff S, Richter H, Wieland I, Klamroth R, Oldenburg J, Tiede A, Hemophilia Board of the German, Austrian, Swiss Society on Thrombosis Hemostasis Research (GTH). Consensus Recommendations for Intramuscular COVID-19 Vaccination in Patients with Hemophilia. Hamostaseologie 2021 DOI: 10.1055/a-1401-2691 Framme C, Gottschling J, Buley P, Rohwer-Mensching K, Junker B, Dittberner M, Volkmann I. Influence of COVID-19 shutdown on the workload of a university eye clinic. Ophthalmologe 2021 DOI: 10.1007/s00347-021-01374-9 Gutenbrunner C, Nugraha B, Martin LT. Phase-adapted Rehabilitation for acute corona virus disease-19 (COVID-19) patients and patient with long-term sequelae of COVID-19. Am J Phys Med Rehabil 2021 DOI: 10.1097/PHM.0000000000001762 Koopmann A, Georgiadou E, Reinhard I, Muller A, Lemenager T, Kiefer F, Hillemacher T. The Effects of the Lockdown during the COVID-19 Pandemic on Alcohol and Tobacco Consumption Behavior in Germany. Eur Addict Res 2021:1-15 DOI: 10.1159/000515438 [doi] Muller F, Hummers E, Jablonka A, Schmidt T, Noack EM. Impact of the COVID-19 lockdown on emergency medical service operations. Notf Rett Med 2021:1-6 DOI: 10.1007/s10049-021-00873-1 Wagner TR, Ostertag E, Kaiser PD, Gramlich M, Ruetalo N, Junker D, Haering J, Traenkle B, Becker M, Dulovic A, Schweizer H, Nueske S, Scholz A, Zeck A, Schenke-Layland K, Nelde A, Strengert M, Walz JS, Zocher G, Stehle T, Schindler M, Schneiderhan-Marra N, Rothbauer U. NeutrobodyPlex-monitoring SARS-CoV-2 neutralizing immune responses using nanobodies. EMBO Rep 2021:e52325 DOI: 10.15252/embr.202052325 Kanngiesser K, Kono N, Suhren JT, Klintschar M. Case report: death of a 2-year-old girl with postmortem diagnosis of a rare coronary artery vasculitis typical for Kawasaki syndrome. Rechtsmedizin (Berl) 2021:1-5 DOI: 10.1007/s00194-021-00482-9 Tiede A, Sachs UJ, Czwalinna A, Werwitzke S, Bikker R, Krauss JK, Donnerstag FG, Weissenborn K, Hoglinger GU, Maasoumy B, Wedemeyer H, Ganser A. Prothrombotic immune thrombocytopenia after COVID-19 vaccine. Blood 2021 DOI: 10.1182/blood.2021011958 Becker K, Beythien G, de Buhr N, Stanelle-Bertram S, Tuku B, Kouassi NM, Beck S, Zickler M, Allnoch L, Gabriel G, von Kockritz-Blickwede M, Baumgartner W. Vasculitis and Neutrophil Extracellular Traps in Lungs of Golden Syrian Hamsters With SARS-CoV-2. Front Immunol 2021;12:640842 DOI: 10.3389/fimmu.2021.640842 Birnhuber A, Fliesser E, Gorkiewicz G, Zacharias M, Seeliger B, David S, Welte T, Schmidt J, Olschewski H, Wygrecka M, Kwapiszewska G. Between inflammation and thrombosis - endothelial cells in COVID-19. Eur Respir J 2021 DOI: 10.1183/13993003.00377-2021 Wendt R, Thijs L, Kalbitz S, Mischak H, Siwy J, Raad J, Metzger J, Neuhaus B, Leyen HV, Dudoignon E, Mebazaa A, Spasovski G, Milenkova M, Canevska-Talevska A, Czerwienska B, Wiecek A, Peters B, Nilsson A, Schwab M, Rothfuss K, Lubbert C, Staessen JA, Beige J, CRIT-COV-U investigators. A urinary peptidomic profile predicts outcome in SARS-CoV-2-infected patients. EClinicalMedicine 2021:100883 DOI: 10.1016/j.eclinm.2021.100883 Thiele T, Beider S, Kuhl H, Mielke G, Holz A, Hirsch S, Witte T, Hoeper K, Cossmann A, Happle C, Jablonka A, Ernst D. Care of rheumatology patients during the lockdown in early 2020 : Telemedicine, delegation, patient satisfaction and vaccination behavior. Z Rheumatol 2021 DOI: 10.1007/s00393-021-01005-3 Fernandez-Luque L, Kushniruk AW, Georgiou A, Basu A, Petersen C, Ronquillo C, Paton C, Nohr C, Kuziemsky CE, Alhuwail D, Skiba D, Huesing E, Gabarron E, Borycki EM, Magrabi F, Denecke K, Peute LWP, Topaz M, Al-Shorbaji N, Lacroix P, Marcilly R, Cornet R, Gogia SB, Kobayashi S, Iyengar S, Deserno TM, Mettler T, Vimarlund V, Zhu X. Evidence-Based Health Informatics as the Foundation for the COVID-19 Response: A Joint Call for Action. Methods Inf Med 2021 DOI: 10.1055/s-0041-1726414 Enikeev D, Taratkin M, Efetov S, Shlomina A, Boldyreva M, Galkina I, Spivak L, Gitel E, Kuchieva A, Mikhailov V, Teoh JY, Herrmann TRW, Kikic Z, Fomin V, Shariat SF, Glybochko P. Acute kidney injury in COVID-19: are kidneys the target or just collateral damage? A comprehensive assessment of viral RNA and AKI rate in patients with COVID-19. Curr Opin Urol 2021 DOI: 10.1097/MOU.0000000000000901 Tsopra R, Frappe P, Streit S, Neves AL, Honkoop PJ, Espinosa-Gonzalez AB, Geroglu B, Jahr T, Lingner H, Nessler K, Pesolillo G, Sivertsen OS, Thulesius H, Zoitanu R, Burgun A, Kinouani S. Reorganisation of GP surgeries during the COVID-19 outbreak: analysis of guidelines from 15 countries. BMC Fam Pract 2021;22(1):96 DOI: 10.1186/s12875-021-01413-z Glaab T, Braun A. Noninvasive Measurement of Pulmonary Function in Experimental Mouse Models of Airway Disease. Lung 2021 DOI: 10.1007/s00408-021-00443-9 Pink I, Raupach D, Fuge J, Vonberg RP, Hoeper MM, Welte T, Rademacher J. C-reactive protein and procalcitonin for antimicrobial stewardship in COVID-19. Infection 2021 DOI: 10.1007/s15010-021-01615-8 Brüggenjürgen B, Stricker HP, Krist L, Ortiz M, Reinhold T, Roll S, Rotter G, Weikert B, Wiese-Posselt M, Willich SN. Impact of public health interventions to curb SARS-CoV-2 spread assessed by an evidence-educated Delphi panel and tailored SEIR model. Z Gesundh Wiss 2021:1-14 DOI: 10.1007/s10389-021-01566-2 Pfaar O, Bergmann KC, Bonini S, Compalati E, Domis N, de Blay F, de Kam PJ, Devillier P, Durham SR, Ellis AK, Gherasim A, Haya L, Hohlfeld JM, Horak F, Iinuma T, Jacobs RL, Jacobi HH, Jutel M, Kaul S, Kelly S, Klimek L, Larche M, Lemell P, Mahler V, Nolte H, Okamoto Y, Patel P, Rabin RL, Rather C, Sager A, Salapatek A, Sigsgaard T, Togias A, Willers C, Yang J, Zieglmayer R, Zuberbier T, Zieglmayer P. Technical standards in allergen exposure chambers worldwide - an EAACI Task Force Report. Allergy 2021 DOI: 10.1111/all.14957 Weber JP, Tielker JM, Kamandi N, Simon ST, Bausewein C, Stiel S, Schneider N. Outpatient care of oncological patients in palliative treatment situations and their relatives during the COVID-19 pandemic. Onkologe (Berl) 2021:1-7 DOI: 10.1007/s00761-021-00974-z Wendel Garcia PD, Aguirre-Bermeo H, Buehler PK, Alfaro-Farias M, Yuen B, David S, Tschoellitsch T, Wengenmayer T, Korsos A, Fogagnolo A, Kleger GR, Wu MA, Colombo R, Turrini F, Potalivo A, Rezoagli E, Rodriguez-Garcia R, Castro P, Lander-Azcona A, Martin-Delgado MC, Lozano-Gomez H, Ensner R, Michot MP, Gehring N, Schott P, Siegemund M, Merki L, Wiegand J, Jeitziner MM, Laube M, Salomon P, Hillgaertner F, Dullenkopf A, Ksouri H, Cereghetti S, Grazioli S, Burkle C, Marrel J, Fleisch I, Perez MH, Baltussen Weber A, Ceruti S, Marquardt K, Hubner T, Redecker H, Studhalter M, Stephan M, Selz D, Pietsch U, Ristic A, Heise A, Meyer Zu Bentrup F, Franchitti Laurent M, Fodor P, Gaspert T, Haberthuer C, Colak E, Heuberger DM, Fumeaux T, Montomoli J, Guerci P, Schuepbach RA, Hilty MP, Roche-Campo F, RISC-19-ICU Investigators. Implications of early respiratory support strategies on disease progression in critical COVID-19: a matched subanalysis of the prospective RISC-19-ICU cohort. Crit Care 2021;25(1):175 DOI: 10.1186/s13054-021-03580-y Becker M, Dulovic A, Junker D, Ruetalo N, Kaiser PD, Pinilla YT, Heinzel C, Haering J, Traenkle B, Wagner TR, Layer M, Mehrlaender M, Mirakaj V, Held J, Planatscher H, Schenke-Layland K, Krause G, Strengert M, Bakchoul T, Althaus K, Fendel R, Kreidenweiss A, Koeppen M, Rothbauer U, Schindler M, Schneiderhan-Marra N. Immune response to SARS-CoV-2 variants of concern in vaccinated individuals. Nat Commun 2021;12(1):3109 DOI: 10.1038/s41467-021-23473-6 Stahl K, Seeliger B, Hofmaenner DA, Doebler M, Bode C, David S. The Janus Face of Coronavirus Disease 2019-Associated Coagulopathy. Crit Care Med 2021 DOI: 10.1097/CCM.0000000000005128 Cornberg M, Eberhardt CS. Protected or not protected, that is the question - First data on COVID-19 vaccine responses in patients with NAFLD and liver transplant recipients. J Hepatol 2021 DOI: 10.1016/j.jhep.2021.05.007 Kuhlmann E, Dussault G, Correia T. Global health and health workforce development: what to learn from COVID-19 on health workforce preparedness and resilience. Int J Health Plann Manage 2021;36(S1):5-8 DOI: 10.1002/hpm.3160 Plouffe B, Van Hooren T, Barton M, Nashid N, Demirkaya E, Norozi K, Rachinsky I, Delport J, Knauer M, Tole S, Filler G. Renal Infarcts-A Perplexing Case in the Middle of the COVID-19 Pandemic. Front Pediatr 2021;9:669453 DOI: 10.3389/fped.2021.669453 Aulenkamp J, Mikuteit M, Loffler T, Schmidt J. Overview of digital health teaching courses in medical education in Germany in 2020. GMS J Med Educ 2021;38(4):Doc80 DOI: 10.3205/zma001476 Kielstein JT, Borchina DN, Fuhner T, Hwang S, Mattoon D, Ball AJ. Hemofiltration with the Seraph((R)) 100 Microbind((R)) Affinity filter decreases SARS-CoV-2 nucleocapsid protein in critically ill COVID-19 patients. Crit Care 2021;25(1):190 DOI: 10.1186/s13054-021-03597-3 Eberhardt CS, Balletto E, Cornberg M, Mikulska M. Coronavirus disease 2019 vaccination in transplant recipients. Curr Opin Infect Dis 2021 DOI: 10.1097/QCO.0000000000000739 O'Toole A, Hill V, Pybus OG, Watts A, Bogoch II, Khan K, Messina JP, COVID-19 Genomics UK (COG-UK) consortium, Network for Genomic Surveillance in South Africa (NGS-SA), Brazil-UK CADDE Genomic Network, Tegally H, Lessells RR, Giandhari J, Pillay S, Tumedi KA, Nyepetsi G, Kebabonye M, Matsheka M, Mine M, Tokajian S, Hassan H, Salloum T, Merhi G, Koweyes J, Geoghegan JL, de Ligt J, Ren X, Storey M, Freed NE, Pattabiraman C, Prasad P, Desai AS, Vasanthapuram R, Schulz TF, Steinbruck L, Stadler T, Swiss Viollier Sequencing Consortium, Parisi A, Bianco A, Garcia de Viedma D, Buenestado-Serrano S, Borges V, Isidro J, Duarte S, Gomes JP, Zuckerman NS, Mandelboim M, Mor O, Seemann T, Arnott A, Draper J, Gall M, Rawlinson W, Deveson I, Schlebusch S, McMahon J, Leong L, Lim CK, Chironna M, Loconsole D, Bal A, Josset L, Holmes E, St George K, Lasek-Nesselquist E, Sikkema RS, Oude Munnink B, Koopmans M, Brytting M, Sudha Rani V, Pavani S, Smura T, Heim A, Kurkela S, Umair M, Salman M, Bartolini B, Rueca M, Drosten C, Wolff T, Silander O, Eggink D, Reusken C, Vennema H, Park A, Carrington C, Sahadeo N, Carr M, Gonzalez G, SEARCH Alliance San Diego, National Virus Reference Laboratory, SeqCOVID-Spain, Danish Covid-19 Genome Consortium (DCGC), Communicable Diseases Genomic Network (CDGN), Dutch National SARS-CoV-2 surveillance program, Division of Emerging Infectious Diseases (KDCA), de Oliveira T, Faria N, Rambaut A, Kraemer MUG. Tracking the international spread of SARS-CoV-2 lineages B.1.1.7 and B.1.351/501Y-V2. Wellcome Open Res 2021;6:121 DOI: 10.12688/wellcomeopenres.16661.1 Netea MG, Li Y. Immune memory in individuals with COVID-19. Nat Cell Biol 2021;23(6):582-584 DOI: 10.1038/s41556-021-00689-8 Stankov MV, Cossmann A, Bonifacius A, Dopfer-Jablonka A, Ramos GM, Gödecke N, Scharff AZ, Happle C, Boeck A, Tran AT, Pink I, Hoeper MM, Blasczyk R, Winkler MS, Nehlmeier I, Kempf A, Hofmann-Winkler H, Hoffmann M, Eiz-Vesper B, Pöhlmann S, Behrens GMN. Humoral and cellular immune responses against SARS-CoV-2 variants and human coronaviruses after single BNT162b2 vaccination. Clin Infect Dis 2021 DOI: 10.1093/cid/ciab555 Welte T. Impfstoffe gegen das SARS-Coronavirus-2. Pneumo News 2021;13(3):29-33 DOI: 10.1007/s15033-021-2716-x Tscherne A, Schwarz JH, Rohde C, Kupke A, Kalodimou G, Limpinsel L, Okba NMA, Bosnjak B, Sandrock I, Odak I, Halwe S, Sauerhering L, Brosinski K, Liangliang N, Duell E, Jany S, Freudenstein A, Schmidt J, Werner A, Gellhorn Serra M, Kluver M, Guggemos W, Seilmaier M, Wendtner CM, Forster R, Haagmans BL, Becker S, Sutter G, Volz A. Immunogenicity and efficacy of the COVID-19 candidate vector vaccine MVA-SARS-2-S in preclinical vaccination. Proc Natl Acad Sci U S A 2021;118(28):e2026207118 [pii] DOI: 10.1073/pnas.2026207118 Sachs UJ, Cooper N, Czwalinna A, Müller J, Pötzsch B, Tiede A, Althaus K. PF4-dependent immunoassays in patients with vaccine-induced immune thrombotic thrombocytopenia (VITT): results of an inter-laboratory comparison. Thromb Haemost 2021 DOI: 10.1055/a-1535-9002 Mallet V, Keta-Cov research group. Intravenous ketamine is a risk factor for jaundice in Covid-19 patients. J Hepatol 2021 DOI: 10.1016/j.jhep.2021.06.024 Körper S, Jahrsdörfer B, Corman VM, Pilch J, Wuchter P, Blasczyk R, Müller R, Tonn T, Bakchoul T, Schäfer R, Juhl D, Schwarz T, Gödecke N, Burkhardt T, Schmidt M, Appl T, Eichler H, Klüter H, Drosten C, Seifried E, Schrezenmeier H. Donors for SARS-CoV-2 Convalescent Plasma for a Controlled Clinical Trial: Donor Characteristics, Content and Time Course of SARS-CoV-2 Neutralizing Antibodies. Transfus Med Hemother 2021;48(3):137-147 DOI: 10.1159/000515610 Smadja DM, Mentzer SJ, Fontenay M, Laffan MA, Ackermann M, Helms J, Jonigk D, Chocron R, Pier GB, Gendron N, Pons S, Diehl JL, Margadant C, Guerin C, Huijbers EJM, Philippe A, Chapuis N, Nowak-Sliwinska P, Karagiannidis C, Sanchez O, Kumpers P, Skurnik D, Randi AM, Griffioen AW. COVID-19 is a systemic vascular hemopathy: insight for mechanistic and clinical aspects. Angiogenesis 2021 DOI: 10.1007/s10456-021-09805-6 Dinkel A, Goerling U, Honig K, Karger A, Maatouk I, Petermann-Meyer A, Senf B, Woellert K, Wunsch A, Zimmermann T, Schulz-Kindermann F. Psychooncological care for patients with cancer during twelve months of the Covid-19 pandemic: Views and experiences of senior psychooncologists at German Comprehensive Cancer Centers. Psychooncology 2021 DOI: 10.1002/pon.5759 Fernandez Villalobos NV, Ott JJ, Klett-Tammen CJ, Bockey A, Vanella P, Krause G, Lange B. Effect modification of the association between comorbidities and severe course of COVID-19 disease by age of study participants: a systematic review and meta-analysis. Syst Rev 2021;10(1):194 DOI: 10.1186/s13643-021-01732-3 Zeidler H, Hudson AP. Reactive Arthritis Update: Spotlight on New and Rare Infectious Agents Implicated as Pathogens. Curr Rheumatol Rep 2021;23(7):53 DOI: 10.1007/s11926-021-01018-6 Publications with the PMID: 34228347 - 35013790 Malin JJ, Spinner CD, Janssens U, Welte T, Weber-Carstens S, Schalte G, Gastmeier P, Langer F, Wepler M, Westhoff M, Pfeifer M, Rabe KF, Hoffmann F, Bottiger BW, Weinmann-Menke J, Kersten A, Berlit P, Krawczyk M, Nehls W, Fichtner F, Laudi S, Stegemann M, Skoetz N, Nothacker M, Marx G, Karagiannidis C, Kluge S. Key summary of German national treatment guidance for hospitalized COVID-19 patients - Key pharmacologic recommendations from a national German living guideline using an Evidence to Decision Framework. Infection 2021 DOI: 10.1007/s15010-021-01645-2 Ackermann M, Jonigk DD. Microvascular placental alterations in a maternal COVID-19 infection. Am J Obstet Gynecol 2021 DOI: 10.1016/j.ajog.2021.06.098 Zeidler H. Post-COVID19-Arthritis. Manifestation unter dem klinischen Bild einer reaktiven Arthritis. Z Rheumatol 2021 DOI: 10.1007/s00393-021-01045-9 Park DH, Fuge J, Meltendorf T, Kahl KG, Richter MJ, Gall H, Ghofrani HA, Kamp JC, Hoeper MM, Olsson KM. Impact of SARS-CoV-2-Pandemic on Mental Disorders and Quality of Life in Patients With Pulmonary Arterial Hypertension. Front Psychiatry 2021 DOI: 10.3389/fpsyt.2021.668647 Daentzer D. Die Videosprechstunde: Anwendungsverhalten bei Orthopäden und Unfallchirurgen während der COVID-19-Pandemie. Zukünftiger Dauerbrenner oder nur Eintagsfliege? Z Orthop Unfall 2021 DOI: 10.1055/a-1471-8919 Soleimani M, Haverich A, Wriggers P. Mathematical Modeling and Numerical Simulation of Atherosclerosis Based on a Novel Surgeon's View. Arch Comput Methods Eng 2021:1-20 DOI: 10.1007/s11831-021-09623-5 Kaufeld JK, Reinhardt M, Schroder C, Brasen JH, Wiech T, Brylka P, Khaled A, Bergmann C, Haller H, Gackler A, Schmidt BMW. Atypical HUS triggered by infection with SARS-CoV2. Kidney Int Rep 2021 DOI: 10.1016/j.ekir.2021.07.004 Barros-Martins J, Hammerschmidt SI, Cossmann A, Odak I, Stankov MV, Morillas Ramos G, Dopfer-Jablonka A, Heidemann A, Ritter C, Friedrichsen M, Schultze-Florey C, Ravens I, Willenzon S, Bubke A, Ristenpart J, Janssen A, Ssebyatika G, Bernhardt G, Münch J, Hoffmann M, Pöhlmann S, Krey T, Bosnjak B, Förster R, Behrens GMN. Immune responses against SARS-CoV-2 variants after heterologous and homologous ChAdOx1 nCoV-19/BNT162b2 vaccination. Nat Med 2021 DOI: 10.1038/s41591-021-01449-9 Dähne T, Bauer W, Essig A, Schaaf B, Spinner CD, Pletz MW, Rohde G, Rupp J, Witzenrath M, Panning, Members of the CAPNETZ study group. The impact of the SARS-CoV-2 pandemic on the prevalence of respiratory tract pathogens in patients with community-acquired pneumonia in Germany. Emerg Microbes Infect 2021:1-8 DOI: 10.1080/22221751.2021.1957402 Hoffmann M, Hofmann-Winkler H, Krüger N, Kempf A, Nehlmeier I, Graichen L, Arora P, Sidarovich A, Moldenhauer AS, Winkler MS, Schulz S, Jack HM, Stankov MV, Behrens GMN, Pöhlmann S. SARS-CoV-2 variant B.1.617 is resistant to bamlanivimab and evades antibodies induced by infection and vaccination. Cell Rep 2021 DOI: 10.1016/j.celrep.2021.109415 Bertoglio F, Fühner V, Ruschig M, Heine PA, Abassi L, Klünemann T, Rand U, Meier D, Langreder N, Steinke S, Ballmann R, Schneider KT, Roth KDR, Kuhn P, Riese P, Schäckermann D, Korn J, Koch A, Chaudhry MZ, Eschke K, Kim Y, Zock-Emmenthal S, Becker M, Scholz M, Moreira GMSG, Wenzel EV, Russo G, Garritsen HSP, Casu S, Gerstner A, Roth G, Adler J, Trimpert J, Hermann A, Schirrmann T, Dübel S, Frenzel A, Van den Heuvel J, Cicin-Sain L, Schubert M, Hust M. A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients binds to the ACE2-RBD interface and is tolerant to most known RBD mutations. Cell Rep 2021 DOI: 10.1016/j.celrep.2021.109433 Kirchner T, Jaeckel E, Falk CS, Eiz-Vesper B, Taubert R. SARS-CoV-2-specific immunity in immunosuppressed COVID-19 convalescents with autoimmune hepatitis. J Hepatol 2021 DOI: 10.1016/j.jhep.2021.07.012 Crome M, Adam K, Flohr M, Rahman A, Staufenbiel I. Application of the inverted classroom model in the teaching module "new classification of periodontal and peri-implant diseases and conditions" during the COVID-19 pandemic. GMS J Med Educ 2021;38(5):Doc89 DOI: 10.3205/zma001485 Neves AL, Li E, Serafini A, Gimenez GL, Lingner H, Koskela T, Hoffman RD, Collins C, Petek D, Claveria A, Tsopra R, Irving G, Gusso G, O'Neill BG, Hoedebecke K, Espitia SM, Ungan M, Nessler K, Lazic V, Laranjo L, Ensieh M, Fernandez MJ, Ghafur S, Fontana G, Majeed A, Car J, Darzi A. Evaluating the impact of COVID-19 on the adoption of virtual care in general practice in 20 countries (inSIGHT): rationale and study protocol. JMIR Res Protoc 2021 DOI: 10.2196/30099 Schmidt JJ, Bode-Böger SM, Martens-Lobenhoffer J, Hoeper MM, Kielstein JT. Pharmacokinetics of Remdesivir and GS-441524 during PIRRT and Seraph 100 Therapy. Clin J Am Soc Nephrol 2021 DOI: 10.2215/CJN.17601120 Betz K, van der Velden R, Gawalko M, Hermans A, Pluymaekers N, Hillmann HAK, Hendriks J, Duncker D, Linz D. Interpretation der Photoplethysmographie: Schritt für Schritt. Elektrophysiol 2021 DOI: 10.1007/s00399-021-00795-y Tielker JM, Weber JP, Simon ST, Bausewein C, Stiel S, Schneider N. Experiences, challenges and perspectives for ensuring end-of-life patient care: A national online survey with general practitioners in Germany. PLoS ONE 2021;16(7):e0254056 DOI: 10.1371/journal.pone.0254056 Jendrny P, Twele F, Meller S, Schulz C, von Köckritz-Blickwede M, Osterhaus ADME, Ebbers H, Ebbers J, Pilchova V, Pink I, Welte T, Manns MP, Fathi A, Addo MM, Ernst C, Schäfer W, Engels M, Petrov A, Marquart K, Schotte U, Schalke E, Volk HA. Scent dog identification of SARS-CoV-2 infections in different body fluids. BMC Infect Dis 2021 ;21(1):707 DOI: 10.1186/s12879-021-06411-1 Düppers AL, Bohnhorst B, Bültmann E, Schulz T, Higgins-Wood L, von Kaisenberg CS. Severe fetal brain damage subsequent to acute maternal hypoxemic deterioration in COVID-19. Ultrasound Obstet Gynecol 2021 DOI: 10.1002/uog.23744 Pommerenke C, Rand U, Uphoff CC, Nagel S, Zaborski M, Hauer V, Kaufmann M, Meyer C, Denkmann SA, Riese P, Eschke K, Kim Y, Safranko ZM, Kurolt IC, Markotic A, Cicin-Sain L, Steenpass L. Identification of cell lines CL-14, CL-40 and CAL-51 as suitable models for SARS-CoV-2 infection studies. PLoS One 2021;16(8) DOI: 10.1371/journal.pone.025562 Seifert J, Heck J, Eckermann G, Singer M, Bleich S, Grohmann R, Toto S. COVID-19-Impfung unter Psychopharmakotherapie. Psychiatr Prax 2021 DOI: 10.1055/a-1531-4460 Ricke-Hoch M, Stelling E, Lasswitz L, Gunesch AP, Kasten M, Zapatero-Belinchon FJ, Brogden G, Gerold G, Pietschmann T, Montiel V, Balligand JL, Facciotti F, Hirsch E, Gausepohl T, Elbahesh H, Rimmelzwaan GF, Höfer A, Kühnel MP, Jonigk D, Eigendorf J, Tegtbur U, Mink L, Scherr M, Illig T, Schambach A, Pfeffer TJ, Hilfiker A, Haverich A, Hilfiker-Kleiner D. Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease. PLoS One 2021 ;16(8) DOI: 10.1371/journal.pone.0255335 Koeken VACM. Controlling inflammation in the elderly with BCG vaccination. Sci Adv 2021;7(32) DOI: 10.1126/sciadv.abk1668 Tuschen K, Bräsen JH, Schmitz J, Vischedyk M, Weidemann A. Relapse of Class V Lupus Nephritis after Vaccination with COVID-19 mRNA Vaccine. Kidney Int 2021 DOI: 10.1016/j.kint.2021.07.019 Derda AA, Garg A, Bär C, Thum T. Reply to 'COVID-19 severity, miR-21 targets, and common human genetic variation'. Eur J Heart Fail 2021 DOI: 10.1002/ejhf.2322 Rand U, Kupke SY, Shkarlet H, Hein MD, Hirsch T, Marichal-Gallardo P, Cicin-Sain L, Reichl U, Bruder D. Antiviral Activity of Influenza A Virus Defective Interfering Particles against SARS-CoV-2 Replication In Vitro through Stimulation of Innate Immunity. Cells 2021;10(7):1756 DOI: 10.3390/cells10071756 Tumpara S, Gründing AR, Sivaraman K, Wrenger S, Olejnicka B, Welte T, Wurm MJ, Pino P, Kiseljak D, Wurm FM, Janciauskiene S. Boosted Pro-Inflammatory Activity in Human PBMCs by Lipopolysaccharide and SARS-CoV-2 Spike Protein Is Regulated by alpha-1 Antitrypsin. Int J Mol Sci 2021;22(15):7941 DOI: 10.3390/ijms22157941 Kremsner PG, Mann P, Kroidl A, Leroux-Roels I, Schindler C, Gabor JJ, Schunk M, Leroux-Roels G, Bosch JJ, Fendel R, Kreidenweiss A, Velavan TP, Fotin-Mleczek M, Mueller SO, Quintini G, Schönborn-Kellenberger O, Vahrenhorst D, Verstraeten T, Alves de Mesquita M, Walz L, Wolz OO, Oostvogels L, CV-NCOV-001 Study Group. Safety and immunogenicity of an mRNA-lipid nanoparticle vaccine candidate against SARS-CoV-2 : A phase 1 randomized clinical trial. Wien Klin Wochenschr 2021 DOI: 10.1007/s00508-021-01922-y Strengert M, Becker M, Ramos GM, Dulovic A, Gruber J, Juengling J, Lürken K, Beigel A, Wrenger E, Lonnemann G, Cossmann A, Stankov MV, Dopfer-Jablonka A, Kaiser PD, Traenkle B, Rothbauer U, Krause G, Schneiderhan-Marra N, Behrens GMN. Cellular and humoral immunogenicity of a SARS-CoV-2 mRNA vaccine in patients on haemodialysis. EBioMedicine 2021;70 DOI: 10.1016/j.ebiom.2021.103524 Pfaar O, Klimek L, Hamelmann E, Kleine-Tebbe J, Taube C, Wagenmann M, Werfel T, Brehler R, Novak N, Mülleneisen NK, Becker S, Worm M. COVID-19-Impfungen von Patienten mit Allergien und Typ2-entzündlichen Erkrankungen bei gleichzeitiger Antikorpertherapie (Biologika): Ein Positionspapier der Deutschen Gesellschaft für Allergologie und klinische Immunologie (DGAKI) und dem Ärzteverband Deutscher Allergologen (AeDA). Allergo J 2021;30(5):24-33 DOI: 10.1007/s15007-021-4846-1 Mariani S, Schöde A, Homann K, Feueriegel S, Nöth S, Warnke K, Bounader K, Andreeva A, Li T, Dogan G, Haverich A, Schmitto JD. Telemonitoring and Care Program for Left Ventricular Assist Device Patients during COVID-19 Outbreak: Results from a European Experience. ASAIO J 2021 DOI: 10.1097/MAT.0000000000001526 Simovic S, Providencia R, Barra S, Kircanski B, Guerra JM, Conte G, Duncker D, Marijon E, Anic A, Boveda S. The use of remote monitoring of cardiac implantable devices during the COVID-19 pandemic: an EHRA physician survey. Europace 2021 DOI: 10.1093/europace/euab215 Kleineberg NN, Knauss S, Gülke E, Pinnschmidt HO, Jakob CEM, Lingor P, Hellwig K, Berthele A, Höglinger G, Fink GR, Endres M, Gerloff C, Klein C, Stecher M, Classen AY, Rieg S, Borgmann S, Hanses F, Rüthrich MM, Hower M, Tometten L, Haselberger M, Piepel C, Merle U, Dolff S, Degenhardt C, Jensen BO, Vehreschild MJGT, Erber J, Franke C, Warnke C, LEOSS Study Group. Neurological symptoms and complications in predominantly hospitalized COVID-19 patients - results of the European multinational LEOSS registry . Eur J Neurol 2021 DOI: 10.1111/ene.15072 Malin JJ, Spinner CD, Janssens U, Welte T, Weber-Carstens S, Schälte G, Gastmeier P, Langer F, Wepler M, Westhoff M, Pfeifer M, Rabe KF, Hoffmann F, Bottiger BW, Weinmann-Menke J, Kersten A, Berlit P, Krawczyk M, Nehls W, Fichtner F, Laudi S, Stegemann M, Skoetz N, Nothacker M, Marx G, Karagiannidis C, Kluge S. Correction to: Key summary of German national treatment guidance for hospitalized COVID19 patients : Key pharmacologic recommendations from a national German living guideline using an Evidence to Decision Framework (last updated 17.05.2021). Infection 2021 DOI: 10.1007/s15010-021-01665-y Behrens GM, Cossmann A, Stankov MV, Nehlmeier I, Kempf A, Hoffmann M, Pöhlmann S. SARS-CoV-2 delta variant neutralisation after heterologous ChAdOx1-S/BNT162b2 vaccination. Lancet 2021 DOI: 10.1016/S0140-6736(21)01891-2 Hammerschmidt SI, Bosnjak B, Bernhardt G, Friedrichsen M, Ravens I, Dopfer-Jablonka A, Hoffmann M, Pöhlmann S, Behrens GMN, Förster R. Neutralization of the SARS-CoV-2 Delta variant after heterologous and homologous BNT162b2 or ChAdOx1 nCoV-19 vaccination. Cell Mol Immunol 2021 DOI: 10.1038/s41423-021-00755-z Kahnert K, Lutter JI, Welte T, Alter P, Behr J, Herth F, Kauczor HU, Söhler S, Pfeifer M, Watz H, Vogelmeier CF, Bals R, Jorres RA, Trudzinski FC. Impact of the COVID-19 pandemic on the behaviour and health status of patients with COPD: results from the German COPD cohort COSYCONET. ERJ Open Res 2021;7(3):00242-2021 DOI: 10.1183/23120541.00242 Kilic G, Bulut O, Jaeger M, Ter Horst R, Koeken VACM, Moorlag SJCFM, Mourits VP, de Bree C, Dominguez-Andres J, Joosten LAB, Netea MG. The Immunological Factors Predisposing to Severe Covid-19 Are Already Present in Healthy Elderly and Men. Front Immunol 2021 ;12:720090 DOI: 10.3389/fimmu.2021.720090 Wong DWL, Klinkhammer BM, Djudjaj S, Villwock S, Timm MC, Buhl EM, Wucherpfennig S, Cacchi C, Braunschweig T, Knüchel-Clarke R, Jonigk D, Werlein C, Bülow RD, Dahl E, von Stillfried S, Boor P. Multisystemic Cellular Tropism of SARS-CoV-2 in Autopsies of COVID-19 Patients. Cells 2021 ;10(8):1900 DOI: 10.3390/cells10081900 Bosnjak B, Odak I, Ritter C, Stahl K, Graalmann T, Steinbrück L, Blasczyk R, Falk CS, Schulz TF, Wedemeyer HH, Cornberg M, Ganser A, Förster R, Koenecke C. Case Report: Convalescent Plasma Therapy Induced Anti-SARS-CoV-2 T Cell Expansion, NK Cell Maturation and Virus Clearance in a B Cell Deficient Patient After CD19 CAR T Cell Therapy. Front Immunol 2021 ;12:721738 DOI: 10.3389/fimmu.2021.721738 Jung C, Gillmann HJ, Stueber T, Hinken L. Spontaneous massive hemothorax as a complication of necrotizing pneumonia in a patient with severe acute respiratory syndrome coronavirus 2 induced acute respiratory distress syndrome: a case report. J Med Case Rep 2021;15(1):444 DOI: 10.1186/s13256-021-03032-9 Höner Zu Siederdissen C, Schultalbers M, Wübbolding M, Lechte GS, Laser H, Cornberg M, Wedemeyer H, Maasoumy B. Einfluss der COVID-19 Pandemie auf die Notfallversorung von Patienten mit Leberzirrhose - Erfahrungen eines tertiären Zentrums. Z Gastroenterol 2021;59(9):954-960 DOI: 10.1055/a-1540-7726 Bär C, Derda AA, Thum T. MicroRNAs bei COVID-19: kleine Moleküle mit grossem Potenzial? Biospektrum (Heidelb) 2021;27(5):485-487 DOI: 10.1007/s12268-021-1620-6 Maison N, Herbrüggen H, Schaub B, Schauberger C, Foth S, Grychtol R, Abdo M, Watz H, Nikolaizik W, Rabe KF, Kopp MV, Hansen G, von Mutius E, Bahmer T, Omony J, ALLIANCE study group. Impact of imposed social isolation and use of face masks on asthma course and mental health in pediatric and adult patients with recurrent wheeze and asthma. Allergy Asthma Clin Immunol 2021;17(1):93 DOI: 10.1186/s13223-021-00592-9 Klimek L, Pfaar O, Hamelmann E, Kleine-Tebbe J, Taube C, Wagenmann M, Werfel T, Brehler R, Novak N, Mülleneisen N, Becker S, Worm M. COVID-19 vaccination and allergen immunotherapy (AIT) - A position paper of the German Society for Applied Allergology (AeDA) and the German Society for Allergology and Clinical Immunology (DGAKI). Allergol Select 2021;5:251-259 DOI: 10.5414/ALX02245E Kuhlmann E, Bruns L, Hoeper K, Richter M, Witte T, Ernst D, Jablonka A. Arbeitssituation von Rheumatolog*innen und Weiterbildungsassistent*innen in Zeiten von COVID-19 : Ergebnisse einer Erhebung in Deutschland. Z Rheumatol 2021 DOI: 10.1007/s00393-021-01081-5 Stoehr F, Müller L, Brady A, Trilla A, Mähringer-Kunz A, Hahn F, Duber C, Becker N, Worns MA, Chapiro J, Hinrichs JB, Akata D, Ellmann S, Huisman M, Koff D, Brinkmann S, Bamberg F, Zimmermann O, Traikova NI, Marquardt JU, Chang DH, Rengier F, Auer TA, Emrich T, Muehler F, Schmidberger H, Baessler B, Dos Santos DP, Kloeckner R. How COVID-19 kick-started online learning in medical education-The DigiMed study. PLoS One 2021;16(9):e0257394 DOI: 10.1371/journal.pone.0257394 Begemann M, Gross O, Wincewicz D, Hardeland R, Daguano Gastaldi V, Vieta E, Weissenborn K, Miskowiak KW, Moerer O, Ehrenreich H. Addressing the 'hypoxia paradox' in severe COVID-19: literature review and report of four cases treated with erythropoietin analogues. Mol Med 2021;27(1):120 DOI: 10.1186/s10020-021-00381-5 Azimzadeh M, Möhn N, Ghane Ezabadi S, Moghimi Esfandabadi Z, Soleimani A, Ranjbar E, Jahromi M, Seyedebrahimi R, Skripuletz T, Moharrami Kasmaie F. The Immunological Therapeutic Strategies for Controlling Multiple Sclerosis: Considerations during the COVID-19 Pandemic. Biomolecules 2021;11(9):1372 DOI: 10.3390/biom11091372 Sanchez van Kammen M, Aguiar de Sousa D, Poli S, Cordonnier C, Heldner MR, van de Munckhof A, Krzywicka K, van Haaps T, Ciccone A, Middeldorp S, Levi MM, Kremer Hovinga JA, Silvis S, Hiltunen S, Mansour M, Arauz A, Barboza MA, Field TS, Tsivgoulis G, Nagel S, Lindgren E, Tatlisumak T, Jood K, Putaala J, Ferro JM, Arnold M, Coutinho JM, Cerebral Venous Sinus Thrombosis With Thrombocytopenia Syndrome Study Group, Sharma AR, Elkady A, Negro A, Günther A, Gutschalk A, Schönenberger S, Buture A, Murphy S, Paiva Nunes A, Tiede A, Puthuppallil Philip A, Mengel A, Medina A, Hellstrom Vogel A, Tawa A, Aujayeb A, Casolla B, Buck B, Zanferrari C, Garcia-Esperon C, Vayne C, Legault C, Pfrepper C, Tracol C, Soriano C, Guisado-Alonso D, Bougon D, Zimatore DS, Michalski D, Blacquiere D, Johansson E, Cuadrado-Godia E, De Maistre E, Carrera E, Vuillier F, Bonneville F, Giammello F, Bode FJ, Zimmerman J, d'Onofrio F, Grillo F, Cotton F, Caparros F, Puy L, Maier F, Gulli G, Frisullo G, Polkinghorne G, Franchineau G, Cangur H, Katzberg H, Sibon I, Baharoglu I, Brar J, Payen JF, Burrow J, Fernandes J, Schouten J, Althaus K, Garambois K, Derex L, Humbertjean L, Lebrato Hernandez L, Kellermair L, Morin Martin M, Petruzzellis M, Cotelli M, Dubois MC, Carvalho M, Wittstock M, Miranda M, Skjelland M, Bandettini di Poggio M, Scholz MJ, Raposo N, Kahnis R, Kruyt N, Huet O, Sharma P, Candelaresi P, Reiner P, Vieira R, Acampora R, Kern R, Leker R, Coutts S, Bal S, Sharma SS, Susen S, Cox T, Geeraerts T, Gattringer T, Bartsch T, Kleinig TJ, Dizonno V, Arslan Y. Characteristics and Outcomes of Patients With Cerebral Venous Sinus Thrombosis in SARS-CoV-2 Vaccine-Induced Immune Thrombotic Thrombocytopenia. JAMA Neurol 2021 DOI: 10.1001/jamaneurol.2021.3619 Doerdelmann J, Frielitz FS, Lange K, Meinsen T, Reimers S, Ottersberg T, Katalinic A, Hiort O, von Sengbusch S. Video Consultation for Parents with a Child Newly Diagnosed with Type 1 Diabetes: A Qualitative Study Exp Clin Endocrinol Diabetes 2021 DOI: 10.1055/a-1655-5471 Bojkova D, Costa R, Reus P, Bechtel M, Jaboreck MC, Olmer R, Martin U, Ciesek S, Michaelis M, Cinatl J,Jr. Targeting the Pentose Phosphate Pathway for SARS-CoV-2 Therapy Metabolites 2021;11(10):699 DOI: 10.3390/metabo11100699 Kahn M, Zellmer S, Ebigbo A, Muzalyova A, Classen J, Grunherz V, Boser J, Breitling LP, Beyer A, Rosendahl J, Lammert F, Traidl-Hoffmann C, Messmann H, Rommele C. Ein Jahr Covid-19: Testung, Verwendung von Schutzausrüstung und Auswirkungen auf die Gastrointestinale Endoskopie in Deutschland Z Gastroenterol 2021 DOI: 10.1055/a-1649-8184 Debisarun PA, Gossling KL, Bulut O, Kilic G, Zoodsma M, Liu Z, Oldenburg M, Ruchel N, Zhang B, Xu CJ, Struycken P, Koeken VACM, Dominguez-Andres J, Moorlag,S J C F M., Taks E, Ostermann PN, Muller L, Schaal H, Adams O, Borkhardt A, Ten Oever J, van Crevel R, Li Y, Netea MG. Induction of trained immunity by influenza vaccination - impact on COVID-19 PLoS Pathog 2021;17(10):e1009928-e1009928 DOI: 10.1371/journal.ppat.1009928 Concha G, Frickmann H, Oey A, Strengert M, Kreienbrock L, Kann S. Direct and Indirect Proof of SARS-CoV-2 Infections in Indigenous Wiwa Communities in North-Eastern Colombia-A Cross-Sectional Assessment Providing Preliminary Surveillance Data Vaccines (Basel) 2021;9(10):1120 DOI: 10.3390/vaccines9101120 Eisfeld HS, Simonis A, Winter S, Chhen J, Stroh LJ, Krey T, Koch M, Theobald SJ, Rybniker J. Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages Viruses 2021;13(10):2076 DOI: 10.3390/v13102076 Arora P, Rocha C, Kempf A, Nehlmeier I, Graichen L, Winkler MS, Lier M, Schulz S, Jack HM, Cossmann A, Stankov MV, Behrens GMN, Pohlmann S, Hoffmann M. The spike protein of SARS-CoV-2 variant A.30 is heavily mutated and evades vaccine-induced antibodies with high efficiency Cell Mol Immunol 2021 DOI: 10.1038/s41423-021-00779-5 Aliee H, Massip F, Qi C, de Biase MS, van Nijnatten J, Kersten ETG, Kermani NZ, Khuder B, Vonk JM, Vermeulen RCH, U-BIOPRED study group, Cambridge Lung Cancer Early Detection Programme,INER-Ciencias Mexican Lung Program, Neighbors M, Tew GW, Grimbaldeston MA, Ten Hacken NHT, Hu S, Guo Y, Zhang X, Sun K, Hiemstra PS, Ponder BA, Makela MJ, Malmstrom K, Rintoul RC, Reyfman PA, Theis FJ, Brandsma CA, Adcock IM, Timens W, Xu CJ, van den Berge M, Schwarz RF, Koppelman GH, Nawijn MC, Faiz A. Determinants of expression of SARS-CoV-2 entry related genes in upper and lower airways Allergy 2021 DOI: 10.1111/all.15152 Jedicke N, Stankov MV, Cossmann A, Dopfer-Jablonka A, Knuth C, Ahrenstorf G, Ramos GM, Behrens GMN. Humoral immune response following prime and boost BNT162b2 vaccination in people living with HIV on antiretroviral therapy. HIV Med 2021 DOI: 10.1111/hiv.13202 Ackermann M, Tafforeau P, Wagner WL, Walsh C, Werlein C, Kühnel MP, Langer FP, Disney C, Bodey AJ, Bellier A, Verleden SE, Lee PD, Mentzer SJ, Jonigk DD. The Bronchial Circulation in COVID-19 Pneumonia. Am J Respir Crit Care Med 2021 DOI: 10.1164/rccm.202103-0594IM Walsh CL, Tafforeau P, Wagner WL, Jafree DJ, Bellier A, Werlein C, Kühnel MP, Boller E, Walker-Samuel S, Robertus JL, Long DA, Jacob J, Marussi S, Brown E, Holroyd N, Jonigk DD, Ackermann M, Lee PD. Imaging intact human organs with local resolution of cellular structures using hierarchical phase-contrast tomography. Nat Methods 2021 DOI: 10.1038/s41592-021-01317-x Teich N, Ludewig C, Schmelz R, Bastlein EC, Geissler S, Nagl S, Walldorf J, Krause T, Maaser C, Mohl W, Wedemeyer HH, Bauer T, Buning C, Grunert P, Hasselblatt P, Hanschen M, Kahl M, Engelke O, Schubert S, Holler B, Streetz K, Arnim UV, Schmidt K, Stallmach A, fur die German IBD Study Group, Collaborators:, Jochen Maul B, Axel Schweitzer M, Wolfgang Breit D, Jan-Hinnerk Hofer K, Marc Eisold M, Michael R. Mross B, Stefanie Howaldt H, Stefanie Strobl I, Robert Ehehalt H, Klaus Schmidt L, Carsten Triller H, Serhat Aymaz D, Thorsten Brechmann B, Axel Dignass F, Elisabeth Schnoy A, Bernd Swarovsky A, Dr. med. Birgit Gerhard, Berlin, Doris Zink N, Ulrich Finger B, Franz Josef Heil A, Gerd-Rudiger Franke D, Gunther Bohm L, Jens Hunkemoller O, Martin Schmidt-Lauber O, Mirko Vonderach O, Olaf Mensler O, Rainer Kunz F, Richard Kolble D, Christoph Rother S, Ulf Klonne G, Ulrich Graefe B, Wolfgang Schwarz H, Georg Schmitz D, Hans Vibrans C, Thomas Witthoft S, Tobias Klugmann L, Martin Reuther L, Frank Bulow K, Carsten Ising W, Christoph Balzer S, Julia Morgenstern K, Markus Casper S, Ron Winograd A, Tilman Pickartz G, Marco Wagner W, Christoph Schmidt B, Wolfgang Vogt E, Sabine Blau F, Rolf Seipel K, Gisela Felten H, Philipp A. Reuken J, Jorg Kapp U, Maximilian Gemeinhardt G, Jorg Christian Metzler, Schwabisch Gmund, Martin Hoffstadt I, Susanne Wuchner-Hofmann D. Auswirkungen einer SARS-CoV-2-Infektion auf Symptomatik und Therapie chronisch-entzündlicher Darmerkrankungen. Z Gastroenterol 2021;59(11):1189-1196 DOI: 10.1055/a-1508-6734 Kuhlmann E, Brinzac MG, Burau V, Correia T, Ungureanu MI. Health workforce protection and preparedness during the COVID-19 pandemic: a tool for the rapid assessment of EU health systems. Eur J Public Health 2021;31(Supplement_4):iv14-iv20 DOI: 10.1093/eurpub/ckab152 Patecki M, Merscher S, Dumann H, Bernhardt W, Dopfer-Jablonka A, Cossmann A, Stankov MV, Einecke G, Haller H, Schlieper G, Behrens GM. Similar humoral immune responses in peritoneal dialysis and haemodialysis patients after two doses of the SARS-CoV-2 vaccine BNT162b2. Perit Dial Int 2021 DOI: 10.1177/08968608211055631 Herth FJF, Sandhaus RA, Turner AM, Sucena M, Welte T, Greulich T. Alpha 1 Antitrypsin Therapy in Patients with Alpha 1 Antitrypsin Deficiency: Perspectives from a Registry Study and Practical Considerations for Self-Administration During the COVID-19 Pandemic. Int J Chron Obstruct Pulmon Dis 2021;16:2983-2996 DOI: 10.2147/COPD.S325211 Suhren J, Meinardus A, Hussein K, Schaumann N. Meta-analysis on COVID-19-pregnancy-related placental pathologies shows no specific pattern. Placenta 2021 ;117:72-77 DOI: 10.1016/j.placenta.2021.10.010 Zapatero-Belinchon FJ, Moeller R, Lasswitz L, van Ham M, Becker M, Brogden G, Rosendal E, Bi W, Carriqui-Madronal B, Islam K, Lenman A, Gunesch AP, Kirui J, Pietschmann T, Overby AK, Jansch L, Gerold G. Fluvastatin mitigates SARS-CoV-2 infection in human lung cells. iScience 2021:103469 DOI: 10.1016/j.isci.2021.103469 Sitter M, Schlesinger T, Reinhold AK, Scholler A, von Heymann C, Welfle S, Bartmann C, Wockel A, Kleinschmidt S, Schneider S, Gottschalk A, Greve S, Wermelt JZ, Wiener R, Schulz F, Chappell D, Brunner M, Neumann C, Meybohm P, Kranke P, Weitere Mitglieder des COALA-Registers. COVID-19 in der geburtshilflichen Anästhesie : Prospektive Erfassung von SARS-CoV-2-Infektionen zum Zeitpunkt der Geburt sowie des peripartalen Verlaufs SARS-CoV-2-positiver Schwangerer. Anaesthesist 2021 DOI: 10.1007/s00101-021-01068-6 Rabe JE, Schillok H, Merkel C, Voss S, Coenen M, De Bock F, von Rüden U, Bramesfeld A, Jung-Sievers C, COSMO-Gruppe. Belastung von Eltern mit Kindern im Schulalter während verschiedener Phasen der COVID-19-Pandemie in Deutschland: Eine Analyse der COVID-19-Snapshot-Monitoring-(COSMO)Daten. Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 2021 DOI: 10.1007/s00103-021-03453-3 Nicolay W, Moeller R, Kahl S, Vondran FWR, Pietschmann T, Kunz S, Gerold G. Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human Hepatocytes. Cells 2021;10(11):3019 DOI: 10.3390/cells10113019 Dong TN, Brogden G, Gerold G, Khosla M. A multitask transfer learning framework for the prediction of virus-human protein-protein interactions. BMC Bioinformatics 2021;22(1):572 DOI: 10.1186/s12859-021-04484-y Fuehner T, Renger I, Welte T, Freundt T, Gottlieb J. Silent Hypoxia in COVID-19: A Case Series. Respiration 2021 DOI: 10.1159/000520083 Enechukwu AOM, Bucher F, Dastagir K, Jokuszies A, Vogt PM, Könneker S. Treatment of hand infections using WALANT -when the anesthesiologist is not available: A retrospective cohort study. Ann Med Surg (Lond) 2021;71:102993 DOI: 10.1016/j.amsu.2021.102993 Anjorin AA, Odetokun IA, Abioye AI, Elnadi H, Umoren MV, Damaris BF, Eyedo J, Umar HI, Nyandwi JB, Abdalla MM, Tijani SO, Awiagah KS, Idowu GA, Fabrice SNA, Maisara AMO, Razouqi Y, Mhgoob ZE, Parker S, Asowata OE, Adesanya IO, Obara MA, Jaumdally S, Kitema GF, Okuneye TA, Mbanzulu KM, Daitoni H, Hallie EF, Mosbah R, Fasina FO. Will Africans take COVID-19 vaccination? PLoS One 2021;16(12):e0260575 DOI: 10.1371/journal.pone.0260575 Miller K, Bergmann L, Doehn C, Grünwald V, Gschwend JE, Ivanyi P, Kuczyk MA. Interdisziplinäre Empfehlungen zur Behandlung des fortgeschrittenen Nierenzellkarzinoms. Aktuelle Urol 2021 DOI: 10.1055/a-1579-0562 Wienecke LM, Cohen S, Bauersachs J, Mebazaa A, Chousterman BG. Immunity and inflammation: the neglected key players in congenital heart disease? Heart Fail Rev 2021 DOI: 10.1007/s10741-021-10187-6 Bosnjak B, Odak I, Barros-Martins J, Sandrock I, Hammerschmidt SI, Permanyer M, Patzer GE, Greorgiev H, Gutierrez Jauregui R, Tscherne A, Schwarz JH, Kalodimou G, Ssebyatika G, Ciurkiewicz M, Willenzon S, Bubke A, Ristenpart J, Ritter C, Tuchel T, Meyer Zu Natrup C, Shin DL, Clever S, Limpinsel L, Baumgärtner W, Krey T, Volz A, Sutter G, Förster R. Intranasal Delivery of MVA Vector Vaccine Induces Effective Pulmonary Immunity Against SARS-CoV-2 in Rodents. Front Immunol 2021;12:772240 DOI: 10.3389/fimmu.2021.772240 Wygrecka M, Birnhuber A, Seeliger B, Michalick L, Pak O, Schultz AS, Schramm F, Zacharias M, Gorkiewicz G, David S, Welte T, Schmidt JJ, Weissmann N, Schermuly RT, Barreto G, Schaefer L, Markart P, Brack MC, Hippenstiel S, Kurth F, Sander LE, Witzenrath M, Kuebler WM, Kwapiszewska G, Preissner KT. Altered fibrin clot structure and dysregulated fibrinolysis contribute to thrombosis risk in severe COVID-19. Blood Adv 2022;6(3):1074-1087 DOI: 10.1182/bloodadvances.2021004816 Ten Hagen NA, Twele F, Meller S, Jendrny P, Schulz C, von Köckritz-Blickwede M, Osterhaus A, Ebbers H, Pink I, Welte T, Manns MP, Illig T, Fathi A, Addo MM, Nitsche A, Puyskens A, Michel J, Krause E, Ehmann R, von Brunn A, Ernst C, Zwirglmaier K, Wölfel R, Nau A, Philipp E, Engels M, Schalke E, Volk HA. Discrimination of SARS-CoV-2 Infections From Other Viral Respiratory Infections by Scent Detection Dogs. Front Med (Lausanne) 2021;8:749588 DOI: 10.3389/fmed.2021.749588 Hammerschmidt SI, Thurm C, Bosnjak B, Bernhardt G, Reinhold A, Willenzon S, Ritter C, Reinhold D, Schraven B, Förster R. Robust induction of neutralizing antibodies against the SARS-CoV-2 Delta variant after homologous Spikevax or heterologous Vaxzevria-Spikevax vaccination. Eur J Immunol 2021; 52(2):356-359 DOI: 10.1002/eji.202149645 Schmidt JJ, Borchina DN, van T Klooster M, Bulhan-Soki K, Okioma R, Herbst L, Rodríguez DS, Premužić V, Büttner S, Bader B, Serednicki W, Zasada E, Schmitz M, Quabach RA, Hrincheva M, Fühner T, Kielstein JT. Interim-analysis of the COSA (COVID-19 patients treated with the Seraph® 100 Microbind® Affinity filter) registry. Nephrol Dial Transplant 2021 DOI: 10.1093/ndt/gfab347 Ruhl L, Pink I, Kühne JF, Beushausen K, Keil J, Christoph S, Sauer A, Boblitz L, Schmidt J, David S, Jäck HM, Roth E, Cornberg M, Schulz TF, Welte T, Höper MM, Falk CS. Endothelial dysfunction contributes to severe COVID-19 in combination with dysregulated lymphocyte responses and cytokine networks. Signal Transduct Target Ther 2021;6(1):418 DOI: 10.1038/s41392-021-00819-6 Gussarow D, Bonifacius A, Cossmann A, Stankov MV, Mausberg P, Tischer-Zimmermann S, Gödecke N, Kalinke U, Behrens GMN, Blasczyk R, Eiz-Vesper B. Long-Lasting Immunity Against SARS-CoV-2: Dream or Reality? Front Med (Lausanne ) 2021;8:770381 DOI: 10.3389/fmed.2021.770381 Welte T. Wi(e)der SARS-CoV-2: Epidemiologie, Booster und Impfstoffkombis. Pneumo News 2021;13(6):30-34 DOI: 10.1007/s15033-021-2785-x Reichardt M, Moller Jensen P, Andersen Dahl V, Bjorholm Dahl A, Ackermann M, Shah H, Länger F, Werlein C, Kuehnel MP, Jonigk D, Salditt T. 3D virtual histopathology of cardiac tissue from Covid-19 patients based on phase-contrast X-ray tomography. Elife 2021;10:10.7554/eLife.71359 DOI: 10.7554/eLife.71359 Zychlinsky Scharff A, Paulsen M, Schaefer P, Tanisik F, Sugianto RI, Stanislawski N, Blume H, Schmidt BMW, Heiden S, Stiesch M, Melk A. Students' age and parental level of education influence COVID-19 vaccination hesitancy. Eur J Pediatr 2021 DOI: 10.1007/s00431-021-04343-1 Silenou BC, Nyirenda JLZ, Zaghloul A, Lange B, Doerrbecker J, Schenkel K, Krause G. Availability and Suitability of Digital Health Tools in Africa for Pandemic Control: Scoping Review and Cluster Analysis. JMIR Public Health Surveill 2021;7(12):e30106 DOI: 10.2196/30106 Krey L, Huber MK, Höglinger GU, Wegner F. Can SARS-CoV-2 Infection Lead to Neurodegeneration and Parkinson's Disease? Brain Sci 2021;11(12):1654 [pii] DOI: 10.3390/brainsci11121654 Solmi M, Estrade A, Thompson T, Agorastos A, Radua J, Cortese S, Dragioti E, Leisch F, Vancampfort D, Thygesen LC, Aschauer H, Schloegelhofer M, Akimova E, Schneeberger A, Huber CG, Hasler G, Conus P, Cuenod KQD, von Kanel R, Arrondo G, Fusar-Poli P, Gorwood P, Llorca PM, Krebs MO, Scanferla E, Kishimoto T, Rabbani G, Skonieczna-Zydecka K, Brambilla P, Favaro A, Takamiya A, Zoccante L, Colizzi M, Bourgin J, Kaminski K, Moghadasin M, Seedat S, Matthews E, Wells J, Vassilopoulou E, Gadelha A, Su KP, Kwon JS, Kim M, Lee TY, Papsuev O, Mankova D, Boscutti A, Gerunda C, Saccon D, Righi E, Monaco F, Croatto G, Cereda G, Demurtas J, Brondino N, Veronese N, Enrico P, Politi P, Ciappolino V, Pfennig A, Bechdolf A, Meyer-Lindenberg A, Kahl KG, Domschke K, Bauer M, Koutsouleris N, Winter S, Borgwardt S, Bitter I, Balazs J, Czobor P, Unoka Z, Mavridis D, Tsamakis K, Bozikas VP, Tunvirachaisakul C, Maes M, Rungnirundorn T, Supasitthumrong T, Haque A, Brunoni AR, Costardi CG, Schuch FB, Polanczyk G, Luiz JM, Fonseca L, Aparicio LV, Valvassori SS, Nordentoft M, Vendsborg P, Hoffmann SH, Sehli J, Sartorius N, Heuss S, Guinart D, Hamilton J, Kane J, Rubio J, Sand M, Koyanagi A, Solanes A, Andreu-Bernabeu A, Caceres ASJ, Arango C, Diaz-Caneja CM, Hidalgo-Mazzei D, Vieta E, Gonzalez-Penas J, Fortea L, Parellada M, Fullana MA, Verdolini N, Farkova E, Janku K, Millan M, Honciuc M, Moniuszko-Malinowska A, Loniewski I, Samochowiec J, Kiszkiel L, Marlicz M, Sowa P, Marlicz W, Spies G, Stubbs B, Firth J, Sullivan S, Darcin AE, Aksu H, Dilbaz N, Noyan O, Kitazawa M, Kurokawa S, Tazawa Y, Anselmi A, Cracco C, Machado AI, Estrade N, De Leo D, Curtis J, Berk M, Ward P, Teasdale S, Rosenbaum S, Marx W, Horodnic AV, Oprea L, Alexinschi O, Ifteni P, Turliuc S, Ciuhodaru T, Bolos A, Matei V, Nieman DH, Sommer I, van Os J, van Amelsvoort T, Sun CF, Guu TW, Jiao C, Zhang J, Fan J, Zou L, Yu X, Chi X, de Timary P, van Winke R, Ng B, Pena E, Arellano R, Roman R, Sanchez T, Movina L, Morgado P, Brissos S, Aizberg O, Mosina A, Krinitski D, Mugisha J, Sadeghi-Bahmani D, Sadeghi M, Hadi S, Brand S, Errazuriz A, Crossley N, Ristic DI, Lopez-Jaramillo C, Efthymiou D, Kuttichira P, Kallivayalil RA, Javed A, Afridi MI, James B, Seb-Akahomen OJ, Fiedorowicz J, Carvalho AF, Daskalakis J, Yatham LN, Yang L, Okasha T, Dahdouh A, Gerdle B, Tiihonen J, Shin JI, Lee J, Mhalla A, Gaha L, Brahim T, Altynbekov K, Negay N, Nurmagambetova S, Jamei YA, Weiser M, Correll CU. The collaborative outcomes study on health and functioning during infection times in adults (COH-FIT-Adults): Design and methods of an international online survey targeting physical and mental health effects of the COVID-19 pandemic. J Affect Disord 2022;299:393-407 DOI: 10.1016/j.jad.2021.07.048 Helmert C, Siegels D, Haufe E, Abraham S, Heratizadeh A, Kleinheinz A, Harder I, Schäkel K, Effendy I, Wollenberg A, Sticherling M, Stahl M, Worm M, Schwichtenberg U, Schwarz B, Rossbacher J, Buck PM, Schenck F, Werfel T, Weidinger S, Schmitt J, TREATgermany Study Team. Perception of the coronavirus pandemic by patients with atopic dermatitis - Results from the TREATgermany registry. J Dtsch Dermatol Ges 2022;20(1):45-57 DOI: 10.1111/ddg.14655 Schmidbauer M, Grenacher L, Juchems MS, Memmel E, Lauenstein T, Schreyer AG, Verloh N, Becker C, Vogl TJ, Wessling J, Wacker FK, Ringe KI. Auswirkung der COVID-19-Pandemie auf die radiologische Bildgebung in Deutschland. Rofo 2021 DOI: 10.1055/a-1710-3767 Paulsen M, Zychlinsky Scharff A, de Cassan K, Sugianto RI, Blume C, Blume H, Christmann M, Hauß C, Illig T, Jonczyk R, Klopp N, Kopfnagel V, Lichtinghagen R, Lucas H, Luhr A, Mutschler F, Pietschmann T, Pott P, Prokein J, Schaefer P, Stahl F, Stanislawski N, von der Born J, Schmidt BMW, Heiden S, Stiesch M, Memaran N, Melk A. Children and Adolescents' Behavioral Patterns in Response to Escalating COVID-19 Restriction Reveal Sex and Age Differences. J Adolesc Health 2022;70(3):378-386 DOI: 10.1016/j.jadohealth.2021.11.021 Vanshylla K, Fan C, Wunsch M, Poopalasingam N, Meijers M, Kreer C, Kleipass F, Ruchnewitz D, Ercanoglu MS, Gruell H, Münn F, Pohl K, Janicki H, Nolden T, Bartl S, Stein SC, Augustin M, Dewald F, Gieselmann L, Schommers P, Schulz TF, Sander LE, Koch M, Luksza M, Lässig M, Bjorkman PJ, Klein F. Discovery of ultrapotent broadly neutralizing antibodies from SARS-CoV-2 elite neutralizers. Cell Host Microbe 2022;30(1):69-82.e10 DOI: 10.1016/j.chom.2021.12.010 Bauersachs J, de Boer RA, Lindenfeld J, Bozkurt B. The year in cardiovascular medicine 2021: heart failure and cardiomyopathies. Eur Heart J 2022;43(5):367-376 DOI: 10.1093/eurheartj/ehab887 Bader CD, Panter F, Garcia R, Tchesnokov EP, Haid S, Walt C, Spröer C, Kiefer AF, Götte M, Overmann J, Pietschmann T, Müller R. Sandacrabins - Structurally Unique Antiviral RNA Polymerase Inhibitors from a Rare Myxobacterium. Chemistry 2022;28(10):e202104484 DOI: 10.1002/chem.202104484 Kim Y, Zheng X, Eschke K, Chaudhry MZ, Bertoglio F, Tomic A, Krmpotic A, Hoffmann M, Bar-On Y, Boehme J, Bruder D, Ebensen T, Brunotte L, Ludwig S, Messerle M, Guzman C, Mandelboim O, Hust M, Pöhlmann S, Jonjic S, Cicin-Sain L. MCMV-based vaccine vectors expressing full-length viral proteins provide long-term humoral immune protection upon a single-shot vaccination. Cell Mol Immunol 2022;19(2):234-244 DOI: 10.1038/s41423-021-00814-5 Medenwald D, Brunner T, Christiansen H, Kisser U, Mansoorian S, Vordermark D, Prokosch HU, Seuchter SA, Kapsner LA, our MII research group. Shift of radiotherapy use during the first wave of the COVID-19 pandemic? An analysis of German inpatient data. Strahlenther Onko l 2022 DOI: 10.1007/s00066-021-01883-1 Zellmer S, Bachmann E, Muzalyova A, Ebigbo A, Kahn M, Traidl-Hoffmann C, Frankenberger R, Eckstein FM, Ziebart T, Meisgeier A, Messmann H, Römmele C, Schlittenbauer T. One Year of the COVID-19 Pandemic in Dental Medical Facilities in Germany: A Questionnaire-Based Analysis. Int J Environ Res Public Health 2021;19(1):175 DOI: 10.3390/ijerph19010175 Schreiber A, Viemann D, Schöning J, Schloer S, Mecate Zambrano A, Brunotte L, Faist A, Schöfbänker M, Hrincius E, Hoffmann H, Hoffmann M, Pöhlmann S, Rescher U, Planz O, Ludwig S. The MEK1/2-inhibitor ATR-002 efficiently blocks SARS-CoV-2 propagation and alleviates pro-inflammatory cytokine/chemokine responses. Cell Mol Life Sci 2022;79(1):65 DOI: 10.1007/s00018-021-04085-1 Publications with the PMID: 35020672 - 35786064 Seeliger B, Doebler M, Hofmaenner DA, Wendel-Garcia PD, Schuepbach RA, Schmidt JJ, Welte T, Hoeper MM, Gillmann HJ, Kuehn C, Ehrentraut SF, Schewe JC, Putensen C, Stahl K, Bode C, David S. Intracranial Hemorrhages on Extracorporeal Membrane Oxygenation: Differences Between COVID-19 and Other Viral Acute Respiratory Distress Syndrome. Crit Care Med 2022 DOI: 10.1097/CCM.0000000000005441 Hoffmann M, Krüger N, Schulz S, Cossmann A, Rocha C, Kempf A, Nehlmeier I, Graichen L, Moldenhauer AS, Winkler MS, Lier M, Dopfer-Jablonka A, Jäck HM, Behrens GMN, Pohlmann S. The Omicron variant is highly resistant against antibody-mediated neutralization: Implications for control of the COVID-19 pandemic. Cell 2022;185(3):447-456.e11 DOI: 10.1016/j.cell.2021.12.032 Bausewein C, Hodiamont F, Berges N, Ullrich A, Gerlach C, Oechsle K, Pauli B, Weber J, Stiel S, Schneider N, Krumm N, Rolke R, Gebel C, Jansky M, Nauck F, Wedding U, van Oorschot B, Roch C, Werner L, Fischer M, Schallenburger M, Reuters MC, Schwartz J, Neukirchen M, Gülay A, Maus K, Jaspers B, Radbruch L, Heckel M, Klinger I, Ostgathe C, Kriesen U, Junghanss C, Lehmann E, Gesell D, Gauder S, Boehlke C, Becker G, Pralong A, Strupp J, Leisse C, Schloesser K, Voltz R, Jung N, Simon ST, PallPan Study Group. National strategy for palliative care of severely ill and dying people and their relatives in pandemics (PallPan) in Germany - study protocol of a mixed-methods project. BMC Palliat Care 2022;21(1):10 DOI: 10.1186/s12904-021-00898-w Karagiannidis C, Hentschker C, Westhoff M, Weber-Carstens S, Janssens U, Kluge S, Pfeifer M, Spies C, Welte T, Rossaint R, Mostert C, Windisch W. Observational study of changes in utilization and outcomes in mechanical ventilation in COVID-19. PLoS One 2022;17(1):e0262315 DOI: 10.1371/journal.pone.0262315 Sahajpal NS, Jill Lai CY, Hastie A, Mondal AK, Dehkordi SR, van der Made CI, Fedrigo O, Al-Ajli F, Jalnapurkar S, Byrska-Bishop M, Kanagal-Shamanna R, Levy B, Schieck M, Illig T, Bacanu SA, Chou JS, Randolph AG, Rojiani AM, Zody MC, Brownstein CA, Beggs AH, Bafna V, Jarvis ED, Hoischen A, Chaubey A, Kolhe R, COVID19hostgenomesv consortium. Optical genome mapping identifies rare structural variations as predisposition factors associated with severe COVID-19. iScience 2022:103760 DOI: 10.1016/j.isci.2022.103760 Mang S, Mutlak H, Natanov R, Lotz C, Gill-Schuster D, Bals R, Danziger G, Meybohm P, Combes A, Kühn C, Lepper PM, Muellenbach RM, AWECO-Study Group. Awake ECMO for COVID-19 Induced Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med 2022 DOI: 10.1164/rccm.202105-1189LE Beller J, Schäfers J, Geyer S, Haier J, Epping J. Patterns of Changes in Oncological Care due to COVID-19: Results of a Survey of Oncological Nurses and Physicians from the Region of Hanover, Germany. Healthcare (Basel) 2021;10(1):15 DOI: 10.3390/healthcare10010015 Jarius S, Pache F, Kortvelyessy P, Jelcic I, Stettner M, Franciotta D, Keller E, Neumann B, Ringelstein M, Senel M, Regeniter A, Kalantzis R, Willms JF, Berthele A, Busch M, Capobianco M, Eisele A, Reichen I, Dersch R, Rauer S, Sandner K, Ayzenberg I, Gross CC, Hegen H, Khalil M, Kleiter I, Lenhard T, Haas J, Aktas O, Angstwurm K, Kleinschnitz C, Lewerenz J, Tumani H, Paul F, Stangel M, Ruprecht K, Wildemann B, in cooperation with the German Society for Cerebrospinal Fluid Diagnostics and Clinical Neurochemistry. Cerebrospinal fluid findings in COVID-19: a multicenter study of 150 lumbar punctures in 127 patients . J Neuroinflammation 2022;19(1):19 DOI: 10.1186/s12974-021-02339-0 Wedner-Ross S, Schippert C, von Versen-Höynck F. The impact of the COVID-19 pandemic on women seeking fertility treatment: the patient's perspective. Arch Gynecol Obstet 2022 DOI: 10.1007/s00404-021-06379-y Wang J, Aguirre Mehlhorn M, Ditler K, Effner B, Deserno TM. Tracking Activities of Daily Living in the Home Office. Stud Health Technol Inform 2022;289:162-165 DOI: 10.3233/SHTI210884 Ladas N, Franz S, Haarbrandt B, Sommer KK, Kohler S, Ballout S, Fiebeck J, Marschollek M, Gietzelt M. openEHR-to-FHIR: Converting openEHR Compositions to Fast Healthcare Interoperability Resources (FHIR) for the German Corona Consensus Dataset (GECCO). Stud Health Technol Inform 2022;289:485-486 DOI: 10.3233/SHTI210963 Unterman A, Sumida TS, Nouri N, Yan X, Zhao AY, Gasque V, Schupp JC, Asashima H, Liu Y, Cosme C,Jr, Deng W, Chen M, Raredon MSB, Hoehn KB, Wang G, Wang Z, DeIuliis G, Ravindra NG, Li N, Castaldi C, Wong P, Fournier J, Bermejo S, Sharma L, Casanovas-Massana A, Vogels CBF, Wyllie AL, Grubaugh ND, Melillo A, Meng H, Stein Y, Minasyan M, Mohanty S, Ruff WE, Cohen I, Raddassi K, Yale IMPACT Research Team, Niklason LE, Ko AI, Montgomery RR, Farhadian SF, Iwasaki A, Shaw AC, van Dijk D, Zhao H, Kleinstein SH, Hafler DA, Kaminski N, Dela Cruz CS. Single-cell multi-omics reveals dyssynchrony of the innate and adaptive immune system in progressive COVID-19. Nat Commun 2022;13(1):440 DOI: 10.1038/s41467-021-27716-4 Lasch F, Psarelli EE, Herold R, Mattsson A, Guizzaro L, Petavy F, Schiel A. The impact of Covid-19 on the initiation of clinical trials in Europe and the United States. Clin Pharmacol Ther 2022 DOI: 10.1002/cpt.2534 Barros-Martins J, Förster R, Bosnjak B. NK cell dysfunction in severe COVID-19: TGF-beta-induced downregulation of integrin beta-2 restricts NK cell cytotoxicity. Signal Transduct Target Ther 2022;7(1):32 DOI: 10.1038/s41392-022-00892-5 Barbaud A, Garvey LH, Arcolaci A, Brockow K, Mori F, Mayorga C, Bonadonna P, Atanaskovic-Markovic M, Moral L, Zanoni G, Pagani M, Soria A, Jost M, Caubet JC, Abreu C, Al-Ahmad M, Alvarez-Perea A, Bavbek S, Benedetta B, Beatrice BM, Blanca-Lopez N, Bogas Herrera G, Buonomo A, Calogiuri G, Carli G, Cernadas J, Cortellini G, Celik G, Demir S, Dona I, Dursun Adile B, Eberlein B, Emilia F, Bryan F, Garcez T, Garcia-Nunez I, Gawlik R, Gelincik A, Gomes E, Gooi JH, Grosber M, Gulen T, Hacard F, Cyrille H, Janson C, Johnston SL, Joerg L, Kepil Ozdemir S, Klimek L, Kosnik M, Kowalski ML, Kuyucu S, Kvedariene V, Julio Laguna J, Carla L, Marinho S, Merk H, Meucci E, Morisset M, Munoz-Cano R, Murzilli F, Nakonechna A, Popescu FD, Porebski G, Radice A, Regateiro FS, Rockmann H, Romano A, Sargur R, Sastre J, Kathrin SH, Lenka S, Marta S, Ingrid T, Treudler R, Walusiak-Skorupa J, Wedi B, Wohrl S, Zidarn M, Zuberbier T, Agache I, Torres MJ. Allergies and COVID-19 vaccines: An ENDA/EAACI Position paper. Allergy 2022 DOI: 10.1111/all.15241 Karagiannidis C, Bein T, Welte T. ECMO during the COVID-19 pandemic: moving from rescue therapy to more reasonable indications. Eur Respir J 2022;59(2):2103262 DOI: 10.1183/13993003.03262-2021 Runft S, Färber I, Krüger J, Krüger N, Armando F, Rocha C, Pöhlmann S, Burigk L, Leitzen E, Ciurkiewicz M, Braun A, Schneider D, Baumgärtner L, Freisleben B, Baumgärtner W. Alternatives to animal models and their application in the discovery of species susceptibility to SARS-CoV-2 and other respiratory infectious pathogens: A review. Vet Pathol 2022:3009858211073678 DOI: 10.1177/03009858211073678 Schuhenn J, Meister TL, Todt D, Bracht T, Schork K, Billaud JN, Elsner C, Heinen N, Karakoese Z, Haid S, Kumar S, Brunotte L, Eisenacher M, Di Y, Lew J, Falzarano D, Chen J, Yuan Z, Pietschmann T, Wiegmann B, Uebner H, Taube C, Le-Trilling VTK, Trilling M, Krawczyk A, Ludwig S, Sitek B, Steinmann E, Dittmer U, Lavender KJ, Sutter K, Pfaender S. Differential interferon-alpha subtype induced immune signatures are associated with suppression of SARS-CoV-2 infection. Proc Natl Acad Sci U S A 2022;119(8):e2111600119 DOI: 10.1073/pnas.2111600119 Kalinke U, Barouch DH, Rizzi R, Lagkadinou E, Türeci O, Pather S, Neels P. Clinical development and approval of COVID-19 vaccines. Expert Rev Vaccines 2022 DOI: 10.1080/14760584.2022.2042257 Kamp JC, Neubert L, Ackermann M, Stark H, Werlein C, Fuge J, Haverich A, Tzankov A, Steinestel K, Friemann J, Boor P, Junker K, Hoeper MM, Welte T, Laenger F, Kuehnel MP, Jonigk DD. Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19. Int J Mol Sci 2022;23(3):1583 DOI: 10.3390/ijms23031583 Hebestreit H, Zeidler C, Schippers C, de Zwaan M, Deckert J, Heuschmann P, Krauth C, Bullinger M, Berger A, Berneburg M, Brandstetter L, Deibele A, Dieris-Hirche J, Graessner H, Gündel H, Herpertz S, Heuft G, Lapstich AM, Lücke T, Maisch T, Mundlos C, Petermann-Meyer A, Müller S, Ott S, Pfister L, Quitmann J, Romanos M, Rutsch F, Schaubert K, Schubert K, Schulz JB, Schweiger S, Tüscher O, Ungethum K, Wagner TOF, Haas K, ZSE-DUO working group. Dual guidance structure for evaluation of patients with unclear diagnosis in centers for rare diseases (ZSE-DUO): study protocol for a controlled multi-center cohort study. Orphanet J Rare Dis 2022;17(1):47 DOI: 10.1186/s13023-022-02176-1 Jonczyk R, Stanislawski N, Seiler LK, Blume H, Heiden S, Lucas H, Sarikouch S, Pott PC, Stiesch M, Hauß C, Saletti G, González-Hernández M, Kaiser FK, Rimmelzwaan G, Osterhaus A, Blume C. Combined Prospective Seroconversion and PCR Data of Selected Cohorts Indicate a High Rate of Subclinical SARS-CoV-2 Infections-an Open Observational Study in Lower Saxony, Germany. Microbiol Spectr 2022;10(1):e0151221 DOI: 10.1128/spectrum.01512-21 Hartmann B, Tittel SR, Femerling M, Pfeifer M, Meyhöfer S, Lange K, Milek S, Stemler L, Best F, Holl RW. COVID-19 Lockdown Periods in 2020: Good Maintenance of Metabolic Control in Adults with Type 1 and Type 2 Diabetes. Exp Clin Endocrinol Diabetes 2022 DOI: 10.1055/a-1743-2537 Omer M, Al-Afif S, Machetanz K, Bettag C, Tatagiba M, Rohde V, Krauss JK. Impact of COVID-19 on the Neurosurgical Resident Training Program: an Early Experience. J Neurol Surg A Cent Eur Neurosurg 2022 DOI: 10.1055/s-0042-1743108 Gornyk D, Harries M, Glöckner S, Strengert M, Kerrinnes T, Heise J, Maaß H, Ortmann J, Kessel B, Kemmling Y, Lange B, Krause G. SARS-CoV-2 Seroprevalence in Germany. Dtsch Arztebl Int 2021;118(48):824-831 DOI: 10.3238/arztebl.m2021.0364 Burau V, Falkenbach M, Neri S, Peckham S, Wallenburg I, Kuhlmann E. Health system resilience and health workforce capacities: Comparing health system responses during the COVID-19 pandemic in six European countries. Int J Health Plann Manage 2022 DOI: 10.1002/hpm.3446 Niess AM, Widmann M, Gaidai R, Gölz C, Schubert I, Castillo K, Sachs JP, Bizjak D. COVID-19 in German Competitive Sports: Protocol for a Prospective Multicenter Cohort Study (CoSmo-S). Int J Public Health 2022;67:1604414 DOI: 10.3389/ijph.2022.1604414 Schneider MA, Richtmann S, Gründing AR, Wrenger S, Welte T, Meister M, Kriegsmann M, Winter H, Muley T, Janciauskiene S. Transmembrane serine protease 2 is a prognostic factor for lung adenocarcinoma. Int J Oncol 2022;60(4):39 DOI: 10.3892/ijo.2022.5329 Kerslake R, Randeva HS, Jonigk D, Werlein C, Robertus JL, Katopodis P, Jasker P, Spandidos DA, Kyrou I, Karteris E. Protein expression of transmembrane protease serine 4 in the gastrointestinal tract and in healthy, cancer, and SARS‑CoV‑2 infected lungs. Mol Med Rep 2022;25(4):138 DOI: 10.3892/mmr.2022.12654 Schirmer B, Giehl K, Kubatzky KF. Report of the 24th Meeting on Signal Transduction 2021. Int J Mol Sci 2022;23(4):2015 DOI: 10.3390/ijms23042015 Lommatzsch M, Rabe KF, Taube C, Joest M, Kreuter M, Wirtz H, Blum TG, Kolditz M, Geerdes-Fenge H, Otto-Knapp R, Häcker B, Schaberg T, Ringshausen FC, Vogelmeier CF, Reinmuth N, Reck M, Gottlieb J, Konstantinides S, Meyer J, Worth H, Windisch W, Welte T, Bauer T. Risk Assessment for Patients with Chronic Respiratory Conditions in the Context of the SARS-CoV-2 Pandemic Statement of the German Respiratory Society with the Support of the German Association of Chest Physicians. Respiration 2022;101(3):307-320 DOI: 10.1159/000518896 Schubert M, Bertoglio F, Steinke S, Heine PA, Ynga-Durand MA, Maass H, Sammartino JC, Cassaniti I, Zuo F, Du L, Korn J, Milošević M, Wenzel EV, Krstanović F, Polten S, Pribanić-Matešić M, Brizić I, Baldanti F, Hammarström L, Dübel S, Šustić A, Marcotte H, Strengert M, Protić A, Piralla A, Pan-Hammarström Q, Čičin-Šain L, Hust M. Human serum from SARS-CoV-2-vaccinated and COVID-19 patients shows reduced binding to the RBD of SARS-CoV-2 Omicron variant. BMC Med 2022;20(1):102 DOI: 10.1186/s12916-022-02312-5 Dulovic A, Kessel B, Harries M, Becker M, Ortmann J, Griesbaum J, Jüngling J, Junker D, Hernandez P. Comparative Magnitude and Persistence of Humoral SARS-CoV-2 Vaccination Responses in the Adult Population in Germany. Front Immunol 2022;13:828053 DOI: 10.3389/fimmu.2022.828053 Buske C, Dreyling M, Alvarez-Larrán A, Apperley J, Arcaini L, Besson C, Bullinger L, Corradini P, Giovanni Della Porta M, Dimopoulos M, D'Sa S, Eich HT, Foà R, Ghia P, da Silva MG, Gribben J, Hajek R, Harrison C, Heuser M, Kiesewetter B, Kiladjian JJ, Kröger N, Moreau P, Passweg JR, Peyvandi F, Rea D, Ribera J, Robak T, San-Miguel JF, Santini V, Sanz G, Sonneveld P, von Lilienfeld-Toal M, Wendtner C, Pentheroudakis G, Passamonti F. Managing hematological cancer patients during the COVID-19 pandemic: an ESMO-EHA Interdisciplinary Expert Consensus. ESMO Open 2022;7(2):100403 DOI: 10.1016/j.esmoop.2022.100403 Lotta G, Fernandez M, Kuhlmann E, Wenham C. COVID-19 vaccination challenge: what have we learned from the Brazilian process? Lancet Glob Health 2022 DOI: 10.1016/S2214-109X(22)00049-3 Pabst A, Goetze E, Thiem DGE, Bartella AK, Seifert L, Beiglboeck FM, Kröplin J, Hoffmann J, Zeller A. An update on the current training situation of German interns in oral and maxillofacial surgery at special times in 2021. J Craniomaxillofac Surg 2022 DOI: 10.1016/j.jcms.2022.02.005 Reinecke B, Frericks N, Lauber C, Dinkelborg K, Matthaei A, Vondran FWR, Behrendt P, Haid S, Brown RJP, Pietschmann T. The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection. J Virol 2022 DOI: 10.1128/jvi.01995-21 Sumida TS, Dulberg S, Schupp JC, Lincoln MR, Stillwell HA, Axisa P, Comi M, Unterman A, Kaminski N, Madi A, Kuchroo VK, Hafler DA. Type I interferon transcriptional network regulates expression of coinhibitory receptors in human T cells. Nat Immunol 2022 DOI: 10.1038/s41590-022-01152-y Casper M, Reichert MC, Rissland J, Smola S, Lammert F, Krawczyk M. Pre-endoscopy SARS-CoV-2 testing strategy during COVID-19 pandemic: the care must go on. Eur J Med Res 2022;27(1):41 DOI: 10.1186/s40001-022-00672-5 Friedrich M, Pfeifer G, Binder S, Aigner A, Vollmer Barbosa P, Makert GR, Fertey J, Ulbert S, Bodem J, König E, Geiger N, Schambach A, Schilling E, Buschmann T, Hauschildt S, Koehl U, Sewald K. Selection and Validation of siRNAs Preventing Uptake and Replication of SARS-CoV-2. Front Bioeng Biotechnol 2022;10:801870 DOI: 10.3389/fbioe.2022.801870 Bode L, Dietrich DE, Spannhuth CW, Ludwig H. Prominent Efficacy of Amantadine against Human Borna Disease Virus Infection In Vitro and In Vivo. Comment on Fink et al. Amantadine Inhibits SARS-CoV-2 In Vitro. Viruses 2021, 13, 539. Viruses 2022;14(3):494 DOI: 10.3390/v14030494 Ryom L, De Miguel R, Cotter AG, Podlekareva D, Beguelin C, Waalewijn H, Arribas JR, Mallon PWG, Marzolini C, Kirk O, Bamford A, Rauch A, Molina JM, Kowalska JD, Guaraldi G, Winston A, Boesecke C, Cinque P, Welch S, Collins S, Behrens GMN, EACS Governing Board. Major revision version 11.0 of the European AIDS Clinical Society Guidelines 2021. HIV Med 2022 DOI: 10.1111/hiv.13268 Pfaar O, Hamelmann E, Klimek L, Taube C, Vogelberg C, Wagenmann M, Werfel T, Worm M. Allergen immunotherapy during the COVID-19 pandemic-A survey of the German Society for Allergy and Clinical Immunology. Clin Transl Allergy 2022;12(3):e12134 DOI: 10.1002/clt2.12134 Beller J, Schäfers J, Haier J, Geyer S, Epping J. Trust in Healthcare during COVID-19 in Europe: vulnerable groups trust the least. Z Gesundh Wiss 2022;12(3):e12134 DOI: 10.1007/s10389-022-01705-3 Griese M, Panagiotou P, Manali ED, Stahl M, Schwerk N, Costa V, Douros K, Kallieri M, Urbantat RM, von Bernuth H, Kolilekas L, Morais L, Ramos A, Landwehr K, Knoflach K, Gothe F, Reiter K, Papaevangelou V, Kaditis AG, Kanaka-Gantenbein C, Papiris SA. Autoimmune pulmonary alveolar proteinosis in children. ERJ Open Res 2022;8(1) DOI: 10.1183/23120541.00701-2021 McLean G, Kamil J, Lee B, Moore P, Schulz TF, Muik A, Sahin U, Türeci Ö, Pather S. The Impact of Evolving SARS-CoV-2 Mutations and Variants on COVID-19 Vaccines. mBio 2022:e0297921 DOI: 10.1128/mbio.02979-21 Tergast TL, Blach S, Tacke F, Berg T, Cornberg M, Kautz A, Manns M, Razavi H, Sarrazin C, Serfert Y, van Thiel I, Zeuzem S, Wedemeyer H. Updated epidemiology of hepatitis C virus infections and implications for hepatitis C virus elimination in Germany. J Viral Hepat 2022 DOI: 10.1111/jvh.13680 Odak I, Schultze-Florey CR, Hammerschmidt SI, Ritter C, Willenzon S, Friedrichsen M, Ravens I, Sikora R, Bayir LM, Gutierrez Jauregui R, Bernhardt G, Stankov MV, Cossmann A, Hansen G, Krey T, Cornberg M, Koenecke C, Behrens GMN, Bošnjak B, Förster R. Longitudinal Tracking of Immune Responses in COVID-19 Convalescents Reveals Absence of Neutralization Activity Against Omicron and Staggered Impairment to Other SARS-CoV-2 Variants of Concern . Front Immunol 2022;13:863039 DOI: 10.3389/fimmu.2022.863039 Jonigk D, Werlein C, Acker T, Aepfelbacher M, Amann KU, Baretton G, Barth P, Bohle RM, Büttner A. Organ manifestations of COVID-19: what have we learned so far (not only) from autopsies? Virchows Arch 2022 DOI: 10.1007/s00428-022-03319-2 Akkermann S, Halling T, Löffler F, Silber-Peest AS, Krüger T, Bleich S, Bauersachs J, Kahl KG, Westhoff-Bleck M. Impact of COVID-19 on Medical Supply in Adults With Congenital Heart Disease. Front Psychiatry 2022;13:812611 DOI: 10.3389/fpsyt.2022.812611 Ruskowski K, Neb H, Talbot SR, Choorapoikayil S, Adam EH, von Knethen A, Zacharowski K, Heinicke U. Persistently Elevated Plasma Levels of RIPK3, MLKL, HMGB1, and RIPK1 in COVID-19 ICU Patients. Am J Respir Cell Mol Biol 2022 DOI: 10.1165/rcmb.2022-0039LE Bludau A, Heinemann S, Mardiko AA, Kaba HEJ, Leha A, von Maltzahn N, Mutters NT, Leistner R, Mattner F, Scheithauer S. Infection control strategies for patients and accompanying persons during the COVID-19 pandemic in German hospitals - Results from a cross-sectional study in March-April 2021. J Hosp Infect 2022 DOI: 10.1016/j.jhin.2022.03.014 Arora P, Zhang L, Rocha C, Sidarovich A, Kempf A, Schulz S, Cossmann A, Manger B, Baier E, Tampe B, Moerer O, Dickel S, Dopfer-Jablonka A, Jäck H, Behrens GMN, Winkler MS, Pöhlmann S, Hoffmann M. Comparable neutralisation evasion of SARS-CoV-2 omicron subvariants BA.1, BA.2, and BA.3. Lancet Infect Dis 2022 DOI: 10.1016/S1473-3099(22)00224-9 Zychlinsky Scharff A, Paulsen M, Schaefer P, Tanisik F, Sugianto RI, Stanislawski N, Blume H, Schmidt BMW, Heiden S, Stiesch M, Melk A. Response to "Letter in response to 'Students' age and parental level of education influence COVID-19 vaccination hesitancy'". Eur J Pediatr 2022 DOI: 10.1007/s00431-022-04432-9 Brendlin AS, Molwitz I, Oechtering TH, Barkhausen J, Frydrychowicz A, Sulkowski T, Balks MF, Buchholz M, Lohwasser S, Volker M, Goldschmidt O, Johenning A, Schlender S, Paulus C, Antoch G, Dettmer S, Baessler B, Maintz D, Pinto Dos Santos D, Vogl TJ, Hattingen E, Stoevesandt D, Reinartz S, Storz C, Muller-Peltzer K, Bamberg F, Rengier F, Weis M, Frisch A, Hansen NL, Kolb M, Maurer M, Nikolaou K, Afat S, Othman AE. CoRad-19 - Modulare Digitale Lehre während der SARS-CoV-2-Pandemie. Rofo 2022 DOI: 10.1055/a-1752-0624 Gerdes C, Reinecke J, Neeße A, Borggrefe J, Kröger JR. State of the Art Diagnostik des Ösophagus . Original-/übers. Titel: State of the Art Diagnostics of the Esophagus Ther Umsch 2022;79(3-4):121-131 DOI: 10.1024/0040-5930/a001338 Liu Z, Kilic G, Li W, Bulut O, Gupta MK, Zhang B, Qi C, Peng H, Tsay H, Soon CF. Multi-Omics Integration Reveals Only Minor Long-Term Molecular and Functional Sequelae in Immune Cells of Individuals Recovered From COVID-19. Front Immunol 2022;13:838132 DOI: 10.3389/fimmu.2022.838132 Dopfer-Jablonka A, Steffens S, Müller F, Mikuteit M, Niewolik J, Cossmann A, Stankov MV, Behrens GMN, Hummers E, Heesen G, Schröder D, Roder S, Klawonn F, Vahldiek K, Hasenkamp J, Kallusky J, Falk CS, Overbeck TR, Heinemann S. SARS-CoV-2-specific immune responses in elderly and immunosuppressed participants and patients with hematologic disease or checkpoint inhibition in solid tumors: study protocol of the prospective, observational CoCo immune study. BMC Infect Dis 2022;22(1):403 DOI: 10.1186/s12879-022-07347-w Becker J, Kalinke U. Toll-like receptors matter: plasmacytoid dendritic cells in COVID-19. EMBO J 2022:e111208 DOI: 10.15252/embj.2022111208 Arora P, Kempf A, Nehlmeier I, Graichen L, Winkler MS, Lier M, Schulz S, Jäck H, Cossmann A, Stankov MV, Behrens GMN, Pöhlmann S, Hoffmann M. SARS-CoV-2 variants C.1.2 and B.1.621 (Mu) partially evade neutralization by antibodies elicited upon infection or vaccination. Cell Rep 2022;39(5):110754 DOI: 10.1016/j.celrep.2022.110754 Bonifacius A, Tischer-Zimmermann S, Santamorena MM, Mausberg P, Schenk J, Koch S, Barnstorf-Brandes J, Gödecke N, Martens J, Goudeva L, Verboom M, Wittig J, Maecker-Kolhoff B, Baurmann H, Clark C, Brauns O, Simon M, Lang P, Cornely OA, Hallek M, Blasczyk R, Seiferling D, Köhler P, Eiz-Vesper B. Rapid Manufacturing of Highly Cytotoxic Clinical-Grade SARS-CoV-2-specific T Cell Products Covering SARS-CoV-2 and Its Variants for Adoptive T Cell Therapy. Front Bioeng Biotechnol 2022;10:867042 DOI: 10.3389/fbioe.2022.867042 Silenou BC, Verset C, Kaburi BB, Leuci O, Ghozzi S, Duboudin C, Krause G. A Novel Tool for Real-Time Estimation of Epidemiological Parameters of Communicable Diseases Using Contact-Tracing Data: Development and Deployment. JMIR Public Health Surveill 2022 DOI: 10.2196/34438 Mariani S, De Piero ME, Ravaux JM, Saelmans A, Kawczynski MJ, van Bussel, Bas C T, Di Mauro M, Willers A, Swol J, Kowalewski M, Li T, Delnoij TSR, van der Horst, Iwan C C, Maessen J, Lorusso R. Temporary mechanical circulatory support for COVID-19 patients: A systematic review of literature. Artif Organs 2022 DOI: 10.1111/aor.14261 Lee AJ, Feng E, Chew MV, Balint E, Poznanski SM, Giles E, Zhang A, Marzok A, Revill SD, Vahedi F, Dubey A, Ayaub E, Jimenez-Saiz R, McGrath JJC, Ritchie TM, Jordana M, Jonigk DD, Ackermann M, Ask K, Miller M, Richards CD, Ashkar AA. Type I interferon regulates proteolysis by macrophages to prevent immunopathology following viral infection. PLoS Pathog 2022;18(5):e1010471 DOI: 10.1371/journal.ppat.1010471 Müller F, Heinemann S, Hummers E, Noack EM, Heesen G, Dopfer-Jablonka A, Mikuteit M, Niewolik J, Steffens S, Schröder D. Impfeinstellung, Erwartungen und Impferfahrung von Immunsupprimierten bei COVID-19-Impfungen. Original-/übers. Titel: Immunosuppressed people's beliefs, expectations, and experiences with COVID-19 vaccinations : Results of a longitudinal study Z Rheumatol 2022 DOI: 10.1007/s00393-022-01213-5 Enengl S, Pecks U, Oppelt P, Stelzl P, Trautner PS, Shebl O, Lamprecht B, Longardt AC, Eckmann-Scholz C, Keil C, Mand N, von Kaisenberg CS, Jegen M, Doppler S, Lastinger J. Antibody Response and Maternofetal Antibody Transfer in SARS-CoV-2-Positive Pregnant Women: A Multicenter Observational Study. Geburtshilfe Frauenheilkd 2022;82(5):501-509 DOI: 10.1055/a-1768-0415 Rosendal E, Mihai IS, Becker M, Das D, Frängsmyr L, Persson BD, Rankin GD, Gröning R, Trygg J, Forsell M, Ankarklev J, Blomberg A, Henriksson J, Överby AK, Lenman A. Serine Protease Inhibitors Restrict Host Susceptibility to SARS-CoV-2 Infections. mBio 2022:e0089222 DOI: 10.1128/mbio.00892-22 Mentzer SJ, Ackermann M, Jonigk D. Endothelialitis, Microischemia, and Intussusceptive Angiogenesis in COVID-19. Cold Spring Harb Perspect Med 2022 DOI: 10.1101/cshperspect.a041157 Degen CV, Mikuteit M, Niewolik J, Schröder D, Vahldiek K, Mücke U, Heinemann S, Müller F, Behrens GMN, Klawonn F, Dopfer-Jablonka A, Steffens S. Self-reported Tinnitus and Vertigo or Dizziness in a Cohort of Adult Long COVID Patients. Front Neurol 2022;13:884002 DOI: 10.3389/fneur.2022.884002 Schroder D, Heesen G, Heinemann S, Hummers E, Jablonka A, Steffens S, Mikuteit M, Niewolik J, Overbeck TR, Kallusky J, Muller F. Development and Validation of a Questionnaire to Assess Social Participation of High Risk-Adults in Germany During the COVID-19 Pandemic. Front Public Health 2022;10:831087 DOI: 10.3389/fpubh.2022.831087 Reschke F, Galuschka L, Landsberg S, Weiner C, Guntermann C, Sadeghian E, Lange K, Danne T. Successful telehealth transformation of a pediatric outpatient obesity teaching program due to the COVID-19 pandemic - the "Video KiCK" program. J Pediatr Endocrinol Metab 2022 DOI: 10.1515/jpem-2022-0104 Kleinwechter HJ, Weber KS, Mingers N, Ramsauer B, Schaefer-Graf UM, Groten T, Kuschel B, Backes C, Banz-Jansen C, Berghaeuser MA, Brotsack IA, Dressler-Steinbach I, Engelbrecht C, Engler-Hauschild S, Gruber TM, Hepp V, Hollatz-Galuschki E, Iannaccone A, Jebens A, VON Kaisenberg CS, Kaup L, Keil C, Kladt C, Kolben T, Kraft K, Kunze M, Lastinger J, Luedemann K, Manz J, Morfeld CA, Parchmann O, Pfaff L, Reinhardt K, Runkel A, Schmidt M, Sourouni M, Stelbrink J, Stubert J, Stumpfe FM, Treptow A, Rudiger M, Pecks U, CRONOS Network. Gestational diabetes mellitus and COVID-19: results from the CRONOS study. Am J Obstet Gynecol 2022 DOI: 10.1016/j.ajog.2022.05.027 Arora P, Kempf A, Nehlmeier I, Graichen L, Schulz S, Cossmann A, Dopfer-Jablonka A, Winkler MS, Jack HM, Behrens GMN, Pohlmann S, Hoffmann M. Efficient antibody evasion but reduced ACE2 binding by the emerging SARS-CoV-2 variant B.1.640.2. Cell Mol Immunol 2022 DOI: 10.1038/s41423-022-00870-5 Welte T. Post-COVID Syndrome- More Questions Than Answers. Dtsch Arztebl Int 2022;119(10):165-166 DOI: 10.3238/arztebl.m2022.0154 Arora P, Zhang L, Kruger N, Rocha C, Sidarovich A, Schulz S, Kempf A, Graichen L, Moldenhauer AS, Cossmann A, Dopfer-Jablonka A, Behrens GMN, Jack HM, Pohlmann S, Hoffmann M. SARS-CoV-2 Omicron sublineages show comparable cell entry but differential neutralization by therapeutic antibodies. Cell Host Microbe 2022 DOI: 10.1016/j.chom.2022.04.017 Siegerist F, Hay E, Dikou JS, Pollheimer M, Buscher A, Oh J, Ribback S, Zimmermann U, Brasen JH, Lenoir O, Drenic V, Eller K, Tharaux PL, Endlich N. ScoMorphoFISH: A deep learning enabled toolbox for single-cell single-mRNA quantification and correlative (ultra-)morphometry. J Cell Mol Med 2022 DOI: 10.1111/jcmm.17392 Leidinger G, Flockerzi F, Hohneck J, Bohle RM, Fieguth A, Tschernig T. TRPC6 is altered in COVID-19 pneumonia. Chem Biol Interact 2022;362:109982 DOI: 10.1016/j.cbi.2022.109982 Louw C, Paffenholz R, Verset C, Krause G. Global Good Open Source Software Development in Response to the COVID-19 Pandemic - Perspectives from SORMAS Implementation in Europe. Stud Health Technol Inform 2022;294:669-673 DOI: 10.3233/SHTI220553 Prokosch HU, Bahls T, Bialke M, Eils J, Fegeler C, Gruendner J, Haarbrandt B, Hampf C, Hoffmann W, Hund H, Kampf M, Kapsner LA, Kasprzak P, Kohlbacher O, Krefting D, Mang JM, Marschollek M, Mate S, Muller A, Prasser F, Sass J, Semler S, Stenzhorn H, Thun S, Zenker S, Eils R. The COVID-19 Data Exchange Platform of the German University Medicine. Stud Health Technol Inform 2022;294:674-678 DOI: 10.3233/SHTI220554 Lasswitz L, Zapatero-Belinchón FJ, Moeller R, Hülskötter K, Laurent T, Carlson LA, Goffinet C, Simmons G, Baumgärtner W, Gerold G. The Tetraspanin CD81 Is a Host Factor for Chikungunya Virus Replication. mBio 2022:e0073122 DOI: 10.1128/mbio.00731-22 Gottlieb J, Kolditz M, Gade N, Welte T, Kneidinger N. Benefit of monoclonal antibodies in early treatment of COVID-19 after lung transplantation - a retrospective analysis in two centers. Eur Respir J 2022 DOI: 10.1183/13993003.00124-2022 de Buhr N, Baumann T, Werlein C, Fingerhut L, Imker R, Meurer M, Götz F, Bronzlik P, Kühnel MP, Jonigk DD, Ernst J, Leotescu A, Gabriel MM, Worthmann H, Lichtinghagen R, Tiede A, von Köckritz-Blickwede M, Falk CS, Weissenborn K, Schuppner R, Grosse GM. Insights Into Immunothrombotic Mechanisms in Acute Stroke due to Vaccine-Induced Immune Thrombotic Thrombocytopenia. Front Immunol 2022;13:879157 DOI: 10.3389/fimmu.2022.879157 Muzalyova A, Ebigbo A, Kahn M, Zellmer S, Beyer A, Rosendahl J, Zenk J, Al-Nawas B, Frankenberger R, Hoffmann J, Arens C, Lammert F, Traidl-Hoffmann C, Messmann H, Roemmele C. SARS-CoV-2 Vaccination Rate and SARS-CoV-2 Infection of Health Care Workers in Aerosol-Generating Medical Disciplines. J Clin Med 2022;11(10) DOI: 10.3390/jcm11102751 Kuijpers Y, Chu X, Jaeger M, Moorlag SJCFM, Koeken VACM, Zhang B, de Nooijer A, Grondman I, Gupta MK, Janssen N, Mourits VP, de Bree LCJ, de Mast Q, van de Veerdonk FL, Joosten LAB, Li Y, Netea MG, Xu CJ. The Genetic Risk for COVID-19 Severity Is Associated With Defective Immune Responses. Front Immunol 2022;13:859387 DOI: 10.3389/fimmu.2022.859387 Tegethoff SA, Danziger G, Kühn D, Kimmer C, Adams T, Heintz L, Metz C, Reifenrath K, Angresius R, Mang S, Rixecker T, Becker A, Geisel J, Jentgen C, Seiler F, Reichert MC, Fröhlich F, Meyer S, Rissland J, Ewen S, Wagenpfeil G, Last K, Smola S, Bals R, Lammert F, Becker SL, Krawczyk M, Lepper PM, Papan C. TRAIL, IP-10, and CRP in predicting the progression of SARS-CoV-2 infection: A prospective, cohort study. Int J Infect Dis 2022 DOI: 10.1016/j.ijid.2022.05.051 Haghi M, Benis A, M Deserno T. Accident & Emergency Informatics and One Digital Health. Yearb Med Inform 2022 DOI: 10.1055/s-0042-1742506 Hersh WR, Haux R, Huesing E, Ball MJ, Kimura M, Otero P, Detmer D, Koch S, Saranto KK, Wright G. The International Academy of Health Sciences Informatics: 2021 Update. Yearb Med Inform 2022 DOI: 10.1055/s-0042-1742501 Sorg A, Bergfeld L, Jank M, Corman V, Semmler I, Goertz A, Beyerlein A, Verjans E, Wagner N. Cross-sectional seroprevalence surveys of SARS-CoV-2 antibodies in children in Germany, June 2020 to May 2021. Nat Commun 2022;13(1):3128 DOI: 10.1038/s41467-022-30482-6 Kuhlmann E, Behrens GMN, Cossmann A, Homann S, Happle C, Dopfer-Jablonka A. Healthcare Workers' Perceptions and Medically Approved COVID-19 Infection Risk: Understanding the Mental Health Dimension of the Pandemic. A German Hospital Case Study. Front Public Health 2022;10:898840 DOI: 10.3389/fpubh.2022.898840 Wulff A, Biermann P, von Landesberger T, Baumgartl T, Schmidt C, Alhaji AY, Schick K, Waldstein P, Zhu Y, HiGHmed Infection Control Study Group, Krefting D, Scheithauer S, Marschollek M. Tracing COVID-19 Infection Chains Within Healthcare Institutions - Another Brick in the Wall Against SARS-CoV-2. Stud Health Technol Inform 2022;290:699-703 DOI: 10.3233/SHTI220168 Scutelnic A, Krzywicka K, Mbroh J, van de Munckhof A, Sanchez van Kammen M, Aguiar de Sousa D, Lindgren E, Jood K, Gunther A, Hiltunen S, Putaala J, Tiede A, Maier F, Kern R, Bartsch T, Althaus K, Ciccone A, Wiedmann M, Skjelland M, Medina A, Cuadrado-Godia E, Cox T, Aujayeb A, Raposo N, Garambois K, Payen JF, Vuillier F, Franchineau G, Timsit S, Bougon D, Dubois MC, Tawa A, Tracol C, De Maistre E, Bonneville F, Vayne C, Mengel A, Michalski D, Pelz J, Wittstock M, Bode F, Zimmermann J, Schouten J, Buture A, Murphy S, Palma V, Negro A, Gutschalk A, Nagel S, Schoenenberger S, Frisullo G, Zanferrari C, Grillo F, Giammello F, Martin MM, Cervera A, Burrow J, Garcia Esperon C, Chew BLA, Kleinig TJ, Soriano C, Zimatore DS, Petruzzellis M, Elkady A, Miranda MS, Fernandes J, Hellstrom Vogel A, Johansson E, Philip AP, Coutts SB, Bal S, Buck B, Legault C, Blacquiere D, Katzberg HD, Field TS, Dizonno V, Gattringer T, Jacobi C, Devroye A, Lemmens R, Kristoffersen ES, Bandettini di Poggio M, Ghiasian M, Karapanayiotides T, Chatterton S, Wronski M, Ng K, Kahnis R, Geeraerts T, Reiner P, Cordonnier C, Middeldorp S, Levi M, van Gorp ECM, van de Beek D, Brodard J, Kremer Hovinga JA, Kruip MJHA, Tatlisumak T, Ferro JM, Coutinho JM, Arnold M, Poli S, Heldner MR. Management of cerebral venous thrombosis due to adenoviral COVID-19 vaccination. Ann Neurol 2022 DOI: 10.1002/ana.26431 Zeidler H, Hudson AP. Quo vadis reactive arthritis? Curr Opin Rheumatol 2022;34(4):218-224 DOI: 10.1097/BOR.0000000000000880 Harke NN, Wagner C, Hermann RM, Hadaschik BA, Radtke JP, Altay-Langguth A, Aufderklamm S, Bach C, Becker-Schiebe M, Blana A, Bruns F, Buse S, Combs SE, Engels CL, Ezzibdeh E, Fiedler M, Fischer LA, Farzat M, Frismann A, Heck MM, Henkenberens C, Roesch MC, Kading C, Klautke G, Krausewitz P, Kuczyk MA, Leitsmann C, Lettmaier S, Mahjoub S, Manseck A, Medenwald D, Meyer A, Micke O, Moritz R, Ott M, Peters I, Pokupic S, Porres D, Preisser F, Reichel K, Schneider A, Schwentner C, Scobioala S, Truss M, Wegener D, Wezel F, Willborn K, Witt JH, Wittig A, Wittlinger M, Wolff HA, Zimmermanns V, Christiansen H. Lessons learned after one year of COVID-19 from a urologist and radiotherapist view: A German survey on prostate cancer diagnosis and treatment. PLoS One 2022;17(6):e0269827 DOI: 10.1371/journal.pone.0269827 Roche N, Crichton ML, Goeminne PC, Cao B, Humbert M, Shteinberg M, Antoniou KM, Suppli Ulrik C, Parks H, Wang C, Vandendriessche T, Qu J, Stolz D, Brightling C, Welte T, Aliberti S, Simonds AK, Tonia T, Chalmers JD. Update March 2022: management of hospitalised adults with coronavirus disease-19 (COVID-19): a european respiratory society living guideline. Eur Respir J 2022 DOI: 10.1183/13993003.00803-2022 Joean O, Welte T. Vaccination and modern management of chronic obstructive pulmonary disease - a narrative review. Expert Rev Respir Med 2022 DOI: 10.1080/17476348.2022.2092099 Worm M, Alexiou A, Bauer A, Treudler R, Wurpts G, Dickel H, Buhl T, Müller S, Jung A, Brehler R, Fluhr J, Klimek L, Mülleneisen N, Pfützner W, Raap U, Roeseler S, Schuh S, Timmermann H, Heine G, Wedi B, Brockow K. Management of suspected and confirmed COVID-19 (SARS-CoV-2) vaccine hypersensitivity. Allergy 2022 DOI: 10.1111/all.15414 Baier C, Huang J, Reumann K, Indenbirken D, Thol F, Koenecke C, Ebadi E, Heim A, Bange FC, Haid S, Pietschmann T, Fischer N. Target capture sequencing reveals a monoclonal outbreak of respiratory syncytial virus B infections among adult hematologic patients. Antimicrob Resist Infect Control 2022;11(1):88 DOI: 10.1186/s13756-022-01120-z Schröder D, Heinemann S, Heesen G, Klawonn F, Mikuteit M, Niewolik J, Steffens S, Behrens G, Jablonka A, Müller F. Who is pausing immunosuppressive medication for COVID-19 vaccination? Results of an exploratory observational trial. Eur J Med Res 2022;27(1):97 DOI: 10.1186/s40001-022-00727-7 Haier J, Beller J, Adorjan K, Bleich S, De Greck M, Griesinger F, Hein A, Hurlemann R, Mees ST, Philipsen A, Rohde G, Schilling G, Trautmann K, Combs SE, Geyer S, Schafers J. Decision Conflicts in Clinical Care during COVID-19: A Patient Perspective. Healthcare (Basel) 2022;10(6):1019 DOI: 10.3390/healthcare10061019 Heesen G, Schröder D, Müller F, Hummers E, Klawonn F, Mikuteit M, Niewolik J, Steffens S, Cossmann A, Behrens G, Dopfer-Jablonka A, Heinemann S. The Impact of COVID-19 Vaccination on the Social Participation of Immunocompromised Persons - Results of a Multicenter Observational Study. Front Public Health 2022;10:877623 DOI: 10.3389/fpubh.2022.877623 Lasch F, Guizzaro L. Estimators for handling COVID-19-related intercurrent events with a hypothetical strategy. Pharm Stat 2022 DOI: 10.1002/pst.2244 Al-Mustapha AI, Okechukwu O, Olayinka A, Muhammed OR, Oyewo M, Owoicho SA, Abubakar AT, Olabisi A, Jibril A, Ereh S, Fakayode OE, Ogundijo OA, Elelu N, Adetunji VO. A national survey of COVID-19 vaccine acceptance in Nigeria. Vaccine 2022 DOI: 10.1016/j.vaccine.2022.06.050 Herrmann J, Lotz C, Karagiannidis C, Weber-Carstens S, Kluge S, Putensen C, Wehrfritz A, Schmidt K, Ellerkmann RK, Oswald D, Lotz G, Zotzmann V, Moerer O, Kühn C, Kochanek M, Muellenbach R, Gaertner M, Fichtner F, Brettner F, Findeisen M, Heim M, Lahmer T, Rosenow F, Haake N, Lepper PM, Rosenberger P, Braune S, Kohls M, Heuschmann P, Meybohm P. Key characteristics impacting survival of COVID-19 extracorporeal membrane oxygenation. Crit Care 2022;26(1):190 DOI: 10.1186/s13054-022-04053-6 Bandyopadhyay A, Schips M, Mitra T, Khailaie S, Binder SC, Meyer-Hermann M. Testing and isolation to prevent overloaded healthcare facilities and reduce death rates in the SARS-CoV-2 pandemic in Italy. Commun Med (Lond) 2022;2:75 DOI: 10.1038/s43856-022-00139-y Arora P, Kempf A, Nehlmeier I, Schulz SR, Cossmann A, Stankov MV, Jäck H, Behrens GMN, Pöhlmann S, Hoffmann M. Augmented neutralisation resistance of emerging omicron subvariants BA.2.12.1, BA.4, and BA.5. Lancet Infect Dis 2022 DOI: 10.1016/S1473-3099(22)00422-4 Twele F, Ten Hagen NA, Meller S, Schulz C, Osterhaus A, Jendrny P, Ebbers H, Pink I, Drick N, Welte T, Schalke E, Volk HA. Detection of Post-COVID-19 Patients Using Medical Scent Detection Dogs-A Pilot Study. Front Med (Lausanne) 2022;9:877259 DOI: 10.3389/fmed.2022.877259 Natanov R, Kunkel ER, Wiesner O, Haverich A, Wiegmann B, Rümke S, Kühn C. Determinants of survival in patients on extracorporeal membrane oxygenation therapy due to severe covid-19. Perfusion 2022:2676591221113135 DOI: 10.1177/02676591221113135 Publications with the PMID: 35787726 - 37068591 Wendel-Garcia P, Moser A, Jeitziner M, Aguirre-Bermeo H, Arias-Sanchez P, Apolo J, Roche-Campo F, Franch-Llasat D, Kleger G, Schrag C, Pietsch U, Filipovic M, David S, Stahl K, Bouaoud S, Ouyahia A, Fodor P, Locher P, Siegemund M, Zellweger N, Cereghetti S, Schott P, Gangitano G, Wu MA, Alfaro-Farias M, Vizmanos-Lamotte G, Ksouri H, Gehring N, Rezoagli E, Turrini F, Lozano-Gómez H, Carsetti A, Rodríguez-García R, Yuen B, Weber AB, Castro P, Escos-Orta J, Dullenkopf A, Martín-Delgado MC, Aslanidis T, Perez M, Hillgaertner F, Ceruti S, Franchitti Laurent M, Marrel J, Colombo R, Laube M, Fogagnolo A, Studhalter M, Wengenmayer T, Gamberini E, Buerkle C, Buehler PK, Keiser S, Elhadi M, Montomoli J, Guerci P, Fumeaux T, Schuepbach RA, Jakob SM, Que Y, Hilty MP, Hilty MP, Wendel-Garcia P, Schuepbach RA, Montomoli J, Guerci P, Fumeaux T, Bouaoud S, Ouyahia A, Abdoun M, Rais M, Alfaro-Farias M, Vizmanos-Lamotte G, Caballero A, Tschoellitsch T, Meier J, Aguirre-Bermeo H, Arias-Sanchez P, Apolo J, Martinez LA, Tirapé-Castro H, Galal I, Tharwat S, Abdehaleem I, Jurkolow G, Guerci P, Novy E, Losser M, Wengenmayer T, Zotzmann V, David S, Stahl K, Seeliger B, Welte T, Aslanidis T, Korsos A, Ahmed LA, Hashim HT, Nikandish R, Carsetti A, Casarotta E, Giaccaglia P, Rezoagli E, Giacomini M, Magliocca A, Bolondi G, Potalivo A, Fogagnolo A, Salvi L, Wu MA, Cogliati C, Colombo R, Catena E, Turrini F, Simonini MS, Fabbri S, Montomoli J, Gamberini E, Gangitano G, Bitondo MM, Maciopinto F, de Camillis E, Venturi M, Bocci MG, Antonelli M, Alansari A, Abusalama A, Omar O, Binnawara M, Alameen H, Elhadi M, Alhadi A, Arhaym A, Gommers D, Ince C, Jayyab M, Alsharif M, Rodríguez-García R, Gámez-Zapata J, Taboada-Fraga X, Castro P, Fernandez J, Reverter E, Lander-Azcona A, Escós-Orta J, Martín-Delgado MC, Algaba-Calderon A, Roche-Campo F, Franch-Llasat D, Concha P, Sauras-Colón E, Lozano-Gómez H, Zalba-Etayo B, Montes MP, Michot MP, Klarer A, Ensner R, Schott P, Urech S, Siegemund M, Zellweger N, Gebhard CE, Hollinger A, Merki L, Lambert A, Laube M, Jeitziner MM, Moser A, Que Y, Jakob SM, Wiegand J, Yuen B, Lienhardt-Nobbe B, Westphalen A, Salomon P, Hillgaertner F, Sieber M, Dullenkopf A, Barana G, Ksouri H, Sridharan GO, Cereghetti S, Boroli F, Pugin J, Grazioli S, Bürkle C, Marrel J, Brenni M, Fleisch I, Perez M, Ramelet A, Weber AB, Gerecke P, Christ A, Ceruti S, Glotta A, Biggiogero M, Marquardt K, Hübner T, Neff T, Redecker H, Fumeaux T, Moret-Bochatay M, Betello M, zu Bentrup FM, Studhalter M, Stephan M, Gehring N, Selz D, Kleger G, Schrag C, Pietsch U, Filipovic M, Ristic A, Heise A, Franchitti Laurent M, Laurent J, Gaspert T, Haberthuer C, Fodor P, Locher P, Garcia PDW, Hilty MP, Schuepbach R, Keiser S, Heuberger D, Bartussek J, Bühler P, Brugger S, Kleinert E, Fehlbier K, Danial A, Almousa M, Abdulbaki Y, Sannah K, Colak E, Marczin N, Al-Ameri S, the RISC-19-ICU Investigators. Dynamics of disease characteristics and clinical management of critically ill COVID-19 patients over the time course of the pandemic: an analysis of the prospective, international, multicentre RISC-19-ICU registry. Crit Care 2022;26(1):199 DOI: 10.1186/s13054-022-04065-2 Wittig A, Miranda F, Hölzer M, Altenburg T, Bartoszewicz JM, Beyvers S, Dieckmann MA, Genske U, Giese SH, Nowicka M, Richard H, Schiebenhoefer H, Schmachtenberg A, Sieben P, Tang M, Tembrockhaus J, Renard BY, Fuchs S. CovRadar: Continuously tracking and filtering SARS-CoV-2 mutations for genomic surveillance. Bioinformatics 2022 DOI: 10.1093/bioinformatics/btac411 Baumeier C, Aleshcheva G, Harms D, Gross U, Hamm C, Assmus B, Westenfeld R, Kelm M, Rammos S, Wenzel P, Munzel T, Elsasser A, Gailani M, Perings C, Bourakkadi A, Flesch M, Kempf T, Bauersachs J, Escher F, Schultheiss HP. Intramyocardial Inflammation after COVID-19 Vaccination: An Endomyocardial Biopsy-Proven Case Series. Int J Mol Sci 2022;23(13):6940 DOI: 10.3390/ijms23136940 Grossi PA, Kamar N, Saliba F, Baldanti F, Aguado JM, Gottlieb J, Banas B, Potena L. Cytomegalovirus Management in Solid Organ Transplant Recipients: A Pre-COVID-19 Survey From the Working Group of the European Society for Organ Transplantation. Transpl Int 2022;35:10332 DOI: 10.3389/ti.2022.10332 Dimitriadis K, Meis J, Neugebauer H, Barlinn K, Neumann B, Gahn G, Lochner P, Knier B, Lindemann S, Suhs KW, Szabo K, Pfefferkorn T, Schirotzek I, Freilinger T, Burc B, Gunther A, Wittstock M, Schramm P, Reimann G, Godau J, Nagy G, Koenig FB, Essig F, Klinker H, Hartmann C, Schmidbauer ML, Steinberg T, Lefterova L, Klose C, Bosel J, IGNITE study group. Neurologic manifestations of COVID-19 in critically ill patients: results of the prospective multicenter registry PANDEMIC. Crit Care 2022;26(1):217 DOI: 10.1186/s13054-022-04080-3 Bucher F, Dastagir K, Obed D, Dieck T, Vogt PM. Sustained high demand for intensive care unit resources for the treatment of burn patients during the COVID-19 pandemic in Northern Germany: A single-centre cross-sectional study. JPRAS Open 2022 DOI: 10.1016/j.jpra.2022.07.002 Indolfi G, Czubkowski P, Fitzpatrick E, Gonzales E, Gupte G, Mancell S, Mozer-Glassberg Y, Nicastro E, Norman J, Stephenne X, Zellos A, Samyn M. Acute Hepatitis of Unknown Aetiology Among Young Children: Research Agenda by the ESPGHAN Hepatology Committee. J Pediatr Gastroenterol Nutr 2022 DOI: 10.1097/MPG.0000000000003567 Degenhardt F, Ellinghaus D, Juzenas S, Lerga-Jaso J, Wendorff M, Maya-Miles D, Uellendahl-Werth F, ElAbd H, Ruhlemann MC, Arora J, Ozer O, Lenning OB, Myhre R, Vadla MS, Wacker EM, Wienbrandt L, Ortiz AB, Salazar A, Chercoles AG, Palom A, Ruiz A, Garcia-Fernandez AE, Blanco-Grau A, Mantovani A, Zanella A, Holten AR, Mayer A, Bandera A, Cherubini A, Protti A, Aghemo A, Gerussi A, Ramirez A, Braun A, Nebel A, Barreira A, Lleo A, Teles A, Kildal AB, Biondi A, Caballero-Garralda A, Ganna A, Gori A, Gluck A, Lind A, Tanck A, Hinney A, Nolla AC, Fracanzani AL, Peschuck A, Cavallero A, Dyrhol-Riise AM, Ruello A, Julia A, Muscatello A, Pesenti A, Voza A, Rando-Segura A, Solier A, Schmidt A, Cortes B, Mateos B, Nafria-Jimenez B, Schaefer B, Jensen B, Bellinghausen C, Maj C, Ferrando C, Horra C, Quereda C, Skurk C, Thibeault C, Scollo C, Herr C, Spinner CD, Gassner C, Lange C, Hu C, Paccapelo C, Lehmann C, Angelini C, Cappadona C, Azuure C, COVICAT study group, Aachen Study (COVAS), Bianco C, Cea C, Sancho C, Hoff DAL, Galimberti D, Prati D, Haschka D, Jimenez D, Pestana D, Toapanta D, Muniz-Diaz E, Azzolini E, Sandoval E, Binatti E, Scarpini E, Helbig ET, Casalone E, Urrechaga E, Paraboschi EM, Pontali E, Reverter E, Calderon EJ, Navas E, Solligard E, Contro E, Arana-Arri E, Aziz F, Garcia F, Sanchez FG, Ceriotti F, Martinelli-Boneschi F, Peyvandi F, Kurth F, Blasi F, Malvestiti F, Medrano FJ, Mesonero F, Rodriguez-Frias F, Hanses F, Muller F, Hemmrich-Stanisak G, Bellani G, Grasselli G, Pezzoli G, Costantino G, Albano G, Cardamone G, Bellelli G, Citerio G, Foti G, Lamorte G, Matullo G, Baselli G, Kurihara H, Neb H, My I, Kurth I, Hernandez I, Pink I, Rojas I, Galvan-Femenia I, Holter JC, Afset JE, Heyckendorf J, Kassens J, Damas JK, Rybniker J, Altmuller J, Ampuero J, Martin J, Erdmann J, Banales JM, Badia JR, Dopazo J, Schneider J, Bergan J, Barretina J, Walter J, Quero JH, Goikoetxea J, Delgado J, Guerrero JM, Fazaal J, Kraft J, Schroder J, Risnes K, Banasik K, Muller KE, Gaede KI, Garcia-Etxebarria K, Tonby K, Heggelund L, Izquierdo-Sanchez L, Bettini LR, Sumoy L, Sander LE, Lippert LJ, Terranova L, Nkambule L, Knopp L, Gustad LT, Garbarino L, Santoro L, Tellez L, Roade L, Ostadreza M, Intxausti M, Kogevinas M, Riveiro-Barciela M, Berger MM, Schaefer M, Niemi MEK, Gutierrez-Stampa MA, Carrabba M, Figuera Basso ME, Valsecchi MG, Hernandez-Tejero M, Vehreschild MJGT, Manunta M, Acosta-Herrera M, D'Angio M, Baldini M, Cazzaniga M, Grimsrud MM, Cornberg M, Nothen MM, Marquie M, Castoldi M, Cordioli M, Cecconi M, D'Amato M, Augustin M, Tomasi M, Boada M, Dreher M, Seilmaier MJ, Joannidis M, Wittig M, Mazzocco M, Ciccarelli M, Rodriguez-Gandia M, Bocciolone M, Miozzo M, Ayo NI, Blay N, Chueca N, Montano N, Braun N, Ludwig N, Marx N, Martinez N, Norwegian SARS-CoV-2 Study group, Cornely OA, Witzke O, Palmieri O, Pa Study Group, Faverio P, Preatoni P, Bonfanti P, Omodei P, Tentorio P, Castro P, Rodrigues PM, Espana PP, Hoffmann P, Rosenstiel P, Schommers P, Suwalski P, Pablo R, Ferrer R, Bals R, Gualtierotti R, Gallego-Duran R, Nieto R, Carpani R, Morilla R, Badalamenti S, Haider S, Ciesek S, May S, Bombace S, Marsal S, Pigazzini S, Klein S, Pelusi S, Wilfling S, Bosari S, Volland S, Brunak S, Raychaudhuri S, Schreiber S, Heilmann-Heimbach S, Aliberti S, Ripke S, Dudman S, Wesse T, Zheng T, STORM Study group, The Humanitas Task Force, The Humanitas Gavazzeni Task Force, Bahmer T, Eggermann T, Illig T, Brenner T, Pumarola T, Feldt T, Folseraas T, Cejudo TG, Landmesser U, Protzer U, Hehr U, Rimoldi V, Monzani V, Skogen V, Keitel V, Kopfnagel V, Friaza V, Andrade V, Moreno V, Albrecht W, Peter W, Poller W, Farre X, Yi X, Wang X, Khodamoradi Y, Karadeniz Z, Latiano A, Goerg S, Bacher P, Koehler P, Tran F, Zoller H, Schulte EC, Heidecker B, Ludwig KU, Fernandez J, Romero-Gomez M, Albillos A, Invernizzi P, Buti M, Duga S, Bujanda L, Hov JR, Lenz TL, Asselta R, Cid R, Valenti L, Karlsen TH, Caceres M, Franke A. Detailed stratified GWAS analysis for severe COVID-19 in four European populations. Hum Mol Genet 2022 DOI: 10.1093/hmg/ddac158 Nordhorn I, Weiss D, Werfel T, Zink A, Schielein MC, Traidl S. The impact of the first COVID-19 wave on office-based dermatological care in Germany: a focus on diagnosis, therapy and prescription of biologics. Eur J Dermatol 2022;32(2):195-206 DOI: 10.1684/ejd.2022.4222 Griese M, Kappler M, Stehling F, Schulze J, Baden W, Koerner-Rettberg C, Carlens J, Prenzel F, Nahrlich L, Thalmeier A, Sebah D, Kronfeld K, Rock H, Ruckes C, HCQ-study group, Wetzke M, Seidl E, Schwerk N. Randomized controlled phase 2 trial of hydroxychloroquine in childhood interstitial lung disease. Orphanet J Rare Dis 2022;17(1):289 DOI: 10.1186/s13023-022-02399-2 Rommele C, Kahn M, Zellmer S, Muzalyova A, Hammel G, Bartenschlager C, Beyer A, Rosendahl J, Schlittenbauer T, Zenk J, Al-Nawas B, Frankenberger R, Hoffmann J, Arens C, Lammert F, Traidl-Hoffmann C, Messmann H, Ebigbo A. Risikofaktoren für SARS-CoV-2-Infektionen bei medizinischem Personal in aerosol-generierenden Disziplinen. Z Gastroenterol 2022 DOI: 10.1055/a-1845-2979 Original-/übers. Titel: Factors associated with an increased risk of SARS-CoV-2 infection in healthcare workers in aerosol-generating disciplines Karagiannis F, Peukert K, Surace L, Michla M, Nikolka F, Fox M, Weiss P, Feuerborn C, Maier P, Schulz S, Al B, Seeliger B, Welte T, David S, Grondman I, de Nooijer AH, Pickkers P, Kleiner JL, Berger MM, Brenner T, Putensen C, Bonn COVIMMUNE Consortium, Kato H, Garbi N, Netea MG, Hiller K, Placek K, Bode C, Wilhelm C. Impaired ketogenesis ties metabolism to T cell dysfunction in COVID-19. Nature 2022 DOI: 10.1038/s41586-022-05128-8 Rosa L, Godwin HJ, Cortese S, Brandt V. Predictors of longer-term depression trajectories during the COVID-19 pandemic: a longitudinal study in four UK cohorts. Evid Based Ment Health 2022 DOI: 10.1136/ebmental-2022-300461 Schons M, Pilgram L, Reese JP, Stecher M, Anton G, Appel KS, Bahmer T, Bartschke A, Bellinghausen C, Bernemann I, Brechtel M, Brinkmann F, Brunn C, Dhillon C, Fiessler C, Geisler R, Hamelmann E, Hansch S, Hanses F, Hanss S, Herold S, Heyder R, Hofmann AL, Hopff SM, Horn A, Jakob C, Jiru-Hillmann S, Keil T, Khodamoradi Y, Kohls M, Kraus M, Krefting D, Kunze S, Kurth F, Lieb W, Lippert LJ, Lorbeer R, Lorenz-Depiereux B, Maetzler C, Miljukov O, Nauck M, Pape D, Puntmann V, Reinke L, Rommele C, Rudolph S, Sass J, Schafer C, Schaller J, Schattschneider M, Scheer C, Scherer M, Schmidt S, Schmidt J, Seibel K, Stahl D, Steinbeis F, Stork S, Tauchert M, Tebbe JJ, Thibeault C, Toepfner N, Ungethum K, Vadasz I, Valentin H, Wiedmann S, Zoller T, Nagel E, Krawczak M, von Kalle C, Illig T, Schreiber S, Witzenrath M, Heuschmann P, Vehreschild JJ, NAPKON Research Group. The German National Pandemic Cohort Network (NAPKON): rationale, study design and baseline characteristics. Eur J Epidemiol 2022 DOI: 10.1007/s10654-022-00896-z Schwarz S, Lang C, Harlander M, Stupnik T, Slambrouck JV, Ceulemans LJ, Ius F, Gottlieb J, Kuhnert S, Hecker M, Aigner C, Kneidinger N, Verschuuren EA, Smits JM, Tschernko E, Schaden E, Faybik P, Markstaller K, Trauner M, Jaksch P, Hoetzenecker K. Gamma-glutamyltransferase is a strong predictor of secondary sclerosing cholangitis after lung transplantation for COVID-19 ARDS. J Heart Lung Transplant 2022 DOI: 10.1016/j.healun.2022.06.020 Schulte H, Schmiedl A, Muhlfeld C, Knudsen L. Teaching gross anatomy during the Covid-19 pandemic: Effects on medical students' gain of knowledge, confidence levels and pandemic-related concerns. Ann Anat 2022:151986 DOI: 10.1016/j.aanat.2022.151986 Pink I, Welte T. Häufigkeit, Spektrum und Risikofaktoren von Long-COVID. Inn Med (Heidelb) 2022;63(8):813-818 DOI: 10.1007/s00108-022-01370-4 Original-/übers. Titel: Frequency, spectrum and risk factors of long COVID Haier J, Mayer M, Schaefers J, Geyer S, Feldner D. A pyramid model to describe changing decision making under high uncertainty during the COVID-19 pandemic. BMJ Glob Health 2022;7(8):e008854 DOI: 10.1136/bmjgh Seeliger B. Intrakranielle Blutungen unter extrakorporaler Membranoxygenierung : Unterschiede zwischen COVID-19 und anderen viralen akuten respiratorischen Distress-Syndromen. Med Klin Intensivmed Notfmed 2022;117(6):476-478 DOI: 10.1007/s00063-022-00947-z Original-/übers. Titel: Intracranial hemorrhage under extracorporeal membrane oxygenation : Differences between COVID-19 and other viral acute respiratory distress syndromes Behrens GMN, Barros-Martins J, Cossmann A, Ramos GM, Stankov MV, Odak I, Dopfer-Jablonka A, Hetzel L, Kohler M, Patzer G, Binz C, Ritter C, Friedrichsen M, Schultze-Florey C, Ravens I, Willenzon S, Bubke A, Ristenpart J, Janssen A, Ssebyatika G, Krahling V, Bernhardt G, Hoffmann M, Pohlmann S, Krey T, Bosnjak B, Hammerschmidt SI, Forster R. BNT162b2-boosted immune responses six months after heterologous or homologous ChAdOx1nCoV-19/BNT162b2 vaccination against COVID-19. Nat Commun 2022;13(1):4872 DOI: 10.1038/s41467-022-32527-2 Degen CV, Mikuteit M, Niewolik J, Joosten T, Schröder D, Vahldiek K, Mücke U, Heinemann S, Müller F, Behrens GMN, Klawonn F, Lenarz T, Dopfer-Jablonka A, Steffens S. Audiological profile of adult Long COVID patients. Am J Otolaryngol 2022;43(5):103579 DOI: 10.1016/j.amjoto.2022.103579 Jacobsen H, Cobos Jimenez V, Sitaras I, Bar-Zeev N, Cicin-Sain L, Higdon MM, Deloria-Knoll M. Post-vaccination T cell immunity to omicron. Front Immunol 2022;13:944713 DOI: 10.3389/fimmu.2022.944713 de Rooij LPMH, Becker LM, Teuwen LA, Boeckx B, Jansen S, Feys S, Verleden S, Liesenborghs L, Stalder AK, Libbrecht S, Van Buyten T, Philips G, Subramanian A, Dumas SJ, Meta E, Borri M, Sokol L, Dendooven A, Truong ACK, Gunst J, Van Mol P, Haslbauer JD, Rohlenova K, Menter T, Boudewijns R, Geldhof V, Vinckier S, Amersfoort J, Wuyts W, Van Raemdonck D, Jacobs W, Ceulemans LJ, Weynand B, Thienpont B, Lammens M, Kuehnel M, Eelen G, Dewerchin M, Schoonjans L, Jonigk D, van Dorpe J, Tzankov A, Wauters E, Mazzone M, Neyts J, Wauters J, Lambrechts D, Carmeliet P. The pulmonary vasculature in lethal COVID-19 and idiopathic pulmonary fibrosis at single cell resolution. Cardiovasc Res 2022 DOI: 10.1093/cvr/cvac139 Aznaourova M, Schmerer N, Janga H, Zhang Z, Pauck K, Bushe J, Volkers SM, Wendisch D, Georg P, Ntini E, Aillaud M, Gündisch M, Mack E, Skevaki C, Keller C, Bauer C, Bertrams W, Marsico A, Nist A, Stiewe T, Gruber AD, Ruppert C, Li Y, Garn H, Sander LE, Schmeck B, Schulte LN. Single-cell RNA sequencing uncovers the nuclear decoy lincRNA PIRAT as a regulator of systemic monocyte immunity during COVID-19. Proc Natl Acad Sci U S A 2022;119(36):e2120680119 DOI: 10.1073/pnas.2120680119 Zeidler H. Geschichte der reaktiven Arthritis. Historische Meilensteine und Zukunft. Z Rheumatol 2022 DOI: 10.1007/s00393-022-01253-x Original-/übers. Titel: History of reactive arthritis. Historical milestones and future Homann S, Mikuteit M, Niewolik J, Behrens GMN, Stolting A, Muller F, Schroder D, Heinemann S, Mullenmeister C, El-Sayed I, Happle C, Steffens S, Dopfer-Jablonka A. Effects of Pre-Existing Mental Conditions on Fatigue and Psychological Symptoms Post-COVID-19. Int J Environ Res Public Health 2022;19(16):9924 DOI: 10.3390/ijerph19169924 Panagiota V, Dobbelstein C, Werwitzke S, Ganser A, Cooper N, Sachs UJ, Tiede A. Long-Term Outcomes after Vaccine-Induced Thrombotic Thrombocytopenia. Viruses 2022;14(8):1702 DOI: 10.3390/v14081702 Fineberg NA, Menchon JM, Hall N, Dell'Osso B, Brand M, Potenza MN, Chamberlain SR, Cirnigliaro G, Lochner C, Billieux J, Demetrovics Z, Rumpf HJ, Muller A, Castro-Calvo J, Hollander E, Burkauskas J, Grunblatt E, Walitza S, Corazza O, King DL, Stein DJ, Grant JE, Pallanti S, Bowden-Jones H, Ameringen MV, Ioannidis K, Carmi L, Goudriaan AE, Martinotti G, Sales CMD, Jones J, Gjoneska B, Kiraly O, Benatti B, Vismara M, Pellegrini L, Conti D, Cataldo I, Riva GM, Yucel M, Flayelle M, Hall T, Griffiths M, Zohar J. Advances in problematic usage of the internet research - A narrative review by experts from the European network for problematic usage of the internet. Compr Psychiatry 2022;118:152346 DOI: 10.1016/j.comppsych.2022.152346 Deterding R, Young LR, DeBoer EM, Warburton D, Cunningham S, Schwerk N, Flaherty KR, Brown KK, Dumistracel M, Erhardt E, Bertulis J, Gahlemann M, Stowasser S, Griese M. Nintedanib in children and adolescents with fibrosing interstitial lung diseases. Eur Respir J 2022:2201512 Nickel S, Bremer K, Dierks ML, Haack M, Wittmar S, Borgetto B, Kofahl C. Digitization in health-related self-help - Results of an online survey among self-help organizations in Germany. Digit Health 2022;8:20552076221120726 DOI: 10.1177/20552076221120726 Staessen JA, Wendt R, Yu YL, Kalbitz S, Thijs L, Siwy J, Raad J, Metzger J, Neuhaus B, Papkalla A, von der Leyen H, Mebazaa A, Dudoignon E, Spasovski G, Milenkova M, Canevska-Taneska A, Salgueira Lazo M, Psichogiou M, Rajzer MW, Fulawka L, Dzitkowska-Zabielska M, Weiss G, Feldt T, Stegemann M, Normark J, Zoufaly A, Schmiedel S, Seilmaier M, Rumpf B, Banasik M, Krajewska M, Catanese L, Rupprecht HD, Czerwienska B, Peters B, Nilsson A, Rothfuss K, Lubbert C, Mischak H, Beige J, CRIT-CoV-U investigators. Predictive performance and clinical application of COV50, a urinary proteomic biomarker in early COVID-19 infection: a prospective multicentre cohort study. Lancet Digit Health 2022 DOI: 10.1016/S2589-7500(22)00150-9 Karabatsiakis A, de Punder K, Salinas-Manrique J, Todt M, Dietrich DE. Hair cortisol level might be indicative for a 3PM approach towards suicide risk assessment in depression: comparative analysis of mentally stable and depressed individuals versus individuals after completing suicide. EPMA J 2022;13(3):383-395 DOI: 10.1007/s13167-022-00296-z Eckardt L, Doldi F, Busch S, Duncker D, Estner H, Kuniss M, Metzner A, Meyer C, Neuberger HR, Tilz R, Voss F, Steven D, Sommer P. 10-year follow-up of interventional electrophysiology: updated German survey during the COVID-19 pandemic. Clin Res Cardiol 2022 DOI: 10.1007/s00392-022-02090-3 Haier J, Beller J, Adorjan K, Bleich S, de Greck M, Griesinger F, Heppt MV, Hurlemann R, Mees ST, Philipsen A, Rohde G, Schilling G, Trautmann K, Combs SE, Geyer S, Schaefers J. Differences in Stakeholders' Perception of the Impact of COVID-19 on Clinical Care and Decision-Making. Cancers (Basel) 2022;14(17):4317 DOI: 10.3390/cancers14174317 Feltgen N, Ach T, Ziemssen F, Quante CS, Gross O, Abdin AD, Aisenbrey S, Bartram MC, Blum M, Brockmann C, Dithmar S, Friedrichs W, Guthoff R, Hattenbach LO, Herrlinger KR, Kaskel-Paul S, Khoramnia R, Klaas JE, Krohne TU, Lommatzsch A, Lueken S, Maier M, Nassri L, Nguyen-Dang TA, Radeck V, Rau S, Roider J, Sandner D, Schmalenberger L, Schmidtmann I, Schubert F, Siegel H, Spitzer MS, Stahl A, Stingl JV, Treumer F, Viestenz A, Wachtlin J, Wolf A, Zimmermann J, Schargus M, Schuster AK. Retinal Vascular Occlusion after COVID-19 Vaccination: More Coincidence than Causal Relationship? Data from a Retrospective Multicentre Study. J Clin Med 2022;11(17):5101 DOI: 10.3390/jcm11175101 Kneidinger N, Hecker M, Bessa V, Hettich I, Wald A, Wege S, Nolde AB, Oldigs M, Syunyaeva Z, Wilkens H, Gottlieb J. Outcome of lung transplant recipients infected with SARS-CoV-2/Omicron/B.1.1.529: a Nationwide German study. Infection 2022 DOI: 10.1007/s15010-022-01914-8 Pletz MW, Jensen AV, Bahrs C, Davenport C, Rupp J, Witzenrath M, Barten-Neiner G, Kolditz M, Dettmer S, Chalmers JD, Stolz D, Suttorp N, Aliberti S, Kuebler WM, Rohde G. Unmet needs in pneumonia research: a comprehensive approach by the CAPNETZ study group. Respir Res 2022;23(1):239 DOI: 10.1186/s12931-022-02117-3 Zambaiti E, Cascio S, Pelizzo G, Siles Hinojosa A, de Augustin Asensio, Juan Carlos, Fortmann C, Lacher M, Malowiecka M, Czauderna P, Arneitz C, Till H, Glenisson M, Bonnard A, Hoel AT, Bjørnland K, Hukkinen M, Demetrios G, Zavras N, Reusens H, Steyaert H, Pevere A, Aubert O, Pio L. Impact of COVID-19 pandemic on paediatric surgical training across Europe. Br J Surg 2022 DOI: 10.1093/bjs/znac306 Busch M, Hoeper MM, von Kaisenberg C, Stueber T, Stahl K. Covid-19 associated ARDS in pregnant women and timing of delivery: a single center experience. Crit Care 2022;26(1):275 DOI: 10.1186/s13054-022-04145-3 Madurka I, Vishnevsky A, Soriano JB, Gans SJ, Ore DJS, Rendon A, Ulrik CS, Bhatnagar S, Krishnamurthy S, Mc Harry K, Welte T, Fernandez AA, Mehes B, Meiser K, Gatlik E, Sommer U, Junge G, Rezende E, Fernandez AA, Bagu AM, Amido FH, Costa MB, Brigante JA, Franco G, Ahmed NJ, Zerega N, Bacci MR, Fernandes CC, Ragognete HG, de Carvalho Rezende, Ederlon Alves, Jaoude CVG, de Olivera EP, Malacize VQ, Stadnik CMB, Ramos EA, Kist GR, Barbosa GR, Filik H, Nalin S, Ulrik CS, Tidemandsen C, Hakansson K, Benfield T, Pedersen KBH, Welte T, Bachman M, Stoll M, Olzik I, Scharf N, Shearman N, Pink I, Frey A, Schulze P, Sayehli CM, Weismann D, Klinker H, Goebeler M, Maier L, Geismann F, Hanses F, Zeller J, Hupf J, Lubnow M, Sag S, Ripfel S, Pabel S, Bauernfeind S, Leisner U, Hitzenbichler F, Madurka I, Iharos D, Toth KK, Hejja M, Esze T, Bhatnagar S, Mohan A, Pandit A, Kumar B, Ratre BK, Tiwari P, Singh R, Vig S, Bhopale S, Bhan S, Budhraja A, Agrawal A, Krishnamurthy S, Srikanth A, Kaneesan K, Unnithan MRJ, Srinivasan N, Velayuthaswamy N, Gounder SKM, Vaidyanathan V, Saha A, Bhattacharjee A, Datta A, Rendon A, Ortiz AC, Moncivais BS, Rodriguez BNL, Ramirez EJR, Perez ROF, Perez DLC, Osornio JS, Ortega MLM, Medina MAJ, Gans SJ, VanDen Berg JW, Boom L, Panhuis E, Lancee G, Lammens M, Boeve-Epping N, Ore DJS, Bustios ERM, Flores EMZ, Farronay MIM, Orihuela BG, del Pino RM, Vishnevsky AY, Morozov E, Repnikov I, Kiseleva M, Kotov ME, Terskikh MM, Zykov VA, Smolyarchuk EA, Kurguzova D, Garkavi DA, Messnikov O, Kharlamova S, Bondareva YA, Sementsov KV, Katagarov DN, Belekhov GA, Alferov SP, Martynenko TI, Vasileva E, Lazarenko IV, Gatalsky KK, Rudikh OV, Ganova OS, Paraeva OS, Pashkevich VV, Vishneva EM, Martynov AV, Isakova AP, Egorova EA, Gaygolnik TV, Pinzhina VN, Hinovker VV, Abramov VG, Ignatova GL, Blinova EV, Grebneva IV, Rodionova OV, Antonov VN, Trufanov KV, Krylov AA, Radchenko EN, McHarry K, Snyman E, Soriano J, Serrano DR, Vergara AM, Marcos MC, Viladomiu AS, Cardozo C, Garcia F, group S. DFV890: a new oral NLRP3 inhibitor—tested in an early phase 2a randomised clinical trial in patients with COVID-19 pneumonia and impaired respiratory function. Infection 2022 DOI: 10.1007/s15010-022-01904-w Hochheim M, Ramm P, Wunderlich M, Amelung V. Association between chronic low back pain and regular exercise, sedentary behaviour and mental health before and during COVID-19 pandemic: insights from a large-scale cross-sectional study in Germany. BMC Musculoskelet Disord 2022;23(1):860 DOI: 10.1186/s12891-022-05806-8 Mikuteit M, Heinemann S, Roder S, Niewolik J, Schroder D, Vahldiek K, Klawitter S, Cossmann A, Bergemann T, Degen C, Klawonn F, Behrens GMN, Muller F, Dopfer-Jablonka A, Steffens S. Long term consequences of COVID-19 and the pandemic (The DEFEnse Against COVID-19 (DEFEAT CORONA) Study protocol): an online-based longitudinal observational study. JMIR Res Protoc 2022 DOI: 10.2196/38718 Jung S, Kruger THC. How the COVID-19 pandemic divides society: Towards a better understanding of differences between supporters and opponents of the COVID-19 pandemic lockdown in Germany. J Psychiatr Res 2022;155:232-240 DOI: 10.1016/j.jpsychires.2022.09.001 Arora P, Nehlmeier I, Kempf A, Cossmann A, Schulz SR, Dopfer-Jablonka A, Baier E, Tampe B, Moerer O, Dickel S, Winkler MS, Jack HM, Behrens GMN, Pohlmann S, Hoffmann M. Lung cell entry, cell-cell fusion capacity, and neutralisation sensitivity of omicron sublineage BA.2.75. Lancet Infect Dis 2022 DOI: 10.1016/S1473-3099(22)00591-6 Obed D, Salim M, Ammo T, Gildt MM, Krezdorn N, Vogt PM, Dastagir K. The effect of the COVID-19 pandemic lockdown measures on plastic, reconstructive and hand surgery emergency presentations - A comparative retrospective study in a regional referral center in Germany. Ann Med Surg (Lond) 2022:104650 DOI: 10.1016/j.amsu.2022.104650 Heiss R, Tan L, Schmidt S, Regensburger AP, Ewert F, Mammadova D, Buehler A, Vogel-Claussen J, Voskrebenzev A, Rauh M, Rompel O, Nagel AM, Levy S, Bickelhaupt S, May MS, Uder M, Metzler M, Trollmann R, Woelfle J, Wagner AL, Knieling F. Pulmonary Dysfunction after Pediatric COVID-19. Radiology 2022:221250 DOI: 10.1148/radiol.221250 Obert AJ, Kern AL, Gutberlet M, Voskrebenzev A, Kaireit TF, Crisosto C, Greer M, Krause ET, Wacker F, Vogel-Claussen J. Volume-Controlled (19) F MR Ventilation Imaging of Fluorinated Gas. J Magn Reson Imaging 2022 DOI: 10.1002/jmri.28385 Brlic PK, Pavletic M, Lerga M, Krstanovic F, Matesic MP, Miklic K, Malic S, Miksa L, Pajcur M, Peruc D, Schubert M, Bertoglio F, Arapovic J, Protic A, Sustic A, Milosevic M, Sain LC, Jonjic S, Lisnic VJ, Brizic I. SARS-CoV-2 Spike and Nucleocapsid Antibody Response in Vaccinated Croatian Healthcare Workers and Infected Hospitalized Patients: A Single Center Cohort Study. Viruses 2022;14(9):1966 DOI: 10.3390/v14091966 Sorg AL, Becht S, Jank M, Armann J, von Both U, Hufnagel M, Lander F, Liese JG, Niehues T, Verjans E, Wetzke M, Stojanov S, Behrends U, Drosten C, Schroten H, von Kries R. Association of SARS-CoV-2 Seropositivity With Myalgic Encephalomyelitis and/or Chronic Fatigue Syndrome Among Children and Adolescents in Germany. JAMA Netw Open 2022;5(9):e2233454 DOI: 10.1001/jamanetworkopen.2022.33454 Heck J, Rath AK, Wons K, Schumacher C, Kutschenko A, Noltemeyer N, Ulaganathan S, Vossiek LJ, Hijma H, van Smeden J, Schroder C, Stichtenoth DO, Wedemeyer H, Schindler C, Bosch JJ. Students' guide to documentation in clinical trials. Eur J Clin Pharmacol 2022;78(11):1861-1862 DOI: 10.1007/s00228-022-03394-z Gillmann HJ, Jung C, Speth M, Vogel-Claussen J, Stueber T. Association of radiological lung pattern and respiratory mechanics with potential for lung recruitment in patients with COVID-ARDS: a retrospective cohort study. Eur J Med Res 2022;27(1):193 DOI: 10.1186/s40001-022-00821-w Odak I, Förster R, Bošnjak B. Hide and seek with SARS-CoV-2: spike receptor-binding domain-specific memory B cells still recognize Omicron variant. Signal Transduct Target Ther 2022;7(1):343 DOI: 10.1038/s41392-022-01192-8 Weil T, Kirupakaran A, Le M, Rebmann P, Mieres-Perez J, Issmail L, Conzelmann C, Müller JA, Rauch L, Gilg A, Wettstein L, Groß R, Read C, Bergner T, Pålsson SA, Uhlig N, Eberlein V, Wöll H, Klärner F, Stenger S, Kümmerer BM, Streeck H, Fois G, Frick M, Braubach P, Spetz A, Grunwald T, Shorter J, Sanchez-Garcia E, Schrader T, Münch J. Advanced Molecular Tweezers with Lipid Anchors against SARS-CoV-2 and Other Respiratory Viruses. JACS Au 2022;2(9):2187-2202 DOI: 10.1021/jacsau.2c00220 Lugo-Agudelo LH, Spir Brunal MA, Posada Borrero AM, Cruz Sarmiento KM, Velasquez Correa JC, Di Dio Castagna Iannini, Rosarita, Gonzalez Zuluaga M, Ospina VA, Patiño Lugo DF, Mesa Franco LF, Gutenbrunner C. Countries Response for People With Disabilities During the COVID-19 Pandemic. Front Rehabil Sci 2021;2:796074 DOI: 10.3389/fresc.2021.796074 Wedemeyer H, Tergast TL, Lazarus JV, Razavi H, Bakoyannis K, Baptista-Leite R, Bartoli M, Bruggmann P, Busoi CS, Buti M, Carballo M, Castera L, Colombo M, Coutinho RS, Dadon Y, Esmat G, Esteban R, Colom Farran J, Gillyon-Powell M, Goldberg D, Hutchinson S, Janssen HLA, Kalamitsis G, Kondili LA, Lambert JS, Marinho RT, Maticic M, Patricello A, Peck-Radosavljevic M, Pol S, Poljak M, Pop C, Sokol T, Sypsa V, Tozun N, Younossi Z, Aghemo A, Papatheodoridis GV, Hatzakis A. Securing Wider EU Commitment to the Elimination of HCV. Liver Int 2022 DOI: 10.1111/liv.15446 Ackermann M, Kamp JC, Werlein C, Walsh CL, Stark H, Prade V, Surabattula R, Wagner WL, Disney C, Bodey AJ, Illig T, Leeming DJ, Karsdal MA, Tzankov A, Boor P, Kuhnel MP, Langer FP, Verleden SE, Kvasnicka HM, Kreipe HH, Haverich A, Black SM, Walch A, Tafforeau P, Lee PD, Hoeper MM, Welte T, Seeliger B, David S, Schuppan D, Mentzer SJ, Jonigk DD. The fatal trajectory of pulmonary COVID-19 is driven by lobular ischemia and fibrotic remodelling. EBioMedicine 2022;85:104296 DOI: 10.1016/j.ebiom.2022.104296 Kiyan Y, Schultalbers A, Chernobrivaia E, Tkachuk S, Rong S, Shushakova N, Haller H. Calcium dobesilate reduces SARS-CoV-2 entry into endothelial cells by inhibiting virus binding to heparan sulfate. Sci Rep 2022;12(1):16878 DOI: 10.1038/s41598-022-20973-3 Rakshit S, Adiga V, Ahmed A, Parthiban C, Chetan Kumar N, Dwarkanath P, Shivalingaiah S, Rao S, D'Souza G, Dias M, Maguire TJA, Doores KJ, Zoodsma M, Geckin B, Dasgupta P, Babji S, van Meijgaarden KE, Joosten SA, Ottenhoff THM, Li Y, Netea MG, Stuart KD, De Rosa SC, McElrath MJ, Vyakarnam A. Evidence for the heterologous benefits of prior BCG vaccination on COVISHIELD vaccine-induced immune responses in SARS-CoV-2 seronegative young Indian adults. Front Immunol 2022;13:985938 DOI: 10.3389/fimmu.2022.985938 Becker M, Cossmann A, Lurken K, Junker D, Gruber J, Juengling J, Ramos GM, Beigel A, Wrenger E, Lonnemann G, Stankov MV, Dopfer-Jablonka A, Kaiser PD, Traenkle B, Rothbauer U, Krause G, Schneiderhan-Marra N, Strengert M, Dulovic A, Behrens GMN. Longitudinal cellular and humoral immune responses after triple BNT162b2 and fourth full-dose mRNA-1273 vaccination in haemodialysis patients. Front Immunol 2022;13:1004045 DOI: 10.3389/fimmu.2022.1004045 Jonczyk R, Stanislawski N, Seiler LK, Ahani S, Bueltemeier A, Stahl F, Beutel S, Blume H, Hauss C, Melk A, Paulsen M, Stiesch M, Winkel A, Pott PC, Saletti G, Gonzalez-Hernandez M, Kaiser FK, Rimmelzwaan GF, Osterhaus ADME, Blume C. Comparison of two antibody screening systems for SARS-CoV-2 antibody detection in recovered and vaccinated subjects - test performance and possible indicators for immunity. J Clin Virol 2022;157:105322 DOI: 10.1016/j.jcv.2022.105322 Dats LB, von Haugwitz F, Seifert R. Bibliometric development of Naunyn-Schmiedeberg's Archives of Pharmacology. Naunyn Schmiedebergs Arch Pharmacol 2022 DOI: 10.1007/s00210-022-02307-2 Klimes F, Voskrebenzev A, Gutberlet M, Grimm R, Wacker F, Vogel-Claussen J. Evaluation of image registration algorithms for 3D phase-resolved functional lung (PREFUL) ventilation MR imaging in healthy volunteers and COPD patients. NMR Biomed 2022:e4860 DOI: 10.1002/nbm.4860 Haier J, Beller J, Adorjan K, Bleich S, de Greck M, Griesinger F, Heppt M, Hurlemann R, Mees ST, Philipsen A, Rohde G, Schilling G, Trautmann K, Combs SE, Geyer S, Schaefers J. Decision Conflicts in Clinical Care during COVID-19: A Multi-Perspective Inquiry. Healthcare (Basel) 2022;10(10):1914 DOI: 10.3390/healthcare10101914 Akil A, Napp LC, Rao C, Klaus T, Scheier J, Pappalardo F. Use of CytoSorb(c) Hemoadsorption in Patients on Veno-Venous ECMO Support for Severe Acute Respiratory Distress Syndrome: A Systematic Review. J Clin Med 2022;11(20):5990 DOI: 10.3390/jcm11205990 Kirchner T, Heinrich S, Bonifacius A, Engel B, Ruhl L, Pink I, Thomas N, Martens J, Hoeper MM, Blasczyk R, Wedemeyer H, Jaeckel E, Li Y, Falk CS, Eiz-Vesper B, Taubert R. Reduced humoral but stable cellular SARS-CoV-2-specific immunity in liver transplant recipients in the first year after COVID-19. PLoS One 2022;17(11):e0276929 DOI: 10.1371/journal.pone.0276929 Korper S, Gruner B, Zickler D, Wiesmann T, Wuchter P, Blasczyk R, Zacharowski K, Spieth P, Tonn T, Rosenberger P, Paul G, Pilch J, Schwable J, Bakchoul T, Thiele T, Knoerlein J, Dollinger MM, Krebs J, Bentz M, Corman VM, Kilalic D, Schmidtke-Schrezenmeier G, Lepper PM, Ernst L, Wulf H, Ulrich A, Weiss M, Kruse J, Burkhardt T, Muller R, Kluter H, Schmidt M, Jahrsdorfer B, Lotfi R, Rojewski M, Appl T, Mayer B, Schnecko P, Seifried E, Schrezenmeier H. One-year follow-up of the CAPSID randomized trial for high-dose convalescent plasma in severe COVID-19 patients. J Clin Invest 2022 DOI: 10.1172/JCI163657 Arora P, Zhang L, Nehlmeier I, Kempf A, Cossmann A, Dopfer-Jablonka A, Schulz SR, Jack HM, Behrens GMN, Pohlmann S, Hoffmann M. The effect of cilgavimab and neutralisation by vaccine-induced antibodies in emerging SARS-CoV-2 BA.4 and BA.5 sublineages. Lancet Infect Dis 2022;22(12):1665-1666 DOI: 10.1016/S1473-3099(22)00693-4 Seliger B, Jasinski-Bergner S, Massa C, Mueller A, Biehl K, Yang B, Bachmann M, Jonigk D, Eichhorn P, Hartmann A, Wickenhauser C, Bauer M. Induction of pulmonary HLA-G expression by SARS-CoV-2 infection. Cell Mol Life Sci 2022;79(11):582 DOI: 10.1007/s00018-022-04592-9 Sake SM, Kosch C, Blockus S, Haid S, Gunesch AP, Zhang X, Friesland M, Trummer SB, Grethe C, Kuhnel A, Ruckert J, Duprex WP, Huang J, Rameix-Welti M, Empting M, Fischer N, Hirsch AKH, Schulz TF, Pietschmann T. Respiratory Syncytial Virus Two-Step Infection Screen Reveals Inhibitors of Early and Late Life Cycle Stages. Antimicrob Agents Chemother 2022:e0103222 DOI: 10.1128/aac.01032-22 Blossey AM, Brückner S, May M, Parzmair GP, Sharma H, Shaligram U, Grode L, Kaufmann SHE, Netea MG, Schindler C. VPM1002 as Prophylaxis Against Severe Respiratory Tract Infections Including COVID-19 in the Elderly: a phase III randomised, double-blind, placebo-controlled, multicenter clinical study. Clin Infect Dis 2022 DOI: 10.1093/cid/ciac881 Sidarovich A, Krüger N, Rocha C, Graichen L, Kempf A, Nehlmeier I, Lier M, Cossmann A, Stankov MV, Schulz SR, Behrens GMN, Jäck H, Pöhlmann S, Hoffmann M. Host Cell Entry and Neutralization Sensitivity of SARS-CoV-2 Lineages B.1.620 and R.1. Viruses 2022;14(11):2475 DOI: 10.3390/v14112475 Tacke F, Cornberg M, Sterneck M, Trebicka J, Settmacher U, Bechstein WO, Berg T. S1-Leitlinie zur Versorgung von Lebertransplantierten während der COVID-19-Pandemie – AWMF-Registernummer: 021-031 – Stand 15. Juni 2022. Z Gastroenterol 2022;60(11):1678-1698 DOI: 10.1055/a-1934-1989 Ten Hagen NA, Twele F, Meller S, Wijnen L, Schulz C, Schoneberg C, Kreienbrock L. Canine real-time detection of SARS-CoV-2 infections in the context of a mass screening event. BMJ Glob Health 2022;7(11):e010276 DOI: 10.1136/bmjgh-2022-010276 Werlein C, Ackermann M, Stark H, Shah HR, Tzankov A, Haslbauer JD, von Stillfried S, Bülow RD, El-Armouche A, Kuenzel S, Robertus JL, Reichardt M, Haverich A, Höfer A, Neubert L, Plucinski E, Braubach P, Verleden S, Salditt T, Marx N, Welte T, Bauersachs J, Kreipe H, Mentzer SJ, Boor P, Black SM, Länger F, Kuehnel M, Jonigk D. Inflammation and vascular remodeling in COVID-19 hearts. Angiogenesis 2022 DOI: 10.1007/s10456-022-09860-7 von Sengbusch S, Schneidewind J, Bokelmann J, Scheffler N, Bertram B, Frielitz F, Hiort O, Lange K. Monthly video consultation for children and adolescents with type 1 diabetes mellitus during the COVID-19 pandemic. Diabetes Res Clin Pract 2022;193:110135 DOI: 10.1016/j.diabres.2022.110135 Niemeyer D, Stenzel S, Veith T, Schroeder S, Friedmann K, Weege F, Trimpert J, Heinze J, Richter A, Jansen J, Emanuel J, Kazmierski J, Pott F, Jeworowski LM, Olmer R, Jaboreck M, Tenner B, Papies J, Walper F, Schmidt ML, Heinemann N, Moncke-Buchner E, Baumgardt M, Hoffmann K, Widera M, Thao TTN, Balazs A, Schulze J, Mache C, Jones TC, Morkel M, Ciesek S, Hanitsch LG, Mall MA, Hocke AC, Thiel V, Osterrieder K, Wolff T, Martin U, Corman VM, Muller MA, Goffinet C, Drosten C. SARS-CoV-2 variant Alpha has a spike-dependent replication advantage over the ancestral B.1 strain in human cells with low ACE2 expression. PLoS Biol 2022;20(11):e3001871 DOI: 10.1371/journal.pbio.3001871 Hage A, de Vries M, Leffler A, Stoetzer C. Local Anesthetic Like Inhibition of the Cardiac Na(+) Channel Nav1.5 by Chloroquine and Hydroxychloroquine. J Exp Pharmacol 2022;14:353-365 DOI: 10.2147/JEP.S375349 Becker S, Jonigk D, Luft A, Dubbel L, Werlein C, Malik E, Schild-Suhren M. COVID-19 can lead to rapid progression of cervical intraepithelial neoplasia by dysregulating the immune system: A hypothesis. J Reprod Immunol 2022;154:103763 DOI: 10.1016/j.jri.2022.103763 Jacobsen H, Strengert M, Maass H, Ynga Durand MA, Katzmarzyk M, Kessel B, Harries M, Rand U, Abassi L, Kim Y, Luddecke T, Metzdorf K, Hernandez P, Ortmann J, Heise J, Castell S, Gornyk D, Glockner S, Melhorn V, Kemmling Y, Lange B, Dulovic A, Marsall P, Haring J, Junker D, Schneiderhan-Marra N, Hoffmann M, Pohlmann S, Krause G, Cicin-Sain L. Diminished neutralization responses towards SARS-CoV-2 Omicron VoC after mRNA or vector-based COVID-19 vaccinations. Sci Rep 2022;12(1):19858 DOI: 10.1038/s41598-022-22552-y Bachmann E, Zellmer S, Kahn M, Muzalyova A, Ebigbo A, Al-Nawas B, Ziebart T, Meisgeier A, Traidl-Hoffmann C, Eckstein F, Messmann H, Schlittenbauer T, Rommele C. One year of COVID-19 pandemic: Health care workers' infection rates and economical burden in medical facilities for oral and maxillofacial surgery. J Craniomaxillofac Surg 2022 DOI: 10.1016/j.jcms.2022.10.001 Zoodsma M, de Nooijer AH, Grondman I, Gupta MK, Bonifacius A, Koeken, Valerie A C M, Kooistra E, Kilic G, Bulut O, Godecke N, Janssen N, Kox M, Dominguez-Andres J, van Gammeren AJ, Ermens AAM, van der Ven, Andre J A M, Pickkers P, Blasczyk R, Behrens GMN, van de Veerdonk, Frank L, Joosten LAB, Xu C, Eiz-Vesper B, Netea MG, Li Y. Targeted proteomics identifies circulating biomarkers associated with active COVID-19 and post-COVID-19. Front Immunol 2022;13:1027122 DOI: 10.3389/fimmu.2022.1027122 Arora P, Zhang L, Rocha C, Graichen L, Nehlmeier I, Kempf A, Cossmann A, Ramos GM, Baier E, Tampe B, Moerer O, Dickel S, Winkler MS, Behrens GMN, Pohlmann S, Hoffmann M. The SARS-CoV-2 Delta-Omicron Recombinant Lineage (XD) Exhibits Immune-Escape Properties Similar to the Omicron (BA.1) Variant. Int J Mol Sci 2022;23(22):14057 DOI: 10.3390/ijms232214057 Codoni G, Kirchner T, Engel B, Villamil AM, Efe C, Stattermayer AF, Weltzsch JP, Sebode M, Bernsmeier C, Lleo A, Gevers TJ, Kupcinskas L, Castiella A, Pinazo J, De Martin E, Bobis I, Sandahl TD, Pedica F, Invernizzi F, Del Poggio P, Bruns T, Kolev M, Semmo N, Bessone F, Giguet B, Poggi G, Ueno M, Jang H, Elpek GO, Soylu NK, Cerny A, Wedemeyer H, Vergani D, Mieli-Vergani G, Lucena MI, Andrade RJ, Zen Y, Taubert R, Terziroli Beretta-Piccoli B. Histological and serological features of acute liver injury after SARS-CoV-2 vaccination. JHEP Rep 2022;5(1):100605 DOI: 10.1016/j.jhepr.2022.100605 Pisareva E, Mihalovicova L, Pastor B, Kudriavtsev A, Mirandola A, Mazard T, Badiou S, Maus U, Ostermann L, Weinmann-Menke J, Neuberger EWI, Simon P, Thierry AR. Neutrophil extracellular traps have auto-catabolic activity and produce mononucleosome-associated circulating DNA. Genome Med 2022;14(1):135 DOI: 10.1186/s13073-022-01125-8 Bafadhel M, Faner R, Taille C, Russell REK, Welte T, Barnes PJ, Agusti A. Inhaled corticosteroids for the treatment of COVID-19. Eur Respir Rev 2022;31(166):220099 DOI: 10.1183/16000617.0099 Aramburu IV, Hoving D, Vernardis SI, Tin MCF, Ioannou M, Temkin MI, De Vasconcelos NM, Demichev V, Helbig ET, Lippert L, Stahl K, White M, Radbruch H, Ihlow J, Horst D, Chiesa ST, Deanfield JE, David S, Bode C, Kurth F, Ralser M, Papayannopoulos V. Functional proteomic profiling links deficient DNA clearance with increased mortality in individuals with severe COVID-19 pneumonia. Immunity 2022 DOI: 10.1016/j.immuni.2022.11.007 Zhang B, Zhang Z, Koeken, Valerie A C M, Kumar S, Aillaud M, Tsay H, Liu Z, Kraft ARM, Soon CF, Odak I, Bosnjak B, Vlot A, Deutsche COVID-19 OMICS Initiative (DeCOI), Swertz MA, Ohler U, Geffers R, Illig T, Huehn J, Saliba A, Sander LE, Forster R, Xu C, Cornberg M, Schulte LN, Li Y. Altered and allele-specific open chromatin landscape reveals epigenetic and genetic regulators of innate immunity in COVID-19. Cell Genom 2022:100232 DOI: 10.1016/j.xgen.2022.100232 Hoffmann M, Behrens GMN, Arora P, Kempf A, Nehlmeier I, Cossmann A, Manthey L, Dopfer-Jablonka A, Pöhlmann S. Effect of hybrid immunity and bivalent booster vaccination on omicron sublineage neutralisation. Lancet Infect Dis 2022;23(1):25-28 DOI: 10.1016/S1473-3099(22)00792-7 Altawil H, Klawunn R, Dierks ML, Lander J. Parental COVID-19-related health information practises, sources, evaluations and needs: A qualitative interview study. Health Expect 2022 DOI: 10.1111/hex.13688 Beimdiek J, Janciauskiene S, Wrenger S, Volland S, Rozy A, Fuge J, Olejnicka B, Pink I, Illig T, Popov A, Chorostowska J, Buettner FFR, Welte T. Plasma markers of COVID-19 severity: a pilot study. Respir Res 2022;23(1):343 DOI: 10.1186/s12931-022-02272-7 Heinrichs H, Mueller F, Rohfleisch L, Schulz V, Talbot SR, Kiessling F. Digitalization impacts the COVID-19 pandemic and the stringency of government measures. Sci Rep 2022;12(1):21628 DOI: 10.1038/s41598-022-24726-0 Witzenrath M, Welte T. A leap towards personalised therapy of acute lung injury. Eur Respir J 2022;60(6):2201808 DOI: 10.1183/13993003.01808 Schleidgen S, Kremling A, Mertz M, Kuehlmeyer K, Inthorn J, Haltaufderheide J. How to derive ethically appropriate recommendations for action? A methodology for applied ethics. Med Health Care Philos 2022 DOI: 10.1007/s11019-022-10133-9 Heinsohn T, Lange B, Vanella P, Rodiah I, Glockner S, Joachim A, Becker D, Brandle T, Dhein S, Ehehalt S, Fries M, Galante-Gottschalk A, Jehnichen S, Kolkmann S, Kossow A, Hellmich M, Dotsch J, Krause G. Infection and transmission risks of COVID-19 in schools and their contribution to population infections in Germany: A retrospective observational study using nationwide and regional health and education agency notification data. PLoS Med 2022;19(12):e1003913 DOI: 10.1371/journal.pmed.1003913 Neb H, Talbot SR, Ruskowski K, Brkic D, Sonntagbauer M, Adam EH, von Knethen A, Zacharowski K, Heinicke U. High Heparanase Level in Survivors of Covid-19 - Indicator of Vascular and Pulmonary Recovery? Shock 2022;58(6):514-523 DOI: 10.1097/SHK.0000000000002021 Taheriyan M, Ayyoubzadeh SM, Ebrahimi M, R Niakan Kalhori S, Abooei AH, Gholamzadeh M, Ayyoubzadeh SM. Prediction of COVID-19 Patients' Survival by Deep Learning Approaches. Med J Islam Repub Iran 2022;36:144 DOI: 10.47176/mjiri.36.144 Leiskau C, Tsaka S, Meyer-Ruhnke L, Mutschler FE, Pfister E, Lainka E, Baumann U. Acute severe non-A-E-hepatitis of unknown origin in children - a 30-year retrospective observational study from north-west Germany. J Hepatol 2022 DOI: 10.1016/j.jhep.2022.12.012 Moennig E, Traidl S. Real-World Experience with Tralokinumab in a Patient with Recalcitrant Atopic Dermatitis: A Case Report. Clin Cosmet Investig Dermatol 2022;15:2825-2830 DOI: 10.2147/CCID.S382424 Lio CT, Grabert G, Louadi Z, Fenn A, Baumbach J, Kacprowski T, List M, Tsoy O. Systematic analysis of alternative splicing in time course data using Spycone. Bioinformatics 2023;39(1):btac846 DOI: 10.1093/bioinformatics/btac846 Solmi M, Thompson T, Estradé A, Agorastos A, Radua J, Cortese S, Dragioti E, Leisch F, Vancampfort D, Thygesen LC, Aschauer H, Schloegelhofer M, Aschauer E, Schneeberger A, Huber CG, Hasler G, Conus P, Do Cuénod KQ, von Känel R, Arrondo G, Fusar-Poli P, Gorwood P, Llorca PM, Krebs MO, Scanferla E, Kishimoto T, Rabbani G, Skonieczna-Żydecka K, Brambilla P, Favaro A, Takamiya A, Zoccante L, Colizzi M, Bourgin J, Kamiński K, Moghadasin M, Seedat S, Matthews E, Wells J, Vassilopoulou E, Gadelha A, Su KP, Kwon JS, Kim M, Lee TY, Papsuev O, Manková D, Boscutti A, Gerunda C, Saccon D, Righi E, Monaco F, Croatto G, Cereda G, Demurtas J, Brondino N, Veronese N, Enrico P, Politi P, Ciappolino V, Pfennig A, Bechdolf A, Meyer-Lindenberg A, Kahl KG, Domschke K, Bauer M, Koutsouleris N, Winter S, Borgwardt S, Bitter I, Balazs J, Czobor P, Unoka Z, Mavridis D, Tsamakis K, Bozikas VP, Tunvirachaisakul C, Maes M, Rungnirundorn T, Supasitthumrong T, Haque A, Brunoni AR, Costardi CG, Schuch FB, Polanczyk G, Luiz JM, Fonseca L, Aparicio LV, Valvassori SS, Nordentoft M, Vendsborg P, Hoffmann SH, Sehli J, Sartorius N, Heuss S, Guinart D, Hamilton J, Kane J, Rubio J, Sand M, Koyanagi A, Solanes A, Andreu-Bernabeu A, Cáceres ASJ, Arango C, Díaz-Caneja CM, Hidalgo-Mazzei D, Vieta E, Gonzalez-Peñas J, Fortea L, Parellada M, Fullana MA, Verdolini N, Andrlíková E, Janků K, Millan MJ, Honciuc M, Moniuszko-Malinowska A, Łoniewski I, Samochowiec J, Kiszkiel Ł, Marlicz M, Sowa P, Marlicz W, Spies G, Stubbs B, Firth J, Sullivan S, Darcin AE, Aksu H, Dilbaz N, Noyan O, Kitazawa M, Kurokawa S, Tazawa Y, Anselmi A, Cracco C, Machado AI, Estrade N, De Leo D, Curtis J, Berk M, Ward P, Teasdale S, Rosenbaum S, Marx W, Horodnic AV, Oprea L, Alexinschi O, Ifteni P, Turliuc S, Ciuhodaru T, Bolos A, Matei V, Nieman DH, Sommer I, van Os J, van Amelsvoort T, Sun CF, Guu TW, Jiao C, Zhang J, Fan J, Zou L, Yu X, Chi X, de Timary P, van Winkel R, Ng B, Pena E, Arellano R, Roman R, Sanchez T, Movina L, Morgado P, Brissos S, Aizberg O, Mosina A, Krinitski D, Mugisha J, Sadeghi-Bahmani D, Sheybani F, Sadeghi M, Hadi S, Brand S, Errazuriz A, Crossley N, Ristic DI, López-Jaramillo C, Efthymiou D, Kuttichira P, Kallivayalil RA, Javed A, Afridi MI, James B, Seb-Akahomen OJ, Fiedorowicz J, Carvalho AF, Daskalakis J, Yatham LN, Yang L, Okasha T, Dahdouh A, Gerdle B, Tiihonen J, Shin JI, Lee J, Mhalla A, Gaha L, Brahim T, Altynbekov K, Negay N, Nurmagambetova S, Jamei YA, Weiser M, Correll CU. Validation of the collaborative outcomes study on health and functioning during infection times (COH-FIT) questionnaire for adults. J Affect Disord 2022 DOI: 10.1016/j.jad.2022.12.022 Heesen G, Heinemann S, Muller F, Dopfer-Jablonka A, Mikuteit M, Niewolik J, Klawonn F, Vahldiek K, Hummers E, Schroder D. Social participation and mental health of immunocompromised individuals before and after COVID-19 vaccination-Results of a longitudinal observational study over three time points. Front Psychiatry 2022;13:1080106 DOI: 10.3389/fpsyt.2022.1080106 Rodiah I, Vanella P, Kuhlmann A, Jaeger VK, Harries M, Krause G, Karch A, Bock W, Lange B. Age-specific contribution of contacts to transmission of SARS-CoV-2 in Germany. Eur J Epidemiol 2023 DOI: 10.1007/s10654-022-00938-6 Jansen-Olliges L, Chatterjee S, Jia L, Stahl F, Bar C, Stadler M, Surup F, Zeilinger C. Multiformin-Type Azaphilones Prevent SARS-CoV-2 Binding to ACE2 Receptor. Cells 2022;12(1):83 DOI: 10.3390/cells12010083 Arora P, Cossmann A, Schulz SR, Ramos GM, Stankov MV, Jack H, Behrens GMN, Pohlmann S, Hoffmann M. Neutralisation sensitivity of the SARS-CoV-2 XBB.1 lineage. Lancet Infect Dis 2023 DOI: 10.1016/S1473-3099(22)00831-3 Dorn F, Lange B, Braml M, Gstrein D, Nyirenda JLZ, Vanella P, Winter J, Fuest C, Krause G. The challenge of estimating the direct and indirect effects of COVID-19 interventions - Toward an integrated economic and epidemiological approach. Econ Hum Biol 2022;49:101198 DOI: 10.1016/j.ehb.2022.101198 Ackermann M, Tafforeau P, Brunet J, Kamp JC, Werlein C, Kuhnel MP, Jacob J, Walsh CL, Lee PD, Welte T, Jonigk DD. Reply to: Intrapulmonary Shunt and Alveolar Dead Space in a Cohort of Patients with Acute COVID-19 Pneumonitis and Early Recovery. Eur Respir J 2023 DOI: 10.1183/13993003.02121-2022 Bojkova D, Reus P, Panosch L, Bechtel M, Rothenburger T, Kandler JD, Pfeiffer A, Wagner JUG, Shumliakivska M, Dimmeler S, Olmer R, Martin U, Vondran FWR, Toptan T, Rothweiler F, Zehner R, Rabenau HF, Osman KL, Pullan ST, Carroll MW, Stack R, Ciesek S, Wass MN, Michaelis M, Cinatl JJ. Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform. iScience 2023:105944 DOI: 10.1016/j.isci.2023.105944 Niewolik J, Mikuteit M, Schroder D, Heinemann S, Heesen G, Muller F, Dopfer-Jablonka A, Grimmelmann I, Steffens S. Soziale Teilhabe und Hautkrebs während der COVID-19-Pandemie. Dermatologie (Heidelb) 2023;74(2):108-113 DOI: 10.1007/s00105-022-05093-3 Original-/übers. Titel: Social participation and melanoma during the COVID-19 pandemic Giesen N, Busch E, Schalk E, Beutel G, Ruthrich MM, Hentrich M, Hertenstein B, Hirsch HH, Karthaus M, Khodamoradi Y, Koehler P, Kruger W, Koldehoff M, Krause R, Mellinghoff SC, Penack O, Sandherr M, Seggewiss-Bernhardt R, Spiekermann K, Sprute R, Stemler J, Weissinger F, Wormann B, Wolf H, Cornely OA, Rieger CT, von Lilienfeld-Toal M. AGIHO guideline on evidence-based management of COVID-19 in cancer patients: 2022 update on vaccination, pharmacological prophylaxis and therapy in light of the omicron variants. Eur J Cancer 2022;181:102-118 DOI: 10.1016/j.ejca.2022.11.030 Sahajpal NS, Hastie AR, Schieck M, Mondal AK, Felde M, van der Made CI, Chou JS, Randolph AG, Illig T, Zody MC, Brownstein CA, Beggs AH, Hoischen A, Chaubey A, Kolhe R, COVID19hostgenomesv Consortium. Genetic Predisposition to Neurological Complications in Patients with COVID-19. Biomolecules 2023;13(1):133 DOI: 10.3390/biom13010133 Hümmert MW, Bütow F, Tkachenko D, Ayzenberg I, Pakeerathan T, Hellwig K, Klotz L, Häussler V, Stellmann J, Warnke C, Goereci Y, Etgen T, Luessi F, Bronzlik P, Gingele S, Lauenstein A, Kleiter I, Rommer PS, Paul F, Bellmann-Strobl J, Duchow A, Then Bergh F, Pul R, Walter A, Pellkofer H, Kumpfel T, Pompsch M, Kraemer M, Albrecht P, Aktas O, Ringelstein M, Senel M, Giglhuber K, Berthele A, Jarius S, Wildemann B, Trebst C, Neuromyelitis Optica Study Group (NEMOS). Effects of the COVID-19 Pandemic on Patients With NMO Spectrum Disorders and MOG-Antibody-Associated Diseases: COPANMO(G)-Study. Neurol Neuroimmunol Neuroinflamm 2023;10(2):e200082 DOI: 10.1212/NXI.0000000000200082 Boss K, Konik M, Bräsen JH, Schmitz J, Jürgens C, Kribben A, Witzke O, Dolff S, Gäckler A. COVID-19 associated acute transplant failure after AB0-incompatible living donor kidney transplantation - a case report. BMC Nephrol 2023;24(1):19 DOI: 10.1186/s12882-023-03070-z Lucifora J, Alfaiate D, Pons C, Michelet M, Ramirez R, Fusil F, Amirache F, Rossi A, Legrand A, Charles E, Vegna S, Farhat R, Rivoire M, Passot G, Gadot N, Testoni B, Bach C, Baumert TF, Hyrina A, Beran RK, Zoulim F, Boonstra A, Buning H, Verrier ER, Cosset F, Fletcher SP, Salvetti A, Durantel D. Hepatitis D virus interferes with hepatitis B virus RNA production via interferon-dependent and -independent mechanisms. J Hepatol 2023 DOI: 10.1016/j.jhep.2023.01.005 Oppermann L, Dierks M. Promotion of physical activity-related health competence using digital workplace-based health promotion: protocol for a controlled before-and-after study. BMJ Open Sport Exerc Med 2023;9(1):e001464 DOI: 10.1136/bmjsem-2022-001464 Kamp JC, Werlein C, Plucinski EK, Neubert L, Welte T, Lee PD, Tafforeau P, Walsh C, Kuehnel MP, Schuppan D, Hoeper MM, Jonigk DD, Ackermann M. Novel Insight into Pulmonary Fibrosis and Long Covid. Am J Respir Crit Care Med 2023 DOI: 10.1164/rccm.202212-2314LE Rosain J, Neehus A, Manry J, Yang R, Le Pen J, Daher W, Liu Z, Chan Y, Tahuil N, Türel Ö, Bourgey M, Ogishi M, Doisne J, Izquierdo HM, Shirasaki T, Le Voyer T, Guérin A, Bastard P, Moncada-Vélez M, Han JE, Khan T, Rapaport F, Hong S, Cheung A, Haake K, Mindt BC, Pérez L, Philippot Q, Lee D, Zhang P, Rinchai D, Al Ali F, Ahmad Ata MM, Rahman M, Peel JN, Heissel S, Molina H, Kendir-Demirkol Y, Bailey R, Zhao S, Bohlen J, Mancini M, Seeleuthner Y, Roelens M, Lorenzo L, Soudée C, Paz MEJ, González ML, Jeljeli M, Soulier J, Romana S, L’Honneur A, Materna M, Martínez-Barricarte R, Pochon M, Oleaga-Quintas C, Michev A, Migaud M, Lévy R, Alyanakian M, Rozenberg F, Croft CA, Vogt G, Emile J, Kremer L, Ma CS, Fritz JH, Lemon SM, Spaan AN, Manel N, Abel L, MacDonald MR, Boisson-Dupuis S, Marr N, Tangye SG, Di Santo JP, Zhang Q, Zhang S, Rice CM, Béziat V, Lachmann N, Langlais D, Casanova J, Gros P, Bustamante J. Human IRF1 governs macrophagic IFN-γ immunity to mycobacteria. Cell 2023;186(3):621-645.e33 DOI: 10.1016/j.cell.2022.12.038 Schwake C, Pakeerathan T, Kleiter I, Ringelstein M, Aktas O, Korporal-Kuhnke M, Wildemann B, Jarius S, Bayas A, Pul R, Ceylan U, Faissner S, Hellwig K, Ayroza Galvao Ribeiro Gomes, Ana Beatriz, Lipps P, Probstel A, Kumpfel T, Oswald E, Then Bergh F, Godel C, Hummert MW, Trebst C, Gold R, Ayzenberg I. Humoral COVID-19 vaccine response in patients with NMOSD/MOGAD during anti-IL-6 receptor therapy compared to other immunotherapies. Mult Scler 2023:13524585221151124 DOI: 10.1177/13524585221151124 Vogel-Claussen J. Ventilation Defects at (129)Xe MRI in Post-acute COVID-19 Syndrome: Back to Normal after 1 year? Radiology 2023 DOI: 10.1148/radiol.230113 Stanislawski N, Lange F, Fahnemann C, Riggers C, Wahalla M, Porr M, Cholewa F, Jonczyk R, Thoms S, Witt M, Stahl F, Beutel S, Winkel A, Pott P, Stiesch M, Paulsen M, Melk A, Lucas H, Heiden S, Blume H, Blume C. Mobile SARS‑CoV‑2 screening facilities for rapid deployment and university-based diagnostic laboratory. Eng Life Sci 2023;23(2):2200026 DOI: 10.1002/elsc.202200026 Chochkova-Bukova LA, Funken D, Bukova M, Genova KZ, Ali S, Stoencheva S, Paskaleva IN, Halil Z, Neicheva I, Shishmanova A, Kelly KS, Ivanov IS. Cardiac MRI with late gadolinium enhancement shows cardiac involvement 3-6 months after severe acute COVID-19 similar to or worse than PIMS. Front Cardiovasc Med 2023;10:1115389 DOI: 10.3389/fcvm.2023.1115389 Bauer C, Zhang K, Li W, Bernson D, Dammann O, LaRochelle MR, Stopka TJ. Small Area Forecasting of Opioid-Related Mortality: Bayesian Spatiotemporal Dynamic Modeling Approach. JMIR Public Health Surveill 2023;9:e41450 DOI: 10.2196/41450 Nomden M, Alizai NK, Betalli P, Bruggink JLM, Cananzi M, Christensen VB, D'Antiga L, Davenport M, Fischler B, Hindemith L, Hukkinen M, Johansen LS, de Kleine RH, Madadi-Sanjani O, Ong EGP, Pakarinen MP, Petersen C, Ruiz M, Schunn M, Sturm E, Verkade HJ, Wildhaber BE, Hulscher JBF, On Behalf Of Members Of The Biliary Atresia And Related Disorders Bard Community The Ern Ra-Re-Liver. Incidence of Isolated Biliary Atresia during the COVID Lockdown in Europe: Results from a Collaborative Project by RARE-Liver. J Clin Med 2023;12(3):775 DOI: 10.3390/jcm12030775 Geckin B, Zoodsma M, Kilic G, Debisarun PA, Rakshit S, Adiga V, Ahmed A, Parthiban C, Kumar NC, D'Souza G, Baltissen MP, Martens JHA, Dominguez-Andres J, Li Y, Vyakarnam A, Netea MG. Differences in Immune Responses in Individuals of Indian and European Origin: Relevance for the COVID-19 Pandemic. Microbiol Spectr 2023:e0023123 DOI: 10.1128/spectrum.00231-23 Jank M, Oechsle A, Armann J, Behrends U, Berner R, Chao C, Diffloth N, Doenhardt M, Hansen G, Hufnagel M, Lander F, Liese JG, Muntau AC, Niehues T, von Both U, Verjans E, Weil K, von Kries R, Schroten H. Comparing SARS-CoV-2 variants among children and adolescents in Germany: relative risk of COVID-19-related hospitalization, ICU admission and mortality. Infection 2023 DOI: 10.1007/s15010-023-01996-y Li E, Tsopra R, Jimenez G, Serafini A, Gusso G, Lingner H, Fernandez MJ, Irving G, Petek D, Hoffman R, Lazic V, Memarian E, Koskela T, Collins C, Espitia SM, Claveria A, Nessler K, O'Neill BG, Hoedebecke K, Ungan M, Laranjo L, Ghafur S, Fontana G, Majeed A, Car J, Darzi A, Neves AL. General practitioners' perceptions of using virtual primary care during the COVID-19 pandemic: An international cross-sectional survey study. PLOS Digit Health 2022;1(5):e0000029 DOI: 10.1371/journal.pdig.0000029 Kuhlmann E, Lotta G, Fernandez M, Herten-Crabb A, Mac Fehr L, Maple J, Paina L, Wenham C, Willis K. SDG5 "Gender Equality" and the COVID-19 pandemic: A rapid assessment of health system responses in selected upper-middle and high-income countries. Front Public Health 2023;11:1078008 DOI: 10.3389/fpubh.2023.1078008 Gerhards SK, Luppa M, Röhr S, Pabst A, Bauer A, Frankhänel T, Döhring J, Escales C, Zöllinger IR, Oey A, Brettschneider C, Wiese B, Hoffmann W, Gensichen J, König H, Frese T, Thyrian JR, Kaduszkiewicz H, Riedel-Heller SG. Depression and Anxiety in Old Age during the COVID-19 Pandemic: A Comparative Study of Individuals at Cardiovascular Risk and the General Population. Int J Environ Res Public Health 2023;20(4):2975 DOI: 10.3390/ijerph20042975 Geiger N, Diesendorf V, Roll V, König E, Obernolte H, Sewald K, Breidenbach J, Pillaiyar T, Gutschow M, Müller CE, Bodem J. Cell Type-Specific Anti-Viral Effects of Novel SARS-CoV-2 Main Protease Inhibitors. Int J Mol Sci 2023;24(4):3972 DOI: 10.3390/ijms24043972 Metzdorf K, Jacobsen H, Greweling-Pils MC, Hoffmann M, Lüddecke T, Miller F, Melcher L, Kempf AM, Nehlmeier I, Bruder D, Widera M, Ciesek S, Pohlmann S, Cicin-Sain L. TMPRSS2 Is Essential for SARS-CoV-2 Beta and Omicron Infection. Viruses 2023;15(2):271 DOI: 10.3390/v15020271 Pabst A, Zeller AN, Raguse JD, Hoffmann J, Goetze E. Microvascular reconstructions in oral and maxillofacial surgery - Results of a survey among oral and maxillofacial surgeons in Germany, Austria, and Switzerland. J Craniomaxillofac Surg 2023 DOI: 10.1016/j.jcms.2023.02.003 Kanzelmeyer NK, Weigel F, Boeckenhauer J, Haffner D, Oh J, Schild R. Impact of the COVID-19 pandemic on body mass index in children and adolescents after kidney transplantation. Pediatr Nephrol 2023:1-8 DOI: 10.1007/s00467-023-05902-4 Schmidbauer M, Busjahn A, Paprottka P, Bücker A, Nadjiri J, Wacker FK. Auswirkung der COVID-19-Pandemie auf die Interventionelle Radiologie in Deutschland. Rofo 2023 DOI: 10.1055/a-2018-3512 Original-/übers. Titel: Impact of the COVID-19 Pandemic on Interventional Radiology in Germany Hilbold E, Bär C, Thum T. COVID-19: Insights into long-term manifestations and lockdown impacts. J Sport Health Sci 2023 DOI: 10.1016/j.jshs.2023.02.006 Hoffmann M, Arora P, Nehlmeier I, Kempf A, Cossmann A, Schulz SR, Morillas Ramos G, Manthey LA, Jäck HM, Behrens GMN, Pöhlmann S. Profound neutralization evasion and augmented host cell entry are hallmarks of the fast-spreading SARS-CoV-2 lineage XBB.1.5. Cell Mol Immunol 2023 DOI: 10.1038/s41423-023-00988-0 Lemhöfer C, Sturm C, Loudovici-Krug D, Guntenbrunner C, Bülow M, Reuken P, Quickert S, Best N. Quality of life and ability to work of patients with Post-COVID syndrome in relation to the number of existing symptoms and the duration since infection up to 12 months: a cross-sectional study. Qual Life Res 2023 DOI: 10.1007/s11136-023-03369-2 Qu Z. International cooperation to end the COVID-19 pandemic. Lancet 2023;401(10379):820 DOI: 10.1016/S0140-6736(23)00348-3 Behr J, Berger M, Blum TG, Bonella F, Dinkel J, Gläser S, Hagmeyer L, Kneidinger N, Koschel D, Prasse A, Slevogt H, Stacher-Priehse E, Woehrle H, Kreuter M. SARS-CoV-2-Infektion und interstitielle Lungenerkrankungen - Positionspapier der Deutschen Gesellschaft für Pneumologie und Beatmungsmedizin. Pneumologie 2023;77(3):143-157 DOI: 10.1055/a-2007-9845 Original-/übers. Titel: SARS-CoV-2-Infection and Interstitial Lung Disease: Position paper of the German Respiratory Society Tang X, Xue D, Zhang T, Nilsson-Payant BE, Carrau L, Duan X, Gordillo M, Tan AY, Qiu Y, Xiang J, Schwartz RE, tenOever BR, Evans T, Chen S. A multi-organoid platform identifies CIART as a key factor for SARS-CoV-2 infection. Nat Cell Biol 2023;25(3):381-389 DOI: 10.1038/s41556-023-01095-y Gottlieb J, Simon S, Barton J, Barnikel M, Bachmann M, Klingenberg M, Veit T, Kneidinger N. Efficacy of pre-exposure prophylaxis to prevent SARS-CoV-2 infection after lung transplantation: a two center cohort study during the omicron era. Infection 2023 DOI: 10.1007/s15010-023-02018-7 Bojkova D, Bechtel M, Rothenburger T, Kandler JD, Hayes L, Olmer R, Martin U, Jonigk D, Ciesek S, Wass MN, Michaelis M, Cinatl JJ. Omicron-induced interferon signalling prevents influenza A H1N1 and H5N1 virus infection. J Med Virol 2023 DOI: 10.1002/jmv.28686 Ares-Blanco S, Guisado-Clavero M, Ramos Del Rio L, Gefaell Larrondo I, Fitzgerald L, Adler L, Assenova R, Bakola M, Bayen S, Brutskaya-Stempkovskaya E, Busneag I, Domeyer P, Gjorgjievski D, Hoffmann K, capital I, Ukrainiansmall el, Cyrillicsmall soft sign, Cyrillicsmall ka, Cyrillicsmall o, Cyrillicsmall ve, Cyrillic, capital O, Cyrillicsmall ka, Cyrillicsmall es, Cyrillicsmall a, Cyrillicsmall en, Cyrillicsmall a, Cyrillic, Trifon Karathanos V, Kirkovski A, Knezevic S, Cimen Korkmaz B, Heleno B, Nessler K, Murauskiene L, Neves AL, Parodi Lopez N, Perjes A, Petek D, Petrazzuoli F, Petricek G, Seifert B, Serafini A, Sentker T, Tiili P, Torzsa P, Vaes B, van Pottebergh G, Vinker S, Astier-Pena MP, Gomez-Bravo R, Lingner H, Clinical investigatorsdagger, Clinical investigators:. Clinical pathway of COVID-19 patients in primary health care in 30 European countries: Eurodata study. Eur J Gen Pract 2023:2182879 DOI: 10.1080/13814788.2023.2182879 Mardiko AA, Bludau A, Heinemann S, Kaba HEJ, Fenz D, Leha A, von Maltzahn N, Mutters NT, Leistner R, Mattner F, Scheithauer S. Infection control strategies for healthcare workers during COVID-19 pandemic in German hospitals: A cross-sectional study in march-april 2021. Heliyon 2023;9(3):e14658 DOI: 10.1016/j.heliyon.2023.e14658 Schmachtenberg T, Müller F, Kranz J, Dragaqina A, Wegener G, Königs G, Roder S. How do long COVID patients perceive their current life situation and occupational perspective? Results of a qualitative interview study in Germany. Front Public Health 2023;11:1155193 DOI: 10.3389/fpubh.2023.1155193 Nchioua R, Schundner A, Klute S, Koepke L, Hirschenberger M, Noettger S, Fois G, Zech F, Graf A, Krebs S, Braubach P, Blum H, Stenger S, Kmiec D, Frick M, Kirchhoff F, Sparrer KM. Reduced replication but increased interferon resistance of SARS-CoV-2 Omicron BA.1. Life Sci Alliance 2023;6(6):e202201745 Kuhlmann E, Denis J, Cote N, Lotta G, Neri S. Comparing Health Workforce Policy during a Major Global Health Crisis: A Critical Conceptual Debate and International Empirical Investigation. Int J Environ Res Public Health 2023;20(6):5035 DOI: 10.3390/ijerph20065035 Papi A, Stapleton RD, Shore PM, Bica MA, Chen Y, Larbig M, Welte T. Efficacy and Safety of Garadacimab in Combination with Standard of Care Treatment in Patients with Severe COVID-19. Lung 2023;201(2):159-170 DOI: 10.1007/s00408-023-00615-9 Martin-Loeches I, Torres A, Nagavci B, Aliberti S, Antonelli M, Bassetti M, Bos L, Chalmers J, Derde L, de Waele J, Garnacho-Montero J, Kollef M, Luna C, Menendez R, Niederman M, Ponomarev D, Restrepo M, Rigau D, Schultz M, Weiss E, Welte T, Wunderink R. ERS/ESICM/ESCMID/ALAT guidelines for the management of severe community-acquired pneumonia. Eur Respir J 2023;61(4):2200735 DOI: 10.1183/13993003.00735-2022 Ware L, Soleymanlou N, McAuley DF, Estrada V, Diaz GA, Lacamera P, Kaste R, Choi W, Gupta A, Welte T. TRPC6 inhibitor (BI 764198) to reduce risk and severity of ARDS due to COVID-19: a phase II randomised controlled trial. Thorax 2023 DOI: 10.1136/thorax-2022-219668 Ruhl L, Kühne JF, Beushausen K, Keil J, Christoph S, Sauer J, Falk CS. Third SARS-CoV-2 vaccination and breakthrough infections enhance humoral and cellular immunity against variants of concern. Front Immunol 2023;14:1120010 DOI: 10.3389/fimmu.2023.1120010 Mardiko AA, Buer J, Köster AM, Kaba HEJ, Mattner F, Zweigner J, Mutters NT, von Maltzahn N, Leistner R, Eckmanns T, Brandt C, Scheithauer S. Infection Prevention and Control between Legal Requirements and "German Society for Hygiene and Microbiology" Expert Assessments: A Cross-Sectional Study in September-November 2022. J Hosp Infect 2023 DOI: 10.1016/j.jhin.2023.04.001 Pilchova V, Prajeeth CK, Jendrny P, Twele F, Meller S, Pink I, Fathi A, Addo MM, Volk H, Osterhaus A, von Köckritz-Blickwede M, Schulz C. beta-Propiolactone (BPL)-inactivation of SARS-Co-V-2: in vitro validation with focus on saliva from COVID-19 patients for scent dog training. J Virol Methods 2023:114733 DOI: 10.1016/j.jviromet.2023.114733

Cell Levels : The Randomized , Controlled IVIST Trial." J Am Soc Nephrol 32(2):502-16. doi: 10.1681/ASN.2020050645. Albrecht, Fenja, Heidi Wolters, Yvonne Ziert , Beate Timmermann, Rolf Dieter Kortmann,

Publications Supported by the Core Facility (Selection) 2026 B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression. Eckert N, Werth K, Willenzon S, Tan L, Förster R. J Leukoc Biol. 2020 Jun;107(6):1155-1166. doi: 10.1002/JLB.2MA1119-300R. Epub 2019 Dec 16. PMID: 31841228 Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality. Fleischauer J, John-Neek P, Ha TC, Mansel F, Kosanke M, Selich A, Hagedorn M, Bastone AL, Schinke M, Dziadek V, Dittrich-Breiholz O, von Kaisenberg C, Schambach A, Rothe M. J Transl Med. 2026 Feb 7;24(1):384. doi: 10.1186/s12967-026-07700-6. PMID: 41654907 Free PMC article. Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cells. Fritz L, Hassan A, Riemann L, Čuvalo B, Costa B, Wieland B, Eiz-Vesper B, Falk C, Roesner LM, Werfel T, Kalinke U, Georgiev H, Förster R, Bošnjak B. EBioMedicine. 2026 Jan;123:106107. doi: 10.1016/j.ebiom.2025.106107. Epub 2026 Jan 5. PMID: 41494240 Free PMC article. Differential mitochondrial priming by BCR::ABL1 in B-cell precursor acute lymphoblastic leukemia. Kirchhoff H, Schoenherr C, Fleischer L, Talbot SR, Heidel FH, Bergmann AK, Eder M, Scherr M. Leukemia. 2026 Mar 30. doi: 10.1038/s41375-026-02944-z. Online ahead of print. PMID: 41912910 No abstract available. Focusing of the regulatory T-cell repertoire after allogeneic stem cell transplantation indicates protection from graft- versus -host disease. Odak I, Raha S, Schultze-Florey C, Tavil S, Ravens S, Ganser A, Förster R, Prinz I, Koenecke C. Haematologica. 2019 Dec;104(12):e577-e580. doi: 10.3324/haematol.2019.218206. Epub 2019 Apr 24. PMID: 31018979 Free PMC article. No abstract available. 2025 Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity. Baatz F, Ghosh A, Herbst J, Polten S, Meyer J, Rhiel M, Maetzig T, Geffers R, Rothe M, Bastone AL, John-Neek P, Frühauf J, Eiz-Vesper B, Bonifacius A, Falk CS, Kaisenberg CV, Cathomen T, Schambach A, van den Brink MRM, Hust M, Sauer MG. Mol Ther. 2025 Apr 2;33(4):1584-1607. doi: 10.1016/j.ymthe.2025.02.024. Epub 2025 Feb 15. PMID: 39955618 Free PMC article. LMP2A-Targeting CAR-T Cells Equipped With Inducible IL-18 to Address EBV-Associated Malignancies. Dragon AC, Thoelke S, Mausberg P, Zimmermann K, Blasczyk R, Hudecek M, Abken H, Schambach A, Maecker-Kolhoff B, Eiz-Vesper B. HLA. 2025 Oct;106(4):e70439. doi: 10.1111/tan.70439. PMID: 41116979 Free PMC article. PAM-interacting domain turn-helix 51 motifs can improve Cas9-SpRY activity. Eggenschwiler R, Hoffmann T, Dmytrenko O, Opitz M, Ackel-Zakour M, Wang P, McCallan SA, Fráguas-Eggenschwiler M, Niemann H, Patronov A, Beisel CL, Cantz T. Nucleic Acids Res. 2025 Aug 11;53(15):gkaf782. doi: 10.1093/nar/gkaf782. PMID: 40808297 Free PMC article. Developmental features and unique characteristics of peptide-specific PLZF+ innate-like T cells in mice. Hassan A, Heise N, Schimrock A, Willenzon S, Ravens I, Förster R, Georgiev H. Nat Commun. 2025 Jun 6;16(1):5274. doi: 10.1038/s41467-025-60617-4. PMID: 40480992 Free PMC article. Acquisition of innate B cell properties and generation of autoreactive IgA antibodies by follicular B cells during homeostatic proliferation. Kampe L, Melcher C, Westphal K, Brand K, Föger N, Lee KH. Front Immunol. 2025 Jan 22;16:1506628. doi: 10.3389/fimmu.2025.1506628. eCollection 2025. PMID: 39911392 Free PMC article. Combination of targeted pharmacotherapy and immunotherapy with anti-CD19 CAR NK cells in acute lymphoblastic leukemia. Kirchhoff H, Schoenherr C, Fleischer L, Schweighart EK, Esser R, Talbot SR, Schambach A, Koehl U, Heidenreich O, Eder M, Scherr M. Hemasphere. 2025 Oct 15;9(10):e70238. doi: 10.1002/hem3.70238. eCollection 2025 Oct. PMID: 41104377 Free PMC article. Inflammatory modalities shape the IgA repertoire via stochastic processes. Melcher C, Schramm CA, Kampe L, Zhang Y, Westphal K, Krautkrämer M, Shen X, Brand K, Franz P, Vital M, Douek DC, Föger N, Lee KH. Cell Rep. 2025 Oct 28;44(10):116307. doi: 10.1016/j.celrep.2025.116307. Epub 2025 Sep 16. PMID: 40966088 Free article. Anti-FAP CAR-NK cells as a novel targeted therapy against cervical cancer and cancer-associated fibroblasts. Polten R, Kutle I, Stalp JL, Hachenberg J, Seyda AK, Neubert L, Kamp JC, von Kaisenberg C, Schaudien D, Hillemanns P, Klapdor R, Morgan M, Schambach A. Oncoimmunology. 2025 Dec;14(1):2556714. doi: 10.1080/2162402X.2025.2556714. Epub 2025 Sep 17. PMID: 40960024 Free PMC article. Vitamin C conditioning generates tumor-targeting CAR T cells with superior cytotoxicity and fitness in a post-transplant lymphoproliferative disorder tumor model. Rahmati P, Bonifacius A, Dragon AC, Malinconico C, Floegel F, Halenius A, Blasczyk R, Maecker-Kolhoff B, Hudecek M, Floess S, Huehn J, Eiz-Vesper B. Mol Cancer Ther. 2025 Dec 19. doi: 10.1158/1535-7163.MCT-25-0005. Online ahead of print. PMID: 41416402 Partial Compensation of IL-17 Production by Vγ1 T Cells in the Absence of Vγ4 and Vγ6 T Cells. Wang Z, Yang T, Lupo F, Behrens LM, Janssen A, Coffelt SB, Prinz I, Sandrock I, Ravens S. Eur J Immunol. 2025 Sep;55(9):e70061. doi: 10.1002/eji.70061. PMID: 40974348 Free PMC article. Systematic monocyte subset analysis reveals differential contribution of Notch signaling components to monocyte heterogeneity. Xu Y, Kapanadze T, Gaedcke S, Jirmo AC, Sablotny S, Schroth FN, Hille S, Müller OJ, Lochner M, Haller H, Schmidt-Ott K, Gamrekelashvili J, Limbourg FP. iScience. 2025 Oct 16;28(11):113795. doi: 10.1016/j.isci.2025.113795. eCollection 2025 Nov 21. PMID: 41244563 Free PMC article. 2024 Standardized generation of human iPSC-derived hematopoietic organoids and macrophages utilizing a benchtop bioreactor platform under fully defined conditions. Ackermann M, Saleh F, Abdin SM, Rafiei Hashtchin A, Gensch I, Golgath J, Carvalho Oliveira M, Nguyen AHH, Gaedcke S, Fenske A, Jang MS, Jirmo AC, Abeln M, Hansen G, Lachmann N. Stem Cell Res Ther. 2024 Jun 18;15(1):171. doi: 10.1186/s13287-024-03785-2. PMID: 38886860 Free PMC article. A tetravalent bispecific antibody outperforms the combination of its parental antibodies and neutralizes diverse SARS-CoV-2 variants. Chiyyeadu A, Asgedom G, Bruhn M, Rocha C, Schlegel TU, Neumann T, Galla M, Vollmer Barbosa P, Hoffmann M, Ehrhardt K, Ha TC, Morgan M, Schoeder CT, Pöhlmann S, Kalinke U, Schambach A. Clin Immunol. 2024 Mar;260:109902. doi: 10.1016/j.clim.2024.109902. Epub 2024 Jan 11. PMID: 38218210 Free article. Early-life thymectomy leads to an increase of granzyme-producing γδ T cells in children with congenital heart disease. Cramer A, Yang T, Riemann L, Almeida V, Kammeyer C, Abu YE, Gluschke E, Kleiner S, León-Lara X, Janssen A, Hofmann A, Horke A, von Kaisenberg C, Förster R, Beerbaum P, Boehne M, Ravens S. Nat Commun. 2024 Nov 13;15(1):9841. doi: 10.1038/s41467-024-51673-3. PMID: 39537635 Free PMC article. Blood-generating heart-forming organoids recapitulate co-development of the human haematopoietic system and the embryonic heart. Dardano M, Kleemiß F, Kosanke M, Lang D, Wilson L, Franke A, Teske J, Shivaraj A, de la Roche J, Fischer M, Lange L, Schambach A, Drakhlis L, Zweigerdt R. Nat Cell Biol. 2024 Nov;26(11):1984-1996. doi: 10.1038/s41556-024-01526-4. Epub 2024 Oct 8. Mineralocorticoid receptor promotes cardiac macrophage inflammaging. Fraccarollo D, Geffers R, Galuppo P, Bauersachs J. Basic Res Cardiol. 2024 Apr;119(2):243-260. doi: 10.1007/s00395-024-01032-6. Epub 2024 Feb 8. PMID: 38329499 Free PMC article. Validation of CSF-1 receptor (CD115) staining for analysis of murine monocytes by flow cytometry. Kapanadze T, Gamrekelashvili J, Sablotny S, Schroth FN, Xu Y, Chen R, Rong S, Shushakova N, Gueler F, Haller H, Limbourg FP. J Leukoc Biol. 2024 Feb 23;115(3):573-582. doi: 10.1093/jleuko/qiad147. PMID: 38038378 Anti-Mesothelin CAR-NK cells as a novel targeted therapy against cervical cancer. Kutle I, Polten R, Stalp JL, Hachenberg J, Todzey F, Hass R, Zimmermann K, von der Ohe J, von Kaisenberg C, Neubert L, Kamp JC, Schaudien D, Seyda AK, Hillemanns P, Klapdor R, Morgan MA, Schambach A. Front Immunol. 2024 Dec 16;15:1485461. doi: 10.3389/fimmu.2024.1485461. eCollection 2024. PMID: 39781381 Free PMC article. γδ T cell profiling in a cohort of preterm infants reveals elevated frequencies of CD83+ γδ T cells in sepsis. León-Lara X, Fichtner AS, Willers M, Yang T, Schaper K, Riemann L, Schöning J, Harms A, Almeida V, Schimrock A, Janssen A, Ospina-Quintero L, von Kaisenberg C, Förster R, Eberl M, Richter MF, Pirr S, Viemann D, Ravens S. J Exp Med. 2024 Jul 1;221(7):e20231987. doi: 10.1084/jem.20231987. Epub 2024 May 16. PMID: 38753245 Free PMC article. Epitope-focused immunogens targeting the hepatitis C virus glycoproteins induce broadly neutralizing antibodies. Nagarathinam K, Scheck A, Labuhn M, Ströh LJ, Herold E, Veselkova B, Tune S, Cramer JT, Rosset S, Vollers SS, Bankwitz D, Ballmaier M, Böning H, Roth E, Khera T, Ahsendorf-Abidi HP, Dittrich-Breiholz O, Obleser J, Nassal M, Jäck HM, Pietschmann T, Correia BE, Krey T. Sci Adv. 2024 Dec 6;10(49):eado2600. doi: 10.1126/sciadv.ado2600. Epub 2024 Dec 6. PMID: 39642219 Free PMC article. Non-esterified fatty acid palmitate facilitates oxidative endoplasmic reticulum stress and apoptosis of β-cells by upregulating ERO-1α expression. Sharifi S, Yamamoto T, Zeug A, Elsner M, Avezov E, Mehmeti I. Redox Biol. 2024 Jul;73:103170. doi: 10.1016/j.redox.2024.103170. Epub 2024 Apr 27. PMID: 38692092 Free PMC article. Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair. Wu X, Zheng L, Reboll MR, Hyde LF, Mass E, Niessen HW, Kosanke M, Pich A, Giannitsis E, Tillmanns J, Bauersachs J, Heineke J, Wang Y, Korf-Klingebiel M, Polten F, Wollert KC. Nat Cardiovasc Res. 2024 Feb;3(2):186-202. doi: 10.1038/s44161-023-00411-x. Epub 2024 Jan 17. PMID: 39196188 Free PMC article. 2023 Scalable generation of functional human iPSC-derived CAR-macrophages that efficiently eradicate CD19-positive leukemia. Abdin SM, Paasch D, Kloos A, Oliveira MC, Jang MS, Ackermann M, Stamopoulou A, Mroch PJ, Falk CS, von Kaisenberg CS, Schambach A, Heuser M, Moritz T, Hansen G, Morgan M, Lachmann N. J Immunother Cancer. 2023 Dec 22;11(12):e007705. doi: 10.1136/jitc-2023-007705. PMID: 38135346 Free PMC article. MCK2-mediated MCMV infection of macrophages and virus dissemination to the salivary gland depends on MHC class I molecules. Bošnjak B, Henze E, Lueder Y, Do KTH, Rezalotfi A, Čuvalo B, Ritter C, Schimrock A, Willenzon S, Georgiev H, Fritz L, Galla M, Wagner K, Messerle M, Förster R. Cell Rep. 2023 Jun 27;42(6):112597. doi: 10.1016/j.celrep.2023.112597. Epub 2023 Jun 7. PMID: 37289588 Free article. Non-viral TRAC -knocked-in CD19KICAR-T and gp350KICAR-T cells tested against Burkitt lymphomas with type 1 or 2 EBV infection: In vivo cellular dynamics and potency. Braun T, Pruene A, Darguzyte M, Vom Stein AF, Nguyen PH, Wagner DL, Kath J, Roig-Merino A, Heuser M, Riehm LL, Schneider A, Awerkiew S, Talbot SR, Bleich A, Figueiredo C, Bornhäuser M, Stripecke R. Front Immunol. 2023 Mar 24;14:1086433. doi: 10.3389/fimmu.2023.1086433. eCollection 2023. PMID: 37033919 Supraphysiological FOXP3 expression in human CAR-Tregs results in improved stability, efficacy, and safety of CAR-Treg products for clinical application. Henschel P, Landwehr-Kenzel S, Engels N, Schienke A, Kremer J, Riet T, Redel N, Iordanidis K, Saetzler V, John K, Heider M, Hardtke-Wolenski M, Wedemeyer H, Jaeckel E, Noyan F. J Autoimmun. 2023 Jul;138:103057. doi: 10.1016/j.jaut.2023.103057. Epub 2023 May 23. PMID: 37224732 Free article. Single cell RNA sequencing reveals distinct clusters of Irf8-expressing pulmonary conventional dendritic cells. Jirmo AC, Grychtol R, Gaedcke S, Liu B, DeStefano S, Happle C, Halle O, Monteiro JT, Habener A, Breiholz OD, DeLuca D, Hansen G. Front Immunol. 2023 May 12;14:1127485. doi: 10.3389/fimmu.2023.1127485. eCollection 2023. PMID: 37251386 Free PMC article. Individual Epitope-Specific CD8+ T Cell Immune Responses Are Shaped Differently during Chronic Viral Infection. Klein S, Mischke J, Beruldsen F, Prinz I, Antunes DA, Cornberg M, Kraft ARM. Pathogens. 2023 May 14;12(5):716. doi: 10.3390/pathogens12050716. PMID: 37242386 Free PMC article. A pro B cell population forms the apex of the leukemic hierarchy in Hoxa9/Meis1-dependent AML. Lieske A, Agyeman-Duah E, Selich A, Dörpmund N, Talbot SR, Schambach A, Maetzig T. Leukemia. 2023 Jan;37(1):79-90. doi: 10.1038/s41375-022-01775-y. Epub 2022 Dec 14. PMID: 36517672 Free PMC article. CAR-NK Cells Targeting HER1 (EGFR) Show Efficient Anti-Tumor Activity against Head and Neck Squamous Cell Carcinoma (HNSCC). Nowak J, Bentele M, Kutle I, Zimmermann K, Lühmann JL, Steinemann D, Kloess S, Koehl U, Roßberg W, Ahmed A, Schaudien D, Neubert L, Kamp JC, Kuehnel MP, Warnecke A, Schambach A, Morgan M. Cancers (Basel). 2023 Jun 13;15(12):3169. doi: 10.3390/cancers15123169. PMID: 37370779 Free PMC article. Expression of viral CD45 ligand E3/49K on porcine cells reduces human anti-pig immune responses. Pokoyski C, Baars W, Windheim M, Reubold TF, Zischke J, Brinkmann A, Kay-Fedorov PC, Schwinzer R. Sci Rep. 2023 Oct 11;13(1):17218. doi: 10.1038/s41598-023-44316-y. PMID: 37821577 Free PMC article. Downregulation of Swine Leukocyte Antigen Expression Decreases the Strength of Xenogeneic Immune Responses towards Renal Proximal Tubular Epithelial Cells. Schmalkuche K, Schwinzer R, Wenzel N, Valdivia E, Petersen B, Blasczyk R, Figueiredo C. Int J Mol Sci. 2023 Aug 12;24(16):12711. doi: 10.3390/ijms241612711. PMID: 37628892 Free PMC article. Pleural CD14+ monocytes/macrophages of healthy adolescents show a high expression of metallothionein family genes. Schukfeh N, Liu B, DeLuca DS, Tumpara S, Nikolin C, Immenschuh S, Ure BM, Kuebler JF, Welte T, Viemann D, Janciauskiene SM, Vieten G. Eur J Immunol. 2023 Jan;53(1):e2250019. doi: 10.1002/eji.202250019. Epub 2022 Nov 18. PMID: 36321537 Free article. Autolysosomal activation combined with lysosomal destabilization efficiently targets myeloid leukemia cells for cell death. Shah H, Stankov M, Panayotova-Dimitrova D, Yazdi A, Budida R, Klusmann JH, Behrens GMN. Front Oncol. 2023 Feb 1;13:999738. doi: 10.3389/fonc.2023.999738. eCollection 2023. PMID: 36816923 Free PMC article. Permissive ureter specification by TBX18-mediated repression of metanephric gene expression. Weiss AC, Blank E, Bohnenpoll T, Kleppa MJ, Rivera-Reyes R, Taketo MM, Trowe MO, Kispert A. Development. 2023 Mar 15;150(6):dev201048. doi: 10.1242/dev.201048. Epub 2023 Mar 23. PMID: 36960826 RORγt+ c-Maf+ Vγ4+ γδ T cells are generated in the adult thymus but do not reach the periphery. Yang T, Barros-Martins J, Wang Z, Wencker M, Zhang J, Smout J, Gambhir P, Janssen A, Schimrock A, Georgiev H, León-Lara X, Weiss S, Huehn J, Prinz I, Krueger A, Foerster R, Walzer T, Ravens S. Cell Rep. 2023 Oct 31;42(10):113230. doi: 10.1016/j.celrep.2023.113230. Epub 2023 Oct 9. PMID: 37815917 Free article. 2022 Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR-Cas9 into target cells. Baron Y, Sens J, Lange L, Nassauer L, Klatt D, Hoffmann D, Kleppa MJ, Barbosa PV, Keisker M, Steinberg V, Suerth JD, Vondran FWR, Meyer J, Morgan M, Schambach A, Galla M. Mol Ther Nucleic Acids. 2022 Jan 1;27:810-823. doi: 10.1016/j.omtn.2021.12.033. eCollection 2022 Mar 8. PMID: 35141043 Free PMC article. Profiling of epigenetic marker regions in murine ILCs under homeostatic and inflammatory conditions. Beckstette M, Lu CW, Herppich S, Diem EC, Ntalli A, Ochel A, Kruse F, Pietzsch B, Neumann K, Huehn J, Floess S, Lochner M. J Exp Med. 2022 Oct 3;219(10):e20210663. doi: 10.1084/jem.20210663. Epub 2022 Aug 8. PMID: 35938981 Free PMC article. PD-1/CTLA-4 Blockade Leads to Expansion of CD8+PD-1int TILs and Results in Tumor Remission in Experimental Liver Cancer. Bufe S, Zimmermann A, Ravens S, Prinz I, Buitrago-Molina LE, Geffers R, Woller N, Kühnel F, Talbot SR, Noyan F, Manns MP, Wedemeyer H, Hardtke-Wolenski M, Jaeckel E, Davalos-Misslitz AC. Liver Cancer. 2022 Oct 7;12(2):129-144. doi: 10.1159/000526899. eCollection 2023 Jun. PMID: 37325488 Free PMC article. Proinflammatory cytokines induce rapid, NO-independent apoptosis, expression of chemotactic mediators and interleukin-32 secretion in human pluripotent stem cell-derived beta cells. Dettmer R, Niwolik I, Cirksena K, Yoshimoto T, Tang Y, Mehmeti I, Gurgul-Convey E, Naujok O. Diabetologia. 2022 May;65(5):829-843. doi: 10.1007/s00125-022-05654-0. Epub 2022 Feb 5. PMID: 35122482 Free PMC article. Specific T cells targeting Staphylococcus aureus fibronectin-binding protein 1 induce a type 2/type 1 inflammatory response in sensitized atopic dermatitis patients. Farag AK, Roesner LM, Wieschowski S, Heratizadeh A, Eiz-Vesper B, Kwok WW, Valenta R, Werfel T. Allergy. 2022 Apr;77(4):1245-1253. doi: 10.1111/all.15120. Epub 2021 Oct 22. PMID: 34601735 Free PMC article. Loss of vascular endothelial notch signaling promotes spontaneous formation of tertiary lymphoid structures. Fleig S, Kapanadze T, Bernier-Latmani J, Lill JK, Wyss T, Gamrekelashvili J, Kijas D, Liu B, Hüsing AM, Bovay E, Jirmo AC, Halle S, Ricke-Hoch M, Adams RH, Engel DR, von Vietinghoff S, Förster R, Hilfiker-Kleiner D, Haller H, Petrova TV, Limbourg FP. Nat Commun. 2022 Apr 19;13(1):2022. doi: 10.1038/s41467-022-29701-x. PMID: 35440634 Free PMC article. Airway basal cells show a dedifferentiated KRT17highPhenotype and promote fibrosis in idiopathic pulmonary fibrosis. Jaeger B, Schupp JC, Plappert L, Terwolbeck O, Artysh N, Kayser G, Engelhard P, Adams TS, Zweigerdt R, Kempf H, Lienenklaus S, Garrels W, Nazarenko I, Jonigk D, Wygrecka M, Klatt D, Schambach A, Kaminski N, Prasse A. Nat Commun. 2022 Sep 26;13(1):5637. doi: 10.1038/s41467-022-33193-0. PMID: 36163190 Free PMC article. Membrane-bound IL-2 improves the expansion, survival, and phenotype of CAR Tregs and confers resistance to calcineurin inhibitors. Kremer J, Henschel P, Simon D, Riet T, Falk C, Hardtke-Wolenski M, Wedemeyer H, Noyan F, Jaeckel E. Front Immunol. 2022 Dec 23;13:1005582. doi: 10.3389/fimmu.2022.1005582. eCollection 2022. PMID: 36618378 Free PMC article. Acetyl-CoA-Carboxylase 1-mediated de novo fatty acid synthesis sustains Lgr5+ intestinal stem cell function. Li S, Lu CW, Diem EC, Li W, Guderian M, Lindenberg M, Kruse F, Buettner M, Floess S, Winny MR, Geffers R, Richnow HH, Abraham WR, Grassl GA, Lochner M. Nat Commun. 2022 Jul 9;13(1):3998. doi: 10.1038/s41467-022-31725-2. PMID: 35810180 Free PMC article. Real-Time Characterization of Clonal Fate Decisions in Complex Leukemia Samples by Fluorescent Genetic Barcoding. Maetzig T, Lieske A, Dörpmund N, Rothe M, Kleppa MJ, Dziadek V, Hassan JJ, Dahlke J, Borchert D, Schambach A. Cells. 2022 Dec 14;11(24):4045. doi: 10.3390/cells11244045. PMID: 36552809 Free PMC article. B cell-mediated regulatory mechanisms control tumor-promoting intestinal inflammation. Melcher C, Yu J, Duong VHH, Westphal K, Helmi Siasi Farimany N, Shaverskyi A, Zhao B, Strowig T, Glage S, Brand K, Chan AC, Föger N, Lee KH. Cell Rep. 2022 Jul 12;40(2):111051. doi: 10.1016/j.celrep.2022.111051. PMID: 35830810 Free article. Cross-Reactive T Cell Response Exists in Chronic Lymphocytic Choriomeningitis Virus Infection upon Pichinde Virus Challenge. Mischke J, Klein S, Seamann A, Prinz I, Selin L, Ghersi D, Cornberg M, Kraft ARM. Viruses. 2022 Oct 18;14(10):2293. doi: 10.3390/v14102293. PMID: 36298848 Free PMC article. Ex Vivo Generation of CAR Macrophages from Hematopoietic Stem and Progenitor Cells for Use in Cancer Therapy. Paasch D, Meyer J, Stamopoulou A, Lenz D, Kuehle J, Kloos D, Buchegger T, Holzinger A, Falk CS, Kloth C, von Kaisenberg CS, Abken H, Schambach A, Lachmann N, Morgan M, Moritz T. Cells. 2022 Mar 15;11(6):994. doi: 10.3390/cells11060994. PMID: 35326445 Free PMC article. T-cell receptor sequencing specifies psoriasis as a systemic and atopic dermatitis as a skin-focused, allergen-driven disease. Roesner LM, Farag AK, Pospich R, Traidl S, Werfel T. Allergy. 2022 Sep;77(9):2737-2747. doi: 10.1111/all.15272. Epub 2022 Mar 14. PMID: 35255168 Healthy-like CD4+ Regulatory and CD4+ Conventional T-Cell Receptor Repertoires Predict Protection from GVHD Following Donor Lymphocyte Infusion. Schneider J, Kuhlmann L, Xiao Y, Raha S, Bernhardt G, Stadler M, Thol F, Heuser M, Eder M, Ganser A, Ravens S, Förster R, Prinz I, Koenecke C, Schultze-Florey CR. Int J Mol Sci. 2022 Sep 18;23(18):10914. doi: 10.3390/ijms231810914. PMID: 36142824 Free PMC article. Targeted biallelic integration of an inducible Caspase 9 suicide gene in iPSCs for safer therapies. Wunderlich S, Haase A, Merkert S, Jahn K, Deest M, Frieling H, Glage S, Korte W, Martens A, Kirschning A, Zeug A, Ponimaskin E, Göhring G, Ackermann M, Lachmann N, Moritz T, Zweigerdt R, Martin U. Mol Ther Methods Clin Dev. 2022 May 31;26:84-94. doi: 10.1016/j.omtm.2022.05.011. eCollection 2022 Sep 8. PMID: 35795779 Free PMC article. 2021 A 3D iPSC-differentiation model identifies interleukin-3 as a regulator of early human hematopoietic specification. Ackermann M, Haake K, Kempf H, Kaschutnig P, Weiss AC, Nguyen AHH, Abeln M, Merkert S, Kühnel MP, Hartmann D, Jonigk D, Thum T, Kispert A, Milsom MD, Lachmann N. Haematologica. 2021 May 1;106(5):1354-1367. doi: 10.3324/haematol.2019.228064. PMID: 32327499 Free PMC article. Efficient Genetic Safety Switches for Future Application of iPSC-Derived Cell Transplants. Dahlke J, Schott JW, Vollmer Barbosa P, Klatt D, Selich A, Lachmann N, Morgan M, Moritz T, Schambach A. J Pers Med. 2021 Jun 17;11(6):565. doi: 10.3390/jpm11060565. PMID: 34204193 Free PMC article. Lymph-Derived Neutrophils Primarily Locate to the Subcapsular and Medullary Sinuses in Resting and Inflamed Lymph Nodes. de Castro Pinho J, Förster R. Cells. 2021 Jun 12;10(6):1486. doi: 10.3390/cells10061486. PMID: 34204825 Free PMC article. New hPSC SOX9 and INS Reporter Cell Lines Facilitate the Observation and Optimization of Differentiation into Insulin-Producing Cells. Dettmer R, Niwolik I, Mehmeti I, Jörns A, Naujok O. Stem Cell Rev Rep. 2021 Dec;17(6):2193-2209. doi: 10.1007/s12015-021-10232-9. Epub 2021 Aug 19. PMID: 34415483 Free PMC article. A selectable all-in-one CRISPR prime editing piggyBac transposon allows for highly efficient gene editing in human cell lines. Eggenschwiler R, Gschwendtberger T, Felski C, Jahn C, Langer F, Sterneckert J, Hermann A, Lühmann J, Steinemann D, Haase A, Martin U, Petri S, Cantz T. Sci Rep. 2021 Nov 12;11(1):22154. doi: 10.1038/s41598-021-01689-2. PMID: 34773059 Free PMC article. Expansion of CD10neg neutrophils and CD14+HLA-DRneg/low monocytes driving proinflammatory responses in patients with acute myocardial infarction. Fraccarollo D, Neuser J, Möller J, Riehle C, Galuppo P, Bauersachs J. Elife. 2021 Jul 22;10:e66808. doi: 10.7554/eLife.66808. PMID: 34289931 Free PMC article. Multiple Genes Surrounding Bcl-xL , a Common Retroviral Insertion Site, Can Influence Hematopoiesis Individually or in Concert. Ha TC, Stahlhut M, Rothe M, Paul G, Dziadek V, Morgan M, Brugman M, Fehse B, Kustikova O, Schambach A, Baum C. Hum Gene Ther. 2021 May;32(9-10):458-472. doi: 10.1089/hum.2019.344. Epub 2020 Dec 7. PMID: 33012194 Regulatory B cells control airway hyperreactivity and lung remodeling in a murine asthma model. Habener A, Happle C, Grychtol R, Skuljec J, Busse M, Dalüge K, Obernolte H, Sewald K, Braun A, Meyer-Bahlburg A, Hansen G. J Allergy Clin Immunol. 2021 Jun;147(6):2281-2294.e7. doi: 10.1016/j.jaci.2020.09.041. Epub 2020 Nov 27. PMID: 33249168 A Multiplex CRISPR-Screen Identifies PLA2G4A as Prognostic Marker and Druggable Target for HOXA9 and MEIS1 Dependent AML. Hassan JJ, Lieske A, Dörpmund N, Klatt D, Hoffmann D, Kleppa MJ, Kustikova OS, Stahlhut M, Schwarzer A, Schambach A, Maetzig T. Int J Mol Sci. 2021 Aug 30;22(17):9411. doi: 10.3390/ijms22179411. PMID: 34502319 Free PMC article. Peritoneal dialysate-range hypertonic glucose promotes T-cell IL-17 production that induces mesothelial inflammation. Helmke A, Hüsing AM, Gaedcke S, Brauns N, Balzer MS, Reinhardt M, Hiss M, Shushakova N, de Luca D, Prinz I, Haller H, von Vietinghoff S. Eur J Immunol. 2021 Feb;51(2):354-367. doi: 10.1002/eji.202048733. Epub 2020 Sep 30. PMID: 32926407 Free article. Genetic Correction of IL-10RB Deficiency Reconstitutes Anti-Inflammatory Regulation in iPSC-Derived Macrophages. Hoffmann D, Sens J, Brennig S, Brand D, Philipp F, Vollmer Barbosa P, Kuehle J, Steinemann D, Lenz D, Buchegger T, Morgan M, Falk CS, Klein C, Lachmann N, Schambach A. J Pers Med. 2021 Mar 20;11(3):221. doi: 10.3390/jpm11030221. PMID: 33804706 Free PMC article. Pulmonary transplantation of alpha-1 antitrypsin (AAT)-transgenic macrophages provides a source of functional human AAT in vivo. Janosz E, Hetzel M, Spielmann H, Tumpara S, Rossdam C, Schwabbauer M, Kloos D, von Kaisenberg C, Schambach A, Buettner FFR, Janciauskiene S, Lachmann N, Moritz T. Gene Ther. 2021 Sep;28(9):477-493. doi: 10.1038/s41434-021-00269-3. Epub 2021 Jul 19. PMID: 34276045 Free PMC article. Review. Venetoclax and dexamethasone synergize with inotuzumab ozogamicin-induced DNA damage signaling in B-lineage ALL. Kirchhoff H, Karsli U, Schoenherr C, Battmer K, Erschow S, Talbot SR, Steinemann D, Heuser M, Heidenreich O, Hilfiker-Kleiner D, Ganser A, Eder M, Scherr M. Blood. 2021 May 13;137(19):2657-2661. doi: 10.1182/blood.2020008544. PMID: 33512436 Free PMC article. Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca2+-ATPase Expression in Cardiomyocytes. Korf-Klingebiel M, Reboll MR, Polten F, Weber N, Jäckle F, Wu X, Kallikourdis M, Kunderfranco P, Condorelli G, Giannitsis E, Kustikova OS, Schambach A, Pich A, Widder JD, Bauersachs J, van den Heuvel J, Kraft T, Wang Y, Wollert KC. Circulation. 2021 Oct 12;144(15):1227-1240. doi: 10.1161/CIRCULATIONAHA.120.053365. Epub 2021 Aug 10. PMID: 34372689 An Improved Lentiviral Fluorescent Genetic Barcoding Approach Distinguishes Hematopoietic Stem Cell Properties in Multiplexed In Vivo Experiments. Lieske A, Ha TC, Schambach A, Maetzig T. Hum Gene Ther. 2021 Oct;32(19-20):1280-1294. doi: 10.1089/hum.2021.042. PMID: 34139894 Improved Activity against Acute Myeloid Leukemia with Chimeric Antigen Receptor (CAR)-NK-92 Cells Designed to Target CD123. Morgan MA, Kloos A, Lenz D, Kattre N, Nowak J, Bentele M, Keisker M, Dahlke J, Zimmermann K, Sauer M, Heuser M, Schambach A. Viruses. 2021 Jul 14;13(7):1365. doi: 10.3390/v13071365. PMID: 34372571 Free PMC article. Differential retention of lymph-borne CD8 memory T cell subsets in the subcapsular sinus of resting and inflamed lymph nodes. Nikolova G, Weiss S, Bosnjak B, Förster R. Cell Mol Immunol. 2021 May;18(5):1317-1319. doi: 10.1038/s41423-020-0451-6. Epub 2020 May 12. PMID: 32398805 Free PMC article. No abstract available. Efficient IL-2R signaling differentially affects the stability, function, and composition of the regulatory T-cell pool. Permanyer M, Bošnjak B, Glage S, Friedrichsen M, Floess S, Huehn J, Patzer GE, Odak I, Eckert N, Zargari R, Ospina-Quintero L, Georgiev H, Förster R. Cell Mol Immunol. 2021 Feb;18(2):398-414. doi: 10.1038/s41423-020-00599-z. Epub 2021 Jan 6. PMID: 33408345 Free PMC article. Human CD16+ monocytes promote a pro-atherosclerotic endothelial cell phenotype via CX3CR1-CX3CL1 interaction. Roy-Chowdhury E, Brauns N, Helmke A, Nordlohne J, Bräsen JH, Schmitz J, Volkmann J, Fleig SV, Kusche-Vihrog K, Haller H, von Vietinghoff S. Cardiovasc Res. 2021 May 25;117(6):1510-1522. doi: 10.1093/cvr/cvaa234. PMID: 32717023 Generation of an NFκB-Driven Alpharetroviral "All-in-One" Vector Construct as a Potent Tool for CAR NK Cell Therapy. Rudek LS, Zimmermann K, Galla M, Meyer J, Kuehle J, Stamopoulou A, Brand D, Sandalcioglu IE, Neyazi B, Moritz T, Rossig C, Altvater B, Falk CS, Abken H, Morgan MA, Schambach A. Front Immunol. 2021 Nov 3;12:751138. doi: 10.3389/fimmu.2021.751138. eCollection 2021. PMID: 34804035 Free PMC article. Clonal expansion of CD8+ T cells reflects graft-versus-leukemia activity and precedes durable remission following DLI. Schultze-Florey CR, Kuhlmann L, Raha S, Barros-Martins J, Odak I, Tan L, Xiao Y, Ravens S, Hambach L, Venturini L, Stadler M, Eder M, Thol F, Heuser M, Förster R, Ganser A, Prinz I, Koenecke C. Blood Adv. 2021 Nov 9;5(21):4485-4499. doi: 10.1182/bloodadvances.2020004073. PMID: 34535011 Free PMC article. Knockout-Induced Pluripotent Stem Cells for Disease and Therapy Modeling of IL-10-Associated Primary Immunodeficiencies. Sens J, Hoffmann D, Lange L, Vollmer Barbosa P, Morgan M, Falk CS, Schambach A. Hum Gene Ther. 2021 Jan;32(1-2):77-95. doi: 10.1089/hum.2020.235. Epub 2021 Jan 11. PMID: 33023317 Conditionally immortalised leukaemia initiating cells co-expressing Hoxa9/Meis1 demonstrate microenvironmental adaptation properties ex vivo while maintaining myelomonocytic memory. Stahlhut M, Ha TC, Takmakova E, Morgan MA, Schwarzer A, Schaudien D, Eder M, Schambach A, Kustikova OS. Sci Rep. 2021 Mar 5;11(1):5294. doi: 10.1038/s41598-021-84468-3. PMID: 33674652 Free PMC article. Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp. Werth K, Hub E, Gutjahr JC, Bosjnak B, Zheng X, Bubke A, Russo S, Rot A, Förster R. Cell Rep. 2021 Jul 13;36(2):109346. doi: 10.1016/j.celrep.2021.109346. PMID: 34260918 Free article. Targeted delivery of regulatory macrophages to lymph nodes interferes with T cell priming by preventing the formation of stable immune synapses. Yu K, Hammerschmidt SI, Permanyer M, Galla M, Rothe M, Zheng X, Werth K, Martens R, Lueder Y, Janssen A, Friedrichsen M, Bernhardt G, Förster R. Cell Rep. 2021 Jun 22;35(12):109273. doi: 10.1016/j.celrep.2021.109273. PMID: 34161766 Free article. 2020 B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression. Eckert N, Werth K, Willenzon S, Tan L, Förster R. J Leukoc Biol. 2020 Jun;107(6):1155-1166. doi: 10.1002/JLB.2MA1119-300R. Epub 2019 Dec 16. PMID: 31841228 TCR repertoire analysis reveals phosphoantigen-induced polyclonal proliferation of Vγ9Vδ2 T cells in neonates and adults. # Fichtner AS, Bubke A, Rampoldi F, Wilharm A, Tan L, Steinbrück L, Schultze-Florey C, von Kaisenberg C, Prinz I, Herrmann T, Ravens S. J Leukoc Biol. 2020 Jun;107(6):1023-1032. doi: 10.1002/JLB.1MA0120-427RR. Epub 2020 Feb 17. PMID: 32064671 Human Lentiviral Gene Therapy Restores the Cellular Phenotype of Autosomal Recessive Complete IFN-γR1 Deficiency. Hahn K, Pollmann L, Nowak J, Nguyen AHH, Haake K, Neehus AL, Waqas SFH, Pessler F, Baumann U, Hetzel M, Casanova JL, Schulz A, Bustamante J, Ackermann M, Lachmann N. Mol Ther Methods Clin Dev. 2020 Apr 11;17:785-795. doi: 10.1016/j.omtm.2020.04.002. eCollection 2020 Jun 12. PMID: 32355867 Free PMC article. Effective hematopoietic stem cell-based gene therapy in a murine model of hereditary pulmonary alveolar proteinosis. Hetzel M, Lopez-Rodriguez E, Mucci A, Nguyen AHH, Suzuki T, Shima K, Buchegger T, Dettmer S, Rodt T, Bankstahl JP, Malik P, Knudsen L, Schambach A, Hansen G, Trapnell BC, Lachmann N, Moritz T. Haematologica. 2020 Apr;105(4):1147-1157. doi: 10.3324/haematol.2018.214866. Epub 2019 Jul 9. PMID: 31289207 Free PMC article. IL-17 regulates DC migration to the peribronchial LNs and allergen presentation in experimental allergic asthma. Jirmo AC, Busse M, Happle C, Skuljec J, Dalüge K, Habener A, Grychtol R, DeLuca DS, Breiholz OD, Prinz I, Hansen G. Eur J Immunol. 2020 Jul;50(7):1019-1033. doi: 10.1002/eji.201948409. Epub 2020 Mar 29. PMID: 32142593 Free article. Effective drug treatment identified by in vivo screening in a transplantable patient-derived xenograft model of chronic myelomonocytic leukemia. Kloos A, Mintzas K, Winckler L, Gabdoulline R, Alwie Y, Jyotsana N, Kattre N, Schottmann R, Scherr M, Gupta C, Adams FF, Schwarzer A, Heckl D, Schambach A, Imren S, Humphries RK, Ganser A, Thol F, Heuser M. Leukemia. 2020 Nov;34(11):2951-2963. doi: 10.1038/s41375-020-0929-3. Epub 2020 Jun 24. PMID: 32576961 Free PMC article. Targeted Integration of Inducible Caspase-9 in Human iPSCs Allows Efficient in vitro Clearance of iPSCs and iPSC-Macrophages. Lipus A, Janosz E, Ackermann M, Hetzel M, Dahlke J, Buchegger T, Wunderlich S, Martin U, Cathomen T, Schambach A, Moritz T, Lachmann N. Int J Mol Sci. 2020 Apr 3;21(7):2481. doi: 10.3390/ijms21072481. PMID: 32260086 Free PMC article. Efficient homing of T cells via afferent lymphatics requires mechanical arrest and integrin-supported chemokine guidance. Martens R, Permanyer M, Werth K, Yu K, Braun A, Halle O, Halle S, Patzer GE, Bošnjak B, Kiefer F, Janssen A, Friedrichsen M, Poetzsch J, Kohli K, Lueder Y, Gutierrez Jauregui R, Eckert N, Worbs T, Galla M, Förster R. Nat Commun. 2020 Feb 28;11(1):1114. doi: 10.1038/s41467-020-14921-w. PMID: 32111837 Free PMC article. Electroconvulsive therapy, changes in immune cell ratios, and their association with seizure quality and clinical outcome in depressed patients. Moschny N, Jahn K, Maier HB, Khan AQ, Ballmaier M, Liepach K, Sack M, Skripuletz T, Bleich S, Frieling H, Neyazi A. Eur Neuropsychopharmacol. 2020 Jul;36:18-28. doi: 10.1016/j.euroneuro.2020.03.019. Epub 2020 May 21. PMID: 32446707 DNA Methylation of the t-PA Gene Differs Between Various Immune Cell Subtypes Isolated From Depressed Patients Receiving Electroconvulsive Therapy. Moschny N, Jahn K, Bajbouj M, Maier HB, Ballmaier M, Khan AQ, Pollak C, Bleich S, Frieling H, Neyazi A. Front Psychiatry. 2020 Jun 19;11:571. doi: 10.3389/fpsyt.2020.00571. eCollection 2020. PMID: 32636772 Free PMC article. Mutations of the gene FNIP1 associated with a syndromic autosomal recessive immunodeficiency with cardiomyopathy and pre-excitation syndrome. Niehues T, Özgür TT, Bickes M, Waldmann R, Schöning J, Bräsen J, Hagel C, Ballmaier M, Klusmann JH, Niedermayer A, Pannicke U, Enders A, Dückers G, Siepermann K, Hempel J, Schwarz K, Viemann D. Eur J Immunol. 2020 Jul;50(7):1078-1080. doi: 10.1002/eji.201948504. Epub 2020 Apr 20. PMID: 32181500 Free article. Microbial exposure drives polyclonal expansion of innate γδ T cells immediately after birth. Ravens S, Fichtner AS, Willers M, Torkornoo D, Pirr S, Schöning J, Deseke M, Sandrock I, Bubke A, Wilharm A, Dodoo D, Egyir B, Flanagan KL, Steinbrück L, Dickinson P, Ghazal P, Adu B, Viemann D, Prinz I. Proc Natl Acad Sci U S A. 2020 Aug 4;117(31):18649-18660. doi: 10.1073/pnas.1922588117. Epub 2020 Jul 20. PMID: 32690687 Free PMC article. Meningioma 1 is indispensable for mixed lineage leukemia-rearranged acute myeloid leukemia. Sharma A, Jyotsana N, Gabdoulline R, Heckl D, Kuchenbauer F, Slany RK, Ganser A, Heuser M. Haematologica. 2020 May;105(5):1294-1305. doi: 10.3324/haematol.2018.211201. Epub 2019 Aug 14. PMID: 31413090 Free PMC article. Dual Function of iPSC-Derived Pericyte-Like Cells in Vascularization and Fibrosis-Related Cardiac Tissue Remodeling In Vitro. Szepes M, Melchert A, Dahlmann J, Hegermann J, Werlein C, Jonigk D, Haverich A, Martin U, Olmer R, Gruh I. Int J Mol Sci. 2020 Nov 25;21(23):8947. doi: 10.3390/ijms21238947. PMID: 33255686 Free PMC article. S100A8 and S100A9 Are Important for Postnatal Development of Gut Microbiota and Immune System in Mice and Infants. Willers M, Ulas T, Völlger L, Vogl T, Heinemann AS, Pirr S, Pagel J, Fehlhaber B, Halle O, Schöning J, Schreek S, Löber U, Essex M, Hombach P, Graspeuntner S, Basic M, Bleich A, Cloppenborg-Schmidt K, Künzel S, Jonigk D, Rupp J, Hansen G, Förster R, Baines JF, Härtel C, Schultze JL, Forslund SK, Roth J, Viemann D. Gastroenterology. 2020 Dec;159(6):2130-2145.e5. doi: 10.1053/j.gastro.2020.08.019. Epub 2020 Aug 15. PMID: 32805279 Free article. 2019 The stem cell-specific long noncoding RNA HOXA10-AS in the pathogenesis of KMT2A-rearranged leukemia. Al-Kershi S, Bhayadia R, Ng M, Verboon L, Emmrich S, Gack L, Schwarzer A, Strowig T, Heckl D, Klusmann JH. Blood Adv. 2019 Dec 23;3(24):4252-4263. doi: 10.1182/bloodadvances.2019032029. PMID: 31867596 Free PMC article. Chemically defined and xenogeneic-free differentiation of human pluripotent stem cells into definitive endoderm in 3D culture. Diekmann U, Wolling H, Dettmer R, Niwolik I, Naujok O, Buettner FFR. Sci Rep. 2019 Jan 30;9(1):996. doi: 10.1038/s41598-018-37650-z. PMID: 30700818 Free PMC article. B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression. Eckert N, Werth K, Willenzon S, Tan L, Förster R. J Leukoc Biol. 2020 Jun;107(6):1155-1166. doi: 10.1002/JLB.2MA1119-300R. Epub 2019 Dec 16. PMID: 31841228 Macrophage Mineralocorticoid Receptor Is a Pleiotropic Modulator of Myocardial Infarct Healing. Fraccarollo D, Thomas S, Scholz CJ, Hilfiker-Kleiner D, Galuppo P, Bauersachs J. Hypertension. 2019 Jan;73(1):102-111. doi: 10.1161/HYPERTENSIONAHA.118.12162. PMID: 30543467 Free PMC article. CX3CL1-CX3CR1 interaction mediates macrophage-mesothelial cross talk and promotes peritoneal fibrosis. Helmke A, Nordlohne J, Balzer MS, Dong L, Rong S, Hiss M, Shushakova N, Haller H, von Vietinghoff S. Kidney Int. 2019 Jun;95(6):1405-1417. doi: 10.1016/j.kint.2018.12.030. Epub 2019 Mar 5. PMID: 30948201 Free article. Heparan Sulfate-Editing Extracellular Sulfatases Enhance VEGF Bioavailability for Ischemic Heart Repair. Korf-Klingebiel M, Reboll MR, Grote K, Schleiner H, Wang Y, Wu X, Klede S, Mikhed Y, Bauersachs J, Klintschar M, Rudat C, Kispert A, Niessen HW, Lübke T, Dierks T, Wollert KC. Circ Res. 2019 Oct 11;125(9):787-801. doi: 10.1161/CIRCRESAHA.119.315023. Epub 2019 Aug 22. PMID: 31434553 Free article. Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo. Jyotsana N, Sharma A, Chaturvedi A, Budida R, Scherr M, Kuchenbauer F, Lindner R, Noyan F, Sühs KW, Stangel M, Grote-Koska D, Brand K, Vornlocher HP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M. Ann Hematol. 2019 Aug;98(8):1905-1918. doi: 10.1007/s00277-019-03713-y. Epub 2019 May 18. PMID: 31104089 Free PMC article. Mechanisms of Progression of Myeloid Preleukemia to Transformed Myeloid Leukemia in Children with Down Syndrome. Labuhn M, Perkins K, Matzk S, Varghese L, Garnett C, Papaemmanuil E, Metzner M, Kennedy A, Amstislavskiy V, Risch T, Bhayadia R, Samulowski D, Hernandez DC, Stoilova B, Iotchkova V, Oppermann U, Scheer C, Yoshida K, Schwarzer A, Taub JW, Crispino JD, Weiss MJ, Hayashi Y, Taga T, Ito E, Ogawa S, Reinhardt D, Yaspo ML, Campbell PJ, Roberts I, Constantinescu SN, Vyas P, Heckl D, Klusmann JH. Cancer Cell. 2019 Aug 12;36(2):123-138.e10. doi: 10.1016/j.ccell.2019.06.007. Epub 2019 Jul 11. PMID: 31303423 Free PMC article. Focusing of the regulatory T-cell repertoire after allogeneic stem cell transplantation indicates protection from graft- versus -host disease. Odak I, Raha S, Schultze-Florey C, Tavil S, Ravens S, Ganser A, Förster R, Prinz I, Koenecke C. Haematologica. 2019 Dec;104(12):e577-e580. doi: 10.3324/haematol.2019.218206. Epub 2019 Apr 24. PMID: 31018979 Free PMC article. No abstract available. Single-Cell Transcriptomics Identifies the Adaptation of Scart1+ Vγ6+ T Cells to Skin Residency as Activated Effector Cells. Tan L, Sandrock I, Odak I, Aizenbud Y, Wilharm A, Barros-Martins J, Tabib Y, Borchers A, Amado T, Gangoda L, Herold MJ, Schmidt-Supprian M, Kisielow J, Silva-Santos B, Koenecke C, Hovav AH, Krebs C, Prinz I, Ravens S. Cell Rep. 2019 Jun 18;27(12):3657-3671.e4. doi: 10.1016/j.celrep.2019.05.064. PMID: 31216482 Free article. 2018 Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, Fiedler J, Schwarzer A, Rouhi A, Heuser M, Wingert S, Bothur S, Döhner K, Mätzig T, Ng M, Reinhardt D, Döhner H, Zwaan CM, van den Heuvel Eibrink M, Heckl D, Fornerod M, Thum T, Humphries RK, Rieger MA, Kuchenbauer F, Klusmann JH. Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia. J Clin Oncol. 2018 Apr 1;36(10):1007-1016. Blume, J., Zietara, N., Witzlau, K., Liu, Y., Sanchez, O. O., Puchalka, J., Winter, S. J., Kunze-Schumacher, H., Saran, N., Duber, S., Roy, B., Weiss, S., Klein, C., Wurst, W., Lyszkiewicz, M., and Krueger, A. miR-191 modulates B-cell development and targets transcription factors E2A, Foxp1, and Egr1. Eur J Immunol 49, 121-132. Georgiev H, Ravens I, Papadogianni G, Halle S, Malissen B, Loots GG, Förster R, Bernhardt G. Shared and Unique Features Distinguishing Follicular T Helper and Regulatory Cells of Peripheral Lymph Node and Peyer's Patches. Front Immunol. 2018 Apr 9;9:714. doi: 10.3389/fimmu.2018.00714. eCollection 2018. PubMed PMID: 29686684; PubMed Central PMCID: PMC5900012. Georgiev H, Ravens I, Papadogianni G, Malissen B, Förster R, Bernhardt G. Blocking the ART2.2/P2X7-system is essential to avoid a detrimental bias in functional CD4 T cell studies. Eur J Immunol. 2018 Jun;48(6):1078-1081. doi: 10.1002/eji.201747420. Epub 2018 Mar 23. PubMed PMID: 29508376. Germeshausen M, Ancliff P, Estrada J, Metzler M, Ponstingl E, Rütschle H, Schwabe D, Scott RH, Unal S, Wawer A, Zeller B, Ballmaier M. MECOM-associated syndrome: a heterogeneous inherited bone marrow failure syndrome with amegakaryocytic thrombocytopenia. Blood Adv. 2018 Mar 27;2(6):586-596. doi: 10.1182/bloodadvances.2018016501. PubMed PMID: 29540340; PubMed Central PMCID: PMC5873238. Getzin T, Krishnasamy K, Gamrekelashvili J, Kapanadze T, Limbourg A, Häger C, Napp LC, Bauersachs J, Haller H, Limbourg FP. The chemokine receptor CX(3)CR1 coordinates monocyte recruitment and endothelial regeneration after arterial injury. EMBO Mol Med. 2018 Feb;10(2):151-159. Gialesaki S, Mahnken AK, Schmid L, Labuhn M, Bhayadia R, Heckl D, Klusmann JH. GATA1s exerts developmental stage-specific effects in human hematopoiesis. Haematologica. 2018 Aug;103(8):e336-e340. Glaesener S, Jaenke C, Habener A, Geffers R, Hagendorff P, Witzlau K, Imelmann E, Krueger A, Meyer-Bahlburg A. Decreased production of class-switched antibodies in neonatal B cells is associated with increased expression of miR-181b. PLoS One. 2018 Feb 1;13(2):e0192230. doi: 10.1371/journal.pone.0192230. eCollection 2018. PubMed PMID: 29389970; PubMed Central PMCID: PMC5794184. Hammerschmidt SI, Werth K, Rothe M, Galla M, Permanyer M, Patzer GE, Bubke A, Frenk DN, Selich A, Lange L, Schambach A, Bošnjak B, Förster R. CRISPR/Cas9 Immunoengineering of Hoxb8-Immortalized Progenitor Cells for Revealing CCR7-Mediated Dendritic Cell Signaling and Migration Mechanisms in vivo. Front Immunol. 2018 Aug 28;9:1949. doi: 10.3389/fimmu.2018.01949. eCollection 2018. PubMed PMID: 30210501; PubMed Central PMCID: PMC6120996. Happle C, Meyer-Decking L, Dreier A, Wetzke M, Gläsener S, Grychtol R, Braubach P, Jablonka A, Haid S, Jirmo AC, Habener A, Skuljec J, Hansen G. Improved protocol for simultaneous analysis of leukocyte subsets and epithelial cells from murine and human lung. Exp Lung Res. 2018 Apr;44(3):127-136. doi: 10.1080/01902148.2018.1432721. Epub 2018 Apr 20. PMID: 29677457 Free article. Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, Kühnel MP, Billig S, Meineke R, Brand D, Herder V, Baumgärtner W, Bange FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N. Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections. Blood. 2018 Feb 1;131(5):533-545. doi: 10.1182/blood-2017-10-812859. Epub 2017 Dec 12. PubMed PMID: 29233822. Jyotsana N, Sharma A, Chaturvedi A, Scherr M, Kuchenbauer F, Sajti L, Barchanski A, Lindner R, Noyan F, Sühs KW, Grote-Koska D, Brand K, Vornlocher HP, Stanulla M, Bornhauser B, Bourquin JP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M. RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo. Leukemia. 2018 Jan;32(1):224-226. doi: 10.1038/leu.2017.269. Epub 2017 Aug 22. PMID: 28827563 Free PMC article. No abstract available. Melzer C, von der Ohe J, Hass R. Enhanced metastatic capacity of breast cancer cells after interaction and hybrid formation with mesenchymal stroma/stem cells (MSC). Cell Commun Signal. 2018 Jan 5;16(1) Melzer C, von der Ohe J, Hass R. In Vitro Fusion of Normal and Neoplastic Breast Epithelial Cells with Human Mesenchymal Stroma/Stem Cells Partially Involves Tumor Necrosis Factor Receptor Signaling. Stem Cells. 2018 Jul;36(7):977-989. Melzer C, von der Ohe J, Hass R. MSC stimulate ovarian tumor growth during intercellular communication but reduce tumorigenicity after fusion with ovarian cancer cells. Cell Commun Signal. 2018 Oct 13;16(1):67. Raud B, Roy DG, Divakaruni AS, Tarasenko TN, Franke R, Ma EH, Samborska B, Hsieh WY, Wong AH, Stüve P, Arnold-Schrauf C, Guderian M, Lochner M, Rampertaap S, Romito K, Monsale J, Brönstrup M, Bensinger SJ, Murphy AN, McGuire PJ, Jones RG, Sparwasser T, Berod L. Etomoxir Actions on Regulatory and Memory T Cells Are Independent of Cpt1a-Mediated Fatty Acid Oxidation. Cell Metab. 2018 Sep 4;28(3):504-515.e7. doi: 10.1016/j.cmet.2018.06.002. Epub 2018 Jun 28. PubMed PMID: 30043753. Ravens S, Hengst J, Schlapphoff V, Deterding K, Dhingra A, Schultze-Florey C, Koenecke C, Cornberg M, Wedemeyer H, Prinz I. Human γδ T Cell Receptor Repertoires in Peripheral Blood Remain Stable Despite Clearance of Persistent Hepatitis C Virus Infection by Direct-Acting Antiviral Drug Therapy. Front Immunol. 2018 Mar 16;9:510. doi: 10.3389/fimmu.2018.00510. eCollection 2018. PubMed PMID: 29616028; PubMed Central PMCID: PMC5864898. Sandrock I, Reinhardt A, Ravens S, Binz C, Wilharm A, Martins J, Oberdörfer L, Tan L, Lienenklaus S, Zhang B, Naumann R, Zhuang Y, Krueger A, Förster R, Prinz I. Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells. J Exp Med. 2018 Dec 3;215(12):3006-3018. Schultze-Florey RE, Tischer S, Kuhlmann L, Hundsdoerfer P, Koch A,Anagnostopoulos I, Ravens S, Goudeva L, Schultze-Florey C, Koenecke C, Blasczyk R, Koehl U, Heuft HG, Prinz I, Eiz-Vesper B, Maecker-Kolhoff B. Dissecting Epstein-Barr Virus-Specific T-Cell Responses After Allogeneic EBV-Specific T-Cell Transfer for Central Nervous System Posttransplant Lymphoproliferative Disease. Front Immunol. 2018 Jun 27;9:1475. Skuljec J, Jirmo AC, Habener A, Talbot SR, Pul R, Grychtol R, Aydin M, Kleinschnitz C, Happle C, Hansen G. Absence of Regulatory T Cells Causes Phenotypic and Functional Switch in Murine Peritoneal Macrophages. Front. Immunol., 31 October 2018, doi.org/10.3389/fimmu.2018.02458 Stüve P, Minarrieta L, Erdmann H, Arnold-Schrauf C, Swallow M, Guderian M, Krull F, Hölscher A, Ghorbani P, Behrends J, Abraham WR, Hölscher C, Sparwasser TD, Berod L. De Novo Fatty Acid Synthesis During Mycobacterial Infection Is a Prerequisite for the Function of Highly Proliferative T Cells, But Not for Dendritic Cells or Macrophages. Front Immunol. 2018 Apr 5;9:495. doi: 10.3389/fimmu.2018.00495. eCollection 2018. PubMed PMID: 29675017; PubMed Central PMCID: PMC5895737. Theobald SJ, Khailaie S, Meyer-Hermann M, Volk V, Olbrich H, Danisch S, Gerasch L, Schneider A, Sinzger C, Schaudien D, Lienenklaus S, Riese P, Guzman CA, Figueiredo C, von Kaisenberg C, Spineli LM, Glaesener S, Meyer-Bahlburg A, Ganser A, Schmitt M, Mach M, Messerle M, Stripecke R. Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34(+) Cells. Front Immunol. 2018 Nov 22;9:2734. Yu J, Duong VHH, Westphal K, Westphal A, Suwandi A, Grassl GA, Brand K, Chan AC, Föger N, Lee KH. Surface receptor Toso controls B cell-mediated regulation of T cell immunity. J Clin Invest. 2018 May 1;128(5):1820-1836. doi: 10.1172/JCI97280. Epub 2018 Apr 3. PMID: 29461978 Free PMC article. 2017 Ackermann M, Kuhn A, Kunkiel J, Merkert S, Martin U, Moritz T, Lachmann N. Ex vivo Generation of Genetically Modified Macrophages from Human Induced Pluripotent Stem Cells. Transfus Med Hemother. 2017 Jun;44(3):135-142. Adams FF, Heckl D, Hoffmann T, Talbot SR, Kloos A, Thol F, Heuser M, Zuber J, Schambach A, Schwarzer A. An optimized lentiviral vector system for conditional RNAi and efficient cloning of microRNA embedded short hairpin RNA libraries. Biomaterials. 2017 Sep;139:102-115. doi: 10.1016/j.biomaterials.2017.05.032. Budida R, Stankov MV, Döhner K, Buch A, Panayotova-Dimitrova D, Tappe KA, Pohlmann A, Sodeik B, Behrens GMN. Herpes simplex virus 1 interferes with autophagy of murine dendritic cells and impairs their ability to stimulate CD8(+) T lymphocytes. Eur J Immunol. 2017 Oct;47(10):1819-1834. Diekmann U, Davenport C, Kresse J, Naujok O. Purification of Definitive Endoderm Generated from Pluripotent Stem Cells by Magnetic Cell Sorting. Curr Protoc Stem Cell Biol. 2017 Feb 2;40:1D.9.1-1D.9.17. Fraccarollo D, Galuppo P, Bauersachs J. Modeling Cardiac Fibrosis in Mice: (Myo)Fibroblast Phenotype After Ischemia. Methods Mol Biol. 2017;1627:123-137. doi: 10.1007/978-1-4939-7113-8_9. PubMed PMID: 28836199. Galuppo P, Vettorazzi S, Hövelmann J, Scholz CJ, Tuckermann JP, Bauersachs J, Fraccarollo D. The glucocorticoid receptor in monocyte-derived macrophages is critical for cardiac infarct repair and remodeling. FASEB J. 2017 Nov;31(11):5122-5132. doi: 10.1096/fj.201700317R. Epub 2017 Aug 2. Geis FK, Galla M, Hoffmann D, Kuehle J, Zychlinski D, Maetzig T, Schott JW, Schwarzer A, Goffinet C, Goff SP, Schambach A. Potent and reversible lentiviral vector restriction in murine induced pluripotent stem cells. Retrovirology. 2017 May 31;14(1):34. Getzin T, Krishnasamy K, Gamrekelashvili J, Kapanadze T, Limbourg A, Häger C, Napp LC, Bauersachs J, Haller H, Limbourg FP. The chemokine receptor CX(3)CR1 coordinates monocyte recruitment and endothelial regeneration after arterial injury. EMBO Mol Med. 2017 Dec 11. pii: e201607502. doi: 10.15252/emmm.201707502. Habener A, Behrendt AK, Skuljec J, Jirmo AC, Meyer-Bahlburg A, Hansen G. B cell subsets are modulated during allergic airway inflammation but are not required for the development of respiratory tolerance in a murine model. Eur J Immunol. 2017 Mar;47(3):552-562. doi: 10.1002/eji.201646518. Epub 2017 Jan 17. PMID: 27995616 Free article. Hetzel M, Mucci A, Blank P, Nguyen AHH, Schiller J, Halle O, Kühnel MP, Billig S, Meineke R, Brand D, Herder V, Baumgärtner W, Bange FC, Goethe R, Jonigk D, Förster R, Gentner B, Casanova JL, Bustamante J, Schambach A, Kalinke U, Lachmann N. Hematopoietic stem cell gene therapy for IFNγR1 deficiency protects mice from mycobacterial infections. Blood. 2017 Dec 12. pii: blood-2017-10-812859. doi: 10.1182/blood-2017-10-812859. [Epub ahead of print] Hetzel M, Suzuki T, Hashtchin AR, Arumugam P, Carey B, Schwabbauer M, Kuhn A, Meyer J, Schambach A, Van Der Loo J, Moritz T, Trapnell BC, Lachmann N. Function and Safety of Lentivirus-Mediated Gene Transfer for CSF2RA-Deficiency. Hum Gene Ther Methods. 2017 Dec;28(6):318-329. Lino CNR, Barros-Martins J, Oberdörfer L, Walzer T, Prinz I. Eomes expression reports the progressive differentiation of IFN-γ-producing Th1-like γδ T cells. Eur J Immunol. 2017 Jun;47(6):970-981. Nikolovska K, Spillmann D, Haier J, Ladányi A, Stock C, Seidler DG. Melanoma Cell Adhesion and Migration Is Modulated by the Uronyl 2-O Sulfotransferase. PLoS One. 2017 Jan 20;12(1):e0170054. doi: 10.1371/journal.pone.0170054. PubMed PMID: 28107390; PubMed Central PMCID: PMC5249195. Pittermann E, Lachmann N, MacLean G, Emmrich S, Ackermann M, Göhring G, Schlegelberger B, Welte K, Schambach A, Heckl D, Orkin SH, Cantz T, Klusmann JH. Gene correction of HAX1 reversed Kostmann disease phenotype in patient-specific induced pluripotent stem cells. Blood Adv. 2017 Jun 2;1(14):903-914. doi: 10.1182/bloodadvances.2016003798. Ravens S, Schultze-Florey C, Raha S, Sandrock I, Drenker M, Oberdörfer L, Reinhardt A, Ravens I, Beck M, Geffers R, von Kaisenberg C, Heuser M, Thol F, Ganser A, Förster R, Koenecke C, Prinz I. Human γδ T cells are quickly reconstituted after stem-cell transplantation and show adaptive clonal expansion in response to viral infection. Nat Immunol. 2017 Apr;18(4):393-401 Reboll MR, Korf-Klingebiel M, Klede S, Polten F, Brinkmann E, Reimann I, Schönfeld HJ, Bobadilla M, Faix J, Kensah G, Gruh I, Klintschar M, Gaestel M, Niessen HW, Pich A, Bauersachs J, Gogos JA, Wang Y, Wollert KC. EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction. Circulation. 2017 Nov 7;136(19):1809-1823. Reimer J, Knöß S, Labuhn M, Charpentier EM, Göhring G, Schlegelberger B, Klusmann JH, Heckl D. CRISPR-Cas9-induced t(11;19)/MLL-ENL translocations initiate leukemia in human hematopoietic progenitor cells in vivo. Haematologica. 2017 Sep;102(9):1558-1566. Schrimpf C, Wrede C, Glage S, Hegermann J, Backhaus S, Blasczyk R, Heuft HG, Müller T. Differentiation of induced pluripotent stem cell-derived neutrophil granulocytes from common marmoset monkey (Callithrix jacchus). Transfusion. 2017 Jan;57(1):60-69. Schwarzer A, Emmrich S, Schmidt F, Beck D, Ng M, Reimer C, Adams FF, Grasedieck S, Witte D, Käbler S, Wong JWH, Shah A, Huang Y, Jammal R, Maroz A, Jongen-Lavrencic M, Schambach A, Kuchenbauer F, Pimanda JE, Reinhardt D, Heckl D, Klusmann JH. The non-coding RNA landscape of human hematopoiesis and leukemia. Nat Commun. 2017 Aug 9;8(1):218. Sgodda M, Dai Z, Zweigerdt R, Sharma AD, Ott M, Cantz T. A Scalable Approach for the Generation of Human Pluripotent Stem Cell-Derived Hepatic Organoids with Sensitive Hepatotoxicity Features. Stem Cells Dev. 2017 Oct 15;26(20):1490-1504. Thol F, Klesse S, Köhler L, Gabdoulline R, Kloos A, Liebich A, Wichmann M, Chaturvedi A, Fabisch J, Gaidzik VI, Paschka P, Bullinger L, Bug G, Serve H, Göhring G, Schlegelberger B, Lübbert M, Kirchner H, Wattad M, Kraemer D, Hertenstein B, Heil G, Fiedler W, Krauter J, Schlenk RF, Döhner K, Döhner H, Ganser A, Heuser M. Acute myeloid leukemia derived from lympho-myeloid clonal hematopoiesis. Leukemia. 2017, 31(6):1286-1295 Westphal A, Cheng W, Yu J, Grassl G, Krautkrämer M, Holst O, Föger N, Lee KH. Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor-mediated inflammatory responses. J Exp Med. 2017 Jan;214(1):227-244. doi: 10.1084/jem.20141461. 2016 Abbey M, Hakim C, Anand R, Lafera J, Schambach A, Kispert A, Taft MH, Kaever V, Kotlyarov A, Gaestel M, Menon MB. GTPase domain driven dimerization of SEPT7 is dispensable for the critical role of septins in fibroblast cytokinesis. Sci Rep. 2016 Jan 28;6:20007. Chaturvedi A, Araujo Cruz MM, Jyotsana N, Sharma A, Goparaju R, Schwarzer A, Görlich K, Schottmann R, Struys EA, Jansen EE, Rohde C, Müller-Tidow C, Geffers R, Göhring G, Ganser A, Thol F, Heuser M. Enantiomer-specific and paracrine leukemogenicity of mutant IDH metabolite 2-hydroxyglutarate. Leukemia. 2016 Aug;30(8):1708-15. Davenport C, Diekmann U, Budde I, Detering N, Naujok O. Anterior-Posterior Patterning of Definitive Endoderm Generated from Human Embryonic Stem Cells Depends on the Differential Signaling of Retinoic Acid, Wnt-, and BMP-Signaling. Stem Cells. 2016 Jun 14. doi: 10.1002/stem.2428. [Epub ahead of print] PubMed PMID: 27299363. Dudek M, Puttur F, Arnold-Schrauf C, Kühl AA, Holzmann B, Henriques-Normark B, Berod L, Sparwasser T. Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection. Mucosal Immunol. 2016 Sep;9(5):1288-302. Eggenschwiler R, Moslem M, Fráguas MS, Galla M, Papp O, Naujock M, Fonfara I, Gensch I, Wähner A, Beh-Pajooh A, Mussolino C, Tauscher M, Steinemann D, Wegner F, Petri S, Schambach A, Charpentier E, Cathomen T, Cantz T. Improved bi-allelic modification of a transcriptionally silent locus in patient-derived iPSC by Cas9 nickase. Sci Rep. 2016 Dec 2;6:38198. Gamrekelashvili J, Giagnorio R, Jussofie J, Soehnlein O, Duchene J, Briseño CG, Ramasamy SK, Krishnasamy K, Limbourg A, Kapanadze T, Ishifune C, Hinkel R, Radtke F, Strobl LJ, Zimber-Strobl U, Napp LC, Bauersachs J, Haller H, Yasutomo K, Kupatt C, Murphy KM, Adams RH, Weber C, Limbourg FP. Regulation of monocyte cell fate by blood vessels mediated by Notch signalling. Nat Commun. 2016 Aug 31;7:12597. Georgiev H, Ravens I, Benarafa C, Förster R, Bernhardt G. Distinct gene expression patterns correlate with developmental and functional traits of iNKT subsets. Nat Commun. 2016 Oct 10;7:13116. Georgiev H, Ravens I, Shibuya A, Förster R, Bernhardt G. CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation. Eur J Immunol. 2016 Apr;46(4):993-1003. Gupta SK, Itagaki R, Zheng X, Batkai S, Thum S, Ahmad F, Van Aelst LN, Sharma A, Piccoli MT, Weinberger F, Fiedler J, Heuser M, Heymans S, Falk CS, Förster R, Schrepfer S, Thum T. miR-21 promotes fibrosis in an acute cardiac allograft transplantation model. Cardiovasc Res. 2016 May 15;110(2):215-26. Habener A, Behrendt AK, Skuljec J, Jirmo AC, Meyer-Bahlburg A, Hansen G. B cell subsets are modulated during allergic airway inflammation but are not required for the development of respiratory tolerance in a murine model. Eur J Immunol. 2016 Dec 20 Halle S, Keyser KA, Stahl FR, Busche A, Marquardt A, Zheng X, Galla M, Heissmeyer V, Heller K, Boelter J, Wagner K, Bischoff Y, Martens R, Braun A, Werth K, Uvarovskii A, Kempf H, Meyer-Hermann M, Arens R, Kremer M, Sutter G, Messerle M, Förster R. In Vivo Killing Capacity of Cytotoxic T Cells Is Limited and Involves Dynamic Interactions and T Cell Cooperativity. Immunity. 2016 Feb 16;44(2):233-45. Hübner J, Hoseini SS, Suerth JD, Hoffmann D, Maluski M, Herbst J, Maul H, Ghosh A, Eiz-Vesper B, Yuan Q, Ott M, Heuser M, Schambach A, Sauer MG. Generation of Genetically Engineered Precursor T-Cells From Human Umbilical Cord Blood Using an Optimized Alpharetroviral Vector Platform. Mol Ther. 2016 Aug;24(7):1216-26. Jirmo AC, Daluege K, Happle C, Albrecht M, Dittrich AM, Busse M, Habener A, Skuljec J, Hansen G. IL-27 Is Essential for Suppression of Experimental Allergic Asthma by the TLR7/8 Agonist R848 (Resiquimod). J Immunol. 2016 Dec 1;197(11):4219-4227. Klemann C, Schröder A, Dreier A, Möhn N, Dippel S, Winterberg T, Wilde A, Yu Y, Thorenz A, Gueler F, Jörns A, Tolosa E, Leonhardt J, Haas JD, Prinz I, Vieten G, Petersen C, Kuebler JF. Interleukin 17, Produced by γδ T Cells, Contributes to Hepatic Inflammation in a Mouse Model of Biliary Atresia and Is Increased in Livers of Patients. Gastroenterology. 2016 Jan;150(1):229-241.e5. Kohli K, Janssen A, Förster R. Plasmacytoid dendritic cells induce tolerance predominantly by cargoing antigen to lymph nodes. Eur J Immunol. 2016 Nov;46(11):2659-2668 Labenski V, Suerth JD, Barczak E, Heckl D, Levy C, Bernadin O, Charpentier E, Williams DA, Fehse B, Verhoeyen E, Schambach A. Alpharetroviral self-inactivating vectors produced by a superinfection-resistant stable packaging cell line allow genetic modification of primary human T lymphocytes. Biomaterials. 2016 Aug;97:97-109. Lee CW, Wohlan K, Dallmann I, Förster R, Ganser A, Krueger A, Scherr M, Eder M, Koenecke C. miR-181a Expression in Donor T Cells Modulates Graft-versus-Host Disease after Allogeneic Bone Marrow Transplantation. J Immunol. 2016 May 1;196(9):3927-34. Mahapatra S, Albrecht M, Baru AM, Sparwasser T, Herrick C, Dittrich AM. Superior Suppressive Capacity of Skin Tregs Compared with Lung Tregs in a Model of Epicutaneous Priming. J Invest Dermatol. 2015 Oct;135(10):2418-26. Manukjan G, Ripperger T, Venturini L, Stadler M, Göhring G, Schambach A, Schlegelberger B, Steinemann D. GABP is necessary for stem/progenitor cell maintenance and myeloid differentiation in human hematopoiesis and chronic myeloid leukemia. Stem Cell Res. 2016 May;16(3):677-81. Mucci A, Kunkiel J, Suzuki T, Brennig S, Glage S, Kühnel MP, Ackermann M, Happle C, Kuhn A, Schambach A, Trapnell BC, Hansen G, Moritz T, Lachmann N. Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb Deficiency. Stem Cell Reports. 2016 Aug 9;7(2):292-305. Noyan F, Zimmermann K, Hardtke-Wolenski M, Knoefel A, Schulde E, Geffers R, Hust M, Huehn J, Galla M, Morgan M, Jokuszies A, Manns MP, Jaeckel E. Prevention of allograft rejection by use of regulatory T cells with a MHC-specific chimeric antigen receptor. Am J Transplant. 2016 Dec 20. doi: 10.1111/ajt.14175. [Epub ahead of print] Pfaender S, Grabski E, Detje CN, Riebesehl N, Lienenklaus S, Steinmann E, Kalinke U, Pietschmann T. Hepatitis C Virus Stimulates Murine CD8α-Like Dendritic Cells to Produce Type I Interferon in a TRIF-Dependent Manner. PLoS Pathog. 2016 Jul;12(7):e1005736. Puttur F, Francozo M, Solmaz G, Bueno C, Lindenberg M, Gohmert M, Swallow M, Tufa D, Jacobs R, Lienenklaus S, Kühl AA, Borkner L, Cicin-Sain L, Holzmann B, Wagner H, Berod L, Sparwasser T. Conventional Dendritic Cells Confer Protection against Mouse Cytomegalovirus Infection via TLR9 and MyD88 Signaling. Cell Rep. 2016 Oct 18;17(4):1113-1127. Roesner LM, Heratizadeh A, Wieschowski S, Mittermann I, Valenta R, Eiz-Vesper B, Hennig C, Hansen G, Falk CS, Werfel T. α-NAC-Specific Autoreactive CD8+ T Cells in Atopic Dermatitis Are of an Effector Memory Type and Secrete IL-4 and IFN-γ. J Immunol. 2016 Apr 15;196(8):3245-52. Ronkina N, Lafera J, Kotlyarov A, Gaestel M. Stress-dependent phosphorylation of myocardin-related transcription factor A (MRTF-A) by the p38(MAPK)/MK2 axis. Sci Rep. 2016 Aug 5;6:31219. Roth A, Glaesener S, Schütz K, Meyer-Bahlburg A. Reduced Number of Transitional and Naive B Cells in Addition to Decreased BAFF Levels in Response to the T Cell Independent Immunogen Pneumovax®23. PLoS One. 2016 Mar 31;11(3):e0152215. Selich A, Daudert J, Hass R, Philipp F, von Kaisenberg C, Paul G, Cornils K, Fehse B, Rittinghausen S, Schambach A, Rothe M. Massive Clonal Selection and Transiently Contributing Clones During Expansion of Mesenchymal Stem Cell Cultures Revealed by Lentiviral RGB-Barcode Technology. Stem Cells Transl Med. 2016 May;5(5):591-601. Siemeni T, Knöfel AK, Madrahimov N, Sommer W, Avsar M, Salman J, Ius F, Frank N, Büchler G, Jonigk D, Jansson K, Maus U, Tudorache I, Falk CS, Haverich A, Warnecke G. In Vivo Development of Transplant Arteriosclerosis in Humanized Mice Reflects Alloantigen Recognition and Peripheral Treg Phenotype of Lung Transplant Recipients. Am J Transplant. 2016 Nov;16(11):3150-3162. Song G, Pacher M, Balakrishnan A, Yuan Q, Tsay HC, Yang D, Reetz J, Brandes S, Dai Z, Pützer BM, Araúzo-Bravo MJ, Steinemann D, Luedde T, Schwabe RF, Manns MP, Schöler HR, Schambach A, Cantz T, Ott M, Sharma AD. Direct Reprogramming of Hepatic Myofibroblasts into Hepatocytes In Vivo Attenuates Liver Fibrosis. Cell Stem Cell. 2016 Jun 2;18(6):797-808. Stahlhut M, Ha TC, Morgan M, Schambach A, Kustikova OS. Comparison of tetracycline-regulated promoters in lentiviral-based vectors in murine transplantation studies. Curr Gene Ther. 2016 Oct 13. [Epub ahead of print] Thiesler CT, Cajic S, Hoffmann D, Thiel C, van Diepen L, Hennig R, Sgodda M, Weiβmann R, Reichl U, Steinemann D, Diekmann U, Huber NM, Oberbeck A, Cantz T, Kuss AW, Körner C, Schambach A, Rapp E, Buettner FF. Glycomic Characterization of Induced Pluripotent Stem Cells Derived from a Patient Suffering from Phosphomannomutase 2 Congenital Disorder of Glycosylation (PMM2-CDG). Mol Cell Proteomics. 2016 Apr;15(4):1435-52. Tiedje C, Diaz-Muñoz MD, Trulley P, Ahlfors H, Laaß K, Blackshear PJ, Turner M, Gaestel M. The RNA-binding protein TTP is a global post-transcriptional regulator of feedback control in inflammation. Nucleic Acids Res. 2016 Sep 6;44(15):7418-40. Tufa DM, Ahmad F, Chatterjee D, Ahrenstorf G, Schmidt RE, Jacobs R. IL-1β limits the extent of human 6-sulfo LacNAc dendritic cell (slanDC)-mediated NK cell activation and regulates CD95-induced apoptosis. Cell Mol Immunol. 2016 Apr 18. doi: 10.1038/cmi.2016.17. [Epub ahead of print] Tufa DM, Ahmad F, Chatterjee D, Ahrenstorf G, Schmidt RE, Jacobs R. Brief Report: HIV-1 Infection Results in Increased Frequency of Active and Inflammatory SlanDCs that Produce High Level of IL-1β. J Acquir Immune Defic Syndr. 2016 Sep 1;73(1):34-8. Westphal A, Cheng W, Yu J, Grassl G, Krautkrämer M, Holst O, Föger N, Lee KH. Lysosomal trafficking regulator Lyst links membrane trafficking to toll-like receptor-mediated inflammatory responses. J Exp Med. 2016 Nov 23, [Epub ahead of print] Zheng X, Halle S, Yu K, Mishra P, Scherr M, Pietzsch S, Willenzon S, Janssen A, Boelter J, Hilfiker-Kleiner D, Eder M, Förster R. Cardiomyocytes display low mitochondrial priming and are highly resistant toward cytotoxic T-cell killing. Eur J Immunol. 2016 Jun;46(6):1415-26. 2015 Ballmaier M, Holter W, Germeshausen M. Flow cytometric detection of MPL (CD110) as a diagnostic tool for differentiation of congenital thrombocytopenias. Haematologica. 100:e341-4. Brennig S, Lachmann N, Buchegger T, Hetzel M, Schambach A, Moritz T (2015) Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1). J Exp Clin Cancer Res. 34:148 Buettner M, Dittrich-Breiholz O, Falk CS, Lochner M, Smoczek A, Menzel F, Bornemann M, Bode U. (2015) Stromal cells as trend-setters for cells migrating into the lymph node. Mucosal Immunol. 8:640-9 Daenthanasanmak A, Salguero G, Sundarasetty BS, Waskow C, Cosgun KN, Guzman CA, Riese P, Gerasch L, Schneider A, Ingendoh A, Messerle M, Gabaev I, Woelk B, Ruggiero E, Schmidt M, von Kalle C, Figueiredo C, Eiz-Vesper B, von Kaisenberg C, Ganser A, Stripecke R (2015) Engineered dendritic cells from cord blood and adult blood accelerate effector T cell immune reconstitution against HCMV. Mol Ther Methods Clin Dev. 1:14060. Dudek M, Puttur F, Arnold-Schrauf C, Kühl AA, Holzmann B, Henriques-Normark B, Berod L, Sparwasser T. (2015) Lung epithelium and myeloid cells cooperate to clear acute pneumococcal infection. Mucosal Immunol. 2015 Dec 2. [Epub ahead of print] Dong L, Nordlohne J, Ge S, Hertel B, Melk A, Rong S, Haller H, von Vietinghoff S. (2015) T Cell CX3CR1 Mediates Excess Atherosclerotic Inflammation in Renal Impairment. J Am Soc Nephrol. 2015 Oct 8. [Epub ahead of print] Emmrich S, Engeland F, El-Khatib M, Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink MM, Klusmann JH. (2015) miR-139-5p controls translation in myeloid leukemia through EIF4G2. Oncogene. 2015 Jul 13. [Epub ahead of print] Garrels W, Mukherjee A, Holler S, Cleve N, Talluri TR, Barg-Kues B, Diederich M, Köhler P, Petersen B, Lucas-Hahn A, Niemann H, Izsvák Z, Ivics Z, Kues WA. (2015) Identification and re-addressing of a transcriptionally permissive locus in the porcine genome. Transgenic Res. 2015 Oct 29. [Epub ahead of print] Georgiev H, Ravens I, Shibuya A, Förster R, Bernhardt G. (2015) CD155/CD226-interaction impacts on the generation of innate CD8(+) thymocytes by regulating iNKT-cell differentiation. Eur J Immunol. 2015 Dec 22. [Epub ahead of print] Hardtke-Wolenski M, Taubert R, Noyan F, Sievers M, Dywicki J, Schlue J, Falk CS, Ardesjö Lundgren B, Scott HS, Pich A, Anderson MS, Manns MP, Jaeckel E. (2015) Autoimmune hepatitis in a murine autoimmune polyendocrine syndrome type 1 model is directed against multiple autoantigens. Hepatology. 2015 Apr;61(4):1295-305. Hoseini SS, Hapke M, Herbst J, Wedekind D, Baumann R, Heinz N, Schiedlmeier B, Vignali DA, van den Brink MR, Schambach A, Blazar BR, Sauer MG (2015) Inducible T-cell receptor expression in precursor T cells for leukemia control. Leukemia. 29:1530-42. Kashani E, Föhse L, Raha S, Sandrock I, Oberdörfer L, Koenecke C, Suerbaum S, Weiss S, Prinz I (2015) A clonotypic Vγ4Jγ1/Vδ5Dδ2Jδ1 innate γδ T-cell populationrestricted to the CCR6(+)CD27(-) subset. Nat Commun. 6:6477. Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T, Niessen HW, Mizrahi J, Schönfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC (2015) Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction. Nat Med. 21:140-9 Lachmann N, Ackermann M, Frenzel E, Liebhaber S, Brennig S, Happle C, Hoffmann D, Klimenkova O, Lüttge D, Buchegger T, Kühnel MP, Schambach A, Janciauskiene S, Figueiredo C, Hansen G, Skokowa J, Moritz T (2015) Large-scale hematopoietic differentiation of human induced pluripotent stem cells provides granulocytes or macrophages for cell replacement therapies. Stem Cell Reports. 4:282-96. Lachmann N, Brennig S, Hillje R, Schermeier H, Phaltane R, Dahlmann J, Gruh I, Heinz N, Schiedlmeier B, Baum C, Moritz T (2015) Tightly regulated 'all-in-one' lentiviral vectors for protection of human hematopoietic cells from anticancer chemotherapy. Gene Ther. 22:883-92. Lachmann N, Czarnecki K, Brennig S, Phaltane R, Heise M, Heinz N, Kempf H, Dilloo D, Kaever V, Schambach A, Heuser M, Moritz T (2015) Deoxycytidine-kinase knockdown as a novel myeloprotective strategy in the context of fludarabine, cytarabine or cladribine therapy. Leukemia. 29:2266-9 Łyszkiewicz M, Ziętara N, Föhse L, Puchałka J, Diestelhorst J, Witzlau K, Prinz I, Schambach A, Krueger A. (2015) Limited niche availability suppresses murine intrathymic dendritic-cell development from noncommitted progenitors. Blood. 125:457-64 Manukjan G, Ripperger T, Santer L, von Neuhoff N, Ganser A, Schambach A, Schlegelberger B, Steinemann D. (2015) Expression of the ETS transcription factor GABPα is positively correlated to the BCR-ABL1/ABL1 ratio in CML patients and affects imatinib sensitivity in vitro. Exp Hematol. 43:880-90. Müller C, Tufa DM, Chatterjee D, Mühlradt PF, Schmidt RE, Jacobs R (2015) The TLR-2/TLR-6 agonist macrophage-activating lipopeptide-2 augments human NK cell cytotoxicity when PGE2 production by monocytes is inhibited by a COX-2 blocker. Cancer Immunol Immunother. 64:1175-84 Pokoyski C, Lienen T, Rother S, Schock E, Plege-Fleck A, Geffers R, Schwinzer R. (2015) Overexpression of CD45RA isoforms in carriers of the C77G mutation leads to hyporeactivity of CD4(+)CD25(high)Foxp3(+) regulatory T cells. Genes Immun. 16:519-27. Regelin M, Blume J, Pommerencke J, Vakilzadeh R, Witzlau K, Łyszkiewicz M, Ziętara N, Saran N, Schambach A, Krueger A. (2015) Responsiveness of Developing T Cells to IL-7 Signals Is Sustained by miR-17∼92. J Immunol. 195:4832-40. Ripperger T, Manukjan G, Meyer J, Wolter S, Schambach A, Bohne J, Modlich U, Li Z, Skawran B, Schlegelberger B, Steinemann D. (2015) The heteromeric transcription factor GABP activates the ITGAM/CD11b promoter and induces myeloid differentiation. Biochim Biophys Acta. 1849:1145-54 Sandrock, I., N. Zietara, M. Lyszkiewicz, L. Oberdorfer, K. Witzlau, A. Krueger, Prinz I. (2015) MicroRNA-181a/b-1 Is Not Required for Innate gammadelta NKT Effector Cell Development. PLoS One 10:e0145010. Schott JW, Jaeschke NM, Hoffmann D, Maetzig T, Ballmaier M, Godinho T, Cathomen T, Schambach A. Deciphering the impact of parameters influencing transgene expression kinetics after repeated cell transduction with integration-deficient retroviral vectors. Cytometry A. 87:405-18. Schwarzer A, Holtmann H, Brugman M, Meyer J, Schauerte C, Zuber J, Steinemann D, Schlegelberger B, Li Z, Baum C. Hyperactivation of mTORC1 and mTORC2 by multiple oncogenic events causes addiction to eIF4E-dependent mRNA translation in T-cell leukemia. Oncogene. 34:3593-604 Sharma A, Yun H, Jyotsana N, Chaturvedi A, Schwarzer A, Yung E, Lai CK, Kuchenbauer F, Argiropoulos B, Görlich K, Ganser A, Humphries RK, Heuser M. (2015) Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling. Leukemia. 29:157-68 Sogkas G, Vögtle T, Rau E, Gewecke B, Stegner D, Schmidt RE, Nieswandt B, Gessner JE (2015) Orai1 controls C5a-induced neutrophil recruitment in inflammation. Eur J Immunol. 45:2143-53 Sommer W, Knöfel AK, Madrahimov N, Avsar M, Jonigk D, Salman J, Dreckmann K, Jansson K, Salguero G, Maus UA, Welte T, Haverich A, Warnecke G. (2015) Allogeneic CD4+CD25high T cells regulate obliterative bronchiolitis of heterotopic bronchus allografts in both porcinized and humanized mouse models. Transplantation. 99:482-91. Stahlhut M, Schwarzer A, Eder M, Yang M, Li Z, Morgan M, Schambach A, Kustikova OS. (2015) Lentiviral vector system for coordinated constitutive and drug controlled tetracycline-regulated gene co-expression. Biomaterials. 63:189-201 Torow N, Dittrich-Breiholz O, Hornef MW (2015) Transcriptional profiling of intestinal CD4(+) T cells in the neonatal and adult mice. Genom Data. 5:371-4. Torow N, Yu K, Hassani K, Freitag J, Schulz O, Basic M, Brennecke A, Sparwasser T, Wagner N, Bleich A, Lochner M, Weiss S, Förster R, Pabst O, Hornef MW. (2015) Active suppression of intestinal CD4(+)TCRαβ(+) T-lymphocyte maturation during the postnatal period. Nat Commun. 6:7725. Velaga S, Ukena SN, Dringenberg U, Alter C, Pardo J, Kershaw O, Franzke A (2015) Granzyme A Is Required for Regulatory T-Cell Mediated Prevention of Gastrointestinal Graft-versus-Host Disease. PLoS One. 10:e0124927. Winterberg T, Vieten G, Meier T, Yu Y, Busse M, Hennig C, Hansen G, Jacobs R, Ure BM, Kuebler JF. Distinct phenotypic features of neonatal murine macrophages. Eur J Immunol. 45:214-24. Yang Y, Otte A, Hass R. (2015) Human mesenchymal stroma/stem cells exchange membrane proteins and alter functionality during interaction with different tumor cell lines. Stem Cells Dev. 24:1205-22. Zhang H, Goudeva L, Immenschuh S, Schambach A, Skokowa J, Eiz-Vesper B, Blasczyk R, Figueiredo C (2015) miR-155 is associated with the leukemogenic potential of the class IV granulocyte colony-stimulating factor receptor in CD34⁺ progenitor cells. Mol Med. 20:736-46. Zhang S, Bakshi RK, Suneetha PV, Fytili P, Antunes DA, Vieira GF, Jacobs R, Klade CS, Manns MP, Kraft AR, Wedemeyer H, Schlaphoff V, Cornberg M (2015) Frequency, Private Specificity, and Cross-Reactivity of Preexisting Hepatitis C Virus (HCV)-Specific CD8+ T Cells in HCV-Seronegative Individuals: Implications for Vaccine Responses. J Virol. 89:8304-17. Ziętara N, Łyszkiewicz M, Puchałka J, Witzlau K, Reinhardt A, Förster R, Pabst O, Prinz I, Krueger A. (2015) Multicongenic fate mapping quantification of dynamics of thymus colonization. J Exp Med. 212:1589-601

Publikationen For current publications of the Surgical Research Laboratory we also refer to PubMed . Selected publications from the Surgical Research Lab and the Department of General, Visceral and Transplant Surgery: 2025 Assfalg V, Stocker F, Hüser N, Hartmann D, Matevossian E, van Bruchem M, Vogelaar S, Renders L, Schmaderer C, Margreiter C, Deak A, Messner F, Kammer M, Ysebaert D, Jacobs-Tulleneers-Thevissen D, Michalski D, van Laecke S, Gillard P, Kahl A, Viebahn R, Riediger C, Jänigen B, Schmelzle M , von Samson-Himmelstjerna FA, Stippel D, Harth A, Nitschke M, Koliogiannis D, Pascher A, Hoyer J, Weinmann-Menke J, Schiffer M, Hinz S, Nadalin S, Lopau K, Huurman V, Arnol M, Miller G. Combined Pancreas-Kidney Transplantation After Rescue Allocation: The Eurotransplant Experience: A Retrospective Multicenter Outcome Analysis . Transplantation. 2025 Mar 10. doi: 10.1097/TP.0000000000005354. Epub ahead of print. PMID: 40059095. Wiemann BA, Beetz O, Weigle CA, Tessmer P, Störzer S, Kleine-Döpke D, Vondran FWR, Richter N, Schmelzle M, Oldhafer F. Early Allograft Dysfunction after liver transplantation- definition, incidence and relevance in a single-centre analysis. Langenbecks Arch Surg. 2025 Feb 19;410(1):76. doi: 10.1007/s00423-025-03633-8. PMID: 39969574; PMCID: PMC11839853. Wang R, Hu M, Lozzi I, Jin CZJ, Ma D, Splith K , Mengwasser J , Wolf V , Feldbrügge L , Tang P, Timmermann L, Hillebrandt KH, Kirchner M, Mertins P, Hilfenhaus G, Neumann CCM, Kammertoens T, Pratschke J, Malinka T, Sauer IM, Noessner E, Guo ZS, Felsenstein M. Cytokine-armed vaccinia virus promotes cytotoxicity toward pancreatic carcinoma cells via activation of human intermediary CD56dimCD16dim natural killer cells. Int J Cancer. 2025 Feb 1;156(3):638-651. doi: 10.1002/ijc.35209. Epub 2024 Oct 14. PMID: 39400317; PMCID: PMC11621990. Krendl FJ, Faria I, Singh J , Oberhuber R, Martins PN. Machine Perfusion Liver Preservation: Highlights From the International Liver Transplant Society 2024 . Artif Organs. 2025 Jan 31. doi: 10.1111/aor.14956. Epub ahead of print. PMID: 39888065. Schütte SL, Tiede A, Mauz JB, Rieland H, Kabelitz M, Iker R, Richter N , Meyer B, Heidrich B, Wedemeyer H, Maasoumy B, Tergast TL. Comparison of clinical outcomes in patients with refractory ascites treated with either TIPS, tunneled peritoneal catheter, or ascites pump. Hepatol Commun. 2025 Jan 16;9(2):e0620. doi: 10.1097/HC9.0000000000000620. PMID: 39813591; PMCID: PMC11737501. 2024 Santol J, Ammann M, Reese T, Oldhafer F , Dong Y, Schmelzle M , Oldhafer KJ, Hackl H, Gruenberger T, Starlinger P. Reply to: Comparison of the LiMAx test vs. the APRI+ALBI score - Incorrect comparison parameters lead to questionable results. Eur J Surg Oncol. 2024 Dec;50(12):108696. doi: 10.1016/j.ejso.2024.108696. Epub 2024 Sep 20. PMID: 39306501. Weigle CA, Wiemann BA, Tessmer P, Störzer S, Novikova V, Richter N, Klempnauer J , Pfister ED, Baumann U, Leiskau C, Vondran FWR, Oldhafer F, Beetz O. Perioperative Complications After Pediatric Liver Transplantation-A Retrospective Analysis of 421 Cases. Pediatr Transplant. 2024 Nov;28(7):e14872. doi: 10.1111/petr.14872. PMID: 39385715. Pape T, von Garrel T, Hunkemöller AM, Nalbant B, Vondran FWR , Richter N , Heidrich B, Schneider A, Taubert R, von Hahn T, Wedemeyer H, Seeliger B, Lenzen H, Stahl K. Percutaneous transhepatic biliary drainage in patients with cholestasis following liver transplantation. Abdom Radiol (NY). 2024 Nov 5. doi: 10.1007/s00261-024-04657-2. Epub ahead of print. PMID: 39500762. Lozzi I, Arnold A, Barone M, Johnson JC, Sinn BV, Eschrich J, Gebert P, Wang R, Hu M, Feldbrügge L , Schirmeier A, Reutzel-Selke A, Malinka T, Krenzien F, Schöning W, Modest DP, Pratschke J, Sauer IM, Felsenstein M. Clinical prognosticators and targets in the immune microenvironment of intrahepatic cholangiocarcinoma. Oncoimmunology. 2024 Oct 1;13(1):2406052. doi: 10.1080/2162402X.2024.2406052. PMID: 39359389; PMCID: PMC11445892. Doll J, Maurus K, Köhler F , Matthes N, Lock JF, Germer CT, Rosenwald A, Wiegering A. Molecular Profiling of Low-Grade Appendiceal Mucinous Neoplasms (LAMN) . Genes Chromosomes Cancer. 2024 Oct;63(10):e23270. doi: 10.1002/gcc.23270. PMID: 39400480. Ringe B . Achievements in Liver Surgery and Transplantation at the Hannover Medical School, Germany. Transplantation. 2024 Oct 1. doi: 10.1097/TP.0000000000005203. Epub ahead of print. PMID: 39350318. Zwirner U, Kleine-Döpke D, Wagner A, Störzer S, Gronau F, Beetz O , Richter N, Gwinner W , Kulik U, Schmelzle M, Schrem H. Prediction of Renal Graft Function 1 Year After Adult Deceased-Donor Kidney Transplantation Using Variables Available Prior to Transplantation. Ann Transplant. 2024 Oct 1;29:e944603. doi: 10.12659/AOT.944603. PMID: 39350474; PMCID: PMC11453122. Tessmer P, Weigle CA, Meyer A, Wiemann BA , Gwinner W, Einecke G , Klempnauer J, Vondran FWR, Richter N, Oldhafer F, Beetz O . Kidney re-transplantation in the ipsilateral iliac fossa: a surgeon's perspective on perioperative outcome. Clin Kidney J. 2024 Sep 2;17(9):sfae271. doi: 10.1093/ckj/sfae271. PMID: 39323730; PMCID: PMC11422716. Praktiknjo M, Pena Solano AS, Sadeghlar F, Welchowski T, Schmid M, Möhring C, Zhou T, Mahn R, Monin MB, Meyer C, Feldmann G, Brossart P, van Beekum C , Semaan A, Matthaei H, Manekeller S, Sprinkart AM, Nowak S, Luetkens J, Kalff JC, Strassburg CP, González-Carmona MA. The impact of lenvatinib on sarcopenia in patients with advanced unresectable hepatocellular carcinoma. Sci Rep. 2024 Sep 27;14(1):22146. doi: 10.1038/s41598-024-66766-8. PMID: 39333610; PMCID: PMC11437060. Hu J, Guo Y, Wang X, Yeow M, Wu AGR, Fuks D, Soubrane O, Dokmak S, Gruttadauria S, Zimmitti G, Ratti F, Kato Y, Scatton O, Herman P, Aghayan DL, Marino MV, Croner RS, Mazzaferro V, Chiow AKH, Sucandy I, Ivanecz A, Choi SH, Lee JH, Gastaca M, Vivarelli M, Giuliante F, Ruzzenente A, Yong CC, Yin M, Fondevila C, Efanov M, Morise Z, Di Benedetto F, Brustia R, Valle RD, Boggi U, Geller D, Belli A, Memeo R, Mejia A, Park JO, Rotellar F, Choi GH, Robles-Campos R, Hasegawa K, Swijnenburg RJ, Sutcliffe RP, Pratschke J, Lai ECH, Chong CCN, D'Hondt M, Monden K, Lopez-Ben S, Kingham TP, Schmelzle M , Hawksworth J, Peng Y, Ferrero A, Ettorre GM, Cherqui D, Liang X, Wakabayashi G, Troisi RI, Cillo U, Cheung TT, Sugimoto M, Sugioka A, Han HS, Long TCD, Hilal MA, Zhang W, Wei Y, Chen KH, Aldrighetti L, Edwin B, Liu R, Goh BKP; International robotic and laparoscopic liver resection study group investigators. Propensity Score-matched Analysis Comparing Robotic Versus Laparoscopic Minor Liver Resections of the Anterolateral Segments: an International Multi-center Study of 10,517 Cases. Ann Surg. 2024 Sep 5. doi: 10.1097/SLA.0000000000006523. Epub ahead of print. PMID: 39234677. Saleh M, Pascual F, Ghallab M, Wu AGR, Chin KM, Ratti F, Giglio MC, Garatti M, Nghia PP, Kato Y, Lim C, Herman P, Coelho FF, Schmelzle M , Pratschke J, Aghayan DL, Liu Q, Marino MV, Belli A, Chiow AKH, Sucandy I, Ivanecz A, Di Benedetto F, Choi SH, Lee JH, Park JO, Prieto M, Guzman Y, Fondevila C, Efanov M, Rotellar F, Choi GH, Robles-Campos R, Kadam P, Sutcliffe RP, Troisi RI, Tang CN, Chong CC, D'Hondt M, Dalla Valle B, Ruzzenente A, Kingham TP, Scatton O, Liu R, Mejia A, Mishima K, Wakabayashi G, Lopez-Ben S, Wang X, Ferrero A, Ettorre GM, Vivarelli M, Mazzaferro V, Giuliante F, Yong CC, Yin M, Monden K, Geller D, Chen KH, Sugioka A, Edwin B, Cheung TT, Long TCD, Abu Hilal M, Aldrighetti L, Soubrane O, Fuks D, Han HS, Cherqui D, Goh BKP; International Robotic and Laparoscopic Liver Resection Study Group Investigators. Factors Associated with and Impact of Open Conversion in Laparoscopic and Robotic Minor Liver Resections: An International Multicenter Study of 10,541 Patients. Ann Surg Oncol. 2024 Sep;31(9):5615-5630. doi: 10.1245/s10434-024-15498-0. Epub 2024 Jun 15. PMID: 38879668. Köhler F, Rau B . Gendermedizin bei peritonealen Erkrankungen [Gender medicine in peritoneal diseases] . Chirurgie (Heidelb). 2024 Sep;95(9):742-747. German. doi: 10.1007/s00104-024-02142-6. Epub 2024 Aug 1. PMID: 39090450. Linge H, Nevermann N, Schmelzle M, Quante M . Geschlechtsunterschiede in der hepatobiliären und Transplantationschirurgie [Sex differences in hepatobiliary and transplantation surgery] . Chirurgie (Heidelb). 2024 Sep;95(9):715-720. German. doi: 10.1007/s00104-024-02139-1. Epub 2024 Aug 1. PMID: 39090449. Ahmadzada B, Felgendreff P , Minshew AM, Amiot BP, Nyberg SL. Producing Human Livers From Human Stem Cells Via Blastocyst Complementation. Curr Opin Biomed Eng. 2024 Sep;31:100537. doi: 10.1016/j.cobme.2024.100537. Epub 2024 May 16. PMID: 38854436; PMCID: PMC11160964. Kamali C, Brunnbauer P, Kamali K, Saqr AA, Arnold A, Harman Kamali G, Babigian J, Keshi E, Mohr R, Felsenstein M, Moosburner S, Hillebrandt KH, Bartels J, Sauer IM, Tacke F, Schmelzle M , Pratschke J, Krenzien F. Extracellular NAD+ response to post-hepatectomy liver failure: bridging preclinical and clinical findings. Commun Biol. 2024 Aug 14;7(1):991. doi: 10.1038/s42003-024-06661-0. PMID: 39143151; PMCID: PMC11324947. Elfers K, Sehnert AS, Wagner A, Zwirner U, Linge H, Kulik U , Poehnert D, Winny M , Gundert B, Aselmann H, Mazzuoli-Weber G. Functional and Structural Investigation of Myenteric Neurons in the Human Colon. Gastro Hep Adv. 2024 Aug 24;4(1):100537. doi: 10.1016/j.gastha.2024.08.016. PMID: 39790245; PMCID: PMC11714724. Hertel N, Dastagir K, Schmelzle M , Feldbrügge L , Helms F, Vogt PM, Ruhparwar A, Popov AF. Omentoplasty for Cervical Lymphocele after Aortic Arch Replacement. J Clin Med. 2024 Aug 12;13(16):4737. doi: 10.3390/jcm13164737. PMID: 39200878; PMCID: PMC11355863. Holzner ML, Mazzaferro V, Busset MDD, Aldrighetti L, Ratti F, Hasegawa K, Arita J, Sapisochin G, Abreu P, Schoning W, Schmelzle M, Nevermann N , Pratschke J, Florman S, Halazun K, Schwartz ME, Tabrizian P. I s Repeat Resection for Recurrent Intrahepatic Cholangiocarcinoma Warranted? Outcomes of an International Analysis. Ann Surg Oncol. 2024 Jul;31(7):4397-4404. doi: 10.1245/s10434-024-14975-w. Epub 2024 Feb 9. PMID: 38334851. Muth V , Stobl F, Michelotto J, Gilles L, Kirwan JA, Eisenberger A, Marchand J, Roschke NN, Moosburner S, Pratschke J, Sauer IM, Raschzok N, Gassner JM. Quality Assessment by Bile Composition in Normothermic Machine Perfusion of Rat Livers. Tissue Eng Part A. 2024 Jul 3. doi: 10.1089/ten.TEA.2024.0048. Epub ahead of print. PMID: 38832856. Sijberden JP, Hoogteijling TJ, Aghayan D, Ratti F, Tan EK, Morrison-Jones V, Lanari J, Haentjens L, Wei K, Tzedakis S, Martinie J, Osei Bordom D, Zimmitti G, Crespo K, Magistri P, Russolillo N, Conci S, Görgec B, Benedetti Cacciaguerra A, D'Souza D, Zozaya G, Caula C, Geller D, Robles Campos R, Croner R, Rehman S, Jovine E, Efanov M, Alseidi A, Memeo R, Dagher I, Giuliante F, Sparrelid E, Ahmad J, Gallagher T, Schmelzle M , Swijnenburg RJ, Fretland ÅA, Cipriani F, Koh YX, White S, Lopez Ben S, Rotellar F, Serrano PE, Vivarelli M, Ruzzenente A, Ferrero A, Di Benedetto F, Besselink MG, Sucandy I, Sutcliffe RP, Vrochides D, Fuks D, Liu R, D'Hondt M, Cillo U, Primrose JN, Goh BKP, Aldrighetti LA, Edwin B, Abu Hilal M; International consortium on Minimally Invasive Liver Surgery (I-MILS). Robotic Versus Laparoscopic Liver Resection in Various Settings: An International Multicenter Propensity Score Matched Study of 10.075 Patients. Ann Surg. 2024 Jul 1;280(1):108-117. doi: 10.1097/SLA.0000000000006267. Epub 2024 Mar 14. PMID: 38482665; PMCID: PMC11161239. Felgendreff P , Hosseiniasl SM, Minshew A, Amiot BP, Wilken S, Ahmadzada B, Huebert RC, Sakrikar NJ, Engles NG, Halsten P, Mariakis K, Barry J, Riesgraf S, Fecteau C, Ross JJ, Nyberg SL. First Application of a Mixed Porcine-Human Repopulated Bioengineered Liver in a Preclinical Model of Post-Resection Liver Failure. Biomedicines. 2024 Jun 7;12(6):1272. doi: 10.3390/biomedicines12061272. PMID: 38927479; PMCID: PMC11201206. Krendl FJ, Cardini B, Laimer G, Singh J , Resch T, Oberhuber R, Schneeberger S. Normothermic Liver Machine Perfusion and Successful Transplantation of Split Liver Grafts: From Proof of Concept to Clinical Implementation. Transplantation. 2024 Jun 1;108(6):1410-1416. doi: 10.1097/TP.0000000000004997. Epub 2024 May 23. PMID: 38548703. Weigle CA, Beetz O, Wiemann BA, Tessmer P, Störzer S, Cammann S, Vondran FWR, Oldhafer F, Schmelzle M , Richter N . Resection of intrahepatic cholangiocarcinoma in octogenarians: a single-center analysis . Discov Oncol. 2024 Jun 12;15(1):224. doi: 10.1007/s12672-024-01065-2. PMID: 38865024; PMCID: PMC11169410. Li W, van der Doef HPJ, Wildhaber BE, Marra P, Bravi M, Pinelli D, Minetto J, Dip M, Sierre S, de Santibañes M, Ardiles V, Uno JW, Hardikar W, Bates S, Goh L, Aldrian D, Seisenbacher J, Vogel GF, Neto JS, Antunes da Fonseca E, Magalhães Costa C, Ferreira CT, Nader LS, Farina MA, Dajani KZ, Parente A, Bigam DL, Liang TB, Bai X, Zhang W, Gonsorčíková L, Froněk J, Bohuš Š, Franchi-Abella S, Gonzales E, Guérin F, Junge N, Baumann U, Richter N , Hartleif S, Sturm E, Rajakannu M, Palaniappan K, Rela M, Pawaria A, Rajakrishnan H, Surendran S, Kumar M, Agarwal S, Gupta S, Asthana S, Bandewar V, Raichurkar K, Spada M, Monti L, Alterio T, Yanagi Y, Uchida H, Komine R, Evans H, Carr-Boyd P, Duncan D, Stefanowicz M, Latka-Grot J, Kolesnik A, Broering DC, Raptis DA, Ann H Marquez K, Mali V, Aw M, Beretta M, Van der Schyff F, Quintero-Bernabeu J, Mercadal-Hally M, Larrarte K M, Andres AM, Hernandez-Oliveros F, Frauca E, Casswall T, Jorns C, Delle M, Gupte G, Sharif K, McGuirk S, Superina R, Caicedo JC, Jaramillo C, Bitterfeld L, Kastenberg Z, Shah AA, Domenick B, Acord MR, Mazariegos GV, Soltys K, DiNorcia J, Antala S, Florman SS, Buchholz BM, Herden U, Fischer L, Dierckx RAJO, Hartog H, Bokkers RPH. Incidence, management and outcomes in hepatic artery complications after paediatric liver transplantation: protocol of the retrospective, international, multicentre HEPATIC Registry. BMJ Open. 2024 Jun 12;14(6):e081933. doi: 10.1136/bmjopen-2023-081933. PMID: 38866577; PMCID: PMC11177692. Assfalg V, Miller G, Stocker F, Hüser N, Hartmann D, Heemann U, Tieken I, Zanen W, Vogelaar S, Rosenkranz AR, Schneeberger S, Függer R, Berlakovich G, Ysebaert DR, Jacobs-Tulleneers-Thevissen D, Mikhalski D, van Laecke S, Kuypers D, Mühlfeld AS, Viebahn R, Pratschke J, Melchior S, Hauser IA, Jänigen B, Weimer R, Richter N , Foller S, Schulte K, Kurschat C, Harth A, Moench C, Rademacher S, Nitschke M, Krämer BK, Renders L, Koliogiannis D, Pascher A, Hoyer J, Weinmann-Menke J, Schiffer M, Banas B, Hakenberg O, Schwenger V, Nadalin S, Lopau K, Piros L, Nemes B, Szakaly P, Bouts A, Bemelman FJ, Sanders JS, de Vries APJ, Christiaans MHL, Hilbrands L, van Zuilen AD, Arnol M, Stippel D, Wahba R. Rescue Allocation Modes in Eurotransplant Kidney Transplantation: Recipient Oriented Extended Allocation Versus Competitive Rescue Allocation-A Retrospective Multicenter Outcome Analysis. Transplantation. 2024 May 1;108(5):1200-1211. doi: 10.1097/TP.0000000000004878. Epub 2023 Dec 11. PMID: 38073036. Ashraf MI*, Mengwasser J* , Reutzel-Selke A, Polenz D, Führer K, Lippert S, Tang P, Michaelis E, Catar R, Pratschke J, Witzel C, Sauer IM, Tullius SG, Kern B. Depletion of donor dendritic cells ameliorates immunogenicity of both skin and hind limb transplants. Front Immunol. 2024 May 10;15:1395945. doi: 10.3389/fimmu.2024.1395945. PMID: 38799435; PMCID: PMC11116604. Santol J, Ammann M, Reese T, Kern AE, Laferl V, Oldhafer F , Dong Y, Rumpf B, Vali M, Wiemann B , Ortmayr G, Brunner SE, Probst J, Aiad M, Jankoschek AS, Gramberger M, Tschoegl MM, Salem M, Surci N, Thonhauser R, Mazari V, Hoblaj T, Thalhammer S, Schmelzle M , Oldhafer KJ, Gruenberger T, Starlinger P. Comparison of the LiMAx test vs. the APRI+ALBI score for clinical utility in preoperative risk assessment in patients undergoing liver surgery - A European multicenter study. Eur J Surg Oncol. 2024 Apr;50(4):108048. doi: 10.1016/j.ejso.2024.108048. Epub 2024 Feb 21. PMID: 38471374. Knitter S, Raschzok N, Hillebrandt KH, Benzing C, Moosburner S, Nevermann N , Haber P, Gül-Klein S, Fehrenbach U, Lurje G, Schöning W, Fangmann J, Glanemann M, Kalff JC, Mehrabi A, Michalski C, Reißfelder C, Schmeding M, Schnitzbauer AA, Stavrou GA, Werner J, Pratschke J, Krenzien F; members of StuDoQ|Liver of Deutsche Gesellschaft für Allgemein-und Viszeralchirurgie/StuDoQ. Short-term postoperative outcomes of lymphadenectomy for cholangiocarcinoma, hepatocellular carcinoma and colorectal liver metastases in the modern era of liver surgery: Insights from the StuDoQ|Liver registry. Eur J Surg Oncol. 2024 Apr;50(4):108010. doi: 10.1016/j.ejso.2024.108010. Epub 2024 Feb 8. PMID: 38394988. Zwirner S, Abu Rmilah AA, Klotz S, Pfaffenroth B, Kloevekorn P, Moschopoulou AA, Schuette S, Haag M, Selig R, Li K, Zhou W, Nelson E, Poso A, Chen H, Amiot B, Jia Y, Minshew A, Michalak G, Cui W, Rist E, Longerich T, Jung B, Felgendreff P , Trompak O, Premsrirut PK, Gries K, Muerdter TE, Heinkele G, Wuestefeld T, Shapiro D, Weissbach M, Koenigsrainer A, Sipos B, Ab E, Zacarias MO, Theisgen S, Gruenheit N, Biskup S, Schwab M, Albrecht W, Laufer S, Nyberg S, Zender L. First-in-class MKK4 inhibitors enhance liver regeneration and prevent liver failure. Cell. 2024 Mar 28;187(7):1666-1684.e26. doi: 10.1016/j.cell.2024.02.023. Epub 2024 Mar 14. PMID: 38490194; PMCID: PMC11011246. Felgendreff P , Hosseiniasl SM, Felgendreff L, Amiot BP, Minshew A, Ahmadzada B, Qu Z, Wilken S, Arribas Gomez I, Nyberg SL, Cook CN. Comprehensive analysis of brain injury parameters in a preclinical porcine model of acute liver failure. Front Med (Lausanne). 2024 Mar 28;11:1363979. doi: 10.3389/fmed.2024.1363979. PMID: 38606159; PMCID: PMC11007081. Gronewold M, Grote I, Bartels S, Christgen H, Kandt LD, Brito MJ, Cserni G, Daemmrich ME, Fogt F, Helmke BM, Ter Hoeve N, Lang-Schwarz C, Vieth M, Wellmann A, Kuehnle E, Kulik U , Riedel G, Reineke-Plaass T, Lehmann U, Koorman T, Derksen PW, Kreipe H, Christgen M. Microenvironment-induced restoration of cohesive growth associated with focal activation of P-cadherin expression in lobular breast carcinoma metastatic to the colon. J Pathol Clin Res. 2024 Mar;10(2):e12361. doi: 10.1002/2056-4538.12361. PMID: 38618992; PMCID: PMC10796744. Felgendreff P *, Lawrence JM*, Hosseiniasl SM, Jacobs JF, Amiot BP, Felgendreff L, Minshew A, Sultan A, Ahmadzada B, Rahe MC, Nyberg SL. Clinical characterization of a hypersensitivity mixed bacterial and fungal dermatitis in a translational model of porcine NASH . Front Cell Infect Microbiol. 2024 Jan 24;13:1277045. doi: 10.3389/fcimb.2023.1277045. PMID: 38327680; PMCID: PMC10847572. Schmalkuche K, Rother T, Besli S, Schwinzer R , Blasczyk R, Petersen B, Figueiredo C. Human PD-L1 overexpression decreases xenogeneic human T-cell immune responses towards porcine kidneys. Front Immunol. 2024 Jan 30;15:1279050. doi: 10.3389/fimmu.2024.1279050. PMID: 38352884; PMCID: PMC10861674. Ten Winkel M, Salama H, Timrott K, Kleine M, Kleine-Doepke D , Raehder-Johnson S, Meisel H, Rahberi NN, Abdelhadi S, Rückert F, Reissfelder C, Honselmann KC, Braun R, Faerber B, Lapshyn H, Keck T, Uhl W, Belyaev O, Wellner UF, Bolm L. Patient-reported outcomes at three months after pancreatic surgery for benign and malignant diseases - A prospective observational study. Pancreatology. 2024 Mar;24(2):314-322. doi: 10.1016/j.pan.2024.01.007. Epub 2024 Jan 18. PMID: 38310036. Krendl FJ, Fodor M, Buch ML, Singh J , Esser H, Cardini B, Resch T, Maglione M, Margreiter C, Schlosser L, Hell T, Schaefer B, Zoller H, Tilg H, Schneeberger S, Oberhuber R. The BAR Score Predicts and Stratifies Outcomes Following Liver Retransplantation: Insights From a Retrospective Cohort Study. Transpl Int. 2024 Jan 16;37:12104. doi: 10.3389/ti.2024.12104. PMID: 38304197; PMCID: PMC10833230. Lei Y, Wolf-van Buerck L, Honarpisheh M, Zhang Y, Schwinzer R , Petersen B, Seissler J. Neonatal islets from human PD-L1 transgenic pigs reduce immune cell activation and cellular rejection in humanized nonobese diabetic-scid IL2rγnull mice. Am J Transplant. 2024 Jan;24(1):20-29. doi: 10.1016/j.ajt.2023.08.026. Epub 2023 Aug 31. PMID: 37659605. 2023 Schmoeckel DM, Längin M, Reichart B, Abicht JM, Bender M, Michel S, Kamla CE, Denner J, Tönjes RR, Schwinzer R , Marckmann G, Wolf E, Brenner P, Hagl C. Current status of cardiac xenotransplantation. Thorac Cardiovasc Surg. 2023 Dec 28. doi: 10.1055/a-2235-8854 Nevermann N , Bode J, Vischer M, Krenzien F, Lurje G, Pelzer U, Fehrenbach U, Auer TA, Schmelzle M , Pratschke J, Schöning W. Perioperative outcome and long-term survival for intrahepatic cholangiocarcinoma after portal vein embolization and subsequent resection: A propensity-matched study. Eur J Surg Oncol. 2023 Dec;49(12):107100. doi: 10.1016/j.ejso.2023.107100. Epub 2023 Oct 5. PMID: 37918318. Frericks N, Brown RJP, Reinecke BM, Herrmann M, Brüggemann Y, Todt D, Miskey C, Vondran FWR , Steinmann E, Pietschmann T, Sheldon J. Hepatitis C virus cell culture adaptive mutations enhance cell culture propagation by multiple mechanisms but boost antiviral responses in primary human hepatocytes. bioRxiv [Preprint]. 2023 Nov 22:2023.11.22.568224. doi: 10.1101/2023.11.22.568224. PMID: 38045248; PMCID: PMC10690267. von Scheidt W, Reichart B, Meiser B, von Scheidt M, Sen P, Schwarz F, Harmel E, Bengel FM, Dick A, Ueberfuhr P, Reichenspurner H, Jaeckel E, Schwinzer R , Hagl C. Unique 40-year survival after heart transplantation with normal graft function and spontaneous operational tolerance. Clin Res Cardiol. 2023 Nov 20. doi: 10.1007/s00392-023-02341-x. Epub ahead of print. PMID: 37982861. Carriquí-Madroñal B, Sheldon J, Duven M, Stegmann C, Cirksena K, Wyler E, Zapatero-Belinchón FJ, Vondran FWR , Gerold G. The matrix metalloproteinase ADAM10 supports hepatitis C virus entry and cell-to-cell spread via its sheddase activity. PLoS Pathog. 2023 Nov 15;19(11):e1011759. doi: 10.1371/journal.ppat.1011759. PMID: 37967063; PMCID: PMC10650992. Iske J, Schroeter A, Knoedler S, Nazari-Shafti TZ, Wert L, Roesel MJ, Hennig F, Niehaus A, Kuehn C, Ius F, Falk V, Schmelzle M , Ruhparwar A, Haverich A, Knosalla C, Tullius SG, Vondran FWR , Wiegmann B. Pushing the boundaries of innovation: the potential of ex vivo organ perfusion from an interdisciplinary point of view. Front Cardiovasc Med. 2023 Oct 12;10:1272945. doi: 10.3389/fcvm.2023.1272945. PMID: 37900569; PMCID: PMC10602690. Dondorf F, Graf M, Deeb AA, Rohland O, Felgendreff P , Ardelt M, Settmacher U, Rauchfuss F. Pathogen detection in patients with perihilar cholangiocarcinoma: Implications for targeted perioperative antibiotic therapy. Hepatobiliary Pancreat Dis Int. 2023 Oct;22(5):512-518. doi: 10.1016/j.hbpd.2022.01.005. Epub 2022 Jan 31. PMID: 35153139. Iske J, Roesel MJ, Martin F, Schroeter A, Matsunaga T, Maenosono R, Tripathi U, Xiao Y, Nian Y, Caldarone BJ, Vondran FWR , Sage PT, Azuma H, Abdi R, Elkhal A, Pirtskhalava T, Tchkonia T, Kirkland JL, Zhou H, Tullius SG. Transplanting old organs promotes senescence in young recipients. Am J Transplant. 2023 Oct 31:S1600-6135(23)00803-1. doi: 10.1016/j.ajt.2023.10.013. Epub ahead of print. PMID: 37913871. Auer TA, Halskov S, Fehrenbach U, Nevermann NF , Pelzer U, Mohr R, Hamm B, Schöning W, Horst D, Ihlow J, Geisel D. Gd-EOB MRI for HCC subtype differentiation in a western population according to the 5th edition of the World Health Organization classification. Eur Radiol. 2023 Oct;33(10):6902-6915. doi: 10.1007/s00330-023-09669-y. Epub 2023 Apr 28. PMID: 37115216; PMCID: PMC10511376. Pokoyski C , Baars W, Windheim M, Reubold TF, Zischke J, Brinkmann A , Kay-Fedorov PC, Schwinzer R . Expression of viral CD45 ligand E3/49K on porcine cells reduces human anti-pig immune responses. Sci Rep. 2023 Oct 11;13(1):17218. doi: 10.1038/s41598-023-44316-y. PMID: 37821577; PMCID: PMC10567836. Nevermann N , Bode J, Vischer M, Krenzien F, Lurje G, Pelzer U, Fehrenbach U, Auer TA, Schmelzle M , Pratschke J, Schöning W. Perioperative outcome and long-term survival for intrahepatic cholangiocarcinoma after portal vein embolization and subsequent resection: A propensity-matched study. Eur J Surg Oncol. 2023 Oct 5;49(12):107100. doi: 10.1016/j.ejso.2023.107100. Epub ahead of print. PMID: 37918318. Kern B, Ashraf MI, Reutzel-Selke A, Mengwasser J , Polenz D, Michaelis E, Pratschke J, Tullius SG, Witzel C, Sauer IM. Moderate LMWH Anticoagulation Improves Success Rate of Hind Limb Allotransplantation in Mice . Plast Reconstr Surg Glob Open. 2023 Sep 15;11(9):e5249. doi: 10.1097/GOX.0000000000005249. PMID: 38152709; PMCID: PMC10752453. Åberg F, Sallinen V, Tuominen S, Adam R, Karam V, Mirza D, Heneghan MA, Line PD, Bennet W, Ericzon BG, Grat M, Lodge P, Rasmussen A, Schmelzle M , Thorburn D, Fondevila C, Helanterä I, Nordin A; European Liver and Intestine Transplant Association (ELITA). Cyclosporine vs. tacrolimus after liver transplantation for primary sclerosing cholangitis - a propensity score-matched intention-to-treat analysis. J Hepatol. 2023 Sep 16:S0168-8278(23)05100-0. doi: 10.1016/j.jhep.2023.08.031. Epub ahead of print. PMID: 37722533. Kulik U , Moesta C, Spanel R, Borlak J. Dysfunctional Cori and Krebs cycle and inhibition of lactate transporters constitute a mechanism of primary nonfunction of fatty liver allografts. Transl Res. 2023 Sep 17:S1931-5244(23)00146-9. doi: 10.1016/j.trsl.2023.09.006. Epub ahead of print. PMID: 37722450. Nevermann N , Bode J, Vischer M, Feldbrügge L , Knitter S, Krenzien F, Pelzer U, Fehrenbach U, Auer TA, Lurje G, Schmelzle M , Pratschke J, Schöning W. A surgical strategy for intrahepatic cholangiocarcinoma - the hilar first concept. Langenbecks Arch Surg. 2023 Aug 7;408(1):296. doi: 10.1007/s00423-023-03023-y. PMID: 37544932; PMCID: PMC10404569. Schmalkuche K, Schwinzer R , Wenzel N, Valdivia E, Petersen B, Blasczyk R, Figueiredo C. Downregulation of Swine Leukocyte Antigen Expression Decreases the Strength of Xenogeneic Immune Responses towards Renal Proximal Tubular Epithelial Cells. Int J Mol Sci. 2023 Aug 12;24(16):12711. doi: 10.3390/ijms241612711.PMID: 37628892. Free PMC article Bentler M, Hardet R, Ertelt M, Rudolf D, Kaniowska D, Schneider A, Vondran FWR , Schoeder CT, Delphin M, Lucifora J, Ott M, Hacker UT, Adriouch S, Büning H. Modifying immune responses to adeno-associated virus vectors by capsid engineering . Mol Ther Methods Clin Dev. 2023 Aug 22;30:576-592. doi: 10.1016/j.omtm.2023.08.015. PMID: 37693943; PMCID: PMC10485635. Nevermann N , Feldbrügge L , Knitter S, Krenzien F, Raschzok N, Lurje G, Schöning W, Pratschke J, Schmelzle M . Simplifying minimally invasive right hepatectomy. Surg Endosc. 2023 Jul;37(7):5430-5437. doi: 10.1007/s00464-023-09996-7. Epub 2023 Apr 7. PMID: 37029324; PMCID: PMC10322967. Kinast V, Andreica I, Ahrenstorf G, Gömer A, Elsner C, Schlienkamp S, Schrader JA, Klöhn M, Ulrich RG, Broering R, Vondran FWR , Todt D, Behrendt P, Dittmer U, Hamprecht A, Witte T, Baraliakos X, Steinmann E. Janus kinase-inhibition modulates hepatitis E virus infection. Antiviral Res. 2023 Sep;217:105690. doi: 10.1016/j.antiviral.2023.105690. Epub 2023 Jul 28. PMID: 37517633. Lange F, Garn J, Anagho HA, Vondran FWR , von Hahn T, Pietschmann T, Carpentier A. Hepatitis D virus infection, innate immune response and antiviral treatments in stem cell-derived hepatocytes. Liver Int. 2023 Jun 27. doi: 10.1111/liv.15655. Epub ahead of print. PMID: 37366005. Dasci S, Schrem H, Oldhafer F , Beetz O , Kleine-Döpke D, Vondran F , Beneke J, Sarisin A, Ramackers W . Learning surgical knot tying and suturing technique - effects of different forms of training in a controlled randomized trial with dental students. GMS J Med Educ. 2023 Jun 15;40(4):Doc48. doi: 10.3205/zma001630. PMID: 37560044; PMCID: PMC10407582. Schrader JA, Burkard TL, Brüggemann Y, Gömer A, Meister TL, Fu RM, Mehnert AK, Dao Thi VL, Behrendt P, Durantel D, Broering R, Vondran FWR , Todt D, Kinast V, Steinmann E. EGF receptor modulates HEV entry in human hepatocytes . Hepatology. 2023 Jun 1;77(6):2104-2117. doi: 10.1097/HEP.0000000000000308. Epub 2023 Feb 7. PMID: 36745934; PMCID: PMC10187617. Hosseiniasl SM, Felgendreff P , Tharwat M, Amiot B, AbuRmilah A, Minshew AM, Bornschlegl AM, Jalan-Sakrikar N, Smart M, Dietz AB, Huebert RC, Nyberg SL. Biodegradable biliary stents coated with mesenchymal stromal cells in a porcine choledochojejunostomy model. Cytotherapy. 2023 May;25(5):483-489. doi: 10.1016/j.jcyt.2023.01.014. Epub 2023 Feb 25. PMID: 36842850; PMCID: PMC10399303. Knitter S, Feldbrügge L , Nevermann N , Globke B, Galindo SAO, Winklmann T, Krenzien F, Haber PK, Malinka T, Lurje G, Schöning W, Pratschke J, Schmelzle M . Robotic versus laparoscopic versus open major hepatectomy - an analysis of costs and postoperative outcomes in a single-center setting. Langenbecks Arch Surg. 2023 May 29;408(1):214. doi: 10.1007/s00423-023-02953-x. PMID: 37247050; PMCID: PMC10226911. Sneidere M , Schrem HH, Mahlmann JC , Beetz O , Cammann S, Oldhafer F, Kleine M , Klempnauer J , Kaltenborn A, Zwirner U , Kulik U . Proposal of a Multivariable Prediction Model for Graded Morbidity after Liver Resection for Colorectal Metastases. Zentralbl Chir. 2023 Apr;148(2):147-155. English. doi: 10.1055/a-1243-0746. Epub 2020 Oct 22. PMID: 33091938. Marth AA, Auer TA, Walter-Rittel TC, Nevermann N , Krenzien F, Schmelzle M , Müller T, Kolck J, Wieners G, Geisel D, Gebauer B, Hamm B, Schöning W, Fehrenbach U. Gd-EOB-DTPA-MRCP to localize bile leakage after liver trauma and surgery: impact on treatment and outcome. Eur Radiol. 2023 Apr 13. doi: 10.1007/s00330-023-09608-x. Epub ahead of print. PMID: 37052657. Colasanti O, Burm R, Huang HE, Riedl T, Traut J, Gillich N, Li TF, Corneillie L, Faure-Dupuy S, Grünvogel O, Heide D, Lee JY, Tran CS, Merle U, Chironna M, Vondran FFW , Esser-Nobis K, Binder M, Bartenschlager R, Heikenwälder M, Meuleman P, Lohmann V. Comparison of HAV and HCV infections in vivo and in vitro reveals distinct patterns of innate immune evasion and activation. J Hepatol. 2023 Apr 29:S0168-8278(23)00309-4. doi: 10.1016/j.jhep.2023.04.023. Epub ahead of print. PMID: 37121436. Panagiotakis E, Selzer T, Böhm G, Schrem H, Vondran FWR , Qu Z, Ockenga J, Hertenstein B, Winterhalter M, Bektas H. Preoperative hemoglobin levels, extended resections and the body mass index influence survival after pancreaticoduodenectomy. Langenbecks Arch Surg. 2023 Mar 20;408(1):124. doi: 10.1007/s00423-023-02863-y. PMID: 36935457. Bojkova D, Reus P, Panosch L, Bechtel M, Rothenburger T, Kandler JD, Pfeiffer A, Wagner JUG, Shumliakivska M, Dimmeler S, Olmer R, Martin U, Vondran FWR , Toptan T, Rothweiler F, Zehner R, Rabenau HF, Osman KL, Pullan ST, Carroll MW, Stack R, Ciesek S, Wass MN, Michaelis M, Cinatl J Jr. Identification of novel antiviral drug candidates using an optimized SARS-CoV-2 phenotypic screening platform. iScience. 2023 Feb 17;26(2):105944. doi: 10.1016/j.isci.2023.105944. Epub 2023 Jan 7. PMID: 36644320; PMCID: PMC9822553. Schmelzle M , Krenzien F, Dahlke P, Krombholz A, Nevermann N , Feldbrügge L , Winter A, Schöning W, Benzing C, Pratschke J, Neudecker J. Validation of the Enhanced Recovery after Surgery (ERAS) society recommendations for liver surgery: a prospective, observational study. Hepatobiliary Surg Nutr. 2023 Feb 28;12(1):20-36. doi: 10.21037/hbsn-21-294. Epub 2022 Feb 9. PMID: 36860244; PMCID: PMC9944541. Nevermann N , Feldbrügge L , Krenzien F, Ortiz Galindo S, Knitter S, Haber P, Malinka T, Lurje G, Schöning W, Schmelzle M , Pratschke J. Robotic Liver Surgery: Technical Advantages Over Laparoscopic Technique Based on Parameters of Surgical Complexity and Perioperative Outcomes. J Laparoendosc Adv Surg Tech A. 2023 Jan;33(1):56-62. doi: 10.1089/lap.2022.0129. Epub 2022 Jul 26. PMID: 35877812. von Horn C, Zlatev H , Lüer B, Malkus L, Ting S, Minor T. The impact of oxygen supply and erythrocytes during normothermic kidney perfusion. Sci Rep. 2023 Feb 3;13(1):2021. doi: 10.1038/s41598-023-29031-y. PMID: 36737505; PMCID: PMC9898236. Leiskau C, Junge N, Mutschler FE, Laue T, Ohlendorf J, Richter N , Vondran FWR , Pfister ED, Baumann U. Long-Term Outcome Following Liver Transplantation for Primary Hepatic Tumors-A Single Centre Observational Study over 40 Years. Children (Basel). 2023 Jan 22;10(2):202. doi: 10.3390/children10020202. PMID: 36832331; PMCID: PMC9954409. Verlaat L, Riesner K, Kalupa M, Jung B, Mertlitz S, Schwarz C, Mengwasser J , Fricke C, Penack O. Novel pre-clinical mouse models for chronic Graft-versus-Host Disease. Front Immunol. 2023 Jan 24;13:1079921. doi: 10.3389/fimmu.2022.1079921. PMID: 36761159; PMCID: PMC9902926. 2022 Seika P, Marz S, Geffers C, Adam T, Feldbrügge L , Jara M, Pratschke J, Rau B. The Clinical Importance of Preoperative Rectal Swabs in Patients after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy. Visc Med. 2022 Dec;38(6):376-383. doi: 10.1159/000526001. Epub 2022 Aug 18. PMID: 36589250; PMCID: PMC9801311. Junge N, Artmann A, Richter N, Vondran FWR , Böthig D, Sasse M, Köditz H, Baumann U, Beerbaum P, Kaussen T. Intra-Abdominal Hypertension and Compartment Syndrome after Pediatric Liver Transplantation: Incidence, Risk Factors and Outcome. Children (Basel). 2022 Dec 18;9(12):1993. doi: 10.3390/children9121993. PMID: 36553436; PMCID: PMC9777324. Beetz O , Cammann S , Weigle CA , Sieg L, Eismann H, Johanning K, Falk CS, Krech T, Oldhafer F , Vondran FWR . Interleukin-18 and High-Mobility-Group-Protein B1 are Early and Sensitive Indicators for Cell Damage During Normothermic Machine Perfusion after Prolonged Cold Ischemic Storage of Porcine Liver Grafts. Transpl Int. 2022 Oct 20;35:10712. doi: 10.3389/ti.2022.10712. PMID: 36338535; PMCID: PMC9630326. Hensen B, Hellms S, Werlein C, Jonigk D, Gronski PA, Bruesch I, Rumpel R, Wittauer EM, Vondran FWR , Parker DL, Wacker F, Gutberlet M. Correction of heat-induced susceptibility changes in respiratory-triggered 2D-PRF-based thermometry for monitoring of magnetic resonance-guided hepatic microwave ablation in a human-like in vivo porcine model. Int J Hyperthermia. 2022;39(1):1387-1396. doi: 10.1080/02656736.2022.2138987. PMID: 36336401. Schmelzle M , Benzing C, Fischer L, Herden U, Sterneck M, Settmacher U, Bauschke A, Neumann U, Pelzer U, Müller T, Strassburg C, Lang H, Becker T, Königsrainer A, Nadalin S, Quante M, Paul A, Friess H, Klempnauer J, Richter N, Vondran F , Pascher A, Rösch T, Schöning W, Krenzien F, Öllinger R, Seehofer D, Neuhaus P, Pratschke J. Feasibility and Efficacy of Adjuvant Chemotherapy With Gemcitabine After Liver Transplantation for Perihilar Cholangiocarcinoma - A Multi-Center, Randomized, Controlled Trial (pro-duct001). Front Oncol. 2022 Oct 6;12:910871. doi: 10.3389/fonc.2022.910871. PMID: 36330499; PMCID: PMC9624225. Schnitzler LJ, Oldhafer F , Kulik U, Klempnauer J, Reese T, Oldhafer KJ, Beetz O . Preoperative leukocytosis is an independent risk factor for morbidity and survival after resection of colorectal liver metastases. ANZ J Surg. 2022 Oct;92(10):2551-2559. doi: 10.1111/ans.17845. Epub 2022 Jun 20. PMID: 35723493. Bukova M, Funken D, Pfister ED, Baumann U, Richter N, Vondran FFW , Happel CM, Bertram H. Long-term outcome of primary percutaneous stent angioplasty for pediatric posttransplantation portal vein stenosis. Liver Transpl. 2022 Sep;28(9):1463-1474. doi: 10.1002/lt.26488. Epub 2022 May 20. PMID: 35447015. Hoenow S, Yan K, Noll J, Groneberg M, Casar C, Lory NC, Vogelsang M, Hansen C, Wolf V , Fehling H, Sellau J, Mittrücker HW, Lotter H. The Properties of Proinflammatory Ly6Chi Monocytes Are Differentially Shaped by Parasitic and Bacterial Liver Infections. Cells. 2022 Aug 16;11(16):2539. doi: 10.3390/cells11162539. PMID: 36010615; PMCID: PMC9406626. Canesin G, Feldbrügge L , Wei G, Janovicova L, Janikova M, Csizmadia E, Ariffin J, Hedblom A, Herbert ZT, Robson SC, Celec P, Swanson KD, Nasser I, Popov YV, Wegiel B. Heme oxygenase-1 mitigates liver injury and fibrosis via modulation of LNX1/Notch1 pathway in myeloid cells. iScience. 2022 Aug 20;25(9):104983. doi: 10.1016/j.isci.2022.104983. PMID: 36093061; PMCID: PMC9450142. Qu B, Nebioglu F, Leuthold MM, Ni Y, Mutz P, Beneke J, Erfle H, Vondran FWR , Bartenschlager R, Urban S. Dual role of neddylation in transcription of hepatitis B virus RNAs from cccDNA and production of viral surface antigen. JHEP Rep. 2022 Aug 7;4(10):100551. doi: 10.1016/j.jhepr.2022.100551. PMID: 36124123; PMCID: PMC9482114. Meister TL, Brüggemann Y, Nocke MK, Ulrich RG, Schuhenn J, Sutter K, Gömer A, Bader V, Winklhofer KF, Broering R, Verhoye L, Meuleman P, Vondran FWR , Camuzet C, Cocquerel L, Todt D, Steinmann E. A ribavirin-induced ORF2 single-nucleotide variant produces defective hepatitis E virus particles with immune decoy function. Proc Natl Acad Sci U S A. 2022 Aug 23;119(34):e2202653119. doi: 10.1073/pnas.2202653119. Epub 2022 Aug 15. PMID: 35969792; PMCID: PMC9407633. Praditya DF, Klöhn M, Brüggemann Y, Brown LE, Porco JA Jr, Zhang W, Kinast V, Kirschning A, Vondran FWR , Todt D, Steinmann E. Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication. Antiviral Res. 2022 Aug;204:105359. doi: 10.1016/j.antiviral.2022.105359. Epub 2022 Jun 18. PMID: 35728703; PMCID: PMC9731315. Seika P, Biebl M, Raakow J, Berndt N, Feldbrügge L , Maurer MM, Dobrindt E, Thuss-Patience P, Pratschke J, Denecke C. The Association between Neoadjuvant Radio-Chemotherapy and Prolonged Healing of Anastomotic Leakage after Esophageal Resection Treated with EndoVAC Therapy. J Clin Med. 2022 Aug 16;11(16):4773. doi: 10.3390/jcm11164773. PMID: 36013012; PMCID: PMC9410280. Beetz O , Oldhafer F , Weigle CA , Cammann S , DeTemple D , Sieg L, Eismann H, Palmaers T, Vondran FWR . Porcine Liver Transplantation Without Veno-venous Bypass As an Extended Criteria Donor Model. J Vis Exp. 2022 Aug 17;(186). doi: 10.3791/64152. PMID: 36063020. Schmelzle M , Feldbrügge L , Ortiz Galindo SA, Moosburner S, Kästner A, Krenzien F, Benzing C, Biebl M, Öllinger R, Malinka T, Schöning W, Pratschke J. Robotic vs. laparoscopic liver surgery: a single-center analysis of 600 consecutive patients in 6 years. Surg Endosc. 2022 Aug;36(8):5854-5862. doi: 10.1007/s00464-021-08770-x. Epub 2022 May 31. PMID: 35641702; PMCID: PMC9283354. Hillebrandt KH, Moosburner S, Winter A, Nevermann N , Raschzok N, Malinka T, Sauer IM, Schmelzle M, Pratschke J, Chopra S. The influence of the COVID-19 pandemic on surgical therapy and care: a cross-sectional study. BMC Surg. 2022 Jul 5;22(1):259. doi: 10.1186/s12893-022-01708-7. PMID: 35791027; PMCID: PMC9253238. Benzing C, Haiden LM, Krenzien F, Mieg A, Wolfsberger A, Atik CF, Nevermann N , Fehrenbach U, Schöning W, Schmelzle M , Pratschke J. Textbook outcome after major hepatectomy for perihilar cholangiocarcinoma - definitions and influencing factors. Langenbecks Arch Surg. 2022 Jun;407(4):1561-1573. doi: 10.1007/s00423-022-02467-y. Epub 2022 Mar 4. PMID: 35246771; PMCID: PMC9283152. Nevermann N , Schöning W, Malinka T, Fehrenbach U, Müller T, Pratschke J, Schmelzle M . Gallengangsverletzung im Rahmen der laparoskopischen Cholezystektomie : Klassifikation, Erkennung und Reparation [Bile duct injuries during laparoscopic cholecystectomy : Classification, recognition and repair]. Chirurgie (Heidelb). 2022 Jun;93(6):554-565. German. doi: 10.1007/s00104-022-01592-0. Epub 2022 Feb 16. PMID: 35171304. Assfalg V, Miller G, Stocker F, van Meel M, Groenevelt T, Tieken I, Ankerst D, Renders L, Novotny A, Hartmann D, Jell A, Rahmel A, Wahba R, Mühlfeld A, Bouts A, Ysebaert D, Globke B, Jacobs-Tulleneers-Thevissen D, Piros L, Stippel D, Heller K, Eisenberger U, van Laecke S, Weimer R, Rosenkranz AR, Berger S, Fischer L, Kliem V, Vondran F , Sester U, Schneeberger S, Harth A, Kuypers D, Függer R, Arnol M, Christiaans M, Weinmann-Menke J, Krüger B, Hilbrands L, Banas B, Hakenberg O, Minnee R, Schwenger V, Heyne N, van Zuilen A, Reindl-Schwaighofer R, Lopau K, Hüser N, Heemann U. Kidney Transplantation After Rescue Allocation-the Eurotransplant Experience: A Retrospective Multicenter Outcome Analysis. Transplantation. 2022 Jun 1;106(6):1215-1226. doi: 10.1097/TP.0000000000003964. Epub 2022 Oct 4. PMID: 34608103. Oldhafer F , Cammann S , Beetz O , Pfister E, Junge N, Laue T, Richter N, Lurje G, Klempnauer J, Baumann U, Vondran FWR . Hypothermic Oxygenated Perfusion for Transplantation of a Pediatric Extended Right Lobe: Report of the First Case. Transplantation. 2022 Jun 1;106(6):e322-e323. doi: 10.1097/TP.0000000000004062. Epub 2022 May 23. PMID: 35616916. Feldbrügge L , Ortiz Galindo SA, Frisch O, Benzing C, Krenzien F, Riddermann A , Kästner A, Nevermann NF , Malinka T, Schöning W, Pratschke J, Schmelzle M. Safety and feasibility of robotic liver resection after previous abdominal surgeries. Surg Endosc. 2022 May;36(5):2842-2849. doi: 10.1007/s00464-021-08572-1. Epub 2021 Jun 2. PMID: 34076760. Mederacke I, Filliol A, Affo S, Nair A, Hernandez C, Sun Q, Hamberger F, Brundu F, Chen Y, Ravichandra A, Huebener P, Anke H, Shi H, Martínez García de la Torre RA, Smith JR, Henderson NC, Vondran FWR , Rothlin CV, Baehre H, Tabas I, Sancho-Bru P, Schwabe RF. The purinergic P2Y14 receptor links hepatocyte death to hepatic stellate cell activation and fibrogenesis in the liver. Sci Transl Med. 2022 Apr 6;14(639):eabe5795. doi: 10.1126/scitranslmed.abe5795. Epub 2022 Apr 6. PMID: 35385339; PMCID: PMC9436006. Rau B, Feldbrügge L , Gronau F , Alberto Vilchez ME, Thuss-Patience P, Bonnot PE, Glehen O. Indication of Hyperthermic Intraperitoneal Chemotherapy in Gastric Cancer (Gastripec, Gastrichip). Visc Med. 2022 Apr;38(2):81-89. doi: 10.1159/000522604. Epub 2022 Feb 23. PMID: 35614895; PMCID: PMC9082209. Kettler B, Jaeckel E, Taubert R, Wedemeyer HH, Klempnauer J, Richter N, Neubert L, Vondran FWR . Liver Transplantation After Organ Donation Due to Hydrogen Sulfide Intoxication: Report of the First Case. Transplantation. 2022 Apr 1;106(4):e247-e248. doi: 10.1097/TP.0000000000004018. PMID: 35333851. Reinecke B, Frericks N, Lauber C, Dinkelborg K, Matthaei A, Vondran FWR , Behrendt P, Haid S, Brown RJP, Pietschmann T. The Human Liver-Expressed Lectin CD302 Restricts Hepatitis C Virus Infection. J Virol. 2022 Apr 13;96(7):e0199521. doi: 10.1128/jvi.01995-21. Epub 2022 Mar 17. PMID: 35297672; PMCID: PMC9006913. Cammann S , Karabulut S, DeTemple DE , Oldhafer F , Kulik U, Schroeter A, Vondran FWR, Klempnauer J, Kleine M, Timrott K, Beetz O . Antibiotic-Resistant Bacteria Colonizing the Bile Duct Are Associated with Increased Morbidity and Mortality after Resection of Extrahepatic Cholangiocarcinoma. Surg Infect (Larchmt). 2022 Apr;23(3):270-279. doi: 10.1089/sur.2021.117. Epub 2022 Feb 16. PMID: 35172114. Rodieck W, Hallensleben M, Robert J, Beetz O , Grannas G, Cammann S , Oldhafer F , Klempnauer J, Vondran FWR , Kulik U. Impact of perioperative blood transfusions on postoperative renal function and survival after resection of colorectal liver metastases. World J Surg Oncol. 2022 Mar 30;20(1):100. doi: 10.1186/s12957-022-02559-5. PMID: 35354485; PMCID: PMC8966349. Krause N, Mengwasser J , Phithak E, Beato F, Appis M, Milford EL, Pratschke J, Sauer I, Kuehl A, Vogel A, Goodyear M, Hammerich L, Tacke F, Haas JF, Müller T, Utku N. Immune Regulatory 1 Cells: A Novel and Potent Subset of Human T Regulatory Cells. Front Immunol. 2022 Feb 8;12:790775. doi: 10.3389/fimmu.2021.790775. PMID: 35222353; PMCID: PMC8867398. Saunders EA, Engel B, Höfer A, Hartleben B, Vondran FWR , Richter N, Potthoff A, Zender S, Wedemeyer H, Jaeckel E, Taubert R. Outcome and safety of a surveillance biopsy guided personalized immunosuppression program after liver transplantation. Am J Transplant. 2022 Feb;22(2):519-531. doi: 10.1111/ajt.16817. Epub 2021 Sep 13. PMID: 34455702. Ortiz Galindo SA, Haber PK, Benzing C, Krenzien F, Riddermann A , Frisch O, Schöning W , Schmelzle M , Pratschke J, Feldbrügge L . Safety of intermittent Pringle maneuver during minimally invasive liver resection in patients with hepatocellular carcinoma with and without cirrhosis. Langenbecks Arch Surg. 2022 Feb;407(1):235-244. doi: 10.1007/s00423-021-02361-z. Epub 2021 Nov 17. PMID: 34787706; PMCID: PMC8847278. Junge N, Di Giorgio A, Girard M, Demir Z, Kaminska D, Janowska M, Urbonas V, Varnas D, Maggiore G, Alterio T, Leiskau C, Vondran FWR , Richter N, D'Antiga L, Mikolajczyk R, Pfister ED, Baumann U. Cold Ischemia Time and Graft Fibrosis Are Associated with Autoantibodies after Pediatric Liver Transplantation: A Retrospective Cohort Study of the European Reference Network TransplantChild. Children (Basel). 2022 Feb 17;9(2):275. doi: 10.3390/children9020275. PMID: 35204995; PMCID: PMC8870233. Vogel A, Sterneck M, Vondran F , Waidmann O, Klein I, Lindig U, Nadalin S, Settmacher U, Tacke F, Schlitt HJ, Wege H. Der Einsatz der immunonkologischen Therapie beim hepatozellulären Karzinom im Kontext der Lebertransplantation Eine interdisziplinäre Risiko-Nutzen-Abwägung [The use of immuno-oncologic therapy in hepatocellular carcinoma in the context of liver transplantation. An interdisciplinary benefit/risk assessment]. Z Gastroenterol. 2022 Feb;60(2):184-191. German. doi: 10.1055/a-1649-8643. Epub 2021 Oct 20. PMID: 34670296. Honerkamp I, Sandmann L, Richter N, Manns MP, Voigtländer T, Vondran FWR , von Hahn T. Surgical Procedures in Patients Awaiting Liver Transplantation: Complications and Impact on the Liver Function . J Clin Exp Hepatol. 2022 Jan-Feb;12(1):68-79. doi: 10.1016/j.jceh.2021.03.011. Epub 2021 Apr 2. PMID: 35068787; PMCID: PMC8766540. Krenzien F, Nevermann N , Krombholz A, Benzing C, Haber P, Fehrenbach U, Lurje G, Pelzer U, Pratschke J, Schmelzle M , Schöning W. Treatment of Intrahepatic Cholangiocarcinoma-A Multidisciplinary Approach. Cancers (Basel). 2022 Jan 12;14(2):362. doi: 10.3390/cancers14020362. PMID: 35053523; PMCID: PMC8773654. Kurreck A, Gronau F , Alberto Vilchez ME, Abels W, Enghard P, Brandl A, Francis R, Föhre B, Lojewski C, Pratschke J, Thuss-Patience P, Modest D, Rau B, Feldbrügge L . Sodium Thiosulfate Reduces Acute Kidney Injury in Patients Undergoing Cytoreductive Surgery Plus Hyperthermic Intraperitoneal Chemotherapy with Cisplatin: A Single-Center Observational Study. Ann Surg Oncol. 2022 Jan;29(1):152-162. doi: 10.1245/s10434-021-10508-x. Epub 2021 Aug 4. PMID: 34350529; PMCID: PMC8677645. Baron Y, Sens J, Lange L, Nassauer L, Klatt D, Hoffmann D, Kleppa MJ, Barbosa PV, Keisker M, Steinberg V, Suerth JD, Vondran FWR , Meyer J, Morgan M, Schambach A, Galla M. Improved alpharetrovirus-based Gag.MS2 particles for efficient and transient delivery of CRISPR-Cas9 into target cells. Mol Ther Nucleic Acids. 2022 Jan 1;27:810-823. doi: 10.1016/j.omtn.2021.12.033. PMID: 35141043; PMCID: PMC8801357. 2021 Yang T, Poenisch M, Khanal R, Hu Q, Dai Z, Li R, Song G, Yuan Q, Yao Q, Shen X, Taubert R, Engel B, Jaeckel E, Vogel A, Falk CS, Schambach A, Gerovska D, Araúzo-Bravo MJ, Vondran FWR , Cantz T, Horscroft N, Balakrishnan A, Chevessier F, Ott M, Sharma AD. Therapeutic HNF4A mRNA attenuates liver fibrosis in a preclinical model. J Hepatol. 2021 Dec;75(6):1420-1433. doi: 10.1016/j.jhep.2021.08.011. Epub 2021 Aug 25. Erratum in: J Hepatol. 2022 Jul;77(1):270. PMID: 34453962. Engelmann C, Herber A, Franke A, Bruns T, Reuken P, Schiefke I, Zipprich A, Zeuzem S, Goeser T, Canbay A, Berg C, Trebicka J, Uschner FE, Chang J, Mueller T, Aehling N, Schmelzle M , Splith K , Lammert F, Lange CM, Sarrazin C, Trautwein C, Manns M, Häussinger D, Pfeiffenberger J, Galle PR, Schmiedeknecht A, Berg T. Granulocyte-colony stimulating factor (G-CSF) to treat acute-on-chronic liver failure: A multicenter randomized trial (GRAFT study). J Hepatol. 2021 Dec;75(6):1346-1354. doi: 10.1016/j.jhep.2021.07.033. Epub 2021 Aug 5. PMID: 34364917. Czigany Z, Pratschke J, Froněk J, Guba M, Schöning W, Raptis DA, Andrassy J, Kramer M, Strnad P, Tolba RH, Liu W, Keller T, Miller H, Pavicevic S, Uluk D, Kocik M, Lurje I, Trautwein C, Mehrabi A, Popescu I, Vondran FWR , Ju C, Tacke F, Neumann UP, Lurje G. Hypothermic Oxygenated Machine Perfusion Reduces Early Allograft Injury and Improves Post-transplant Outcomes in Extended Criteria Donation Liver Transplantation From Donation After Brain Death: Results From a Multicenter Randomized Controlled Trial (HOPE ECD-DBD). Ann Surg. 2021 Nov 1;274(5):705-712. doi: 10.1097/SLA.0000000000005110. PMID: 34334635. Nicolay W, Moeller R, Kahl S, Vondran FWR , Pietschmann T, Kunz S, Gerold G. Characterization of RNA Sensing Pathways in Hepatoma Cell Lines and Primary Human Hepatocytes. Cells. 2021 Nov 4;10(11):3019. doi: 10.3390/cells10113019. PMID: 34831243; PMCID: PMC8616302. Waldron LS, Cerisuelo MC, Lo D, Sayed BA, Vilca-Melendez H, Magliocca J, Lurz E, Baumann U, Vondran FWR , Richter N, von Schweinitz D, Guba M, Muensterer OJ, Berger M. Diaphragmatic Hernia following Pediatric Liver Transplantation: An Underappreciated Complication Prone to Recur. Eur J Pediatr Surg. 2021 Oct;31(5):396-406. doi: 10.1055/s-0040-1716882. Epub 2020 Nov 13. PMID: 33186999. Aburahma K, Salman J, Engel B, Vondran FWR , Greer M, Boethig D, Siemeni T, Avsar M, Schwerk N, Müller C, Taubert R, Hoeper MM, Welte T, Wedemeyer HH, Richter N, Warnecke G, Tudorache I, Haverich A, Kuehn C, Grannas G, Ius F. Liver-first strategy for a combined lung and liver transplant in patients with cystic fibrosis. Eur J Cardiothorac Surg. 2021 Oct 22;60(4):822-830. doi: 10.1093/ejcts/ezab164. PMID: 33956976. Reichart B, Längin M, Denner J, Schwinzer R , Cowan PJ, Wolf E. Pathways to Clinical Cardiac Xenotransplantation. Transplantation. 2021 Sep 1;105(9):1930-1943. doi: 10.1097/TP.0000000000003588. PMID: 33350675. Hillebrandt K, Nevermann N , Globke B, Moosburner S, Schmelzle M , Pratschke J. Auswirkung der COVID-19-Pandemie auf die hepatopankreatobiliäre Chirurgie und die Organtransplantation [Impact of the COVID-19 pandemic on hepato-pancreato-biliary surgery and organ transplantation]. Chirurg. 2021 Oct;92(10):918-923. German. doi: 10.1007/s00104-021-01463-0. Epub 2021 Jul 23. PMID: 34297148; PMCID: PMC8299733. Beetz O , Timrott A, Weigle CA , Schroeter A, Cammann S, Klempnauer J, Vondran FWR , Oldhafer F . Proposal of a New Definition of "Very Early" Intrahepatic Cholangiocarcinoma-A Retrospective Single-Center Analysis. J Clin Med. 2021 Sep 9;10(18):4073. doi: 10.3390/jcm10184073. PMID: 34575181; PMCID: PMC8468271. Flemming G, Baumann U, Richter N, Vondran F , Tümmler B, Dittrich AM, Müller C, Vogel M, Pfister ED. Survival Benefits Following Liver Transplantation: A Matched-pair Analysis in Pediatric Patients With Cystic Fibrosis. J Pediatr Gastroenterol Nutr. 2021 Sep 1;73(3):385-390. doi: 10.1097/MPG.0000000000003194. PMID: 34091543. Visseren T, Erler NS, Polak WG, Adam R, Karam V, Vondran FWR , Ericzon BG, Thorburn D, IJzermans JNM, Paul A, van der Heide F, Taimr P, Nemec P, Pirenne J, Romagnoli R, Metselaar HJ, Darwish Murad S; European Liver and Intestine Transplantation Association (ELITA). Recurrence of primary sclerosing cholangitis after liver transplantation - analysing the European Liver Transplant Registry and beyond. Transpl Int. 2021 Aug;34(8):1455-1467. doi: 10.1111/tri.13925. Epub 2021 Jun 28. PMID: 34028110; PMCID: PMC8456806. Blossey RD , Kleine-Döpke D , Ringe KI, Pöhnert D, Ringe B, Klempnauer J, Beetz O . Recurrent Hurthle cell thyroid carcinoma does not preclude long-term survival: a case report and review of the literature. J Med Case Rep. 2021 Aug 11;15(1):399. doi: 10.1186/s13256-021-02987-z. PMID: 34376229; PMCID: PMC8356425. Cordes S, Mokhtari Z, Bartosova M, Mertlitz S, Riesner K, Shi Y, Mengwasser J , Kalupa M, McGeary A, Schleifenbaum J, Schrezenmeier J, Bullinger L, Diaz-Ricart M, Palomo M, Carrreras E, Beutel G, Schmitt CP, Beilhack A, Penack O. Endothelial damage and dysfunction in acute graft-versus-host disease. Haematologica. 2021 Aug 1;106(8):2147-2160. doi: 10.3324/haematol.2020.253716. PMID: 32675225; PMCID: PMC8327719. Nevermann N , Wiering L, Wu H, Moroder P, Brandl A, Globke B, Krenzien F, Raschzok N, Schöning W, Lurje G, Öllinger R, Schmelzle M , Pratschke J, Ritschl PV. Transplantation programs facing lack of empirical evidence on SARS-CoV-2 vaccination: A society recommendation consensus update. Transpl Infect Dis. 2021 Aug;23(4):e13696. doi: 10.1111/tid.13696. Epub 2021 Jul 28. PMID: 34288294; PMCID: PMC8420432. Benzing C, Krenzien F, Mieg A, Wolfsberger A, Andreou A, Nevermann N , Pelzer U, Fehrenbach U, Haiden LM, Öllinger R, Schöning W, Schmelzle M , Pratschke J. A tailored approach in lymph node-positive perihilar cholangiocarcinoma. Langenbecks Arch Surg. 2021 Aug;406(5):1499-1509. doi: 10.1007/s00423-021-02154-4. Epub 2021 Jun 1. Erratum in: Langenbecks Arch Surg. 2022 Dec;407(8):3903-3905. PMID: 34075473; PMCID: PMC8370897. Leiskau C, Junge N, Pfister ED, Goldschmidt I, Mutschler F, Laue T, Ohlendorf J, Nasser H, Beneke J, Richter N, Vondran F , Baumann U. Recipient-Specific Risk Factors Impairing Patient and Graft Outcome after Pediatric Liver Transplantation-Analysis of 858 Transplantations in 38 Years. Children (Basel). 2021 Jul 27;8(8):641. doi: 10.3390/children8080641. PMID: 34438532; PMCID: PMC8393592. Albrecht T, Hildenbrand T, Beneke J, Offergeld C, Ramackers W . Qualitätssicherungssystem zur Bewertung eines HNO-Facharztrepetitoriums [Quality management in a postgraduate refresher course in otolaryngology]. HNO. 2021 Jul;69(7):568-574. German. doi: 10.1007/s00106-021-01065-6. Epub 2021 Jun 9. PMID: 34106281; PMCID: PMC8233240. Busche S, John K, Wandrer F, Vondran FWR , Lehmann U, Wedemeyer H, Essmann F, Schulze-Osthoff K, Bantel H. BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment. Cell Death Dis. 2021 Jul 26;12(8):736. doi: 10.1038/s41419-021-04020-z. PMID: 34312366; PMCID: PMC8313681. Beetz O , Thies J, Weigle CA , Ius F, Winkler M, Bara C, Richter N, Klempnauer J, Warnecke G, Haverich A, Avsar M, Grannas G. Simultaneous heart-kidney transplantation results in respectable long-term outcome but a high rate of early kidney graft loss in high-risk recipients - a European single center analysis. BMC Nephrol. 2021 Jul 9;22(1):258. doi: 10.1186/s12882-021-02430-x. PMID: 34243724; PMCID: PMC8268408. Zapatero-Belinchón FJ, Ötjengerdes R, Sheldon J, Schulte B, Carriquí-Madroñal B, Brogden G, Arroyo-Fernández LM, Vondran FWR , Maasoumy B, von Hahn T, Gerold G. Interdependent Impact of Lipoprotein Receptors and Lipid-Lowering Drugs on HCV Infectivity. Cells. 2021 Jun 29;10(7):1626. doi: 10.3390/cells10071626. PMID: 34209751; PMCID: PMC8303410. Feldbrügge L , Langenscheidt A, Krenzien F, Schulz M, Krezdorn N, Kamali K, Hinz A, Bartels M, Fikatas P, Schmelzle M , Pratschke J, Benzing C. Health-Related Quality of Life and Mental Health after Surgical Treatment of Hepatocellular Carcinoma in the Era of Minimal-Invasive Surgery: Resection versus Transplantation. Healthcare (Basel). 2021 Jun 9;9(6):694. doi: 10.3390/healthcare9060694. PMID: 34207501; PMCID: PMC8228687. Gronau F , Jara M, Feldbrügge L , Wolf V , Oeff A, Rau B. Zytoreduktive Chirurgie und hypertherme intraperitoneale Chemotherapie beim Magenkarzinom [Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in gastric cancer]. Chirurg. 2021 Jun;92(6):522-527. German. doi: 10.1007/s00104-021-01371-3. Epub 2021 Feb 23. PMID: 33620502. Leiskau C, Samuel S, Pfister ED, Junge N, Beneke J, Stupak J, Richter N, Vondran F , Schrem H, Baumann U. Low-dose steroids do make a difference: Independent risk factors for impaired linear growth after pediatric liver transplantation. Pediatr Transplant. 2021 Jun;25(4):e13989. doi: 10.1111/petr.13989. Epub 2021 Mar 10. PMID: 33689189. Aregay A, Engel B, Port K, Vondran FWR , Bremer B, Niehaus C, Khera T, Richter N, Jaeckel E, Cornberg M, Taubert R, Wedemeyer H. Distinct Immune Imprints of Post-Liver Transplantation Hepatitis C Persist Despite Viral Clearance. Liver Transpl. 2021 Jun;27(6):887-899. doi: 10.1002/lt.26031. PMID: 33641215. Oldhafer F , Wittauer EM, Beetz O , Weigle CA , Sieg L, Eismann H, Braubach P, Bock M, Jonigk D, Johanning K, Vondran FWR . Supportive Hepatocyte Transplantation after Partial Hepatectomy Enhances Liver Regeneration in a Preclinical Pig Model. Eur Surg Res. 2021;62(4):238-247. doi: 10.1159/000516690. Epub 2021 May 27. PMID: 34044396. Mederacke YS, Nienen M, Jarek M, Geffers R, Hupa-Breier K, Babel N, Reinke P, Mederacke I, Vondran FWR , Jonigk D, Wedemeyer H, Jaeckel E. T cell receptor repertoires within liver allografts are different to those in the peripheral blood. J Hepatol. 2021 May;74(5):1167-1175. doi: 10.1016/j.jhep.2020.12.014. Epub 2020 Dec 18. PMID: 33347951. Kamali K, Schmelzle M , Kamali C, Brunnbauer P, Splith K , Leder A, Berndt N, Hillebrandt KH, Raschzok N, Feldbrügge L, Felsenstein M, Gaßner J, Ritschl P, Lurje G, Schöning W, Benzing C, Pratschke J, Krenzien F. Sensing Acute Cellular Rejection in Liver Transplant Patients Using Liver-Derived Extracellular Particles: A Prospective, Observational Study. Front Immunol. 2021 May 5;12:647900. doi: 10.3389/fimmu.2021.647900. PMID: 34025656; PMCID: PMC8131523. Sandhu B, Perez-Matos MC, Tran S, Singhal G, Syed I, Feldbrügge L , Mitsuhashi S, Pelletier J, Huang J, Yalcin Y, Csizmadia E, Tiwari-Heckler S, Enjyoji K, Sévigny J, Maratos-Flier E, Robson SC, Jiang ZG. Global deletion of NTPDase3 protects against diet-induced obesity by increasing basal energy metabolism. Metabolism. 2021 May;118:154731. doi: 10.1016/j.metabol.2021.154731. Epub 2021 Feb 23. PMID: 33631144; PMCID: PMC8052311. Ostroumov D, Duong S, Wingerath J, Woller N, Manns MP, Timrott K, Kleine M, Ramackers W , Roessler S, Nahnsen S, Czemmel S, Dittrich-Breiholz O, Eggert T, Kühnel F, Wirth TC. Transcriptome Profiling Identifies TIGIT as a Marker of T-Cell Exhaustion in Liver Cancer. Hepatology. 2021 Apr;73(4):1399-1418. doi: 10.1002/hep.31466. Erratum in: Hepatology. 2022 May 13;: PMID: 32716559. Fráguas-Eggenschwiler M, Eggenschwiler R, Söllner JH, Cortnumme L, Vondran FWR , Cantz T, Ott M, Niemann H. Direct conversion of porcine primary fibroblasts into hepatocyte-like cells. Sci Rep. 2021 Apr 29;11(1):9334. doi: 10.1038/s41598-021-88727-1. PMID: 33927320; PMCID: PMC8085017. Tegtmeyer B, Vieyres G, Todt D, Lauber C, Ginkel C, Engelmann M, Herrmann M, Pfaller CK, Vondran FWR , Broering R, Vafadarnejad E, Saliba AE, Puff C, Baumgärtner W, Miskey C, Ivics Z, Steinmann E, Pietschmann T, Brown RJP. Initial HCV infection of adult hepatocytes triggers a temporally structured transcriptional program containing diverse pro- and anti-viral elements. J Virol. 2021 Apr 26;95(10):e00245-21. doi: 10.1128/JVI.00245-21. Epub 2021 Mar 3. PMID: 33658347; PMCID: PMC8139656. Feldbrügge L , Gronau F , Brandl A, Auer TA, Oeff A, Thuss-Patience P, Pratschke J, Rau B. Systemic Chemotherapy Including Ramucirumab in Combination With Pressurized Intra-Peritoneal Aerosol Chemotherapy Is a Safe Treatment Option for Peritoneal Metastasis of Gastric Cancer. Front Oncol. 2021 Apr 12;10:610572. doi: 10.3389/fonc.2020.610572. PMID: 33912438; PMCID: PMC8074678. Haber PK, Maier C, Kästner A, Feldbrügge L , Ortiz Galindo SA, Geisel D, Fehrenbach U, Biebl M, Krenzien F, Benzing C, Schöning W, Pratschke J, Schmelzle M . Predicting the Risk of Postoperative Complications in Patients Undergoing Minimally Invasive Resection of Primary Liver Tumors. J Clin Med. 2021 Feb 10;10(4):685. doi: 10.3390/jcm10040685. PMID: 33578875; PMCID: PMC7916554. Memaran N, Küpper C, Borchert-Mörlins B, von Wick A, Bauer E, Jäckel E, Maasoumy B, Vondran FWR , Sugianto RI, von der Born J, Schmidt BMW, Melk A. Prospective assessment of subclinical cardiovascular damage and associated factors in liver transplant recipients. Transpl Int. 2021 Jan;34(1):127-138. doi: 10.1111/tri.13773. Epub 2020 Nov 10. PMID: 33070384. Kamali C, Kamali K, Brunnbauer P, Splith K , Pratschke J, Schmelzle M , Krenzien F. Extended liver resection in mice: state of the art and pitfalls-a systematic review. Eur J Med Res. 2021 Jan 9;26(1):6. doi: 10.1186/s40001-020-00478-3. PMID: 33422147; PMCID: PMC7797144. 2020 Knitter S, Andreou A, Kradolfer D, Beierle AS, Pesthy S, Eichelberg AC, Kästner A, Feldbrügge L , Krenzien F, Schulz M, Banz V, Lachenmayer A, Biebl M, Schöning W, Candinas D, Pratschke J, Beldi G, Schmelzle M . Minimal-Invasive Versus Open Hepatectomy for Colorectal Liver Metastases: Bicentric Analysis of Postoperative Outcomes and Long-Term Survival Using Propensity Score Matching Analysis. J Clin Med. 2020 Dec 13;9(12):4027. doi: 10.3390/jcm9124027. PMID: 33322087; PMCID: PMC7764401. Brown RJP, Tegtmeyer B, Sheldon J, Khera T, Anggakusuma, Todt D, Vieyres G, Weller R, Joecks S, Zhang Y, Sake S, Bankwitz D, Welsch K, Ginkel C, Engelmann M, Gerold G, Steinmann E, Yuan Q, Ott M, Vondran FWR , Krey T, Ströh LJ, Miskey C, Ivics Z, Herder V, Baumgärtner W, Lauber C, Seifert M, Tarr AW, McClure CP, Randall G, Baktash Y, Ploss A, Thi VLD, Michailidis E, Saeed M, Verhoye L, Meuleman P, Goedecke N, Wirth D, Rice CM, Pietschmann T. Liver-expressed Cd302 and Cr1l limit hepatitis C virus cross-species transmission to mice. Sci Adv. 2020 Nov 4;6(45):eabd3233. doi: 10.1126/sciadv.abd3233. PMID: 33148654; PMCID: PMC7673688. Beetz O , Weigle CA , Cammann S , Vondran FWR , Timrott K, Kulik U, Bektas H, Klempnauer J, Kleine M, Oldhafer F . Preoperative leukocytosis and the resection severity index are independent risk factors for survival in patients with intrahepatic cholangiocarcinoma. Langenbecks Arch Surg. 2020 Nov;405(7):977-988. doi: 10.1007/s00423-020-01962-4. Epub 2020 Aug 19. PMID: 32815017; PMCID: PMC7541380. Wandrer F, Frangež Ž, Liebig S, John K, Vondran F , Wedemeyer H, Veltmann C, Pfeffer TJ, Shibolet O, Schulze-Osthoff K, Simon HU, Bantel H. Autophagy alleviates amiodarone-induced hepatotoxicity. Arch Toxicol. 2020 Oct;94(10):3527-3539. doi: 10.1007/s00204-020-02837-9. Epub 2020 Jul 10. PMID: 32651653; PMCID: PMC7502042. Ramackers W , Stupak JV, Marcheel IL, Tuffs A, Schrem H, Fischer V, Beneke J. Regression analyses of questionnaires in bedside teaching. BMC Med Educ. 2020 Oct 16;20(1):371. doi: 10.1186/s12909-020-02295-y. PMID: 33081766; PMCID: PMC7574454. Yang D, Dai Z, Yang T, Balakrishnan A, Yuan Q, Vondran FWR , Manns MP, Ott M, Cantz T, Sharma AD. MicroRNA-125b-5p Regulates Hepatocyte Proliferation During the Termination Phase of Liver Regeneration. Hepatol Commun. 2020 Sep 15;4(12):1851-1863. doi: 10.1002/hep4.1597. PMID: 33305155; PMCID: PMC7706294. Stocklassa T, Borchert-Mörlins B, Memaran N, Einecke G, Schmitt R, Richter N, Vondran FW , Bauer E, Markefke S, Melk A, Schmidt BMW. Sex Differences in Subclinical Cardiovascular Organ Damage After Renal Transplantation: A Single-Center Cohort Study. J Womens Health (Larchmt). 2021 Sep;30(9):1352-1361. doi: 10.1089/jwh.2020.8594. Epub 2020 Nov 18. PMID: 33211603. DeTemple DE , Cammann S , Bahlmann J, Buettner M, Heisterkamp A, Vondran FWR , Kalies SK. Longitudinal imaging and femtosecond laser manipulation of the liver: How to generate and trace single-cell-resolved micro-damage in vivo. PLoS One. 2020 Oct 15;15(10):e0240405. doi: 10.1371/journal.pone.0240405. PMID: 33057345; PMCID: PMC7561146. Carpentier A, Sheldon J, Vondran FWR , Brown RJ, Pietschmann T. Efficient acute and chronic infection of stem cell-derived hepatocytes by hepatitis C virus. Gut. 2020 Sep;69(9):1659-1666. doi: 10.1136/gutjnl-2019-319354. Epub 2020 Feb 29. PMID: 32114504; PMCID: PMC7456736. Kinast V, Plociennikowska A, Anggakusuma, Bracht T, Todt D, Brown RJP, Boldanova T, Zhang Y, Brüggemann Y, Friesland M, Engelmann M, Vieyres G, Broering R, Vondran FWR , Heim MH, Sitek B, Bartenschlager R, Pietschmann T, Steinmann E. C19orf66 is an interferon-induced inhibitor of HCV replication that restricts formation of the viral replication organelle. J Hepatol. 2020 Sep;73(3):549-558. doi: 10.1016/j.jhep.2020.03.047. Epub 2020 Apr 12. PMID: 32294532. Stahl K, Busch M, Fuge J, Schneider A, Manns MP, Seeliger B, Schmidt JJ, Wiesner O, Schmidt BMW, Taubert R, Vondran FWR , Hoeper MM, David S. Therapeutic plasma exchange in acute on chronic liver failure. J Clin Apher. 2020 Aug;35(4):316-327. doi: 10.1002/jca.21799. Epub 2020 Jun 24. PMID: 32583446. Nevermann NF , Hillebrandt KH, Knitter S, Ritschl PV, Krenzien F, Benzing C, Bahra M, Biebl M, Sauer IM, Öllinger R, Schöning W, Schmelzle M , Pratschke J; COVID-19 Surgical Oncology Collaboration Group. COVID-19 pandemic: implications on the surgical treatment of gastrointestinal and hepatopancreatobiliary tumours in Europe. Br J Surg. 2020 Aug;107(9):e301-e302. doi: 10.1002/bjs.11751. Epub 2020 Jun 10. PMID: 32521041; PMCID: PMC7300698. Beetz O , Sarisin A, Kaltenborn A, Klempnauer J, Winkler M, Grannas G. Multivisceral resection for adenocarcinoma of the pancreatic body and tail-a retrospective single-center analysis. World J Surg Oncol. 2020 Aug 20;18(1):218. doi: 10.1186/s12957-020-01973-x. PMID: 32819373; PMCID: PMC7441692. Beetz O , Bajunaid A, Meißler L, Vondran FWR , Kleine M, Cammann S , Hanke JS, Schmitto JD, Haverich A, Klempnauer J, Ringe KI, Oldhafer F , Timrott K. Abdominal Surgery in Patients with Ventricular Assist Devices: a Single-Center Report. ASAIO J. 2020 Aug;66(8):890-898. doi: 10.1097/MAT.0000000000001085. PMID: 32740349. Riesner K, Cordes S, Peczynski C, Kalupa M, Schwarz C, Shi Y, Mertlitz S, Mengwasser J, van der Werf S, Peric Z, Koenecke C, Schoemans H, Duarte RF, Basak GW, Penack O. Reduced Calcium Signaling Is Associated With Severe Graft-Versus-Host Disease: Results From Preclinical Models and From a Prospective EBMT Study. Front Immunol. 2020 Aug 11;11:1983. doi: 10.3389/fimmu.2020.01983. PMID: 32849661; PMCID: PMC7431962. Feldbrügge L , Splith K , Kämmerer I, Richter S, Riddermann A, Ortiz Galindo SA, Krenzien F, Müller T, Csizmadia E, Pratschke J, Robson SC, Schmelzle M . Ecto-Nucleotide Triphosphate Diphosphohydrolase-2 (NTPDase2) Deletion Increases Acetaminophen-Induced Hepatotoxicity. Int J Mol Sci. 2020 Aug 20;21(17):5998. doi: 10.3390/ijms21175998. PMID: 32825435; PMCID: PMC7504458. Feldbrügge L , Wabitsch S, Benzing C, Krenzien F, Kästner A, Haber PK, Atanasov G, Andreou A, Öllinger R, Pratschke J, Schmelzle M . Safety and feasibility of laparoscopic liver resection in patients with a history of abdominal surgeries. HPB (Oxford). 2020 Aug;22(8):1191-1196. doi: 10.1016/j.hpb.2019.11.006. Epub 2019 Dec 9. PMID: 31831317. Oldhafer F , Wittauer EM, Beetz O , Vondran FWR . Long-term Functional Maintenance of Exteriorized Portal Venous Catheters in a Porcine Animal Model. J Surg Res. 2020 Jul;251:187-194. doi: 10.1016/j.jss.2020.02.003. Epub 2020 Mar 9. PMID: 32163793. Ritschl PV, Nevermann N , Wiering L, Wu HH, Moroder P, Brandl A, Hillebrandt K, Tacke F, Friedersdorff F, Schlomm T, Schöning W, Öllinger R, Schmelzle M , Pratschke J. Solid organ transplantation programs facing lack of empiric evidence in the COVID-19 pandemic: A By-proxy Society Recommendation Consensus approach. Am J Transplant. 2020 Jul;20(7):1826-1836. doi: 10.1111/ajt.15933. Epub 2020 May 10. PMID: 32323460; PMCID: PMC7264649. Sellau J, Groneberg M, Fehling H, Thye T, Hoenow S, Marggraff C, Weskamm M, Hansen C, Stanelle-Bertram S, Kuehl S, Noll J, Wolf V , Metwally NG, Hagen SH, Dorn C, Wernecke J, Ittrich H, Tannich E, Jacobs T, Bruchhaus I, Altfeld M, Lotter H. Androgens predispose males to monocyte-mediated immunopathology by inducing the expression of leukocyte recruitment factor CXCL1. Nat Commun. 2020 Jul 10;11(1):3459. doi: 10.1038/s41467-020-17260-y. PMID: 32651360; PMCID: PMC7351718. Vieyres G, Reichert I, Carpentier A, Vondran FWR , Pietschmann T. The ATGL lipase cooperates with ABHD5 to mobilize lipids for hepatitis C virus assembly. PLoS Pathog. 2020 Jun 15;16(6):e1008554. doi: 10.1371/journal.ppat.1008554. PMID: 32542055; PMCID: PMC7316345. Bahlmann J, Madrahimov N, Daniel F, Theidel D, DeTemple DE , Buettner M, Bleich A, Haverich A, Heisterkamp A, Kalies S. Establishment of a guided, in vivo, multi-channel, abdominal, tissue imaging approach. Sci Rep. 2020 Jun 8;10(1):9224. doi: 10.1038/s41598-020-65950-w. PMID: 32513950; PMCID: PMC7280182. Lauterbach-Rivière L, Bergez M, Mönch S, Qu B, Riess M, Vondran FWR , Liese J, Hornung V, Urban S, König R. Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes. Viruses. 2020 May 29;12(6):592. doi: 10.3390/v12060592. PMID: 32485908; PMCID: PMC7354540. Krenzien F, Katou S, Papa A, Sinn B, Benzing C, Feldbrügge L , Kamali C, Brunnbauer P, Splith K , Lorenz RR , Ritschl P, Wiering L, Öllinger R, Schöning W, Pratschke J, Schmelzle M . Increased Cell-Free DNA Plasma Concentration Following Liver Transplantation Is Linked to Portal Hepatitis and Inferior Survival. J Clin Med. 2020 May 20;9(5):1543. doi: 10.3390/jcm9051543. PMID: 32443763; PMCID: PMC7291032. Carvalho Oliveira M, Valdivia E, Verboom M, Yuzefovych Y, Sake HJ, Pogozhykh O, Niemann H, Schwinzer R , Petersen B, Seissler J, Blasczyk R, Figueiredo C. Generating low immunogenic pig pancreatic islet cell clusters for xenotransplantation. J Cell Mol Med. 2020 May;24(9):5070-5081. doi: 10.1111/jcmm.15136. Epub 2020 Mar 25. PMID: 32212307; PMCID: PMC7205796. Timrott K, Beetz O, Oldhafer F , Klempnauer J, Vondran FWR , Jäger MD. The importance of MHC class II in allogeneic bone marrow transplantation and chimerism-based solid organ tolerance in a rat model. PLoS One. 2020 May 22;15(5):e0233497. doi: 10.1371/journal.pone.0233497. PMID: 32442182; PMCID: PMC7244129. Weigle CA , Lieke T, Vondran FWR , Timrott K, Klempnauer J, Beetz O . An Immunological Model for Heterotopic Heart and Cardiac Muscle Cell Transplantation in Rats. J Vis Exp. 2020 May 8;(159). doi: 10.3791/60956. PMID: 32449721. Wiesener A, Knaup KX, Büttner-Herold M, Dieterle A, Stoeckert J, Riedl B, Morath C, Wald A, Vondran F , Braun F, Schödel J, Schueler M, Schiffer M, Amann K, Reis A, Kraus C, Wiesener MS. Molecular diagnosis of kidney transplant failure based on urine. Am J Transplant. 2020 May;20(5):1410-1416. doi: 10.1111/ajt.15738. Epub 2020 Jan 20. PMID: 31814324. Hein R, Sake HJ, Pokoyski C , Hundrieser J, Brinkmann A , Baars W , Nowak-Imialek M, Lucas-Hahn A, Figueiredo C, Schuberth HJ, Niemann H, Petersen B, Schwinzer R . Triple (GGTA1, CMAH, B2M) modified pigs expressing an SLA class Ilow phenotype-Effects on immune status and susceptibility to human immune responses. Am J Transplant. 2020 Apr;20(4):988-998. doi: 10.1111/ajt.15710. Epub 2019 Dec 28. PMID: 31733031. Sneidere M, Schrem HH, Mahlmann JC, Beetz O , Cammann S , Oldhafer F , Kleine M, Klempnauer J, Kaltenborn A, Zwirner U, Kulik U. Proposal of a Multivariable Prediction Model for Graded Morbidity after Liver Resection for Colorectal Metastases. Zentralbl Chir. 2023 Apr;148(2):147-155. English. doi: 10.1055/a-1243-0746. Epub 2020 Oct 22. PMID: 33091938. Ramackers W , Rataj D, Werwitzke S, Bergmann S, Winkler M, Wünsch A, Bähr A, Wolf E, Klymiuk N, Ayares D, Tiede A. Expression of human thrombomodulin on porcine endothelial cells can reduce platelet aggregation but did not reduce activation of complement or endothelium - an experimental study. Transpl Int. 2020 Apr;33(4):437-449. doi: 10.1111/tri.13573. Epub 2020 Feb 9. PMID: 31926034. Bojkova D, Westhaus S, Costa R, Timmer L, Funkenberg N, Korencak M, Streeck H, Vondran F , Broering R, Heinrichs S, Lang KS, Ciesek S. Sofosbuvir Activates EGFR-Dependent Pathways in Hepatoma Cells with Implications for Liver-Related Pathological Processes. Cells. 2020 Apr 17;9(4):1003. doi: 10.3390/cells9041003. PMID: 32316635; PMCID: PMC7225999. Beetz O , Weigle CA , Nogly R, Klempnauer J, Pape L, Richter N, Vondran FWR . Surgical complications in pediatric kidney transplantation-Incidence, risk factors, and effects on graft survival: A retrospective single-center study. Pediatr Transplant. 2021 Mar;25(2):e13871. doi: 10.1111/petr.13871. Epub 2020 Oct 14. PMID: 33053269. Hruby J, Spunda R, Mericka P, Mlcek M, Pecha O, Splith K , Schmelzle M , Krenzien F, Lindner J, Spacek M, Matia I. Influence of the new standardized clinical cryopreservation/slow thawing protocol on immunogenicity of arterial allografts in rats. PLoS One. 2020 Mar 10;15(3):e0230234. doi: 10.1371/journal.pone.0230234. PMID: 32155226; PMCID: PMC7064217. Beetz O , Söffker R, Cammann S , Oldhafer F , Vondran FWR , Imkamp F, Klempnauer J, Kleine M. Extended hepatic metastasectomy for renal cell carcinoma-new aspects in times of targeted therapy: a single-center experience over three decades. Langenbecks Arch Surg. 2020 Feb;405(1):97-106. doi: 10.1007/s00423-019-01852-4. Epub 2020 Jan 14. PMID: 31938833; PMCID: PMC7036059. Fischer K, Rieblinger B, Hein R, Sfriso R, Zuber J, Fischer A, Klinger B, Liang W, Flisikowski K, Kurome M, Zakhartchenko V, Kessler B, Wolf E, Rieben R, Schwinzer R , Kind A, Schnieke A. Viable pigs after simultaneous inactivation of porcine MHC class I and three xenoreactive antigen genes GGTA1, CMAH and B4GALNT2. Xenotransplantation. 2020 Jan;27(1):e12560. doi: 10.1111/xen.12560. Epub 2019 Oct 8. PMID: 31591751. Todt D, Friesland M, Moeller N, Praditya D, Kinast V, Brüggemann Y, Knegendorf L, Burkard T, Steinmann J, Burm R, Verhoye L, Wahid A, Meister TL, Engelmann M, Pfankuche VM, Puff C, Vondran FWR , Baumgärtner W, Meuleman P, Behrendt P, Steinmann E. Robust hepatitis E virus infection and transcriptional response in human hepatocytes. Proc Natl Acad Sci U S A. 2020 Jan 21;117(3):1731-1741. doi: 10.1073/pnas.1912307117. Epub 2020 Jan 2. PMID: 31896581; PMCID: PMC6983376. 2019 Ko C, Bester R, Zhou X, Xu Z, Blossey C, Sacherl J, Vondran FWR , Gao L, Protzer U. A New Role for Capsid Assembly Modulators To Target Mature Hepatitis B Virus Capsids and Prevent Virus Infection. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01440-19. doi: 10.1128/AAC.01440-19. PMID: 31658963; PMCID: PMC7187577. Sake HJ, Frenzel A, Lucas-Hahn A, Nowak-Imialek M, Hassel P, Hadeler KG, Hermann D, Becker R, Eylers H, Hein R, Baars W , Brinkmann A , Schwinzer R , Niemann H, Petersen B. Possible detrimental effects of beta-2-microglobulin knockout in pigs. Xenotransplantation. 2019 Nov;26(6):e12525. doi: 10.1111/xen.12525. Epub 2019 May 22. PMID: 31119817. Rothweiler S, Feldbrügge L , Jiang ZG, Csizmadia E, Longhi MS, Vaid K, Enjyoji K, Popov YV, Robson SC. Selective deletion of ENTPD1/CD39 in macrophages exacerbates biliary fibrosis in a mouse model of sclerosing cholangitis. Purinergic Signal. 2019 Sep;15(3):375-385. doi: 10.1007/s11302-019-09664-3. Epub 2019 Jun 26. PMID: 31243614; PMCID: PMC6737175. Echtermeyer F, Eberhardt M, Risser L, Herzog C, Gueler F, Khalil M, Engel M, Vondran F, Leffler A. Acetaminophen-induced liver injury is mediated by the ion channel TRPV4. FASEB J. 2019 Sep;33(9):10257-10268. doi: 10.1096/fj.201802233R. Epub 2019 Jun 17. PMID: 31207191. Oldhafer F , Ringe KI, Timrott K, Kleine M, Beetz O , Ramackers W , Cammann S , Klempnauer J, Bektas H, Vondran FWR . Response to "Critical appraisal of the modified ante situm liver resection-is the original method the better choice?". Langenbecks Arch Surg. 2019 Aug;404(5):649-651. doi: 10.1007/s00423-019-01795-w. Epub 2019 Jun 29. PMID: 31256253. Beetz O , Kolb J, Buck B, Trautewig B , Timrott K, Vondran FWR , Meder I , Löbbert C , Hundrieser J, Klempnauer J, Bektaş H, Lieke T. Recipient natural killer cells alter the course of rejection of allogeneic heart grafts in rats. PLoS One. 2019 Aug 22;14(8):e0220546. doi: 10.1371/journal.pone.0220546. PMID: 31437165; PMCID: PMC6705777. Oldhafer F , Wittauer EM, Falk CS, DeTemple DE , Beetz O , Timrott K, Kleine M, Vondran FWR . Alloresponses of Mixed Lymphocyte Hepatocyte Culture to Immunosuppressive Drugs as an In-Vitro Model of Hepatocyte Transplantation. Ann Transplant. 2019 Aug 13;24:472-480. doi: 10.12659/AOT.915982. PMID: 31406101; PMCID: PMC6705178. Figueiredo C, Oldhafer F, Wittauer EM, Carvalho-Oliveira M, Akhdar A, Beetz O , Chen-Wacker C, Yuzefovych Y, Falk CS, Blasczyk R, Vondran FWR . Silencing of HLA class I on primary human hepatocytes as a novel strategy for reduction in alloreactivity. J Cell Mol Med. 2019 Aug;23(8):5705-5714. doi: 10.1111/jcmm.14484. Epub 2019 Jun 10. PMID: 31180181; PMCID: PMC6653539. Hundrieser J, Hein R, Pokoyski C , Brinkmann A , Düvel H, Dinkel A , Trautewig B , Siegert JF, Römermann D, Petersen B, Schwinzer R. Role of human and porcine MHC DRB1 alleles in determining the intensity of individual human anti-pig T-cell responses. Xenotransplantation. 2019 Jul;26(4):e12523. doi: 10.1111/xen.12523. Epub 2019 May 9. PMID: 31074044. Wabitsch S, Benzing C, Krenzien F, Splith K , Haber PK, Arnold A, Nösser M, Kamali C, Hermann F, Günther C, Hirsch D, Sauer IM, Pratschke J, Schmelzle M . Human Stem Cells Promote Liver Regeneration After Partial Hepatectomy in BALB/C Nude Mice. J Surg Res. 2019 Jul;239:191-200. doi: 10.1016/j.jss.2019.02.010. Epub 2019 Mar 4. PMID: 30844633. Kinast V, Leber SL, Brown RJP, Vieyres G, Behrendt P, Eßbach C, Strnad P, Vondran FWR , Cornberg M, Wex C, Pietschmann T, Haybaeck J, Todt D, Steinmann E. Identification of Keratin 23 as a Hepatitis C Virus-Induced Host Factor in the Human Liver. Cells. 2019 Jun 18;8(6):610. doi: 10.3390/cells8060610. PMID: 31216713; PMCID: PMC6628310. Stockmann M, Vondran FWR , Fahrner R, Tautenhahn HM, Mittler J, Bektas H, Malinowski M, Jara M, Klein I, Lock JF; Collaborative Fast‐track Liver Study Group. Randomized clinical trial comparing liver resection with and without perioperative assessment of liver function. BJS Open. 2018 Jun 14;2(5):301-309. doi: 10.1002/bjs5.81. PMID: 30263981; PMCID: PMC6156169. Wabitsch S, Kästner A, Haber PK, Feldbrügge L , Winklmann T, Werner S, Pratschke J, Schmelzle M . Laparoscopic versus open hemihepatectomy-a cost analysis after propensity score matching. Langenbecks Arch Surg. 2019 Jun;404(4):469-475. doi: 10.1007/s00423-019-01790-1. Epub 2019 May 7. PMID: 31065781. Ramackers W , Werwitzke S, Klose J, Friedrich L, Johanning K, Bergmann S, Klempnauer J, Winkler M, Tiede A. Investigation of the influence of xenoreactive antibodies on activation of complement and coagulation in an ex vivo perfusion animal study using porcine kidneys. Transpl Int. 2019 May;32(5):546-556. doi: 10.1111/tri.13396. Epub 2019 Jan 22. PMID: 30597634. Schwager Y, Littbarski SA, Nolte A, Kaltenborn A, Emmanouilidis N, Kleine-Döpke D , Klempnauer J, Schrem H. Prediction of Three-Year Mortality After Deceased Donor Kidney Transplantation in Adults with Pre-Transplant Donor and Recipient Variables. Ann Transplant. 2019 May 17;24:273-290. doi: 10.12659/AOT.913217. PMID: 31097680; PMCID: PMC6540619. Wittauer EM, Oldhafer F , Augstein E, Beetz O, Kleine M, Schumacher C, Sieg L, Eismann H, Johanning K, Bleich A, Vondran FWR . Porcine model for the study of liver regeneration enhanced by non-invasive 13C-methacetin breath test (LiMAx test) and permanent portal venous access. PLoS One. 2019 May 31;14(5):e0217488. doi: 10.1371/journal.pone.0217488. PMID: 31150446; PMCID: PMC6544243. Winkelmann M, Butz AL, Clausen JD, Blossey RD , Zeckey C, Weber-Spickschen S, Mommsen P. Admission blood glucose as a predictor of shock and mortality in multiply injured patients. SICOT J. 2019;5:17. doi: 10.1051/sicotj/2019015. Epub 2019 May 28. PMID: 31134892; PMCID: PMC6538364. Strowitzki MJ, Radhakrishnan P, Pavicevic S, Scheer J, Kimmer G, Ritter AS, Tuffs C, Volz C, Vondran F , Harnoss JM, Klose J, Schmidt T, Schneider M. High hepatic expression of PDK4 improves survival upon multimodal treatment of colorectal liver metastases. Br J Cancer. 2019 Apr;120(7):675-688. doi: 10.1038/s41416-019-0406-9. Epub 2019 Feb 27. PMID: 30808993; PMCID: PMC6461828. Krenzien F, Keshi E, Splith K , Griesel S, Kamali K, Sauer IM, Feldbrügge L , Pratschke J, Leder A, Schmelzle M . Diagnostic Biomarkers to Diagnose Acute Allograft Rejection After Liver Transplantation: Systematic Review and Meta-Analysis of Diagnostic Accuracy Studies. Front Immunol. 2019 Apr 11;10:758. doi: 10.3389/fimmu.2019.00758. PMID: 31031758; PMCID: PMC6470197. Tsay HC, Yuan Q, Balakrishnan A, Kaiser M, Möbus S, Kozdrowska E, Farid M, Tegtmeyer PK, Borst K, Vondran FWR , Kalinke U, Kispert A, Manns MP, Ott M, Sharma AD. Hepatocyte-specific suppression of microRNA-221-3p mitigates liver fibrosis. J Hepatol. 2019 Apr;70(4):722-734. doi: 10.1016/j.jhep.2018.12.016. Epub 2018 Dec 22. Erratum in: J Hepatol. 2022 Jul;77(1):269. PMID: 30582979. Schumacher C, Eismann H, Sieg L, Friedrich L, Scheinichen D, Vondran FWR , Johanning K. Use of Rotational Thromboelastometry in Liver Transplantation Is Associated With Reduced Transfusion Requirements. Exp Clin Transplant. 2019 Apr;17(2):222-230. doi: 10.6002/ect.2017.0236. Epub 2018 Oct 5. PMID: 30295585. Wiltberger G, Wu Y, Lange U, Hau HM, Tapper E, Krenzien F, Atanasov G, Benzing C, Feldbrügge L , Csizmadia E, Broschewitz J, Bartels M, Seehofer D, Jonas S, Berg T, Hessel P, Ascherl R, Neumann UP, Pratschke J, Robson SC, Schmelzle M . Protective effects of coffee consumption following liver transplantation for hepatocellular carcinoma in cirrhosis. Aliment Pharmacol Ther. 2019 Mar;49(6):779-788. doi: 10.1111/apt.15089. PMID: 30811647. Mederacke YS, Vondran FW , Kollrich S, Schulde E, Schmitt R, Manns MP, Klempnauer J, Schwinzer R , Noyan F, Jaeckel E. Transient increase of activated regulatory T cells early after kidney transplantation. Sci Rep. 2019 Jan 31;9(1):1021. doi: 10.1038/s41598-018-37218-x. PMID: 30705299; PMCID: PMC6355855 back

Treatment of Late Antibody-Mediated Kidney Graft Rejection Case Rep Nephrol 2018;2018:1415450 Hirschberg I, Kahrass H. Annual Meeting of the AEM 2017: Good Medicine. Contribution of ethics to the discussion

Publications of the Institute since 1997 2026 Polten,Felix ; Sandu,Mircea-Andrei ; Faix,Jan ; Hegermann,Jan ; Kriedemann,Nils ; Zweigerdt,Robert ; Thum,Thomas ; Bauersachs,Johann ; Niessen,Hans W. ; Koenig,Andrew L. ; Lavine,Kory J. ; Pich,Andreas ; Wang,Yong ; Reboll,Marc R. ; Korf-Klingebiel,Mortimer ; Wollert,Kai C. ; Extracellular BRICK1 drives heart repair after myocardial infarction in mice, United States,Sci.Transl.Med.,2026;18(831):eadx2876 Originalpublikation 2025 Bai,Yiling ; Wu,Zhaojia ; Leary,Scot C. ; Fang,Chen ; Yu,Michelle ; Genth,Harald ; Xie,Yufeng ; Shi,Jinhui ; Xiang,Jim ; Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways, Switzerland,Int.J.Mol.Sci.,2025;26(4):1669 Originalpublikation Bellmann,Denise ; Evaluation of the neutralizing activity of newly developed equine antibodies against C. botulinum neurotoxins using in vitro differentiated P19 neurons, Hannover,,2025;() Masterarbeit Bollenbach,Alexander ; Beckmann,Bibiana ; Tsikas,Dimitrios ; Quality control in GC-MS analysis of amino acids in human urine and plasma: Possible implications for targeted and untargeted metabolomics, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1262():124661 Originalpublikation Bünermann,Ines ; Detering,Nora ; Tapken,Ines ; Kuhn,Daniela ; Jahn,Kirsten ; Burkert,Alexandra ; Naczinsky,Sarah ; Hensel,Niko ; Schüning,Tobias ; Dittrich-Breiholz,Oliver ; Pich,Andreas ; Claus,Peter ; Alterations along the neuroendocrine axis of leptin homeostasis: white adipose tissue and hypothalamus in a severe SMA mouse model, England,Hum.Mol.Genet.,2025;():- Originalpublikation Chung,Bomee ; Jonas,Wenke ; Rostami,Fatemeh ; Malik,Zulaikha ; Szaroszyk,Malgorzata ; Levay,Magdolna ; Thackeray,James ; Ost,Mario ; Nowak,Steven ; Hegermann,Jan ; Wieland,Thomas ; Pich,Andreas ; Bengel,Frank M. ; Bauersachs,Johann ; Wollert,Kai C. ; Heineke,Joerg ; Schürmann,Annette ; Kempf,Tibor Iron regulatory proteins secure iron availability in skeletal muscle to preserve exercise tolerance in heart failure England,Cardiovasc.Res.,2025;() Originalpublikation Chung,Soo-Young ; Die Bedeutung konservierter Cysteine für die Funktion der Clostridium difficile Toxine A und B, Hannover,,2024;():4 ungezählte Blätter, 45 Blätter Dissertation Dastagir,Nadjib ; Liebsch,Christina ; Kutz,Jaqueline ; Wronski,Sabine ; Pich,Andreas ; Obed,Doha ; Vogt,Peter Maria ; Bucan,Vesna ; Strauß,Sarah ; Identification of antimicrobial peptides from the Ambystoma mexicanum displaying antibacterial and antitumor activity, United States,PLoS One,2025;20(3):-e0316257 Originalpublikation Dettmann,Paulin ; Skiba,Martin ; Stern,Daniel ; Weisemann,Jasmin ; Mages,Hans Werner ; Krez,Nadja ; Dorner,Martin B. ; Schaarschmidt,Sara ; Avondet,Marc A. ; Fulde,Marcus ; Rummel,Andreas ; Strommenger,Birgit ; Maurischat,Sven ; Dorner,Brigitte G. ; Highly Sensitive Suspension Immunoassay for Multiplex Detection, Differentiation, and Quantification of Eight Staphylococcus aureus Enterotoxins (SEA to SEI), Switzerland,Toxins (Basel),2025;17(6):265-http://doi.org/10.3390/toxins17060265 Originalpublikation Dietz-Ziegler,Stefanie ; Kewitz,Samantha ; Kaiser,Gabriele ; Rühle,Jessica ; Marmé,Alexander ; Dalpke,Alexander ; Cheaib,Bachar ; Pauluschke-Fröhlich,Jan ; Henes,Melanie ; Velic,Ana ; Pich,Andreas ; Vollert,Anneli ; Schaller,Martin ; Knab,Felix ; Lajqi,Trim ; Poets,Christian F. ; Gille,Christian ; Köstlin-Gille,Natascha Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy-Supportive Phenotype In Vitro, Germany,Eur.J.Immunol.,2025;55(9):e70056 Originalpublikation Frommeyer,Yannick N. ; Gomez,Nicolas O. ; Preusse,Matthias ; Arce-Rodriguez,Alejandro ; Neubauer,Kerstin ; Kennepohl,Benedikt ; Witte,Julius ; Bouheraoua,Safaa ; Cetraro,Pierina ; Erdmann,Jelena ; Neumann-Schaal,Meina ; Müsken,Mathias ; Pich,Andreas ; Bähre,Heike ; Depledge,Daniel P. ; Häussler,Susanne ; tRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity, England,Nucleic Acids Res.,2025;53(14):gkaf719 Originalpublikation Gand,Luis Vincens ; Lanzuolo,Chiara ; Li,Mugeng ; Rosti,Valentina ; Weber,Natalie ; Lu,Dongchao ; Bär,Christian ; Thum,Thomas ; Pich,Andreas ; Kraft,Theresia ; Amrute-Nayak,Mamta ; Nayak,Arnab ; Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine-Induced Cachexia, Germany,J.Cachexia Sarcopenia Muscle,2025;16(2):-e13776 Originalpublikation Gao,Linfeng ; Nowakowska,Maria Barbara ; Selby,Katja ; Przykopanski,Adina ; Chen,Baohua ; Krüger,Maren ; Douillard,François Paul ; Lam,Kwok-Ho ; Chen,Peng ; Huang,Ting ; Minton,Nigel Peter ; Dorner,Martin Bernhard ; Dorner,Brigitte Gertrud ; Rummel,Andreas ; Lindström,Miia ; Jin,Rongsheng ; Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47, United States,Nat.Struct.Mol.Biol.,2025;():- Originalpublikation Hage,David S. ; Liu,Huwei ; Theodoridis,Georgios ; Tsikas,Dimitrios ; Virgilliou,Christina ; Wilson,Ian ; Chemical analysis-relating nomenclature issues in the Journal of Chromatography B, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1263():124703 Originalpublikation Heimerl,Maren ; Erschow,Sergej ; Müller-Olling,Mirco ; Manstein,Dietmar J. ; Decher,Niels ; Kauferstein,Silke ; Jenewein,Tina ; Pich,Andreas ; Ricke-Hoch,Melanie ; Hilfiker-Kleiner,Denise ; Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression, England,Eur.Heart J.,2025;(): Originalpublikation Horn,Vanessa ; Zarnovican,Patricia ; Tiemann,Birgit ; Pich,Andreas ; Bakker,Hans ; Routier,Françoise H. ; N-Glycoproteomics of the Apicomplexan Parasite Toxoplasma gondii, Germany,,2025;():-e202400239 Originalpublikation Ibrahim,Nurul Khalida ; Schreek,Sabine ; Cinar,Buesra ; Stasche,Anna Sophie ; Lee,Su Hyun ; Zeug,Andre ; Dolgner,Tim ; Niessen,Julia ; Ponimaskin,Evgeni ; Shcherbata,Halyna ; Fehlhaber,Beate ; Bourquin,Jean-Pierre ; Bornhauser,Beat ; Stanulla,Martin ; Pich,Andreas ; Gutierrez,Alejandro ; Hinze,Laura ; SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response, United States,Cell.Rep.,2025;44(4): Originalpublikation Jordan,Maria ; Schmidt,Kevin ; Fuchs,Maximilian ; Just,Annette ; Pfanne,Angelika ; Willmer,Lena ; Neubert,Lavinia ; Werlein,Christopher ; Zardo,Patrick ; Pich,Andreas ; Thum,Thomas ; Fiedler,Jan ; Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung, Switzerland,Front.Pharmacol.,2025;16():1534989 Originalpublikation Josuran,Roland ; Wenger,Andreas ; Worbs,Sylvia ; Kampa,Bettina ; Rummel,Andreas ; Dorner,Brigitte G. ; Gerber,Sabina ; N-Glycosylation Profile of Abrin Certified EU Reference Material, Switzerland,Toxins (Basel),2025;17(3):108 Originalpublikation Kaiser,Annette ; Agostinelli,Enzo ; Tsikas,Dimitrios The hypusine pathway in Ixodes ricinus: molecular cloning and validation of deoxyhypusine synthase as a novel target for drug discovery to treat and prevent vector borne diseases Switzerland,Front.Cell.Infect.Microbiol.,2025;15():1638906 Originalpublikation Kroh,Amelie ; Charakterisierung der nichttoxischen OrfX-Proteine 1-3 sowie P47 aus Clostridium botulinum Serotyp E Subtyp E1 Stamm Beluga, Hannover,,2024;():XII, 154 Blätter, Blatt XIII-XX : Illustrationen, Diagramme Dissertation Lam,Kwok-Ho ; Gao,Linfeng ; Przykopanski,Adina ; Chen,Baohua ; Huang,Ting ; Krüger,Maren ; Bartels,Anna-Magdalena ; Dorner,Martin Bernhard ; Perry,Kay ; Dorner,Brigitte Gertrud ; Rummel,Andreas ; Jin,Rongsheng ; A nut-and-bolt assembly of the bimodular large progenitor botulinum neurotoxin complex, United States,Sci.Adv.,2025;11(35):eadx5831 Originalpublikation Masuyer,Geoffrey ; Rummel,Andreas ; Stenmark,Pål ; Botulinum neurotoxin A mutants with enhanced ganglioside binding show improved potency and altered ganglioside selectivity, England,Commun.Chem.,2025;8(1):171 Originalpublikation Ostermann,Lena ; Seeliger,Benjamin ; Peukert,Konrad ; Steinmetz,Lara-Kristin ; Flasche,Carolin ; Maus,Regina ; Stolper,Jennifer ; Vogl,Thomas ; Pich,Andreas ; Bode,Christian ; Neumann,Konstantin ; Brand,Korbinian ; Tessier,Philippe A. ; Roth,Johannes ; Maus,Ulrich A. ; Lack of S100A8 impairs lung protective immunity against Streptococcus pneumoniae, United States,J.Infect.Dis.,2025;() Originalpublikation Paulmann,Volker ; Mikuteit,Marie ; Just,Ingo ; Karmann,Naomi ; Steffens,Sandra ; The science module in the MHH's model curriculum - development, implementation, results, Germany,GMS J.Med.Educ.,2025;42(5):Doc59 Originalpublikation Ramachandran,Dhanya ; Dewender,Robin Tarek ; Schröder-Heurich,Bianca ; Froböse,Wiebke ; Avdulahu,Florian ; Richter,Katja ; Baker,Valerie L. ; Winn,Virginia D. ; Pich,Andreas ; von Versen-Höynck,Frauke Exploring the plasma proteome linked to corpus luteum presence and conception mode across pregnancy stages and postpartum Netherlands,J.Assist.Reprod.Genet.,2025 Originalpublikation Schmidt,Arne ; Schmidt,Kevin ; Groß,Sonja ; Lu,Dongchao ; Xiao,Ke ; Neufeldt,Dimyana ; Cushman,Sarah ; Lehmann,Nele ; Thum,Sabrina ; Pfanne,Angelika ; Just,Annette ; Pich,Andreas ; Heinz,Alexander ; Hiller,Karsten ; Hunkler,Hannah Jill ; Tan,Wilson Lek Wen ; Foo,Roger ; Bär,Christian ; Thum,Thomas ; Jung,Mira ; Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism, England,Sci.Rep.,2025;15(1):20331 Originalpublikation Smandzich,Nadine J. ; Pich,Andreas ; Gschwendtberger,Thomas ; Greten,Stephan ; Ye,Lan ; Klietz,Martin ; Di Fonzo,Alessio ; Henkel,Lisa M. ; Wegner,Florian Proteomics of Patient-Derived Striatal Medium Spiny Neurons in Multiple System Atrophy Switzerland,,2025;14(17):1394 Originalpublikation Steinberg,Maximilian ; Wilk,Laura-Varenne ; Stern,Daniel ; Weisemann,Jasmin ; Messelhäußer,Ute ; Wittwer,Matthias ; Krüger,Maren ; Mages,Hans Werner ; Rummel,Andreas ; Dorner,Martin B. ; Dorner,Brigitte G. ; Validation of an Endopep-suspension immunoassay for the diagnostics of human botulism, Germany,ALTEX,2025;(): Originalpublikation Tammen,Harald ; Pich,Andreas ; Hess,Rüdiger ; Lechowicz,Urszula ; Janciauskiene,Sabina ; Chorostowska,Joanna ; Quantitative mass spectrometric analysis of C-terminal 36 amino acid peptides of alpha-1 antitrypsin in plasma using survey spectra, United States,Methods,2025;240():7-13 Originalpublikation Tsikas,Dimitrios ; Analysis of eicosanoids by quadrupole gas chromatography-negative ion chemical ionization-tandem mass spectrometry as pentafluorobenzyl trimethylsilyl derivatives: Naming the Murphy rearrangement Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1267():124794 Übersicht Tsikas,Dimitrios ; Analysis, biology and significance of dimethylamine, trimethylamine and trimethylamine N-oxide in humans and in the marine ecosystem, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1258():124602 Originalpublikation Tsikas,Dimitrios ; Assessment of matrix effects in quantitative GC-MS by using isotopologs, United States,Anal.Biochem.,2025;705():115928 Originalpublikation Tsikas,Dimitrios ; Interpretation of negative-ion chemical ionization GC-MS and GC-MS/MS mass spectra of perfluorinated organic analyte derivatives: Consideration of reduction reactions in the gas phase, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1253():124487 Originalpublikation Tsikas,Dimitrios ; Pentafluorobenzyl bromide - A versatile derivatization agent in chromatography and mass spectrometry: II. Analysis of organic acids and bases, and comparison with other perfluorinated reagents, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1257():124578 Originalpublikation Tsikas,Dimitrios ; Proposal and application of nitrogen rules in interpreting gas chromatography negative-ion chemical ionization mass spectrometry spectra, United States,Anal.Biochem.,2025;705():115922 Originalpublikation Tsikas,Dimitrios ; Quantitative GC-MS/MS in the clinical analysis of eicosanoids: A critical review and discussion, a 40-years historical retrospect, and possible implications for LC-MS/MS, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1270():124911 Originalpublikation Tsikas,Dimitrios ; Quantitative GC-NICI-MS and GC-NICI-MS/MS analysis by using isotopologs as internal standards: A tutorial review, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1262():124648 Originalpublikation Tsikas,Dimitrios ; Underlying Mechanisms of Chromatographic H/D, H/F, cis/trans and Isomerism Effects in GC-MS, Switzerland,,2025;15(1):43- Originalpublikation Tsikas,Dimitrios S . ; Tsikas,Stefanos A. ; Collision-Induced Gas-Phase Reactions of PFB-TMS Derivatives of F(2)-Prostaglandins in Quadrupole GC-NICI-MS/MS: A Mini-Review and a Meta-Analysis, Switzerland,Molecules,2025;30(19):3846- Originalpublikation Ückert,Stefan ; Hedlund,Petter ; Tsikas,Dimitrios ; Kuczyk,Markus A. ; The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract, Germany,World J.Urol.,2025;44(1):26 Originalpublikation Wolter,Sabine ; Neumann,Martin ; Koenig,Theresa ; Hagedorn,Tina ; Schwede,Frank ; Pich,Andreas ; Seifert,Roland Identification of cCMP- and cUMP-binding proteins using cCMP and cUMP coupled to agarose and biotin matrices, United States,PLoS One,2025;20(10):e0333904- Originalpublikation 2024 Abbas,Naisam ; Bentele,Marco ; Waleczek,Florian J. G. ; Fuchs,Maximilian ; Just,Annette ; Pfanne,Angelika ; Pich,Andreas ; Linke,Sophie ; Neumüller,Susanne ; Stucki-Koch,Angelika ; Jordan,Maria ; Perbellini,Filippo ; Werlein,Christopher ; Korte,Wilhelm ; Ius,Fabio ; Ruhparwar,Arjang ; Weber,Natalie ; Fiedler,Jan ; Thum,Thomas ; Ex vivo modeling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine J.Mol.Cell.Cardiol, 2024, 196(), 125- 140, Original publication Abbas,Naisam ; Haas,Jonas A. ; Xiao,Ke ; Fuchs,Maximilian ; Just,Annette ; Pich,Andreas ; Perbellini,Filippo ; Werlein,Christopher ; Ius,Fabio ; Ruhparwar,Arjang ; Fiedler,Jan ; Weber,Natalie ; Thum,Thomas ; Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo Eur.Heart J., 2024, 45(22), 2016- 2018, Original publication Albers,Marco Darius ; Tiemann,Birgit ; Kaynert,Jonas Till ; Pich,Andreas ; Bakker, Hans ; Conserved cysteines prevent C-mannosylation of mucin Cys domains, England, FEBS J., 2024; 291(15):3539-3552 Original publication Baskal,Svetlana ; Posma, Rene A. ; Bollenbach, Alexander ; Dieperink, Willem ; Bakker, Stephan J. L. ; Nijsten, Maarten W. ; Touw, Daan J. ; Tsikas, Dimitrios ; GC-MS analysis of 4-hydroxyproline: increased proline hydroxylation in patients with metformin-associated lactic acidosis and metformin-treated patients with Becker muscular dystrophy, Austria, Amino Acids, 2024; 56(1):21- Original publication Dimina,Laurianne Jolata ; Leray,Vincent ; Voute,Marion ; David,Jérémie ; Blavignac,Christelle ; Farges,Marie-Chantal ; Rossary,Adrien ; Tsikas,Dimitrios ; Rémond,Didier ; Pickering,Gisèle ; Mariotti,François ; Dietary Protein in a Challenge Meal Does Not Alleviate Postprandial Impairments in Vascular Endothelial Function in Healthy Older Adults with Cardiometabolic Risk: A Randomized Crossover-Controlled Trial J.Nutr, 2024, 154(12), 3664- 3680, Original publication Hedlund,Petter ; Rahardjo,Harrina E. ; Tsikas,Dimitrios ; Kuczyk,Markus A. ; Ückert,Stefan ; Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion therapy (MET) World J.Urol., 2024, 42(1), 654- , Original publication Hirsch,Merle S. ; Hildebrand, Christina B. ; Geltinger,Florian ; Pich,Andreas ; Mühlfeld,Christian ; Wedekind, Dirk ; Brandenberger, Christina ; Senescence in alveolar epithelial type II cells promotes acute lung injury and impairs regeneration,United States,Am.J.Respir.Cell Mol.Biol.,2024; ():- Original publication Hose, Leonie; Langenhagen, Alina Katharina; Kefalakes, Ekaterini; Schweitzer, Theresa ; Kubinski, Sabrina; Barak, Segev; Pich, Andreas ; Grothe, Claudia A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice. PMID: 38185886 Original publication Khan,Bushra ; Lanzuolo,Chiara ; Rosti,Valentina ; Santarelli,Philina ; Pich,Andreas ; Kraft,Theresia ; Amrute-Nayak,Mamta ; Nayak,Arnab ; Sorafenib induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes, United States,,2024;27(10):110913 Original publication Klawitter,Jost ; Weissenborn,Wiebke ; Gvon,Iuliia ; Walz,Mackenzie ; Klawitter,Jelena ; Jackson,Matthew ; Sempio,Cristina ; Joksimovic,Sonja L. ; Shokati,Touraj ; Just,Ingo ; Christians,Uwe ; Todorovic,Slobodan M. ; β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia? Mol. Pharmacol., 2024, 105(2), 75- 83, Original publication Krueger,Jonas ; Preusse,Matthias ; Oswaldo Gomez,Nicolas ; Frommeyer,Yannick Noah ; Doberenz,Sebastian ; Lorenz,Anne ; Kordes,Adrian ; Grobe,Svenja ; Müsken,Mathias; Depledge,Daniel P. ; Svensson,Sarah L. ; Weiss,Siegfried ; Kaever,Volkhard ; Pich,Andreas ; Sharma,Cynthia M. ; Ignatova,Zoya ; Häussler,Susanne ; tRNA epitranscriptome determines pathogenicity of the opportunistic pathogen Pseudomonas aeruginosa, United States,Proc.Natl.Acad.Sci.U.S.A.,2024;121(11):-e2312874121 Originalpublikation Kukoc-Modun, Lea; Kraljevic, Tomislav; Tsikas, Dimitrios ; Spassov, Tony G; Kolev, Spas D Determination of -Acetyl-L-cysteine Ethyl Ester (NACET) by Sequential Injection Analysis. PMID: 38257405 Original publication Neufeldt,Dimyana ; Schmidt,Arne ; Mohr,Elisa ; Lu,Dongchao; Chatterjee,Shambhabi ; Fuchs,Maximilian; Xiao,Ke ; Pan,Wen; Cushman,Sarah; Jahn,Christopher; Juchem,Malte; Hunkler,Hannah Jill ; Cipriano,Giuseppe ; Jürgens,Bjarne ; Schmidt,Kevin ; Groß,Sonja ; Jung,Mira ; Hoepfner,Jeannine ; Weber,Natalie ; Foo,Roger ; Pich,Andreas ; Zweigerdt,Robert ; Kraft,Theresia ; Thum,Thomas ; Bär,Christian ; Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival, Germany,Basic Res.Cardiol.,2024;119(4):613-632 Original publication Oms,Elisabeth ; Investigation of the RGD motif in the binding and uptake of C3bot in HT22 cells, Hannover,,2024;():-4 uncounted sheets, 98 sheets : Dissertation Posma,Rene A. ; Bakker,Stephan J. L. ; Nijsten,Maarten W. ; Touw,Daan J. ; Tsikas,Dimitrios ; Comprehensive GC-MS Measurement of Amino Acids, Metabolites, and Malondialdehyde in Metformin-Associated Lactic Acidosis at Admission and during Renal Replacement Treatment, Switzerland,J.Clin.Med.,2024;13(13):3692- Original publication Post,Adrian ; Groothof,Dion ; Kremer,Daan ; Knobbe,Tim J. ; Abma,Willem ; Koops,Christa A. ; Tsikas,Dimitrios ; Wallimann,Theo ; Dullaart,Robin P. F. ; Franssen,Casper F. M. ; Kema,Ido P. ; Heiner-Fokkema,M. Rebecca ; Bakker,Stephan J. L. ; Creatine homeostasis and the kidney: comparison between kidney transplant recipients and healthy controls, Austria,Amino Acids,2024;56(1):42- Original publication Przykopanski,Adina ; Investigation of the complex formation of the proteinogenic botulinum neurotoxin with its associated proteins and their influence on the transepithelial transport of the toxin 2023, Dissertation Sainz von Petzinger,Sylvana ; Protective effects of chitosan oligosaccharides against Clostridioides difficile toxin A and toxin B 2024, Master thesis Schmidt,Kevin ; Schmidt,Arne ; Groß,Sonja ; Just,Annette ; Pfanne,Angelika ; Fuchs,Maximilian ; Jordan,Maria ; Mohr,Elisa ; Pich,Andreas ; Fiedler,Jan ; Thum,Thomas ; SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation, England,Sci.Rep.,2024;14(1):16459- Original publication Scholz,Jonas ; Stephan,Till ; Pérez,Aina Gallemí ; Csiszár,Agnes ; Hersch,Nils ; Fischer,Lisa S. ; Brühmann,Stefan ; Körber,Sarah ; Litschko,Christof ; Mijanovic,Lucija ; Kaufmann,Thomas ; Lange,Felix ; Springer,Ronald ; Pich,Andreas ; Jakobs,Stefan ; Peckham,Michelle ; Tarantola,Marco ; Grashoff,Carsten ; Merkel,Rudolf ; Faix,Jan ; Decisive role of mDia-family formins in cell cortex function of highly adherent cells Sci.Adv., 2024, 10(44), - eadp5929, Original publication Tapken,Ines ; Schweitzer,Theresa ; Paganin,Martina ; Schüning,Tobias ; Detering,Nora T. ; Sharma,Gaurav ; Niesert,Moritz ; Saffari,Afshin ; Kuhn,Daniela ; Glynn,Amy ; Cieri,Federica ; Santonicola,Pamela ; Cannet,Claire ; Gerstner,Florian ; Faller,Kiterie M. E. ; Huang,Yu-Ting ; Kothary,Rashmi ; Gillingwater,Thomas H. ; Di Schiavi,Elia ; Simon,Christian M. ; Hensel,Niko ; Ziegler,Andreas ; Viero,Gabriella ; Pich,Andreas ; Claus,Peter ; The systemic complexity of a monogenic disease: the molecular network of spinal muscular atrophy Brain, 2024, (), - , Original publication Tsap,Mariana I. ; Yatsenko,Andriy S. ; Hegermann,Jan ; Beckmann,Bibiana ; Tsikas,Dimitros ; Shcherbata,Halyna R. ; Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier, England,Elife,2024;13():-e98020 Original publication Tsikas, Dimitrios Application of the Bland-Altman and Receiver Operating Characteristic (ROC) Approaches to Study Isotope Effects in Gas Chromatography-Mass Spectrometry Analysis of Human Plasma, Serum and Urine Samples Molecules, 29(2):365, 2024 ISSN:1420-3049 (electronic)PMID:38257277 "DOI:10.3390/molecules29020365 " Original publication Tsikas,Dimitrios ; Perspectives of quantitative GC-MS, LC-MS and ICP-MS in clinical medicine - The role of analytical chemistry, Switzerland, J.Clin.Med., 2024; 13(23):7276 Original publication Tsikas,Dimitrios ; Underlying mechanisms of chromatographic H/D, H/F, cis/trans and isomerization effects in GC-MS, Switzerland, 2025; 15(1):43 Original publication Waleczek,Florian J. G. ; Cipriano,Giuseppe ; Haas,Jonas A. ; Garg,Ankita ; Pfanne,Angelika ; Just,Annette ; Neumüller,Susanne ; Hegermann,Jan ; Pich,Andreas ; Radocaj,Ante ; Xiao,Ke ; Weber,Natalie ; Thum,Thomas ; Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure Int.J.Mol.Sci, 2024, 26(1), 218- , Original publication Wu,Xuekun ; Zheng,Linqun ; Reboll,Marc R. ; Hyde,Lillian F. ; Mass,Elvira ; Niessen,Hans W. ; Kosanke,Maike ; Pich,Andreas ; Giannitsis,Evangelos ; Tillmanns,Jochen ; Bauersachs,Johann ; Heineke,Joerg ; Wang,Yong ; Korf-Klingebiel,Mortimer ; Polten,Felix ; Wollert,Kai C. ; Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair, England,Nat.Cardiovasc.Res.,2024;3(2):186-202 Original publication Zobl,Walter ; Integration of in vitro methods into regulatory hazard assessment: two proof-of-concept case studies, Hannover,,2024;():IX, 20, 17 sheets, sheet 38, 14 sheets-77 : Illustrations, diagrams Dissertation 2023 Bousnaki,Maria; Bakopoulou,Athina; Grivas,Ioannis; Bekiari,Chrysa; Pich,Andreas ; Rizk,Marta; Keklikoglou,Kleoniki; Papachristou,Eleni; Papadopoulos,Georgios C.; Kritis,Aristeidis; Mikos,Antonios G.; Koidis,Petros; Treatment of TMJ osteoarthritis by dental stem cell secretome, United States,StemCell.Rev.Rep.,2023; 19(8):2957-2979 Original publication Deppe,Julian ; Investigation of the function of the HCN domain of clostridial neurotoxins, Hannover,,2022; ():V, 15, 22 sheets, pages VI-XXII : illustrations, diagrams Dissertation Eggenkemper,Lisa; Schlegtendal,Anne; Maier,Christoph; Lücke,Thomas; Brinkmann,Folke; Beckmann,Bibiana ; Tsikas,Dimitrios ; Koerner-Rettberg,Cordula; Impaired nitric oxide synthetase activity in primary ciliary dyskinesia-data-driven hypothesis, Switzerland,J.Clin.Med.,2023; 12(18):6010 Original publication Emons,Barbara; Arning,Larissa; Makulla,Vera-Estelle; Suchy,Maria-Theresia; Tsikas,Dimitrios ; Lücke,Thomas; Epplen,Jörg T.; Juckel,Georg; Roser,Patrik; Endocannabinergic modulation of central serotonergic activity in healthy human volunteers, England,Ann.Gen.Psychiatry.,2023; 22(1):11 Original publication Gao,Linfeng; Lam,Kwok-Ho; Liu,Shun; Przykopanski,Adina ; Lübke,Johanna; Qi,Ruifeng; Krüger,Maren; Nowakowska,Maria B.; Selby,Katja; Douillard,François P.; Dorner,Martin B.; Perry,Kay; Lindström,Miia; Dorner,Brigitte G.; Rummel,Andreas ; Jin,Rongsheng; Crystal structures of OrfX1, OrfX2 and the OrfX1-OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1, England, FEBS Lett.,2023597(4):524-537 10.1002/1873-3468.14576, Original publication Haukamp,Funmilola Josephine; Hartmann,Zoe Maria; Pich,Andreas ; Kuhn,Joachim; Blasczyk,Rainer; Stieglitz,Florian ; Bade-Döding,Christina; HLA-B*57:01/Carbamazepine-10,11-epoxide association triggers upregulation of NFkappaB and JAK/STAT signaling pathways, Switzerland,Cells,2023;12(5):676-10.3390 /cells12050676 Reporting year:2023 | ID: RefID:26161-haukamp2023hla-b*57:01/carbamazepine-1 Original publication Heils,Lucas; Schneemann,Martina; Gerhard,Ralf ; Schulzke,Jörg-Dieter; Bücker,Roland; CDT of Clostridioides difficile induces MLC-dependent intestinal barrier dysfunction in HT-29/B6 epithelial cell monolayers, Switzerland,Toxins (Basel),2023;15(1):54-10.3390 /toxins15010054, reporting year:2023 | ID: RefID:26111-heils2023cdt Original publication Hildebrand,Christina B.; Lichatz,Rita; Pich,Andreas ; Mühlfeld,Christian; Woltemate,Sabrina; Vital,Marius; Brandenberger,Christina; Short-chain fatty acids ameliorate aging and acute lung injury in old mice, United States,Am.J.Physiol.Lung Cell.Mol.Physiol.,2023;():- 10.1152/ajplung.00296.2022 Reporting year:2023 | ID: RefID:26113-hildebrand2023short Original publication Hollwedel, Femke D; Maus, Regina; Stolper, Jennifer; Iwai, Satoru; Kasai, Hayato; Holtfreter, Silva; Pich, Andreas ; Neubert, Lavinia; Welte, Tobias; Yamasaki, Sho; Maus, Ulrich A Ectopic expression of C-type lectin Mincle renders mice susceptible to staphylococcal pneumonia. PMID: 38159068 Original publication Joensuu,Merja; Syed,Parnayan; Saber,Saber H.; Lanoue,Vanessa; Wallis,Tristan P.; Rae,James; Blum,Ailisa; Gormal,Rachel S.; Small,Christopher; Sanders,Shanley; Jiang,Anmin; Mahrhold,Stefan ; Krez,Nadja; Cousin,Michael A.; Cooper-White,Ruby; Cooper-White,Justin J.; Collins,Brett M.; Parton,Robert G.; Balistreri,Giuseppe; Rummel,Andreas ; Meunier,Frederic A.; Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry, England,EMBO J.,2023;42(13):-e112095 10.15252/embj.2022112095 Reporting year:2023 | ID: RefID:39384-joensuu2023presynaptic Original publication Liu,Zheng; Lee,Pyung-Gang; Krez,Nadja; Lam,Kwok-Ho; Liu,Hao; Przykopanski,Adina ; Chen,Peng; Yao,Guorui; Zhang,Sicai; Tremblay,Jacqueline M.; Perry,Kay; Shoemaker,Charles B.; Rummel,Andreas ; Dong,Min; Jin,Rongsheng; Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, England,Nat.Commun.,2023;14(1):2338-10.1038/s41467-023-37860-8 Reporting year:2023 | ID: RefID:26323-liu2023structural Original publication Manion,John; Musser,Melissa A.; Kuziel,Gavin A.; Liu,Min; Schäfer,Amy; Wang,Siyu; Lee,Pyung-Gang; Zhao,Leo; Zhang,Jie; Marreddy,Ravi K. R.; Goldschmied,Jeffrey D.; Yuan,Ke; Hürde,Julian G. Gerhard,Ralf ; Jin,Rongsheng; Rakoff-Nahoum,Seth; Rao,Meenakshi; Dong,Min; C. difficile poisons neurons and pericytes to drive neurogenic inflammation, England,,2023; 622(7983):611-618 Original publication Baxolele Mhlekude, Dylan Postmus, Saskia Stenzel, January Weiner 3rd, Jenny Jansen, Francisco J Zapatero-Belinchón, Ruth Olmer, Anja Richter, Julian Heinze, Nicolas Heinemann, Barbara Mühlemann, Simon Schroeder, Terry C Jones, Marcel A Müller, Christian Drosten, Andreas Pich , Volker Thiel, Ulrich Martin, Daniela Niemeyer, Gisa Gerold, Dieter Beule, Christine Goffinet Pharmacologic inhibition of bromodomains and extraterminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection, United States, PLoS Pathog., 2023; ():- Original publication Mikuteit,Marie; Baskal,Svetlana ; Klawitter,Sandra; Dopfer-Jablonka,Alexandra; Behrens,Georg M. N.; Müller,Frank; Schröder,Dominik; Klawonn,Frank; Steffens,Sandra; Tsikas,Dimitrios ; Amino acids, posttranslational modifications, nitric oxide and oxidative stress in serum and urine of Long-COVID and Ex-COVID subjects, Austria,Amino Acids,2023; 55(9):1173-1188 Original publication Pankoke,Sophia; Schweitzer,Theresa ; Biker,Rolf; Pich,Andreas ; Pfarrer,Christiane; Mühlfeld,Christian; Schipke,Julia; Obesity affects lung hypoxia adaptation, United States,Am.J.Physiol.Lung Cell.Mol.Physiol.,2023; 325(3):L352-L359 Original publication Pokrant,Thomas; Hein,Jens Ingo; Körber,Sarah; Disanza,Andrea; Pich,Andreas ; Scita,Giorgio; Rottner,Klemens; Faix,Jan; Ena/VASP clustering at microspike tips involves lamellipodin but not I-BAR proteins and absolutely requires unconventional myosin-X, United States,Proc.Natl.Acad.Sci.U.S.A.,2023;120(2):-e2217437120 10.1073/pnas.2217437120 Reporting year:2023 | ID: RefID:26134-pokrant2023ena/vasp Original publication Rahardjo,Harrina E.; Märker,Viktoria; Tsikas,Dimitrios ; Kuczyk,Markus A.; Ückert,Stefan; Bannowsky,Andreas; Fibrotic diseases of the human urinary and genital tract: current understanding and potential treatment strategies, Switzerland,J.Clin.Med.,2023; 12(14):4770 Original publication Rahardjo,Harrina E. ; Ückert,Stefan ; Tsikas,Dimitrios ; Bannowsky,Andreas ; Kuczyk,Markus A. ; Becker,Armin J. ; Courses of Arginine-Vasopressin in the Systemic and Cavernous Blood through Different Stages of Sexual Arousal in Healthy Males and Patients with Erectile Dysfunction,,,2023;2023():7978734- Original publication Rohrbeck,Astrid ; Bruhn,Vanessa Anna ; Hussein,Nali ; Hagemann,Sandra ; Just,Ingo ; Clostridium botulinum C3bot-mediated effects on cytokine-induced psoriasis-like phenotype in full-thickness skin model, Germany,Naunyn Schmiedebergs Arch.Pharmacol.,2023; ():- Original publication Rosenstein,Christopher ; Identification of a second receptor binding pocket in botulinum neurotoxin F, Hannover,,2022;():-2 uncounted sheets, 77 sheets : 10.26068/mhhrpm/20230601-002 Reporting year:2023 | ID: RefID:26365-rosenstein2022identification Dissertation Schneemann,Martina; Heils,Lucas; Moos,Verena; Weiß,Franziska; Krug,Susanne M.; Weiner,January; Beule,Dieter; Gerhard,Ralf ; Schulzke,Jörg-Dieter; Bücker,Roland; A colonic organoid model exposed to the major toxins of Clostridioides difficile TcdA and TcdB exhibits deregulated tight junction proteins, Switzerland,Toxins (Basel),2023; 15(11):643 Original publication Schweitzer,Theresa ; Investigations on the effects of clostridial glucosylating toxins,Hannover,,2023; ():-VIII, 115 pages : illustrations, diagrams Dissertation Sinningen,Kathrin; Emons,Barbara; Böhme,Pierre; Juckel,Georg; Hanusch,Beatrice; Beckmann,Bibiana ; Tsikas,Dimitrios ; Lücke,Thomas; L-arginine/nitric oxide signaling pathway and oxidative stress in adults with ADHD: effects of methylphenidate treatment, United States, Nitric Oxide, 2023; 138-139():64-69 Original publication Tsikas,Dimitrios ; Acetazolamide and human carbonic anhydrases: Review, review and discussion of an intimate relationship, England,J.Enzyme Inhib.Med.Chem.,2024; 39(1):2291336 other Tsikas,Dimitrios ; Beckmann,Bibiana ; Baskal,Svetlana ; Brunner,Görig ; Pentafluoropropionic acid anhydride derivatization and GC-MS analysis of histamine, agmatine, putrescine and spermidine: effects of solvents and starting column temperature, Switzerland,Molecules,2023; 28(3):939 Original publication Tsikas,Dimitrios ; Beckmann,Bibiana ; Quality control in targeted GC-MS for amino acid OMICS, Switzerland,,2023; 13(9):986 Original publication Tsikas,Dimitrios ; Büttner,Petra; Do circulating concentrations of L-arginine metabolites predict coronary artery disease status and the likelihood of cardiovascular events?, Poland,Pol.Arch.Intern.Med.,2023;133(2):16429-10.20452 /pamw.16429 reporting:2023 | ID: RefID:26154-tsikas2023circulating Editorial Tsikas,Dimitrios ; GC-MS and GC-MS/MS measurement of malondialdehyde (MDA) in clinical studies: preanalytical and clinical considerations, Netherlands,J.Mass.Spectrom.Adv.Clin.Lab.,2023; 30():10-24 Overview Tsikas,Dimitrios ; GC-MS studies on nitric oxide autoxidation and S-nitrosothiol hydrolysis to nitrite in pH-neutral aqueous buffers: Definitive results using (15)N and (18)O isotopes, Switzerland,Molecules,2023; 28(11):4281-http://doi.org/10.3390/molecules28114281 original-publication Tsikas,Dimitrios ; Malondialdehyde-induced posttranslational modification of human hemoglobin, United States,J.Proteome Res.,2023; 22(6):2141-2143 commentary Tsikas,Dimitrios ; Mass spectrometry-based evaluation of the Bland-Altman approach: Review, discussion and proposal, Switzerland,Molecules,2023; 28(13):4905 review Tsikas,Dimitrios ; Measurement of nitro-oleic acid and nitro-linoleic acid in plasma by GC-MS/MS and LC-MS/MS in health and disease: The significance of the internal standard, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2023;1221():123684-10.1016/j.jchromb.2023.123684 Reporting year:2023 | ID: RefID:26250-tsikas2023measurement Letter Tsikas,Dimitrios ; Tsikas,Stefanos A.; Mikuteit,Marie; Ückert,Stefan; Circulating and urinary concentrations of malondialdehyde in aging people in health and disease: review and discussion, Switzerland,,2023; 11(10):2744 Overview Weißenborn,Wiebke ; Pharmacological investigations of the sesquiterpene BCP as a potential postoperative opioid alternative, Hannover,,2022; ():-4 uncounted sheets, 78 sheets Dissertation 2022 Baskal,S. ; Beckmann,B. ; Stahmer,L.; Peter,C.; Bohnhorst,B.; Das,A. M.; Tsikas,D. ; Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period, Austria,Amino Acids,2022;():- 10.1007/s00726-022-03197-7 Reporting year:2022 | ID: RefID:25095-baskal2022role Original publication Baskal,S. ; Bollenbach,A. ; Henzi,B.; Hafner,P.; Fischer,D.; Tsikas,D. ; Stable-Isotope Dilution GC-MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in Becker Muscular Dystrophy Patients Administered with Metformin, l-Citrulline, or Their Combination, Switzerland,Molecules,2022;27(12):3850-10.3390/molecules27123850 Reporting year:2022 | ID: RefID:25096-baskal2022stable-isotope Original publication Baskal,S. ; Dimina,L.; Tsikas,S. A.; Mosoni,L.; Remond,D.; Mariotti,F. ; Tsikas,D. ; Lysine and homoarginine are closely interrelated metabolites in the rat, Austria,Amino Acids,2022;54(6):967-976, 10.1007/s00726-022-03158-0 Reporting year:2022 | ID: RefID:25097-baskal2022lysine Original publication Baskal,S. ; Kaiser,A.; Mels,C.; Kruger,R.; Tsikas,D. ; Specific and sensitive GC-MS analysis of hypusine, N(epsilon)-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study Austria, Amino Acids, 2022, (), - , Reporting year: 2022| ID: 11345 (35243537) Original publication Baskal,S. ; Tsikas,S. A.; Begou,O.; Bollenbach,A. ; Lenzen,S.; Jörns,A.; Tsikas,D. ; Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-alpha Antibody-Based Therapy in the LEW.1AR1-iddm Rat, an Animal Model of Human Type 1 Diabetes Switzerland, Int.J.Mol.Sci., 2022, 23(3), 1541- , Reporting year: 2022| ID: 11166 (35163462) Original publication Baskal,Svetlana ; Tsikas,Dimitrios ; Free L-Lysine and Its Methyl Ester React with Glyoxal and Methylglyoxal in Phosphate Buffer (100 mM, pH 7.4) to Form Nepsilon-Carboxymethyl-Lysine, Nepsilon-Carboxyethyl-Lysine and Nepsilon-Hydroxymethyl-Lysine. Int J Mol Sci,2022;23(7):3446-10.3390/ijms23073446 Reporting year:2022 | ID: RefID:25100-baskal2022free Original publication Becker,E. ; Francino,A. ; Pich,A. ; Perrot,A. ; Kraft,T. ; Radocaj,A. ; , AQUA Mutant Protein Quantification of Endomyocardial Biopsy-Sized Samples From a Patient With Hypertrophic Cardiomyopathy Switzerland, Front.Cardiovasc.Med., 2022, 9(), 816330- ,Reporting year: 2022| ID: 11362 (35265683) Original publication Bense,S. ; Witte,J. ; Preuße,M. ; Koska,M. ; Pezoldt,L. ; Dröge,A. ; Hartmann,O. ; Müsken,M. ; Schulze,J. ; Fiebig,T. ; Bähre,H. ; Felgner,S. ; Pich,A. ; Häussler,S. ; Pseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels, England,Mol.Microbiol.,2022;117(5):1213-1226, 10.1111/mmi.14902 Reporting year:2022 | ID: RefID:25178-bense2022pseudomonas Original publication Bollenbach,A. ; Baskal,S. ; Mels,C. ; Kruger,R. ; Tsikas,D. ; Unusual Derivatization of Methylmalonic Acid with Pentafluorobenzyl Bromide to a Tripentafluorobenzyl Derivative and Its Stable-Isotope Dilution GC-MS Measurement in Human Urine, Switzerland,Molecules,2022;27(16):5202-10.3390/molecules27165202 Reporting year:2022 | ID: RefID:25229-bollenbach2022unusual Original publication Borgert,Sebastian Roman ; Henke,Steffi ; Witzgall,Florian ; Schmelz,Stefan ; Zur Lage,Susanne ; Hotop,Sven-Kevin ; Stephen,Steffi ; Lübken,Dennis ; Krüger,Jonas ; Gomez,Nicolas Oswaldo ; van Ham,Marco ; Jänsch,Lothar ; Kalesse,Markus ; Pich,Andreas ; Brönstrup,Mark ; Häussler,Susanne ; Blankenfeldt,Wulf ; Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa, England,Nat.Commun.,2022;13(1):7402-10.1038/s41467-022-35030-w, reporting year:2022 | ID: RefID:25237-borgert2022moonlighting Original publication Durisin,M. ; Krüger,C. ; Pich,A. ; Warnecke,A. ; Steffens,M. ; Zeilinger,C. ; Lenarz,T. ; Prenzler,N. ; Schmitt,H. ; Proteomic profile of patients with excellent and poor speech intelligibility after cochlear implantation: Can perilymph proteins predict performance? United States,PLoS One,2022;17(3):-e0263765, 10.1371/journal.pone.0263765 Reporting year:2022 | ID: RefID:25549-durisin2022proteome Original publication Fan,C. ; Wu,Z. ; Cooper,D. M. L. ; Magnus,A. ; Harrison,K. ; Eames, B. F. ; Chibbar,R. ; Groot,G. ; Huang,J. ; Genth,H. ; Zhang,J. ; Tan,X. ; Deng,Y. ; Xiang,J. ; Activation of focal adhesion kinase restores simulated microgravity-induced inhibition of osteoblast differentiation via the Wnt/beta-catenin signaling pathway, Switzerland,Int.J.Mol.Sci.,2022;23(10):5593-10.3390, /ijms23105593 reporting year:2022 | ID: RefID:25625-fan2022activation Original publication Gall,E. ; Stieglitz,F. ; Pich,A. ; Behrens,G. M. N. ; Kuhn,J. ; Blasczyk,R. ; Haukamp,F. J. ; Bade-Döding,C. ; Proteomic Profiling and T Cell Receptor Usage of Abacavir Susceptible Subjects, Switzerland,,2022;10(3):693-10.3390, /biomedicines10030693 reporting year:2022 | ID: RefID:25735-gall2022proteomic Original publication Hanusch,B. ; Sinningen,K. ; Brinkmann,F. ; Dillenhöfer,S. ; Frank,M. ; Jöckel,K. H. ; Koerner-Rettberg,C. ; Holtmann,M. ; Legenbauer,T. ; Langrock,C. ; Reinehr,T. ; Maasjosthusmann,P. ; Beckmann,B. ; Hamelmann,E. ; Tsikas,D. ; Lücke,T. ; Characterization of the L-arginine/nitric oxide pathway and oxidative stress in pediatric patients with atopic diseases, Switzerland,Int.J.Mol.Sci.,2022;23(4):2136-10.3390, /ijms23042136 Reporting year:2022 | ID: RefID:25936-hanusch2022Characterization Original publication Harre,Jennifer ; Heinkele,Laura ; Steffens,Melanie ; Warnecke,Athanasia ; Lenarz,Thomas ; Just, Ingo ; Rohrbeck,Astrid ; Corrigendum: Potentiation of brain-derived neurotrophic factor-induced protection of spiral ganglion neurons by C3 exoenzyme/Rho inhibitor, Switzerland,Front.Cell.Neurosci.,2022;16():1078962-10.3389 /fncel.2022.1078962 Reporting year:2022 | ID: RefID:25948-harre2022 Corrigendum: Corrigendum Haukamp,F. J. ; Gall,E. ; Hò,G. T. ; Hiemisch,W. ; Stieglitz,F. ; Kuhn,J. ; Blasczyk,R. ; Pich,A. ; Bade-Döding,C. ; Deciphering the proteomics of HLA-B*57:01(+) antigen-presenting cells during abacavir medication, Switzerland,J.Pers.Med.,2022;12(1):40-10.3390, /jpm12010040 Reporting year:2022 | ID: RefID:25968-haukamp2022unravelling Original publication Henkel,Daniel ; The receptor interaction of the Clostridioides difficile toxins TcdA and TcdB, Hannover,,2021;():-VII, 99 pages : illustrations, diagrams, reporting year:2022 | ID: RefID:26012-henkel2021die Dissertation Maassen,H. ; Said,M. Y. ; Frenay,A. S. ; Koning,A. ; Post,A. ; Riphagen,I. J. ; Heiner-Fokkema,M. R. ; Drabert,K. ; Fernandez,B. O. ; Gans,R. O. B. ; van den Berg,E. ; Navis,G. ; Tsikas,D. ; Feelisch,M. ; Bakker,S. J. L. ; van Goor,H. ; Nitric oxide and long-term outcomes after kidney transplantation: Results of the TransplantLines cohort study, United States,Nitric Oxide,2022;125-126():1-11 10.1016/j.niox.2022.05.005 Reporting year:2022 | ID: 11666 Original publication Malfeld,Kathrin ; Armbrecht,Nina ; Pich,Andreas ; Volk,Holger A. ; Lenarz,Thomas ; Scheper,Verena ; Prevention of noise-induced hearing loss in vivo: Continuous application of insulin-like growth factor 1 and its effect on inner ear synapses, auditory function and perilymph proteins, Switzerland,Int.J.Mol.Sci.,2022;24(1):291-10.3390 /ijms24010291 Reporting year:2022 | ID: RefID:23508-malfeld2022prevention Original publication Mangan,Matthew S. J. ; Gorki,Friederike ; Krause,Karoline ; Heinz,Alexander ; Pankow,Anne ; Ebert,Thomas ; Jahn,Dieter ; Hiller,Karsten ; Hornung,Veit ; Maurer,Marcus ; Schmidt,Florian I. ; Gerhard,Ralf ; Latz,Eicke ; Transcriptional licensing is required for pyrin inflammasome activation in human macrophages that is bypassed by mutations causing familial Mediterranean fever, United States,PLoS Biol.,2022;20(11):-e3001351 10.1371/journal.pbio.3001351 Reporting year:2022 | ID: RefID:23516-mangan2022transcriptional Original publication Neumann-Schaal,M; Groß,U; Just,I ; Jahn,D The Deadly Secrets of C. difficile-Insights Into Host-Pathogen Interaction. Front. Microbiol. 13:897612. doi: 10.3389/fmicb.2022.897612 (2022) Editorial Neumann-Schaal,Meina ; Groß,Uwe ; Just, Ingo ; Jahn,Dieter ; The Deadly Secrets of C. difficile-Insights into Host-Pathogen Interaction, Volume II, Switzerland,Front.Microbiol.,2022;13():896979-10.3389 /fmicb.2022.896979 Reporting year:2022 | ID: RefID:23740-neumann-schaal2022editorial: Editorial Nowakowska,M. B. ; Selby,K. ; Przykopanski,A. ; Krüger,M. ; Krez,N. ; Dorner,B. G. ; Dorner,M. B. ; Jin,R. ; Minton, N. P. ; Rummel,A. ; Lindström,M. ; Construction and validation of a safe Clostridium botulinum group II surrogate strain producing inactive botulinum neurotoxin type E, Toxoid, England, Sci.Rep.,2022;12(1):1790-10.1038/s41598-022-05008-1 Reporting year:2022 | ID: RefID:23775-nowakowska2022construction Original publication Petersen,Lara ; Stroh,Svenja ; Schöttelndreier,Dennis ; Grassl,Guntram A. ; Rottner,Klemens ; Brakebusch,Cord ; Fahrer,Jörg ; Genth,Harald ; The essential role of Rac1 glucosylation in B-induced arrest of the G1-S transition by Clostridioides difficile toxin,, Front Microbiol,2022;13():846215-10.3389 /fmicb.2022.846215 reporting year:2022 | ID: RefID:23897-petersen2022essential Original publication Piepgras,J. ; Rohrbeck,A. ; Just, Ingo ; Bittner,S. ; Ahnert-Hilger,G. ; Höltje,M. ; Enhancement of phosphorylation and transport activity of the neuronal glutamate transporter excitatory amino acid transporter 3 by C3bot and a 26mer C3bot peptide, Switzerland,Front.Cell.Neurosci.,2022;16():860823-10.3389 /fncel.2022.860823 Reporting year:2022 | ID: RefID:23925-piepgras2022enhancement Original publication Reboll,M. R. ; Klede,S. ; Taft,M. H. ; Cai,C. L. ; Feld,L. J. ; Lavine,K. J. ; Koenig,A. L. ; Fleischauer,J. ; Meyer,J. ; Schambach,A. ; Niessen,H. W. ; Kosanke,M. ; van den Heuvel,J. ; Pich,A. ; Bauersachs,J. ; Wu,X. ; Zheng,L. ; Wang,Y. ; Korf-Klingebiel,M. ; Pölten,F. ; Wollert,K. C. ; Meteorin-like promotes cardiac repair through endothelial KIT receptor tyrosine kinase, United States,Science,2022;376(6599):1343-1347 10.1126/science.abn3027 Reporting year:2022 | ID: RefID:24037-reboll2022meteorin-like Original publication Schweitzer,T. ; Genth,H. ; Pich,A. ; The alpha-toxin of Clostridium novyi alters the proteome and phosphoproteome of HEp-2 cells, Switzerland,Int.J.Mol.Sci.,2022;23(17):9939-10.3390 /ijms23179939 Reporting year:2022 | ID: RefID:24343-schweitzer2022clostridium Original publication Stieglitz,F. ; Gerhard,R. ; Hönig,R. ; Giehl,K. ; Pich,A. ; TcdB of Clostridioides difficile mediates RAS-dependent necrosis in epithelial cells, Switzerland,Int.J.Mol.Sci.,2022;23(8):4258-10.3390 /ijms23084258 Reporting year:2022 | ID: RefID:24479-stieglitz2022tcdb Original publication Stieglitz,Florian ; LC-MS-based characterization of effects on signaling molecules induced by Clostridioides difficile toxins, Hannover,,2022;():iv, 90 sheets, sheet v-viii : illustrations, diagrams, reporting year:2022 | ID: RefID:24480-stieglitz2022lc-ms-based Dissertation Tian,Songhai ; Xiong,Xiaozhe ; Zeng,Ji ; Wang,Siyu ; Tremblay,Benjamin Jean-Marie ; Chen,Peng ; Chen,Baohua ; Liu,Min ; Chen,Pengsheng ; Sheng,Kuanwei ; Zeve,Daniel ; Qi,Wanshu ; Breault,David T. ; Rodríguez,César ; Gerhard,Ralf ; Jin,Rongsheng ; Doxey,Andrew C. ; Dong,Min ; Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants, England,Nat.Commun.,2022;13(1):6786-10.1038/s41467-022-33964-9 Reporting year:2022 | ID: RefID:24582-tian2022identification Original publication Tsikas,D. ; Redfors,B. ; Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy, Switzerland,Int.J.Mol.Sci.,2022;23(9):4734-10.3390/ijms23094734 Reporting year:2022 | ID: RefID:24608-tsikas2022pilot Original publication Tsikas,Dimitrios ; Determination of equilibria constants of arginine:glycine amidinotransferase (AGAT)-catalyzed reactions using concentrations of circulating amino acids, Austria,Amino Acids,2022;():- 10.1007/s00726-022-03218-5, reporting year:2022 | ID: RefID:24610-tsikas2022determination Original publication Tsikas,Dimitrios ; Homoarginine in health and disease, England,Curr.Opin.Clin.Nutr.Metab.Care,2023;26(1):42-49, 10.1097/MCO.0000000000000889 Reporting year:2022 | ID: RefID:24609-tsikas2023homoarginine Overview Tsikas,Dimitrios ; Editorial,, Amino Acids,2022;54():481-484 10.1007/s00726-022-03164-2 Reporting year:2022 | ID: 11513 Editorial Tsikas,Dimitrios ; Mikuteit,Marie ; N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations. Amino Acids,2022;54(9):1251-1260, 10.1007/s00726-022-03185-x Overview van Dieken,A. ; Staecker,H. ; Schmitt,H. ; Harre,J. ; Pich,A. ; Roßberg,W. ; Lenarz,T. ; Durisin,M. ; Warnecke,A. ; Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas, Switzerland,Front.Cell.Dev.Biol.,2022;10():847157-10.3389/fcell.2022.847157 Reporting year:2022 | ID: RefID:24649-van2022bioinformatic Original publication von Hanstein,Anna-Sophie ; Tsikas,Dimitrios ; Lenzen,Sigurd ; Jörns,Anne ; Plötz,Thomas ; Potentiation of Lipotoxicity in Human EndoC-betaH1 Beta-cells by Glucose is Dependent on the Structure of Free Fatty Acids, Germany,Mol.Nutr.Food Res.,2023;():-e2200582, 10.1002/mnfr.202200582 Reporting year:2022 | ID: RefID:24703-from2023potentiation Original publication Wessig,A. K. ; Hoffmeister,L. ; Klingberg,A. ; Alberts,A. ; Pich,A. ; Brand,K. ; Witte,T. ; Neumann,K. ; Natural antibodies and CRP drive anaphylatoxin production by urate crystals, England,Sci.Rep.,2022;12(1):4483-10.1038/s41598-022-08311-z Reporting year:2022 | ID: RefID:24815-wessig2022natural Original publication 2021 Baskal,S. ; Bollenbach,A. ; Mels,C. ; Kruger,R. ; Tsikas,D. Development, validation of a GC-MS method for the simultaneous measurement of amino acids, their PTM metabolites and AGEs in human urine, and application to the bi-ethnic ASOS study with special emphasis to lysine, Austria,Amino Acids,2021;():- Originalpublikation Baskal,S. ; Bollenbach,A. ; Tsikas,D. Two-Step Derivatization of Amino Acids for Stable-Isotope Dilution GC-MS Analysis: Long-Term Stability of Methyl Ester-Pentafluoropropionic Derivatives in Toluene Extracts Switzerland,Molecules,2021;26(6):1726- Original publication Baskal,S. ; Bollenbach,A. ; Tsikas,D. GC-MS Discrimination of Citrulline from Ornithine and Homocitrulline from Lysine by Chemical Derivatization: Evidence of Formation of N(5)-Carboxy-ornithine and N(6)-Carboxy-lysine Switzerland,Molecules,2021;26(8):2301- Original publication Baskal,S. ; Büttner,P. ; Werner,S. ; Besler,C. ; Lurz,P. ; Thiele,H. ; Tsikas,D. Profile of urinary amino acids and their post-translational modifications (PTM) including advanced glycation end-products (AGEs) of lysine, arginine and cysteine in lean and obese ZSF1 rats, Austria, Amino Acids,2021;():- Original publication Baskal,S. ; Post,A. ; Kremer,D. ; Bollenbach,A. ; Bakker,S. J. L. ; Tsikas,D. Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality, Austria,Amino Acids,2021;():- Original publication Begou,O. ; Pavlaki,A. ; Deda,O. ; Bollenbach,A. ; Drabert,K. ; Gika,H. ; Farmaki,E. ; Dotis,J. ; Printza,N. ; Theodoridis,G. ; Tsikas,D. Diminished Systemic Amino Acids Metabolome and Lipid Peroxidation in Ureteropelvic Junction Obstruction (UPJO) Infants Requiring Surgery, Switzerland, J.Clin.Med.,2021;10(7):1467- Original publication Begou,O. ; Weber,K. ; Beckmann,B. ; Tsikas,D. GC-MS Studies on Derivatization of Creatinine and Creatine by BSTFA and Their Measurement in Human Urine, Switzerland, Molecules,2021;26(11):3206 [pii]- Original publication Bousnaki,M. ; Bakopoulou,A. ; Pich,A. ; Papachristou,E. ; Kritis,A. ; Koidis,P. Mapping the Secretome of Dental Pulp Stem Cells Under Variable Microenvironmental Conditions United States,Stem Cell.Rev.Rep.,2021;():- Original publication Büttner,P. ; Werner,S. ; Baskal,S. ; Tsikas,D. ; Adams,V. ; Lurz,P. ; Besler,C. ; Knauth,S. ; Bahls,M. ; Schwedhelm,E. ; Thiele,H. Arginine metabolism and nitric oxide turnover in the ZSF1 animal model for heart failure with preserved ejection fraction, England,Sci.Rep.,2021;11(1):20684- Original publication Chen,P. ; Zeng,J. ; Liu,Z. ; Thaker,H. ; Wang,S. ; Tian,S. ; Zhang,J. ; Tao,L. ; Gutierrez,C. B. ; Xing,L. ; Gerhard,R. ; Huang,L. ; Dong,M. ; Jin,R. Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection, England,Nat.Commun.,2021;12(1):3748- Original publication Fischer, V., Just, I. (2021) An integrated formula for determining the admission capacity in medical studies in reference to patients. Contributions to higher education research, 43(4), 52-65. Original publication Harre,J. ; Heinkele,L. ; Steffens,M. ; Warnecke,A. ; Lenarz,T. ; Just,I. ; Rohrbeck,A. Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor Switzerland,Front.Cell.Neurosci.,2021;15():602897- Original publication Kendre,G. ; Marhenke,S. ; Lorz,G. ; Becker,D. ; Reineke-Plaass,T. ; Poth,T. ; Murugesan,K. ; Kühnel,F. ; Woller,N. ; Wirtz,R. M. ; Pich,A. ; Marquardt,J. U. ; Saborowski,M. ; Vogel,A. ; Saborowski,A. The Co-mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion-Driven Cholangiocarcinoma, United States,Hepatology,2021;74(3):1357-1370 Original publication Klepka,C. ; Sandmann,M. ; Tatge,H. ; Mangan,M. ; Arens,A. ; Henkel,D. ; Gerhard,R. Impairment of lysosomal function by Clostridioides difficile TcdB England,Mol.Microbiol.,2021;():- Original publication Korf-Klingebiel,M. ; Reboll,M. R. ; Polten,F. ; Weber,N. ; Jäckle,F. ; Wu,X. ; Kallikourdis,M. ; Kunderfranco,P. ; Condorelli,G. ; Giannitsis,E. ; Kustikova,O. S. ; Schambach,A. ; Pich,A. ; Widder,J. D. ; Bauersachs,J. ; van den Heuvel,J. ; Kraft,T. ; Wang,Y. ; Wollert,K. C. Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Expression in Cardiomyocytes, United States,Circulation,2021;144(15):1227-1240 Original publication Kukoc-Modun,L. ; Kraljević,T. ; Tsikas,D. ; Radić,N. ; Modun,D. Determination of N-Acetyl-l-cysteine Ethyl Ester (NACET) by Flow Injection Analysis and Spectrophotometric Detection Using Different Thiol-Sensitive Ligands Switzerland,Molecules,2021;26(22):6826- Original publication Marquardt,I. ; Jakob,J. ; Scheibel,J. ; Hofmann,J. D. ; Klawonn,F. ; Neumann-Schaal,M. ; Gerhard,R. ; Bruder,D. ; Jänsch,L. Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells, Switzerland,Front.Microbiol.,2021;12():752549- Original publication Mhlekude,B. ; Lenman,A. ; Sidoyi,P. ; Joseph,J. ; Kruppa,J. ; Businge,C. B. ; Mdaka,M. L. ; Konietschke,F. ; Pich,A. ; Gerold,G. ; Goffinet,C. ; Mall,A. S. The barrier functions of crude cervical mucus plugs against HIV-1 infection in the context of cell-free and cell-to-cell transmission, England,AIDS,2021;35(3):2105-2117 Original publication Neumann,T. ; Krüger,M. ; Weisemann,J. ; Mahrhold,S. ; Stern,D. ; Dorner,M. B. ; Feraudet-Tarisse,C. ; Pöhlmann,C. ; Schulz,K. ; Messelhäusser,U. ; Rimek,D. ; Gessler,F. ; Elßner,T. ; Simon,S. ; Rummel,A. ; Dorner,B. G. Innovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies, Switzerland,Toxins (Basel),2021;13(4):266- Original publication Nickel,K. ; Wensorra,U. ; Wenck,H. ; Peters,N. ; Genth,H. Evaluation of Immunomodulatory Responses and Changed Wound Healing in Type 2 Diabetes-A Study Exploiting Dermal Fibroblasts from Diabetic and Non-Diabetic Human Donors, Switzerland,Cells,2021;10(11):2931- Original publication Ostermann,L. ; Maus,R. ; Stolper,J. ; Schütte,L. ; Katsarou,K. ; Tumpara,S. ; Pich,A. ; Mueller,C. ; Janciauskiene,S. ; Welte,T. ; Maus,U. A. Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice, United States,JCI Insight,2021;6(3):- Original publication Post,A. ; Bollenbach,A. ; Bakker,S. J. L. ; Tsikas,D. ; Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients, Austria, Amino Acids,2021;53(4):541-554 Original publication Schenke,M. ; Prause,H. C. ; Bergforth,W. ; Przykopanski,A. ; Rummel,A. ; Klawonn,F. ; Seeger,B. Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1, Switzerland,Toxins (Basel),2021;13(8):585- Original publication Schmitt,H. A. ; Pich,A. ; Prenzler,N. K. ; Lenarz,T. ; Harre,J. ; Staecker,H. ; Durisin,M. ; Warnecke,A. Personalized Proteomics for Precision Diagnostics in Hearing Loss: Disease-Specific Analysis of Human Perilymph by Mass Spectrometry, United States,ACS Omega,2021;6(33):21241-21254 Original publication Stieglitz,F. ; Gerhard,R. ; Pich,A. ; The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells, Switzerland,Front.Microbiol.,2021;12():725612- Original publication Stojanovic,S. D. ; Fuchs,M. ; Liang,C. ; Schmidt,K. ; Xiao,K. ; Just,A. ; Pfanne,A. ; Pich,A. ; Warnecke,G. ; Braubach,P. ; Petzold,C. ; Jonigk,D. ; Distler,J. H. W. ; Fiedler,J. ; Thum,T. ; Kunz,M. Reconstruction of the miR-506-Quaking axis in Idiopathic Pulmonary Fibrosis using integrative multi-source bioinformatics, England,Sci.Rep.,2021;11(1):12456- Original publication Tsikas,D. Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology-part I Austria, Amino Acids,2021;53(4):485-487 Editorial Tsikas,D. ; Comment on the article Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase, England,IUCrJ,2021;8(Pt 2):327-328 Comment Tsikas,D. ; Extra-platelet low-molecular-mass thiols mediate the inhibitory action of S-nitrosoalbumin on human platelet aggregation via S-transnitrosylation of the platelet surface, Austria, Amino Acids,2021;53(4):563-573 Original publication Tsikas,D. ; GC-MS Analysis of Biological Nitrate and Nitrite Using Pentafluorobenzyl Bromide in Aqueous Acetone: A Dual Role of Carbonate/Bicarbonate as an Enhancer and Inhibitor of Derivatization, Switzerland,Molecules,2021;26(22):7003- Original publication Tsikas,D. ; Homocysteine and copper ions: is their interaction responsible for cardiovascular-related damage? Austria, Amino Acids,2021;53(8):1297-1298 Letter Tsikas,D. ; Gambaryan,S. ; Nitrous anhydrase activity of carbonic anhydrase II: cysteine is required for nitric oxide (NO) dependent phosphorylation of VASP in human platelets England,J.Enzyme Inhib.Med.Chem.,2021;36(1):525-534 Original publication Ückert,S. ; Richter,K. ; Fischer,K. D. ; Tsikas,D. ; Kuczyk,M. A. Re-evaluation of the immunohistochemical distribution of isoforms of nitric oxide synthase in the human prostate: A light and electron microscopical study Germany,Andrologia,2021;53(7):e14098- Original publication Walter,L. M. ; Rademacher,S. ; Pich,A. ; Claus,P. Profilin2 regulates actin rod assembly in neuronal cells, England,Sci.Rep.,2021;11(1):10287- Original publication Wang,Y. ; Polten,F. ; Jäckle,F. ; Korf-Klingebiel,M. ; Kempf,T. ; Bauersachs,J. ; Freitag-Wolf,S. ; Lichtinghagen,R. ; Pich,A. ; Wollert,K. C. A mouse model of cardiogenic shock, England,Cardiovasc.Res.,2021;117(12):2414-2415 Letter Ahmadpour,Jamshid Investigation of antibody formation against botulinum neurotoxin A in the therapy of movement disorders Hannover,,2018;():4 uncounted pages, 76 pages : illustrations, - Dissertation Schneider,Carmen Intracellular activity of the pathogenic domain of large clostridial glucosyltransferases Hannover,,2021;():VII, 135 pages : illustrations, diagrams- Dissertation Weber,Kathrin GC-MS-based studies on the importance of renal carbonic anhydrases for the reabsorption of nitrite and oxidative stress in humans Hannover,,2020;():5 uncounted sheets, VI sheets, 102 sheets - Dissertation Hussein,Nali C3-mediated effects in psoriasis on the Phenion 3D full-thickness skin model, Hannover,,;():78 pages- Master thesis Langejürgen,Anna The role of macropinocytosis in the cellular uptake of C. difficile toxin Hannover,,;():74 Seiten- Master thesis von der Kammer,Urs Presentation of the interaction of botulinum neurotoxins serotype A and E with their protein receptors synaptic vesicle glycoprotein C and A, Hannover,,;():106 Seiten- Master thesis 2020 Adolf,A. ; Turko,P. ; Rohrbeck,A. ; Just,I. ; Vida,I. ; Ahnert-Hilger,G. ; Höltje,M. The Higher Sensitivity of GABAergic Compared to Glutamatergic Neurons to Growth-Promoting C3bot Treatment Is Mediated by Vimentin Switzerland,Front.Cell.Neurosci.,2020;14():596072- Original publication Alberts,A. ; Klingberg,A. ; Hoffmeister,L. ; Wessig,A. K. ; Brand,K. ; Pich,A. ; Neumann,K. Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures Switzerland,Front.Immunol.,2020;11():596103- Original publication Alberts,A. ; Klingberg,A. ; Wessig,A. K. ; Combes,C. ; Witte,T. ; Brand,K. ; Pich,A. ; Neumann,K. C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1 England,Sci.Rep.,2020;10(1):6391- Original publication Becker,T. ; Pich,A. ; Tamm,S. ; Hedtfeld,S. ; Ibrahim,M. ; Altmüller,J. ; Dalibor,N. ; Toliat,M. R. ; Janciauskiene,S. ; Tümmler,B. ; Stanke,F. Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B England,Sci.Rep.,2020;10(1):22447- Original publication Begou,O. ; Drabert,K. ; Theodoridis,G. ; Tsikas,D. GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine China,J.Pharm.Anal.,2020;10(1):49-59 Original publication Bollenbach,A. ; Gambaryan,S. ; Mindukshev,I. ; Pich,A. ; Tsikas,D. GC-MS and LC-MS/MS pilot studies on the guanidine (N(G))-dimethylation in native, asymmetrically and symmetrically N(G)-dimethylated arginine-vasopressin peptides and proteins in human red blood cells Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2020;1141():122024- Original publication Bollenbach,A. ; Schutte,A. E. ; Kruger,R. ; Tsikas,D. An Ethnic Comparison of Arginine Dimethylation and Cardiometabolic Factors in Healthy Black and White Youth: The ASOS and African-PREDICT Studies Switzerland,J.Clin.Med.,2020;9(3):844.- Original publication Bollenbach,A. ; Tsikas,D. Measurement of the tripeptides glutathione and ophthalmic acid by gas chromatography-mass spectrometry United States,Anal.Biochem.,2020;():- Original publication Brinkmann,F. ; Hanusch,B. ; Ballmann,M. ; Mayorandan,S. ; Bollenbach,A. ; Chobanyan-Jürgens,K. ; Jansen,K. ; Schmidt-Choudhury,A. ; Derichs,N. ; Tsikas,D. ; Lücke,T. Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results Switzerland,J.Clin.Med.,2020;9(6):E2012 [pii]- Original publication Craig,A. ; M C Mels,C. ; Tsikas,D. ; Boeger,R. H. ; Schwedhelm,E. ; Schutte,A. E. ; Kruger,R. Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study England,J.Hum.Hypertens.,2021;35(11):985-993 Original publication Craig,A. ; Mels,C. M. C. ; Schutte,A. E. ; Bollenbach,A. ; Tsikas,D. ; Schwedhelm,E. ; Kruger,R. ; Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study England,Hypertens.Res.,2021;44(1):71-79 Original publication Craig,A. ; Mels,C. M. C. ; Schutte,A. E. ; Tsikas,D. ; Kruger,R. ; Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies Austria,Amino Acids,2020;52(4):639-648 Original publication Cseko,K. ; Pecsi,D. ; Kajtar,B. ; Hegedus,I. ; Bollenbach,A. ; Tsikas,D. ; Szabo,I. L. ; Szabo,S. ; Helyes,Z. Upregulation of the TRPA1 Ion Channel in the Gastric Mucosa after Iodoacetamide-Induced Gastritis in Rats: A Potential New Therapeutic Target Switzerland,Int.J.Mol.Sci.,2020;21(16):E5591 [pii]- Original publication Deppe,J. ; Weisemann,J. ; Mahrhold,S. ; Rummel,A. The 25 kDa HCN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity Switzerland,Toxins (Basel),2020;12(12):- Original publication Hanusch,B. ; Brinkmann,F. ; Mayorandan,S. ; Chobanyan-Jürgens,K. ; Wiemers,A. ; Jansen,K. ; Ballmann,M. ; Schmidt-Choudhury,A. ; Bollenbach,A. ; Derichs,N. ; Tsikas,D. ; Lücke,T. Local and Systemic Alterations of the L-Arginine/Nitric Oxide Pathway in Sputum, Blood, and Urine of Pediatric Cystic Fibrosis Patients and Effects of Antibiotic Treatment Switzerland,J.Clin.Med.,2020;9(12)::E3802- Original publication Henkel,D. ; Tatge,H. ; Schöttelndreier,D. ; Tao,L. ; Dong,M. ; Gerhard,R. Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive Switzerland,Toxins (Basel),2020;12(12):- Original publication Hensel,N. ; Raker,V. ; Förthmann,B. ; Buch,A. ; Sodeik,B. ; Pich,A. ; Claus,P. The Proteome and Secretome of Cortical Brain Cells Infected With Herpes Simplex Virus Switzerland,Front.Neurol.,2020;11():844- Original publication Herkt,M. ; Foinquinos,A. ; Batkai,S. ; Thum,T. ; Pich,A. Pharmacokinetic Studies of Antisense Oligonucleotides Using MALDI-TOF Mass Spectrometry Switzerland,Front.Pharmacol.,2020;11():220- Original publication Ho,G. T. ; Hiemisch,W. ; Pich,A. ; Behrens,G. M. N. ; Blasczyk,R. ; Bade-Doeding,C. The Loss of HLA-F/KIR3DS1 Ligation Is Mediated by Hemoglobin Peptides Switzerland,Int.J.Mol.Sci.,2020;21(21):8012- Original publication Hobuss,L. ; Foinquinos,A. ; Jung,M. ; Kenneweg,F. ; Xiao,K. ; Wang,Y. ; Zimmer,K. ; Remke,J. ; Just,A. ; Nowak,J. ; Schmidt,A. ; Pich,A. ; Mazlan,S. ; Reamon-Buettner,S. M. ; Ramos,G. C. ; Frantz,S. ; Viereck,J. ; Loyer,X. ; Boulanger,C. ; Wollert,K. C. ; Fiedler,J. ; Thum,T. Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19 England,J.Mol.Cell.Cardiol.,2020;146():43-59 Originalpublication Hollwedel,F. D. ; Maus,R. ; Stolper,J. ; Khan,A. ; Stocker,B. L. ; Timmer,M. S. M. ; Lu,X. ; Pich,A. ; Welte,T. ; Yamasaki,S. ; Maus,U. A. Overexpression of Macrophage-Inducible C-Type Lectin Mincle Aggravates Proinflammatory Responses to Streptococcus pneumoniae with Fatal Outcome in Mice United States,J.Immunol.,2020;205(12):3390-3399 Original publication Jansen,K. ; Hanusch,B. ; Pross,S. ; Hanff,E. ; Drabert,K. ; Bollenbach,A. ; Dugave,I. ; Carmann,C. ; Siefen,R. G. ; Emons,B. ; Juckel,G. ; Legenbauer,T. ; Tsikas,D. ; Lücke,T. Enhanced Nitric Oxide (NO) and Decreased ADMA Synthesis in Pediatric ADHD and Selective Potentiation of NO Synthesis by Methylphenidate Switzerland,J.Clin.Med.,2020;9(1):pii: E175- Original publication Jansing,J. C. ; Fiedler,J. ; Pich,A. ; Viereck,J. ; Thum,T. ; Mühlfeld,C. ; Brandenberger,C. miR-21-KO Alleviates Alveolar Structural Remodeling and Inflammatory Signaling in Acute Lung Injury Switzerland,Int.J.Mol.Sci.,2020;21(3):E822- Original publication Kedia,G. T. ; Ückert,S. ; Tsikas,D. ; Becker,A. J. ; Kuczyk,M. A. ; Bannowsky,A. The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts Switzerland,J.Clin.Med.,2020;9(9):E2987- Overview Kropp,K. A. ; Srivaratharajan,S. ; Ritter,B. ; Yu,P. ; Krooss,S. ; Polten,F. ; Pich,A. ; Alcami,A. ; Viejo-Borbolla,A. Identification of the Cleavage Domain within Glycoprotein G of Herpes Simplex Virus Type 2 Switzerland,Viruses,2020;12(12):E1428 [pii]- Original publication Melzer,C. ; Jacobs,R. ; Dittmar,T. ; Pich,A. ; von der Ohe,J. ; Yang,Y. ; Hass,R. Reversible Growth-Arrest of a Spontaneously-Derived Human MSC-Like Cell Line Switzerland,Int.J.Mol.Sci.,2020;21(13):E4752.- Originalpublication Neu,A. ; Hornig,S. ; Sasani,A. ; Isbrandt,D. ; Gerloff,C. ; Tsikas,D. ; Schwedhelm,E. ; Choe,C. U. Creatine, guanidinoacetate and homoarginine in statin-induced myopathy Austria,Amino Acids,2020;52(6-7):1067-1069 Letter Schöttelndreier,D. ; Langejürgen,A. ; Lindner,R. ; Genth,H. Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor Switzerland,Front.Cell.Infect.Microbiol.,2020;10():565465- Originalpublication Stojanovic,S. D. ; Fuchs,M. ; Fiedler,J. ; Xiao,K. ; Meinecke,A. ; Just,A. ; Pich,A. ; Thum,T. ; Kunz,M. Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts Switzerland,Int.J.Mol.Sci.,2020;21(11):- Original publication Stojanovic,S. D. ; Fuchs,M. ; Kunz,M. ; Xiao,K. ; Just,A. ; Pich,A. ; Bauersachs,J. ; Fiedler,J. ; Sedding,D. ; Thum,T. Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells Switzerland,Front.Physiol.,2020;11():520- Original publication Tian,S. ; Liu,Y. ; Wu,H. ; Liu,H. ; Zeng,J. ; Choi,M. Y. ; Chen,H. ; Gerhard,R. ; Dong,M. Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL United States,Cell.Host Microbe,2020;27(5):782-792.e7 Original publication Tsikas,D. GC-MS approach revealing hidden nitrite reactions in hemolysate using (18)O-labeled nitrite and cysteine-based thiols United States,Anal.Biochem.,2020;():114025- Original publication Tsikas,D. Rat liver glutathione S-transferase-catalyzed conjugation of glutathione to the endogenous epoxides of oleic acid and cholesterol United States,Anal.Biochem.,2020;():113994- Original publication Tsikas,D. Urinary Dimethylamine (DMA) and Its Precursor Asymmetric Dimethylarginine (ADMA) in Clinical Medicine, in the Context of Nitric Oxide (NO) and Beyond Switzerland,J.Clin.Med.,2020;9(6):- Overview Tsikas,D. ; Surdacki,A. Biotransformation of organic nitrates by glutathione S-transferases and other enzymes: An appraisal of the pioneering work by William B. Jakoby United States,Anal.Biochem.,2020;():113993- Overview Yepes-Calderon,M. ; Sotomayor,C. G. ; Gans,R. O. B. ; Berger,S. P. ; Leuvenink,H. G. D. ; Tsikas,D. ; Rodrigo,R. ; Navis,G. J. ; Bakker,S. J. L. Post-transplant plasma malondialdehyde is associated with cardiovascular mortality in renal transplant recipients: a prospective cohort study England,Nephrol.Dial.Transplant,2020;35(3):512-519 Original publication Schöttelndreier,Dennis Expression and cellular internalization of Clostridium difficile Toxin A and Toxin B receptors Hannover,,2020;():VI, 75 sheets : illustrations, diagrams- Dissertation Kriedemann,Nils LC-MS based proteomic analysis of human endomyocardial heart biopsies of heart failure patients Hannover,,2020;():- Master thesis Scheele,Marven Integration of the SpyCatcher-SpyTag system in Clostridioides difficile Toxin B Hannover,,2020;():68 pages- Master thesis 2019 Bogutzki,A., Naue,N., Litz,L., Pich,A., Curth,U. E. coli primase and DNA polymerase III holoenzymes are able to bind concurrently to a primed template during DNA replication. Sci.Rep.2019;9(1):14460- http://dx.doi.org/10.1038/s41598-019-51031-0 Originalpublikation Bollenbach,A., Bakker,S. J. L., Tsikas,D. GC-MS measurement of biological N(G)-hydroxy-L-arginine, a stepmotherly investigated endogenous nitric oxide synthase substrate and arginase inhibitor Amino Acids,2019;51(4):627-64 http://dx.doi.org/10.1007/s00726-018-02695-x Original publication Bollenbach,A., Cordts,K., Hanff,E., Atzler,D., Choe,C. U., Schwedhelm,E., Tsikas,D. Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans Anal.Biochem.,2019;577():59-66 http://dx.doi.org/10.1016/j.ab.2019.04.019 Originalpublication Bollenbach,A., Hanff,E., Brunner,G., Tsikas,D. Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection Amino Acids,2019;51(6):961-971 http://dx.doi.org/10.1007/s00726-019-02737-y Original publication Bollenbach,A., Huneau,J. F., Mariotti,F., Tsikas,D. Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men Nutrients,2019;11(7):E1463- http://dx.doi.org/10.3390/nu11071463 Original publication Bollenbach,A., Tsikas,D., Lenzen,S., Jörns,A. Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-alpha antibody-based therapy Amino Acids,2020;52(1):103-110 http://dx.doi.org/10.1007/s00726-019-02811-5 Original publication Erdmann,J., Thöming,J. G., Pohl,S., Pich,A., Lenz,C., Häussler,S. The Core Proteome of Biofilm-Grown Clinical Pseudomonas aeruginosa Isolates Cells,2019;8(10):E1129 [pii]- http://dx.doi.org/10.3390/cells8101129 Original publication Grund,A., Szaroszyk,M., Korf-Klingebiel,M., Malek Mohammadi,M., Trogisch,F. A., Schrameck,U., Gigina,A., Tiedje,C., Gaestel,M., Kraft,T., Hegermann,J., Batkai,S., Thum,T., Perrot,A., Remedios,C. D., Riechert,E., Völkers,M., Doroudgar,S., Jungmann,A., Bauer,R., Yin,X., Mayr,M., Wollert,K. C., Pich,A., Xiao,H., Katus,H. A., Bauersachs,J., Müller,O. J., Heineke,J. TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation EMBO Mol.Med.,2019;11(10):e10018- http://dx.doi.org/10.15252/emmm.201810018 Original publication Hanff,E., Bollenbach,A., Beckmann,B., Brunner,G., Tsikas,D. GC-MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine Amino Acids,2020;52(2):225-234 http://dx.doi.org/10.1007/s00726-019-02786-3 Original publication Hanff,E., Ruben,S., Kreuzer,M., Bollenbach,A., Kayacelebi,A. A., Das,A. M., von Versen-Höynck,F., von Kaisenberg,C., Haffner,D., Ückert,S., Tsikas,D. Development and validation of GC-MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity Amino Acids,2019;51(3):529-547 http://dx.doi.org/10.1007/s00726-018-02688-w Original publication Hanff,E., Said,M. Y., Kayacelebi,A. A., Post,A., Minovic,I., van den Berg,E., de Borst,M. H., van Goor,H., Bakker,S. J. L., Tsikas,D. High plasma guanidinoacetate-to-homoarginine ratio is associated with high all-cause and cardiovascular mortality rate in adult renal transplant recipients Amino Acids,2019;51(10-12):1485-1499 http://dx.doi.org/10.1007/s00726-019-02783-6 Original publication Ho,G. T., Heinen,F. J., Blasczyk,R., Pich,A., Bade-Doeding,C. HLA-F Allele-Specific Peptide Restriction Represents an Exceptional Proteomic Footprint Int.J.Mol.Sci.,2019;20(22):E5572.- http://dx.doi.org/10.3390/ijms20225572 Original publication Kluge,A., Rangrez,A. Y., Kilian,L. S., Pott,J., Bernt,A., Frauen,R., Rohrbeck,A., Frey,N., Frank,D. Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy J.Mol.Cell.Cardiol.,2019;129():130-143 http://dx.doi.org/10.1016/j.yjmcc.2019.01.028 Original publication Kutschenko,A., Weisemann,J., Kollewe,K., Fiedler,T., Alvermann,S., Böselt,S., Escher,C., Garde,N., Gingele,S., Kaehler,S. B., Karachai,R., Krüger,T. H. C., Sikorra,S., Tacik,P., Wegner,F., Wollmann,J., Bigalke,H., Wohlfarth,K., Rummel,A. Botulinum neurotoxin serotype D - A potential treatment alternative for BoNT/A and B non-responding patients Clin.Neurophysiol.,2019;130(6):1066-1073 http://dx.doi.org/10.1016/j.clinph.2019.02.007 Original publication Nebl,J., Drabert,K., Haufe,S., Wasserfurth,P., Eigendorf,J., Tegtbur,U., Hahn,A., Tsikas,D. Exercise-Induced Oxidative Stress, Nitric Oxide and Plasma Amino Acid Profile in Recreational Runners with Vegetarian and Non-Vegetarian Dietary Patterns Nutrients,2019;11(8):E1875- http://dx.doi.org/10.3390/nu11081875 Original publication Pich,A., Junemann,J., Stieglitz,F., Schweitzer,T. Clostridioides difficile toxins alter the proteome of intestinal cells BIOspektrum,2019;25(6):633-636 http://dx.doi.org/10.1007/s12268-019-0213-0 Original publication Post,A., Said,M. Y., Gomes-Neto,A. W., van der Krogt,J., de Blaauw,P., Berger,S. P., Geleijnse,J. M., Borgonjen,K., van den Berg,E., van Goor,H., Rimbach,G., Kema,I. P., Tsikas,D., Heiner-Fokkema,M. R., Bakker,S. J. L. Urinary Taurine Excretion and Risk of Late Graft Failure in Renal Transplant Recipients Nutrients,2019;11(9):E2212- http://dx.doi.org/10.3390/nu11092212 Original publication Post,A., Tsikas,D., Bakker,S. J. L. Creatine is a Conditionally Essential Nutrient in Chronic Kidney Disease: A Hypothesis and Narrative Literature Review Nutrients,2019;11(5):E1044- http://dx.doi.org/10.3390/nu11051044 Overview Rahardjo,H. E., Ückert,S., Tsikas,D., Hedlund,P., Bannowsky,A., Kuczyk,M. A., Kedia,G. T. Arginase enzymes in the human prostate: A molecular biological and immunohistochemical approach Andrologia,2019;51(9):e13349- http://dx.doi.org/10.1111/and.13349 Original publication Said,M. Y., Bollenbach,A., Minovic,I., van Londen,M., Frenay,A. R., de Borst,M. H., van den Berg,E., Kayacelebi,A. A., Tsikas,D., van Goor,H., Navis,G., Bakker,S. J. L. Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients Amino Acids,2019;51(6):913-927 http://dx.doi.org/10.1007/s00726-019-02725-2 Original publication Said,M. Y., Douwes,R. M., van Londen,M., Minovic,I., Frenay,A. R., de Borst,M. H., van den Berg,E., Heiner-Fokkema,M. R., Kayacelebi,A. A., Bollenbach,A., van Goor,H., Navis,G., Tsikas,D., Bakker,S. J. L. Effect of renal function on homeostasis of asymmetric dimethylarginine (ADMA): studies in donors and recipients of renal transplants Amino Acids,2019;51(3):565-575 http://dx.doi.org/10.1007/s00726-018-02693-z Original publication Sasani,A., Hornig,S., Grzybowski,R., Cordts,K., Hanff,E., Tsikas,D., Böger,R., Gerloff,C., Isbrandt,D., Neu,A., Schwedhelm,E., Choe,C. U. Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure Amino Acids,2020;52(1):73-85 http://dx.doi.org/10.1007/s00726-019-02812-4 Original publication Schoenherr,C., Wohlan,K., Dallmann,I., Pich,A., Hegermann,J., Ganser,A., Hilfiker-Kleiner,D., Heidenreich,O., Scherr,M., Eder,M. Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase PLoS One,2019;14(12):e0225977- http://dx.doi.org/10.1371/journal.pone.0225977 Original publication Simper,G. S., Gräser,L. S., Celik,A. A., Kuhn,J., Kunze-Schumacher,H., Ho,G. T., Blasczyk,R., Pich,A., Bade-Doeding,C. The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity Pharmaceutics,2019;11(10):pii: E536- http://dx.doi.org/10.3390/pharmaceutics11100536 Original publication Sonnenschein,K., Fiedler,J., Pfanne,A., Just,A., Mitzka,S., Geffers,R., Pich,A., Bauersachs,J., Thum,T. Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury Cardiovasc.Res.,2019;115(12):1804-1810 http://dx.doi.org/10.1093/cvr/cvz063 Original publication Tao,L., Tian,S., Zhang,J., Liu,Z., Robinson-McCarthy,L., Miyashita,S. I., Breault,D. T., Gerhard,R., Oottamasathien,S., Whelan,S. P. J., Dong,M. Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells Nat.Microbiol.,2019;4(10):1760-1769 http://dx.doi.org/10.1038/s41564-019-0464-z Original publication Tsikas,D., Bollenbach,A., Hanff,E., Beckmann,B., Redfors,B. Synthesis of homoagmatine and GC-MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat Amino Acids,2020;52(2):235-245 http://dx.doi.org/10.1007/s00726-019-02808-0 Original publication Ückert,S., Kedia,G. T., Tsikas,D., Simon,A., Bannowsky,A., Kuczyk,M. A. Emerging drugs to target lower urinary tract symptomatology (LUTS)/benign prostatic hyperplasia (BPH): focus on the prostate,Germany,World J.Urol.,2020;38(6):1423-1435 http://dx.doi.org/10.1007/s00345-019-02933-1 Overview von Berg,L., Stern,D., Pauly,D., Mahrhold,S., Weisemann,J., Jentsch,L., Hansbauer,E. M., Müller,C., Avondet,M. A., Rummel,A., Dorner,M. B., Dorner,B. G. Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology Sci.Rep.,2019;9(1):5531- http://dx.doi.org/10.1038/s41598-019-41722-z Original publication von Berg,L., Stern,D., Weisemann,J., Rummel,A., Dorner,M. B., Dorner,B. G. Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments Toxins (Basel),2019;11(10):E588- http://dx.doi.org/10.3390/toxins11100588 Original publication Welz,B., Bikker,R., Junemann,J., Christmann,M., Neumann,K., Weber,M., Hoffmeister,L., Preuss,K., Pich,A., Huber,R., Brand,K. Proteome and Phosphoproteome Analysis in TNF Long Term-Exposed Primary Human Monocytes Int.J.Mol.Sci.,2019;20(5):E1241- http://dx.doi.org/10.3390/ijms20051241 Original publication Wieczorek-Surdacka,E., Hanff,E., Chyrchel,B., Kuzniewski,M., Surdacki,A., Tsikas,D. Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease Amino Acids,2019;51(6):977-982 http://dx.doi.org/10.1007/s00726-019-02738-x Original publication Zeleny,R., Rummel,A., Jansson,D., Dorner,B. G. Challenges in the Development of Reference Materials for Protein Toxins. In: Applications in Forensic Proteomics: Protein Identification and Profiling 2019; 1339: 185-202 http://dx.doi.org/doi:10.1021/bk-2019-1339.ch012 Book contribution, monograph 2018 Abere,B., Samarina,N., Gramolelli,S., Rückert,J., Gerold,G., Pich,A.,Schulz,T. F. Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-kinase PI3K-C2alpha To Activate Productive Viral Replication J.Virol. 2018; 92(17):e00544-18- Original publication http://dx.doi.org/10.1128/JVI.00544-18 Adolf,A., Rohrbeck,A., Münster-Wandowski,A., Johansson,M., Kuhn,H. G., Kopp,M. A., Brommer,B., Schwab,J. M., Just,I., Ahnert-Hilger,G., Höltje,M., Release of astroglial vimentin by extracellular vesicles: Modulation of binding and internalization of C3 transferase in astrocytes and neurons. Glia 2019; 67(4):703-717 Original publication http://dx.doi.org/10.1002/glia.23566 Aye,R., Weldearegay,Y. B., Lutta,H. O., Chuma,F., Pich,A., Jores,J., Meens,J., Naessens,J. Identification of targets of monoclonal antibodies that inhibit adhesion and growth in Mycoplasma mycoides subspecies mycoides. Vet.Immunol.Immunopathol. 2018; 204(11-18) Original publication http://dx.doi.org/10.1016/j.vetimm.2018.09.002 Beer,L. A., Tatge,H., Reich,N., Tenspolde,M., Olling,A., Goy,S., Rottner,K., Alekov,A. K., Gerhard,R. Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1-glucosylation kinetics are decisive for cell fate. Cell.Microbiol. 2018; 20(10):e12865- Original publication http://dx.doi.org/10.1111/cmi.12865 Beer,L. A., Tatge,H., Schneider,C., Ruschig,M., Hust,M., Barton,J., Thiemann,S., Fühner,V., Russo,G., Gerhard,R. The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains. Toxins (Basel) 2018; 10(6):E225- Original publication http://dx.doi.org/10.3390/toxins10060225 Bollenbach,A., Hanff,E., Beckmann,B., Kruger,R., Tsikas,D., GC-MS quantification of urinary symmetric dimethylarginine (SDMA), a whole-body symmetric l-arginine methylation index. Anal Biochem. 2018; 556(40-44) Original publication http://dx.doi.org/10.1016/j.ab.2018.06.021 Bollenbach,A., Hanff,E., Tsikas,D. Investigation of N(G)-hydroxy-l-arginine interference in the quantitative determination of nitrite and nitrate in human plasma and urine by GC-NICI-MS J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1100-1101(174-178) Original publication http://dx.doi.org/10.1016/j.jchromb.2018.10.007 Bollenbach,A., Hanff,E., Tsikas,D. Utility of homoarginine in the GC-MS quantification of asymmetric dimethylarginine (ADMA) in human serum proteins. Anal Biochem. 2018; 563(67-70) Original publication http://dx.doi.org/10.1016/j.ab.2018.10.012 Bollenbach,A., Tsikas,D. Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by N(G)-hydroxy-L-arginine, N(omega),N(omega)-dimethyl-L-citrulline and N(omega),N(omega)-dimethyl-N(delta)-hydroxy-L-citrulline: results and overview. Amino Acids 2019; 51(3):483-494 Original publication http://dx.doi.org/10.1007/s00726-018-2684-6 Chung,S. Y., Schöttelndreier,D., Tatge,H., Fühner,V., Hust,M., Beer,L. A., Gerhard,R. The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding Front.Microbiol. 2018; 9(2314- Originalpublication http://dx.doi.org/10.3389/fmicb.2018.02314 Erdmann,J., Preusse,M., Khaledi,A., Pich,A., Häussler,S. Environment-driven changes of mRNA and protein levels in Pseudomonas aeruginosa. Environ.Microbiol. 2018; 20(11):3952-3963 Original publication http://dx.doi.org/10.1111/1462-2920.14419 Finkel,A., Röhrich,M. A., Maassen,N., Lützow,M., Blau,L. S., Hanff,E., Tsikas,D., Maassen,M., Long-term effects of NO3(-) on the relationship between oxygen uptake and power after 3 weeks of supplemented HIHV training J.Appl.Physiol.(1985) 2018; 125(6):1997-2007 Original publication http://dx.doi.org/10.1152/japplphysiol.00176.2018 Fischer,V., Dudzinska,A., Just,I. The impact of the program structure at Hannover Medical School on academic success in medical studies GMS J.Med.Educ. 2018; 35(2):Doc22- Original publication http://dx.doi.org/10.3205/zma001169 Genth,H., Junemann,J., Lämmerhirt,C. M., Lücke,A. C., Schelle,I., Just,I., Gerhard,R., Pich,A. Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018 Front.Microbiol. 2018; 9(3078- Original publication http://dx.doi.org/10.3389/fmicb.2018.03078 Hanff,E., Hafner,P., Bollenbach,A., Bonati,U., Kayacelebi,A. A., Fischer,D., Tsikas,D. Effects of single and combined metformin and L-citrulline supplementation on L-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications Amino Acids 2018; 50(10):1391-1406 Original publication http://dx.doi.org/10.1007/s00726-018-2614-7 Hanff,E., Zinke,M., Böhmer,A., Niebuhr,J., Maassen,M., Endeward,V., Maassen,N., Tsikas,D. GC-MS determination of nitrous anhydrase activity of bovine and human carbonic anhydrase II and IV Anal.Biochem. 2018; 550(132-136) Original publication http://dx.doi.org/10.1016/j.ab.2018.05.001 Junemann,J., Just,I., Gerhard,R., Pich,A. Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells Front.Microbiol. 2018; 9(3083- Original publication http://dx.doi.org/10.3389/fmicb.2018.03083 Just,I., Fischer,V. Examinations at Hannover Medical School - How to get from actual to target? Wien.Med.Wochenschr. 2019; 169(5-6):119-125 Original publication http://dx.doi.org/10.1007/s10354-018-0663-x Lam,K. H., Sikorra,S., Weisemann,J., Maatsch,H., Perry,K., Rummel,A., Binz,T., Jin,R. Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA Pathog.Dis. 2018; 76(4):10.1093/femspd/fty044- Original publication http://dx.doi.org/10.1093/femspd/fty044 Mehner-Breitfeld,D., Rathmann,C., Riedel,T., Just,I., Gerhard,R., Overmann,J., Brüser,T. Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile Front.Microbiol. 2018; 9(2446- Originalpublication http://dx.doi.org/10.3389/fmicb.2018.02446 Montag,J., Kowalski,K., Makul,M., Ernstberger,P., Radocaj,A., Beck,J., Becker,E., Tripathi,S., Keyser,B., Mühlfeld,C., Wissel,K., Pich,A., van der Velden,J., Dos Remedios,C. G., Perrot,A., Francino,A., Navarro-Lopez,F., Brenner,B., Kraft,T. Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy Front.Physiol. 2018; 9(359- Original publication http://dx.doi.org/10.3389/fphys.2018.00359 Rahardjo,H. E., Ückert,S., Bannowsky,A., Tsikas,D., Becker,A. J., Kuczyk,M. A. Course of transforming growth factor ss1 in the systemic and cavernous blood of healthy males through different penile conditions Andrologia 2019; 51(1):e13150- Original publication http://dx.doi.org/10.1111/and.13150 Schöttelndreier,D., Seeger,K., Grassl,G. A., Winny,M. R., Lindner,R., Genth,H. Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B Front.Microbiol. 2018; 9(1483- Originalpublication http://dx.doi.org/10.3389/fmicb.2018.01483 Schröder,A., Benski,A., Oltmanns,A., Just,I., Rohrbeck,A., Pich,A. MS-based quantification of RhoA/B and RhoC ADP-ribosylation J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1092(268-271) Original publication http://dx.doi.org/S1570-0232(18)30604-4 Shahin,P., Rahardjo,H. E., Bannowsky,A., Tsikas,D., Sohn,M., Kuczyk,M. A., Ückert,S. Endopeptidase inhibition attenuates the contraction induced by big endothelin-1 of isolated human penile erectile tissue Andrologia 2018; 50(5):e13008- Original publication http://dx.doi.org/10.1111/and.13008 Sikorra,S., Skiba,M., Dorner,M. B., Weisemann,J., Weil,M., Valdezate,S., Davletov,B., Rummel,A., Dorner,B. G., Binz,T. Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q(58)(-)K(59) Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities Toxins (Basel) 2018; 10(8):E311- Original publication http://dx.doi.org/10.3390/toxins10080311 Stern,D., Weisemann,J., Le Blanc,A., von Berg,L., Mahrhold,S., Piesker,J., Laue,M., Luppa,P. B., Dorner,M. B., Dorner,B. G., Rummel,A. A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency PLoS Pathog. 2018; 14(5):e1007048- Original publication http://dx.doi.org/10.1371/journal.ppat.1007048 Tan,X., Xu,A., Zhao,T., Zhao,Q., Zhang,J., Fan,C., Deng,Y., Freywald,A., Genth,H., Xiang,J., Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways Sci.Rep. 2018; 8(1):3769- Original publication http://dx.doi.org/10.1038/s41598-018-20459-1 Tsikas,D., Bioanalytical method validation of endogenous substances according to guidelines by the FDA and other organizations: Basic need to specify concentration ranges J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1093-1094(80-81) Letter http://dx.doi.org/10.1016/j.jchromb.2018.07.005 Tsikas,D., Bollenbach,A., Hanff,E., Kayacelebi,A. A. Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes Cardiovasc.Diabetol. 2018; 17(1):1- Comment http://dx.doi.org/10.1186/s12933-017-0656-x Tsikas,D., Hanff,E. Measurement of S -Nitrosoglutathione in Plasma by Liquid Chromatography-Tandem Mass Spectrometry Methods Mol.Biol. 2018; 1747(113-129 Original publication http://dx.doi.org/10.1007/978-1-4939-7695-9_10 Tsikas,D., Hanff,E., Bollenbach,A., Kruger,R., Pham,V. V., Chobanyan-Jürgens,K., Wedekind,D., Arndt,T., Jörns,A., Berbee,J. F. P., Princen,H. M. G., Lücke,T., Mariotti,F., Huneau,J. F., Ückert,S., Frölich,J. C., Lenzen,S., Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings Amino Acids 2018; 50(7):799-821 Original publication http://dx.doi.org/10.1007/s00726-018-2573-z Wolling,H., Konze,S. A., Höfer,A., Erdmann,J., Pich,A., Zweigerdt,R., Buettner,F. F. R., Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis Proteomics 2018; 18(14):e1800102- Original publication http://dx.doi.org/10.1002/pmic.201800102 Zhao,T., Li,R., Tan,X., Zhang,J., Fan,C., Zhao,Q., Deng,Y., Xu,A., Lukong,K. E., Genth,H., Xiang,J., Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-kappaB and ERK1/2 Pathways Int.J.Mol.Sci. 2018; 19(7):E1994- Original publication http://dx.doi.org/10.3390/ijms19071994 2017 Buck A, Kayacelebi A A, Chobanyan-Jürgens K, Illsinger S, Bohnhorst B, Beckmann B, Hanff E, Das A M, Tsikas D, Lücke T Comprehensive analysis of the L-arginine/L-homoarginine/nitric oxide pathway in preterm neonates: potential roles for homoarginine and asymmetric dimethylarginine in fetal growth. Amino Acids 2017; 49(4):783-794 Original publication Full text Debez A, Belghith I, Pich A, Taamalli W, Abdelly C, Braun H P High salinity impacts germination of the halophyte Cakile maritima but primes seeds for rapid germination upon stress release. Physiol. Plant. 2017, ppl.12679- Original publication Full text Erdmann J, Junemann J, Schröder A, Just I, Gerhard R, Pich A Glucosyltransferase-dependent and -independent effects of TcdB on the proteome of HEp-2 cells. Proteomics 2017; 17(15-16):1600435- Original publication Full text Fischer V, Just I Quality assurance in examinations using the example of 10 years of e-examinations at the MHH. Quality in Science (QiW) 2017; 11(2):60-64 Original publication Full text Günes D N, Kayacelebi A A, Hanff E, Lundgren J, Redfors B, Tsikas D Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat. Amino Acids 2017; 49(12):2033-2044 Original publication Full text Haghikia A, Yanchev G R, Kayacelebi A A, Hanff E, Bledau N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Bauersachs J, Bavendiek U, Tsikas D The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients. Amino Acids 2017; 49(6):1111-1121 Original publication Full text Hoepfner J, Kleinsorge M, Papp O, Alfken S, Heiringhoff R, Pich A, Sauer V, Zibert A, Göhring G, Schmidt H, Sgodda M, Cantz T In vitro modeling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells. Biol.Chem. 2017; 398(8):939-954 Original publication Full text Junemann J, Lämmerhirt C M, Polten F, Just I, Gerhard R, Genth H, Pich A Quantification of small GTPase glucosylation by clostridial glucosylating toxins using multiplexed MRM analysis. Proteomics 2017; 17(9):1700016- Original publication Full text Kayacelebi A A, Minovic I, Hanff E, Frenay A S, de Borst M H, Feelisch M, van Goor H, Bakker S J L, Tsikas D Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients. Amino Acids 2017; 49(7):1193-1202 Original publication Full text Konze S A, Cajic S, Oberbeck A, Hennig R, Pich A, Rapp E, Buettner F F R Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells. Chembiochem 2017; 18(13):1317-1331 Original publication Full text Konze S A, Werneburg S, Oberbeck A, Olmer R, Kempf H, Jara-Avaca M, Pich A, Zweigerdt R, Buettner F F Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms. J. Proteome Res. 2017; 16(3):1133-1149 Original publication Full text Kukoc-Modun L, Tsikas D, Kraljevi T, Biocic M, Radi N Kinetic Spectrophotometric Determination of N-Acetyl-L-cysteine Ethyl Ester (NACET) Generating Chromogenic Copper(I)Ln Complexes with Different Ligands. Croat. Chem. Acta 2017; 90(2):263-271 Original publication Full text Lam K H, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein. Toxicon 2017; DOI: 10.1016/j.toxicon.2017.10.012- Original publication Full text Nkuipou-Kenfack E, Schanstra J P, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands J L, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber T B, Rudolph K L, Pich A, Mischak H, Zürbig P The use of urinary proteomics in the assessment of suitability of mouse models for ageing. PLoS One 2017; 12(2):e0166875- Original publication Full text Peck M W, Smith T J, Anniballi F, Austin J W, Bano L, Bradshaw M, Cuervo P, Cheng L W, Derman Y, Dorner B G, Fisher A, Hill K K, Kalb S R, Korkeala H, Lindström M, Lista F, Luquez C, Mazuet C, Pirazzini M, Popoff M R, Rossetto O, Rummel A, Sesardic D, Singh B R, Stringer S C Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature. Toxins (Basel) 2017; 9(1):DOI: 10.3390/toxins9010038- Overview Full text Reboll M R, Korf-Klingebiel M, Klede S, Polten F, Brinkmann E, Reimann I, Schonfeld H J, Bobadilla M, Faix J, Kensah G, Gruh I, Klintschar M, Gaestel M, Niessen H W, Pich A, Bauersachs J, Gogos J A, Wang Y, Wollert K C EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction. Circulation 2017; 136(19):1809-1823 Original publication Full text Rohrbeck A, Höltje M, Adolf A, Oms E, Hagemann S, Ahnert-Hilger G, Just I The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif. J. Biol. Chem. 2017; 292(43):17668-17680 Original publication Full text Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, Gerhard R, Alekov A Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB. Front. Cell. Infect. Microbiol. 2017; 7(67- Original publication Full text Rummel A Two Feet on the Membrane: Uptake of Clostridial Neurotoxins. Curr.Top.Microbiol.Immunol. 2016; DOI: 10.1007/82_2016_48- Overview Full text Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, Lenarz T, Warnecke A Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics. PLoS One 2017; 12(5):e0178182- Original publication Full text Tsikas D Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first. Atherosclerosis 2017; 264:79-82 Editorial Full text Tsikas D The dilemma of oxidative stress personified by the disprosopus 8-iso-prostaglandin F2a and prostaglandin F2a. J Controversies Biomed Res 2017; 3(1):11-15 Original publication Full text Tsikas D Does oxidative stress change during orthotopic liver transplantation? J Controversies Biomed Res 2017; 3(2):1-5 Original publication Full text Tsikas D Does the Inhibitory Action of Asymmetric Dimethylarginine (ADMA) on the Endothelial Nitric Oxide Synthase Activity Explain Its Importance in the Cardiovascular System? The ADMA Paradox. J Controversies Biomed Res 2017; 3(1):16-22 Original publication Full text Tsikas D Letter to the Editor regarding "Identification of the oleic acid ethanolamide (OEA) isomer cis-vaccenic acid ethanolamide (VEA) as a highly abundant 18:1 fatty acid ethanolamide in blood plasma from rats and humans&quot. Anal.Bioanal Chem. 2017; 409(9):2495- Letter Full text Tsikas D Measuring NO production rate from l-arginine in MELAS by mass spectrometry-based approaches: GC-MS or LC-MS/MS? Int.J.Cardiol. 2017; DOI: 10.1016/j.ijcard.2017.11.040- Letter Full text Tsikas D Peroxynitrite-mediated 9,10-dihydroxylation of deuterium-labeled oleic acid in human hemolysate to threo- and erythro-dihydroxy-[9,10-2H2]stearic acid. JSM Biochem Mol Biol 2017; 4(2):1027- Original publication Full text Tsikas D What we-authors, reviewers and editors of scientific work-can learn from the analytical history of biological 3-nitrotyrosine. J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1058:68-72 Overview Full text Tsikas D, Böhmer A S-Transnitrosation reactions of hydrogen sulfide (H2S/HS-/S2-) with S-nitrosated cysteinyl thiols in phosphate buffer of pH 7.4: Results and review of the literature. Nitric Oxide 2017; 65:22-36 Original publication Full text Tsikas D, Bollenbach A, Savvidou M D Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction? Amino Acids 2017; DOI: 10.1007/s00726-017-2522-2- Original publication Full text Tsikas D, Eigendorf J Diet and Exercise and Serum Markers of Oxidative Stress-Letter. Cancer.Prev.Res.(Phila) 2017; 10(8):485-486 Letter Full text Tsikas D, Hanff E Lacking linearity in quantitative stable-isotope LC-MS/MS measurement of F2-isoprostanes is an irrefutable indicator of analytical inadequacy. J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1064:139-142 Overview Full text Tsikas D, Hanff E, Becker T Drastic decrease of global l-arginine bioavailability during orthotopic liver transplantation: A matter of ATP deficiency of the graft? Nitric Oxide 2017;73: 96-97; DOI: 10.1016/j.niox.2017.02.009- Letter Full text Tsikas D, Hanff E, Bollenbach A S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-adenosyl-L-methionine's chemistry, physiology and pharmacokinetics. World J Gastroenterol. 2017; 23(40):7343-7346 Letter Full text Tsikas D, Hanff E, Brunner G Helicobacter pylori, Its Urease and Carbonic Anhydrases, and Macrophage Nitric Oxide Synthase. Trends Microbiol. 2017; 25(8):601-602 Letter Full text Tsikas D, Hanff E, Brunner G Spermidine for a long, dementia-free life? Glob J Pharmaceu Sci 2017; 2(1):GJPPS.MS.ID.555576- Overview Full text Tsikas D, Kinzel M Associations between asymmetric dimethylarginine (ADMA), nitrite-dependent renal carbonic anhydrase activity and plasma testosterone levels in hypogonadal men. Hellenic J.Cardiol. 2017; DOI: 10.1016/j.hjc.2017.10.004- Original publication Full text Tsikas D, Savvidou M Plasma Oleic Acid Oxide in Women at Risk of Preeclampsia Correlates Inversely with Birthweight Centile. JSM Biochem Mol Biol 2017; 4(2):1028- Original publication Full text Tsikas D, Schwedhelm K S, Surdacki A, Giustarini D, Rossi R, Kukoc-Modun L, Kedia G, Ückert S S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET) Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants:Results and overview. 2017; 8(1):1-9; DOI: 10.1016/j.jpha.2017.12.003- Original publication Full text by Elsner L, Hagemann S, Just I, Rohrbeck A Anti-proliferative Effect of C3 Exoenzyme in Fibroblasts is Mediated by c-Jun Phosphorylation. J Mol Signal 2017; 12(1- Original publication Full text Yao G, Lam K H, Perry K, Weisemann J, Rummel A, Jin R Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H. Toxins (Basel) 2017; 9(3):93; DOI:10.3390/toxins9030093- Original publication Full text Yao G, Lam K H, Weisemann J, Peng L, Krez N, Perry K, Shoemaker C B, Dong M, Rummel A, Jin R A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding. Sci. Rep. 2017; 7(1):7438- Original publication Full text Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission. PLoS Pathog. 2017; 13(8):DOI: 10.1371/journal.ppat.1006567- Original publication Full text 2016 Frädrich C, Beer LA, Gerhard R Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B Toxins (Basel) 2016; 8 (1), 25 Overview Abstract Böhmer A, Pich A, Schmidt M, Haghikia A, Tsikas D Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells Journal of Chromatography B. Analyt Technol.Biomed.Life.Sci. 2016; 1019 (72-82) Original publication Abstract Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme Journal of Neurochemistry 2016; 139 (2): 234-244 Original publication Full text Dong L, Helmke A, Waisman A, Haller H, Pich A, von Vietinghoff S Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization Scientific Reports 2016; 6 (36598-) Original publication Full text Dorner BG, Zeleny R, Harju K, Hennekinne JA, Vanninen P, Schimmel H, Rummel A Biological toxins of potential bioterrorism risk: Current status of detection and identification technology TrAC Trends in Analytical Chemistry 2016; 85 (Part B): 89-102 Overview Abstract Gerhard R Receptors and Binding Structures for Clostridium difficile Toxins A and B Current Topics in Microbiology and Immunology 2016: 1-18 Original publication Abstract Krueger J, Pohl S, Preusse M, Kordes A, Rugen N, Schniederjans M, Pich A, Häussler S Unraveling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa Environmental Microbiology 2016; 18 (10): 3583-3592 Original publication Full text Mahrhold S, Bergström T, Stern D, Dorner BG, Astot C, Rummel A Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1 Biochemical Journal 2016; 473 (17): 2645-2654 Original publication Full text Rohrbeck A, Fühner V, Schröder A, Hagemann S, Vu XK, Berndt S, Hust M, Pich A, Just I Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody Toxins (Basel) 2016; 8(4):100 Original publication Full text Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M Frizzled proteins are colonic epithelial receptors for C. difficile toxin B Nature 2016; 538(7625): 350-355 Original publication Full text von Elsner L, Hagemann S, Just I, Rohrbeck A C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors Naunyn Schmiedeberg's Archives of Pharmacology 2016; 389 (9): 1021-1031 Original publication Full text Weisemann J, Stern D, Mahrhold S, Dorner BG, Rummel A Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin Toxins (Basel) 2016; 8(5), 154 Original publication Full text Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A Nature Structural & Molecular Biology 2016; 23 (7): 656-662 Original publication Full text Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS Proc.Natl.Acad.Sci.U.S.A. 2016; 113 (8): E1034-E1043 Original publication Full text Junemann J, Birgin G, Erdmann J, Schröder A, Just I, Gerhard R, Pich A Toxin A of the nosocomial pathogen Clostridium difficile induces primary effects in the proteome of HEp-2 cells Germany : WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Proteomics Clinical Applications 2016; 11 (3-4) Original publication Full text Genth H, Schelle I, Just I Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B Toxins (Basel) 2016; 8 (4): 109 Original publication Full text Hansbauer EM, Skiba M, Endermann T, Weisemann J, Stern D, Dorner MB, Finkenwirth F, Wolf J, Luginbühl W, Messelhäußer U, Bellanger L, Woudstra C, Rummel A, Fach P, Dorner BG Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry Analyst 2016; 141 (18): 5281 -5297 Original publication Full text Kutschenko A, Reinert MC, Krez N, Liebetanz D, Rummel A BoNT/AB hybrid maintains similar duration of paresis as BoNT/A wild-type in murine running wheel assay Netherlands : Elsevier B.V, NeuroToxicology 2016; 59: 1-8 Original publication Abstract Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells Denmark : John Wiley & Sons A/S. Published by John Wiley & Sons Ltd, Experimental Dermatology 2017; 26 (1): 44-50 Original publication Full text Schelle I, Bruening J, Buetepage M, Genth H Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B Toxins (Basel) 2016; 9 (1), 2 Original publication Full text 2015 Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T, Niessen HW, Mizrahi J, Schönfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction Nature medicine 2015;2;2;140-149 Full text Kull S, Schulz KM, Strotmeier JW, Kirchner S, Schreiber T, Bollenbach A, Dabrowski PW, Nitsche A, Kalb SR, Dorner MB, Barr JR, Rummel A, Dorner BG Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype PLoS One 2015;10;2 Full text Rohrbeck A, von Elsner L, Hagemann S, Just I Uptake of Clostridium botulinum C3 exoenzyme into Intact HT22 and J774A.1 Cells Toxins 2015;7;380-395 Full text Bothe M, Dutow P, Pich A, Genth H, Klos A DXD motif-dependent and -independent effects of the Chlamydia trachomatis cytotoxin CT166 Toxins 2015;17;621-637 Full text Hashemi Nassab M, Rhein M, Hagemeier L, Kaeser M, Muschler M, Glahn A, Pich A, Heberlein A, Kornhuber J, Bleich S, Frieling H, Hillemacher T Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients. Eur Addict Res 2016;22(2);59 -69 Full text Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics. Toxicon 2015;107(Pt.A);43 -49 Abstract Reichert O, Kolbe L, Terstegen L, Staeb F, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G UV radiation induces CXCL5 expression in human skin. Exp Dermatol 2015;24(4);309 -312 Full text Rummel A The long journey of botulinum neurotoxins into the synapse. Toxicon 2015;107(Pt.A):9 -24 Abstract Rohrbeck A, Stahl F, Höltje M, Hettwer T, Lindner P, Hagemann S, Pich A, Haastert-Talini K C3-induced release of neurotrophic factors from Schwann cells - potential mechanism behind its regeneration promoting activity Neurochem Int 2015; 90;232 -245 Abstract Schröder A, Rohrbeck A, Just I, Pich A Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme. J Proteome Res 2015;14(11);4721 -4733 Full text Emmrich S, Engeland F, El-Khatib M, Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink M, Klusmann JH miR-139-5p controls translation in myeloid leukemia through EIF4G2. Oncogene 2015;DOI: 10.1038/onc.2015.247 Full text Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H Identification of ageing-associated naturally occurring peptides in human urine. Oncotarget 2015;6(33);34106 -34117 Abstract Saul VV, Niedenthal R, Pich A, Weber F, Schmitz ML SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity. Biochim Biophys Acta 2015;1853(1);136 -143 Full text Weldearegay YB, Pich A, Schieck E, Liljander A, Gicheru N, Wesonga H, Thiaucourt,F, Kiirika LM, Valentin-Weigand P, Jore J, Meens J Proteomic characterization of pleural effusion, a specific host niche of Mycoplasma mycoides subsp. mycoides from cattle with contagious bovine pleuropneumonia (CBPP). J Proteomics 2015. DOI: 10.1016/j.jprot.2015.10.016 Full text Keller B, Mühlenkamp M, Deuschle E, Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jimenez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells. Cell Microbiol 2015;17(8);1179 -1204 Full text Dorner BG, Rummel A Preface biological Toxins ancient molecules posing a current threat. Toxins 2015;7(12);5320 -5321 Full text 2014 Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F. Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca and GTPgammaS ,,Toxicology,2015;328():48-56 Originalpublication Chatterji,B. ; Dickhut,C. ; Mielke,S. ; Krüger,J. ; Just,I. ; Glage,S. ; Meier,M. ; Wedekind,D. ; Pich,A. MALDI imaging mass spectrometry to investigate endogenous peptides in an animal model of Usher's disease , Germany,Proteomics,2014;14(13-14):1674-1687 Originalpublication Dressler,D. ; Adib Saberi,F. ; Bigalke,H. IncobotulinumtoxinA (Xeomin((R))) can produce antibody-induced therapy failure in a patient pretreated with abobotulinumtoxinA (Dysport((R))) Austria,J.Neural Transm.,2014;121(7):769-771 Case report Dressler,D. ; Gessler,F. ; Tacik,P. ; Bigalke,H. An enzyme-linked immunosorbent assay for detection of botulinum toxin-antibodies United States,Mov.Disord.,2014;29(10):1322-1324 Original publication Genth,H. ; Pauillac,S. ; Schelle,I. ; Bouvet,P. ; Bouchier,C. ; Varela-Chavez,C. ; Just,I. ; Popoff,M. R. Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins England,Cell.Microbiol.,2014;16(11):1706-1721 Original publication Gonzalez-Escalona,N. ; Thirunavukkarasu,N. ; Singh,A. ; Toro,M. ; Brown,E. W. ; Zink,D. ; Rummel,A. ; Sharma,S. K. Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type United States,Genome Announc,2014;2(6):10.1128/genomeA.01275-14 Original publication Goy,S. D. ; Olling,A. ; Neumann,D. ; Pich,A. ; Gerhard,R. Human neutrophils are activated by a peptide fragment of Clostridium difficile Toxin B presumably via formyl peptide receptor ,,Cell.Microbiol.,2015;17(6):893-909 Original publication Hardtke-Wolenski,M. ; Taubert,R. ; Noyan,F. ; Sievers,M. ; Dywicki,J. ; Schlue,J. ; Falk,C. S. ; Lundgren,B. A. ; Scott,H. S. ; Pich,A. ; Anderson,M. S. ; Manns,M. P. ; Jaeckel,E. Autoimmune hepatitis in a murine APS-1 model is directed against multiple autoantigens ,,Hepatology,2015;61(4):1295-1305 Original publication Jochim,N. ; Gerhard,R. ; Just,I. ; Pich,A. Time-resolved cellular effects induced by TcdA from Clostridium difficile England,Rapid Commun.Mass Spectrom.,2014;28(10):1089-1100 Original publication Jünger,J. ; Just,I. Recommendations of the German Society for Medical Education and the German Association of Medical Faculties regarding university-specific assessments during the study of human, dental and veterinary medicine Germany,GMS Z.Med.Ausbild,2014;31(3):Doc34- Original publication Konze,S. A. ; van Diepen,L. ; Schröder,A. ; Olmer,R. ; Moller,H. ; Pich,A. ; Weissmann,R. ; Kuss,A. W. ; Zweigerdt,R. ; Buettner,F. F. Cleavage of E-cadherin and beta-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells United States,Mol.Cell.Proteomics,2014;13(4):990-1007 Original publication Lee,K. ; Lam,K. H. ; Kruel,A. M. ; Perry,K. ; Rummel,A. ; Jin,R. High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex United States,Biochem.Biophys.Res.Commun.,2014;446(2):568-573 Original publication Lee,K. ; Zhong,X. ; Gu,S. ; Kruel,A. M. ; Dorner,M. B. ; Perry,K. ; Rummel,A. ; Dong,M. ; Jin,R. Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex United States,Science,2014;344(6190):1405-1410 Original publication Matsui,T. ; Gu,S. ; Lam,K. H. ; Carter,L. G. ; Rummel,A. ; Mathews,I. I. ; Jin,R. Structural Basis of the pH-Dependent Assembly of a Botulinum Neurotoxin Complex England,J.Mol.Biol.,2014;426(22):3773-3782 Originalpublication May,M. ; Schelle,I. ; Brakebusch,C. ; Rottner,K. ; Genth,H. Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry United States,Cell.Cycle,2014;13(14):2211-2221 Original publication Nkuipou-Kenfack,E. ; Koeck,T. ; Mischak,H. ; Pich,A. ; Schanstra,J. P. ; Zürbig,P. ; Schumacher,B. Proteome analysis in the assessment of ageing ,,Ageing Res.Rev.,2014;18C():74-85 Overview Olling,A. ; Hüls,C. ; Goy,S. ; Müller,M. ; Krooss,S. ; Rudolf,I. ; Tatge,H. ; Gerhard,R. The combined repetitive oligopeptides of clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation Switzerland,Toxins (Basel),2014;6(7):2162-2176 Original publication Rohrbeck,A. ; Schröder,A. ; Hagemann,S. ; Pich,A. ; Höltje,M. ; Ahnert-Hilger,G. ; Just,I. Vimentin mediates uptake of C3 exoenzyme United States,PLoS One,2014;9(6):e101071- Original publication Rohrbeck,A. ; von Elsner,L. ; Hagemann,S. ; Just,I. Binding of Clostridium botulinum C3 exoenzyme to intact cells Germany,Naunyn Schmiedebergs Arch.Pharmacol.,2014;387(6):523-532 Original publication Rummel,A. ; The dual receptor recognition of botulinum neurotoxins New York, NY,,2014;4():129-150 Book contribution, monograph Saul,V. V. ; Niedenthal,R. ; Pich,A. ; Weber,F. ; Lienhard Schmitz,M. SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity Netherlands,Biochim.Biophys.Acta,2015;1853(1):136-143 Original publication Strotmeier,J. ; Mahrhold,S. ; Krez,N. ; Janzen,C. ; Lou,J. ; Marks,J. D. ; Binz,T. ; Rummel,A. Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A Netherlands,FEBS Lett.,2014;588(7):1087-1093 Original publication Wagner,S. ; Maibaum,D. ; Pich,A. ; Nolte,I. ; Murua Escobar,H. Verification of a Canine PSMA (FolH1) Antibody Greece,Anticancer Res.,2015;35(1):145-148 Original publication Wohlan,K. ; Goy,S. ; Olling,A. ; Srivaratharajan,S. ; Tatge,H. ; Genth,H. ; Gerhard,R. Pyknotic cell death induced by Clostridium difficile TcdB: Chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity ,,Cell.Microbiol.,2014;76(11):1678-1692 Originalpublication Boetzkes,Alexander Secretome analysis of hypervirulent Clostridium difficile strains ,,,2014;():Getr. count- Dissertation Brandes,Vanessa Phosphorylation of Rac1/Cdc42 mediated by tauroursodeoxycholic acid causes reduced glucosylation catalyzed by C. difficile toxin B ,,,2014;():Bl. 77 - 84, Bl. 11 - 43- Dissertation Goy,Sebastian David Clostridium difficile Toxin B activates formyl peptide receptor 1 of human neutrophil granulocytes via N-terminal glucosyltransferase domain ,,,2014;():138 Bl. Ill., graph. Illustrations - Dissertation Rotsch,Jacqueline Cellular effects of the bacterial exoenzyme C3 bot ,,,2011;():III, 72 Bl. Ill., graph. Fig.- Dissertation Beer,Lara-Antonia The role of the low molecular weight GTpase Rac1 and the NADPH oxidase in Clostridium difficile TcdB-induced pyknosis ,,,2011;():- Master thesis Petersen,Lara The role of Rho-GTPases in the cytopathic and cytotoxic effects of Clostridium difficile toxins ,,,2011;():62 p.- Master thesis Gangl,Anna-Katharina Effects of the marine toxin latrunculin B on the epithelial barrier function of the colon ,,,2011;():37 p.- Bachelor thesis 2013 Bagramyan,K. ; Kaplan,B. E. ; Cheng,L. W. ; Strotmeier,J. ; Rummel,A. ; Kalkum,M. Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples United States,Anal.Chem.,2013;85(11):5569-5576 Original publication Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F. Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialyzed with high free-Ca(2+) and GTPgammaS containing intracellular solution Netherlands,Eur.J.Pharmacol.,2013;720(1-3):227-236 Original publication Barth,H. ; Bigalke,H. ; Gerhard,R. ; Bacterial Toxins (Ch. 42) Stuttgart,,2013;():1157-1180 Book contribution, monograph Bigalke,H. Botulinum toxin: application, safety, and limitations Germany,Curr.Top.Microbiol.Immunol.,2013;364():307-317 Original publication Chatterji,B. ; Pich,A. MALDI imaging mass spectrometry and analysis of endogenous peptides England,Expert Rev.Proteomics,2013;10(4):381-388 Original publication Gerhard,R. ; Frenzel,E. ; Goy,S. ; Olling,A. Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain ,,J.Med.Microbiol.,2013;62(9):1414-1422 Original publication Höltje,M. ; Schulze,S. ; Strotmeier,J. ; Mahrhold,S. ; Richter,K. ; Binz,T. ; Bigalke,H. ; Ahnert-Hilger,G. ; Rummel,A. Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons ,,Toxicon,2013;75C():108-121 Original publication Huelsenbeck,S. C. ; Roggenkamp,D. ; May,M. ; Huelsenbeck,J. ; Brakebusch,C. ; Rottner,K. ; Ladwein,M. ; Just,I. ; Fritz,G. ; Schmidt,G. ; Genth,H. Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1 Netherlands,Int.J.Biochem.Cell Biol.,2013;45(8):1767-1775 Original publication Lee,K. ; Gu,S. ; Jin,L. ; Le,T. T. ; Cheng,L. W. ; Strotmeier,J. ; Kruel,A. M. ; Yao,G. ; Perry,K. ; Rummel,A. ; Jin,R. Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity United States,PLoS Pathog.,2013;9(10):e1003690- Original publication Mahrhold,S. ; Strotmeier,J. ; Garcia-Rodriguez,C. ; Lou,J. ; Marks,J. D. ; Rummel,A. ; Binz,T. Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E England,Biochem.J.,2013;453(1):37-47 Original publication May,M. ; Wang,T. ; Müller,M. ; Genth,H. Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470 Switzerland,Toxins (Basel),2013;5(1):106-119 Original publication Pirazzini,M. ; Henke,T. ; Rossetto,O. ; Mahrhold,S. ; Krez,N. ; Rummel,A. ; Montecucco,C. ; Binz,T. Neutralization of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain Netherlands,FEBS Lett.,2013;587(23):3831-3836 Original publication Rangrez,A. Y. ; Bernt,A. ; Poyanmehr,R. ; Harazin,V. ; Boomgaarden,I. ; Kuhn,C. ; Rohrbeck,A. ; Frank,D. ; Frey,N. Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy United States,J.Cell Biol.,2013;203(4):643-656 Original publication Rummel,A. Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity Germany,Curr.Top.Microbiol.Immunol.,2013;364():61-90 Original publication Scherr,M. ; Elder,A. ; Battmer,K. ; Barzan,D. ; Bomken,S. ; Ricke-Hoch,M. ; Schröder,A. ; Venturini,L. ; Blair,H. J. ; Vormoor,J. ; Ottmann,O. ; Ganser,A. ; Pich,A. ; Hilfiker-Kleiner,D. ; Heidenreich,O. ; Eder,M. ; Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL positive B-lineage acute lymphoblastic leukemia ,,Leukemia,2014;28(3):554-565 Original publication Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P. The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases United States,PLoS Pathog.,2013;9(11):e1003746- Original publication Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P. The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases United States,PLoS Pathog.,2013;9(11):e1003746- Original publication Steffen,A. ; Ladwein,M. ; Dimchev,G. A. ; Hein,A. ; Schwenkmezger,L. ; Arens,S. ; Ladwein,K. I. ; Holleboom,J. M. ; Schur,F. ; Small,J. V. ; Schwarz,J. ; Gerhard,R. ; Faix,J. ; Stradal,T. E. ; Brakebusch,C. ; Rottner,K. Rac function is critical for cell migration but not required for spreading and focal adhesion formation ,,J.Cell.Sci.,2013;126(Pt.20):4572-4588 Originalpublication Stevens,G. B. ; Silver,D. A. ; Zgaga-Griesz,A. ; Bessler,W. G. ; Vashist,S. K. ; Patel,P. ; Achazi,K. ; Strotmeier,J. ; Worbs,S. ; Dorner,M. B. ; Dorner,B. G. ; Pauly,D. ; Rummel,A. ; Urban,G. A. ; Krueger,M. Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity ,,Analyst,2013;138(20):6154-6162 Original publication Willjes,G. ; Mahrhold,S. ; Strotmeier,J. ; Eichner,T. ; Rummel,A. ; Binz,T. Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity United States,Biochemistry,2013;52(22):3930-3938 Original publication Zeiser,J. ; Gerhard,R. ; Just,I. ; Pich,A. Substrate Specificity of Clostridial Glucosylating Toxins and Their Function on Colonocytes Analyzed by Proteomics Techniques ,,J.Proteome Res.,2013;12(4):1604-1618 Originalpublication Völker,Anne Katrin Identification and characterization of the receptor binding pockets of botulinum neurotoxin serotype D (BoNTD) ,,,2013;():Getr. count Ill., graph. Illustrations - Dissertation Benski,Anastasia ; Analysis of C3bot exoenzyme-dependent ADP-ribosylation of smal Rho-GTPases by Mass Spectrometry ,,,2013;():- Master thesis Hüls,Corinna Intracellular association of functional domains of Clostridium difficile toxin A ,,,2013;():- Master thesis Raasch,Sabine Inhibition of clostridial glucosylating toxins by tauro- and glucoconjugated bile acids ,,,2013;():- Master thesis Ulfig,Anneli Investigation of endogenous peptides in rat brain using MALDI Imaging and LC-MS ,,,2013;():- Master thesis Völkening,Lea Neutralizing effect of tauro- and glycoconjugated bile acids on Clostridium difficile toxin B ,,,2013;():- Master thesis Wohlan,Katharina Rho-dependent and independent effect of Clostridium difficile toxin B on the cell cycle ,,,2013;():- Master thesis Bollenbach,Alexander Identification of the activity-reducing amino acids of botulinum neurotoxin subtypes A4 and A8 (Chemnitz strain) ,,,2012;():- Bachelor thesis Weigt,David The effect of cytotoxic necrotizing factors from Yersinia pseudotuberculosis and Escherichia coli on the epithelial barrier function of cultured renal epithelial cells ,,,2012;():- Bachelor thesis 2012 Auer M, Schweigreiter R, Hausott B, Thongrong S, Höltje M, Just I, Bandtlow C, Klimaschewski L. Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons. Front Cell Neurosci 2012;6;43 Original publication Baron,J. ; Blex,C. ; Rohrbeck,A. ; Rachakonda,S. K. ; Birnbaumer,L. ; Ahnert-Hilger,G. ; Brunk,I. The alpha-subunit of the trimeric GTPase Go2 regulates axonal growth ,,J.Neurochem.,2013;124(6):782-794 Original publication Bigalke H, Frevert J. Botulinum toxin A: dose and immune response. Int J Rehabil Res 2012;35(2);93 Original publication Boetzkes,A. ; Felkel,K. W. ; Zeiser,J. ; Jochim,N. ; Just,I. ; Pich,A. Secretome analysis of Clostridium difficile strains Germany,Arch.Microbiol.,2012;194(8):675-687 Original publication Brandes V, Schelle I, Brinkmann S, Schulz F, Schwarz J, Gerhard R, Genth H. Protection from C. difficile Toxin B-catalyzed Rac/Cdc42 glucosylation by tauroursodeioxycholic acid-induced Rac/Cdc42 phosphorylation. Biol Chem 2012;1;393(1-2);77-84 Original publication Chiaradia,E. ; Avellini,L. ; Tartaglia,M. ; Gaiti,A. ; Just,I. ; Scoppetta,F. ; Czentnar,Z. ; Pich,A. Proteomic evaluation of sheep serum proteins England,BMC Vet.Res.,2012;8():66- Original publication Debez,A. ; Braun,H. P. ; Pich,A. ; Taamalli,W. ; Koyro,H. W. ; Abdelly,C. ; Huchzermeyer,B. Proteomic and physiological responses of the halophyte Cakile maritima to moderate salinity at the germinative and vegetative stages Netherlands,J.Proteomics,2012;75(18):5667-5694 Original publication Gu,S. ; Rumpel,S. ; Zhou,J. ; Strotmeier,J. ; Bigalke,H. ; Perry,K. ; Shoemaker,C. B. ; Rummel,A. ; Jin,R. Botulinum neurotoxin is shielded by NTNHA in an interlocked complex United States,Science,2012;335(6071):977-981 Original publication Hammerschmidt,A. ; Chatterji,B. ; Zeiser,J. ; Schröder,A. ; Genieser,H. G. ; Pich,A. ; Kaever,V. ; Schwede,F. ; Wolter,S. ; Seifert,R. Binding of Regulatory Subunits of Cyclic AMP-Dependent Protein Kinase to Cyclic CMP Agarose United States,PLoS One,2012;7(7):e39848- Original publication Hefter,H. ; Hartmann,C. ; Kahlen,U. ; Moll,M. ; Bigalke,H. Prospective analysis of neutralising antibody titres in secondary non-responders under continuous treatment with a botulinumtoxin type A preparation free of complexing proteins--a single cohort 4-year follow-up study England,BMJ Open,2012;2(4):10.1136/bmjopen-2011-000646. Print 2012 Original publication Huelsenbeck,J. ; May,M. ; Schulz,F. ; Schelle,I. ; Ronkina,N. ; Hohenegger,M. ; Fritz,G. ; Just,I. ; Gerhard,R. ; Genth,H. Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin Netherlands,FEBS Lett.,2012;586(20):3665-3673 Original publication Hülsenbeck SC, Rohrbeck A, Handreck A, Hellmich G, Kiaei E, Roettinger I, Grothe C, Just I, Haastert-Tallini K. C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury Neurotherapeutics 2012;9;185-198 Original publication Katsch,K. ; de Jong,S. J. ; Albrecht,J. C. ; Steger,J. ; Genth,H. ; Posern,G. ; Biesinger,B. Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip England,Cell.Commun.Signal.,2012;10(1):5-811X-10-5 Original publication May,M. ; Kolbe,T. ; Wang,T. ; Schmidt,G. ; Genth,H. Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis United States,J.Signal.Transduct,2012;2012():570183- Original publication Olling A, Seehase S, Minton NP, Tatge H, Schröter S, Kohlscheen S, Pich A, Just I, Gerhard R. Release of TcdA and TcdB from Clostridium cdi 630 is not affected by functional inactivation of the tcdE gene. Microb Pathog 2012;52(1);92-100 Original publication Rohrbeck,A. ; Kolbe,T. ; Hagemann,S. ; Genth,H. ; Just,I. Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q England,FEBS J.,2012;279(15):2657-2671 Original publication Rotsch J, Rohrbeck A, May M, Kolbe T, Hagemann S, Schelle I, Just I, Genth H, Huelsenbeck SC. Inhibition of macrophage migration by C. botulinum exoenzyme C3 Naumyn-Schmiedebergs's Arch Pharmacol 2012;385(9);883-90. May29 [Epub ahead of print] Original publication Schwarz,J. ; Proff,J. ; Hävemeier,A. ; Ladwein,M. ; Rottner,K. ; Barlag,B. ; Pich,A. ; Tatge,H. ; Just,I. ; Gerhard,R. Serine-71 phosphorylation of rac1 modulates downstream signaling United States,PLoS One,2012;7(9):e44358- Original publication Strotmeier,J. ; Willjes,G. ; Binz,T. ; Rummel,A. Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity Netherlands,FEBS Lett.,2012;586(4):310-313 Original publication Weigoldt,M. ; Meens,J. ; Bange,F. C. ; Pich,A. ; Gerlach,G. F. ; Goethe,R. Metabolic adaptation of Mycobacterium avium subsp. paratuberculosis to the gut environment ,,Microbiology,2013;159(Pt.2):380-391 Original publication Wellhöner,H. ; Weiss,A. ; Schulz,A. ; Adermann,K. ; Braitbard,O. ; Bar-Sinai,A. ; Hochman,J. Reversing ABCB1-mediated multi-drug resistance from within cells using translocating immune conjugates England,J.Drug Target.,2012;20(5):445-452 Original publication Euler,Friederike Christina Significance of autoproteolysis for the intracellular effect of Clostridium difficile toxin A ,,,2011;():50 Bl.- Dissertation Fritsch,Cornelia Binding and uptake of Clostridium botulinum C3 exoenzyme in F98 cells ,,,2012;():97 Bl.- Dissertation Janzen,Constantin Identification of the SV2 binding pocket in the H CC domain of botulinum neurotoxin serotype A ,,,2012;():[2], 73 Bl.- Dissertation Lica,Marta Anna Differences in the biological effect of Clostridium difficile toxin B in proliferating and non-proliferating cells ,,,2011;():[1], 275-283, 10-25 Bl.- Dissertation Roggenkamp,Dennis Functional characterization of the interaction of skin cells and neuronal cells in healthy and stressed skin ,,,2011;():VI p., p. 7-94, IV p.- Dissertation Schröder,Anke Effects of the C3 exoenzyme from Clostridium botulinum on the proteome of murine hippocampal cells ,,,2012;():VI, 107 p. Ill., graph. Fig.- Dissertation Zeiser,Johannes The substrate spectrum of clostridial glucosylating toxins and the effects on the proteome of colonocytes ,,,2012;():[7], 3 - 106, [20] Bl.- Dissertation Brinkmann,Sophie Cdk 1 dependent phosphorylation of the Rac GEF protein beta-Pix ,,,2012;():- Master thesis Doberenz,Sebastian ; Kinetic analysis of toxin A-mediated glucosylation of small GTPases ,,,2012;():- Master thesis Edeling,Maria Functional characterization of renal tubular cells in a model for diabetic nephropathy ,,,2012;():- Master thesis Findeisen,Katja Neutralization of Clostridium difficile toxin B by tauro-conjugated bile acids ,,,2012;():- Master thesis Krüger,Jonas Ribosomal proteome analysis of C3 exoenzyme-treated cells ,,,2012;():- Master thesis Nolte,Annika The Rac1-induced upregulation of Frizzled receptors ,,,2012;():- Master thesis Rataj,Dennis Involvement of CIC-5 in the cellular uptake of the clostridial toxins TcdA and TcdA1-1874 ,,,2012;():- Master thesis 2011 Boer U, Lohrenz A, Klingenberg M, Pich A, Haverich A, Wilhelmi M. The effect of detergent-based decellularization procedures on cellular proteins and immunogenicity in equine carotid artery grafts. Biomaterials 2011;32;9730-9737 Original publication Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, Schulz TF, Jacobs R, Messerle M, Kay-Federov PC. The Human Cytomegalovirus UL11 Protein Interacts with the Receptor Tyrosine Phosphatase CD45, Resulting in Functional Paralysis of T Cells.PLoS Pathog 2011;7(12) Original publication Gerhard R, Queißer S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I. Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B Naunyn Schmiedebergs Arch Pharmacol 2011;383;285-295 Original publication Höltje M, Just I, Ahnert-Hilger G. Clostridial C3 proteins: Recent approaches to improve neuronal growth and regeneration. Ann Anat 2011;193(4);314-320 Original publication Jochim N, Gerhard R, Just I, Pich A. Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotype-coded protein labeling and LC-MALDI. Proteome Sci 2011;9;48 Original publication Lica M, Schulz F, Schelle I, May M, Just I, Genth H. Difference in the biological effects of Clostridium difficile B in profilerating and non-proliferating cells. Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);275-283 Original publication Mueller MQ, Zeiser JJ, Dreiocker F, Pich A, Schaefer M, Sinz A. An universal matrix-assisted laser desorption/ionization cleavable cross-linker for protein structure analysis. Rapid Commun Mass Spectrom 2011;25(1);155-161 Original publication Nölle A, Zeug A, van Bergeijk, Tönges L, Gerhard R, Brinkmann H, Al Rayes S, Hensel N, Schill Y, Apkhazava D, Jablonka S, Omer J, Srivastrav RK, Baasner A, Lingor P, Wirth B, Ponimaskin E, Niedenthal R, Grothe C, Claus P. The Spinal Muscular Atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin. Human molecular genetics 2011;15;20(24);4865-4878 Original publication Olling A, Goy S, Hoffmann F, Tatge H, Just I, Gerhard R. The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A. PLoS One 2011;18;6(3) e17623 Original publication Oumeraci T, Schmidt B, Wolf T, Zapatka M, Pich A, Brors B, Eils R, Fleischhacker M, Schlegelberger B, v. Neuhoff N. Bronchoalveolar lavage fluid of lung cancer patients: mapping the uncharted waters using proteomics technology. Lung Cancer 2011;72(1);136-138 Original publication Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grünwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gönczy P, Malek NP. The SCF-Fbxw5 E3-ubiquitin ligase is regulated by Plk4 and targets HsSAS-6 to control centrosome duplication. Nat Cell Biol 2011;13(8);1004-1009 Original publication Rost BR, Nicholson P, Ahnert-Hilger G, Rummel A, Rosenmund C, Breustedt J, Schmitz D. Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion. J Cell Science 2011;15;124(Pt18);3066-73 Original publication Rummel A, Mahrhold S, Bigalke H, Binz T. Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin. FEBS J 2011;278(23);4506-4515 Original publication Rummel,A. Molecular biology of Clostridium botulinum organism and botulinum neurotoxins, insight into the molecular machinery involved in Clostridium botulinum neurotoxity ,Hauppauge, N.Y.,,2011;():37-70 Book contribution, monograph Rummel,A. ; Mahrhold,S. ; Bigalke,H. ; Binz,T. Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin ,,FEBS J.,2011;278(23):4506-4515 10.1111/j.1742-4658.2011.08196.x Original publication Schacht T, Unger C, Pich A, Wydra K. Endo- and exopolygalacturonases of Ralstonia solanacearum are inhibited by polygalacturonase-inhibiting protein (PGIP) activity in tomato stem extracts. Plant Physiol Biochem 2011;49(4);377-387 Original publication Schulte-Baukloh H, Herholz J, Bigalke H, Miller K, Knispel HH. Results of a BoNT/A Antibody Study in Children and Adolescents after Onabotulinumtoxin A (Botox(R)) Detrusor Injection. Urol Int 2011;87(4);434-438 Original publication Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T. The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites. Mol Microbiol 2011;81(1);143-156 Original publication Wolf T, Oumeraci T, Gottlieb J, Pich A, Brors B, Eils R, Haverich A, Schlegelberger B, Welte T, Zapatka M, von Neuhoff N. Proteomic Bronchiolitis Obliterans Syndrome Risk Monitoring in Lung Transplant Recipients. Transplantation 2011;92(4);477-485 Original publication Zeiser J, Klodmann J, Braun HP, Gerhard R, Just I, Pich A. Effects of Clostridium difficile Toxin A on the proteome of colonocytes studied by differential 2D electrophoresis. Journal of Proteomics 2011;75;469-479 Original publication Felkel,Katharina-Wiebke LC-MS based secretome analysis of different Clostridium difficile strains ,,,2010;():104 Bl.- Dissertation Halabi Cabezon,Ismael Abrogation of the cytopathic effect of Clostridium difficile toxin B by Rac1 activation ,,,2010;():3751-3756, 7-20 Bl.- Dissertation Jochim,Nelli LC-MS-based global proteome analysis of colon cells after treatment with clostridial glucosylating toxins ,,,2011;():XVII, 124 Bl.- Dissertation Kreimeyer,Isa The autoproteolytic cleavage influences the cytotoxic effect of Clostridium difficile toxin A ,,,2010;():36 Bl.- Dissertation Lücke,Nina Secretome analysis of the hematopoietic progenitor cell line DKmix ,,,2010;():46 Bl.- Dissertation May,Martin Role of Rac1 and PAK in the regulation of G2-M transition and mitotic cell rounding ,,,2011;():[7], 79 Bl.- Dissertation Schrader,Merle Correlation of C. difficile toxin A-induced apoptosis with the upregulation of the GTP-binding protein RhoB ,,,2011;():62 Bl.- Dissertation Werner,Stefan Characterization of the cellular uptake of C. botulinum C3 exoenzyme ,,,2010;():[3], 86 Bl.- Dissertation Dickhut,Clarissa Imaging mass spectrometry for the histological analysis of tissues ,,,2010;():- Master thesis Frenzel,Eileen Characterization of the cellular uptake of the C. difficile toxins TcdA and TcdA1-1874 ,,,2010;():- Master thesis Lentes,Jana Effects of GTP loading on the glucosylation of Rho proteins by Clostridia toxins ,,,2011;():- Bachelor thesis 2010 Adler,S. ; Bicker,G. ; Bigalke,H. ; Bishop,C. ; Blumel,J. ; Dressler,D. ; Fitzgerald,J. ; Gessler,F. ; Heuschen,H. ; Kegel,B. ; Luch,A. ; Milne,C. ; Pickett,A. ; Ratsch,H. ; Ruhdel,I. ; Sesardic,D. ; Stephens,M. ; Stiens,G. ; Thornton,P. D. ; Thürmer,R. ; Vey,M. ; Spielmann,H. ; Grune,B. ; Liebsch,M. The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting England,Altern.Lab.Anim.,2010;38(4):315-330 Original publication Backert S, Kenny B, Gerhard R, Tegtmeyer N, Bran S. PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463: A novel pathway in regulating Rac1 GTPase function. Gut Microbes 2010;1(2);94-99 Original publication Dahal,D. ; Pich,A. ; Braun,H. P. ; Wydra,K. Analysis of cell wall proteins regulated in stem of susceptible and resistant tomato species after inoculation with Ralstonia solanacearum: a proteomic approach Netherlands,Plant Mol.Biol.,2010;73(6):643-658 10.1007/s11103-010-9646-z Original publication Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, Bigalke H, Suckling J, Ushkaryov Y, Naumenko N, Shakirzyanova A, Giniatullin R, Maywood E, Hastings M, Binz T, Davletov B. SNARE tagging allows stepwise assembly of a multimodular medicinal toxin. Proc Natl Acad Sci USA 2010;107(42);18197-18201 Original publication Genth H, Just I. Functional implications of lethal toxin-catalyzed glucosylation of (H/K/N)Ras and Rac1 in Clostridium sordellii-associated disease. Eur J Cell Biol 2010;12(4);Epub ahead of print Original publication Genth H, Schulz F, Just I. Gluscosylation of Rho/Ras Proteins by Lethal Toxin - Implication of Actin Re-Organization and Apoptosis in C. Sordellii-Associated Disease. Open Toxinology 2010;3;13-18 Original publication Just I, Hülsenbeck SC, Genth H. Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and a Neurotrophic Agent. Open Toxinology 2010;3;19-23 Original publication Just I, Rohrbeck A, Huelsenbeck SC, Hoeltje M. Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);247-52; Epub 2010 Review Kreimeyer I, Euler F, Marckscheffel A, Tatge H, Pich A, Olling A, Schwarz J, Just I, Gerhard R. Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A. Naunyn Schmiedebergs Arch Pharmacol 2010;11(3); Epub 2010 Original publication Krückeberg J, Just I, Möbs D, Matthies H, Fischer V. Added value recognized, deficits eliminated? - Quantitative analysis of electronically written exams at Hannover Medical School. GMA [ed:] Annual conference of the Society for Medical Education (GMA). Bochum, 23-25.09.2010 Lecture Luecke N, Templin C, Muetzelburg MV, Neumann D, Just I, Pich A. Secreted proteome of the murine multipotent hematopoietic progenitor cell line DKmix. Rapid Commun Mass Spectrom 2010;24(5);561-570 Original publication Naue N, Fedorov R, Pich A, Manstein DJ, Curth U. Site-directed mutagenesis of the {chi} subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction. Nucleic Acids Res 2010;23(10); Epub ahead of print Original publication Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R. Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner. Biochem J 2010;431(2):207-216 Original publication Thalmann J, Janik K, May M, Sommer K, Ebeling J, Hofmann F, Genth H, Klos A. Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. PLoS One 2010;5(3) Original publication Häfner,Kirstin Competition experiments on the mouse hemidiaphragm assay for the identification of protein receptors of clostridial neurotoxins: SV2 mediates the uptake of BoNT/F into neuronal cells ,,,2010;():- Dissertation Lange,Oliver Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A : much ado about nothing? ,,,2010;():213 - 218, 16 Bl.- Dissertation Nottrott,Stefanie Clostridium difficile toxin A-induced apoptosis is independent of p53 but dependent on glucosylation of Rho-GTPases ,,,2010;():[1], 33 Bl.- Dissertation Supthut,Hauke Intra- and extracellular factors determining the sensitivity of CHO cells to Clostridium difficile toxin B ,,,2009;():89 Bl.- Dissertation Barlag,Britta Involvement of IQGAP and MRCK in phospho-Rac1-mediated filopodia formation ,,,2010;():- Master thesis Goy,Sebastian Significance of the receptor binding domain of Clostridium difficile toxin A for functionality ,,,2010;():- Master thesis Kolbe,Tanja Effect of Rho-modified bacterial toxins in an in vitro model of wound healing ,,,2010;():- Diploma thesis Wang,Tianbang F-actin depolymerization by clostridial toxins ,,,2010;():- Diploma thesis 2009 Andresen,H. ; Bingel,U. ; Streichert,T. ; Schmoldt,A. ; Zoerner,A. A. ; Tsikas,D. ; Just,I. Severe glycerol intoxication after Meniere's disease diagnosis--case report and overview of kinetic data England,Clin.Toxicol.(Phila),2009;47(4):312-316 10.1080/15563650902849123 Original publication Binz,T. ; Rummel,A. Cell entry strategy of clostridial neurotoxins England,J.Neurochem.,2009;109(6):1584-1595 10.1111/j.1471-4159.2009.06093.x Original publication Brunger,A. T. ; Rummel,A. Receptor and substrate interactions of clostridial neurotoxins England,Toxicon,2009;54(5):550-560 10.1016/j.toxicon.2008.12.027 Original publication Deplazes,J. ; Fuchs,M. ; Rauser,S. ; Genth,H. ; Lengyel,E. ; Busch,R. ; Luber,B. ; Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation England,Hum.Mol.Genet.,2009;18(19):3632-3644 10.1093/hmg/ddp312 Original publication Dreger,S. C. ; Schulz,F. ; Huelsenbeck,J. ; Gerhard,R. ; Hofmann,F. ; Just,I. ; Genth,H. Killing of Rat Basophilic Leukemia Cells by Lethal Toxin from Clostridium sordellii: Critical Role of Phosphatidylinositide 3'-OH Kinase/Akt Signaling (dagger) ,,Biochemistry,2009;():- 10.1021/bi800708b Original publication Genth H, Schulz F, Just I. Glucosylation of Rho/Ras Proteins by Lethal Toxin - Implications of Actin-Re-Organization and Apoptosis in C. Sordellii-Associated Disease. The Open Toxinology Journal 2009;2 Abstract Huelsenbeck,S. C. ; Klose,I. ; Reichenbach,M. ; Huelsenbeck,J. ; Genth,H. Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalyzed by Clostridium sordellii lethal toxin Netherlands,FEBS Lett.,2009;583(19):3133-3139 10.1016/j.febslet.2009.09.006 Original publication Huelsenbeck,S. C. ; May,M. ; Schmidt,G. ; Genth,H. Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors--reinforcing the critical role of RhoA in cytokinesis United States,Cell Motil.Cytoskeleton,2009;66(11):967-975 10.1002/cm.20390 Original publication Just I, Hülsenbeck SC, Genth H. Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and an Neurothrophic Agent. The Open Toxinology Journal 2009;2 Abstract Kotz,A. ; Wagener,J. ; Engel,J. ; Routier,F. ; Echtenacher,B. ; Pich,A. ; Rohde,M. ; Hoffmann,P. ; Heesemann,J. ; Ebel,F. The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity ,,Fungal Genet.Biol.,2010;47(2):169-178 10.1016/j.fgb.2009.10.001 Original publication Lange,O. ; Bigalke,H. ; Dengler,R. ; Wegner,F. ; deGroot,M. ; Wohlfarth,K. Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A: much ado about nothing? United States,Clin.Neuropharmacol.,2009;32(4):213-218 10.1097/WNF.0b013e3181914d0a Originalpublikation Mohammadi,B. ; Buhr,N. ; Bigalke,H. ; Krampfl,K. ; Dengler,R. ; Kollewe,K. A long-term follow-up of botulinum toxin A in cervical dystonia ,,Neurol.Res.,2009;31(5):463-466 10.1179/174313209X405137 Original publication Mohammadi,B. ; Kollewe,K. ; Wegener,M. ; Bigalke,H. ; Dengler,R. Experience with long-term treatment with albumin-supplemented botulinum toxin type A Austria,J.Neural Transm.,2009;116(4):437-441 10.1007/s00702-009-0200-6 Original publication Nerlich,A. ; Rohde,M. ; Talay,S. R. ; Genth,H. ; Just,I. ; Chhatwal,G. S. Invasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a phosphatidylinositol 3-kinase-independent mechanism United States,J.Biol.Chem.,2009;284(30):20319-20328 10.1074/jbc.M109.016501 Original publication Rummel,A. ; Häfner,K. ; Mahrhold,S. ; Darashchonak,N. ; Holt,M. ; Jahn,R. ; Beermann,S. ; Karnath,T. ; Bigalke,H. ; Binz,T. Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilizing the three isoforms of SV2 as second receptor England,J.Neurochem.,2009;110(6):1942-1954 10.1111/j.1471-4159.2009.06298.x Original publication Schoentaube,J. ; Olling,A. ; Tatge,H. ; Just,I. ; Gerhard,R. Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A ,,Cell.Microbiol.,2009;11(12):1816-1826 10.1111/j.1462-5822.2009.01373.x Original publication Schulz,F. ; Just,I. ; Genth,H. Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid United States,Biochemistry,2009;48(38):9002-9010 10.1021/bi900964c Original publication Sun,X. ; He,X. ; Tzipori,S. ; Gerhard,R. ; Feng,H. Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages England,Microb.Pathog.,2009;46(6):298-305 10.1016/j.micpath.2009.03.002 Original publication von Witzendorff,D. ; Maass,K. ; Pich,A. ; Ebeling,S. ; Kölle,S. ; Kochel,C. ; Ekhlasi-Hundrieser,M. ; Geyer,H. ; Geyer,R. ; Töpfer-Petersen,E. Characterization of the acidic N-linked glycans of the zona pellucida of prepuberal pigs by a mass spectrometric approach Netherlands,Carbohydr.Res.,2009;344(12):1541-1549 10.1016/j.carres.2009.05.002 Originalpublication Goltz,Björn Tetanus toxin and botulinum toxin A : Interaction with mast cells from the rat peritoneal cavity ,,,2008;():IV, 140 p.- Dissertation Teichert,Matthias Characterization of mutated Clostridium difficile toxin A for the determination of glucosyltransferase-dependent effects ,,,2007;():11 p.- Dissertation 2008 Busche,S. ; Descot,A. ; Julien,S. ; Genth,H. ; Posern,G. Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signaling England,J.Cell.Sci.,2008;121(Pt 7):1025-1035 10.1242/jcs.014456 Original publication Genth,H. ; Dreger,S. C. ; Huelsenbeck,J. ; Just,I. Clostridium difficile toxins: More than mere inhibitors of Rho proteins England,Int.J.Biochem.Cell Biol.,2008;40(4):592-597 10.1016/j.biocel.2007.12.014 Original publication Gerhard,R. ; Nottrott,S. ; Schoentaube,J. ; Tatge,H. ; Olling,A. ; Just,I. Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells England,J.Med.Microbiol.,2008;57(Pt 6):765-770 10.1099/jmm.0.47769-0 Original publication Halabi-Cabezon,I. ; Huelsenbeck,J. ; May,M. ; Ladwein,M. ; Rottner,K. ; Just,I. ; Genth,H. Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1 Netherlands,FEBS Lett.,2008;582(27):3751-3756 10.1016/j.febslet.2008.10.003 Original publication Hoffmann,A. ; Hofmann,F. ; Just,I. ; Lehnardt,S. ; Hanisch,U. K. ; Brück,W. ; Kettenmann,H. ; Ahnert-Hilger,G. ; Höltje,M. Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia United States,Glia,2008;56(11):1162-1175 10.1002/glia.20687 Original publication Höltje,M. ; Djalali,S. ; Hofmann,F. ; Münster-Wandowski,A. ; Hendrix,S. ; Boato,F. ; Dreger,S. C. ; Grosse,G. ; Henneberger,C. ; Grantyn,R. ; Just,I. ; Ahnert-Hilger,G. A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation ,,FASEB J.,2009;23(4):1115-1126/10.1096/fj.08-116855 Original publication Höltje,M. ; Hofmann,F. ; Lux,R. ; Veh,R. W. ; Just,I. ; Ahnert-Hilger,G. Glutamate uptake and release by astrocytes are enhanced by Clostridium botulinum C3 protein United States,J.Biol.Chem.,2008;283(14):9289-9299 10.1074/jbc.M706499200 Original publication Kamanova,J. ; Kofronova,O. ; Masin,J. ; Genth,H. ; Vojtova,J. ; Linhartova,I. ; Benada,O. ; Just,I. ; Sebo,P. Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling United States,J.Immunol.,2008;181(8):5587-5597 Original publication Klisch,K. ; Jeanrond,E. ; Pang,P. C. ; Pich,A. ; Schuler,G. ; Dantzer,V. ; Kowalewski,M. P. ; Dell,A. A tetraantennary glycan with bisecting N-acetylglucosamine and the Sd(a) antigen is the predominant N-glycan on bovine pregnancy-associated glycoproteins England,Glycobiology,2008;18(1):42-52 10.1093/glycob/cwm113 Original publication Kühnel,T. S. ; Schulte-Mattler,W. ; Bigalke,H. ; Wohlfarth,K. Treatment of habitual snoring with botulinum toxin: a pilot study ,,Sleep Breath,2008;12(1):63-68 10.1007/s11325-007-0136-8 Original publication Muetzelburg,M. V. ; Hofmann,F. ; Just,I. ; Pich,A. Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis ,,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2009;877(13):1344-1351 10.1016/j.jchromb.2008.12.005 Original publication Neumann,D. ; Kollewe,C. ; Pich,A. ; Cao,P. ; Resch,K. ; Martin,M. U. Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation United States,J.Leukoc.Biol.,2008;84(3):807-813 10.1189/jlb.0507290 Original publication Sander,L. E. ; Frank,S. P. ; Bolat,S. ; Blank,U. ; Galli,T. ; Bigalke,H. ; Bischoff,S. C. ; Lorentz,A. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells Germany,Eur.J.Immunol.,2008;38(3):855-863 10.1002/eji.200737634 Original publication Schulte-Baukloh,H. ; Bigalke,H. ; Miller,K. ; Heine,G. ; Pape,D. ; Lehmann,J. ; Knispel,H. H. Botulinum neurotoxin type A in urology: antibodies as a cause of therapy failure Australia,Int.J.Urol.,2008;15(5):407-15; discussion 415 10.1111/j.1442-2042.2008.02016.x Original publication Stolz,A. ; Haines,N. ; Pich,A. ; Irvine,K. D. ; Hokke,C. H. ; Deelder,A. M. ; Gerardy-Schahn,R. ; Wuhrer,M. ; Bakker,H. Distinct contributions of beta4GalNAcTA and beta4GalNAcTB to Drosophila glycosphingolipid biosynthesis United States,Glycoconj.J.,2008;25(2):167-175 10.1007/s10719-007-9069-5 Original publication Tschernig,T. ; Neumann,D. ; Pich,A. ; Dorsch,M. ; Pabst,R. Experimental bronchial asthma - the strength of the species rat Netherlands,Curr.Drug Targets,2008;9(6):466-469 Original publication 2007 Conrad S, Genth H, Hofmann F, Just I, Skutella T. Neogenin-RGMa signaling at the growth cone Is BMP-independent and involves RhoA, rock and PKC. J Biol Chem 2007;282(22);16423-33 Abstract Fessler MB, Arndt PG, Just I, Nick JA, Malcolm KC, Worthen GS. Dual role for RhoA in suppression and induction of cytokines in the human neutrophil. Blood 2007;109(3);1248-1256 Abstract Frommberger M, Zürbig P, Jantos J, Krahn T, Mischak H, Pich A, Just I,Schmitt-Kopplin P, Schiffer E. Peptidomic analysis of rat urine using capillary electrophoresis coupled to mass spectrometry. Proteomics 2007;1(7);650-60 Abstract Huelsenbeck J, Dreger S, Gerhard R, Barth H, Just I, Genth H. Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470. Inf Immun 2007;75(2);801-809 Abstract Huelsenbeck J, Dreger S, Gerhard R, Fritz G, Just I, Genth H. Up-regulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile. Biochemistry 2007;24;46(16);4923-31 Abstract Jin R, Sikorra S, Stegmann CM, Pich A, Binz T, Brunger AT. Neurotoxin serotype C1 light chain protease: implications for dual substrate specificity. Biochemistry 2007;46;10685-93 Abstract Klisch K, Jeanrond E, Pang PC, Pich A, Schuller G, Dantzer V, Kowalewski MP, Dell A. A tetraantennary glycan with bisecting N-acetylglucosamine and Sda antigen is the predominant N-glycan on bovine Pregnancy-associated glycoproteins. Glycobiology 2008;18(1);42-52; Epub 2007 Abstract Meyer GK, Neetz A, Brandes G, Tsikas D, Butterfield JH, Just I, Gerhard R. Clostridium difficile Toxin A and B directly stimulate human mast cells. Inf Immun 2007;21(5) Abstract Nottrott S, Schoentaube J, Genth H, Just I, Gerhard R. Apoptosis induced by Clostridium difficile Toxin A is p53-independent and triggered by glucosylation of Rho GTPases. Apoptosis 2007;12(8);1443-53 Abstract Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A, Mahrhold S, Sandhoff K, Proia RL, Acharya KR, Bigalke H, Binz T. Identification of the receptor binding site of botulinum neurotoxins B and G proves the double receptor concept. PNAS 2007;104;359-364 Abstract Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M, Bakker H. Distinct contributions of β4GalNAcTA and β4GalNAcTB to Drosophila glycospingolipid biosynthesis. Glycoconj J 2008;25(2);167-75; Epub 2007 Abstract 2006 Foster K, Bigalke H, Aoki R. Botulinum Neurotoxin - From Laboratory to Bedside Neurotoxicity Research 2006;9;133-140 Abstract Genth H, Huelsenbeck J, Hartmann B, Hofmann F, Just I, Gerhard R. Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B. FEBS Lett 2006;580;3565-3569 Abstract Giesemann T, Jank T, Gerhard R, Maier E, Just I, Benz R, Aktories K. Cholesterol-dependent pore formation of Clostridium difficile toxin A. J Biol Chem 2006;281;10808-10815 Abstract Jin R, Rummel A, Binz T, Brunger AT. Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity Nature 2006;444;1092-1095 Abstract Lee SH, Bigalke H. Botulinum toxin - pharmacology, safety and secondary non-response by antibodies Neuropediatrics in Clinical Department and Practice 2006;5;52-56 Overview Mahrhold S, Rummel A, Bigalke H, Davletov B, Binz T. The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves. FEBS Lett 2006;Apr3;580(8);2011-4 Abstract Molinari G, Rohde M, Wilde C, Just I, Aktories K, Chhatwal G.S. Localization of the C3-like ADP-ribosyltransferase from Staphylococcus aureus during baterial invasion of mammalian cells. Inf Immun 2006;74;3673-3677 Abstract Rosales RL, Bigalke H, Dressler D. Pharmacology of botulinum toxin: differences between type A preparations. Eur J Neurol; 2006;13;2-10 Abstract Schröder O, Gerhard R, Stein J. Antibiotic-associated diarrhea Diarrhea Z Gastroenterol 2006;44(2);193-204 Abstract Stange DE, Radlwimmer B, Schubert F, Traub F, Pich A, Toedt G, Mendrzyk F, Lehmann U, Eils R, Kreipe H, Lichter, P. High resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer. Clin Cancer Res 2006;12;345-52 Abstract Teichert M, Tatge H, Schoentaube J, Just I, Gerhard R. Application of mutated Clostridium difficile toxin A for determination of glucosyltransferase-dependent effects. Inf Immun 2006;74(10);6006-6010 Abstract Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF. Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol 2006;7(3);230-40 Abstract Traub F, Jost M, Hess R, Schorn K, Menzel C, Budde P, Schulz-Knappe P, Lamping N, Pich A, Kreipe H, Tammen H. Peptidomic analysis of breast cancer reveals a putative surrogate marker for estrogen receptor-negative carcinomas. Lab Invest 2006;86;246-253 Abstract Zürbig P, Renfrow MB, Schiffer E, Novak J, Walden M, Wittke S, Just I, Pelzig M, Neusüß C, Theodorescu D, Root KE, Ross MM, Mischak H. Biomarker discovery by CE.MS enables sequences analysis via MS/MS with platform-independent separation. Electrophoresis 2006;27(11);2111-21125 Abstract 2001 Barth H, Pfeifer G, Hofmann F, Maier E, Benz R, Aktories K. Low pH-induced formation of ion channels by Clostridium difficile toxin B in target cells. J Biol Chem. 2001 Apr 6; 276(14): 10670-6. Abstract Bigalke H, Wohlfarth K, Irmer A, Dengler R. Botulinum A toxin: Dysport improvement of biological availability. Exp Neurol. 2001 Mar;168(1):162-70. Abstract Dreikhausen U, Varga G, Hofmann F, Barth H, Aktories K, Resch K, Szamel M. Regulation by rho family GTPases of IL-1 receptor induced signaling: C3-like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL-2 gene expression. Eur J Immunol. 2001 May; 31(5): 1610-9. Abstract Gülke I, Pfeifer G, Liese J, Fritz M, Hofmann F, Aktories K, Barth H. Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile. Infect Immun. 2001 Oct;69(10):6004-11. Abstract Just I, Hofmann F, Genth H, Gerhard R. Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins. Int J Med Microbiol. 2001 Sep;291(4):243-50. Abstract Klussmann E, Tamma G, Lorenz D, Wiesner B, Maric K, Hofmann F, Aktories K, Valenti G, Rosenthal W. An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells. J Biol Chem. 2001 Jun 8; 276(23): 20451-7. Abstract Rollnik JD, Wohlfarth K, Dengler R, Bigalke H. Neutralizing botulinum toxin type a antibodies: clinical observations in patients with cervical dystonia. Neurol Clin Neurophysiol. 2001;2001(3):2-4. Abstract Schnittler HJ, Schneider SW, Raifer H, Luo F, Dieterich P, Just I, Aktories K. Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress. Pflugers Arch. 2001 Aug;442(5):675-87. Abstract Walev I, Bhakdi SC, Hofmann F, Djonder N, Valeva A, Aktories K, Bhakdi S. Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3185-90. Abstract Wilde C, Chhatwal GS, Schmalzing G, Aktories K, Just I. A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3. J Biol Chem 2001 Mar 23;276(12):9537-42 Abstract Yang SN, Yu J, Mayr GW, Hofmann F, Larsson O, Berggren PO. Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase. FASEB J. 2001 Aug;15(10):1753-63. Abstract 2000 Bigalke H. Neuromuscular junction - presynaptic terminal. Clin Neurophysiol 2000;31;115-121 Busch C, Hofmann F, Gerhard R, Aktories K. Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases. J Biol Chem. 2000 May 5;275(18):13228-34. Abstract Busch C, Schömig K, Hofmann F, Aktories K. Characterization of the catalytic domain of Clostridium novyi alpha-toxin. Infect Immun. 2000 Nov;68(11):6378-83. Abstract Dressler D, Bigalke H, Rothwell JC. The sternocleidomastoid test: an in vivo assay to investigate botulinum toxin antibody formation in humans. J Neurol. 2000 Aug;247(8):630-2. Abstract Dressler D, Dirnberger G, Bhatia KP, Irmer A, Quinn NP, Bigalke H, Marsden CD. Botulinum toxin antibody testing: comparison between the mouse protection assay and the mouse lethality assay. Mov Disord. 2000 Sep;15(5):973-6. Abstract Dressler D, Zettl U, Benecke R, Bigalke H. Can intravenous immunoglobulin improve antibody-mediated botulinum toxin therapy failure? Mov Disord. 2000 Nov;15(6):1279-81. Abstract Galmiche A, Rassow J, Doye A, Cagnol S, Chambard JC, Contamin S, de Thillot V, Just I, Ricci V, Solcia E, Van Obberghen E, Boquet P. The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J. 2000 Dec 1;19(23):6361-70. Abstract Genth H, Selzer J, Busch C, Dumbach J, Hofmann F, Aktories K, Just I. New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization. Infect Immun. 2000 Mar;68(3):1094-101. Abstract Just I, Boquet P Large clostridial cytotoxins as tools in cell biology. Curr Top Microbiol Immunol 2000;250;97-107 Review Just I, Hofmann F, Aktories K Molecular mode of action of the large clostridial cytotoxins. Curr Top Microbiol Immunol 2000;250;55-83 Review Lehnardt S, Ahnert-Hilger G, Bigalke H, Jöns T. Acid secretion of parietal cells is paralleled by a redistribution of NSF and alpha, beta-SNAPs and inhibited by tetanus toxin Histochem Cell Biol. 2000 Nov;114(5):387-91. Abstract Linseman DA, Hofmann F, Fisher SK. A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinase. J Neurochem. 2000 May;74(5):2010-20. Abstract Meyer DK, Olenik C, Hofmann F, Barth H, Leemhuis J, Brunig I, Aktories K, Nörenberg W. Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1. J Neurosci. 2000 Sep 15;20(18):6743-51. Abstract Procyk KJ, Rippo MR, Testi R, Hofmann F, Parker PJ, Baccarini M. Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C. Blood. 2000 Oct 1;96(7):2592-8. Abstract Rollnik JD, Matzke M, Wohlfarth K, Dengler R, Bigalke H. Low-dose treatment of cervical dystonia, blepharospasm and facial hemispasm with albumin-diluted botulinum toxin type A under EMG guidance. An open label study. Abstract Vetter IR, Hofmann F, Wohlgemuth S, Herrmann C, Just I. Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin. J Mol Biol. 2000 Sep 1;301(5):1091-5. Abstract Wagner AH, Köhler T, Rückschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):61-9. Abstract Wilde C, Genth H, Aktories K, Just I. Recognition of RhoA by Clostridium botulinum C3 exoenzyme. J Biol Chem. 2000 Jun 2;275(22):16478-83. Abstract 1999 Feick P, Gilhaus S, Blum R, Hofmann F, Just I, Schulz I. Inhibition of amylase secretion from differentiated AR4-2J pancreatic acinar cells by an actin cytoskeleton controlled protein tyrosine phosphatase activity. FEBS Lett. 1999 May 28;451(3):269-74. Abstract Fritz G, Just I, Kaina B. Rho GTPases are over-expressed in human tumors. Int J Cancer. 1999 May 31;81(5):682-7. Abstract Genth H, Aktories K, Just I. Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling. J Biol Chem. 1999 Oct 8;274(41):29050-6. Abstract Jöns T, Lehnardt S, Bigalke H, Heim HK, Ahnert-Hilger G. SNARE proteins and rab3A contribute to canalicular formation in parietal cells. Eur J Cell Biol. 1999 Nov;78(11):779-86. Abstract Nörenberg W, Hofmann F, Illes P, Aktories K, Meyer DK. Rundown of somatodendritic N-methyl-D-aspartate (NMDA) receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase RhoA. Br J Pharmacol. 1999 Jul;127(5):1060-3. Abstract 1998 Adermann K, Raida M, Paul Y, Abu-Raya S, Bloch-Shilderman E, Lazarovici P, Hochman J, Wellhoner H. Isolation, characterization and synthesis of a novel paradaxin isoform. FEBS Lett. 1998 Sep 18;435(2-3):173-7. Abstract Barth H, Hofmann F, Olenik C, Just I, Aktories K. The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin. Infect Immun. 1998 Apr;66(4):1364-9. Abstract Barth H, Preiss JC, Hofmann F, Aktories K. Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis. J Biol Chem. 1998 Nov 6;273(45):29506-11. Abstract Ben-Ami G, Ozeri V, Hanski E, Hofmann F, Aktories K, Hahn KM, Bokoch GM, Rosenshine I. Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli. Infect Immun. 1998 Apr;66(4):1755-8. Abstract Boquet P, Munro P, Fiorentini C, Just I. Toxins from anaerobic bacteria: speficity and molecular mechanism of action. Curr Opinion Microbiol 1998;1;66-74 Abstract Busch C, Hofmann F, Selzer J, Munro S, Jeckel D, Aktories K. A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins. J Biol Chem. 1998 Jul 31;273(31):19566-72. Abstract Gerhard R, Schmidt G, Hofmann F, Aktories K. Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells. Infect Immun. 1998 Nov;66(11):5125-31. Abstract Herrmann C, Ahmadian MR, Hofmann F, Just I. Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35. J Biol Chem. 1998 Jun 26;273(26):16134-9. Abstract Hofmann F, Busch C, Aktories K. Chimeric clostridial cytotoxins: identification of the N-terminal region involved in protein substrate recognition. Infect Immun. 1998 Mar;66(3):1076-81. Abstract Lucius C, Arner A, Steusloff A, Troschka M, Hofmann F, Aktories K, Pfitzer G. Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins. J Physiol. 1998 Jan 1;506 ( Pt 1):83-93. Abstract Naumann M, Toyka KV, Mansouri Taleghani B, Ahmadpour J, Reiners K, Bigalke H. Depletion of neutralizing antibodies resensitizes a secondary non-responder to botulinum A neurotoxin. J Neurol Neurosurg Psychiatry. 1998 Dec;65(6):924-7. Abstract Paul Y, Weiss A, Adermann K, Erdmann G, Kassebaum C, Lazarovici P, Hochman J, Wellhoner H. Translocation of acylated pardaxin into cells. FEBS Lett. 1998 Nov 27;440(1-2):131-4. Abstract Reiser CO, Lanz T, Hofmann F, Hofer G, Rupprecht HD, Goppelt-Struebe M. Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins. Biochem J. 1998 Mar 15;330 ( Pt 3):1107-14. Abstract Schmid G, Schürmann A, Huppertz C, Hofmann F, Aktories K, Joost HG. Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin. Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):385-92. Abstract Sehr P, Joseph G, Genth H, Just I, Pick E, Aktories K. Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling. Biochemistry. 1998 Apr 14;37(15):5296-304. Abstract Wohlfarth K, Goeschel H, Frevert J, Dengler R, Bigalke H. Dose standardization of botulinum toxin: Reply. Mov Disord. 1998, 13, 750-751. Abstract 1997 Goschel, H., Wohlfarth, K., Frevert, J., Dengler, R., Bigalke, H. Botulinum A toxin therapy: neutralizing and nonneutralizing antibodies - therapeutic consequences. Exp. Neurol. 147, 1997, 96-102. Abstract Hippenstiel, S., Tannert-Otto, S., Vollrath, N., Krüll, M., Just, I., Aktories, K., von Eichel-Streiber, C., Suttorp, N. Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function. Am. J. Physiol. 1997, 272, L38-L43. Abstract Hofmann, F., Busch, C., Prepens, U., Just, I., Aktories, K. Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of holotoxin. J. Biol. Chem. 1997, 272, 11074-11078. Abstract Olenik, C., Barth, H., Just, I., Aktories, K., Meyer, D.K. Gene expression of the small GTP binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult brain. Mol. Brain Res. 1997, 52, 272-279. Abstract Otto, B., Steusloff, A., Just, I., Aktories, K., Pfitzer, G. Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea pig intestinal smooth muscle. J. Physiol. (Lond.), 1997, 496, 317-329. Abstract Verschueren, H., de Baetselier, P., de Braekeleer, J., Dewitt, J., Aktories, K., Just, I. ADP-ribosylation of Rho-proteins with botulinum C3 exoenzyme inhibits invasion and shape changes of T-lymphoma cells. Eur. J. Cell Biol. 1997, 73, 182-187. Abstract Wohlfarth, K., Goschel, H., Frevert, J., Dengler, R., Bigalke, H. Botulinum A toxins: units versus units. Naunyn Schmiedeberg's Arch. Pharmacol. 1997, 355, 335-40. Abstract

from a telemedicine-based, multimodal aftercare approach. Front. Nephrol. 5:1569116. doi: 10.3389/fneph.2025.1569116 Kreuzer M, Prüfe J, Dierks M-L , Müther S, Bethe D, Büscher A, Heindl-Rusai K, Hollenbach