Publications of the Institute since 1997
Polten,Felix ; Sandu,Mircea-Andrei ; Faix,Jan ; Hegermann,Jan ; Kriedemann,Nils ; Zweigerdt,Robert ; Thum,Thomas ; Bauersachs,Johann ; Niessen,Hans W. ; Koenig,Andrew L. ; Lavine,Kory J. ; Pich,Andreas ; Wang,Yong ; Reboll,Marc R. ; Korf-Klingebiel,Mortimer ; Wollert,Kai C. ;
Extracellular BRICK1 drives heart repair after myocardial infarction in mice,
United States,Sci.Transl.Med.,2026;18(831):eadx2876
Originalpublikation
Bai,Yiling ; Wu,Zhaojia ; Leary,Scot C. ; Fang,Chen ; Yu,Michelle ; Genth,Harald ; Xie,Yufeng ; Shi,Jinhui ; Xiang,Jim ;
Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways,
Switzerland,Int.J.Mol.Sci.,2025;26(4):1669
Originalpublikation
Bellmann,Denise ;
Evaluation of the neutralizing activity of newly developed equine antibodies against C. botulinum neurotoxins using in vitro differentiated P19 neurons,
Hannover,,2025;()
Masterarbeit
Bollenbach,Alexander ; Beckmann,Bibiana ; Tsikas,Dimitrios ;
Quality control in GC-MS analysis of amino acids in human urine and plasma: Possible implications for targeted and untargeted metabolomics,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1262():124661
Originalpublikation
Bünermann,Ines ; Detering,Nora ; Tapken,Ines ; Kuhn,Daniela ; Jahn,Kirsten ; Burkert,Alexandra ; Naczinsky,Sarah ; Hensel,Niko ; Schüning,Tobias ; Dittrich-Breiholz,Oliver ; Pich,Andreas ; Claus,Peter ;
Alterations along the neuroendocrine axis of leptin homeostasis: white adipose tissue and hypothalamus in a severe SMA mouse model,
England,Hum.Mol.Genet.,2025;():-
Originalpublikation
Chung,Bomee ; Jonas,Wenke ; Rostami,Fatemeh ; Malik,Zulaikha ; Szaroszyk,Malgorzata ; Levay,Magdolna ; Thackeray,James ; Ost,Mario ; Nowak,Steven ; Hegermann,Jan ; Wieland,Thomas ; Pich,Andreas ; Bengel,Frank M. ; Bauersachs,Johann ; Wollert,Kai C. ; Heineke,Joerg ; Schürmann,Annette ; Kempf,Tibor
Iron regulatory proteins secure iron availability in skeletal muscle to preserve exercise tolerance in heart failure
England,Cardiovasc.Res.,2025;()
Originalpublikation
Chung,Soo-Young ;
Die Bedeutung konservierter Cysteine für die Funktion der Clostridium difficile Toxine A und B,
Hannover,,2024;():4 ungezählte Blätter, 45 Blätter
Dissertation
Dastagir,Nadjib ; Liebsch,Christina ; Kutz,Jaqueline ; Wronski,Sabine ; Pich,Andreas ; Obed,Doha ; Vogt,Peter Maria ; Bucan,Vesna ; Strauß,Sarah ;
Identification of antimicrobial peptides from the Ambystoma mexicanum displaying antibacterial and antitumor activity,
United States,PLoS One,2025;20(3):-e0316257
Originalpublikation
Dettmann,Paulin ; Skiba,Martin ; Stern,Daniel ; Weisemann,Jasmin ; Mages,Hans Werner ; Krez,Nadja ; Dorner,Martin B. ; Schaarschmidt,Sara ; Avondet,Marc A. ; Fulde,Marcus ; Rummel,Andreas ; Strommenger,Birgit ; Maurischat,Sven ; Dorner,Brigitte G. ;
Highly Sensitive Suspension Immunoassay for Multiplex Detection, Differentiation, and Quantification of Eight Staphylococcus aureus Enterotoxins (SEA to SEI),
Switzerland,Toxins (Basel),2025;17(6):265-http://doi.org/10.3390/toxins17060265
Originalpublikation
Dietz-Ziegler,Stefanie ; Kewitz,Samantha ; Kaiser,Gabriele ; Rühle,Jessica ; Marmé,Alexander ; Dalpke,Alexander ; Cheaib,Bachar ; Pauluschke-Fröhlich,Jan ; Henes,Melanie ; Velic,Ana ; Pich,Andreas ; Vollert,Anneli ; Schaller,Martin ; Knab,Felix ; Lajqi,Trim ; Poets,Christian F. ; Gille,Christian ; Köstlin-Gille,Natascha
Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy-Supportive Phenotype In Vitro,
Germany,Eur.J.Immunol.,2025;55(9):e70056
Originalpublikation
Frommeyer,Yannick N. ; Gomez,Nicolas O. ; Preusse,Matthias ; Arce-Rodriguez,Alejandro ; Neubauer,Kerstin ; Kennepohl,Benedikt ; Witte,Julius ; Bouheraoua,Safaa ; Cetraro,Pierina ; Erdmann,Jelena ; Neumann-Schaal,Meina ; Müsken,Mathias ; Pich,Andreas ; Bähre,Heike ; Depledge,Daniel P. ; Häussler,Susanne ;
tRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity,
England,Nucleic Acids Res.,2025;53(14):gkaf719
Originalpublikation
Gand,Luis Vincens ; Lanzuolo,Chiara ; Li,Mugeng ; Rosti,Valentina ; Weber,Natalie ; Lu,Dongchao ; Bär,Christian ; Thum,Thomas ; Pich,Andreas ; Kraft,Theresia ; Amrute-Nayak,Mamta ; Nayak,Arnab ;
Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine-Induced Cachexia,
Germany,J.Cachexia Sarcopenia Muscle,2025;16(2):-e13776
Originalpublikation
Gao,Linfeng ; Nowakowska,Maria Barbara ; Selby,Katja ; Przykopanski,Adina ; Chen,Baohua ; Krüger,Maren ; Douillard,François Paul ; Lam,Kwok-Ho ; Chen,Peng ; Huang,Ting ; Minton,Nigel Peter ; Dorner,Martin Bernhard ; Dorner,Brigitte Gertrud ; Rummel,Andreas ; Lindström,Miia ; Jin,Rongsheng ;
Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47,
United States,Nat.Struct.Mol.Biol.,2025;():-
Originalpublikation
Hage,David S. ; Liu,Huwei ; Theodoridis,Georgios ; Tsikas,Dimitrios ; Virgilliou,Christina ; Wilson,Ian ;
Chemical analysis-relating nomenclature issues in the Journal of Chromatography B,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1263():124703
Originalpublikation
Heimerl,Maren ; Erschow,Sergej ; Müller-Olling,Mirco ; Manstein,Dietmar J. ; Decher,Niels ; Kauferstein,Silke ; Jenewein,Tina ; Pich,Andreas ; Ricke-Hoch,Melanie ; Hilfiker-Kleiner,Denise ;
Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression,
England,Eur.Heart J.,2025;():
Originalpublikation
Horn,Vanessa ; Zarnovican,Patricia ; Tiemann,Birgit ; Pich,Andreas ; Bakker,Hans ; Routier,Françoise H. ;
N-Glycoproteomics of the Apicomplexan Parasite Toxoplasma gondii,
Germany,,2025;():-e202400239
Originalpublikation
Ibrahim,Nurul Khalida ; Schreek,Sabine ; Cinar,Buesra ; Stasche,Anna Sophie ; Lee,Su Hyun ; Zeug,Andre ; Dolgner,Tim ; Niessen,Julia ; Ponimaskin,Evgeni ; Shcherbata,Halyna ; Fehlhaber,Beate ; Bourquin,Jean-Pierre ; Bornhauser,Beat ; Stanulla,Martin ; Pich,Andreas ; Gutierrez,Alejandro ; Hinze,Laura ;
SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response,
United States,Cell.Rep.,2025;44(4):
Originalpublikation
Jordan,Maria ; Schmidt,Kevin ; Fuchs,Maximilian ; Just,Annette ; Pfanne,Angelika ; Willmer,Lena ; Neubert,Lavinia ; Werlein,Christopher ; Zardo,Patrick ; Pich,Andreas ; Thum,Thomas ; Fiedler,Jan ;
Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung,
Switzerland,Front.Pharmacol.,2025;16():1534989
Originalpublikation
Josuran,Roland ; Wenger,Andreas ; Worbs,Sylvia ; Kampa,Bettina ; Rummel,Andreas ; Dorner,Brigitte G. ; Gerber,Sabina ;
N-Glycosylation Profile of Abrin Certified EU Reference Material,
Switzerland,Toxins (Basel),2025;17(3):108
Originalpublikation
Kaiser,Annette ; Agostinelli,Enzo ; Tsikas,Dimitrios
The hypusine pathway in Ixodes ricinus: molecular cloning and validation of deoxyhypusine synthase as a novel target for drug discovery to treat and prevent vector borne diseases
Switzerland,Front.Cell.Infect.Microbiol.,2025;15():1638906
Originalpublikation
Kroh,Amelie ;
Charakterisierung der nichttoxischen OrfX-Proteine 1-3 sowie P47 aus Clostridium botulinum Serotyp E Subtyp E1 Stamm Beluga,
Hannover,,2024;():XII, 154 Blätter, Blatt XIII-XX : Illustrationen, Diagramme
Dissertation
Lam,Kwok-Ho ; Gao,Linfeng ; Przykopanski,Adina ; Chen,Baohua ; Huang,Ting ; Krüger,Maren ; Bartels,Anna-Magdalena ; Dorner,Martin Bernhard ; Perry,Kay ; Dorner,Brigitte Gertrud ; Rummel,Andreas ; Jin,Rongsheng ;
A nut-and-bolt assembly of the bimodular large progenitor botulinum neurotoxin complex,
United States,Sci.Adv.,2025;11(35):eadx5831
Originalpublikation
Masuyer,Geoffrey ; Rummel,Andreas ; Stenmark,Pål ;
Botulinum neurotoxin A mutants with enhanced ganglioside binding show improved potency and altered ganglioside selectivity,
England,Commun.Chem.,2025;8(1):171
Originalpublikation
Ostermann,Lena ; Seeliger,Benjamin ; Peukert,Konrad ; Steinmetz,Lara-Kristin ; Flasche,Carolin ; Maus,Regina ; Stolper,Jennifer ; Vogl,Thomas ; Pich,Andreas ; Bode,Christian ; Neumann,Konstantin ; Brand,Korbinian ; Tessier,Philippe A. ; Roth,Johannes ; Maus,Ulrich A. ;
Lack of S100A8 impairs lung protective immunity against Streptococcus pneumoniae,
United States,J.Infect.Dis.,2025;()
Originalpublikation
Paulmann,Volker ; Mikuteit,Marie ; Just,Ingo ; Karmann,Naomi ; Steffens,Sandra ;
The science module in the MHH's model curriculum - development, implementation, results,
Germany,GMS J.Med.Educ.,2025;42(5):Doc59
Originalpublikation
Ramachandran,Dhanya ; Dewender,Robin Tarek ; Schröder-Heurich,Bianca ; Froböse,Wiebke ; Avdulahu,Florian ; Richter,Katja ; Baker,Valerie L. ; Winn,Virginia D. ; Pich,Andreas ; von Versen-Höynck,Frauke
Exploring the plasma proteome linked to corpus luteum presence and conception mode across pregnancy stages and postpartum
Netherlands,J.Assist.Reprod.Genet.,2025
Originalpublikation
Schmidt,Arne ; Schmidt,Kevin ; Groß,Sonja ; Lu,Dongchao ; Xiao,Ke ; Neufeldt,Dimyana ; Cushman,Sarah ; Lehmann,Nele ; Thum,Sabrina ; Pfanne,Angelika ; Just,Annette ; Pich,Andreas ; Heinz,Alexander ; Hiller,Karsten ; Hunkler,Hannah Jill ; Tan,Wilson Lek Wen ; Foo,Roger ; Bär,Christian ; Thum,Thomas ; Jung,Mira ;
Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism,
England,Sci.Rep.,2025;15(1):20331
Originalpublikation
Smandzich,Nadine J. ; Pich,Andreas ; Gschwendtberger,Thomas ; Greten,Stephan ; Ye,Lan ; Klietz,Martin ; Di Fonzo,Alessio ; Henkel,Lisa M. ; Wegner,Florian
Proteomics of Patient-Derived Striatal Medium Spiny Neurons in Multiple System Atrophy
Switzerland,,2025;14(17):1394
Originalpublikation
Steinberg,Maximilian ; Wilk,Laura-Varenne ; Stern,Daniel ; Weisemann,Jasmin ; Messelhäußer,Ute ; Wittwer,Matthias ; Krüger,Maren ; Mages,Hans Werner ; Rummel,Andreas ; Dorner,Martin B. ; Dorner,Brigitte G. ;
Validation of an Endopep-suspension immunoassay for the diagnostics of human botulism,
Germany,ALTEX,2025;():
Originalpublikation
Tammen,Harald ; Pich,Andreas ; Hess,Rüdiger ; Lechowicz,Urszula ; Janciauskiene,Sabina ; Chorostowska,Joanna ;
Quantitative mass spectrometric analysis of C-terminal 36 amino acid peptides of alpha-1 antitrypsin in plasma using survey spectra,
United States,Methods,2025;240():7-13
Originalpublikation
Tsikas,Dimitrios ;
Analysis of eicosanoids by quadrupole gas chromatography-negative ion chemical ionization-tandem mass spectrometry as pentafluorobenzyl trimethylsilyl derivatives: Naming the Murphy rearrangement
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1267():124794
Übersicht
Tsikas,Dimitrios ;
Analysis, biology and significance of dimethylamine, trimethylamine and trimethylamine N-oxide in humans and in the marine ecosystem,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1258():124602
Originalpublikation
Tsikas,Dimitrios ;
Assessment of matrix effects in quantitative GC-MS by using isotopologs,
United States,Anal.Biochem.,2025;705():115928
Originalpublikation
Tsikas,Dimitrios ;
Interpretation of negative-ion chemical ionization GC-MS and GC-MS/MS mass spectra of perfluorinated organic analyte derivatives: Consideration of reduction reactions in the gas phase,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1253():124487
Originalpublikation
Tsikas,Dimitrios ;
Pentafluorobenzyl bromide - A versatile derivatization agent in chromatography and mass spectrometry: II. Analysis of organic acids and bases, and comparison with other perfluorinated reagents,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1257():124578
Originalpublikation
Tsikas,Dimitrios ;
Proposal and application of nitrogen rules in interpreting gas chromatography negative-ion chemical ionization mass spectrometry spectra,
United States,Anal.Biochem.,2025;705():115922
Originalpublikation
Tsikas,Dimitrios ;
Quantitative GC-MS/MS in the clinical analysis of eicosanoids: A critical review and discussion, a 40-years historical retrospect, and possible implications for LC-MS/MS,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1270():124911
Originalpublikation
Tsikas,Dimitrios ;
Quantitative GC-NICI-MS and GC-NICI-MS/MS analysis by using isotopologs as internal standards: A tutorial review,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1262():124648
Originalpublikation
Tsikas,Dimitrios ;
Underlying Mechanisms of Chromatographic H/D, H/F, cis/trans and Isomerism Effects in GC-MS,
Switzerland,,2025;15(1):43-
Originalpublikation
Tsikas,Dimitrios S. ; Tsikas,Stefanos A. ;
Collision-Induced Gas-Phase Reactions of PFB-TMS Derivatives of F(2)-Prostaglandins in Quadrupole GC-NICI-MS/MS: A Mini-Review and a Meta-Analysis,
Switzerland,Molecules,2025;30(19):3846-
Originalpublikation
Ückert,Stefan ; Hedlund,Petter ; Tsikas,Dimitrios ; Kuczyk,Markus A. ;
The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract,
Germany,World J.Urol.,2025;44(1):26
Originalpublikation
Wolter,Sabine ; Neumann,Martin ; Koenig,Theresa ; Hagedorn,Tina ; Schwede,Frank ; Pich,Andreas ; Seifert,Roland
Identification of cCMP- and cUMP-binding proteins using cCMP and cUMP coupled to agarose and biotin matrices,
United States,PLoS One,2025;20(10):e0333904-
Originalpublikation
Abbas,Naisam ; Bentele,Marco ; Waleczek,Florian J. G. ; Fuchs,Maximilian ; Just,Annette ; Pfanne,Angelika ; Pich,Andreas; Linke,Sophie ; Neumüller,Susanne ; Stucki-Koch,Angelika ; Jordan,Maria ; Perbellini,Filippo ; Werlein,Christopher ; Korte,Wilhelm ; Ius,Fabio ; Ruhparwar,Arjang ; Weber,Natalie ; Fiedler,Jan ; Thum,Thomas ;
Ex vivo modeling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine
J.Mol.Cell.Cardiol, 2024, 196(), 125- 140,
Original publication
Abbas,Naisam ; Haas,Jonas A. ; Xiao,Ke ; Fuchs,Maximilian ; Just,Annette ; Pich,Andreas; Perbellini,Filippo ; Werlein,Christopher ; Ius,Fabio ; Ruhparwar,Arjang ; Fiedler,Jan ; Weber,Natalie ; Thum,Thomas ;
Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo
Eur.Heart J., 2024, 45(22), 2016- 2018,
Original publication
Albers,Marco Darius ; Tiemann,Birgit ; Kaynert,Jonas Till ; Pich,Andreas; Bakker, Hans ;
Conserved cysteines prevent C-mannosylation of mucin Cys domains,
England, FEBS J., 2024; 291(15):3539-3552
Original publication
Baskal,Svetlana; Posma, Rene A. ; Bollenbach, Alexander; Dieperink, Willem ; Bakker, Stephan J. L. ; Nijsten, Maarten W. ; Touw, Daan J. ; Tsikas, Dimitrios;
GC-MS analysis of 4-hydroxyproline: increased proline hydroxylation in patients with metformin-associated lactic acidosis and metformin-treated patients with Becker muscular dystrophy,
Austria, Amino Acids, 2024; 56(1):21-
Original publication
Dimina,Laurianne Jolata ; Leray,Vincent ; Voute,Marion ; David,Jérémie ; Blavignac,Christelle ; Farges,Marie-Chantal ; Rossary,Adrien ; Tsikas,Dimitrios; Rémond,Didier ; Pickering,Gisèle ; Mariotti,François ;
Dietary Protein in a Challenge Meal Does Not Alleviate Postprandial Impairments in Vascular Endothelial Function in Healthy Older Adults with Cardiometabolic Risk: A Randomized Crossover-Controlled Trial
J.Nutr, 2024, 154(12), 3664- 3680,
Original publication
Hedlund,Petter ; Rahardjo,Harrina E. ; Tsikas,Dimitrios; Kuczyk,Markus A. ; Ückert,Stefan ;
Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion therapy (MET)
World J.Urol., 2024, 42(1), 654- ,
Original publication
Hirsch,Merle S. ; Hildebrand, Christina B. ; Geltinger,Florian ; Pich,Andreas; Mühlfeld,Christian ; Wedekind, Dirk ; Brandenberger, Christina ; Senescence in alveolar epithelial type II cells promotes acute lung injury and impairs regeneration,United States,Am.J.Respir.Cell Mol.Biol.,2024; ():-
Original publication
Hose, Leonie; Langenhagen, Alina Katharina; Kefalakes, Ekaterini; Schweitzer, Theresa; Kubinski, Sabrina; Barak, Segev; Pich, Andreas; Grothe, Claudia
A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice.
PMID: 38185886
Original publication
Khan,Bushra ; Lanzuolo,Chiara ; Rosti,Valentina ; Santarelli,Philina ; Pich,Andreas; Kraft,Theresia ; Amrute-Nayak,Mamta ; Nayak,Arnab ;
Sorafenib induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes,
United States,,2024;27(10):110913
Original publication
Klawitter,Jost ; Weissenborn,Wiebke ; Gvon,Iuliia ; Walz,Mackenzie ; Klawitter,Jelena ; Jackson,Matthew ; Sempio,Cristina ; Joksimovic,Sonja L. ; Shokati,Touraj ; Just,Ingo; Christians,Uwe ; Todorovic,Slobodan M. ;
β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia?
Mol. Pharmacol., 2024, 105(2), 75- 83,
Original publication
Krueger,Jonas ; Preusse,Matthias ; Oswaldo Gomez,Nicolas ; Frommeyer,Yannick Noah ; Doberenz,Sebastian ; Lorenz,Anne ; Kordes,Adrian ; Grobe,Svenja ; Müsken,Mathias; Depledge,Daniel P. ; Svensson,Sarah L. ; Weiss,Siegfried ; Kaever,Volkhard ; Pich,Andreas ; Sharma,Cynthia M. ; Ignatova,Zoya ; Häussler,Susanne ;
tRNA epitranscriptome determines pathogenicity of the opportunistic pathogen Pseudomonas aeruginosa,
United States,Proc.Natl.Acad.Sci.U.S.A.,2024;121(11):-e2312874121
Originalpublikation
Kukoc-Modun, Lea; Kraljevic, Tomislav; Tsikas, Dimitrios; Spassov, Tony G; Kolev, Spas D
Determination of -Acetyl-L-cysteine Ethyl Ester (NACET) by Sequential Injection Analysis.
PMID: 38257405
Original publication
Neufeldt,Dimyana ; Schmidt,Arne ; Mohr,Elisa ; Lu,Dongchao; Chatterjee,Shambhabi ; Fuchs,Maximilian; Xiao,Ke ; Pan,Wen; Cushman,Sarah; Jahn,Christopher; Juchem,Malte; Hunkler,Hannah Jill ; Cipriano,Giuseppe ; Jürgens,Bjarne ; Schmidt,Kevin ; Groß,Sonja ; Jung,Mira ; Hoepfner,Jeannine ; Weber,Natalie ; Foo,Roger ; Pich,Andreas; Zweigerdt,Robert ; Kraft,Theresia ; Thum,Thomas ; Bär,Christian ;
Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival,
Germany,Basic Res.Cardiol.,2024;119(4):613-632
Original publication
Oms,Elisabeth;
Investigation of the RGD motif in the binding and uptake of C3bot in HT22 cells,
Hannover,,2024;():-4 uncounted sheets, 98 sheets :
Dissertation
Posma,Rene A. ; Bakker,Stephan J. L. ; Nijsten,Maarten W. ; Touw,Daan J. ; Tsikas,Dimitrios;
Comprehensive GC-MS Measurement of Amino Acids, Metabolites, and Malondialdehyde in Metformin-Associated Lactic Acidosis at Admission and during Renal Replacement Treatment,
Switzerland,J.Clin.Med.,2024;13(13):3692-
Original publication
Post,Adrian ; Groothof,Dion ; Kremer,Daan ; Knobbe,Tim J. ; Abma,Willem ; Koops,Christa A. ; Tsikas,Dimitrios; Wallimann,Theo ; Dullaart,Robin P. F. ; Franssen,Casper F. M. ; Kema,Ido P. ; Heiner-Fokkema,M. Rebecca ; Bakker,Stephan J. L. ;
Creatine homeostasis and the kidney: comparison between kidney transplant recipients and healthy controls,
Austria,Amino Acids,2024;56(1):42-
Original publication
Przykopanski,Adina;
Investigation of the complex formation of the proteinogenic botulinum neurotoxin with its associated proteins and their influence on the transepithelial transport of the toxin
2023,
Dissertation
Sainz von Petzinger,Sylvana;
Protective effects of chitosan oligosaccharides against Clostridioides difficile toxin A and toxin B
2024,
Master thesis
Schmidt,Kevin ; Schmidt,Arne ; Groß,Sonja ; Just,Annette ; Pfanne,Angelika ; Fuchs,Maximilian ; Jordan,Maria ; Mohr,Elisa ; Pich,Andreas; Fiedler,Jan ; Thum,Thomas ;
SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation,
England,Sci.Rep.,2024;14(1):16459-
Original publication
Scholz,Jonas ; Stephan,Till ; Pérez,Aina Gallemí ; Csiszár,Agnes ; Hersch,Nils ; Fischer,Lisa S. ; Brühmann,Stefan ; Körber,Sarah ; Litschko,Christof ; Mijanovic,Lucija ; Kaufmann,Thomas ; Lange,Felix ; Springer,Ronald ; Pich,Andreas; Jakobs,Stefan ; Peckham,Michelle ; Tarantola,Marco ; Grashoff,Carsten ; Merkel,Rudolf ; Faix,Jan ;
Decisive role of mDia-family formins in cell cortex function of highly adherent cells
Sci.Adv., 2024, 10(44), - eadp5929,
Original publication
Tapken,Ines ; Schweitzer,Theresa ; Paganin,Martina ; Schüning,Tobias ; Detering,Nora T. ; Sharma,Gaurav ; Niesert,Moritz ; Saffari,Afshin ; Kuhn,Daniela ; Glynn,Amy ; Cieri,Federica ; Santonicola,Pamela ; Cannet,Claire ; Gerstner,Florian ; Faller,Kiterie M. E. ; Huang,Yu-Ting ; Kothary,Rashmi ; Gillingwater,Thomas H. ; Di Schiavi,Elia ; Simon,Christian M. ; Hensel,Niko ; Ziegler,Andreas ; Viero,Gabriella ; Pich,Andreas; Claus,Peter ;
The systemic complexity of a monogenic disease: the molecular network of spinal muscular atrophy
Brain, 2024, (), - ,
Original publication
Tsap,Mariana I. ; Yatsenko,Andriy S. ; Hegermann,Jan ; Beckmann,Bibiana; Tsikas,Dimitros ; Shcherbata,Halyna R. ;
Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier,
England,Elife,2024;13():-e98020
Original publication
Tsikas, Dimitrios
Application of the Bland-Altman and Receiver Operating Characteristic (ROC) Approaches to Study Isotope Effects in Gas Chromatography-Mass Spectrometry Analysis of Human Plasma, Serum and Urine Samples
Molecules, 29(2):365, 2024 ISSN:1420-3049 (electronic)PMID:38257277 "DOI:10.3390/molecules29020365 "
Original publication
Tsikas,Dimitrios;
Perspectives of quantitative GC-MS, LC-MS and ICP-MS in clinical medicine - The role of analytical chemistry,
Switzerland, J.Clin.Med., 2024; 13(23):7276
Original publication
Tsikas,Dimitrios;
Underlying mechanisms of chromatographic H/D, H/F, cis/trans and isomerization effects in GC-MS,
Switzerland, 2025; 15(1):43
Original publication
Waleczek,Florian J. G. ; Cipriano,Giuseppe ; Haas,Jonas A. ; Garg,Ankita ; Pfanne,Angelika ; Just,Annette ; Neumüller,Susanne ; Hegermann,Jan ; Pich,Andreas; Radocaj,Ante ; Xiao,Ke ; Weber,Natalie ; Thum,Thomas ;
Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure
Int.J.Mol.Sci, 2024, 26(1), 218- ,
Original publication
Wu,Xuekun ; Zheng,Linqun ; Reboll,Marc R. ; Hyde,Lillian F. ; Mass,Elvira ; Niessen,Hans W. ; Kosanke,Maike ; Pich,Andreas; Giannitsis,Evangelos ; Tillmanns,Jochen ; Bauersachs,Johann ; Heineke,Joerg ; Wang,Yong ; Korf-Klingebiel,Mortimer ; Polten,Felix; Wollert,Kai C. ;
Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair,
England,Nat.Cardiovasc.Res.,2024;3(2):186-202
Original publication
Zobl,Walter;
Integration of in vitro methods into regulatory hazard assessment: two proof-of-concept case studies,
Hannover,,2024;():IX, 20, 17 sheets, sheet 38, 14 sheets-77 : Illustrations, diagrams
Dissertation
Bousnaki,Maria; Bakopoulou,Athina; Grivas,Ioannis; Bekiari,Chrysa; Pich,Andreas; Rizk,Marta; Keklikoglou,Kleoniki; Papachristou,Eleni; Papadopoulos,Georgios C.; Kritis,Aristeidis; Mikos,Antonios G.; Koidis,Petros;
Treatment of TMJ osteoarthritis by dental stem cell secretome,
United States,StemCell.Rev.Rep.,2023; 19(8):2957-2979
Original publication
Deppe,Julian;
Investigation of the function of the HCN domain of clostridial neurotoxins,
Hannover,,2022; ():V, 15, 22 sheets, pages VI-XXII : illustrations, diagrams
Dissertation
Eggenkemper,Lisa; Schlegtendal,Anne; Maier,Christoph; Lücke,Thomas; Brinkmann,Folke; Beckmann,Bibiana; Tsikas,Dimitrios; Koerner-Rettberg,Cordula;
Impaired nitric oxide synthetase activity in primary ciliary dyskinesia-data-driven hypothesis,
Switzerland,J.Clin.Med.,2023; 12(18):6010
Original publication
Emons,Barbara; Arning,Larissa; Makulla,Vera-Estelle; Suchy,Maria-Theresia; Tsikas,Dimitrios; Lücke,Thomas; Epplen,Jörg T.; Juckel,Georg; Roser,Patrik;
Endocannabinergic modulation of central serotonergic activity in healthy human volunteers,
England,Ann.Gen.Psychiatry.,2023; 22(1):11
Original publication
Gao,Linfeng; Lam,Kwok-Ho; Liu,Shun; Przykopanski,Adina; Lübke,Johanna; Qi,Ruifeng; Krüger,Maren; Nowakowska,Maria B.; Selby,Katja; Douillard,François P.; Dorner,Martin B.; Perry,Kay; Lindström,Miia; Dorner,Brigitte G.; Rummel,Andreas; Jin,Rongsheng;
Crystal structures of OrfX1, OrfX2 and the OrfX1-OrfX3 complex from the orfX gene cluster of botulinum neurotoxin E1,
England, FEBS Lett.,2023597(4):524-537 10.1002/1873-3468.14576,
Original publication
Haukamp,Funmilola Josephine; Hartmann,Zoe Maria; Pich,Andreas; Kuhn,Joachim; Blasczyk,Rainer; Stieglitz,Florian; Bade-Döding,Christina;
HLA-B*57:01/Carbamazepine-10,11-epoxide association triggers upregulation of NFkappaB and JAK/STAT signaling pathways,
Switzerland,Cells,2023;12(5):676-10.3390 /cells12050676 Reporting year:2023 | ID: RefID:26161-haukamp2023hla-b*57:01/carbamazepine-1
Original publication
Heils,Lucas; Schneemann,Martina; Gerhard,Ralf; Schulzke,Jörg-Dieter; Bücker,Roland;
CDT of Clostridioides difficile induces MLC-dependent intestinal barrier dysfunction in HT-29/B6 epithelial cell monolayers,
Switzerland,Toxins (Basel),2023;15(1):54-10.3390 /toxins15010054, reporting year:2023 | ID: RefID:26111-heils2023cdt
Original publication
Hildebrand,Christina B.; Lichatz,Rita; Pich,Andreas; Mühlfeld,Christian; Woltemate,Sabrina; Vital,Marius; Brandenberger,Christina;
Short-chain fatty acids ameliorate aging and acute lung injury in old mice,
United States,Am.J.Physiol.Lung Cell.Mol.Physiol.,2023;():- 10.1152/ajplung.00296.2022 Reporting year:2023 | ID: RefID:26113-hildebrand2023short
Original publication
Hollwedel, Femke D; Maus, Regina; Stolper, Jennifer; Iwai, Satoru; Kasai, Hayato; Holtfreter, Silva; Pich, Andreas; Neubert, Lavinia; Welte, Tobias; Yamasaki, Sho; Maus, Ulrich A
Ectopic expression of C-type lectin Mincle renders mice susceptible to staphylococcal pneumonia.
PMID: 38159068
Original publication
Joensuu,Merja; Syed,Parnayan; Saber,Saber H.; Lanoue,Vanessa; Wallis,Tristan P.; Rae,James; Blum,Ailisa; Gormal,Rachel S.; Small,Christopher; Sanders,Shanley; Jiang,Anmin; Mahrhold,Stefan; Krez,Nadja; Cousin,Michael A.; Cooper-White,Ruby; Cooper-White,Justin J.; Collins,Brett M.; Parton,Robert G.; Balistreri,Giuseppe; Rummel,Andreas; Meunier,Frederic A.;
Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry,
England,EMBO J.,2023;42(13):-e112095 10.15252/embj.2022112095 Reporting year:2023 | ID: RefID:39384-joensuu2023presynaptic
Original publication
Liu,Zheng; Lee,Pyung-Gang; Krez,Nadja; Lam,Kwok-Ho; Liu,Hao; Przykopanski,Adina; Chen,Peng; Yao,Guorui; Zhang,Sicai; Tremblay,Jacqueline M.; Perry,Kay; Shoemaker,Charles B.; Rummel,Andreas; Dong,Min; Jin,Rongsheng; Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2,
England,Nat.Commun.,2023;14(1):2338-10.1038/s41467-023-37860-8 Reporting year:2023 | ID: RefID:26323-liu2023structural
Original publication
Manion,John; Musser,Melissa A.; Kuziel,Gavin A.; Liu,Min; Schäfer,Amy; Wang,Siyu; Lee,Pyung-Gang; Zhao,Leo; Zhang,Jie; Marreddy,Ravi K. R.; Goldschmied,Jeffrey D.; Yuan,Ke; Hürde,Julian G. Gerhard,Ralf; Jin,Rongsheng; Rakoff-Nahoum,Seth; Rao,Meenakshi; Dong,Min;
C. difficile poisons neurons and pericytes to drive neurogenic inflammation,
England,,2023; 622(7983):611-618
Original publication
Baxolele Mhlekude, Dylan Postmus, Saskia Stenzel, January Weiner 3rd, Jenny Jansen, Francisco J Zapatero-Belinchón, Ruth Olmer, Anja Richter, Julian Heinze, Nicolas Heinemann, Barbara Mühlemann, Simon Schroeder, Terry C Jones, Marcel A Müller, Christian Drosten, Andreas Pich, Volker Thiel, Ulrich Martin, Daniela Niemeyer, Gisa Gerold, Dieter Beule, Christine Goffinet
Pharmacologic inhibition of bromodomains and extraterminal proteins induces an NRF-2-mediated antiviral state that is subverted by SARS-CoV-2 infection,
United States, PLoS Pathog., 2023; ():-
Original publication
Mikuteit,Marie; Baskal,Svetlana; Klawitter,Sandra; Dopfer-Jablonka,Alexandra; Behrens,Georg M. N.; Müller,Frank; Schröder,Dominik; Klawonn,Frank; Steffens,Sandra; Tsikas,Dimitrios;
Amino acids, posttranslational modifications, nitric oxide and oxidative stress in serum and urine of Long-COVID and Ex-COVID subjects,
Austria,Amino Acids,2023; 55(9):1173-1188
Original publication
Pankoke,Sophia; Schweitzer,Theresa; Biker,Rolf; Pich,Andreas; Pfarrer,Christiane; Mühlfeld,Christian; Schipke,Julia;
Obesity affects lung hypoxia adaptation,
United States,Am.J.Physiol.Lung Cell.Mol.Physiol.,2023; 325(3):L352-L359
Original publication
Pokrant,Thomas; Hein,Jens Ingo; Körber,Sarah; Disanza,Andrea; Pich,Andreas; Scita,Giorgio; Rottner,Klemens; Faix,Jan;
Ena/VASP clustering at microspike tips involves lamellipodin but not I-BAR proteins and absolutely requires unconventional myosin-X,
United States,Proc.Natl.Acad.Sci.U.S.A.,2023;120(2):-e2217437120 10.1073/pnas.2217437120 Reporting year:2023 | ID: RefID:26134-pokrant2023ena/vasp
Original publication
Rahardjo,Harrina E.; Märker,Viktoria; Tsikas,Dimitrios; Kuczyk,Markus A.; Ückert,Stefan; Bannowsky,Andreas;
Fibrotic diseases of the human urinary and genital tract: current understanding and potential treatment strategies,
Switzerland,J.Clin.Med.,2023; 12(14):4770
Original publication
Rahardjo,Harrina E. ; Ückert,Stefan ; Tsikas,Dimitrios; Bannowsky,Andreas ; Kuczyk,Markus A. ; Becker,Armin J. ;
Courses of Arginine-Vasopressin in the Systemic and Cavernous Blood through Different Stages of Sexual Arousal in Healthy Males and Patients with Erectile Dysfunction,,,2023;2023():7978734-
Original publication
Rohrbeck,Astrid; Bruhn,Vanessa Anna; Hussein,Nali; Hagemann,Sandra; Just,Ingo;
Clostridium botulinum C3bot-mediated effects on cytokine-induced psoriasis-like phenotype in full-thickness skin model,
Germany,Naunyn Schmiedebergs Arch.Pharmacol.,2023; ():-
Original publication
Rosenstein,Christopher;
Identification of a second receptor binding pocket in botulinum neurotoxin F,
Hannover,,2022;():-2 uncounted sheets, 77 sheets : 10.26068/mhhrpm/20230601-002 Reporting year:2023 | ID: RefID:26365-rosenstein2022identification
Dissertation
Schneemann,Martina; Heils,Lucas; Moos,Verena; Weiß,Franziska; Krug,Susanne M.; Weiner,January; Beule,Dieter; Gerhard,Ralf; Schulzke,Jörg-Dieter; Bücker,Roland;
A colonic organoid model exposed to the major toxins of Clostridioides difficile TcdA and TcdB exhibits deregulated tight junction proteins,
Switzerland,Toxins (Basel),2023; 15(11):643
Original publication
Schweitzer,Theresa;
Investigations on the effects of clostridial glucosylating toxins,Hannover,,2023; ():-VIII, 115 pages : illustrations, diagrams
Dissertation
Sinningen,Kathrin; Emons,Barbara; Böhme,Pierre; Juckel,Georg; Hanusch,Beatrice; Beckmann,Bibiana; Tsikas,Dimitrios; Lücke,Thomas;
L-arginine/nitric oxide signaling pathway and oxidative stress in adults with ADHD: effects of methylphenidate treatment,
United States, Nitric Oxide, 2023; 138-139():64-69
Original publication
Tsikas,Dimitrios;
Acetazolamide and human carbonic anhydrases: Review, review and discussion of an intimate relationship,
England,J.Enzyme Inhib.Med.Chem.,2024; 39(1):2291336
other
Tsikas,Dimitrios; Beckmann,Bibiana; Baskal,Svetlana; Brunner,Görig;
Pentafluoropropionic acid anhydride derivatization and GC-MS analysis of histamine, agmatine, putrescine and spermidine: effects of solvents and starting column temperature,
Switzerland,Molecules,2023; 28(3):939
Original publication
Tsikas,Dimitrios; Beckmann,Bibiana;
Quality control in targeted GC-MS for amino acid OMICS,
Switzerland,,2023; 13(9):986
Original publication
Tsikas,Dimitrios; Büttner,Petra;
Do circulating concentrations of L-arginine metabolites predict coronary artery disease status and the likelihood of cardiovascular events?,
Poland,Pol.Arch.Intern.Med.,2023;133(2):16429-10.20452 /pamw.16429 reporting:2023 | ID: RefID:26154-tsikas2023circulating
Editorial
Tsikas,Dimitrios;
GC-MS and GC-MS/MS measurement of malondialdehyde (MDA) in clinical studies: preanalytical and clinical considerations,
Netherlands,J.Mass.Spectrom.Adv.Clin.Lab.,2023; 30():10-24
Overview
Tsikas,Dimitrios;
GC-MS studies on nitric oxide autoxidation and S-nitrosothiol hydrolysis to nitrite in pH-neutral aqueous buffers: Definitive results using (15)N and (18)O isotopes,
Switzerland,Molecules,2023; 28(11):4281-http://doi.org/10.3390/molecules28114281
original-publication
Tsikas,Dimitrios;
Malondialdehyde-induced posttranslational modification of human hemoglobin,
United States,J.Proteome Res.,2023; 22(6):2141-2143
commentary
Tsikas,Dimitrios;
Mass spectrometry-based evaluation of the Bland-Altman approach: Review, discussion and proposal,
Switzerland,Molecules,2023; 28(13):4905
review
Tsikas,Dimitrios;
Measurement of nitro-oleic acid and nitro-linoleic acid in plasma by GC-MS/MS and LC-MS/MS in health and disease: The significance of the internal standard,
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2023;1221():123684-10.1016/j.jchromb.2023.123684 Reporting year:2023 | ID: RefID:26250-tsikas2023measurement
Letter
Tsikas,Dimitrios; Tsikas,Stefanos A.; Mikuteit,Marie; Ückert,Stefan;
Circulating and urinary concentrations of malondialdehyde in aging people in health and disease: review and discussion,
Switzerland,,2023; 11(10):2744
Overview
Weißenborn,Wiebke;
Pharmacological investigations of the sesquiterpene BCP as a potential postoperative opioid alternative,
Hannover,,2022; ():-4 uncounted sheets, 78 sheets
Dissertation
Baskal,S.; Beckmann,B.; Stahmer,L.; Peter,C.; Bohnhorst,B.; Das,A. M.; Tsikas,D.;
Possible role of SIRT1 and SIRT3 in post-translational modifications in human breast milk during the neonatal period,
Austria,Amino Acids,2022;():- 10.1007/s00726-022-03197-7 Reporting year:2022 | ID: RefID:25095-baskal2022role
Original publication
Baskal,S.; Bollenbach,A.; Henzi,B.; Hafner,P.; Fischer,D.; Tsikas,D.;
Stable-Isotope Dilution GC-MS Measurement of Metformin in Human Serum and Urine after Derivatization with Pentafluoropropionic Anhydride and Its Application in Becker Muscular Dystrophy Patients Administered with Metformin, l-Citrulline, or Their Combination,
Switzerland,Molecules,2022;27(12):3850-10.3390/molecules27123850 Reporting year:2022 | ID: RefID:25096-baskal2022stable-isotope
Original publication
Baskal,S.; Dimina,L.; Tsikas,S. A.; Mosoni,L.; Remond,D.; Mariotti,F. ; Tsikas,D.;
Lysine and homoarginine are closely interrelated metabolites in the rat,
Austria,Amino Acids,2022;54(6):967-976, 10.1007/s00726-022-03158-0 Reporting year:2022 | ID: RefID:25097-baskal2022lysine
Original publication
Baskal,S.; Kaiser,A.; Mels,C.; Kruger,R.; Tsikas,D.;
Specific and sensitive GC-MS analysis of hypusine, N(epsilon)-(4-amino-2-hydroxybutyl)lysine, a biomarker of hypusinated eukaryotic initiation factor eIF5A, and its application to the bi-ethnic ASOS study
Austria, Amino Acids, 2022, (), - , Reporting year: 2022| ID: 11345 (35243537)
Original publication
Baskal,S.; Tsikas,S. A.; Begou,O.; Bollenbach,A.; Lenzen,S.; Jörns,A.; Tsikas,D.;
Advanced Glycation End-Products (AGEs) of Lysine and Effects of Anti-TCR/Anti-TNF-alpha Antibody-Based Therapy in the LEW.1AR1-iddm Rat, an Animal Model of Human Type 1 Diabetes
Switzerland, Int.J.Mol.Sci., 2022, 23(3), 1541- , Reporting year: 2022| ID: 11166 (35163462)
Original publication
Baskal,Svetlana; Tsikas,Dimitrios;
Free L-Lysine and Its Methyl Ester React with Glyoxal and Methylglyoxal in Phosphate Buffer (100 mM, pH 7.4) to Form Nepsilon-Carboxymethyl-Lysine, Nepsilon-Carboxyethyl-Lysine and Nepsilon-Hydroxymethyl-Lysine.
Int J Mol Sci,2022;23(7):3446-10.3390/ijms23073446 Reporting year:2022 | ID: RefID:25100-baskal2022free
Original publication
Becker,E. ; Francino,A. ; Pich,A. ; Perrot,A. ; Kraft,T. ; Radocaj,A. ; ,
AQUA Mutant Protein Quantification of Endomyocardial Biopsy-Sized Samples From a Patient With Hypertrophic Cardiomyopathy
Switzerland, Front.Cardiovasc.Med., 2022, 9(), 816330- ,Reporting year: 2022| ID: 11362 (35265683)
Original publication
Bense,S. ; Witte,J. ; Preuße,M. ; Koska,M. ; Pezoldt,L. ; Dröge,A. ; Hartmann,O. ; Müsken,M. ; Schulze,J. ; Fiebig,T. ; Bähre,H. ; Felgner,S. ; Pich,A. ; Häussler,S. ;
Pseudomonas aeruginosa post-translational responses to elevated c-di-GMP levels,
England,Mol.Microbiol.,2022;117(5):1213-1226, 10.1111/mmi.14902 Reporting year:2022 | ID: RefID:25178-bense2022pseudomonas
Original publication
Bollenbach,A.; Baskal,S.; Mels,C. ; Kruger,R. ; Tsikas,D.;
Unusual Derivatization of Methylmalonic Acid with Pentafluorobenzyl Bromide to a Tripentafluorobenzyl Derivative and Its Stable-Isotope Dilution GC-MS Measurement in Human Urine,
Switzerland,Molecules,2022;27(16):5202-10.3390/molecules27165202 Reporting year:2022 | ID: RefID:25229-bollenbach2022unusual
Original publication
Borgert,Sebastian Roman ; Henke,Steffi ; Witzgall,Florian ; Schmelz,Stefan ; Zur Lage,Susanne ; Hotop,Sven-Kevin ; Stephen,Steffi ; Lübken,Dennis ; Krüger,Jonas ; Gomez,Nicolas Oswaldo ; van Ham,Marco ; Jänsch,Lothar ; Kalesse,Markus ; Pich,Andreas; Brönstrup,Mark ; Häussler,Susanne ; Blankenfeldt,Wulf ;
Moonlighting chaperone activity of the enzyme PqsE contributes to RhlR-controlled virulence of Pseudomonas aeruginosa,
England,Nat.Commun.,2022;13(1):7402-10.1038/s41467-022-35030-w, reporting year:2022 | ID: RefID:25237-borgert2022moonlighting
Original publication
Durisin,M. ; Krüger,C. ; Pich,A.; Warnecke,A. ; Steffens,M. ; Zeilinger,C. ; Lenarz,T. ; Prenzler,N. ; Schmitt,H. ;
Proteomic profile of patients with excellent and poor speech intelligibility after cochlear implantation: Can perilymph proteins predict performance?
United States,PLoS One,2022;17(3):-e0263765, 10.1371/journal.pone.0263765 Reporting year:2022 | ID: RefID:25549-durisin2022proteome
Original publication
Fan,C. ; Wu,Z. ; Cooper,D. M. L. ; Magnus,A. ; Harrison,K. ; Eames, B. F. ; Chibbar,R. ; Groot,G. ; Huang,J. ; Genth,H.; Zhang,J. ; Tan,X. ; Deng,Y. ; Xiang,J. ;
Activation of focal adhesion kinase restores simulated microgravity-induced inhibition of osteoblast differentiation via the Wnt/beta-catenin signaling pathway,
Switzerland,Int.J.Mol.Sci.,2022;23(10):5593-10.3390, /ijms23105593 reporting year:2022 | ID: RefID:25625-fan2022activation
Original publication
Gall,E. ; Stieglitz,F.; Pich,A. ; Behrens,G. M. N. ; Kuhn,J. ; Blasczyk,R. ; Haukamp,F. J. ; Bade-Döding,C. ;
Proteomic Profiling and T Cell Receptor Usage of Abacavir Susceptible Subjects,
Switzerland,,2022;10(3):693-10.3390, /biomedicines10030693 reporting year:2022 | ID: RefID:25735-gall2022proteomic
Original publication
Hanusch,B. ; Sinningen,K. ; Brinkmann,F. ; Dillenhöfer,S. ; Frank,M. ; Jöckel,K. H. ; Koerner-Rettberg,C. ; Holtmann,M. ; Legenbauer,T. ; Langrock,C. ; Reinehr,T. ; Maasjosthusmann,P. ; Beckmann,B.; Hamelmann,E. ; Tsikas,D.; Lücke,T. ;
Characterization of the L-arginine/nitric oxide pathway and oxidative stress in pediatric patients with atopic diseases,
Switzerland,Int.J.Mol.Sci.,2022;23(4):2136-10.3390, /ijms23042136 Reporting year:2022 | ID: RefID:25936-hanusch2022Characterization
Original publication
Harre,Jennifer ; Heinkele,Laura ; Steffens,Melanie ; Warnecke,Athanasia ; Lenarz,Thomas ; Just, Ingo ; Rohrbeck,Astrid ;
Corrigendum: Potentiation of brain-derived neurotrophic factor-induced protection of spiral ganglion neurons by C3 exoenzyme/Rho inhibitor,
Switzerland,Front.Cell.Neurosci.,2022;16():1078962-10.3389
/fncel.2022.1078962 Reporting year:2022 | ID: RefID:25948-harre2022 Corrigendum:
Corrigendum
Haukamp,F. J. ; Gall,E. ; Hò,G. T. ; Hiemisch,W. ; Stieglitz,F.; Kuhn,J. ; Blasczyk,R. ; Pich,A.; Bade-Döding,C. ;
Deciphering the proteomics of HLA-B*57:01(+) antigen-presenting cells during abacavir medication,
Switzerland,J.Pers.Med.,2022;12(1):40-10.3390, /jpm12010040 Reporting year:2022 | ID: RefID:25968-haukamp2022unravelling
Original publication
Henkel,Daniel;
The receptor interaction of the Clostridioides difficile toxins TcdA and TcdB,
Hannover,,2021;():-VII, 99 pages : illustrations, diagrams, reporting year:2022 | ID: RefID:26012-henkel2021die
Dissertation
Maassen,H. ; Said,M. Y. ; Frenay,A. S. ; Koning,A. ; Post,A. ; Riphagen,I. J. ; Heiner-Fokkema,M. R. ; Drabert,K. ; Fernandez,B. O. ; Gans,R. O. B. ; van den Berg,E. ; Navis,G. ; Tsikas,D.; Feelisch,M. ; Bakker,S. J. L. ; van Goor,H. ;
Nitric oxide and long-term outcomes after kidney transplantation: Results of the TransplantLines cohort study,
United States,Nitric Oxide,2022;125-126():1-11 10.1016/j.niox.2022.05.005 Reporting year:2022 | ID: 11666
Original publication
Malfeld,Kathrin ; Armbrecht,Nina ; Pich,Andreas ; Volk,Holger A. ; Lenarz,Thomas ; Scheper,Verena ;
Prevention of noise-induced hearing loss in vivo: Continuous application of insulin-like growth factor 1 and its effect on inner ear synapses, auditory function and perilymph proteins,
Switzerland,Int.J.Mol.Sci.,2022;24(1):291-10.3390 /ijms24010291 Reporting year:2022 | ID: RefID:23508-malfeld2022prevention
Original publication
Mangan,Matthew S. J. ; Gorki,Friederike ; Krause,Karoline ; Heinz,Alexander ; Pankow,Anne ; Ebert,Thomas ; Jahn,Dieter ; Hiller,Karsten ; Hornung,Veit ; Maurer,Marcus ; Schmidt,Florian I. ; Gerhard,Ralf ; Latz,Eicke ;
Transcriptional licensing is required for pyrin inflammasome activation in human macrophages that is bypassed by mutations causing familial Mediterranean fever,
United States,PLoS Biol.,2022;20(11):-e3001351 10.1371/journal.pbio.3001351 Reporting year:2022 | ID: RefID:23516-mangan2022transcriptional
Original publication
Neumann-Schaal,M; Groß,U; Just,I; Jahn,D
The Deadly Secrets of C. difficile-Insights Into Host-Pathogen Interaction.
Front. Microbiol. 13:897612. doi: 10.3389/fmicb.2022.897612 (2022)
Editorial
Neumann-Schaal,Meina ; Groß,Uwe ; Just, Ingo ; Jahn,Dieter ;
The Deadly Secrets of C. difficile-Insights into Host-Pathogen Interaction, Volume II,
Switzerland,Front.Microbiol.,2022;13():896979-10.3389 /fmicb.2022.896979 Reporting year:2022 | ID: RefID:23740-neumann-schaal2022editorial:
Editorial
Nowakowska,M. B. ; Selby,K. ; Przykopanski,A.; Krüger,M. ; Krez,N.; Dorner,B. G. ; Dorner,M. B. ; Jin,R. ; Minton, N. P. ; Rummel,A.; Lindström,M. ;
Construction and validation of a safe Clostridium botulinum group II surrogate strain producing inactive botulinum neurotoxin type E, Toxoid,
England, Sci.Rep.,2022;12(1):1790-10.1038/s41598-022-05008-1 Reporting year:2022 | ID: RefID:23775-nowakowska2022construction
Original publication
Petersen,Lara ; Stroh,Svenja ; Schöttelndreier,Dennis ; Grassl,Guntram A. ; Rottner,Klemens ; Brakebusch,Cord ; Fahrer,Jörg ; Genth,Harald;
The essential role of Rac1 glucosylation in B-induced arrest of the G1-S transition by Clostridioides difficile toxin,,
Front Microbiol,2022;13():846215-10.3389 /fmicb.2022.846215 reporting year:2022 | ID: RefID:23897-petersen2022essential
Original publication
Piepgras,J. ; Rohrbeck,A.; Just, Ingo ; Bittner,S. ; Ahnert-Hilger,G. ; Höltje,M. ;
Enhancement of phosphorylation and transport activity of the neuronal glutamate transporter excitatory amino acid transporter 3 by C3bot and a 26mer C3bot peptide,
Switzerland,Front.Cell.Neurosci.,2022;16():860823-10.3389 /fncel.2022.860823 Reporting year:2022 | ID: RefID:23925-piepgras2022enhancement
Original publication
Reboll,M. R. ; Klede,S. ; Taft,M. H. ; Cai,C. L. ; Feld,L. J. ; Lavine,K. J. ; Koenig,A. L. ; Fleischauer,J. ; Meyer,J. ; Schambach,A. ; Niessen,H. W. ; Kosanke,M. ; van den Heuvel,J. ; Pich,A.; Bauersachs,J. ; Wu,X. ; Zheng,L. ; Wang,Y. ; Korf-Klingebiel,M. ; Pölten,F.; Wollert,K. C. ;
Meteorin-like promotes cardiac repair through endothelial KIT receptor tyrosine kinase,
United States,Science,2022;376(6599):1343-1347 10.1126/science.abn3027 Reporting year:2022 | ID: RefID:24037-reboll2022meteorin-like
Original publication
Schweitzer,T.; Genth,H.; Pich,A.;
The alpha-toxin of Clostridium novyi alters the proteome and phosphoproteome of HEp-2 cells,
Switzerland,Int.J.Mol.Sci.,2022;23(17):9939-10.3390 /ijms23179939 Reporting year:2022 | ID: RefID:24343-schweitzer2022clostridium
Original publication
Stieglitz,F.; Gerhard,R.; Hönig,R. ; Giehl,K. ; Pich,A.;
TcdB of Clostridioides difficile mediates RAS-dependent necrosis in epithelial cells,
Switzerland,Int.J.Mol.Sci.,2022;23(8):4258-10.3390 /ijms23084258 Reporting year:2022 | ID: RefID:24479-stieglitz2022tcdb
Original publication
Stieglitz,Florian;
LC-MS-based characterization of effects on signaling molecules induced by Clostridioides difficile toxins,
Hannover,,2022;():iv, 90 sheets, sheet v-viii : illustrations, diagrams, reporting year:2022 | ID: RefID:24480-stieglitz2022lc-ms-based
Dissertation
Tian,Songhai ; Xiong,Xiaozhe ; Zeng,Ji ; Wang,Siyu ; Tremblay,Benjamin Jean-Marie ; Chen,Peng ; Chen,Baohua ; Liu,Min ; Chen,Pengsheng ; Sheng,Kuanwei ; Zeve,Daniel ; Qi,Wanshu ; Breault,David T. ; Rodríguez,César ; Gerhard,Ralf ; Jin,Rongsheng ; Doxey,Andrew C. ; Dong,Min ;
Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants,
England,Nat.Commun.,2022;13(1):6786-10.1038/s41467-022-33964-9 Reporting year:2022 | ID: RefID:24582-tian2022identification
Original publication
Tsikas,D.; Redfors,B. ;
Pilot Study on Acute Effects of Pharmacological Intraperitoneal L-Homoarginine on Homeostasis of Lysine and Other Amino Acids in a Rat Model of Isoprenaline-Induced Takotsubo Cardiomyopathy,
Switzerland,Int.J.Mol.Sci.,2022;23(9):4734-10.3390/ijms23094734 Reporting year:2022 | ID: RefID:24608-tsikas2022pilot
Original publication
Tsikas,Dimitrios;
Determination of equilibria constants of arginine:glycine amidinotransferase (AGAT)-catalyzed reactions using concentrations of circulating amino acids,
Austria,Amino Acids,2022;():- 10.1007/s00726-022-03218-5, reporting year:2022 | ID: RefID:24610-tsikas2022determination
Original publication
Tsikas,Dimitrios ;
Homoarginine in health and disease,
England,Curr.Opin.Clin.Nutr.Metab.Care,2023;26(1):42-49, 10.1097/MCO.0000000000000889 Reporting year:2022 | ID: RefID:24609-tsikas2023homoarginine
Overview
Tsikas,Dimitrios; Editorial,,
Amino Acids,2022;54():481-484 10.1007/s00726-022-03164-2 Reporting year:2022 | ID: 11513
Editorial
Tsikas,Dimitrios ; Mikuteit,Marie ;
N-Acetyl-L-cysteine in human rheumatoid arthritis and its effects on nitric oxide (NO) and malondialdehyde (MDA): analytical and clinical considerations.
Amino Acids,2022;54(9):1251-1260, 10.1007/s00726-022-03185-x
Overview
van Dieken,A. ; Staecker,H. ; Schmitt,H. ; Harre,J. ; Pich,A. ; Roßberg,W. ; Lenarz,T. ; Durisin,M. ; Warnecke,A. ;
Bioinformatic Analysis of the Perilymph Proteome to Generate a Human Protein Atlas,
Switzerland,Front.Cell.Dev.Biol.,2022;10():847157-10.3389/fcell.2022.847157 Reporting year:2022 | ID: RefID:24649-van2022bioinformatic
Original publication
von Hanstein,Anna-Sophie ; Tsikas,Dimitrios; Lenzen,Sigurd ; Jörns,Anne ; Plötz,Thomas ;
Potentiation of Lipotoxicity in Human EndoC-betaH1 Beta-cells by Glucose is Dependent on the Structure of Free Fatty Acids,
Germany,Mol.Nutr.Food Res.,2023;():-e2200582, 10.1002/mnfr.202200582 Reporting year:2022 | ID: RefID:24703-from2023potentiation
Original publication
Wessig,A. K. ; Hoffmeister,L. ; Klingberg,A. ; Alberts,A. ; Pich,A. ; Brand,K. ; Witte,T. ; Neumann,K. ;
Natural antibodies and CRP drive anaphylatoxin production by urate crystals,
England,Sci.Rep.,2022;12(1):4483-10.1038/s41598-022-08311-z Reporting year:2022 | ID: RefID:24815-wessig2022natural
Original publication
Baskal,S. ; Bollenbach,A. ; Mels,C. ; Kruger,R. ; Tsikas,D.
Development, validation of a GC-MS method for the simultaneous measurement of amino acids, their PTM metabolites and AGEs in human urine, and application to the bi-ethnic ASOS study with special emphasis to lysine,
Austria,Amino Acids,2021;():-
Originalpublikation
Baskal,S. ; Bollenbach,A. ; Tsikas,D.
Two-Step Derivatization of Amino Acids for Stable-Isotope Dilution GC-MS Analysis: Long-Term Stability of Methyl Ester-Pentafluoropropionic Derivatives in Toluene Extracts
Switzerland,Molecules,2021;26(6):1726-
Original publication
Baskal,S. ; Bollenbach,A. ; Tsikas,D.
GC-MS Discrimination of Citrulline from Ornithine and Homocitrulline from Lysine by Chemical Derivatization: Evidence of Formation of N(5)-Carboxy-ornithine and N(6)-Carboxy-lysine
Switzerland,Molecules,2021;26(8):2301-
Original publication
Baskal,S. ; Büttner,P. ; Werner,S. ; Besler,C. ; Lurz,P. ; Thiele,H. ; Tsikas,D.
Profile of urinary amino acids and their post-translational modifications (PTM) including advanced glycation end-products (AGEs) of lysine, arginine and cysteine in lean and obese ZSF1 rats,
Austria, Amino Acids,2021;():-
Original publication
Baskal,S. ; Post,A. ; Kremer,D. ; Bollenbach,A. ; Bakker,S. J. L. ; Tsikas,D.
Urinary excretion of amino acids and their advanced glycation end-products (AGEs) in adult kidney transplant recipients with emphasis on lysine: furosine excretion is associated with cardiovascular and all-cause mortality,
Austria,Amino Acids,2021;():-
Original publication
Begou,O. ; Pavlaki,A. ; Deda,O. ; Bollenbach,A. ; Drabert,K. ; Gika,H. ; Farmaki,E. ; Dotis,J. ; Printza,N. ; Theodoridis,G. ; Tsikas,D.
Diminished Systemic Amino Acids Metabolome and Lipid Peroxidation in Ureteropelvic Junction Obstruction (UPJO) Infants Requiring Surgery,
Switzerland, J.Clin.Med.,2021;10(7):1467-
Original publication
Begou,O. ; Weber,K. ; Beckmann,B. ; Tsikas,D.
GC-MS Studies on Derivatization of Creatinine and Creatine by BSTFA and Their Measurement in Human Urine,
Switzerland, Molecules,2021;26(11):3206 [pii]-
Original publication
Bousnaki,M. ; Bakopoulou,A. ; Pich,A. ; Papachristou,E. ; Kritis,A. ; Koidis,P.
Mapping the Secretome of Dental Pulp Stem Cells Under Variable Microenvironmental Conditions
United States,Stem Cell.Rev.Rep.,2021;():-
Original publication
Büttner,P. ; Werner,S. ; Baskal,S. ; Tsikas,D. ; Adams,V. ; Lurz,P. ; Besler,C. ; Knauth,S. ; Bahls,M. ; Schwedhelm,E. ; Thiele,H.
Arginine metabolism and nitric oxide turnover in the ZSF1 animal model for heart failure with preserved ejection fraction,
England,Sci.Rep.,2021;11(1):20684-
Original publication
Chen,P. ; Zeng,J. ; Liu,Z. ; Thaker,H. ; Wang,S. ; Tian,S. ; Zhang,J. ; Tao,L. ; Gutierrez,C. B. ; Xing,L. ; Gerhard,R. ; Huang,L. ; Dong,M. ; Jin,R.
Structural basis for CSPG4 as a receptor for TcdB and a therapeutic target in Clostridioides difficile infection,
England,Nat.Commun.,2021;12(1):3748-
Original publication
Fischer, V., Just, I. (2021)
An integrated formula for determining the admission capacity in medical studies in reference to patients.
Contributions to higher education research, 43(4), 52-65.
Original publication
Harre,J. ; Heinkele,L. ; Steffens,M. ; Warnecke,A. ; Lenarz,T. ; Just,I. ; Rohrbeck,A.
Potentiation of Brain-Derived Neurotrophic Factor-Induced Protection of Spiral Ganglion Neurons by C3 Exoenzyme/Rho Inhibitor
Switzerland,Front.Cell.Neurosci.,2021;15():602897-
Original publication
Kendre,G. ; Marhenke,S. ; Lorz,G. ; Becker,D. ; Reineke-Plaass,T. ; Poth,T. ; Murugesan,K. ; Kühnel,F. ; Woller,N. ; Wirtz,R. M. ; Pich,A. ; Marquardt,J. U. ; Saborowski,M. ; Vogel,A. ; Saborowski,A.
The Co-mutational Spectrum Determines the Therapeutic Response in Murine FGFR2 Fusion-Driven Cholangiocarcinoma,
United States,Hepatology,2021;74(3):1357-1370
Original publication
Klepka,C. ; Sandmann,M. ; Tatge,H. ; Mangan,M. ; Arens,A. ; Henkel,D. ; Gerhard,R.
Impairment of lysosomal function by Clostridioides difficile TcdB
England,Mol.Microbiol.,2021;():-
Original publication
Korf-Klingebiel,M. ; Reboll,M. R. ; Polten,F. ; Weber,N. ; Jäckle,F. ; Wu,X. ; Kallikourdis,M. ; Kunderfranco,P. ; Condorelli,G. ; Giannitsis,E. ; Kustikova,O. S. ; Schambach,A. ; Pich,A. ; Widder,J. D. ; Bauersachs,J. ; van den Heuvel,J. ; Kraft,T. ; Wang,Y. ; Wollert,K. C.
Myeloid-Derived Growth Factor Protects Against Pressure Overload-Induced Heart Failure by Preserving Sarco/Endoplasmic Reticulum Ca(2+)-ATPase Expression in Cardiomyocytes,
United States,Circulation,2021;144(15):1227-1240
Original publication
Kukoc-Modun,L. ; Kraljević,T. ; Tsikas,D. ; Radić,N. ; Modun,D.
Determination of N-Acetyl-l-cysteine Ethyl Ester (NACET) by Flow Injection Analysis and Spectrophotometric Detection Using Different Thiol-Sensitive Ligands
Switzerland,Molecules,2021;26(22):6826-
Original publication
Marquardt,I. ; Jakob,J. ; Scheibel,J. ; Hofmann,J. D. ; Klawonn,F. ; Neumann-Schaal,M. ; Gerhard,R. ; Bruder,D. ; Jänsch,L.
Clostridioides difficile Toxin CDT Induces Cytotoxic Responses in Human Mucosal-Associated Invariant T (MAIT) Cells,
Switzerland,Front.Microbiol.,2021;12():752549-
Original publication
Mhlekude,B. ; Lenman,A. ; Sidoyi,P. ; Joseph,J. ; Kruppa,J. ; Businge,C. B. ; Mdaka,M. L. ; Konietschke,F. ; Pich,A. ; Gerold,G. ; Goffinet,C. ; Mall,A. S.
The barrier functions of crude cervical mucus plugs against HIV-1 infection in the context of cell-free and cell-to-cell transmission,
England,AIDS,2021;35(3):2105-2117
Original publication
Neumann,T. ; Krüger,M. ; Weisemann,J. ; Mahrhold,S. ; Stern,D. ; Dorner,M. B. ; Feraudet-Tarisse,C. ; Pöhlmann,C. ; Schulz,K. ; Messelhäusser,U. ; Rimek,D. ; Gessler,F. ; Elßner,T. ; Simon,S. ; Rummel,A. ; Dorner,B. G.
Innovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies,
Switzerland,Toxins (Basel),2021;13(4):266-
Original publication
Nickel,K. ; Wensorra,U. ; Wenck,H. ; Peters,N. ; Genth,H.
Evaluation of Immunomodulatory Responses and Changed Wound Healing in Type 2 Diabetes-A Study Exploiting Dermal Fibroblasts from Diabetic and Non-Diabetic Human Donors,
Switzerland,Cells,2021;10(11):2931-
Original publication
Ostermann,L. ; Maus,R. ; Stolper,J. ; Schütte,L. ; Katsarou,K. ; Tumpara,S. ; Pich,A. ; Mueller,C. ; Janciauskiene,S. ; Welte,T. ; Maus,U. A.
Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice,
United States,JCI Insight,2021;6(3):-
Original publication
Post,A. ; Bollenbach,A. ; Bakker,S. J. L. ; Tsikas,D. ;
Whole-body arginine dimethylation is associated with all-cause mortality in adult renal transplant recipients,
Austria, Amino Acids,2021;53(4):541-554
Original publication
Schenke,M. ; Prause,H. C. ; Bergforth,W. ; Przykopanski,A. ; Rummel,A. ; Klawonn,F. ; Seeger,B.
Human-Relevant Sensitivity of iPSC-Derived Human Motor Neurons to BoNT/A1 and B1,
Switzerland,Toxins (Basel),2021;13(8):585-
Original publication
Schmitt,H. A. ; Pich,A. ; Prenzler,N. K. ; Lenarz,T. ; Harre,J. ; Staecker,H. ; Durisin,M. ; Warnecke,A.
Personalized Proteomics for Precision Diagnostics in Hearing Loss: Disease-Specific Analysis of Human Perilymph by Mass Spectrometry,
United States,ACS Omega,2021;6(33):21241-21254
Original publication
Stieglitz,F. ; Gerhard,R. ; Pich,A. ;
The Binary Toxin of Clostridioides difficile Alters the Proteome and Phosphoproteome of HEp-2 Cells,
Switzerland,Front.Microbiol.,2021;12():725612-
Original publication
Stojanovic,S. D. ; Fuchs,M. ; Liang,C. ; Schmidt,K. ; Xiao,K. ; Just,A. ; Pfanne,A. ; Pich,A. ; Warnecke,G. ; Braubach,P. ; Petzold,C. ; Jonigk,D. ; Distler,J. H. W. ; Fiedler,J. ; Thum,T. ; Kunz,M.
Reconstruction of the miR-506-Quaking axis in Idiopathic Pulmonary Fibrosis using integrative multi-source bioinformatics,
England,Sci.Rep.,2021;11(1):12456-
Original publication
Tsikas,D.
Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology-part I
Austria, Amino Acids,2021;53(4):485-487
Editorial
Tsikas,D. ;
Comment on the article Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase,
England,IUCrJ,2021;8(Pt 2):327-328
Comment
Tsikas,D. ;
Extra-platelet low-molecular-mass thiols mediate the inhibitory action of S-nitrosoalbumin on human platelet aggregation via S-transnitrosylation of the platelet surface,
Austria, Amino Acids,2021;53(4):563-573
Original publication
Tsikas,D. ;
GC-MS Analysis of Biological Nitrate and Nitrite Using Pentafluorobenzyl Bromide in Aqueous Acetone: A Dual Role of Carbonate/Bicarbonate as an Enhancer and Inhibitor of Derivatization,
Switzerland,Molecules,2021;26(22):7003-
Original publication
Tsikas,D. ;
Homocysteine and copper ions: is their interaction responsible for cardiovascular-related damage?
Austria, Amino Acids,2021;53(8):1297-1298
Letter
Tsikas,D. ; Gambaryan,S. ;
Nitrous anhydrase activity of carbonic anhydrase II: cysteine is required for nitric oxide (NO) dependent phosphorylation of VASP in human platelets
England,J.Enzyme Inhib.Med.Chem.,2021;36(1):525-534
Original publication
Ückert,S. ; Richter,K. ; Fischer,K. D. ; Tsikas,D. ; Kuczyk,M. A.
Re-evaluation of the immunohistochemical distribution of isoforms of nitric oxide synthase in the human prostate: A light and electron microscopical study
Germany,Andrologia,2021;53(7):e14098-
Original publication
Walter,L. M. ; Rademacher,S. ; Pich,A. ; Claus,P.
Profilin2 regulates actin rod assembly in neuronal cells,
England,Sci.Rep.,2021;11(1):10287-
Original publication
Wang,Y. ; Polten,F. ; Jäckle,F. ; Korf-Klingebiel,M. ; Kempf,T. ; Bauersachs,J. ; Freitag-Wolf,S. ; Lichtinghagen,R. ; Pich,A. ; Wollert,K. C.
A mouse model of cardiogenic shock,
England,Cardiovasc.Res.,2021;117(12):2414-2415
Letter
Ahmadpour,Jamshid
Investigation of antibody formation against botulinum neurotoxin A in the therapy of movement disorders
Hannover,,2018;():4 uncounted pages, 76 pages : illustrations, -
Dissertation
Schneider,Carmen
Intracellular activity of the pathogenic domain of large clostridial glucosyltransferases
Hannover,,2021;():VII, 135 pages : illustrations, diagrams-
Dissertation
Weber,Kathrin
GC-MS-based studies on the importance of renal carbonic anhydrases for the reabsorption of nitrite and oxidative stress in humans
Hannover,,2020;():5 uncounted sheets, VI sheets, 102 sheets -
Dissertation
Hussein,Nali
C3-mediated effects in psoriasis on the Phenion 3D full-thickness skin model,
Hannover,,;():78 pages-
Master thesis
Langejürgen,Anna
The role of macropinocytosis in the cellular uptake of C. difficile toxin
Hannover,,;():74 Seiten-
Master thesis
von der Kammer,Urs
Presentation of the interaction of botulinum neurotoxins serotype A and E with their protein receptors synaptic vesicle glycoprotein C and A,
Hannover,,;():106 Seiten-
Master thesis
Adolf,A. ; Turko,P. ; Rohrbeck,A. ; Just,I. ; Vida,I. ; Ahnert-Hilger,G. ; Höltje,M.
The Higher Sensitivity of GABAergic Compared to Glutamatergic Neurons to Growth-Promoting C3bot Treatment Is Mediated by Vimentin
Switzerland,Front.Cell.Neurosci.,2020;14():596072-
Original publication
Alberts,A. ; Klingberg,A. ; Hoffmeister,L. ; Wessig,A. K. ; Brand,K. ; Pich,A. ; Neumann,K.
Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures
Switzerland,Front.Immunol.,2020;11():596103-
Original publication
Alberts,A. ; Klingberg,A. ; Wessig,A. K. ; Combes,C. ; Witte,T. ; Brand,K. ; Pich,A. ; Neumann,K.
C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1
England,Sci.Rep.,2020;10(1):6391-
Original publication
Becker,T. ; Pich,A. ; Tamm,S. ; Hedtfeld,S. ; Ibrahim,M. ; Altmüller,J. ; Dalibor,N. ; Toliat,M. R. ; Janciauskiene,S. ; Tümmler,B. ; Stanke,F.
Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B
England,Sci.Rep.,2020;10(1):22447-
Original publication
Begou,O. ; Drabert,K. ; Theodoridis,G. ; Tsikas,D.
GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine
China,J.Pharm.Anal.,2020;10(1):49-59
Original publication
Bollenbach,A. ; Gambaryan,S. ; Mindukshev,I. ; Pich,A. ; Tsikas,D.
GC-MS and LC-MS/MS pilot studies on the guanidine (N(G))-dimethylation in native, asymmetrically and symmetrically N(G)-dimethylated arginine-vasopressin peptides and proteins in human red blood cells
Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2020;1141():122024-
Original publication
Bollenbach,A. ; Schutte,A. E. ; Kruger,R. ; Tsikas,D.
An Ethnic Comparison of Arginine Dimethylation and Cardiometabolic Factors in Healthy Black and White Youth: The ASOS and African-PREDICT Studies Switzerland,J.Clin.Med.,2020;9(3):844.-
Original publication
Bollenbach,A. ; Tsikas,D.
Measurement of the tripeptides glutathione and ophthalmic acid by gas chromatography-mass spectrometry
United States,Anal.Biochem.,2020;():-
Original publication
Brinkmann,F. ; Hanusch,B. ; Ballmann,M. ; Mayorandan,S. ; Bollenbach,A. ; Chobanyan-Jürgens,K. ; Jansen,K. ; Schmidt-Choudhury,A. ; Derichs,N. ; Tsikas,D. ; Lücke,T.
Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results
Switzerland,J.Clin.Med.,2020;9(6):E2012 [pii]-
Original publication
Craig,A. ; M C Mels,C. ; Tsikas,D. ; Boeger,R. H. ; Schwedhelm,E. ; Schutte,A. E. ; Kruger,R.
Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study
England,J.Hum.Hypertens.,2021;35(11):985-993
Original publication
Craig,A. ; Mels,C. M. C. ; Schutte,A. E. ; Bollenbach,A. ; Tsikas,D. ; Schwedhelm,E. ; Kruger,R. ;
Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study
England,Hypertens.Res.,2021;44(1):71-79
Original publication
Craig,A. ; Mels,C. M. C. ; Schutte,A. E. ; Tsikas,D. ; Kruger,R. ;
Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies
Austria,Amino Acids,2020;52(4):639-648
Original publication
Cseko,K. ; Pecsi,D. ; Kajtar,B. ; Hegedus,I. ; Bollenbach,A. ; Tsikas,D. ; Szabo,I. L. ; Szabo,S. ; Helyes,Z.
Upregulation of the TRPA1 Ion Channel in the Gastric Mucosa after Iodoacetamide-Induced Gastritis in Rats: A Potential New Therapeutic Target
Switzerland,Int.J.Mol.Sci.,2020;21(16):E5591 [pii]-
Original publication
Deppe,J. ; Weisemann,J. ; Mahrhold,S. ; Rummel,A.
The 25 kDa HCN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity
Switzerland,Toxins (Basel),2020;12(12):-
Original publication
Hanusch,B. ; Brinkmann,F. ; Mayorandan,S. ; Chobanyan-Jürgens,K. ; Wiemers,A. ; Jansen,K. ; Ballmann,M. ; Schmidt-Choudhury,A. ; Bollenbach,A. ; Derichs,N. ; Tsikas,D. ; Lücke,T.
Local and Systemic Alterations of the L-Arginine/Nitric Oxide Pathway in Sputum, Blood, and Urine of Pediatric Cystic Fibrosis Patients and Effects of Antibiotic Treatment Switzerland,J.Clin.Med.,2020;9(12)::E3802-
Original publication
Henkel,D. ; Tatge,H. ; Schöttelndreier,D. ; Tao,L. ; Dong,M. ; Gerhard,R.
Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive
Switzerland,Toxins (Basel),2020;12(12):-
Original publication
Hensel,N. ; Raker,V. ; Förthmann,B. ; Buch,A. ; Sodeik,B. ; Pich,A. ; Claus,P.
The Proteome and Secretome of Cortical Brain Cells Infected With Herpes Simplex Virus
Switzerland,Front.Neurol.,2020;11():844-
Original publication
Herkt,M. ; Foinquinos,A. ; Batkai,S. ; Thum,T. ; Pich,A.
Pharmacokinetic Studies of Antisense Oligonucleotides Using MALDI-TOF Mass Spectrometry
Switzerland,Front.Pharmacol.,2020;11():220-
Original publication
Ho,G. T. ; Hiemisch,W. ; Pich,A. ; Behrens,G. M. N. ; Blasczyk,R. ; Bade-Doeding,C.
The Loss of HLA-F/KIR3DS1 Ligation Is Mediated by Hemoglobin Peptides
Switzerland,Int.J.Mol.Sci.,2020;21(21):8012-
Original publication
Hobuss,L. ; Foinquinos,A. ; Jung,M. ; Kenneweg,F. ; Xiao,K. ; Wang,Y. ; Zimmer,K. ; Remke,J. ; Just,A. ; Nowak,J. ; Schmidt,A. ; Pich,A. ; Mazlan,S. ; Reamon-Buettner,S. M. ; Ramos,G. C. ; Frantz,S. ; Viereck,J. ; Loyer,X. ; Boulanger,C. ; Wollert,K. C. ; Fiedler,J. ; Thum,T.
Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19 England,J.Mol.Cell.Cardiol.,2020;146():43-59
Originalpublication
Hollwedel,F. D. ; Maus,R. ; Stolper,J. ; Khan,A. ; Stocker,B. L. ; Timmer,M. S. M. ; Lu,X. ; Pich,A. ; Welte,T. ; Yamasaki,S. ; Maus,U. A.
Overexpression of Macrophage-Inducible C-Type Lectin Mincle Aggravates Proinflammatory Responses to Streptococcus pneumoniae with Fatal Outcome in Mice
United States,J.Immunol.,2020;205(12):3390-3399
Original publication
Jansen,K. ; Hanusch,B. ; Pross,S. ; Hanff,E. ; Drabert,K. ; Bollenbach,A. ; Dugave,I. ; Carmann,C. ; Siefen,R. G. ; Emons,B. ; Juckel,G. ; Legenbauer,T. ; Tsikas,D. ; Lücke,T.
Enhanced Nitric Oxide (NO) and Decreased ADMA Synthesis in Pediatric ADHD and Selective Potentiation of NO Synthesis by Methylphenidate
Switzerland,J.Clin.Med.,2020;9(1):pii: E175-
Original publication
Jansing,J. C. ; Fiedler,J. ; Pich,A. ; Viereck,J. ; Thum,T. ; Mühlfeld,C. ; Brandenberger,C.
miR-21-KO Alleviates Alveolar Structural Remodeling and Inflammatory Signaling in Acute Lung Injury
Switzerland,Int.J.Mol.Sci.,2020;21(3):E822-
Original publication
Kedia,G. T. ; Ückert,S. ; Tsikas,D. ; Becker,A. J. ; Kuczyk,M. A. ; Bannowsky,A.
The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts
Switzerland,J.Clin.Med.,2020;9(9):E2987-
Overview
Kropp,K. A. ; Srivaratharajan,S. ; Ritter,B. ; Yu,P. ; Krooss,S. ; Polten,F. ; Pich,A. ; Alcami,A. ; Viejo-Borbolla,A.
Identification of the Cleavage Domain within Glycoprotein G of Herpes Simplex Virus Type 2
Switzerland,Viruses,2020;12(12):E1428 [pii]-
Original publication
Melzer,C. ; Jacobs,R. ; Dittmar,T. ; Pich,A. ; von der Ohe,J. ; Yang,Y. ; Hass,R.
Reversible Growth-Arrest of a Spontaneously-Derived Human MSC-Like Cell Line
Switzerland,Int.J.Mol.Sci.,2020;21(13):E4752.-
Originalpublication
Neu,A. ; Hornig,S. ; Sasani,A. ; Isbrandt,D. ; Gerloff,C. ; Tsikas,D. ; Schwedhelm,E. ; Choe,C. U.
Creatine, guanidinoacetate and homoarginine in statin-induced myopathy
Austria,Amino Acids,2020;52(6-7):1067-1069
Letter
Schöttelndreier,D. ; Langejürgen,A. ; Lindner,R. ; Genth,H.
Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor Switzerland,Front.Cell.Infect.Microbiol.,2020;10():565465-
Originalpublication
Stojanovic,S. D. ; Fuchs,M. ; Fiedler,J. ; Xiao,K. ; Meinecke,A. ; Just,A. ; Pich,A. ; Thum,T. ; Kunz,M.
Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts
Switzerland,Int.J.Mol.Sci.,2020;21(11):-
Original publication
Stojanovic,S. D. ; Fuchs,M. ; Kunz,M. ; Xiao,K. ; Just,A. ; Pich,A. ; Bauersachs,J. ; Fiedler,J. ; Sedding,D. ; Thum,T.
Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells
Switzerland,Front.Physiol.,2020;11():520-
Original publication
Tian,S. ; Liu,Y. ; Wu,H. ; Liu,H. ; Zeng,J. ; Choi,M. Y. ; Chen,H. ; Gerhard,R. ; Dong,M.
Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL
United States,Cell.Host Microbe,2020;27(5):782-792.e7
Original publication
Tsikas,D.
GC-MS approach revealing hidden nitrite reactions in hemolysate using (18)O-labeled nitrite and cysteine-based thiols
United States,Anal.Biochem.,2020;():114025-
Original publication
Tsikas,D.
Rat liver glutathione S-transferase-catalyzed conjugation of glutathione to the endogenous epoxides of oleic acid and cholesterol
United States,Anal.Biochem.,2020;():113994-
Original publication
Tsikas,D.
Urinary Dimethylamine (DMA) and Its Precursor Asymmetric Dimethylarginine (ADMA) in Clinical Medicine, in the Context of Nitric Oxide (NO) and Beyond
Switzerland,J.Clin.Med.,2020;9(6):-
Overview
Tsikas,D. ; Surdacki,A.
Biotransformation of organic nitrates by glutathione S-transferases and other enzymes: An appraisal of the pioneering work by William B. Jakoby
United States,Anal.Biochem.,2020;():113993-
Overview
Yepes-Calderon,M. ; Sotomayor,C. G. ; Gans,R. O. B. ; Berger,S. P. ; Leuvenink,H. G. D. ; Tsikas,D. ; Rodrigo,R. ; Navis,G. J. ; Bakker,S. J. L.
Post-transplant plasma malondialdehyde is associated with cardiovascular mortality in renal transplant recipients: a prospective cohort study
England,Nephrol.Dial.Transplant,2020;35(3):512-519
Original publication
Schöttelndreier,Dennis
Expression and cellular internalization of Clostridium difficile Toxin A and Toxin B receptors
Hannover,,2020;():VI, 75 sheets : illustrations, diagrams-
Dissertation
Kriedemann,Nils
LC-MS based proteomic analysis of human endomyocardial heart biopsies of heart failure patients
Hannover,,2020;():-
Master thesis
Scheele,Marven
Integration of the SpyCatcher-SpyTag system in Clostridioides difficile Toxin B
Hannover,,2020;():68 pages-
Master thesis
Bogutzki,A., Naue,N., Litz,L., Pich,A., Curth,U.
E. coli primase and DNA polymerase III holoenzymes are able to bind concurrently to a primed template during DNA replication.
Sci.Rep.2019;9(1):14460-
http://dx.doi.org/10.1038/s41598-019-51031-0
Originalpublikation
Bollenbach,A., Bakker,S. J. L., Tsikas,D.
GC-MS measurement of biological N(G)-hydroxy-L-arginine, a stepmotherly investigated endogenous nitric oxide synthase substrate and arginase inhibitor
Amino Acids,2019;51(4):627-64
http://dx.doi.org/10.1007/s00726-018-02695-x
Original publication
Bollenbach,A., Cordts,K., Hanff,E., Atzler,D., Choe,C. U., Schwedhelm,E., Tsikas,D.
Evidence by GC-MS that lysine is an arginase-catalyzed metabolite of homoarginine in vitro and in vivo in humans
Anal.Biochem.,2019;577():59-66
http://dx.doi.org/10.1016/j.ab.2019.04.019
Originalpublication
Bollenbach,A., Hanff,E., Brunner,G., Tsikas,D.
Asymmetric dimethylation and citrullination of proteinic arginine and homoarginine synthesis in human Helicobacter pylori infection
Amino Acids,2019;51(6):961-971
http://dx.doi.org/10.1007/s00726-019-02737-y
Original publication
Bollenbach,A., Huneau,J. F., Mariotti,F., Tsikas,D.
Asymmetric and Symmetric Protein Arginine Dimethylation: Concept and Postprandial Effects of High-Fat Protein Meals in Healthy Overweight Men
Nutrients,2019;11(7):E1463-
http://dx.doi.org/10.3390/nu11071463
Original publication
Bollenbach,A., Tsikas,D., Lenzen,S., Jörns,A.
Asymmetric dimethylation and citrullination in the LEW.1AR1-iddm rat, an animal model of human type 1 diabetes, and effects of anti-TCR/anti-TNF-alpha antibody-based therapy
Amino Acids,2020;52(1):103-110
http://dx.doi.org/10.1007/s00726-019-02811-5
Original publication
Erdmann,J., Thöming,J. G., Pohl,S., Pich,A., Lenz,C., Häussler,S.
The Core Proteome of Biofilm-Grown Clinical Pseudomonas aeruginosa Isolates
Cells,2019;8(10):E1129 [pii]-
http://dx.doi.org/10.3390/cells8101129
Original publication
Grund,A., Szaroszyk,M., Korf-Klingebiel,M., Malek Mohammadi,M., Trogisch,F. A., Schrameck,U., Gigina,A., Tiedje,C., Gaestel,M., Kraft,T., Hegermann,J., Batkai,S., Thum,T., Perrot,A., Remedios,C. D., Riechert,E., Völkers,M., Doroudgar,S., Jungmann,A., Bauer,R., Yin,X., Mayr,M., Wollert,K. C., Pich,A., Xiao,H., Katus,H. A., Bauersachs,J., Müller,O. J., Heineke,J.
TIP30 counteracts cardiac hypertrophy and failure by inhibiting translational elongation
EMBO Mol.Med.,2019;11(10):e10018-
http://dx.doi.org/10.15252/emmm.201810018
Original publication
Hanff,E., Bollenbach,A., Beckmann,B., Brunner,G., Tsikas,D.
GC-MS measurement of spermidine and putrescine in serum of elderly subjects: intriguing association between spermidine and homoarginine
Amino Acids,2020;52(2):225-234
http://dx.doi.org/10.1007/s00726-019-02786-3
Original publication
Hanff,E., Ruben,S., Kreuzer,M., Bollenbach,A., Kayacelebi,A. A., Das,A. M., von Versen-Höynck,F., von Kaisenberg,C., Haffner,D., Ückert,S., Tsikas,D.
Development and validation of GC-MS methods for the comprehensive analysis of amino acids in plasma and urine and applications to the HELLP syndrome and pediatric kidney transplantation: evidence of altered methylation, transamidination, and arginase activity
Amino Acids,2019;51(3):529-547
http://dx.doi.org/10.1007/s00726-018-02688-w
Original publication
Hanff,E., Said,M. Y., Kayacelebi,A. A., Post,A., Minovic,I., van den Berg,E., de Borst,M. H., van Goor,H., Bakker,S. J. L., Tsikas,D.
High plasma guanidinoacetate-to-homoarginine ratio is associated with high all-cause and cardiovascular mortality rate in adult renal transplant recipients
Amino Acids,2019;51(10-12):1485-1499
http://dx.doi.org/10.1007/s00726-019-02783-6
Original publication
Ho,G. T., Heinen,F. J., Blasczyk,R., Pich,A., Bade-Doeding,C.
HLA-F Allele-Specific Peptide Restriction Represents an Exceptional Proteomic Footprint
Int.J.Mol.Sci.,2019;20(22):E5572.-
http://dx.doi.org/10.3390/ijms20225572
Original publication
Kluge,A., Rangrez,A. Y., Kilian,L. S., Pott,J., Bernt,A., Frauen,R., Rohrbeck,A., Frey,N., Frank,D.
Rho-family GTPase 1 (Rnd1) is a biomechanical stress-sensitive activator of cardiomyocyte hypertrophy
J.Mol.Cell.Cardiol.,2019;129():130-143
http://dx.doi.org/10.1016/j.yjmcc.2019.01.028
Original publication
Kutschenko,A., Weisemann,J., Kollewe,K., Fiedler,T., Alvermann,S., Böselt,S., Escher,C., Garde,N., Gingele,S., Kaehler,S. B., Karachai,R., Krüger,T. H. C., Sikorra,S., Tacik,P., Wegner,F., Wollmann,J., Bigalke,H., Wohlfarth,K., Rummel,A.
Botulinum neurotoxin serotype D - A potential treatment alternative for BoNT/A and B non-responding patients
Clin.Neurophysiol.,2019;130(6):1066-1073
http://dx.doi.org/10.1016/j.clinph.2019.02.007
Original publication
Nebl,J., Drabert,K., Haufe,S., Wasserfurth,P., Eigendorf,J., Tegtbur,U., Hahn,A., Tsikas,D.
Exercise-Induced Oxidative Stress, Nitric Oxide and Plasma Amino Acid Profile in Recreational Runners with Vegetarian and Non-Vegetarian Dietary Patterns
Nutrients,2019;11(8):E1875-
http://dx.doi.org/10.3390/nu11081875
Original publication
Pich,A., Junemann,J., Stieglitz,F., Schweitzer,T.
Clostridioides difficile toxins alter the proteome of intestinal cells
BIOspektrum,2019;25(6):633-636
http://dx.doi.org/10.1007/s12268-019-0213-0
Original publication
Post,A., Said,M. Y., Gomes-Neto,A. W., van der Krogt,J., de Blaauw,P., Berger,S. P., Geleijnse,J. M., Borgonjen,K., van den Berg,E., van Goor,H., Rimbach,G., Kema,I. P., Tsikas,D., Heiner-Fokkema,M. R., Bakker,S. J. L.
Urinary Taurine Excretion and Risk of Late Graft Failure in Renal Transplant Recipients
Nutrients,2019;11(9):E2212-
http://dx.doi.org/10.3390/nu11092212
Original publication
Post,A., Tsikas,D., Bakker,S. J. L.
Creatine is a Conditionally Essential Nutrient in Chronic Kidney Disease: A Hypothesis and Narrative Literature Review
Nutrients,2019;11(5):E1044-
http://dx.doi.org/10.3390/nu11051044
Overview
Rahardjo,H. E., Ückert,S., Tsikas,D., Hedlund,P., Bannowsky,A., Kuczyk,M. A., Kedia,G. T.
Arginase enzymes in the human prostate: A molecular biological and immunohistochemical approach
Andrologia,2019;51(9):e13349-
http://dx.doi.org/10.1111/and.13349
Original publication
Said,M. Y., Bollenbach,A., Minovic,I., van Londen,M., Frenay,A. R., de Borst,M. H., van den Berg,E., Kayacelebi,A. A., Tsikas,D., van Goor,H., Navis,G., Bakker,S. J. L.
Plasma ADMA, urinary ADMA excretion, and late mortality in renal transplant recipients
Amino Acids,2019;51(6):913-927
http://dx.doi.org/10.1007/s00726-019-02725-2
Original publication
Said,M. Y., Douwes,R. M., van Londen,M., Minovic,I., Frenay,A. R., de Borst,M. H., van den Berg,E., Heiner-Fokkema,M. R., Kayacelebi,A. A., Bollenbach,A., van Goor,H., Navis,G., Tsikas,D., Bakker,S. J. L.
Effect of renal function on homeostasis of asymmetric dimethylarginine (ADMA): studies in donors and recipients of renal transplants
Amino Acids,2019;51(3):565-575
http://dx.doi.org/10.1007/s00726-018-02693-z
Original publication
Sasani,A., Hornig,S., Grzybowski,R., Cordts,K., Hanff,E., Tsikas,D., Böger,R., Gerloff,C., Isbrandt,D., Neu,A., Schwedhelm,E., Choe,C. U.
Muscle phenotype of AGAT- and GAMT-deficient mice after simvastatin exposure
Amino Acids,2020;52(1):73-85
http://dx.doi.org/10.1007/s00726-019-02812-4
Original publication
Schoenherr,C., Wohlan,K., Dallmann,I., Pich,A., Hegermann,J., Ganser,A., Hilfiker-Kleiner,D., Heidenreich,O., Scherr,M., Eder,M.
Stable depletion of RUNX1-ETO in Kasumi-1 cells induces expression and enhanced proteolytic activity of Cathepsin G and Neutrophil Elastase
PLoS One,2019;14(12):e0225977-
http://dx.doi.org/10.1371/journal.pone.0225977
Original publication
Simper,G. S., Gräser,L. S., Celik,A. A., Kuhn,J., Kunze-Schumacher,H., Ho,G. T., Blasczyk,R., Pich,A., Bade-Doeding,C.
The Mechanistic Differences in HLA-Associated Carbamazepine Hypersensitivity
Pharmaceutics,2019;11(10):pii: E536-
http://dx.doi.org/10.3390/pharmaceutics11100536
Original publication
Sonnenschein,K., Fiedler,J., Pfanne,A., Just,A., Mitzka,S., Geffers,R., Pich,A., Bauersachs,J., Thum,T.
Therapeutic modulation of RNA-binding protein Rbm38 facilitates re-endothelialization after arterial injury Cardiovasc.Res.,2019;115(12):1804-1810
http://dx.doi.org/10.1093/cvr/cvz063
Original publication
Tao,L., Tian,S., Zhang,J., Liu,Z., Robinson-McCarthy,L., Miyashita,S. I., Breault,D. T., Gerhard,R., Oottamasathien,S., Whelan,S. P. J., Dong,M.
Sulfated glycosaminoglycans and low-density lipoprotein receptor contribute to Clostridium difficile toxin A entry into cells
Nat.Microbiol.,2019;4(10):1760-1769
http://dx.doi.org/10.1038/s41564-019-0464-z
Original publication
Tsikas,D., Bollenbach,A., Hanff,E., Beckmann,B., Redfors,B.
Synthesis of homoagmatine and GC-MS analysis of tissue homoagmatine and agmatine: evidence that homoagmatine but not agmatine is a metabolite of pharmacological L-homoarginine in the anesthetized rat
Amino Acids,2020;52(2):235-245
http://dx.doi.org/10.1007/s00726-019-02808-0
Original publication
Ückert,S., Kedia,G. T., Tsikas,D., Simon,A., Bannowsky,A., Kuczyk,M. A.
Emerging drugs to target lower urinary tract symptomatology (LUTS)/benign prostatic hyperplasia (BPH): focus on the prostate,Germany,World J.Urol.,2020;38(6):1423-1435
http://dx.doi.org/10.1007/s00345-019-02933-1
Overview
von Berg,L., Stern,D., Pauly,D., Mahrhold,S., Weisemann,J., Jentsch,L., Hansbauer,E. M., Müller,C., Avondet,M. A., Rummel,A., Dorner,M. B., Dorner,B. G.
Functional detection of botulinum neurotoxin serotypes A to F by monoclonal neoepitope-specific antibodies and suspension array technology
Sci.Rep.,2019;9(1):5531-
http://dx.doi.org/10.1038/s41598-019-41722-z
Original publication
von Berg,L., Stern,D., Weisemann,J., Rummel,A., Dorner,M. B., Dorner,B. G.
Optimization of SNAP-25 and VAMP-2 Cleavage by Botulinum Neurotoxin Serotypes A-F Employing Taguchi Design-of-Experiments
Toxins (Basel),2019;11(10):E588-
http://dx.doi.org/10.3390/toxins11100588
Original publication
Welz,B., Bikker,R., Junemann,J., Christmann,M., Neumann,K., Weber,M., Hoffmeister,L., Preuss,K., Pich,A., Huber,R., Brand,K.
Proteome and Phosphoproteome Analysis in TNF Long Term-Exposed Primary Human Monocytes
Int.J.Mol.Sci.,2019;20(5):E1241-
http://dx.doi.org/10.3390/ijms20051241
Original publication
Wieczorek-Surdacka,E., Hanff,E., Chyrchel,B., Kuzniewski,M., Surdacki,A., Tsikas,D.
Distinct associations between plasma osteoprotegerin, homoarginine and asymmetric dimethylarginine in chronic kidney disease male patients with coronary artery disease
Amino Acids,2019;51(6):977-982
http://dx.doi.org/10.1007/s00726-019-02738-x
Original publication
Zeleny,R., Rummel,A., Jansson,D., Dorner,B. G.
Challenges in the Development of Reference Materials for Protein Toxins. In: Applications in Forensic Proteomics: Protein Identification and Profiling 2019; 1339: 185-202
http://dx.doi.org/doi:10.1021/bk-2019-1339.ch012
Book contribution, monograph
Abere,B., Samarina,N., Gramolelli,S., Rückert,J., Gerold,G., Pich,A.,Schulz,T. F.
Kaposi's Sarcoma-Associated Herpesvirus Nonstructural Membrane Protein pK15 Recruits the Class II Phosphatidylinositol 3-kinase PI3K-C2alpha To Activate Productive Viral Replication
J.Virol. 2018; 92(17):e00544-18-
Original publication
http://dx.doi.org/10.1128/JVI.00544-18
Adolf,A., Rohrbeck,A., Münster-Wandowski,A., Johansson,M., Kuhn,H. G., Kopp,M. A., Brommer,B., Schwab,J. M., Just,I., Ahnert-Hilger,G., Höltje,M.,
Release of astroglial vimentin by extracellular vesicles: Modulation of binding and internalization of C3 transferase in astrocytes and neurons.
Glia 2019; 67(4):703-717
Original publication
http://dx.doi.org/10.1002/glia.23566
Aye,R., Weldearegay,Y. B., Lutta,H. O., Chuma,F., Pich,A., Jores,J., Meens,J., Naessens,J.
Identification of targets of monoclonal antibodies that inhibit adhesion and growth in Mycoplasma mycoides subspecies mycoides.
Vet.Immunol.Immunopathol. 2018; 204(11-18)
Original publication
http://dx.doi.org/10.1016/j.vetimm.2018.09.002
Beer,L. A., Tatge,H., Reich,N., Tenspolde,M., Olling,A., Goy,S., Rottner,K., Alekov,A. K., Gerhard,R.
Early cell death induced by Clostridium difficile TcdB: Uptake and Rac1-glucosylation kinetics are decisive for cell fate.
Cell.Microbiol. 2018; 20(10):e12865-
Original publication
http://dx.doi.org/10.1111/cmi.12865
Beer,L. A., Tatge,H., Schneider,C., Ruschig,M., Hust,M., Barton,J., Thiemann,S., Fühner,V., Russo,G., Gerhard,R.
The Binary Toxin CDT of Clostridium difficile as a Tool for Intracellular Delivery of Bacterial Glucosyltransferase Domains.
Toxins (Basel) 2018; 10(6):E225-
Original publication
http://dx.doi.org/10.3390/toxins10060225
Bollenbach,A., Hanff,E., Beckmann,B., Kruger,R., Tsikas,D.,
GC-MS quantification of urinary symmetric dimethylarginine (SDMA), a whole-body symmetric l-arginine methylation index.
Anal Biochem. 2018; 556(40-44)
Original publication
http://dx.doi.org/10.1016/j.ab.2018.06.021
Bollenbach,A., Hanff,E., Tsikas,D.
Investigation of N(G)-hydroxy-l-arginine interference in the quantitative determination of nitrite and nitrate in human plasma and urine by GC-NICI-MS
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1100-1101(174-178)
Original publication
http://dx.doi.org/10.1016/j.jchromb.2018.10.007
Bollenbach,A., Hanff,E., Tsikas,D.
Utility of homoarginine in the GC-MS quantification of asymmetric dimethylarginine (ADMA) in human serum proteins.
Anal Biochem. 2018; 563(67-70)
Original publication
http://dx.doi.org/10.1016/j.ab.2018.10.012
Bollenbach,A., Tsikas,D.
Pharmacological activation of dimethylarginine dimethylaminohydrolase (DDAH) activity by inorganic nitrate and DDAH inhibition by N(G)-hydroxy-L-arginine, N(omega),N(omega)-dimethyl-L-citrulline and N(omega),N(omega)-dimethyl-N(delta)-hydroxy-L-citrulline: results and overview.
Amino Acids 2019; 51(3):483-494
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http://dx.doi.org/10.1007/s00726-018-2684-6
Chung,S. Y., Schöttelndreier,D., Tatge,H., Fühner,V., Hust,M., Beer,L. A., Gerhard,R.
The Conserved Cys-2232 in Clostridioides difficile Toxin B Modulates Receptor Binding
Front.Microbiol. 2018; 9(2314-
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http://dx.doi.org/10.3389/fmicb.2018.02314
Erdmann,J., Preusse,M., Khaledi,A., Pich,A., Häussler,S.
Environment-driven changes of mRNA and protein levels in Pseudomonas aeruginosa.
Environ.Microbiol. 2018; 20(11):3952-3963
Original publication
http://dx.doi.org/10.1111/1462-2920.14419
Finkel,A., Röhrich,M. A., Maassen,N., Lützow,M., Blau,L. S., Hanff,E., Tsikas,D., Maassen,M., Long-term effects of NO3(-) on the relationship between oxygen uptake and power after 3 weeks of supplemented HIHV training
J.Appl.Physiol.(1985) 2018; 125(6):1997-2007
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http://dx.doi.org/10.1152/japplphysiol.00176.2018
Fischer,V., Dudzinska,A., Just,I.
The impact of the program structure at Hannover Medical School on academic success in medical studies
GMS J.Med.Educ. 2018; 35(2):Doc22-
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http://dx.doi.org/10.3205/zma001169
Genth,H., Junemann,J., Lämmerhirt,C. M., Lücke,A. C., Schelle,I., Just,I., Gerhard,R., Pich,A.
Difference in Mono-O-Glucosylation of Ras Subtype GTPases Between Toxin A and Toxin B From Clostridioides difficile Strain 10463 and Lethal Toxin From Clostridium sordellii Strain 6018
Front.Microbiol. 2018; 9(3078-
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http://dx.doi.org/10.3389/fmicb.2018.03078
Hanff,E., Hafner,P., Bollenbach,A., Bonati,U., Kayacelebi,A. A., Fischer,D., Tsikas,D.
Effects of single and combined metformin and L-citrulline supplementation on L-arginine-related pathways in Becker muscular dystrophy patients: possible biochemical and clinical implications
Amino Acids 2018; 50(10):1391-1406
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http://dx.doi.org/10.1007/s00726-018-2614-7
Hanff,E., Zinke,M., Böhmer,A., Niebuhr,J., Maassen,M., Endeward,V., Maassen,N., Tsikas,D.
GC-MS determination of nitrous anhydrase activity of bovine and human carbonic anhydrase II and IV
Anal.Biochem. 2018; 550(132-136)
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http://dx.doi.org/10.1016/j.ab.2018.05.001
Junemann,J., Just,I., Gerhard,R., Pich,A.
Quantitative Phosphoproteome Analysis of Clostridioides difficile Toxin B Treated Human Epithelial Cells
Front.Microbiol. 2018; 9(3083-
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http://dx.doi.org/10.3389/fmicb.2018.03083
Just,I., Fischer,V.
Examinations at Hannover Medical School - How to get from actual to target?
Wien.Med.Wochenschr. 2019; 169(5-6):119-125
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http://dx.doi.org/10.1007/s10354-018-0663-x
Lam,K. H., Sikorra,S., Weisemann,J., Maatsch,H., Perry,K., Rummel,A., Binz,T., Jin,R.
Structural and biochemical characterization of the protease domain of the mosaic botulinum neurotoxin type HA
Pathog.Dis. 2018; 76(4):10.1093/femspd/fty044-
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http://dx.doi.org/10.1093/femspd/fty044
Mehner-Breitfeld,D., Rathmann,C., Riedel,T., Just,I., Gerhard,R., Overmann,J., Brüser,T.
Evidence for an Adaptation of a Phage-Derived Holin/Endolysin System to Toxin Transport in Clostridioides difficile
Front.Microbiol. 2018; 9(2446-
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http://dx.doi.org/10.3389/fmicb.2018.02446
Montag,J., Kowalski,K., Makul,M., Ernstberger,P., Radocaj,A., Beck,J., Becker,E., Tripathi,S., Keyser,B., Mühlfeld,C., Wissel,K., Pich,A., van der Velden,J., Dos Remedios,C. G., Perrot,A., Francino,A., Navarro-Lopez,F., Brenner,B., Kraft,T.
Burst-Like Transcription of Mutant and Wildtype MYH7-Alleles as Possible Origin of Cell-to-Cell Contractile Imbalance in Hypertrophic Cardiomyopathy
Front.Physiol. 2018; 9(359-
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http://dx.doi.org/10.3389/fphys.2018.00359
Rahardjo,H. E., Ückert,S., Bannowsky,A., Tsikas,D., Becker,A. J., Kuczyk,M. A.
Course of transforming growth factor ss1 in the systemic and cavernous blood of healthy males through different penile conditions
Andrologia 2019; 51(1):e13150-
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http://dx.doi.org/10.1111/and.13150
Schöttelndreier,D., Seeger,K., Grassl,G. A., Winny,M. R., Lindner,R., Genth,H.
Expression and (Lacking) Internalization of the Cell Surface Receptors of Clostridioides difficile Toxin B
Front.Microbiol. 2018; 9(1483-
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http://dx.doi.org/10.3389/fmicb.2018.01483
Schröder,A., Benski,A., Oltmanns,A., Just,I., Rohrbeck,A., Pich,A.
MS-based quantification of RhoA/B and RhoC ADP-ribosylation
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1092(268-271)
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http://dx.doi.org/S1570-0232(18)30604-4
Shahin,P., Rahardjo,H. E., Bannowsky,A., Tsikas,D., Sohn,M., Kuczyk,M. A., Ückert,S.
Endopeptidase inhibition attenuates the contraction induced by big endothelin-1 of isolated human penile erectile tissue
Andrologia 2018; 50(5):e13008-
Original publication
http://dx.doi.org/10.1111/and.13008
Sikorra,S., Skiba,M., Dorner,M. B., Weisemann,J., Weil,M., Valdezate,S., Davletov,B., Rummel,A., Dorner,B. G., Binz,T.
Botulinum Neurotoxin F Subtypes Cleaving the VAMP-2 Q(58)(-)K(59) Peptide Bond Exhibit Unique Catalytic Properties and Substrate Specificities
Toxins (Basel) 2018; 10(8):E311-
Original publication
http://dx.doi.org/10.3390/toxins10080311
Stern,D., Weisemann,J., Le Blanc,A., von Berg,L., Mahrhold,S., Piesker,J., Laue,M., Luppa,P. B., Dorner,M. B., Dorner,B. G., Rummel,A.
A lipid-binding loop of botulinum neurotoxin serotypes B, DC and G is an essential feature to confer their exquisite potency
PLoS Pathog. 2018; 14(5):e1007048-
Original publication
http://dx.doi.org/10.1371/journal.ppat.1007048
Tan,X., Xu,A., Zhao,T., Zhao,Q., Zhang,J., Fan,C., Deng,Y., Freywald,A., Genth,H., Xiang,J.,
Simulated microgravity inhibits cell focal adhesions leading to reduced melanoma cell proliferation and metastasis via FAK/RhoA-regulated mTORC1 and AMPK pathways
Sci.Rep. 2018; 8(1):3769-
Original publication
http://dx.doi.org/10.1038/s41598-018-20459-1
Tsikas,D.,
Bioanalytical method validation of endogenous substances according to guidelines by the FDA and other organizations: Basic need to specify concentration ranges
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2018; 1093-1094(80-81)
Letter
http://dx.doi.org/10.1016/j.jchromb.2018.07.005
Tsikas,D., Bollenbach,A., Hanff,E., Kayacelebi,A. A.
Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and homoarginine (hArg): the ADMA, SDMA and hArg paradoxes
Cardiovasc.Diabetol. 2018; 17(1):1-
Comment
http://dx.doi.org/10.1186/s12933-017-0656-x
Tsikas,D., Hanff,E.
Measurement of S -Nitrosoglutathione in Plasma by Liquid Chromatography-Tandem Mass Spectrometry Methods
Mol.Biol. 2018; 1747(113-129
Original publication
http://dx.doi.org/10.1007/978-1-4939-7695-9_10
Tsikas,D., Hanff,E., Bollenbach,A., Kruger,R., Pham,V. V., Chobanyan-Jürgens,K., Wedekind,D., Arndt,T., Jörns,A., Berbee,J. F. P., Princen,H. M. G., Lücke,T., Mariotti,F., Huneau,J. F., Ückert,S., Frölich,J. C., Lenzen,S.,
Results, meta-analysis and a first evaluation of UNOxR, the urinary nitrate-to-nitrite molar ratio, as a measure of nitrite reabsorption in experimental and clinical settings
Amino Acids 2018; 50(7):799-821
Original publication
http://dx.doi.org/10.1007/s00726-018-2573-z
Wolling,H., Konze,S. A., Höfer,A., Erdmann,J., Pich,A., Zweigerdt,R., Buettner,F. F. R.,
Quantitative Secretomics Reveals Extrinsic Signals Involved in Human Pluripotent Stem Cell Cardiomyogenesis
Proteomics 2018; 18(14):e1800102-
Original publication
http://dx.doi.org/10.1002/pmic.201800102
Zhao,T., Li,R., Tan,X., Zhang,J., Fan,C., Zhao,Q., Deng,Y., Xu,A., Lukong,K. E., Genth,H., Xiang,J.,
Simulated Microgravity Reduces Focal Adhesions and Alters Cytoskeleton and Nuclear Positioning Leading to Enhanced Apoptosis via Suppressing FAK/RhoA-Mediated mTORC1/NF-kappaB and ERK1/2 Pathways
Int.J.Mol.Sci. 2018; 19(7):E1994-
Original publication
http://dx.doi.org/10.3390/ijms19071994
Buck A, Kayacelebi A A, Chobanyan-Jürgens K, Illsinger S, Bohnhorst B, Beckmann B, Hanff E, Das A M, Tsikas D, Lücke T
Comprehensive analysis of the L-arginine/L-homoarginine/nitric oxide pathway in preterm neonates: potential roles for homoarginine and asymmetric dimethylarginine in fetal growth.
Amino Acids 2017; 49(4):783-794
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Debez A, Belghith I, Pich A, Taamalli W, Abdelly C, Braun H P
High salinity impacts germination of the halophyte Cakile maritima but primes seeds for rapid germination upon stress release.
Physiol. Plant. 2017, ppl.12679-
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Erdmann J, Junemann J, Schröder A, Just I, Gerhard R, Pich A
Glucosyltransferase-dependent and -independent effects of TcdB on the proteome of HEp-2 cells.
Proteomics 2017; 17(15-16):1600435-
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Fischer V, Just I
Quality assurance in examinations using the example of 10 years of e-examinations at the MHH.
Quality in Science (QiW) 2017; 11(2):60-64
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Günes D N, Kayacelebi A A, Hanff E, Lundgren J, Redfors B, Tsikas D
Metabolism and distribution of pharmacological homoarginine in plasma and main organs of the anesthetized rat.
Amino Acids 2017; 49(12):2033-2044
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Haghikia A, Yanchev G R, Kayacelebi A A, Hanff E, Bledau N, Widera C, Sonnenschein K, Haghikia A, Weissenborn K, Bauersachs J, Bavendiek U, Tsikas D
The role of L-arginine/L-homoarginine/nitric oxide pathway for aortic distensibility and intima-media thickness in stroke patients.
Amino Acids 2017; 49(6):1111-1121
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Hoepfner J, Kleinsorge M, Papp O, Alfken S, Heiringhoff R, Pich A, Sauer V, Zibert A, Göhring G, Schmidt H, Sgodda M, Cantz T
In vitro modeling of familial amyloidotic polyneuropathy allows quantitative detection of transthyretin amyloid fibril-like structures in hepatic derivatives of patient-specific induced pluripotent stem cells.
Biol.Chem. 2017; 398(8):939-954
Original publication
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Junemann J, Lämmerhirt C M, Polten F, Just I, Gerhard R, Genth H, Pich A
Quantification of small GTPase glucosylation by clostridial glucosylating toxins using multiplexed MRM analysis.
Proteomics 2017; 17(9):1700016-
Original publication
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Kayacelebi A A, Minovic I, Hanff E, Frenay A S, de Borst M H, Feelisch M, van Goor H, Bakker S J L, Tsikas D
Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients.
Amino Acids 2017; 49(7):1193-1202
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Konze S A, Cajic S, Oberbeck A, Hennig R, Pich A, Rapp E, Buettner F F R
Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells.
Chembiochem 2017; 18(13):1317-1331
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Konze S A, Werneburg S, Oberbeck A, Olmer R, Kempf H, Jara-Avaca M, Pich A, Zweigerdt R, Buettner F F
Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms.
J. Proteome Res. 2017; 16(3):1133-1149
Original publication
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Kukoc-Modun L, Tsikas D, Kraljevi T, Biocic M, Radi N
Kinetic Spectrophotometric Determination of N-Acetyl-L-cysteine Ethyl Ester (NACET) Generating Chromogenic Copper(I)Ln Complexes with Different Ligands.
Croat. Chem. Acta 2017; 90(2):263-271
Original publication
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Lam K H, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R
The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein.
Toxicon 2017; DOI: 10.1016/j.toxicon.2017.10.012-
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Nkuipou-Kenfack E, Schanstra J P, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands J L, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber T B, Rudolph K L, Pich A, Mischak H, Zürbig P
The use of urinary proteomics in the assessment of suitability of mouse models for ageing.
PLoS One 2017; 12(2):e0166875-
Original publication
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Peck M W, Smith T J, Anniballi F, Austin J W, Bano L, Bradshaw M, Cuervo P, Cheng L W, Derman Y, Dorner B G, Fisher A, Hill K K, Kalb S R, Korkeala H, Lindström M, Lista F, Luquez C, Mazuet C, Pirazzini M, Popoff M R, Rossetto O, Rummel A, Sesardic D, Singh B R, Stringer S C
Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature.
Toxins (Basel) 2017; 9(1):DOI: 10.3390/toxins9010038-
Overview
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Reboll M R, Korf-Klingebiel M, Klede S, Polten F, Brinkmann E, Reimann I, Schonfeld H J, Bobadilla M, Faix J, Kensah G, Gruh I, Klintschar M, Gaestel M, Niessen H W, Pich A, Bauersachs J, Gogos J A, Wang Y, Wollert K C
EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction.
Circulation 2017; 136(19):1809-1823
Original publication
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Rohrbeck A, Höltje M, Adolf A, Oms E, Hagemann S, Ahnert-Hilger G, Just I
The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif.
J. Biol. Chem. 2017; 292(43):17668-17680
Original publication
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Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, Gerhard R, Alekov A
Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB.
Front. Cell. Infect. Microbiol. 2017; 7(67-
Original publication
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Rummel A
Two Feet on the Membrane: Uptake of Clostridial Neurotoxins.
Curr.Top.Microbiol.Immunol. 2016; DOI: 10.1007/82_2016_48-
Overview
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Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, Lenarz T, Warnecke A
Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics.
PLoS One 2017; 12(5):e0178182-
Original publication
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Tsikas D
Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first.
Atherosclerosis 2017; 264:79-82
Editorial
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Tsikas D
The dilemma of oxidative stress personified by the disprosopus 8-iso-prostaglandin F2a and prostaglandin F2a.
J Controversies Biomed Res 2017; 3(1):11-15
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Tsikas D
Does oxidative stress change during orthotopic liver transplantation?
J Controversies Biomed Res 2017; 3(2):1-5
Original publication
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Tsikas D
Does the Inhibitory Action of Asymmetric Dimethylarginine (ADMA) on the Endothelial Nitric Oxide Synthase Activity Explain Its Importance in the Cardiovascular System? The ADMA Paradox.
J Controversies Biomed Res 2017; 3(1):16-22
Original publication
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Tsikas D
Letter to the Editor regarding "Identification of the oleic acid ethanolamide (OEA) isomer cis-vaccenic acid ethanolamide (VEA) as a highly abundant 18:1 fatty acid ethanolamide in blood plasma from rats and humans".
Anal.Bioanal Chem. 2017; 409(9):2495-
Letter
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Tsikas D
Measuring NO production rate from l-arginine in MELAS by mass spectrometry-based approaches: GC-MS or LC-MS/MS?
Int.J.Cardiol. 2017; DOI: 10.1016/j.ijcard.2017.11.040-
Letter
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Tsikas D
Peroxynitrite-mediated 9,10-dihydroxylation of deuterium-labeled oleic acid in human hemolysate to threo- and erythro-dihydroxy-[9,10-2H2]stearic acid.
JSM Biochem Mol Biol 2017; 4(2):1027-
Original publication
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Tsikas D
What we-authors, reviewers and editors of scientific work-can learn from the analytical history of biological 3-nitrotyrosine.
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1058:68-72
Overview
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Tsikas D, Böhmer A
S-Transnitrosation reactions of hydrogen sulfide (H2S/HS-/S2-) with S-nitrosated cysteinyl thiols in phosphate buffer of pH 7.4: Results and review of the literature.
Nitric Oxide 2017; 65:22-36
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Tsikas D, Bollenbach A, Savvidou M D
Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction?
Amino Acids 2017; DOI: 10.1007/s00726-017-2522-2-
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Tsikas D, Eigendorf J
Diet and Exercise and Serum Markers of Oxidative Stress-Letter.
Cancer.Prev.Res.(Phila) 2017; 10(8):485-486
Letter
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Tsikas D, Hanff E
Lacking linearity in quantitative stable-isotope LC-MS/MS measurement of F2-isoprostanes is an irrefutable indicator of analytical inadequacy.
J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1064:139-142
Overview
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Tsikas D, Hanff E, Becker T
Drastic decrease of global l-arginine bioavailability during orthotopic liver transplantation: A matter of ATP deficiency of the graft?
Nitric Oxide 2017;73: 96-97; DOI: 10.1016/j.niox.2017.02.009-
Letter
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Tsikas D, Hanff E, Bollenbach A
S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-adenosyl-L-methionine's chemistry, physiology and pharmacokinetics.
World J Gastroenterol. 2017; 23(40):7343-7346
Letter
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Tsikas D, Hanff E, Brunner G
Helicobacter pylori, Its Urease and Carbonic Anhydrases, and Macrophage Nitric Oxide Synthase.
Trends Microbiol. 2017; 25(8):601-602
Letter
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Tsikas D, Hanff E, Brunner G
Spermidine for a long, dementia-free life?
Glob J Pharmaceu Sci 2017; 2(1):GJPPS.MS.ID.555576-
Overview
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Tsikas D, Kinzel M
Associations between asymmetric dimethylarginine (ADMA), nitrite-dependent renal carbonic anhydrase activity and plasma testosterone levels in hypogonadal men.
Hellenic J.Cardiol. 2017; DOI: 10.1016/j.hjc.2017.10.004-
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Tsikas D, Savvidou M
Plasma Oleic Acid Oxide in Women at Risk of Preeclampsia Correlates Inversely with Birthweight Centile.
JSM Biochem Mol Biol 2017; 4(2):1028-
Original publication
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Tsikas D, Schwedhelm K S, Surdacki A, Giustarini D, Rossi R, Kukoc-Modun L, Kedia G, Ückert S
S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET) � Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants:Results and overview.
2017; 8(1):1-9; DOI: 10.1016/j.jpha.2017.12.003-
Original publication
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by Elsner L, Hagemann S, Just I, Rohrbeck A
Anti-proliferative Effect of C3 Exoenzyme in Fibroblasts is Mediated by c-Jun Phosphorylation.
J Mol Signal 2017; 12(1-
Original publication
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Yao G, Lam K H, Perry K, Weisemann J, Rummel A, Jin R
Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H.
Toxins (Basel) 2017; 9(3):93; DOI:10.3390/toxins9030093-
Original publication
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Yao G, Lam K H, Weisemann J, Peng L, Krez N, Perry K, Shoemaker C B, Dong M, Rummel A, Jin R
A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding.
Sci. Rep. 2017; 7(1):7438-
Original publication
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Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M
Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission.
PLoS Pathog. 2017; 13(8):DOI: 10.1371/journal.ppat.1006567-
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Frädrich C, Beer LA, Gerhard R
Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B
Toxins (Basel) 2016; 8 (1), 25
Overview
Abstract
Böhmer A, Pich A, Schmidt M, Haghikia A, Tsikas D
Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells
Journal of Chromatography B. Analyt Technol.Biomed.Life.Sci. 2016; 1019 (72-82)
Original publication
Abstract
Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M
The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme
Journal of Neurochemistry 2016; 139 (2): 234-244
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Dong L, Helmke A, Waisman A, Haller H, Pich A, von Vietinghoff S
Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization
Scientific Reports 2016; 6 (36598-)
Original publication
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Dorner BG, Zeleny R, Harju K, Hennekinne JA, Vanninen P, Schimmel H, Rummel A
Biological toxins of potential bioterrorism risk: Current status of detection and identification technology
TrAC Trends in Analytical Chemistry 2016; 85 (Part B): 89-102
Overview
Abstract
Gerhard R
Receptors and Binding Structures for Clostridium difficile Toxins A and B
Current Topics in Microbiology and Immunology 2016: 1-18
Original publication
Abstract
Krueger J, Pohl S, Preusse M, Kordes A, Rugen N, Schniederjans M, Pich A, Häussler S
Unraveling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa
Environmental Microbiology 2016; 18 (10): 3583-3592
Original publication
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Mahrhold S, Bergström T, Stern D, Dorner BG, Astot C, Rummel A
Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1
Biochemical Journal 2016; 473 (17): 2645-2654
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Rohrbeck A, Fühner V, Schröder A, Hagemann S, Vu XK, Berndt S, Hust M, Pich A, Just I
Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody
Toxins (Basel) 2016; 8(4):100
Original publication
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Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M
Frizzled proteins are colonic epithelial receptors for C. difficile toxin B
Nature 2016; 538(7625): 350-355
Original publication
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von Elsner L, Hagemann S, Just I, Rohrbeck A
C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors
Naunyn Schmiedeberg's Archives of Pharmacology 2016; 389 (9): 1021-1031
Original publication
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Weisemann J, Stern D, Mahrhold S, Dorner BG, Rummel A
Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin
Toxins (Basel) 2016; 8(5), 154
Original publication
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Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R
N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A
Nature Structural & Molecular Biology 2016; 23 (7): 656-662
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Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF
Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS
Proc.Natl.Acad.Sci.U.S.A. 2016; 113 (8): E1034-E1043
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Junemann J, Birgin G, Erdmann J, Schröder A, Just I, Gerhard R, Pich A
Toxin A of the nosocomial pathogen Clostridium difficile induces primary effects in the proteome of HEp-2 cells
Germany : WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Proteomics Clinical Applications 2016; 11 (3-4)
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Genth H, Schelle I, Just I
Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
Toxins (Basel) 2016; 8 (4): 109
Original publication
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Hansbauer EM, Skiba M, Endermann T, Weisemann J, Stern D, Dorner MB, Finkenwirth F, Wolf J, Luginbühl W, Messelhäußer U, Bellanger L, Woudstra C, Rummel A, Fach P, Dorner BG
Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry
Analyst 2016; 141 (18): 5281 -5297
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Kutschenko A, Reinert MC, Krez N, Liebetanz D, Rummel A
BoNT/AB hybrid maintains similar duration of paresis as BoNT/A wild-type in murine running wheel assay
Netherlands : Elsevier B.V, NeuroToxicology 2016; 59: 1-8
Original publication
Abstract
Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D
Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells
Denmark : John Wiley & Sons A/S. Published by John Wiley & Sons Ltd, Experimental Dermatology 2017; 26 (1): 44-50
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Schelle I, Bruening J, Buetepage M, Genth H
Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
Toxins (Basel) 2016; 9 (1), 2
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Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T, Niessen HW, Mizrahi J, Schönfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC
Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction
Nature medicine 2015;2;2;140-149
Kull S, Schulz KM, Strotmeier JW, Kirchner S, Schreiber T, Bollenbach A, Dabrowski PW, Nitsche A, Kalb SR, Dorner MB, Barr JR, Rummel A, Dorner BG
Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype
PLoS One 2015;10;2
Rohrbeck A, von Elsner L, Hagemann S, Just I
Uptake of Clostridium botulinum C3 exoenzyme into Intact HT22 and J774A.1 Cells
Toxins 2015;7;380-395
Bothe M, Dutow P, Pich A, Genth H, Klos A
DXD motif-dependent and -independent effects of the Chlamydia trachomatis cytotoxin CT166
Toxins 2015;17;621-637
Hashemi Nassab M, Rhein M, Hagemeier L, Kaeser M, Muschler M, Glahn A, Pich A, Heberlein A, Kornhuber J, Bleich S, Frieling H, Hillemacher T
Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients.
Eur Addict Res 2016;22(2);59 -69
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Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R
Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics.
Toxicon 2015;107(Pt.A);43 -49
Abstract
Reichert O, Kolbe L, Terstegen L, Staeb F, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G
UV radiation induces CXCL5 expression in human skin.
Exp Dermatol 2015;24(4);309 -312
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Rummel A
The long journey of botulinum neurotoxins into the synapse.
Toxicon 2015;107(Pt.A):9 -24
Abstract
Rohrbeck A, Stahl F, Höltje M, Hettwer T, Lindner P, Hagemann S, Pich A, Haastert-Talini K
C3-induced release of neurotrophic factors from Schwann cells - potential mechanism behind its regeneration promoting activity
Neurochem Int 2015; 90;232 -245
Abstract
Schröder A, Rohrbeck A, Just I, Pich A
Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme.
J Proteome Res 2015;14(11);4721 -4733
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Emmrich S, Engeland F, El-Khatib M, Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink M, Klusmann JH
miR-139-5p controls translation in myeloid leukemia through EIF4G2.
Oncogene 2015;DOI: 10.1038/onc.2015.247
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Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H
Identification of ageing-associated naturally occurring peptides in human urine. Oncotarget 2015;6(33);34106 -34117
Abstract
Saul VV, Niedenthal R, Pich A, Weber F, Schmitz ML
SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity.
Biochim Biophys Acta 2015;1853(1);136 -143
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Weldearegay YB, Pich A, Schieck E, Liljander A, Gicheru N, Wesonga H, Thiaucourt,F, Kiirika LM, Valentin-Weigand P, Jore J, Meens J
Proteomic characterization of pleural effusion, a specific host niche of Mycoplasma mycoides subsp. mycoides from cattle with contagious bovine pleuropneumonia (CBPP).
J Proteomics 2015. DOI: 10.1016/j.jprot.2015.10.016
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Keller B, Mühlenkamp M, Deuschle E, Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jimenez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E
Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells.
Cell Microbiol 2015;17(8);1179 -1204
Full text
Dorner BG, Rummel A
Preface biological Toxins ancient molecules posing a current threat.
Toxins 2015;7(12);5320 -5321
Full text
Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F.
Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca and GTPgammaS ,,Toxicology,2015;328():48-56
Originalpublication
Chatterji,B. ; Dickhut,C. ; Mielke,S. ; Krüger,J. ; Just,I. ; Glage,S. ; Meier,M. ; Wedekind,D. ; Pich,A.
MALDI imaging mass spectrometry to investigate endogenous peptides in an animal model of Usher's disease ,
Germany,Proteomics,2014;14(13-14):1674-1687
Originalpublication
Dressler,D. ; Adib Saberi,F. ; Bigalke,H.
IncobotulinumtoxinA (Xeomin((R))) can produce antibody-induced therapy failure in a patient pretreated with abobotulinumtoxinA (Dysport((R)))
Austria,J.Neural Transm.,2014;121(7):769-771
Case report
Dressler,D. ; Gessler,F. ; Tacik,P. ; Bigalke,H.
An enzyme-linked immunosorbent assay for detection of botulinum toxin-antibodies
United States,Mov.Disord.,2014;29(10):1322-1324
Original publication
Genth,H. ; Pauillac,S. ; Schelle,I. ; Bouvet,P. ; Bouchier,C. ; Varela-Chavez,C. ; Just,I. ; Popoff,M. R.
Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins
England,Cell.Microbiol.,2014;16(11):1706-1721
Original publication
Gonzalez-Escalona,N. ; Thirunavukkarasu,N. ; Singh,A. ; Toro,M. ; Brown,E. W. ; Zink,D. ; Rummel,A. ; Sharma,S. K.
Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type
United States,Genome Announc,2014;2(6):10.1128/genomeA.01275-14
Original publication
Goy,S. D. ; Olling,A. ; Neumann,D. ; Pich,A. ; Gerhard,R.
Human neutrophils are activated by a peptide fragment of Clostridium difficile Toxin B presumably via formyl peptide receptor ,,Cell.Microbiol.,2015;17(6):893-909
Original publication
Hardtke-Wolenski,M. ; Taubert,R. ; Noyan,F. ; Sievers,M. ; Dywicki,J. ; Schlue,J. ; Falk,C. S. ; Lundgren,B. A. ; Scott,H. S. ; Pich,A. ; Anderson,M. S. ; Manns,M. P. ; Jaeckel,E.
Autoimmune hepatitis in a murine APS-1 model is directed against multiple autoantigens ,,Hepatology,2015;61(4):1295-1305
Original publication
Jochim,N. ; Gerhard,R. ; Just,I. ; Pich,A.
Time-resolved cellular effects induced by TcdA from Clostridium difficile
England,Rapid Commun.Mass Spectrom.,2014;28(10):1089-1100
Original publication
Jünger,J. ; Just,I.
Recommendations of the German Society for Medical Education and the German Association of Medical Faculties regarding university-specific assessments during the study of human, dental and veterinary medicine
Germany,GMS Z.Med.Ausbild,2014;31(3):Doc34-
Original publication
Konze,S. A. ; van Diepen,L. ; Schröder,A. ; Olmer,R. ; Moller,H. ; Pich,A. ; Weissmann,R. ; Kuss,A. W. ; Zweigerdt,R. ; Buettner,F. F.
Cleavage of E-cadherin and beta-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells
United States,Mol.Cell.Proteomics,2014;13(4):990-1007
Original publication
Lee,K. ; Lam,K. H. ; Kruel,A. M. ; Perry,K. ; Rummel,A. ; Jin,R.
High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex
United States,Biochem.Biophys.Res.Commun.,2014;446(2):568-573
Original publication
Lee,K. ; Zhong,X. ; Gu,S. ; Kruel,A. M. ; Dorner,M. B. ; Perry,K. ; Rummel,A. ; Dong,M. ; Jin,R.
Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex
United States,Science,2014;344(6190):1405-1410
Original publication
Matsui,T. ; Gu,S. ; Lam,K. H. ; Carter,L. G. ; Rummel,A. ; Mathews,I. I. ; Jin,R.
Structural Basis of the pH-Dependent Assembly of a Botulinum Neurotoxin Complex
England,J.Mol.Biol.,2014;426(22):3773-3782
Originalpublication
May,M. ; Schelle,I. ; Brakebusch,C. ; Rottner,K. ; Genth,H.
Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry
United States,Cell.Cycle,2014;13(14):2211-2221
Original publication
Nkuipou-Kenfack,E. ; Koeck,T. ; Mischak,H. ; Pich,A. ; Schanstra,J. P. ; Zürbig,P. ; Schumacher,B.
Proteome analysis in the assessment of ageing ,,Ageing Res.Rev.,2014;18C():74-85
Overview
Olling,A. ; Hüls,C. ; Goy,S. ; Müller,M. ; Krooss,S. ; Rudolf,I. ; Tatge,H. ; Gerhard,R.
The combined repetitive oligopeptides of clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation
Switzerland,Toxins (Basel),2014;6(7):2162-2176
Original publication
Rohrbeck,A. ; Schröder,A. ; Hagemann,S. ; Pich,A. ; Höltje,M. ; Ahnert-Hilger,G. ; Just,I.
Vimentin mediates uptake of C3 exoenzyme
United States,PLoS One,2014;9(6):e101071-
Original publication
Rohrbeck,A. ; von Elsner,L. ; Hagemann,S. ; Just,I.
Binding of Clostridium botulinum C3 exoenzyme to intact cells
Germany,Naunyn Schmiedebergs Arch.Pharmacol.,2014;387(6):523-532
Original publication
Rummel,A. ;
The dual receptor recognition of botulinum neurotoxins
New York, NY,,2014;4():129-150
Book contribution, monograph
Saul,V. V. ; Niedenthal,R. ; Pich,A. ; Weber,F. ; Lienhard Schmitz,M.
SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity
Netherlands,Biochim.Biophys.Acta,2015;1853(1):136-143
Original publication
Strotmeier,J. ; Mahrhold,S. ; Krez,N. ; Janzen,C. ; Lou,J. ; Marks,J. D. ; Binz,T. ; Rummel,A.
Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A
Netherlands,FEBS Lett.,2014;588(7):1087-1093
Original publication
Wagner,S. ; Maibaum,D. ; Pich,A. ; Nolte,I. ; Murua Escobar,H.
Verification of a Canine PSMA (FolH1) Antibody
Greece,Anticancer Res.,2015;35(1):145-148
Original publication
Wohlan,K. ; Goy,S. ; Olling,A. ; Srivaratharajan,S. ; Tatge,H. ; Genth,H. ; Gerhard,R.
Pyknotic cell death induced by Clostridium difficile TcdB: Chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity ,,Cell.Microbiol.,2014;76(11):1678-1692
Originalpublication
Boetzkes,Alexander
Secretome analysis of hypervirulent Clostridium difficile strains ,,,2014;():Getr. count-
Dissertation
Brandes,Vanessa
Phosphorylation of Rac1/Cdc42 mediated by tauroursodeoxycholic acid causes reduced glucosylation catalyzed by C. difficile toxin B ,,,2014;():Bl. 77 - 84, Bl. 11 - 43-
Dissertation
Goy,Sebastian David
Clostridium difficile Toxin B activates formyl peptide receptor 1 of human neutrophil granulocytes via N-terminal glucosyltransferase domain ,,,2014;():138 Bl. Ill., graph. Illustrations -
Dissertation
Rotsch,Jacqueline
Cellular effects of the bacterial exoenzyme C3 bot ,,,2011;():III, 72 Bl. Ill., graph. Fig.-
Dissertation
Beer,Lara-Antonia
The role of the low molecular weight GTpase Rac1 and the NADPH oxidase in Clostridium difficile TcdB-induced pyknosis ,,,2011;():-
Master thesis
Petersen,Lara
The role of Rho-GTPases in the cytopathic and cytotoxic effects of Clostridium difficile toxins ,,,2011;():62 p.-
Master thesis
Gangl,Anna-Katharina
Effects of the marine toxin latrunculin B on the epithelial barrier function of the colon ,,,2011;():37 p.-
Bachelor thesis
Bagramyan,K. ; Kaplan,B. E. ; Cheng,L. W. ; Strotmeier,J. ; Rummel,A. ; Kalkum,M.
Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples
United States,Anal.Chem.,2013;85(11):5569-5576
Original publication
Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F.
Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialyzed with high free-Ca(2+) and GTPgammaS containing intracellular solution
Netherlands,Eur.J.Pharmacol.,2013;720(1-3):227-236
Original publication
Barth,H. ; Bigalke,H. ; Gerhard,R. ;
Bacterial Toxins (Ch. 42)
Stuttgart,,2013;():1157-1180
Book contribution, monograph
Bigalke,H.
Botulinum toxin: application, safety, and limitations
Germany,Curr.Top.Microbiol.Immunol.,2013;364():307-317
Original publication
Chatterji,B. ; Pich,A.
MALDI imaging mass spectrometry and analysis of endogenous peptides
England,Expert Rev.Proteomics,2013;10(4):381-388
Original publication
Gerhard,R. ; Frenzel,E. ; Goy,S. ; Olling,A.
Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain ,,J.Med.Microbiol.,2013;62(9):1414-1422
Original publication
Höltje,M. ; Schulze,S. ; Strotmeier,J. ; Mahrhold,S. ; Richter,K. ; Binz,T. ; Bigalke,H. ; Ahnert-Hilger,G. ; Rummel,A.
Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons ,,Toxicon,2013;75C():108-121
Original publication
Huelsenbeck,S. C. ; Roggenkamp,D. ; May,M. ; Huelsenbeck,J. ; Brakebusch,C. ; Rottner,K. ; Ladwein,M. ; Just,I. ; Fritz,G. ; Schmidt,G. ; Genth,H.
Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1
Netherlands,Int.J.Biochem.Cell Biol.,2013;45(8):1767-1775
Original publication
Lee,K. ; Gu,S. ; Jin,L. ; Le,T. T. ; Cheng,L. W. ; Strotmeier,J. ; Kruel,A. M. ; Yao,G. ; Perry,K. ; Rummel,A. ; Jin,R.
Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity
United States,PLoS Pathog.,2013;9(10):e1003690-
Original publication
Mahrhold,S. ; Strotmeier,J. ; Garcia-Rodriguez,C. ; Lou,J. ; Marks,J. D. ; Rummel,A. ; Binz,T.
Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E
England,Biochem.J.,2013;453(1):37-47
Original publication
May,M. ; Wang,T. ; Müller,M. ; Genth,H.
Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470
Switzerland,Toxins (Basel),2013;5(1):106-119
Original publication
Pirazzini,M. ; Henke,T. ; Rossetto,O. ; Mahrhold,S. ; Krez,N. ; Rummel,A. ; Montecucco,C. ; Binz,T.
Neutralization of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain
Netherlands,FEBS Lett.,2013;587(23):3831-3836
Original publication
Rangrez,A. Y. ; Bernt,A. ; Poyanmehr,R. ; Harazin,V. ; Boomgaarden,I. ; Kuhn,C. ; Rohrbeck,A. ; Frank,D. ; Frey,N.
Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy
United States,J.Cell Biol.,2013;203(4):643-656
Original publication
Rummel,A.
Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity
Germany,Curr.Top.Microbiol.Immunol.,2013;364():61-90
Original publication
Scherr,M. ; Elder,A. ; Battmer,K. ; Barzan,D. ; Bomken,S. ; Ricke-Hoch,M. ; Schröder,A. ; Venturini,L. ; Blair,H. J. ; Vormoor,J. ; Ottmann,O. ; Ganser,A. ; Pich,A. ; Hilfiker-Kleiner,D. ; Heidenreich,O. ; Eder,M. ;
Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL positive B-lineage acute lymphoblastic leukemia ,,Leukemia,2014;28(3):554-565
Original publication
Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P.
The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases
United States,PLoS Pathog.,2013;9(11):e1003746-
Original publication
Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P.
The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases
United States,PLoS Pathog.,2013;9(11):e1003746-
Original publication
Steffen,A. ; Ladwein,M. ; Dimchev,G. A. ; Hein,A. ; Schwenkmezger,L. ; Arens,S. ; Ladwein,K. I. ; Holleboom,J. M. ; Schur,F. ; Small,J. V. ; Schwarz,J. ; Gerhard,R. ; Faix,J. ; Stradal,T. E. ; Brakebusch,C. ; Rottner,K.
Rac function is critical for cell migration but not required for spreading and focal adhesion formation ,,J.Cell.Sci.,2013;126(Pt.20):4572-4588
Originalpublication
Stevens,G. B. ; Silver,D. A. ; Zgaga-Griesz,A. ; Bessler,W. G. ; Vashist,S. K. ; Patel,P. ; Achazi,K. ; Strotmeier,J. ; Worbs,S. ; Dorner,M. B. ; Dorner,B. G. ; Pauly,D. ; Rummel,A. ; Urban,G. A. ; Krueger,M.
Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity ,,Analyst,2013;138(20):6154-6162
Original publication
Willjes,G. ; Mahrhold,S. ; Strotmeier,J. ; Eichner,T. ; Rummel,A. ; Binz,T.
Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity
United States,Biochemistry,2013;52(22):3930-3938
Original publication
Zeiser,J. ; Gerhard,R. ; Just,I. ; Pich,A.
Substrate Specificity of Clostridial Glucosylating Toxins and Their Function on Colonocytes Analyzed by Proteomics Techniques ,,J.Proteome Res.,2013;12(4):1604-1618
Originalpublication
Völker,Anne Katrin
Identification and characterization of the receptor binding pockets of botulinum neurotoxin serotype D (BoNTD) ,,,2013;():Getr. count Ill., graph. Illustrations -
Dissertation
Benski,Anastasia ;
Analysis of C3bot exoenzyme-dependent ADP-ribosylation of smal Rho-GTPases by Mass Spectrometry ,,,2013;():-
Master thesis
Hüls,Corinna
Intracellular association of functional domains of Clostridium difficile toxin A ,,,2013;():-
Master thesis
Raasch,Sabine
Inhibition of clostridial glucosylating toxins by tauro- and glucoconjugated bile acids ,,,2013;():-
Master thesis
Ulfig,Anneli
Investigation of endogenous peptides in rat brain using MALDI Imaging and LC-MS ,,,2013;():-
Master thesis
Völkening,Lea
Neutralizing effect of tauro- and glycoconjugated bile acids on Clostridium difficile toxin B ,,,2013;():-
Master thesis
Wohlan,Katharina
Rho-dependent and independent effect of Clostridium difficile toxin B on the cell cycle ,,,2013;():-
Master thesis
Bollenbach,Alexander
Identification of the activity-reducing amino acids of botulinum neurotoxin subtypes A4 and A8 (Chemnitz strain) ,,,2012;():-
Bachelor thesis
Weigt,David
The effect of cytotoxic necrotizing factors from Yersinia pseudotuberculosis and Escherichia coli on the epithelial barrier function of cultured renal epithelial cells ,,,2012;():-
Bachelor thesis
Auer M, Schweigreiter R, Hausott B, Thongrong S, Höltje M, Just I, Bandtlow C, Klimaschewski L.
Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons.
Front Cell Neurosci 2012;6;43
Original publication
Baron,J. ; Blex,C. ; Rohrbeck,A. ; Rachakonda,S. K. ; Birnbaumer,L. ; Ahnert-Hilger,G. ; Brunk,I.
The alpha-subunit of the trimeric GTPase Go2 regulates axonal growth ,,J.Neurochem.,2013;124(6):782-794
Original publication
Bigalke H, Frevert J.
Botulinum toxin A: dose and immune response.
Int J Rehabil Res 2012;35(2);93
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Boetzkes,A. ; Felkel,K. W. ; Zeiser,J. ; Jochim,N. ; Just,I. ; Pich,A.
Secretome analysis of Clostridium difficile strains
Germany,Arch.Microbiol.,2012;194(8):675-687
Original publication
Brandes V, Schelle I, Brinkmann S, Schulz F, Schwarz J, Gerhard R, Genth H.
Protection from C. difficile Toxin B-catalyzed Rac/Cdc42 glucosylation by tauroursodeioxycholic acid-induced Rac/Cdc42 phosphorylation.
Biol Chem 2012;1;393(1-2);77-84
Original publication
Chiaradia,E. ; Avellini,L. ; Tartaglia,M. ; Gaiti,A. ; Just,I. ; Scoppetta,F. ; Czentnar,Z. ; Pich,A.
Proteomic evaluation of sheep serum proteins
England,BMC Vet.Res.,2012;8():66-
Original publication
Debez,A. ; Braun,H. P. ; Pich,A. ; Taamalli,W. ; Koyro,H. W. ; Abdelly,C. ; Huchzermeyer,B.
Proteomic and physiological responses of the halophyte Cakile maritima to moderate salinity at the germinative and vegetative stages
Netherlands,J.Proteomics,2012;75(18):5667-5694
Original publication
Gu,S. ; Rumpel,S. ; Zhou,J. ; Strotmeier,J. ; Bigalke,H. ; Perry,K. ; Shoemaker,C. B. ; Rummel,A. ; Jin,R.
Botulinum neurotoxin is shielded by NTNHA in an interlocked complex
United States,Science,2012;335(6071):977-981
Original publication
Hammerschmidt,A. ; Chatterji,B. ; Zeiser,J. ; Schröder,A. ; Genieser,H. G. ; Pich,A. ; Kaever,V. ; Schwede,F. ; Wolter,S. ; Seifert,R.
Binding of Regulatory Subunits of Cyclic AMP-Dependent Protein Kinase to Cyclic CMP Agarose
United States,PLoS One,2012;7(7):e39848-
Original publication
Hefter,H. ; Hartmann,C. ; Kahlen,U. ; Moll,M. ; Bigalke,H.
Prospective analysis of neutralising antibody titres in secondary non-responders under continuous treatment with a botulinumtoxin type A preparation free of complexing proteins--a single cohort 4-year follow-up study
England,BMJ Open,2012;2(4):10.1136/bmjopen-2011-000646. Print 2012
Original publication
Huelsenbeck,J. ; May,M. ; Schulz,F. ; Schelle,I. ; Ronkina,N. ; Hohenegger,M. ; Fritz,G. ; Just,I. ; Gerhard,R. ; Genth,H.
Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin
Netherlands,FEBS Lett.,2012;586(20):3665-3673
Original publication
Hülsenbeck SC, Rohrbeck A, Handreck A, Hellmich G, Kiaei E, Roettinger I, Grothe C, Just I, Haastert-Tallini K.
C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury
Neurotherapeutics 2012;9;185-198
Original publication
Katsch,K. ; de Jong,S. J. ; Albrecht,J. C. ; Steger,J. ; Genth,H. ; Posern,G. ; Biesinger,B.
Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip
England,Cell.Commun.Signal.,2012;10(1):5-811X-10-5
Original publication
May,M. ; Kolbe,T. ; Wang,T. ; Schmidt,G. ; Genth,H.
Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis
United States,J.Signal.Transduct,2012;2012():570183-
Original publication
Olling A, Seehase S, Minton NP, Tatge H, Schröter S, Kohlscheen S, Pich A, Just I, Gerhard R.
Release of TcdA and TcdB from Clostridium cdi 630 is not affected by functional inactivation of the tcdE gene.
Microb Pathog 2012;52(1);92-100
Original publication
Rohrbeck,A. ; Kolbe,T. ; Hagemann,S. ; Genth,H. ; Just,I.
Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q
England,FEBS J.,2012;279(15):2657-2671
Original publication
Rotsch J, Rohrbeck A, May M, Kolbe T, Hagemann S, Schelle I, Just I, Genth H, Huelsenbeck SC.
Inhibition of macrophage migration by C. botulinum exoenzyme C3
Naumyn-Schmiedebergs's Arch Pharmacol 2012;385(9);883-90. May29 [Epub ahead of print]
Original publication
Schwarz,J. ; Proff,J. ; Hävemeier,A. ; Ladwein,M. ; Rottner,K. ; Barlag,B. ; Pich,A. ; Tatge,H. ; Just,I. ; Gerhard,R.
Serine-71 phosphorylation of rac1 modulates downstream signaling
United States,PLoS One,2012;7(9):e44358-
Original publication
Strotmeier,J. ; Willjes,G. ; Binz,T. ; Rummel,A.
Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity
Netherlands,FEBS Lett.,2012;586(4):310-313
Original publication
Weigoldt,M. ; Meens,J. ; Bange,F. C. ; Pich,A. ; Gerlach,G. F. ; Goethe,R.
Metabolic adaptation of Mycobacterium avium subsp. paratuberculosis to the gut environment ,,Microbiology,2013;159(Pt.2):380-391
Original publication
Wellhöner,H. ; Weiss,A. ; Schulz,A. ; Adermann,K. ; Braitbard,O. ; Bar-Sinai,A. ; Hochman,J.
Reversing ABCB1-mediated multi-drug resistance from within cells using translocating immune conjugates
England,J.Drug Target.,2012;20(5):445-452
Original publication
Euler,Friederike Christina
Significance of autoproteolysis for the intracellular effect of Clostridium difficile toxin A ,,,2011;():50 Bl.-
Dissertation
Fritsch,Cornelia
Binding and uptake of Clostridium botulinum C3 exoenzyme in F98 cells ,,,2012;():97 Bl.-
Dissertation
Janzen,Constantin
Identification of the SV2 binding pocket in the H CC domain of botulinum neurotoxin serotype A ,,,2012;():[2], 73 Bl.-
Dissertation
Lica,Marta Anna
Differences in the biological effect of Clostridium difficile toxin B in proliferating and non-proliferating cells ,,,2011;():[1], 275-283, 10-25 Bl.-
Dissertation
Roggenkamp,Dennis
Functional characterization of the interaction of skin cells and neuronal cells in healthy and stressed skin ,,,2011;():VI p., p. 7-94, IV p.-
Dissertation
Schröder,Anke
Effects of the C3 exoenzyme from Clostridium botulinum on the proteome of murine hippocampal cells ,,,2012;():VI, 107 p. Ill., graph. Fig.-
Dissertation
Zeiser,Johannes
The substrate spectrum of clostridial glucosylating toxins and the effects on the proteome of colonocytes ,,,2012;():[7], 3 - 106, [20] Bl.-
Dissertation
Brinkmann,Sophie
Cdk 1 dependent phosphorylation of the Rac GEF protein beta-Pix ,,,2012;():-
Master thesis
Doberenz,Sebastian ;
Kinetic analysis of toxin A-mediated glucosylation of small GTPases ,,,2012;():-
Master thesis
Edeling,Maria
Functional characterization of renal tubular cells in a model for diabetic nephropathy ,,,2012;():-
Master thesis
Findeisen,Katja
Neutralization of Clostridium difficile toxin B by tauro-conjugated bile acids ,,,2012;():-
Master thesis
Krüger,Jonas
Ribosomal proteome analysis of C3 exoenzyme-treated cells ,,,2012;():-
Master thesis
Nolte,Annika
The Rac1-induced upregulation of Frizzled receptors ,,,2012;():-
Master thesis
Rataj,Dennis
Involvement of CIC-5 in the cellular uptake of the clostridial toxins TcdA and TcdA1-1874 ,,,2012;():-
Master thesis
Boer U, Lohrenz A, Klingenberg M, Pich A, Haverich A, Wilhelmi M.
The effect of detergent-based decellularization procedures on cellular proteins and immunogenicity in equine carotid artery grafts.
Biomaterials 2011;32;9730-9737
Original publication
Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, Schulz TF, Jacobs R, Messerle M, Kay-Federov PC.
The Human Cytomegalovirus UL11 Protein Interacts with the Receptor Tyrosine Phosphatase CD45, Resulting in Functional Paralysis of T Cells.PLoS Pathog 2011;7(12)
Original publication
Gerhard R, Queißer S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I.
Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B
Naunyn Schmiedebergs Arch Pharmacol 2011;383;285-295
Original publication
Höltje M, Just I, Ahnert-Hilger G.
Clostridial C3 proteins: Recent approaches to improve neuronal growth and regeneration.
Ann Anat 2011;193(4);314-320
Original publication
Jochim N, Gerhard R, Just I, Pich A.
Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotype-coded protein labeling and LC-MALDI.
Proteome Sci 2011;9;48
Original publication
Lica M, Schulz F, Schelle I, May M, Just I, Genth H.
Difference in the biological effects of Clostridium difficile B in profilerating and non-proliferating cells.
Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);275-283
Original publication
Mueller MQ, Zeiser JJ, Dreiocker F, Pich A, Schaefer M, Sinz A.
An universal matrix-assisted laser desorption/ionization cleavable cross-linker for protein structure analysis.
Rapid Commun Mass Spectrom 2011;25(1);155-161
Original publication
Nölle A, Zeug A, van Bergeijk, Tönges L, Gerhard R, Brinkmann H, Al Rayes S, Hensel N, Schill Y, Apkhazava D, Jablonka S, Omer J, Srivastrav RK, Baasner A, Lingor P, Wirth B, Ponimaskin E, Niedenthal R, Grothe C, Claus P.
The Spinal Muscular Atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin.
Human molecular genetics 2011;15;20(24);4865-4878
Original publication
Olling A, Goy S, Hoffmann F, Tatge H, Just I, Gerhard R.
The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A.
PLoS One 2011;18;6(3) e17623
Original publication
Oumeraci T, Schmidt B, Wolf T, Zapatka M, Pich A, Brors B, Eils R, Fleischhacker M, Schlegelberger B, v. Neuhoff N.
Bronchoalveolar lavage fluid of lung cancer patients: mapping the uncharted waters using proteomics technology.
Lung Cancer 2011;72(1);136-138
Original publication
Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grünwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gönczy P, Malek NP.
The SCF-Fbxw5 E3-ubiquitin ligase is regulated by Plk4 and targets HsSAS-6 to control centrosome duplication.
Nat Cell Biol 2011;13(8);1004-1009
Original publication
Rost BR, Nicholson P, Ahnert-Hilger G, Rummel A, Rosenmund C, Breustedt J, Schmitz D.
Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion.
J Cell Science 2011;15;124(Pt18);3066-73
Original publication
Rummel A, Mahrhold S, Bigalke H, Binz T.
Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin.
FEBS J 2011;278(23);4506-4515
Original publication
Rummel,A.
Molecular biology of Clostridium botulinum organism and botulinum neurotoxins, insight into the molecular machinery involved in Clostridium botulinum neurotoxity ,Hauppauge, N.Y.,,2011;():37-70
Book contribution, monograph
Rummel,A. ; Mahrhold,S. ; Bigalke,H. ; Binz,T.
Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin ,,FEBS J.,2011;278(23):4506-4515 10.1111/j.1742-4658.2011.08196.x
Original publication
Schacht T, Unger C, Pich A, Wydra K.
Endo- and exopolygalacturonases of Ralstonia solanacearum are inhibited by polygalacturonase-inhibiting protein (PGIP) activity in tomato stem extracts.
Plant Physiol Biochem 2011;49(4);377-387
Original publication
Schulte-Baukloh H, Herholz J, Bigalke H, Miller K, Knispel HH.
Results of a BoNT/A Antibody Study in Children and Adolescents after Onabotulinumtoxin A (Botox(R)) Detrusor Injection.
Urol Int 2011;87(4);434-438
Original publication
Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T.
The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites.
Mol Microbiol 2011;81(1);143-156
Original publication
Wolf T, Oumeraci T, Gottlieb J, Pich A, Brors B, Eils R, Haverich A, Schlegelberger B, Welte T, Zapatka M, von Neuhoff N.
Proteomic Bronchiolitis Obliterans Syndrome Risk Monitoring in Lung Transplant Recipients.
Transplantation 2011;92(4);477-485
Original publication
Zeiser J, Klodmann J, Braun HP, Gerhard R, Just I, Pich A.
Effects of Clostridium difficile Toxin A on the proteome of colonocytes studied by differential 2D electrophoresis.
Journal of Proteomics 2011;75;469-479
Original publication
Felkel,Katharina-Wiebke
LC-MS based secretome analysis of different Clostridium difficile strains ,,,2010;():104 Bl.-
Dissertation
Halabi Cabezon,Ismael
Abrogation of the cytopathic effect of Clostridium difficile toxin B by Rac1 activation ,,,2010;():3751-3756, 7-20 Bl.-
Dissertation
Jochim,Nelli
LC-MS-based global proteome analysis of colon cells after treatment with clostridial glucosylating toxins ,,,2011;():XVII, 124 Bl.-
Dissertation
Kreimeyer,Isa
The autoproteolytic cleavage influences the cytotoxic effect of Clostridium difficile toxin A ,,,2010;():36 Bl.-
Dissertation
Lücke,Nina
Secretome analysis of the hematopoietic progenitor cell line DKmix ,,,2010;():46 Bl.-
Dissertation
May,Martin
Role of Rac1 and PAK in the regulation of G2-M transition and mitotic cell rounding ,,,2011;():[7], 79 Bl.-
Dissertation
Schrader,Merle
Correlation of C. difficile toxin A-induced apoptosis with the upregulation of the GTP-binding protein RhoB ,,,2011;():62 Bl.-
Dissertation
Werner,Stefan
Characterization of the cellular uptake of C. botulinum C3 exoenzyme ,,,2010;():[3], 86 Bl.-
Dissertation
Dickhut,Clarissa
Imaging mass spectrometry for the histological analysis of tissues ,,,2010;():-
Master thesis
Frenzel,Eileen
Characterization of the cellular uptake of the C. difficile toxins TcdA and TcdA1-1874 ,,,2010;():-
Master thesis
Lentes,Jana
Effects of GTP loading on the glucosylation of Rho proteins by Clostridia toxins ,,,2011;():-
Bachelor thesis
Adler,S. ; Bicker,G. ; Bigalke,H. ; Bishop,C. ; Blumel,J. ; Dressler,D. ; Fitzgerald,J. ; Gessler,F. ; Heuschen,H. ; Kegel,B. ; Luch,A. ; Milne,C. ; Pickett,A. ; Ratsch,H. ; Ruhdel,I. ; Sesardic,D. ; Stephens,M. ; Stiens,G. ; Thornton,P. D. ; Thürmer,R. ; Vey,M. ; Spielmann,H. ; Grune,B. ; Liebsch,M.
The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting
England,Altern.Lab.Anim.,2010;38(4):315-330
Original publication
Backert S, Kenny B, Gerhard R, Tegtmeyer N, Bran S.
PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463: A novel pathway in regulating Rac1 GTPase function.
Gut Microbes 2010;1(2);94-99
Original publication
Dahal,D. ; Pich,A. ; Braun,H. P. ; Wydra,K.
Analysis of cell wall proteins regulated in stem of susceptible and resistant tomato species after inoculation with Ralstonia solanacearum: a proteomic approach
Netherlands,Plant Mol.Biol.,2010;73(6):643-658
10.1007/s11103-010-9646-z
Original publication
Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, Bigalke H, Suckling J, Ushkaryov Y, Naumenko N, Shakirzyanova A, Giniatullin R, Maywood E, Hastings M, Binz T, Davletov B.
SNARE tagging allows stepwise assembly of a multimodular medicinal toxin.
Proc Natl Acad Sci USA 2010;107(42);18197-18201
Original publication
Genth H, Just I.
Functional implications of lethal toxin-catalyzed glucosylation of (H/K/N)Ras and Rac1 in Clostridium sordellii-associated disease.
Eur J Cell Biol 2010;12(4);Epub ahead of print
Original publication
Genth H, Schulz F, Just I.
Gluscosylation of Rho/Ras Proteins by Lethal Toxin - Implication of Actin Re-Organization and Apoptosis in C. Sordellii-Associated Disease.
Open Toxinology 2010;3;13-18
Original publication
Just I, Hülsenbeck SC, Genth H.
Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and a Neurotrophic Agent.
Open Toxinology 2010;3;19-23
Original publication
Just I, Rohrbeck A, Huelsenbeck SC, Hoeltje M.
Therapeutic effects of Clostridium botulinum C3 exoenzyme.
Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);247-52; Epub 2010
Review
Kreimeyer I, Euler F, Marckscheffel A, Tatge H, Pich A, Olling A, Schwarz J, Just I, Gerhard R.
Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A.
Naunyn Schmiedebergs Arch Pharmacol 2010;11(3); Epub 2010
Original publication
Krückeberg J, Just I, Möbs D, Matthies H, Fischer V.
Added value recognized, deficits eliminated? - Quantitative analysis of electronically written exams at Hannover Medical School.
GMA [ed:] Annual conference of the Society for Medical Education (GMA). Bochum, 23-25.09.2010
Lecture
Luecke N, Templin C, Muetzelburg MV, Neumann D, Just I, Pich A.
Secreted proteome of the murine multipotent hematopoietic progenitor cell line DKmix.
Rapid Commun Mass Spectrom 2010;24(5);561-570
Original publication
Naue N, Fedorov R, Pich A, Manstein DJ, Curth U.
Site-directed mutagenesis of the {chi} subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction.
Nucleic Acids Res 2010;23(10); Epub ahead of print
Original publication
Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R.
Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner.
Biochem J 2010;431(2):207-216
Original publication
Thalmann J, Janik K, May M, Sommer K, Ebeling J, Hofmann F, Genth H, Klos A.
Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac.
PLoS One 2010;5(3)
Original publication
Häfner,Kirstin
Competition experiments on the mouse hemidiaphragm assay for the identification of protein receptors of clostridial neurotoxins: SV2 mediates the uptake of BoNT/F into neuronal cells ,,,2010;():-
Dissertation
Lange,Oliver
Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A : much ado about nothing? ,,,2010;():213 - 218, 16 Bl.-
Dissertation
Nottrott,Stefanie
Clostridium difficile toxin A-induced apoptosis is independent of p53 but dependent on glucosylation of Rho-GTPases ,,,2010;():[1], 33 Bl.-
Dissertation
Supthut,Hauke
Intra- and extracellular factors determining the sensitivity of CHO cells to Clostridium difficile toxin B ,,,2009;():89 Bl.-
Dissertation
Barlag,Britta
Involvement of IQGAP and MRCK in phospho-Rac1-mediated filopodia formation ,,,2010;():-
Master thesis
Goy,Sebastian
Significance of the receptor binding domain of Clostridium difficile toxin A for functionality ,,,2010;():-
Master thesis
Kolbe,Tanja
Effect of Rho-modified bacterial toxins in an in vitro model of wound healing ,,,2010;():-
Diploma thesis
Wang,Tianbang
F-actin depolymerization by clostridial toxins ,,,2010;():-
Diploma thesis
Andresen,H. ; Bingel,U. ; Streichert,T. ; Schmoldt,A. ; Zoerner,A. A. ; Tsikas,D. ; Just,I.
Severe glycerol intoxication after Meniere's disease diagnosis--case report and overview of kinetic data
England,Clin.Toxicol.(Phila),2009;47(4):312-316
10.1080/15563650902849123
Original publication
Binz,T. ; Rummel,A.
Cell entry strategy of clostridial neurotoxins
England,J.Neurochem.,2009;109(6):1584-1595
10.1111/j.1471-4159.2009.06093.x
Original publication
Brunger,A. T. ; Rummel,A.
Receptor and substrate interactions of clostridial neurotoxins
England,Toxicon,2009;54(5):550-560
10.1016/j.toxicon.2008.12.027
Original publication
Deplazes,J. ; Fuchs,M. ; Rauser,S. ; Genth,H. ; Lengyel,E. ; Busch,R. ; Luber,B. ;
Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation
England,Hum.Mol.Genet.,2009;18(19):3632-3644
10.1093/hmg/ddp312
Original publication
Dreger,S. C. ; Schulz,F. ; Huelsenbeck,J. ; Gerhard,R. ; Hofmann,F. ; Just,I. ; Genth,H.
Killing of Rat Basophilic Leukemia Cells by Lethal Toxin from Clostridium sordellii: Critical Role of Phosphatidylinositide 3'-OH Kinase/Akt Signaling (dagger) ,,Biochemistry,2009;():-
10.1021/bi800708b
Original publication
Genth H, Schulz F, Just I.
Glucosylation of Rho/Ras Proteins by Lethal Toxin - Implications of Actin-Re-Organization and Apoptosis in C. Sordellii-Associated Disease.
The Open Toxinology Journal 2009;2
Abstract
Huelsenbeck,S. C. ; Klose,I. ; Reichenbach,M. ; Huelsenbeck,J. ; Genth,H.
Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalyzed by Clostridium sordellii lethal toxin
Netherlands,FEBS Lett.,2009;583(19):3133-3139
10.1016/j.febslet.2009.09.006
Original publication
Huelsenbeck,S. C. ; May,M. ; Schmidt,G. ; Genth,H.
Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors--reinforcing the critical role of RhoA in cytokinesis
United States,Cell Motil.Cytoskeleton,2009;66(11):967-975
10.1002/cm.20390
Original publication
Just I, Hülsenbeck SC, Genth H.
Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and an Neurothrophic Agent.
The Open Toxinology Journal 2009;2
Abstract
Kotz,A. ; Wagener,J. ; Engel,J. ; Routier,F. ; Echtenacher,B. ; Pich,A. ; Rohde,M. ; Hoffmann,P. ; Heesemann,J. ; Ebel,F.
The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity ,,Fungal Genet.Biol.,2010;47(2):169-178
10.1016/j.fgb.2009.10.001
Original publication
Lange,O. ; Bigalke,H. ; Dengler,R. ; Wegner,F. ; deGroot,M. ; Wohlfarth,K.
Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A: much ado about nothing?
United States,Clin.Neuropharmacol.,2009;32(4):213-218
10.1097/WNF.0b013e3181914d0a
Originalpublikation
Mohammadi,B. ; Buhr,N. ; Bigalke,H. ; Krampfl,K. ; Dengler,R. ; Kollewe,K.
A long-term follow-up of botulinum toxin A in cervical dystonia ,,Neurol.Res.,2009;31(5):463-466
10.1179/174313209X405137
Original publication
Mohammadi,B. ; Kollewe,K. ; Wegener,M. ; Bigalke,H. ; Dengler,R.
Experience with long-term treatment with albumin-supplemented botulinum toxin type A
Austria,J.Neural Transm.,2009;116(4):437-441
10.1007/s00702-009-0200-6
Original publication
Nerlich,A. ; Rohde,M. ; Talay,S. R. ; Genth,H. ; Just,I. ; Chhatwal,G. S.
Invasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a phosphatidylinositol 3-kinase-independent mechanism
United States,J.Biol.Chem.,2009;284(30):20319-20328
10.1074/jbc.M109.016501
Original publication
Rummel,A. ; Häfner,K. ; Mahrhold,S. ; Darashchonak,N. ; Holt,M. ; Jahn,R. ; Beermann,S. ; Karnath,T. ; Bigalke,H. ; Binz,T.
Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilizing the three isoforms of SV2 as second receptor
England,J.Neurochem.,2009;110(6):1942-1954
10.1111/j.1471-4159.2009.06298.x
Original publication
Schoentaube,J. ; Olling,A. ; Tatge,H. ; Just,I. ; Gerhard,R.
Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A ,,Cell.Microbiol.,2009;11(12):1816-1826
10.1111/j.1462-5822.2009.01373.x
Original publication
Schulz,F. ; Just,I. ; Genth,H.
Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid
United States,Biochemistry,2009;48(38):9002-9010
10.1021/bi900964c
Original publication
Sun,X. ; He,X. ; Tzipori,S. ; Gerhard,R. ; Feng,H.
Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages
England,Microb.Pathog.,2009;46(6):298-305
10.1016/j.micpath.2009.03.002
Original publication
von Witzendorff,D. ; Maass,K. ; Pich,A. ; Ebeling,S. ; Kölle,S. ; Kochel,C. ; Ekhlasi-Hundrieser,M. ; Geyer,H. ; Geyer,R. ; Töpfer-Petersen,E.
Characterization of the acidic N-linked glycans of the zona pellucida of prepuberal pigs by a mass spectrometric approach
Netherlands,Carbohydr.Res.,2009;344(12):1541-1549
10.1016/j.carres.2009.05.002
Originalpublication
Goltz,Björn
Tetanus toxin and botulinum toxin A : Interaction with mast cells from the rat peritoneal cavity ,,,2008;():IV, 140 p.-
Dissertation
Teichert,Matthias
Characterization of mutated Clostridium difficile toxin A for the determination of glucosyltransferase-dependent effects ,,,2007;():11 p.-
Dissertation
Busche,S. ; Descot,A. ; Julien,S. ; Genth,H. ; Posern,G.
Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signaling
England,J.Cell.Sci.,2008;121(Pt 7):1025-1035
10.1242/jcs.014456
Original publication
Genth,H. ; Dreger,S. C. ; Huelsenbeck,J. ; Just,I.
Clostridium difficile toxins: More than mere inhibitors of Rho proteins
England,Int.J.Biochem.Cell Biol.,2008;40(4):592-597
10.1016/j.biocel.2007.12.014
Original publication
Gerhard,R. ; Nottrott,S. ; Schoentaube,J. ; Tatge,H. ; Olling,A. ; Just,I.
Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells
England,J.Med.Microbiol.,2008;57(Pt 6):765-770
10.1099/jmm.0.47769-0
Original publication
Halabi-Cabezon,I. ; Huelsenbeck,J. ; May,M. ; Ladwein,M. ; Rottner,K. ; Just,I. ; Genth,H.
Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1
Netherlands,FEBS Lett.,2008;582(27):3751-3756
10.1016/j.febslet.2008.10.003
Original publication
Hoffmann,A. ; Hofmann,F. ; Just,I. ; Lehnardt,S. ; Hanisch,U. K. ; Brück,W. ; Kettenmann,H. ; Ahnert-Hilger,G. ; Höltje,M.
Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia
United States,Glia,2008;56(11):1162-1175
10.1002/glia.20687
Original publication
Höltje,M. ; Djalali,S. ; Hofmann,F. ; Münster-Wandowski,A. ; Hendrix,S. ; Boato,F. ; Dreger,S. C. ; Grosse,G. ; Henneberger,C. ; Grantyn,R. ; Just,I. ; Ahnert-Hilger,G.
A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation ,,FASEB J.,2009;23(4):1115-1126/10.1096/fj.08-116855
Original publication
Höltje,M. ; Hofmann,F. ; Lux,R. ; Veh,R. W. ; Just,I. ; Ahnert-Hilger,G.
Glutamate uptake and release by astrocytes are enhanced by Clostridium botulinum C3 protein
United States,J.Biol.Chem.,2008;283(14):9289-9299
10.1074/jbc.M706499200
Original publication
Kamanova,J. ; Kofronova,O. ; Masin,J. ; Genth,H. ; Vojtova,J. ; Linhartova,I. ; Benada,O. ; Just,I. ; Sebo,P.
Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling
United States,J.Immunol.,2008;181(8):5587-5597
Original publication
Klisch,K. ; Jeanrond,E. ; Pang,P. C. ; Pich,A. ; Schuler,G. ; Dantzer,V. ; Kowalewski,M. P. ; Dell,A.
A tetraantennary glycan with bisecting N-acetylglucosamine and the Sd(a) antigen is the predominant N-glycan on bovine pregnancy-associated glycoproteins
England,Glycobiology,2008;18(1):42-52
10.1093/glycob/cwm113
Original publication
Kühnel,T. S. ; Schulte-Mattler,W. ; Bigalke,H. ; Wohlfarth,K.
Treatment of habitual snoring with botulinum toxin: a pilot study ,,Sleep Breath,2008;12(1):63-68
10.1007/s11325-007-0136-8
Original publication
Muetzelburg,M. V. ; Hofmann,F. ; Just,I. ; Pich,A.
Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis ,,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2009;877(13):1344-1351
10.1016/j.jchromb.2008.12.005
Original publication
Neumann,D. ; Kollewe,C. ; Pich,A. ; Cao,P. ; Resch,K. ; Martin,M. U.
Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation
United States,J.Leukoc.Biol.,2008;84(3):807-813
10.1189/jlb.0507290
Original publication
Sander,L. E. ; Frank,S. P. ; Bolat,S. ; Blank,U. ; Galli,T. ; Bigalke,H. ; Bischoff,S. C. ; Lorentz,A.
Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells
Germany,Eur.J.Immunol.,2008;38(3):855-863
10.1002/eji.200737634
Original publication
Schulte-Baukloh,H. ; Bigalke,H. ; Miller,K. ; Heine,G. ; Pape,D. ; Lehmann,J. ; Knispel,H. H.
Botulinum neurotoxin type A in urology: antibodies as a cause of therapy failure
Australia,Int.J.Urol.,2008;15(5):407-15; discussion 415
10.1111/j.1442-2042.2008.02016.x
Original publication
Stolz,A. ; Haines,N. ; Pich,A. ; Irvine,K. D. ; Hokke,C. H. ; Deelder,A. M. ; Gerardy-Schahn,R. ; Wuhrer,M. ; Bakker,H.
Distinct contributions of beta4GalNAcTA and beta4GalNAcTB to Drosophila glycosphingolipid biosynthesis
United States,Glycoconj.J.,2008;25(2):167-175
10.1007/s10719-007-9069-5
Original publication
Tschernig,T. ; Neumann,D. ; Pich,A. ; Dorsch,M. ; Pabst,R.
Experimental bronchial asthma - the strength of the species rat
Netherlands,Curr.Drug Targets,2008;9(6):466-469
Original publication
Conrad S, Genth H, Hofmann F, Just I, Skutella T.
Neogenin-RGMa signaling at the growth cone Is BMP-independent and involves RhoA, rock and PKC.
J Biol Chem 2007;282(22);16423-33
Abstract
Fessler MB, Arndt PG, Just I, Nick JA, Malcolm KC, Worthen GS.
Dual role for RhoA in suppression and induction of cytokines in the human neutrophil.
Blood 2007;109(3);1248-1256
Abstract
Frommberger M, Zürbig P, Jantos J, Krahn T, Mischak H, Pich A, Just I,Schmitt-Kopplin P, Schiffer E.
Peptidomic analysis of rat urine using capillary electrophoresis coupled to mass spectrometry.
Proteomics 2007;1(7);650-60
Abstract
Huelsenbeck J, Dreger S, Gerhard R, Barth H, Just I, Genth H.
Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470.
Inf Immun 2007;75(2);801-809
Abstract
Huelsenbeck J, Dreger S, Gerhard R, Fritz G, Just I, Genth H.
Up-regulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile.
Biochemistry 2007;24;46(16);4923-31
Abstract
Jin R, Sikorra S, Stegmann CM, Pich A, Binz T, Brunger AT.
Neurotoxin serotype C1 light chain protease: implications for dual substrate specificity.
Biochemistry 2007;46;10685-93
Abstract
Klisch K, Jeanrond E, Pang PC, Pich A, Schuller G, Dantzer V, Kowalewski MP, Dell A.
A tetraantennary glycan with bisecting N-acetylglucosamine and Sda antigen is the predominant N-glycan on bovine Pregnancy-associated glycoproteins.
Glycobiology 2008;18(1);42-52; Epub 2007
Abstract
Meyer GK, Neetz A, Brandes G, Tsikas D, Butterfield JH, Just I, Gerhard R.
Clostridium difficile Toxin A and B directly stimulate human mast cells.
Inf Immun 2007;21(5)
Abstract
Nottrott S, Schoentaube J, Genth H, Just I, Gerhard R.
Apoptosis induced by Clostridium difficile Toxin A is p53-independent and triggered by glucosylation of Rho GTPases.
Apoptosis 2007;12(8);1443-53
Abstract
Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A, Mahrhold S, Sandhoff K, Proia RL, Acharya KR, Bigalke H, Binz T.
Identification of the receptor binding site of botulinum neurotoxins B and G proves the double receptor concept.
PNAS 2007;104;359-364
Abstract
Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M, Bakker H.
Distinct contributions of β4GalNAcTA and β4GalNAcTB to Drosophila glycospingolipid biosynthesis.
Glycoconj J 2008;25(2);167-75; Epub 2007
Abstract
Foster K, Bigalke H, Aoki R.
Botulinum Neurotoxin - From Laboratory to Bedside
Neurotoxicity Research 2006;9;133-140
Abstract
Genth H, Huelsenbeck J, Hartmann B, Hofmann F, Just I, Gerhard R.
Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B.
FEBS Lett 2006;580;3565-3569
Abstract
Giesemann T, Jank T, Gerhard R, Maier E, Just I, Benz R, Aktories K.
Cholesterol-dependent pore formation of Clostridium difficile toxin A.
J Biol Chem 2006;281;10808-10815
Abstract
Jin R, Rummel A, Binz T, Brunger AT.
Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity
Nature 2006;444;1092-1095
Abstract
Lee SH, Bigalke H.
Botulinum toxin - pharmacology, safety and secondary non-response by antibodies
Neuropediatrics in Clinical Department and Practice 2006;5;52-56
Overview
Mahrhold S, Rummel A, Bigalke H, Davletov B, Binz T.
The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves.
FEBS Lett 2006;Apr3;580(8);2011-4
Abstract
Molinari G, Rohde M, Wilde C, Just I, Aktories K, Chhatwal G.S.
Localization of the C3-like ADP-ribosyltransferase from Staphylococcus aureus during baterial invasion of mammalian cells.
Inf Immun 2006;74;3673-3677
Abstract
Rosales RL, Bigalke H, Dressler D.
Pharmacology of botulinum toxin: differences between type A preparations.
Eur J Neurol; 2006;13;2-10
Abstract
Schröder O, Gerhard R, Stein J.
Antibiotic-associated diarrhea
Diarrhea Z Gastroenterol 2006;44(2);193-204
Abstract
Stange DE, Radlwimmer B, Schubert F, Traub F, Pich A, Toedt G, Mendrzyk F, Lehmann U, Eils R, Kreipe H, Lichter, P.
High resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer.
Clin Cancer Res 2006;12;345-52
Abstract
Teichert M, Tatge H, Schoentaube J, Just I, Gerhard R.
Application of mutated Clostridium difficile toxin A for determination of glucosyltransferase-dependent effects.
Inf Immun 2006;74(10);6006-6010
Abstract
Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF.
Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis.
Lancet Oncol 2006;7(3);230-40
Abstract
Traub F, Jost M, Hess R, Schorn K, Menzel C, Budde P, Schulz-Knappe P, Lamping N, Pich A, Kreipe H, Tammen H.
Peptidomic analysis of breast cancer reveals a putative surrogate marker for estrogen receptor-negative carcinomas.
Lab Invest 2006;86;246-253
Abstract
Zürbig P, Renfrow MB, Schiffer E, Novak J, Walden M, Wittke S, Just I, Pelzig M, Neusüß C, Theodorescu D, Root KE, Ross MM, Mischak H.
Biomarker discovery by CE.MS enables sequences analysis via MS/MS with platform-independent separation.
Electrophoresis 2006;27(11);2111-21125
Abstract
Barth H, Pfeifer G, Hofmann F, Maier E, Benz R, Aktories K.
Low pH-induced formation of ion channels by Clostridium difficile toxin B in target cells.
J Biol Chem. 2001 Apr 6; 276(14): 10670-6.
Abstract
Bigalke H, Wohlfarth K, Irmer A, Dengler R.
Botulinum A toxin: Dysport improvement of biological availability.
Exp Neurol. 2001 Mar;168(1):162-70.
Abstract
Dreikhausen U, Varga G, Hofmann F, Barth H, Aktories K, Resch K, Szamel M.
Regulation by rho family GTPases of IL-1 receptor induced signaling: C3-like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL-2 gene expression.
Eur J Immunol. 2001 May; 31(5): 1610-9.
Abstract
Gülke I, Pfeifer G, Liese J, Fritz M, Hofmann F, Aktories K, Barth H.
Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile.
Infect Immun. 2001 Oct;69(10):6004-11.
Abstract
Just I, Hofmann F, Genth H, Gerhard R.
Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins.
Int J Med Microbiol. 2001 Sep;291(4):243-50.
Abstract
Klussmann E, Tamma G, Lorenz D, Wiesner B, Maric K, Hofmann F, Aktories K, Valenti G, Rosenthal W.
An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells.
J Biol Chem. 2001 Jun 8; 276(23): 20451-7.
Abstract
Rollnik JD, Wohlfarth K, Dengler R, Bigalke H.
Neutralizing botulinum toxin type a antibodies: clinical observations in patients with cervical dystonia.
Neurol Clin Neurophysiol. 2001;2001(3):2-4.
Abstract
Schnittler HJ, Schneider SW, Raifer H, Luo F, Dieterich P, Just I, Aktories K.
Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress.
Pflugers Arch. 2001 Aug;442(5):675-87.
Abstract
Walev I, Bhakdi SC, Hofmann F, Djonder N, Valeva A, Aktories K, Bhakdi S.
Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O.
Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3185-90.
Abstract
Wilde C, Chhatwal GS, Schmalzing G, Aktories K, Just I.
A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3.
J Biol Chem 2001 Mar 23;276(12):9537-42
Abstract
Yang SN, Yu J, Mayr GW, Hofmann F, Larsson O, Berggren PO.
Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase.
FASEB J. 2001 Aug;15(10):1753-63.
Abstract
Bigalke H.
Neuromuscular junction - presynaptic terminal.
Clin Neurophysiol 2000;31;115-121
Busch C, Hofmann F, Gerhard R, Aktories K.
Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases.
J Biol Chem. 2000 May 5;275(18):13228-34.
Abstract
Busch C, Schömig K, Hofmann F, Aktories K.
Characterization of the catalytic domain of Clostridium novyi alpha-toxin.
Infect Immun. 2000 Nov;68(11):6378-83.
Abstract
Dressler D, Bigalke H, Rothwell JC.
The sternocleidomastoid test: an in vivo assay to investigate botulinum toxin antibody formation in humans.
J Neurol. 2000 Aug;247(8):630-2.
Abstract
Dressler D, Dirnberger G, Bhatia KP, Irmer A, Quinn NP, Bigalke H, Marsden CD.
Botulinum toxin antibody testing: comparison between the mouse protection assay and the mouse lethality assay.
Mov Disord. 2000 Sep;15(5):973-6.
Abstract
Dressler D, Zettl U, Benecke R, Bigalke H.
Can intravenous immunoglobulin improve antibody-mediated botulinum toxin therapy failure?
Mov Disord. 2000 Nov;15(6):1279-81.
Abstract
Galmiche A, Rassow J, Doye A, Cagnol S, Chambard JC, Contamin S, de Thillot V, Just I, Ricci V, Solcia E, Van Obberghen E, Boquet P.
The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release.
EMBO J. 2000 Dec 1;19(23):6361-70.
Abstract
Genth H, Selzer J, Busch C, Dumbach J, Hofmann F, Aktories K, Just I.
New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization.
Infect Immun. 2000 Mar;68(3):1094-101.
Abstract
Just I, Boquet P
Large clostridial cytotoxins as tools in cell biology.
Curr Top Microbiol Immunol 2000;250;97-107
Review
Just I, Hofmann F, Aktories K
Molecular mode of action of the large clostridial cytotoxins.
Curr Top Microbiol Immunol 2000;250;55-83
Review
Lehnardt S, Ahnert-Hilger G, Bigalke H, Jöns T.
Acid secretion of parietal cells is paralleled by a redistribution of NSF and alpha, beta-SNAPs and inhibited by tetanus toxin
Histochem Cell Biol. 2000 Nov;114(5):387-91.
Abstract
Linseman DA, Hofmann F, Fisher SK.
A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinase.
J Neurochem. 2000 May;74(5):2010-20.
Abstract
Meyer DK, Olenik C, Hofmann F, Barth H, Leemhuis J, Brunig I, Aktories K, Nörenberg W.
Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1.
J Neurosci. 2000 Sep 15;20(18):6743-51.
Abstract
Procyk KJ, Rippo MR, Testi R, Hofmann F, Parker PJ, Baccarini M.
Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C.
Blood. 2000 Oct 1;96(7):2592-8.
Abstract
Rollnik JD, Matzke M, Wohlfarth K, Dengler R, Bigalke H.
Low-dose treatment of cervical dystonia, blepharospasm and facial hemispasm with albumin-diluted botulinum toxin type A under EMG guidance. An open label study.
Abstract
Vetter IR, Hofmann F, Wohlgemuth S, Herrmann C, Just I.
Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin.
J Mol Biol. 2000 Sep 1;301(5):1091-5.
Abstract
Wagner AH, Köhler T, Rückschloss U, Just I, Hecker M.
Improvement of nitric oxide-dependent vasodilation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation.
Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):61-9.
Abstract
Wilde C, Genth H, Aktories K, Just I.
Recognition of RhoA by Clostridium botulinum C3 exoenzyme.
J Biol Chem. 2000 Jun 2;275(22):16478-83.
Abstract
Feick P, Gilhaus S, Blum R, Hofmann F, Just I, Schulz I.
Inhibition of amylase secretion from differentiated AR4-2J pancreatic acinar cells by an actin cytoskeleton controlled protein tyrosine phosphatase activity.
FEBS Lett. 1999 May 28;451(3):269-74.
Abstract
Fritz G, Just I, Kaina B.
Rho GTPases are over-expressed in human tumors.
Int J Cancer. 1999 May 31;81(5):682-7.
Abstract
Genth H, Aktories K, Just I.
Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling.
J Biol Chem. 1999 Oct 8;274(41):29050-6.
Abstract
Jöns T, Lehnardt S, Bigalke H, Heim HK, Ahnert-Hilger G.
SNARE proteins and rab3A contribute to canalicular formation in parietal cells.
Eur J Cell Biol. 1999 Nov;78(11):779-86.
Abstract
Nörenberg W, Hofmann F, Illes P, Aktories K, Meyer DK.
Rundown of somatodendritic N-methyl-D-aspartate (NMDA) receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase RhoA.
Br J Pharmacol. 1999 Jul;127(5):1060-3.
Abstract
Adermann K, Raida M, Paul Y, Abu-Raya S, Bloch-Shilderman E, Lazarovici P, Hochman J, Wellhoner H.
Isolation, characterization and synthesis of a novel paradaxin isoform.
FEBS Lett. 1998 Sep 18;435(2-3):173-7.
Abstract
Barth H, Hofmann F, Olenik C, Just I, Aktories K.
The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin.
Infect Immun. 1998 Apr;66(4):1364-9.
Abstract
Barth H, Preiss JC, Hofmann F, Aktories K.
Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis.
J Biol Chem. 1998 Nov 6;273(45):29506-11.
Abstract
Ben-Ami G, Ozeri V, Hanski E, Hofmann F, Aktories K, Hahn KM, Bokoch GM, Rosenshine I.
Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli.
Infect Immun. 1998 Apr;66(4):1755-8.
Abstract
Boquet P, Munro P, Fiorentini C, Just I.
Toxins from anaerobic bacteria: speficity and molecular mechanism of action.
Curr Opinion Microbiol 1998;1;66-74
Abstract
Busch C, Hofmann F, Selzer J, Munro S, Jeckel D, Aktories K.
A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins.
J Biol Chem. 1998 Jul 31;273(31):19566-72.
Abstract
Gerhard R, Schmidt G, Hofmann F, Aktories K.
Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells.
Infect Immun. 1998 Nov;66(11):5125-31.
Abstract
Herrmann C, Ahmadian MR, Hofmann F, Just I.
Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35.
J Biol Chem. 1998 Jun 26;273(26):16134-9.
Abstract
Hofmann F, Busch C, Aktories K.
Chimeric clostridial cytotoxins: identification of the N-terminal region involved in protein substrate recognition.
Infect Immun. 1998 Mar;66(3):1076-81.
Abstract
Lucius C, Arner A, Steusloff A, Troschka M, Hofmann F, Aktories K, Pfitzer G.
Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins.
J Physiol. 1998 Jan 1;506 ( Pt 1):83-93.
Abstract
Naumann M, Toyka KV, Mansouri Taleghani B, Ahmadpour J, Reiners K, Bigalke H.
Depletion of neutralizing antibodies resensitizes a secondary non-responder to botulinum A neurotoxin.
J Neurol Neurosurg Psychiatry. 1998 Dec;65(6):924-7.
Abstract
Paul Y, Weiss A, Adermann K, Erdmann G, Kassebaum C, Lazarovici P, Hochman J, Wellhoner H.
Translocation of acylated pardaxin into cells.
FEBS Lett. 1998 Nov 27;440(1-2):131-4.
Abstract
Reiser CO, Lanz T, Hofmann F, Hofer G, Rupprecht HD, Goppelt-Struebe M.
Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins.
Biochem J. 1998 Mar 15;330 ( Pt 3):1107-14.
Abstract
Schmid G, Schürmann A, Huppertz C, Hofmann F, Aktories K, Joost HG.
Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin.
Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):385-92.
Abstract
Sehr P, Joseph G, Genth H, Just I, Pick E, Aktories K.
Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling.
Biochemistry. 1998 Apr 14;37(15):5296-304.
Abstract
Wohlfarth K, Goeschel H, Frevert J, Dengler R, Bigalke H.
Dose standardization of botulinum toxin: Reply.
Mov Disord. 1998, 13, 750-751.
Abstract
Goschel, H., Wohlfarth, K., Frevert, J., Dengler, R., Bigalke, H.
Botulinum A toxin therapy: neutralizing and nonneutralizing antibodies - therapeutic consequences.
Exp. Neurol. 147, 1997, 96-102.
Abstract
Hippenstiel, S., Tannert-Otto, S., Vollrath, N., Krüll, M., Just, I., Aktories, K., von Eichel-Streiber, C., Suttorp, N.
Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function.
Am. J. Physiol. 1997, 272, L38-L43.
Abstract
Hofmann, F., Busch, C., Prepens, U., Just, I., Aktories, K.
Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of holotoxin.
J. Biol. Chem. 1997, 272, 11074-11078.
Abstract
Olenik, C., Barth, H., Just, I., Aktories, K., Meyer, D.K.
Gene expression of the small GTP binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult brain.
Mol. Brain Res. 1997, 52, 272-279.
Abstract
Otto, B., Steusloff, A., Just, I., Aktories, K., Pfitzer, G.
Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea pig intestinal smooth muscle.
J. Physiol. (Lond.), 1997, 496, 317-329.
Abstract
Verschueren, H., de Baetselier, P., de Braekeleer, J., Dewitt, J., Aktories, K., Just, I.
ADP-ribosylation of Rho-proteins with botulinum C3 exoenzyme inhibits invasion and shape changes of T-lymphoma cells.
Eur. J. Cell Biol. 1997, 73, 182-187.
Abstract
Wohlfarth, K., Goschel, H., Frevert, J., Dengler, R., Bigalke, H.
Botulinum A toxins: units versus units.
Naunyn Schmiedeberg's Arch. Pharmacol. 1997, 355, 335-40.
Abstract