RNA‑Based Therapeutic Modulation of Post‑Myocardial‑Infarction Cardiac Remodeling Phase‑II, Multicenter, Randomized, Double‑Blind, Placebo‑Controlled Trial of the miR‑132 Antisense Oligonucleotide CDR132L May 2026 Acute myocardial infarction initiates a cascade of maladaptive remodeling processes that culminate in left ventricular systolic dysfunction and progressive heart failure. To compensate, pathological hypertrophic growth of cardiomyocytes is initiated, which further weakens the heart. More than ten years ago, we discovered that upregulation of a specific microRNA, namely miR-132, is associated with this pathological hypertrophy. We engineered a chemically modified antisense oligonucleotide, CDR132L, which selectively binds and silences miR‑132, thereby reversing chronic heart failure. The drug candidate CDR132L was now investigated in an international Phase 2 clinical trial in patients with recent myocardial infarction (MI) and left ventricular (LV) systolic dysfunction. The HF‑REVERT trial enrolled 294 patients (3–14 days post MI) across 80 study sites in seven European countries and the United Kingdom. Participants were randomized to receive standard heart‑failure therapy plus either CDR132L or placebo. “Our study demonstrated that CDR132L is safe and well-tolerated and does not cause harmful side effects on the liver, kidneys, hematopoietic system, or the heart“ says Prof. Thum. The drug was most effective in patients with already advanced cardiac remodeling, whose hearts were severely damaged. “This is an important step because, for the first time in a larger randomized trial, we could test whether a targeted intervention in pathological RNA‑driven remodeling after myocardial infarction yields a measurable benefit,” says the Director of the MHH Clinic for Cardiology and Angiology, Prof. Dr. Johann Bauersachs, first author and principal investigator of the study. “It is especially encouraging that the strongest signals were seen in patients whose hearts were already markedly remodeled and weakened. This group remains at high risk for chronic heart failure despite modern standard therapy.” These observations support further clinical development of the drug, particularly for chronic heart failure. The findings represent a major step toward RNA-based therapies in cardiology and offer great promise for positively influencing disease progression in patients with heart failure. CDR132L was developed by Cardior Pharmaceuticals GmbH, a spin‑off founded in 2016 by Prof. Dr. Dr. Thomas Thum based on his work at the Institute for Molecular and Translational Therapy Strategies. The spin‑off underscores the importance of university‑driven innovation for new therapeutic approaches. Currently, two additional clinical trials are ongoing in patients with chronic heart failure, led by the Danish pharmaceutical company Novo Nordisk, which acquired Cardior in 2024. Read the full publication here: https://www.nature.com/articles/s41591-026-04408-4 New Insights into Heart Failure Progression and Therapeutic Targets May 2026 Our recent publication sheds light on the molecular mechanisms driving heart failure (HF), offering potential avenues for prevention. Using plasma microRNA profiling from 799 elderly patients in the HOMAGE study, we identified specific miRNAs associated with HF onset. Machine learning analysis pinpointed miR-21-5p, miR-24-3p and miR-221-3p as the most informative miRNAs for HF prediction, while bioinformatic assessments revealed critical pathways associated with the incidence of HF: calcium homeostasis and signaling, cell proliferation and angiogenesis, stress response and remodeling, metabolic dysregulation, and neurohormonal activation. Notably, we highlighted existing FDA-approved drugs that could interact with these targets. These findings support the development of novel strategies for HF prevention and therapeutic intervention. Read the full publication here: https://www.sciencedirect.com/science/article/pii/S0953620526000294?via%3Dihub#sec0010 Three inspiring days at the iPSZürich Symposium! April 2026 Dr. Elisa Mohr , Ayse Boese , and Shirin Dildebekova enjoyed an exciting and productive meeting at the iPSZürich Symposium, a vibrant forum that brings together researchers working in the field of induced pluripotent stem cells (iPSCs) to share discoveries, exchange ideas, and foster new collaborations. The symposium showcased the latest advances in iPSC-based disease modeling, regenerative medicine, and translational research, highlighting the growing impact of stem cell technologies across biomedical disciplines. Over the course of three days, participants engaged in stimulating scientific discussions and gained valuable insights into emerging methodologies and applications of iPSC research. Ayse Boese and Dr. Elisa Mohr had the opportunity to present their recent work on cardiotoxic effects and multicellular human cardiac organoids in oral presentations, while PhD candidate Shirin Dildebekova proudly discussed her research in her first poster presentation. All three IMTTS members were supported by travel grants, and we would like to extend our sincere gratitude to the organizers for their generous support and for hosting such an inspiring and well-organized meeting. This recognition highlights the excellent work being carried out at IMTTS and made the symposium an especially memorable experience for the entire team. A special congratulations goes to Dr. Elisa Mohr , who was honored with the Best Oral Presentation Award for her outstanding scientific contribution. The importance of alternatives to animal testing and recent advances in NAMs March 2026 New approach methodologies (NAMs) gain more relevance in pre-clinical research refining human relevant in vitro platforms and consequently reducing animal testing. Over two days (March 17-18), experts of the field came together at the R2N symposium - Advancing Micro-Physiological Systems: Innovations and Applications in Biomedical Research here at the beautiful Hannover Medical School. In a lively discussion, Dr. Elisa Mohr presented her work on human multicellular cardiac organoids during an oral presentation. While PhD student Wilson Agyapong showed highlights of his projects about living myocardial slices in a wonderful poster presentation. Strong Performance at ADAC Marathon Hannover April 2026 The IMTTS once again attended the “ADAC Hannover Marathon Staffellauf”. Accompanied by great weather conditions and a fantastic atmosphere on the course, the IMTTS team demonstrated exceptional teamwork and endurance, finishing well under the 4-hour mark. Annual Meeting of the society of toxicology in the beautiful San Diego March 2026 The annual meeting of the Society of Toxicology (SOT) in San Diego is one of the world’s leading conferences in toxicology, attracting more than 5,000 participants and featuring around 1,900 poster presentations. Under sunny Californian skies, attendees engaged in four days of intensive discussions on the latest developments in toxicological research, including innovative, alternative testing strategies to reduce animal experimentation, environmental toxicology, carcinogenicity assessment, inhalation toxicology, and cardiotoxicity. Dr. Elisa Mohr attended the toxicology conference and presented her research in a poster session, engaging with an international audience of experts. The travel to the SOT was supported by the Gesellschaft der Freunde der MHH e.V . whose contribution made the participation in this important international scientific event possible. HBRS prize for the best poster presentation goes to Zeinab Mroue March 2026 IMTTS researcher Zeinab Mroue won the Best Poster Presentation award among second-year “Molecular Medicine” Ph.D. students at the HBRS annual retreat. Her winning poster, entitled “Modeling Immune Checkpoint Inhibitor–Induced Cardiotoxicity in Human Cardiac Cells,” highlights the growing significance of her research. By integrating in vitro cell culture, i n vivo mouse models and primary human material, her work comprehensively investigates the emerging field of ICI-induced cardiotoxicity. A new circRNA-based strategy shows promise for reducing inflammation and fibrosis after a myocardial infarction February 2026 IMTTS researchers have identified circHIPK2 as a critical regulator of pro-inflammatory macrophage activation and its downstream inflammatory cascade. Targeted inhibition of circHIPK2 in macrophages reduced inflammation and fibrosis in experimental models, improving heart function. These findings highlight circRNA-based macrophage modulation as a novel therapeutic strategy for treating cardiac dysfunction and other inflammatory diseases. Please find he original article here: https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehaf1116/8471743 Read more about the study here: https://www.mhh.de/en/presse/mhh-insight/startseite-news-detailed-view/molecular-switch-for-treatment-after-heart-attack-discovered Advancing Translational Heart Failure Research: IMTTS at the HFA Winter Meeting January 2026 IMTTS members Prof. Dr. Dr. Thomas Thum, Prof. Dr. Christian Bär, Dr. Malte Juchem, and Anita-Koula Pralas attended the Heart Failure Association (HFA) Winter Meeting on Translational Heart Failure Research in Berlin. They engaged in insightful discussions about the latest advances in heart failure research. Young Investigator Award for Dr. Malte Juchem January 2026 For his outstanding presentation on "Nucleoside-modified GLA mRNA rescues fabry cardiomyopathy phenotypes in human iPSC-derived cardiomyocytes", Dr. Malte Juchem received the Young Investigator Award – runner-up, endowed with 400€. IMTTS Christmas Party: Honoring Hard Work, Science, and Team Culture December 2025 The IMTTS Christmas Party was a wonderful opportunity to celebrate a year of hard work, excellent science, and strong teamwork. It brought together our team in a relaxed setting, reflecting our shared commitment to fostering a positive, supportive, and healthy work environment where people and ideas can thrive. We would like to thank Thomas for making this possible. From Organoids to Regeneration: The IMTTS at the CBFH Biennial Meeting 2025 November 2025 Our team was excited to take part in the CBFH Biennial Meeting , the joint meeting of the ESC Working Groups on Cellular Biology of the Heart and Myocardial Function , held from 26–28 November 2025 at the Centro Congressi Federico II in Naples, Italy . It was a great opportunity to share our latest research, connect with colleagues from around the world, and enjoy the vibrant scientific atmosphere. During the meeting, we presented several exciting projects. Prof. Dr. Christian Bär spoke about “Development of a multicellular heart organoid”, highlighting recent advances in organoid technology and heart modeling. Dr. Alessia Costa presented her work on “Telomerase as a key regulator of cardiomyocyte proliferation and heart regeneration” , sharing new insights into how telomerase reactivation can stimulate cardiomyocyte proliferation and improve cardiac regeneration. Giuseppe Cipriano introduced “An Ex vivo living myocardial slice model to study the early engraftment of human iPSC-derived cardiomyocytes”. Our team also actively contributed to the poster session. Ayse Boese presented her poster “ Functional characterization of circular non-coding RNAs in anthracycline-induced cardiotoxicity” .” exploring the role of circular non-coding RNAs in anthracycline-induced cardiotoxicity and their potential as therapeutic targets. Anita-Koula Pralas highlighted strategies to identify and target long non-coding RNAs involved in cardiac fibrosis, aiming to improve heart function in her poster “Identification and therapeutic targeting of long non-coding RNAs in cardiac fibrosis”. Overall, the meeting was an outstanding platform to present our research, strengthen international collaborations, and engage in inspiring scientific discussions. It was also a pleasure to experience the beautiful city of Naples. Professor Thum is a highly cited researcher for the sixth time November 2026 “Clarivate Analytics” has again identified the most cited researchers. Over the past decade, these scientists have produced multiple highly cited papers ranking in the top 1% of Web of Science™ citations by field and year. For the sixth time, IMTTS Director Professor Dr. Dr. Thomas Thum has been recognized as a highly cited researcher. He is listed in the category “Cross-Field”. The current list of Highly Cited Researchers ( https://clarivate.com/highly-cited-researchers/ ) includes 7,131 researchers from 23 disciplines in the natural, life and social sciences. Please see: https://www.mhh.de/en/presse/mhh-insight/startseite-news-detailed-view/mhh-researcher-highly-regarded Congratulations to Elisa Mohr on successfully defending his doctoral thesis November 2025 IMTTS scientist Elisa Mohr has successfully defended her PhD thesis entitled “Utilizing human cardiac organoids as a multicellular platform for cardiovascular disease modeling”. Advancing Great Science Together: The IMTTS Retreat November 2025 The IMTTS retreat was a fruitful day of focused work, inspiring discussions, and great science, strengthening collaboration across the team. Congratulations to Lea Oehlsen on the successful defense of her doctoral thesis November 2025 Lea Oehlsen was enrolled in the PhD program “Molecular Medicine” and has successfully defended her doctoral thesis entitled “Investigation of the long non-coding RNA Foxo6os in Cardiovascular Disease”. Transcriptional and functional effects of mavacamten in multiple porcine and human models with hypertrophic cardiomyopathy November 2025 In our recent study, we investigated how the myosin inhibitor mavacamten shapes cardiac function and gene expression across multiple porcine and human models of hypertrophic cardiomyopathy. While mavacamten consistently reduced contractile force, its effects on contraction dynamics and transcriptional pathways were highly model-specific, revealing broader impacts on cytoskeletal organization, stretch response, and metabolism. These findings suggest that mavacamten not only acts at the sarcomere but also drives distinct transcriptional remodeling depending on the cardiac model. Please find the original article here: https://doi.org/10.1111/bph.70247 CircRYR2: A Novel Regulator of Cardiac Hypertrophy October 2025 Heart failure is driven by pathological cardiomyocyte hypertrophy and impaired calcium handling. Our present study identifies circRYR2, a circular RNA derived from the RYR2 locus, as a key regulator of these processes. CircRYR2 expression is reduced in both hypertrophic murine hearts and human failing heart tissue. Loss of circRYR2 promotes cardiomyocyte hypertrophy, while its overexpression prevents pathological growth and improves calcium handling by regulating SERCA2a and calcium transients. These findings reveal circRYR2 as a promising therapeutic target for cardiac dysfunction. Please find the original article here: https://link.springer.com/article/10.1007/s00018-025-05915-2 Type I Interferons Shape SARS-CoV-2 Responses in Human Heart and Immune Cells October 2025 The role of type I interferons (IFNs) in COVID-19 severity remains incompletely understood. Using human iPSC-derived cardiomyocytes and macrophages with intact or deficient IFNAR1 signaling, this study reveals distinct, cell-type–specific effects of type I IFNs. Cardiomyocytes supported robust SARS-CoV-2 replication, which was significantly increased in IFNAR1-deficient cells and reduced by IFNα treatment in IFNAR1-competent cells, but not in IFNAR1-deficient cells. In contrast, macrophages did not permit viral replication but mounted strong pro-inflammatory cytokine responses upon viral exposure, a process dependent on intact type I IFN signaling. These findings highlight the dual role of type I IFNs in limiting viral replication in cardiac cells while promoting immune activation in macrophages. Please find the original article here: https://link.springer.com/article/10.1007/s10875-025-01943-6 Advancing Cardiotoxicity Research: Zeinab Mroue Highlights IMTTS Research at the Cardio-Immune Interfaces Summer School September 2025 Zeinab Mroue participated in the Cardio-Immune Interfaces Summer School held at the DZHI in Würzburg from 3–5 September 2025. As the only first-year PhD student among the ten presenters, Zeinab had the opportunity to present her PhD project on the cardiotoxicity of immune checkpoint inhibitors. We congratulate Zeinab on her excellent representation of IMTTS and her valuable contribution to advancing research in cardiotoxicity. RNA-Based Telomerase Therapy Shows Promise for Treating Pulmonary Fibrosis September 2025 Pulmonary fibrosis (PF) is a severe, progressive lung disease characterized by lung tissue scarring. The median life expectancy after diagnosis is only 4-6 years. Current treatments can only slow the progression of the disease, which highlights the urgent need for innovative therapies. In a recent study, researchers from the IMTTS explored the use of RNA-based telomerase therapy to treat PF. Since patients with PF often exhibit telomere shortening, we examined the use of human telomerase reverse transcriptase (hTERT) mRNA with modified nucleosides (modRNA) to restore telomerase activity. Treatment with modRNA hTERT increased telomerase activity, enhanced cell proliferation, reduced DNA damage, and elongated telomeres in lung cells - all of which are key signs of cellular rejuvenation. Importantly, immune activation was minimal and transient. A circularized, exonuclease-resistant version of modRNA hTERT further increased expression, suggesting potential clinical benefits. Finally, in three-dimensional (3D) ex vivo human lung tissue from patients with PF, a single modRNA hTERT treatment reduced cell senescence and decreased inflammatory (IL6, IL8) and fibrotic (TGFβ, COL1A1) markers. These results demonstrate the therapeutic potential of RNA-based hTERT therapy in treating pulmonary fibrosis. Please find the original article here: https://doi.org/10.1111/acel.70240 Left ventricular hypertrophy and myocardial fibrosis in heart failure with preserved ejection fraction: mechanisms and treatment September 2025 Heart failure with preserved ejection fraction (HFpEF) accounts for nearly half of all heart failure cases and is often linked to comorbidities such as hypertension, obesity, and diabetes. These conditions contribute to cardiac remodeling and myocardial fibrosis, leading to left ventricular hypertrophy, increased stiffness, and poor outcomes. Despite recent advances, no current therapies directly target myocardial fibrosis or left ventricular hypertrophy in HFpEF. Recognizing these mechanisms as central to HFpEF pathophysiology could pave the way for new, targeted treatments. Our recent review highlights the role of fibrotic remodeling and left ventricular hypertrophy in HFpEF. It also discusses current diagnostic approaches and emerging therapeutic strategies that aim to directly modulate myocardial fibrosis and hypertrophy to improve patient outcomes. Please find the original article here: https://doi.org/10.1093/eurheartj/ehaf524 Fraunhofer CIMD Symposium RNA-Based Therapeutics – News, Networking, and Awards September 2025 The Fraunhofer CIMD recently hosted the highly anticipated Symposium on RNA-Based Therapeutics, which was expertly organized by Prof. Dr. Christian Bär. The event featured a compelling keynote address by Prof. Dr. Dr. Thomas Thum, who highlighted the latest advances in RNA research and its therapeutic potential. Several students from IMTTS had the opportunity to participate in the second Fraunhofer CIMD Symposium on RNA-Based Therapeutics 2025. The event showcased cutting-edge research on innovative RNA manufacturing, delivery methods, and therapeutic applications, fostering insightful discussions among attendees. Elisa Mohr, a PhD student, was selected from the submitted abstracts to present her project, “Versatile Multicellular Human Cardiac Organoids as an In Vitro Platform for Modeling Cardiovascular Diseases,” in a rapid-fire presentation. Additionally, Dr. Shambhabi Chatterjee, a junior group leader, and Anita-Koula Pralas, PhD student, received awards for their outstanding poster presentations, titled “Telomerase modRNA therapy confers anti-fibrotic and anti-senescent effects against human pulmonary fibrosis” and “Therapeutic targeting of TGFß1-Responsive lncRNAs for Cardiac Fibrosis Intervention”. Congratulations! Towards a Unified Nomenclature for Circular RNAs September 2025 Circular RNAs (circRNAs) have gained attention as key regulators in posttranscriptional gene regulation, distinguished by their stable, closed-loop structure and diverse biological functions. However, the lack of a standardized naming system has created confusion and limited effective communication across the field. Our new book chapter traces the evolution of circRNA research and emphasizes the urgent need for a unified nomenclature. It discusses the role of circRNA databases, the challenges posed by identifying multiple circRNAs from single gene loci, and proposes a systematic naming approach based on the “circ” prefix, GENCODE/Ensembl transcript references, and annotations for unique structural features. Adopting a consistent nomenclature will be key to improving clarity, reproducibility, and collaboration in circRNA research moving forward. Please find the book chapter here: https://doi.org/10.1007/978-981-96-9428-0_2 Snow in July on Germany’s Highest Mountain July 2025 From July 9th to 11th, Sedef Ersoy and Alina Umlauf participated in a gender workshop organized by the SFB / TRR 267. The workshop focused on improving communication and presentation skills. It took place at the Schneefernerhaus on Zugspitze, Germany’s highest mountain. Against this impressive natural backdrop, both participants gained valuable knowledge and practical experience. Dr. Erika Hilbold Receives Prestigious Simic-Grau Award July 2025 We are pleased to announce that Dr. Erika Hilbold, an IMTTS scientist, has been honored with the prestigious Simic-Grau Award at the 35th European Association of Veterinary Anatomists (EAVA) Congress, which took place from July 22 to 25, 2025, in Toulouse, France. This award recognizes excellence in oral presentations and outstanding scientific contributions to the broad field of comparative veterinary anatomy. Dr. Hilbold received the award for her enthusiastic oral presentation entitled “Investigating long non-coding RNAs in the regenerating mouse heart.” This accomplishment emphasizes the importance of Dr. Hilbold’s research beyond the cardiovascular field, and we congratulate her on this well-deserved recognition. Fruitful Days of Scientific News and Networking at the 35th EAVA Congress July 2025 IMTTS scientist Dr. Erika Hilbold participated in the 35th EAVA (European Association of Veterinary Anatomists) Congress in Toulouse, France. The congress focused on anatomy in all its aspects - gross, histologic, developmental, and biological - as applied to clinical practice, teaching, and research, with the goal of expanding anatomical knowledge. EAVA’s diverse membership includes professionals with extensive backgrounds in research, clinical practice, education, and administration from across Europe and the world. Dr. Hilbold had the opportunity to engage with this vibrant community, exchanging insights and discussing the importance of having an extensive knowledge of mouse and human histomorphology in order to conduct successful research. Generation of a human induced pluripotent stem cell reporter line to investigate cell division and proliferation July 2025 We have developed a novel human induced pluripotent stem cell (hiPSC) reporter line expressing cyclinB1-eGFP, enabling live tracking of proliferating cells across multiple lineages. This reporter line retains pluripotency and can be efficiently differentiated into cardiomyocytes, endothelial cells, and fibroblasts. The cyclinB1-eGFP system allows real-time identification and sorting of cells in active cell cycle phases (S/G2/M), providing a powerful platform for studying human cell division dynamics. This innovative tool also facilitates screening of pro-proliferative compounds, accelerating research into regenerative therapies and disease mechanisms. Please find the original article here: https://doi.org/10.1016/j.scr.2025.103776 Thum Lab Enjoys a Successful Annual Excursion July 2025 The Thum Lab recently held its annual excursion, marking a successful and enjoyable day for the entire team. While scientific excellence and hard work define our daily efforts, creating a positive and healthy work environment is equally important. This outing provided a valuable opportunity to step away from the lab, strengthen team bonds, and recharge in a relaxed setting. Events like these play a key role in fostering collaboration and maintaining a strong, motivated team. We sincerely thank Professor Dr. Dr. Thomas Thum for his continued support and for making this great day possible. EMBO Workshop in Italy: Advancing circRNA Research June 2025 Alina Umlauf, a PhD student at IMTTS, had the great opportunity to participate in the EMBO Workshop "gROUNDbreaking Approaches for Advancing circRNA Research: Detection, Function, Therapeutics" held in Trento, Italy, from May 31 to June 6. Under the guidance of leading experts in the field of circular RNA (circRNA), she gained valuable insights into the latest developments and methodologies in circRNA research. The workshop combined expert talks with hands-on sessions focused on specialized techniques for detecting and studying circRNAs. During the event, Alina also presented her own work and received valuable feedback and new ideas to advance her research. In addition to the scientific program, the workshop provided numerous opportunities for networking and exchange with other participants and researcher. Congratulations to Marco Bentele on successfully defending his doctoral thesis June 2025 Marco Bentele was enrolled in the PhD program “Molecular Medicine” and has successfully defended his doctoral thesis entitled “Investigating cardiac diseases in miniaturized LMS from human cardiac samples”. Congratulations to Jia Li Ye on the successful defense of her doctoral thesis June 2025 Jia Li Ye was enrolled in the PhD program “Regenerative Sciences” and has successfully defended her doctoral thesis entitled “Modulating telomerase activity for the treatment of aging-associated disease”. IMTTS Researcher Sedef Ersoy Receives CBCS Poster Prize June 2025 Sedef Ersoy, a PhD student at the IMTTS, has been awarded the Poster Prize by the Council on Basic Cardiovascular Science (CBCS) for her presentation entitled “Functional investigation of circular RNA in cardiac development and disease.” As part of this recognition, Sedef has been invited to attend the “Frontiers in CardioVascular Biomedicine (FCVB) Congress 2026” with complimentary registration. This achievement highlights the significance of Sedef’s research, and we congratulate her on this well-earned recognition. CBCS Summer School 2025: A Valuable Experience for Young IMTTS Scientists June 2025 Organized by the European Society of Cardiology, the CBCS Summer School in Nice/Sophia Antipolis offers young scientists a unique opportunity to deepen their knowledge in basic cardiovascular science and to build connections with researchers across Europe. This year, IMTTS PhD students Sedef Ersoy and Shubham Rana were thrilled to participate in the event. They presented their projects in a poster session, engaging with peers and experts to discuss their research. The four-day program was packed with inspiring talks covering cutting-edge topics in cardiovascular research, providing a stimulating environment for learning and collaboration. Lea Oehlsen Participated in the World’s Leading Event on Heart Failure May 2025 In May 2025, Lea Oehlsen, a PhD student at IMTTS, presented her latest research during a rapid-fire session at the World Congress on Acute Heart Failure (HFA 2025) held in Belgrade, Serbia. This prestigious event was organized by the European Society of Cardiology. Lea’s work was exceptional and was featured in the Highlights of HFA 2025 session on the last day of the conference. This session showcased the program's most outstanding contributions. We congratulate Lea on her excellent representation of IMTTS and her valuable contribution to the field of acute heart failure research. Hands-On Training in Ultrasound and Photoacoustic Imaging with Visual Sonics in Amsterdam May 2025 IMTTS researchers recently participated in an intensive multimodality workshop organized by Visual Sonics in Amsterdam. The workshop offered hands-on training and expert insights into advanced ultrasound and photoacoustic imaging techniques, empowering researchers to enhance their cardiovascular studies with state-of-the-art technology. This event provided an excellent opportunity to deepen practical skills and foster collaboration within the imaging community. IMTTS Showcases Groundbreaking Cardiovascular Research at the 91st Annual DGK Conference April 2025 The IMTTS was once again well represented at the 91st annual meeting of the German Society of Cardiology (DGK), held in Mannheim from April 23 to 26. The IMTTS presented their work in two poster sessions, “From cells to organism” and “Ageing”, as well as in the Basic Science session, where they gave three talks on “Non-coding RNAs”. Notably, presentations by Prof. Christian Bär and Prof. Thomas Thum covered important topics related to cardiac regeneration and non-coding RNAs as biomarkers and in cardiovascular research. Additionally, Eric Alberti, Mary Basta Badres, Ayse Boese, Shirin Dildebekova, Constantin Epping, Franziska Herbig, Zeinab Mroue, Lea Oehlsen, and Peter Spenger received travel stipends from the Young DGK Section. Empowering the Next Generation: Experiences at ESGCT’s Spring School April 2025 The 2025 ESGCT Spring School was held in Potsdam from April 8–11 and was organized by the European Society of Gene and Cell Therapy (ESGCT). The program brought together early-career researchers to expand their knowledge of current gene and cell therapy developments, while promoting collaboration and networking. IMTTS PhD students Laura Trumann and Shubham Rana participated in the four-day program, which featured lectures, workshops, and interactive discussions. Leading experts contributed to the program by sharing their knowledge during the sessions and engaging with participants at social events, thereby creating a stimulating and supportive learning environment. Anti-senescence therapies: a new concept to address cardiovascular disease February 2025 The accumulation of senescent cells contributes to cardiovascular disease through the pro-inflammatory and matrix remodeling molecular program, known as the 'senescence associated secretory phenotype' (SASP), driven by (epi)genetic changes. Emerging therapies such as senolytics, anti-SASP senomorphics, and epigenetic reprogramming aim to target senescence, with some clinical drugs also showing anti-senescence effects. Our comprehensive review provides a guide to understanding senescence biology, systematizes anti-senescence treatments, and proposes a pathway for designing clinical trials to assess their effectiveness. The publication can be found here: https://academic.oup.com/cardiovascres/advance-article/doi/10.1093/cvr/cvaf030/8046207?login=true IMTTS scientist Dr. Erika Hilbold receives DGK Research Fellowship January 2025 The German Society of Cardiology-Cardiovascular Research e.V. (DGK) has awarded Dr. Erika Hilbold with the DGK Research Fellowship. Her research project “Elucidating the functional requirement of long non-coding RNA H19 in neonatal cardiac regeneration” will be funded by the DGK for one year. The project aims to test the potential of H19 as an RNA-based intervention to extend the cardiac regenerative window in newborn mice and to identify involved pathways. Congratulations to Arne Schmidt for successfully defending his doctoral thesis December 2024 Arne Schmidt has successfully defended his doctoral thesis entitled “The role of circular RNAs in cardiac energy metabolism”. IBT Lower Saxony funds the IMTTS project LuFex with 800,000 € Copyright: Christiane Bock von Wülfingen November 2024 Tissue degeneration, including fibrosis, can affect various organs, such as the lungs, and is responsible for around 50% of deaths in industrialized countries. A key event in organ fibrosis is the activation of local fibroblasts, which results in organ stiffness, insufficient oxygen supply, and ultimately organ dysfunction. LuFex aims to develop a new inhaled therapy using a plant-based anti-fibrotic drug, with idiopathic pulmonary fibrosis as the first disease to test this treatment. The project is funded by the Institute for Biomedical Translation (IBT) Lower Saxony in the amount of 800,000 € for a period of two years. Read more about LuFex here: https://www.mhh.de/en/presse/mhh-insight/news-detailed-view/natural-substance-spray-against-pulmonary-fibrosis https://www.ibt-ls.de/projekte For the fifth time, Professor Thomas Thum is one of the world's most cited researchers November 2024 The world's most cited researchers of 2024 have been identified by “Clarivate Analytics”. These scientists have produced multiple highly cited papers ranking in the top 1% of Web of Science™ citations by field and year over the past decade. IMTTS Director Professor Dr. Dr. Thomas Thum is one of these scientists for the fifth time. He is listed this time in the category “Cross-Field”. The current list of Highly Cited Researchers (https://clarivate.com/highly-cited-researchers/) includes 6,886 researchers from 21 disciplines in natural, life and social sciences. Spooky Season at IMTTS October 2024 Our team is celebrating Halloween with a festive outing full of costumes, fun, and team spirit. It’s a great chance to connect, unwind, and enjoy some seasonal fun together! Small worm, big breakthrough - Nobel Prize in Medicine 2024 for the discovery of microRNA October 2024 This year's Nobel Prize in the Physiology or Medicine category goes to two US scientists, Victor Ambros and Gary Ruvkun, for their “groundbreaking discovery” of microRNA and its role in post-transcriptional gene regulation. It all began with a small worm, C. elegans, which despite its small size of around 1mm has various specialized cell types such as muscle cells and neurons and is therefore a popular model organism in basic research. While studying this worm, Ambros and Ruvkun discovered small RNA molecules that are not translated into specific proteins, which was previously the generally accepted function for RNA. The latter is still true today for the so-called “messenger RNA or mRNA”. MicroRNA, on the other hand, plays an important role in gene regulation. It is highly conserved between different species and at least 1000 different microRNAs have now been discovered in humans. MicroRNAs are “fundamentally important” for multicellular organisms, as they control a variety of cellular processes, such as cell growth, cell division and cell differentiation. This makes it possible for cells to specialize into different cell types with a unique composition of proteins despite having the same genetic information. The microRNAs can therefore significantly influence the development and function of the organism. Consequently, abnormal microRNA activity leads to changes in gene regulation and can result in serious diseases such as cancer, diabetes or immune disorders. Rapidly gained knowledge about the functions of microRNAs as well as the good conservation between the different species enabled the development of new therapeutic approaches. On the one hand, a lack of microRNAs can be compensated for by synthetically produced microRNAs. On the other hand, so-called antisense oligonucleotides (ASOs) can be used to block excess microRNAs. Research into these microRNA functions and the development of new therapeutic strategies for cardiovascular diseases is a major focus of Professor Thum's Institute of Molecular and Translational Therapeutic Strategies (IMTTS) at Hannover Medical School (MHH). Over a decade ago, IMTTS scientists discovered that an excessive presence of microRNA 132 (miR-132) is directly linked to cardiac hypertrophy. Professor Thum's team was subsequently able to show that inhibiting miR-132 can prevent cardiac remodeling and thus preserve cardiac function. In order to further develop this promising candidate as a therapy, the MHH spin-off Cardior Pharmaceuticals GmbH was founded. Cardior has shown in Phase I clinical trials that the first non-coding RNA-based therapy to combat heart failure, the antisense oligonucleotide blocker CDR132L, is safe and well tolerated in patients with heart failure. CDR132L is presently being tested in a phase II clinical trial (HF-REVERT). With 280 patients enrolled, this is currently the largest microRNA study worldwide. The acquisition of Cardior Pharmaceuticals GmbH by Novo Nordisk in May 2024 underlines the importance of basic university research at the MHH and enables “the late-stage development program to be further accelerated through larger approval studies and to move towards market approval,” says Professor Thum. In summary, Ambros and Ruvkun's discovery paved the way for the development of RNA-based therapies that have great potential for the treatment of cardiovascular diseases and beyond. In particular, the modulation of microRNAs is a key approach in the development of innovative therapies for challenging diseases. Strengthening Expertise in Stem Cell Research on the Greek Island of Spetses September 2024 From September 12 th to 23 rd , 2024 , PhD student Ayse Boese attended the 19th European Summer School on Stem Cell Biology and Regenerative Medicine , held on the Greek island of Spetses. This summer school brings together doctoral students and postdoctoral researchers for an intensive week of lectures and discussions with leading scientists on both the fundamentals and the latest developments in stem cell research. The event provided valuable opportunities for professional exchange and insight into current research projects from across the field. In addition, Ayse had the opportunity to present her own research and received valuable, constructive feedback. The program’s atmosphere in general fostered open dialogue with the speakers, enabling in-depth discussions and contributing to the establishment of important professional contacts. Copyright: J. N., Stem Cell Education and Research Elisa Mohr and Philipp Höhne receive Poster Awards September 2024 The Fraunhofer CIMD Symposium "RNA-Based Therapeutics" took place on September 30 and brought together experts from academia and industry in the field of RNA-based therapeutics. IMTTS scientists Elisa Mohr and Philipp Höhne received the Poster Award for their excellent poster presentations. Elisa Mohr presented "Cardiovascular diseases in 3D: Human organoids as a multipurpose tool to recapitulate cardiac pathophysiology in vitro". Philipp Höhne gave a presentation on "Superparamagnetic nanoparticles as cardiac-targeted delivery tools for ncRNA therapeutics". Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine September 2024 The present study investigated the role of ferroptosis in cardiac injury using rat and human living myocardial slices (LMS) and found that ferroptosis is a key driver of cardiac injury and fibrosis. Pharmacological inhibition of ferroptosis with ferrostatin-1 (Fer-1) improved cardiac function, reduced fibrosis, and enhanced tissue viability in both rat and human heart models. Metallothioneins were identified as potential mediators of ferroptosis inhibition, suggesting that targeting ferroptosis-related pathways may offer a novel therapeutic strategy for heart disease. Please find the original article here: https://www.sciencedirect.com/science/article/pii/S0022282824001615?via%3Dihub A reporter system for live cell tracking of human cardiomyocyte proliferation August 2024 We have developed a human induced pluripotent stem cell (hiPSC) fluorescent reporter line to track and sort replicating cardiomyocytes, overcoming the limitations of traditional cell proliferation assays. The system allows live-cell labeling of proliferating cells, enabling high-throughput screening of potential pro-regenerative drugs or conditions. This tool provides a novel in vitro platform to advance cardiomyocyte proliferation and cardiac regeneration research. Please find the original article here: https://academic.oup.com/cardiovascres/article/120/14/1660/7739742?login=true Discontinuation of afterload-reducing drugs decreases left ventricular outflow tract obstruction in hypertrophic obstructive cardiomyopathy July 2024 Hypertrophic cardiomyopathy, the most common genetic heart disease and it is classified into hypertrophic non-obstructive and hypertrophic obstructive cardiomyopathy (HOCM). In this study, we have examined the effects of discontinuing afterload-reducing medications in patients with HOCM. Results showed a significant reduction in the left ventricular outflow tract (LVOT) gradient in patients who stopped these medications, particularly in those with hypertension or heart failure. The findings support discontinuing afterload-reducing drugs and emphasize the use of beta-blockers or non-dihydropyridine-calcium channel blockers as preferred treatments for HOCM. Read more here: https://www.frontiersin.org/journals/cardiovascular-medicine/articles/10.3389/fcvm.2024.1403422/full Breathtaking Stem Cell Research and Abstract Merit Award for Dr. Chatterjee July 2024 The 2024 Annual Meeting of the International Society for Stem Cell Research (ISSCR) was held July 10-13 at the Congress Center in Hamburg, Germany, where stem cell scientists from around the world gathered to discuss exciting discoveries. There were three poster presentations from IMTTS on the topics of stem cell based investigation of cardiac development (Dr. Shambhabi Chatterjee), cardiac proliferation (Prof. Christian Bär) and even a 3D multicellular cardiac model systems for recapitulating cardiovascular diseases in vitro (Ms. Elisa Mohr). Attending the ISSCR2024 was a great networking experience for IMTTS researchers and on top Dr. Chatterjee was also one of the recipients for the ISSCR2024 Abstract Merit Award putting IMTTS research on the forefront. Congratulations to Dr. Chatterjee! DGK funds a new research project July 2024 IMTTS scientist Dr. Hannah Hunkler received a 49,940 € grant for her research project “Specific degradation of Rho kinases by proximity-inducing drugs as a therapeutic strategy against heart failure in vivo ” funded by the DGK for a period of one year. This project aims to test the most potent anti-fibrotic and anti-hypertrophic PROTACs (proteolysis targeting chimeras) in mouse models of heart failure. DFG grant to study TERT telomere length-metabolism in relation to cardiac damage and regeneration May 2024 IMTTS’s principal investigator Professor Dr. Christian Bär and Dr. Shambhabi Chatterjee received a 354,898 € grant for the research project “Functional requirement of telomere length and telomerase in the regulation of mitochondrial reactive oxygen species in cardiomyocyte health and disease” funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) for a period of three years. The project aims to untangle both mechanisms and interactions of the TERT-telomere length-mitochondria axis in cardiovascular stress conditions and gain deeper insights into TERT’s potential to elicit cardiac regenerative responses. Prestigious Young Investigator Award 2024 for Elisa Mohr May 2024 Elisa Mohr, a PhD student at the Institute of Molecular and Translational Medicine (IMTTS) at Hannover Medical School, received the Young Investigator Award 2024 at Cardioascona 2024 in Ascona, Switzerland, for her work on "Cardiovascular diseases in 3D: the versatility of cardiac organoids as multipurpose tool to recapitulate the human heart in vitro". Congratulations Elisa! Please visit https://cardioascona.com/awards Fascination Cardiomyocytes – Cardioascona 2024 May 2024 IMTTS scientists Dr. Shambhabi Chatterjee and Elisa Mohr had the opportunity to participate in the 11th International Ascona Workshop on Cardiomyocyte Biology in Ascona, Switzerland. During Cardioascona 2024, Richard Harvey, Jennifer Davis, Benjamin Prosser, Lucie Carrier, Roger Foo and many other experts in the field discussed their projects, recent advances and future directions of cardiac research with the participants. Both IMTTS members presented their ongoing projects in lively poster sessions. In summary, a workshop well worth the 11 hours of travel. New drug against heart failure successfully tested at MHH – SAT.1 TV report May 2024 At the IMTTS, new therapies are being investigated on an innovative ex vivo system - living human myocardial slices. For the first time, a new drug against heart failure was successfully tested on this living human heart tissue, resulting in a partial regression of fibrosis, which led to more elastic heart tissue and heart muscle cells that were able to relax more during beating, along with an increased viability. Please watch the report here: https://www.sat1regional.de/neues-medikament-gegen-herzschwaeche-erfolgreich-an-mhh-getestet/ The original publication can be found here: https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehae102/7619354 Acquisition of IMTTS spinoff Cardior Pharmaceuticals by Novo Nordisk A/S officially completed May 2024 The transaction for the acquisition of Cardior Pharmaceuticals by Novo Nordisk A/S has been formally completed with the receipt of all regulatory approvals. As of May 2, 2024, Cardior Pharmaceuticals is a wholly owned subsidiary of Novo Nordisk A/S. The transition process is currently under way. "In Novo Nordisk, we have found an ideal partner with broad clinical and commercial expertise and a growing portfolio of cardiovascular product candidates that will enable us to further accelerate our late-stage development program through larger pivotal trials and toward market approval," said IMTTS Director and Cardior CEO Professor Thum. The lead compound, CDR123L, is a synthetic antisense oligonucleotide and a selective inhibitor of microRNA‑132‑3p (miR-132). miR-132 expression is associated with pathological cardiac remodeling and heart failure. Basic investigations of mir-132 and the preclinical development of a miR-132 inhibitor for heart failure treatment have been performed at the IMTTS. Thereafter, IMTTS spin-off Cardior Pharmaceuticals took care of CDR123L’s translational development. In order to further advance CDR123L towards regulatory approval, Novo Nordisk plans to initiate a second Phase 2 trial to evaluate CDR123L in a chronic heart failure population. Telomerase is essential for cardiac differentiation and sustained metabolism of human cardiomyocytes April 2024 Linear eukaryotic chromosomes are protected by special nucleoprotein structures known as ‘telomeres’ which are synthesized by the enzyme telomerase. The telomere length is a biomarker for ageing and it is well-known that patients suffering from cardiovascular diseases have shorter telomeres compared to their age-matched healthy subjects. However, it is not clear whether loss of telomeres leads to cardiac dysfunction or whether cardiac damage causes the shortening of telomeres. In order to answer this biological question, IMTTS scientists have generated a sophisticated platform for producing human cardiomyocytes in vitro which possess either long or short telomeres. This was achieved by establishing a CRISPRi TERT human induced pluripotent stem cell (hiPSC) line, which enables modulation of telomerase activity and telomere length at will. Furthermore utilizing the power of hiPSC differentiation protocols, these cells can be differentiated into cardiomyocytes (or any other cell type of choice) in vitro in a dish for functional assays. This research work spearheaded by Dr. Shambhabi Chatterjee under supervision of Prof. Dr. Christian Bär, shows for the first time how the presence of telomerase activity and telomere length is crucial for cardiomyogenesis, contractility and mitochondrial function. In the next steps, Dr. Chatterjee as part of her DHKT-funded project will apply this platform for telomere-driven disease modelling and drug screening purposes for cardiomyocytes. However, this novel tool is applicable to all other cell types, which can be differentiated from hiPSCs making it an extremely valuable model for telomere and ageing research. Please find the original article here: https://link.springer.com/article/10.1007/s00018-024-05239-7 Read more here: https://www.mhh.de/en/presse/mhh-insight/news-detailed-view/was-die-schutzkappen-unserer-dna-mit-der-herzgesundheit-zu-tun-haben Biomarkers 2024 April 2024 Professor Thomas Thum and Professor Christian Bär discussed the latest news on the role of biomarkers and omics in promoting cardiovascular science and care with academic, clinical, and industry leaders in a work group environment at the 19th Annual Meeting of the Transatlantic Heart Failure Biomarker Working Group in Cannes, France, on April 27-28, 2024. Fruitful presentations, discussions & networking at the Keystone Symposium April 2024 The Keystone Symposium on Cardiovascular Epigenetics and Gene Regulation was held at the Herrenhausen Palace in Hannover from April 15 to 18, and several of IMTTS researchers contributed to it. There were five poster presentations and three were selected for short talks as well, encompassing the topics of cardiac development, proliferation, 3D multicellular cardiac model systems and lncRNA-candidates aimed for developing novel therapeutic strategies to treat cardiovascular diseases. The symposium provided the perfect opportunity to make new friends and re-connect with several old ones. Sweat, ambition and fun - the "ADAC Hannover Marathon Staffellauf 2024" April 2024 For the first time, the IMTTS formed a team to participate in the "ADAC Hannover Marathon Staffellauf" on Sunday, April 14, 2024. In bright sunshine, our motivated IMTTS members enjoyed running the six marathon stages and finished the 42.195 kilometers in under 4 hours. Our team thanks the Hannover Medical School (MHH) for their support. This year, the MHH was represented by 250 motivated employees from medicine, nursing, research and administration, who joined together in 42 relay teams to complete the "Marathon Staffellauf". IMTTS researcher Anita-Koula Pralas receives DGK poster prize April 2024 Anita-Koula Pralas, a PhD student at the Institute of Molecular and Translational Medicine (IMTTS) at Hannover Medical School, was awarded the prestigious poster prize from the German Cardiac Society (DGK) at the society’s annual conference in Mannheim for her poster entitled “The role of the lncRNA MEG3 in cardiovascular disease and cardiac unloading”, which was selected out of hundreds of posters. This poster delves into the role by which MEG3 influences cardiac fibrosis and is a part of the FIBREX project, funded by the European Innovation Council. Congratulations Anita!!! Excellent days at the annual meeting of the DGK April 2024 This year's 90th Annual Meeting of the German Society of Cardiology (DGK) was held in Mannheim from April 3 to 6, and our group was well represented as usual. With a total of eight posters, out of which we had: 1 poster prize, 1 poster nomination, and 2 posters in the session of the DGK research fellows (DGK - Stipendiaten - Sitzung), we had a lot to celebrate! There were six presentations between Prof. Christian Bär and Prof. Thomas Thum, covering; cardiac regeneration, fibrosis therapy, cardio-oncology, cardio-toxicity, lncRNAs, circRNAs, and of course, celebrating the new advances in the miRNA-132 story that cumulated with the recent purchasing of Cardior Pharmaceuticals by Novo Nordisk last week. These were all exciting and welcoming news to share with other conference attendees to update the field in German cardiology. All in all, a very successful conference! CAIMed - Lower Saxony Center for AI & Causal Methods in Medicine March 2024 CAIMed develops innovative methods for improved, personalized healthcare and thus contributes to overcoming widespread diseases such as cancer, cardiovascular diseases and infections. The combination of excellent locations in Lower Saxony for methodological research in artificial intelligence (AI), data-intensive medicine, medical informatics and basic medical research will create a unique beacon for research in AI and personalized medicine. IMTTS Director Professor Thomas Thum is one of the mentors of the "Semantic Models in Medicine" junior research group, which is part of the "AI & Active Agents" methodological cluster. This junior research group will explore techniques to orchestrate symbolic, causal reasoning and machine learning to improve the interpretability of AI on medical knowledge from relevant literature, ontologies and databases. These semantic models and hybrid AI methods will be used, for example, to predict interactions and discover patterns to identify RNAs in cardiovascular disease and pulmonary fibrosis and to develop RNA-targeted therapies. Read more about CAIMed here: https://caimed.de/en/ https://www.mhh.de/en/presse/mhh-insight/news-detailed-view/constitutive-supervisory-board-meeting-of-the-lower-saxony-centre-for-ai-and-causal-methods-in-medicine Living myocardial slices for testing new drugs and innovative heart failure therapies March 2024 In a recent study, IMTTS scientists demonstrated for the first time that inhibition of microRNA (miR) - 21 has a cardioprotective effect in human heart tissue. As a new method, the study used "living myocardial slices" (LMS). The material was provided by the Clinic for Cardiac, Thoracic, Transplantation and Vascular Surgery at the MHH and is, so to speak, tissue waste from diseased hearts that have been removed as part of a transplant. These myocardial slices continue to live and beat for many days or weeks in a nutrient solution. The transplants were necessary because the hearts could no longer function properly due to cardiac insufficiency, also known as heart failure. The heart, weakened by a heart attack or high blood pressure, tries to compensate for its reduced pumping capacity by increasing its own volume: The heart gets stronger and stronger, overtaxing itself. This often leads to the proliferation of connective tissue cells (fibroblasts) in the heart muscle, which stiffen the heart and lead to fibrosis. "miR-21 plays a decisive role in this development," says Professor Thum. His team investigated what happens when the harmful function of miR-21 is switched off. They used a so-called antisense molecule, which attaches itself to the microRNA in a mirror image and can thus block it. "We added the blocker to the cultivation chambers in which our LMS from the explanted, fibrosis-damaged hearts were living," explains the cardiologist. The researchers observed a partial regression of fibrosis in the tissue sections. As a result, the tissue became more elastic, the heart muscle cells were able to relax more during beating, and their viability increased. "To our knowledge, this is the first study to directly investigate the effects of miR-21 in living human heart tissue," says Professor Thum. The LMS model has proven its value in providing preclinical evidence of efficacy and should help to significantly reduce animal testing in the future. "The tests in the cultivation chambers have shown that the miR-21 blocker is a potential drug candidate for stopping and even reversing the development of fibrosis in heart failure. Since fibrosis can also affect other organs, the antisense molecule could also be considered for the treatment of liver or lung fibrosis. "In addition, heart failure is often associated with concomitant diseases in organs such as the liver and kidneys, so suppressing miR-21 might also be beneficial in cases of impaired liver and kidney function," the scientist assumes. The next step will be to clarify how the blocker can be delivered safely and precisely to the desired target. IMTTS scientists are already working on a solution that should make it possible to deliver RNA therapeutics to different organs in the future. Please find the original article here: https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehae102/7619354 Read more here: https://www.mhh.de/en/presse/mhh-insight/news-detailed-view/living-heart-muscle-slices-drive-rna-research-into-heart-failure R-CUBE, MHH's excellence cluster initiative led by Professor Thum, reaches the final round February 2024 The draft proposal for "R-CUBE - Organ Regeneration, Repair and Replacement" convinced the German Research Foundation (DFG) and the German Council of Science and Humanities. The MHH Cluster of Excellence Initiative was invited to submit a full proposal from among the draft proposals for new clusters of excellence submitted as part of the Excellence Strategy. R-CUBE is one of 41 draft proposals selected for the final round. Nationwide, 143 draft proposals were submitted. The new Cluster of Excellence will receive up to 10 million euros per year for seven years if the proposal is selected in the final round. The decision on which clusters of excellence will be funded will not be taken until May 2025, and the new seven-year funding period will begin on January 1, 2026. "The successful performance of R-CUBE in Germany's most important research competition strengthens MHH's position as a leading institution in international transplantation and regeneration research," said MHH President Prof. Dr. Michael Manns. "Despite increasingly fierce competition, we are holding our own in the top group of university medical research institutions - not only in Germany, but also in Europe. I warmly congratulate the team led by Prof. Dr. Dr. Thomas Thum". "The funding would provide us with an exciting opportunity to further advance our vision and make groundbreaking progress in the field of organ repair and replacement," adds Professor Thum. Current therapies for organ failure are symptomatic, and the shortage of donor organs places an additional burden on patients and their families. R-CUBE is a translational research consortium that aims to strengthen clinical practice and research in advanced organ failure to improve patient care. R-CUBE will develop multimodal diagnostic tools for personalized treatment that will support organ regeneration and repair and provide novel strategies for organ replacement. Read more here: https://www.mhh.de/en/presse/mhh-insight/news-detailed-view/mhh-may-submit-full-proposal-for-new-cluster-of-excellence Macrophage-based therapeutic approaches for cardiovascular diseases January 2024 Cardiovascular diseases (CVDs) remain the leading cause of global mortality despite advancements in drug therapies. Recent research highlights the potential of macrophages, the most abundant immune cells in the heart, as therapeutic targets in CVDs. Macrophages play a critical role in regulating inflammation and fibrosis, key processes in disease progression. However, macrophage-based therapies for CVDs require careful implementation due to their dynamic changes and double-edged phenotypes. To achieve personalized treatment strategies, a thorough understanding of macrophage heterogeneity and plasticity is crucial. Our review explores the multifaceted roles of macrophages in specific CVDs, including atherosclerosis, myocardial infarction (MI), and heart failure with preserved ejection fraction (HFpEF). We delve into potential macrophage-targeting strategies for each condition, emphasizing novel non-coding RNAs and potential biomarkers. Recognizing the current limitations, we also propose advanced models for studying macrophages in the context of CVDs to bridge the gap between research and clinical application. Ultimately, our review provides a comprehensive understanding of macrophages and paves the way for the development of optimal and clinically relevant macrophage-based therapies for specific CVDs. The publication can be found here: https://link.springer.com/article/10.1007/s00395-023-01027-9 Prestigious DHKT Research Award 2024 for Dr. Shambhabi Chatterjee January 2024 IMTTS researchers Dr. Shambhabi Chatterjee and Mrs. Jia Li Ye attended the “Dresdner Herz-Kreislauf-Tage 2024”, 26-28 January 2024 in Dresden, Germany. During this conference Dr. Chatterjee was awarded with the “Forschungspreis 2024” worth 20,000 € for her research proposal entitled “Novel targets to treat hypertrophic cardiomyopathy in cardiomyocytes with short telomeres”. This research prize is awarded to early career scientists with the aim to encourage their research efforts. With this award, the DHKT promotes and recognizes the commitment of scientists in cardiovascular research. In principle, these research awards are intended to support ongoing scientific projects from the entire cardiovascular field from either basic or clinical research and innovation. MHH again funds the start of two innovative projects January 2024 IMTTS researchers Dr. Hannah Hunkler and Dr. Natalie Weber, PhD, each received a one-year grant from the MHH's "Hochschulinterne Leistungsförderung (HiLF)" program. The HiLF I program supports early career postdocs with a funding of 25,000 € to generate preliminary data for a successful application for third party funding. Dr. Hannah Hunkler was awarded funding for her project “Identifikation von potenten PROTACs zur spezifischen Degradierung von Rho Kinasen als Therapie von kardiovaskulären Erkrankungen” and Dr. Natalie Weber, PhD for her HiLF I project “Durch Mavacamten regulierte nicht-kodierende RNAs als neue therapeutische Optionen in Hypertropher Kardiomyopathie“. Congratulations to Katharina Hempel on the successful defense of her PhD thesis December 2023 Katharina Hempel has completed her doctoral thesis at the Leibniz University Hannover and at the IMTTS. She has successfully defended her PhD thesis entitled "New concept for the development of a thermal release strategy of active substances for gene therapy". Congratulations to Marida Sansonetti for successfully defending her PhD thesis December 2023 Marida Sansonetti has successfully defended her doctoral thesis entitled "Hypoxia-primed macrophages as therapeutic regulators of fibrosis in ischemic heart failure”. Exciting days of cardiovascular science at the CBFH Biennial Meeting in Naples November 2023 The biennial joint meeting of the ESC Working Groups on Cellular Biology of the Heart & Myocardial Function 2023 (CBFH) is a pivotal event in the cardiovascular research field. IMTTS members were thrilled to partake and present their research with oral and poster presentations. Prof. Thomas Thum and Prof. Christian Bär led insightful discussions and delivered exceptional presentations on the impact of the non-coding genome in cardiovascular disease and the importance of telomere biology in heart regeneration. Dr. Anne Bührke, Dr. Erika Hilbold, Dr. Hannah Hunkler, and Elisa Mohr gave excellent poster presentations and were engaged in discussions on the latest findings with experts in the field. Overall, the meeting presented cutting-edge research, clinical trials, and therapeutic developments and in addition, facilitated connections between the scientific community and biotechnology companies specializing in cardiovascular research. Professor Thomas Thum is one of the most highly cited researchers in the world for the fourth time in a row November 2023 "Clarivate Analytics" has released its latest findings on the world's most cited researchers 2023. These scientists have produced multiple highly cited papers that rank in the top 1% by citations for field and year in the Web of Science™ over the past decade. IMTTS Director Professor Dr. Dr. Thomas Thum is one of those scientists for the fourth consecutive year. This time he is listed in the category "Clinical Medicine". The current list of Highly Cited Researchers (https://clarivate.com/highly-cited-researchers/) includes 7,125 researchers from 23 disciplines in natural, life and social sciences. Congratulations to Sarah Cushman and Naisam Abbas for successfully defending their PhD theses November 2023 IMTTS scientists Sarah Cushman and Naisam Abbas were enrolled in the HBRS PhD program for Molecular Medicine and have both successfully defended their PhD theses this past November. Sarah’s thesis is entitled: "Investigating the role of a species-conserved circular RNA in cardiomyocyte proliferation and regeneration" and Naisam’s thesis was entitled: "Organomimetic living myocardial slices to study novel therapeutic entry routes for translational medicine". Congratulations! Prof. Dr. Christian Bär, Malte Juchem and Lea Oehlsen attended the 11th mRNA health conference in Berlin November 2023 Having a shared professorship with the Fraunhofer ITEM, Prof. Bär and his team are part of the lighthouse project RNAuto , which aims at the automated production of mRNA therapeutics. Within the cooperation of different Fraunhofer Institutes there is also a platform for the development of new RNA therapeutics (CIMD RNA Therapeutics). Therefore, the conference was a great inspiration and opportunity to explore the new highlights in the field of RNA therapeutics and their delivery. The conference was filled with excellent talks and the opportunities to meet with several leading researchers as well as industry business partners. During the conference, they had the great honor to meet the Nobel Laureate Katalin Kariko, who won the Nobel Prize in Physiology or Medicine this year for the discoveries concerning nucleoside base modifications that enabled the development of effective mRNA vaccines against COVID-19. Participation in the 30th European Society of Gene & Cell Therapy (ESGCT) 2023 October 2023 IMTTS scientists Dr. Anne Bührke and Anita Pralas proudly represented our FIBREX Team at the ESGCT in Brussels. As the ESGCT is a leading organization in the field of gene and cell therapy, we were excited to join this prestigious event and contribute to the exchange of knowledge and advancements in this rapidly evolving field. The conference brought together experts from various fields of study and demonstrated the translation of innovative research into clinical applications. It included many inspiring talks and panel discussions, which led to an overall fascinating experience. Especially during the Symposium from the European Innovation Council (EIC) Cell and Gene Therapy community, we gained a lot of new insights and perspectives. Congratulations to Dr. Erika Hilbold for successfully completing the TRAIN Academy's “Translational Research & Medicine” education program October 2023 For the past two years, IMTTS scientist Dr. Erika Hilbold has been trained in translational health research at the TRAIN Academy (Translational Alliance in Lower Saxony). The two-year career-oriented education program "Translational Research & Medicine: From Idea to Product" covered the individual steps of translational development, including product idea and quality assurance, the different product groups such as small molecules and biologics, and product development from pre-clinic to clinic and market. In addition, methodological and personal skills were promoted. Cardiology news at the DGK Herztage 2023 October 2023 IMTTS scientist Dr. Erika Hilbold and clinical researcher Dr. Anselm Derda attended the autumn meeting of the German Society of Cardiology (DGK) "Herztage 2023" in Bonn. Dr. Hilbold presented her work on long non-coding RNAs in neonatal cardiac regeneration at the Basic Science Meeting. Dr. Derda gave two lectures with tips and tricks for the young/future generation of cardiologists. Both enjoyed the news from the research field and the clinics. The participation of Dr. Erika Hilbold was supported by a travel grant from the DGK. Best Poster Award goes to Kevin Schmidt September 2023 IMTTS researcher Kevin Schmidt attended the D-A-CH Heart Failure Meeting in Göttingen. He received the best poster award in the basic research category for his work on cardioprotective effects of SGLT2 inhibitors in endothelial cells and cardiac fibroblasts. Exciting days at the 50th European Muscle Conference in Florence September 2023 Dr. Natalie Weber, PhD and Giuseppe Cipriano, a PhD student, attended the 50th European Muscle Conference (EMC) in Florence with two poster presentations. The EMC is an annual conference that brings together young scientists and senior experts to share the latest advances in muscle research, with topics ranging from basic research on muscle function to new disease models and drug development. This was a wonderful opportunity to learn and grow with experts and fellow scientists. “Joining forces to protect the heart” – the ESC congress 2023 in Amsterdam August 2023 Over 24,000 people were in attendance onsite for this year’s European Society of Cardiology (ESC) Conference in Amsterdam. We saw excellent basic science talks about RNA therapeutics for cardiovascular diseases where Professor Dr. Dr. Thomas Thum gave a riveting update on the progress of the first microRNA therapy for heart failure in patients to a completely packed lecture hall. Works outing August 2023 The Thum Lab had a very successful annual excursion. In addition to hard work and excellent science, creating a positive and healthy work environment is essential for maintaining a productive atmosphere. We would like to thank Professor Dr. Dr. Thomas Thum for making this day possible. New White Paper on Recommended Approaches for Nonclinical Pharmacokinetic Characterization of Therapeutic Oligonucleotides August 2023 The Absorption, Distribution, Metabolism, and Elimination (ADME) Subcommittee of the Oligonucleotide Safety Working Group has published recommendations for ADME characterization of oligonucleotide therapeutics in nonclinical studies. These recommendations can serve as a starting point for the design of nonclinical studies and as a basis for discussions with regulatory authorities. The publication can be found here: https://www.liebertpub.com/doi/10.1089/nat.2023.0011 Ellen Schmidt Program Supports Habilitation of Dr. Natalie Weber, PhD August 2023 We are pleased to announce that IMTTS scientist Dr. med. Natalie Weber, PhD, has been awarded a place in the Ellen Schmidt Program. This is a personnel support program that enables female scientists of all disciplines employed at the MHH to complete their habilitation by releasing them from routine activities. “Telomerase, eine Herzenssache!” July 2023 Professor Dr. Christian Bär gave his inaugural lecture at the Hannover Medical School on July 28th and highlighted his outstanding findings on the role of telomerase in cardiomyocytes. We look forward to the coming years in telomerase research. NextGENERATION Medical Scientist Program July 2023 IMTTS scientist Dr. med. Natalie Weber, PhD, has been accepted for one of six postdoctoral positions in the "Else Kröner Fresenius Stiftung" (EKFS) Medical Scientist Program nextGENERATION (ReGENERAte Organ FunctION), which offers advanced training in basic biomedical research with a clinically oriented, patient-centered focus. This 3-year structured scientific (and clinical) continuing education will allow her at least 20% research time for her own research project “Stammzell-basierte regenerative Therapien kardialer Erkrankungen” and 120,000 € in funding. Congratulations to Christopher Jahn for successfully defending his PhD thesis June 2023 IMTTS researcher Christopher Jahn was enrolled in the PhD-program “Molecular Medicine” and has successfully defended his PhD thesis “Investigation of the cellular Fabry disease phenotype using human iPSC-derived cardiomyocytes”. Best Poster prize at the Euromit 2023 for Dr. Shambhabi Chatterjee June 2023 Dr. Shambhabi Chatterjee attended the Euromit 2023 - International Meeting on Mitochondrial Pathology, 11-15 June 2023 in Bologna, Italy, where she presented a poster entitled "Telomerase is crucial for mitochondrial function in human cardiomyocytes" and was awarded the Best Poster prize (out of 564 abstracts) worth 550€. Her abstract was also selected for a flash talk presentation at the Young Investigators Meeting on 10 June 2023, co-organized by Mitocon & Euromit 2023. IMTTS was again well represented at the DGK’s annual conference April 2023 IMTTS scientists presented their work in 16 posters and talks at the annual meeting of the Deutsche Gesellschaft für Kardiologie – Herz- und Kreislaufforschung e.V. (DGK). Anita Pralas' poster was nominated for the DGK poster award. IMTTS researchers Sarah Cushman and Elisa Mohr were supported by travel grants from the DGK. Carla Borisch, Jonas Gruber, Kai Hillebrand and Laura Trumann received travel stipends from the Young DGK Section. CBCS Summer School in Nice June 2023 Organized by the European Society of Cardiology, the CBCS Summer School in Nice/Sophia Antipolis is a great opportunity for young scientists to gain in-depth knowledge in the field of basic cardiovascular science and to foster relationships between researchers across Europe. This year, Marco Bentele, Jia Li Ye and Laura Trumann had the amazing opportunity to participate in this event and to present and discuss their projects in a poster format with peers and experts. Jia Li Ye also had the honor to present her poster in an oral presentation. The five days were filled with impressive talks on targeted reprogramming of fibroblasts into cardiomyocytes, remote ischemic preconditioning, exosomes and many more cutting-edge topics in cardiovascular research. Collaborative Research Center on Heart Research (TRR267) extended for 4 years May 2023 For the past four years, IMTTS researchers and scientists from the Technical University of Munich (TUM), Goethe University Frankfurt, Ludwig-Maximilians-University Munich, Georg-Speyer-Haus Frankfurt, the Max Planck Institute for Heart and Lung Research in Bad Nauheim and Helmholtz Munich have been investigating the role of non-coding RNA in cardiovascular diseases as part of the German Research Foundation (DFG) Transregional Collaborative Research Center "Non-coding RNA in the Cardiovascular System" (TRR267). The DFG has now announced that the government funding has been extended for another four years. The additional funding will allow us to further investigate the identified target structures and establish this new class of compounds for cardiovascular therapeutics. We are looking forward to a challenging and interesting four years in non-coding RNA research. For more information, please click here: https://cardiovascular-ncrna.de/ 1st place Young Investigator Award at the HFA Congress for Dr. Sonja Groß May 2023 We are pleased to announce that Dr. Sonja Groß presented her groundbreaking work on AAV capsid engineering for cardiac fibroblast targeting in the Basic Science Young Investigator Award (YIA) Session at the Heart Failure World Congress 2023 in Prague. Her fantastic presentation was awarded with the 1st place Young Investigator Award in Basic Science, which is endowed with 1,000€. Non-coding genome advanced training May 2023 Professor Christian Bär spoke about the importance of translational RNA therapeutics in the heart between academia and industry at the international non-coding genome training program at the Institut Currie in Paris. An excellent training for PhD and Master students across Europe. Professor Dr. Christian Bär a nucleus member of AG13 and AG31 April 2023 Professor Dr. Christian Bär was elected as a nucleus member of the "Myocardial Function and Energetics (AG 13) - Basic Science Cluster" and "Cardiovascular Regeneration (AG 31) - Basic Science Cluster" working groups of the German Cardiac Society. Prestigious Guido Tarone Award for Dr. Sonja Groß March 2023 IMTTS members Prof. Dr. Dr. Thomas Thum, Prof. Dr. Christian Bär, Dr. Anne Bührke, Sarah Cushman, Naisam Abbas and Dr. Sonja Groß attended the Heart Failure Association (HFA) Winter Meeting on Translational Heart Failure Research in Les Diablerets, Switzerland. They engaged in insightful discussions about the latest advances in heart failure research. For her outstanding presentation on "Engineered adeno-associated viral vectors with an improved in vivo targeting of cardiac fibroblasts" in the keynote session, Dr. Sonja Groß received the Guido Tarone Award endowed with 1,500€. IMTTS researcher Kevin Schmidt receives poster prize March 2023 We are pleased to announce that Kevin Schmidt, a PhD student at IMTTS, received an award for his poster entitled "Molecular fingerprints of SGLT2 inhibitors in non-myocyte cardiovascular cell model" in the field of experimental and clinical pharmacology at the 8th German Pharm-Tox Summit in Ulm. HBRS prize for the best presentation goes to Carla Borisch March 2023 For her presentation entitled “Fabry disease modelling using patient-derived iPSCs and multicellular 3D heart organoids”, IMTTS researcher Carla Borisch won the prize for the best oral project presentation of the 1st year “Molecular Medicine” Ph.D. students during the annual retreat of the Hannover Biomedical Research School (HBRS). This accomplishment highlights the importance of her research, which centers on the establishment of a sophisticated in vitro model recapitulating the complex architecture of the human heart and allowing studying the cardiac phenotype of a rare disease such as Fabry disease. COVID-19, cardiovascular disease and physical activity - what do we know? March 2023 The COVID-19 pandemic has affected cardiovascular disease and physical activity in different ways. Cardiovascular complications are common in critically ill patients, but also occur in mild and asymptomatic COVID-19 cases. Long COVID has become a major public health concern, in part because of the high burden of cardiovascular symptoms. In addition, adequate levels of regular physical activity are critical for cardiovascular health, healthy body weight, and good mental health, and regular physical activity reduces the risk of severe COVID-19 outcomes. In this review, we provide an overview of the current status as well as future challenges and possible solutions. Find the publication here: https://pubmed.ncbi.nlm.nih.gov/36868374/ Please also see our video summary: https://www.sciencedirect.com/science/article/pii/S2095254623000194?via%3Dihub#sec0012 News about epigenetic therapies against cardiac fibrosis and remodeling in heart failure February 2023 In this review, the current knowledge on novel cellular and epigenetic therapies was summarized. Additionally, it was focused on two non-coding RNA-based strategies that reached the phase of early clinical development to counteract cardiac remodeling and heart failure. Moreover, the present status of the development of translating these novel therapies into clinical practice, limitations, and future perspectives were discussed. Please find the review here: https://pubmed.ncbi.nlm.nih.gov/36004821/ Close interactions between cancer and heart disease January 2023 Advances in cancer therapies have significantly improved the life expectancy of patients, but have also revealed previously unknown side effects. In particular, severe cardiotoxic side effects of widely used anticancer therapies limit their use and therefore compromise the success of the seemingly most appropriate treatments in large cancer patient cohorts. Conversely, cardiovascular disease can promote both the development and progression of several types of cancer, underscoring the close relationship between the two. These uniquely correlated diseases are being studied in the emerging field of cardio-oncology with increasing interest in non-coding RNAs. In our review, we focus on the new subtype of non-coding RNAs, circular RNAs, in their distinct exchange within cardio-oncology and discuss their suitability as potent targets for the simultaneous treatment of cardiac dysfunction and cancer. You can find the publication here: https://pubmed.ncbi.nlm.nih.gov/36651915 Professor Thomas Thum joined JCA as Consulting Editor January 2023 The Journal of Cardiovascular Aging (JCA) - an international peer-reviewed, open access, online journal – focuses on clinical, translational, and basic science discoveries regarding all aspects of aging and cardiovascular disease. Professor Thomas Thum joined the Journal as Consulting Editor in January 2023. His research interests are for example transcriptional control in cardiovascular biology by transcription factors and noncoding RNA molecules, development and treatment of heart failure, and diverse aspects in translational cardiovascular medicine, including large animal and early clinical trial studies. MHH funds the beginning of two innovative projects January 2023 IMTTS researchers Dr. Shambhabi Chatterjee and Dr. Franziska Kenneweg were each awarded a one-year grant from the Hannover Medical School's (MHH) "Hochschulinterne Leistungsförderung (HiLF)" program. Dr. Shambhbai Chatterjee received 25,000 € funding for her HiLF I project “Deciphering the metabolic changes underlying the cardioprotection of telomerase therapy in human cardiomyocytes” and Dr. Franziska Kenneweg received 25,000 € funding for her HiLF I project “Entwicklung von herzspezifischen Nanopartikel-basierten Transportvehikeln von ncRNA-Therapeutika“. The HiLF program supports early career postdocs (HiLF I) with an initial funding allowing the scientist to generate preliminary data for a successful application for external third party funding. Congratulations to Christian Bär – our new Professor of Cardiac Regeneration January 2023 Professor Dr. Christian Bär started as principal investigator and group leader at the IMTTS in 2015 investigating cardiac aging and regeneration. In 2021, he habilitated in the field of experimental and regenerative cardiology. Since January 2023, he holds a professorship for Cardiac Regeneration at MHH and Fraunhofer ITEM. This shared professorship enables the unique opportunity to combine basic science with applied research. Congratulations to Hannah Hunkler for successfully defending her PhD thesis December 2022 IMTTS scientist Hannah Hunkler has successfully defended her PhD thesis entitled “Functional and molecular investigation of the long non-coding RNA Cyrano in cardiac regeneration”. News about heart failure with preserved ejection fraction (HFpEF) November 2022 Professor Dr. Dr. Thomas Thum, PD Dr. Christian Bär and Hannah Hunkler contributed to the first SFB1470 retreat in Berlin. They presented new discoveries on the role of circular RNAs in HFpEF. Please find out more about this interesting topic, here: https://sfb1470.charite.de/ Prof. Thomas Thum is one of the Highly Cited Researchers for the third time November 2022 The company “Clarivate Analytics” annually analyzes scientific publications and identifies the worlds most cited researchers. These scientists have produced multiple highly cited papers that rank in the top 1% by citations for field and year in the Web of Science™. IMTTS director Professor Thum is among these researchers for the third successive time. He is listed in the “Cross-Field” category, which means that these researchers have an impact on various science topics, not only within their actual field of work. The current list of Highly Cited Researchers (https://hcr.clarivate.com/) contains about 6,938 researchers from 23 disciplines in the natural, life and social sciences. Thereof, 369 scientists work in Germany and three – Prof. Dr. Dr. Thomas Thum, Prof. Dr. Michael Manns and Prof. Dr. Thomas Werfel – at the Hannover Medical School. Dr. Shambhabi Chatterjee receives Young Investigator Award November 2022 IMTTS researchers Naisam Abbas, Dr. Anne Bührke, Dr. Shambhabi Chatterjee, Giuseppe Cipriano and Dr. Mira Jung as well as principle investigators Dr. Natalie Weber, PhD and PD Dr. Christian Bär participated in the second international KFO311-Symposium „Cardiac and pulmonary failure: mechanical unloading and repair“ in Hannover. For her research work, which investigates the role of telomerase during differentiation of induced pluripotent stem cells into cardiomyocyte, Dr. Shambhabi Chatterjee was honored with the Young Investigator Award. Congratulations to Sonja Groß and Dimyana Neufeldt for successfully defending their PhD theses November 2022 IMTTS researcher Sonja Groß has successfully defended her PhD thesis entitled “Generation of cardiac fibroblast-specific AAV vectors for the cell type-specific delivery of non-coding RNAs” within the PhD program “Molecular Medicine”. Moreover, IMTTS scientist Dimyana Neufeldt was also enrolled in the PhD program “Molecular Medicine” and has successfully defended her PhD thesis “Characterization of circular RNA circZFPM2 as therapeutic target in hypertrophic cardiomyopathy”. “Classical and Novel Biomarkers and Omics in Cardiovascular Disease – Driving Toward More Medical Value” October 2022 Professor Thomas Thum and PD Dr. Christian Bär discussed the future of diagnostic, prognostic and risk stratification biomarkers in cardiovascular diseases at the 17th Annual Meeting of the Transatlantic Heart Failure Biomarker Working Group in Cannes, France. Exciting breakthroughs and innovations in organoids, spheroids and stem cells October 2022 PD Dr. Christian Bär and our PhD-student Elisa Mohr attended the International Forum on cell manufacturing and engineering, CellME, in Berlin. Here, scientists, engineers and business delegates were brought together highlighting innovations and exciting breakthroughs in the field of 2D and 3D cell manufacturing technologies, gene- and cell-based therapies. In addition, an exhibition provided the possibility to see the latest technologies in this important field. RNA leaders USA conference October 2022 Professor Thomas Thum was presenting how non-coding RNA-based therapeutics can trigger a paradigm shift in treating heart diseases at the RNA Leader’s Conference in Boston. This conference provides latest advances in RNA chemistry and clinical updates from the companies developing new therapies. Thus, Professor Thum enjoyed great discussions and talks in the field of RNA therapeutics. TRR267 galaxy workshop meeting October 2022 Sarah Cushman and Dr. Dongchoa Lu met up with SFB partner for an interactive two-day workshop in Frankfurt. They were trained in analyzing RNA-seq and ChIP-seq data. INNOVATION in cardiac regeneration October 2022 PD Dr. Christian Bär and Dr. Erika Hilbold participated in the “INNOVATION in Cardiac Regeneration Symposium” in Aveiro, Portugal. This symposium brought together researchers, students and health professionals to discuss innovative strategies for heart repair using biomedical multi-disciplinary approaches. Besides, the consortium of INNOVATION - a funded project by the European Research Area Network on Cardiovascular Diseases (ERA-CVD) and coordinated by PD Dr. Christian Bär - met and discussed the newest findings in the world of long non-coding RNAs and cardiac regeneration. Dr. Dongchao Lu receives prestigious Helmut-Drexler Publication Prize September 2022 The Helmut-Drexler Publication Prize was awarded to IMTTS researcher Dr. Dongchao Lu for his outstanding work entitled „A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity“ in the field of myocardial function and energetic at the “Herztage 2022” of the German Cardiac Society (DGK) in Bonn. The Helmut Drexler Publication Prize aims to promote young scientists in the field of basic cardiovascular research and is endowed with 3000€. DGK funds two IMTTS research projects September 2022 IMTTS researcher Dr. Dongchao Lu received a 50,000 € grant for the research project “Recombinant circRNA mediated therapy for cardiotoxicity in cardiomyocytes” funded by the German Society of Cardiology-Cardiovascular Research e.V. (DGK) for a period of one year. The project aims to test the potential of recombinant Circ-INSR as an RNA-based therapy for the prevention of doxorubicin-induced cardiotoxicity. In addition, IMTTS scientist Dr. med. Natalie Weber, PhD also received a 50,000 € grant for her research project “Non-coding RNA therapies in hypertrophic cardiomyopathy” funded by the DGK for a period of one year. This project aims to identify and modulate non-coding RNAs, which can regulate contractility in cardiomyocytes and myocardial tissue from patients with hypertrophic cardiomyopathy. ERA-CVD symposium Riga September 2022 The second ERA-Net on Cardiovascular Diseases (ERA-CVD) Symposium was held in Riga, Lativa. IMTTS’s principal investigator PD Dr. Christian Bär gave insights on lncRNAs regulating cardiac regeneration and had the chance to network globally with innovative scientists. Excellent days at the German stem cell network (GSCN) annual meeting September 2022 Elisa Mohr, Hannah Hunkler and Christopher Jahn had the opportunity to present and discuss their stem-cell based work in a poster format at the GSCN annual meeting 2022 in Münster. Four days were filled with great talks about stem cell biology, cell therapies in diverse diseases, organoid platforms and much more, complemented by industry talks and exhibition. A central highlight was the talk of Nobel Prize winner and stem cell research A-lister Shinya Yamanaka with his inspiring take-home message that you always should dream big, work hard and believe in yourself. Sonja Groß participated in the first ESGCT Academy September 2022 This summer, the European Society of Gene & Cell Therapy (ESGCT) launched a new initiative – The ESGCT Academy. PhD-student Sonja Groß had the very exciting chance to both participate and present her work at the ESGCT Academy in San Sebastian, Spain. This was a wonderful opportunity to learn and grow with experts and fellow scientists. Cardior opens new headquarters September 2022 In an official ribbon cutting ceremony with Dr. Bernd Althusmann, Deputy Prime Minister of Lower Saxony and Minister of Economic Affairs, Labour, Transportation and Digitization IMTTS spin-off Cardior Pharmaceuticals opened their new headquarters in the science park Marienwerder (Hollerithallee 20, 30419 Hanover). The Pharma-Oscar goes to Cardior Pharmaceuticals September 2022 Cardior Pharmaceuticals received the Pharma Trend Image & Innovation Award. Their lead candidate CDR132L has been recognized as “Das Innovativste Produkt® 2022” in the category “Sprunginnovationen”. CDR123L is a synthetic antisense oligonucleotide and a selective inhibitor of microRNA-132-3p (miR-132). miR-132 expression is associated with pathological cardiac remodeling and heart failure. Basic investigations of mir-132 and the preclinical development of a miR-132 inhibitor for heart failure treatment have been performed at the IMTTS. Thereafter, IMTTS spin-off Cardior Pharmaceuticals took care of CDR123L’s translational development and meanwhile the efficacy and safety of CDR132L will be assessed in patients with reduced left ventricular ejection fraction (≤ 45%) after myocardial infarction in a multicenter, randomized, parallel, 3-arm, placebo-controlled phase 2 study (NCT05350969). Work outing 2022 August 2022 The Thum lab had a very successful annual work outing. In addition to hard work and excellent science, a happy and healthy work environment is essential for productivity! Many thanks to Professor Dr. Dr. Thomas Thum for making this day possible! IMTTS joined the ESC Congress 2022 in Barcelona August 2022 IMTTS members spent great days hearing many inspiring talks at the ESC (European Society of Cardiology) Congress in Barcelona. They had nice conversations with key opinion leaders from around the world. Moreover, IMTTS took part in a great session and panel discussion about current and future perspectives of RNA therapeutics. Professor Thum and IMTTS team received prestigious Desmond Julian Award August 2022 Professor Dr. Dr. Thomas Thum and IMTTS team were awarded for their paper “Novel antisense therapy targeting microRNA-132 in patients with heart failure: results of a first-in-human Phase 1b randomized, double-blind, placebo-controlled study” during the Annual Meeting of the European Society of Cardiology. The Desmond Julian Award is an initiative of the European Heart Journal. This annual prize recognizes one outstanding original paper published in the European Heart Journal during the previous year. Editor-in-Chief and the Executive Editors judge the papers on originality, methodology, presentation, and importance, also utilizing accepted bibliometric indexes. Furthermore, this award also commends the team in which the first author is working. Please find the original publication here: https://pubmed.ncbi.nlm.nih.gov/33245749/ Further information on the 2022 Desmond Julian Award can be found here: https://doi.org/10.1093/eurheartj/ehac557 “We can still expect a lot there” – an Interview about RNA science and therapies August 2022 The Federal Agency for Civic Education (Bundeszentrale für politische Bildung/bpb) regularly publishes information on political issues for everyone. "Aus Politik und Zeitgeschichte (APuZ)" is one of the bps‘s magazines, which is published online and as supplement of the newspaper “Das Parlament”. In the recent issue “Gentechnik”, Professor Thomas Thum gave an interview about RNA, the current RNA research fields and therapeutic possibilities using RNA. With regard to the latter, RNA therapeutics against cancer, rare diseases and heart failure need to be mentioned. Professor Thum and his team focus on developing RNA therapeutics against heart failure. The first candidate, microRNA-132, has successfully passed the first phase of clinical trials and undergoes the second phase, now. Another candidate, a circular RNA, has been identified, which plays an important role in regulating chemotherapy-mediated cardiotoxicity. Professor Thum believes that “we can still expect a lot” regarding RNA therapeutic strategies. Please find the whole interview here: "Wir dürfen da noch sehr viel erwarten" | bpb.de The Thum Lab has officially joined Twitter August 2022 Updates on our most recent publications, talks, and lab activities in the cardiology and RNA world can be found on Twitter @Thum_Lab, now. Accelerating cardiovascular research: recent advances in translational 2D and 3D heart models July 2022 As the prevalence of cardiovascular diseases increases, so does the need for sufficient in vitro systems that recapitulate the complex human heart. Our recent review, first-authored by IMTTS researcher Elisa Mohr and published in the “European Journal of Heart Failure”, therefore summarizes the basic principles of cardiomyocyte monolayer cultivation as well as the 3D culture systems of cardiac spheroids and organoids, engineered cardiac microtissues, bioprinted cardiac tissues and ex vivo living myocardial slices. In addition, we highlighted latest advances of these heart models that aim to bridge the gap of in vitro and in vivo systems. Please find our review here: https://onlinelibrary.wiley.com/doi/10.1002/ejhf.2631 Nature Review Cardiology highlights IMTTS’ publication July 2022 We are glad that Nature Review Cardiology selected our recently published article about circular RNAs as novel therapeutic strategy against doxorubicin-induced cardiotoxicity as a research highlight. Please find their comment here: Circular RNA prevents doxorubicin-induced cardiotoxicity | Nature Reviews Cardiology Original article: Lu D, Chatterjee S, Xiao K, et al . A circular RNA derived from the insulin receptor locus protects against doxorubicin-induced cardiotoxicity [published online ahead of print, 2022 Jun 27]. Eur Heart J . 2022;ehac337. doi:10.1093/eurheartj/ehac337, see: https://pubmed.ncbi.nlm.nih.gov/35758064/ News about targets in heart failure treatment July 2022 IMTTS researchers Sonja Groß, Malte Juchem, Jia Li Ye, Kevin Schmidt, Florian Waleczek, Dr. Shambhabi Chatterjee and PD Dr. Christian Bär attended the DGK symposium ‘Targets in heart failure treatment’ in Würzburg organized by AG12 and AG13 of the DGK working groups from 15-16th July 2022. The sessions covered topics in basic, translational and clinical aspects. IMTTS researchers also presented their innovative research during the poster session. New AAV vectors for cardiac-directed gene therapy July 2022 AAV vectors are promising delivery tools for human gene therapy. However, broad tissue tropism and pre-existing immunity against natural serotypes limit their clinical use. By in vivo AAV2 peptide display library screening in a murine model of pressure overload-induced cardiac hypertrophy, IMTTS researchers Dr. Laura Rode and PD Dr. Christian Bär have identified two promising AAV capsid variants in collaboration with Prof. Dr. Hildegard Büning. The newly identified AAV vectors are auspicious novel tools for cardiac-directed gene therapy outcompeting the reference serotype AAV9 regarding the specificity and therapeutic efficiency of in vivo cardiomyocyte transduction. Please find out more in the original article: https://doi.org/10.1016/j.ymthe.2022.07.003 In addition, please have a look on the website of MHH Insight: https://www.mhh.de/en/presse/mhh-insight/news-detailed-view/targeting-heart-disease# Circular RNA therapy against doxorubicin-induced cardiotoxicity June 2022 Noncoding RNA based therapy has gained a lot of focus as a potential treatment strategy for cardiovascular diseases. In another recent publication, IMTTS scientists have identified a highly species conserved circular RNA (Circ-RNA) which plays important role in regulating doxorubicin-mediated cardiotoxicity. Dr. Dongchao Lu and Dr. Shambhabi Chatterjee led this project under the supervision of Prof. Dr. Dr. Thomas Thum and PD Dr. Christian Bär. After performing a Circ-RNA sequencing, the team came across Circ-INSR as a potential regulator of heart failure. Using animal models in vivo and a translational human induced pluripotent stem cell derived cardiomyocyte (hiPSC-CM) model in vitro , gain and loss-of-function studies for Circ-INSR were performed in the context of doxorubicin-induced heart failure. Using adeno-associated viruses (AAVs), the researchers validated that Circ-INSR overexpression exhibits protective effects against doxorubicin-induced cardiotoxicity via modulating mitochondrial function. Furthermore, these protective effects were reproducible with another novel strategy of Circ-RNA overexpression. The IMTTS research team generated the Circ-INSR mimics with the help of in vitro transcription techniques and applied an innovative circularization technology to produce these molecules for pre-clinical tests. With this publication, we not only provide a better mechanistic understanding of the Circ-RNA mechanisms but also a novel strategy to overexpress Circ-RNAs for therapeutic options. Please find the publication here: https://pubmed.ncbi.nlm.nih.gov/35758064/ Congratulations to Anne Bührke and Alessia Costa for successfully defending their PhD theses June 2022 IMTTS researcher Anne Bührke has successfully defended her PhD thesis entitled “Long noncoding RNAs H19 and Meg3 as therapeutic targets in cardiac diseases” within the PhD program “Molecular Medicine”. Moreover, IMTTS scientist Alessia Costa was enrolled in the PhD program “Regenerative Sciences” and has successfully defended her PhD thesis “Establishment of a human reporter cell line for the identification of cardiac regenerative targets”. New in silico approach for transcription factor regulation screening June 2022 Analyzing regulatory elements of hypoxia-sensitive genes in silico predicted the transcription factors SP1 and KLF5 as potential orchestrators in human endothelial hypoxic gene expression. Further studies revealed that these transcription factors also modulate angiogenesis by regulating proliferation and tube formation of endothelial cells. In summary, an intuitive in silico approach to screen for transcription factor regulation, allowing the modeling of significant biological processes including, but not limited to, hypoxia has been developed. Such approach is a valuable tool to support RNA-based therapeutic interventions in transition to clinical stage. The study was led by IMTTS researcher Arne Schmidt in collaboration with Maximilian Fuchs from the Department of Bioinformatics at the University of Würzburg under the supervision of PD Dr. Jan Fiedler, Prof. Dr. Dr. Thomas Thum and Dr. Meik Kunz. Their work entitled “Deciphering Pro-angiogenic Transcription Factor Profiles in Hypoxic Human Endothelial Cells by Combined Bioinformatics and in vitro Modeling” was published in in the journal “Frontiers in Cardiovascular Research”. Please find the original article here: https://www.frontiersin.org/articles/10.3389/fcvm.2022.877450/full Berlin was calling June 2022 The 24th World Congress for the International Society for Heart Research (ISHR) took place this year in Berlin in mid-June. More than 650 participants attended with over 125 lectures, three of which, were given by institute director Prof. Dr. Dr. Thomas Thum entitled: “ CircRNAs as new therapeutic targets in HFpEF”, “MicroRNAs targeting the SARS-CoV-2 entry receptor ACE2 in cardiomyocytes”, and “ncRNAs-based therapeutic approaches in HF”. IMTTS researchers: PD Dr. Christian Bär, Sarah Cushman, and Marida Sansonetti were also in attendance with posters in the following sessions: “Regeneration, Re-engineering & stem cells” and “Dysfunction, inflammation and contractile proteins." DFG grant for investigating senescence in pulmonary and cardiac diseases May 2022 IMTTS’s principal investigator PD Dr. Christian Bär and Professor Christina Brandenberger (Institute of Functional Anatomy, Charité Berlin) received a 500,000 € grant for the research project “Targeting telomere dysfunction-related immune- and organ senescence in pulmonary and cardiovascular disease” funded by the German Research Foundation (Deutsche Forschungsgemeinschaft, DFG) for a period of three years. The project aims to untangle both mechanisms and interactions of the heart-lung axis in acute lung injury and myocardial infarction as well as to study telomere dysfunction-associated related senescence of the immune system, of heart and lungs. Hence, the ultimate goal of these studies will be to improve age-related regeneration and survival in both diseases. Neonatal injury models to study heart regeneration May 2022 Our recent review, published in Basic Research in Cardiology, provides a comprehensive overview of neonatal cardiac injury mouse models, which are widely used for the identification of molecular targets with pro-proliferative potential. These models are essential for understanding and investigating the regenerative potential of mammalian heart. Here we have briefly summarized well-known factors that may stimulate heart regeneration by inducing endogenous cardiomyocyte proliferation in mammals. Further, we highlight the findings emerged in large animal models and in human newborns, which pave the way for promising translational therapies for cardiac regeneration. Please find the review here: https://link.springer.com/article/10.1007/s00395-022-00931-w IMTTS Director Professor Thum was awarded a prestigious ERC Advanced Grant by the European Research Council (ERC) May 2022 Heart failure is one of the most common causes of death worldwide. In Germany, around four million people suffer from cardiac insufficiency. Besides others, remodeling processes in the heart muscle lead to this disease. These processes, inter alia, can be triggered by side effects of chemotherapy. So far, there is no treatment option that can stop or even reverse the course of the disease. Professor Dr. Dr. Thomas Thum and his team are now looking for such a strategy within the research project REVERSE. The focus will be on so-called circular RNAs (circRNA), which belong to the group of non-coding RNAs (ncRNA). "Within the family of ncRNAs, circRNAs are particularly stable and species-conserved, i.e. largely unchanged in the course of evolution," explains Professor Thum. "This makes them ideal targets for drugs." As first step, a circRNA library will be screened for suitable candidates which will be challenging as, so far, approximately 20,000 to 30,000 different circRNAs have been identified but only for around ten of those their mode of action has been ascertained. Thereafter, IMTTS researchers want to check whether the selected RNA structures actually control the cardiac remodeling in the case of heart damage caused by chemotherapy or other triggers fostering apoptosis in the heart. For this approach, the scientists will use living myocardial slices. In the following, it will be investigated how cardiotoxicity can be stopped. Please find more information about this important topic in the entire article: https://www.mhh.de/en/presse/mhh-insight/startseite-news-detailed-view/mhh-researcher-wants-to-stop-harmful-effect-of-chemotherapy-on-heart-muscle IMTTS receives 2.5 million euros from the European Innovation Council (EIC) to further develop an anti-fibrotic cardiac RNA drug (FIBREX project) April 2022 Professor Dr. Dr. Thomas Thum and IMTTS researchers discovered a specific long non-coding RNA, which is named Meg3 and is crucial for controlling fibrosis formation in heart failure, in the past. Within the scope of the FIBREX project, the developed Meg3 inhibitor will be further tested in animal models for efficacy safety in order to reach clinical maturity. For this phase of drug development, it is usually very difficult to get the necessary financial support. However, the new EU innovation funding line closes this gap, now. Thus, Professor Thum and his team are confident that they will further develop their patented Meg3 inhibitor into an effective fibrosis drug that will drastically revolutionize medical practice, reduce healthcare costs and, last but not least, significantly improve patients' lives. Please find more information about this important topic in the entire article: https://www.mhh.de/en/presse/mhh-insight/startseite-news-detailed-view/mhh-on-the-home-stretch-to-the-rna-drug-against-cardiac-fibrosis IMTTS researcher Sarah Cushman receives DGK poster prize April 2022 Sarah Cushman, a PhD student at IMTTS was awarded the prestigious poster prize from the German Cardiac Society (DGK) at the society’s annual conference in Mannheim for her poster entitled “Insights into the role of circular RNA, circREGEN, in cardiomyocyte proliferation and cardiac regeneration”, which was selected out of hundreds of posters. This poster delves into the role by which circREGEN influences the regenerative potential of the heart, as well as the protective effect it offers against stress inducing factors. IMTTS is well represented at the DGK’s annual conference April 2022 IMTTS director Professor Dr. Dr. Thomas Thum and IMTTS researchers Naisam Abbas, Dr. Dongchao Lu, Sonja Groß, Hannah Hunkler, Arne Schmidt, Dr. Mira Jung, Sarah Cushman, Marida Sansonetti, Alessia Costa, Wen Pan, Dr. Christian Bär, Dr. Shambhabi Chatterjee, Dimyana Neufeld, Dr. Anselm Derda, Kevin Schmidt, Christopher Jahn and Jan Weusthoff attended the 88th annual meeting of the DGK (German Society of Cardiology) in Mannheim and presented their work on molecular therapies (ncRNA, small molecules) of heart failure. The attendance of IMTTS researchers Sonja Groß, Hannah Hunkler, Sarah Cushman, Dimyana Neufeld, Kevin Schmidt, Christopher Jahn and Jan Weusthoff was supported by travel grants from the DGK. Naisam Abbas, Marco Bentele, Elisa Mohr, Sinje Biß, Malte Juchem, Lili Ye and Anabel Lambrecht received travel stipends from the Young DGK Section. The Best Poster Award goes to Dr. Shambhabi Chatterjee at Dutch-German Joint Meeting March 2022 IMTTS researcher Dr. Shambhabi Chatterjee received the best poster award at the 19th Dutch-German Joint Meeting of the Molecular Cardiology Working Groups including a cash prize of 100€. She had presented her poster entitled “Telomerase is essential for differentiation of human iPSCs into cardiomyocytes”. Dr. Chatterjee’s research highlights the importance of the telomerase enzyme for the development and survival of cardiomyocytes since the absence of telomerase and shorter telomere lengths result in poor differentiation efficiency and higher susceptibility to cell death. This research work also established an elegant in vitro model where telomerase activity and telomere lengths can be modulated at will. Hence, this research work also helped to generate a platform with high potential for drug screening and pre-clinical testing for future research investigations. IMTTS receives funding of 500,000€ from Lower Saxony for Long COVID studies March 2022 As around ten to fifteen percent of all SARS-CoV-2 infected people suffer from late effects of COVID‑19, and a mild or asymptomatic infection seemingly does not protect against this, it is of great interest to investigate causes of Long COVID and to develop treatment options. With COFONI (COVID‑19-Forschungsnetzwerk Niedersachsen), the state of Lower Saxony has created a cross-disciplinary research network that aims to combat the long-term consequences of the pandemic. Within the scope of Lower Saxony‘s COVID-19 research network, the state is providing 5.97 million euros for thirteen interdisciplinary projects. There is special support only for four research projects focusing on Long COVID using special funds, thus, enabling an immediate commencement of the study. One of these research projects will be carried out by IMTTS researchers. The study will investigate the role of circular RNAs as mediators of SARS‑CoV‑2 infections in the cardiovascular system. Initial cell culture experiments have shown that manipulation of certain circular RNAs can potentially inhibit SARS-CoV-2 infection in cardiomyocytes. IMTTS researchers will work together with TWINCORE scientists (Centre for Experimental and Clinical Infection Research) to explore further the therapeutic application of specific circular RNA candidates for COVID-19. Please find more information on COFONI here: https://www.umg.eu/forschung/corona-forschung/cofoni/ New natural compound similar with anti-fibrotic properties in humans March 2022 Activated cardiac fibroblasts – the major cell type of human and murine hearts – contribute to an excessive deposition of extracellular matrix (ECM) leading to cardiac fibrosis and subsequently organ dysfunction. Except the pulmonary drugs, nintedanib and pirfenidone, therapeutics specifically targeting anti-fibrotic pathways are rare. By screening large libraries of natural occurring compounds, first lead structures lycorine and bufaline with anti-fibrotic properties in vitro and in vivo were previously identified. To improve efficacy of these anti-fibrotic lead structures in vitro validation studies and in silico prediction were combined. Additionally, large OMICs-multi-panel-based mechanistic studies were performed. Twenty-six similars of the initially identified anti-fibrotic lead molecules bufalin and lycorine were analyzed in human cardiac fibroblasts (HCF) and their anti-proliferative activity and potential toxicity were determined in an array of in vitro and ex vivo studies. Noteworthy, certain similars were more effective at inhibiting HCF proliferation than nintedanib and pirfenidone, even at a lower concentration. Furthermore, low cytotoxicity on human iPS-derived cardiomyocytes and anti-fibrotic gene regulation in human ex vivo living myocardial slices were found for selected similars. Moreover, array and RNA sequencing studies of coding and non-coding RNAs in treated HCFs revealed strong anti-fibrotic properties, especially with the lycorine similar lyco-s (also known as homoharringtonine), that led to a nearly complete shutdown of ECM production at concentrations 100-fold lower than the previously identified anti-fibrotic compound lycorine without inducing cellular toxicity. In summary, a new natural compound similar with strong anti-fibrotic properties in human cardiac fibroblasts and human living heart tissue was identified which potentially opens new anti-fibrotic treatment strategies. Please find the publication here: https://doi.org/10.1007/s00395-022-00919-6 IMTTS Director Professor Thomas Thum is a new Member of Lower Saxony’s Life Science-Startup-Board February 2022 The Life Science-Startup-Board of Lower Saxony was founded after the first Life Science Startup Day in 2020. At that time, experts of different fields, such as life science and politics, have recognized the great potential of Lower Saxony’s scientific landscape. By founding the Life Science-Startup-Board they laid the foundation for expanding and strengthening the ecosystem of Life Science-Startups in Lower Saxony. Additionally, they aim to improve its attractiveness. In particular, the first two work priorities are elaborating potential solutions for more transparency, rapidness and startup friendliness especially with regard to IP based spin-offs and working on the initiative RAPID – Response Against Pandemic Infectious Diseases. The latter will allow a greatly accelerated and early development of new and safe drugs and therapeutics against future pandemic infectious diseases. For these approaches, an interdisciplinary team is necessary. Thus, the Life Science-Startup-Board 2022 is chaired by Dr. Sabine Johannsen, state secretary of Lower Saxony‘s Ministry of Science and Culture, and Stefan Muhle, state secretary of the Ministry of Economics, Labor, Transport and Digitization of Lower Saxony and furthermore, consists of six scientists and founders. One of those is the director of IMTTS and Fraunhofer ITEM as well as founder of Cardior Pharmaceuticals GmbH Professor Dr. Dr. Thomas Thum. Please find out more about Lower Saxony’s Life Science-Startup Board here: https://startup.nds.de/expertinnengremium-niedersaechsische-life-science-startup/ MicroRNA therapeutics in cardiac ischemia/reperfusion (I/R) injury January 2022 RNA therapy is the novel gene therapy for cardiac vascular diseases. IMTTS scientists observed that miR-486 protects against cardiac I/R injury and myocardial apoptosis through targeting PTEN and FoxO1 as well as activation of the AKT/mTOR pathway. Overexpression of miR‑486 might be a promising therapeutic strategy for myocardial protection. Please find the publication here: https://pubmed.ncbi.nlm.nih.gov/35077859/ Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. January 2022 Consensus document of the European Society of Cardiology (ESC) Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart Cardiovascular diseases represent a major cause of morbidity and mortality, necessitating research to improve diagnostics, and to discover as well as test novel preventive and curative therapies. All of which warrant experimental models that recapitulate human disease. The translation of basic science results to clinical practice is a challenging task. In particular, for complex conditions such as cardiovascular diseases, which often result from multiple risk factors and co-morbidities. This consensus document highlights recent advances in trying to reduce the number of animals for cardiovascular research. These models range from stem cell-derived models to in situ modelling of heart properties, bioinformatic models based on large datasets, and improved current animal models, which show clinically relevant characteristics observed in patients with a cardiovascular disease. Hereby, the aim is to provide a guide to help researchers in their experimental design to translate bench findings to clinical routine taking the replacement, reduction and refinement (3R) as a guiding concept. Please find the new position paper by the ESC here: https://doi.org/10.1093/cvr/cvab370 IMTTS is a Collaborator of the DFG Collaborative Research Center 1470 January 2022 The German Research Foundation (DFG) provides initial funding of € 12 million for a period of four years for a new Collaborative Research Center (CRC) led by Charité to study the underlying mechanisms of a specific type of heart failure – known as “heart failure with preserved ejection fraction” (HfpEF) – and to develop targeted treatments. Hannover Medical School is one of the CRC 1470 collaborators. IMTTS will be responsible for the project “Mechanisms, therapeutics and diagnostic potential of circular RNAs in HfpEF”. Within this project, the researchers will focus on three specific, interconnected work packages. The overall goal of these is to investigate how circular RNAs are mechanistically involved in cardiac remodeling and diastolic dysfunction. “We have established and published relevant methods for cardiac phenotyping, RNA sequencing and analysis,” says Prof. Dr. Dr. Thomas Thum. Furthermore, he clarifies: “Specifically, we aim (1) to improve our understanding about the function and potential therapeutic modulation using in vitro and ex vivo models of HFpEF, (2) to establish a new cell‑type specific circRNA-based therapeutic approach of HFpEF and (3) to test whether selected circulating noncoding RNAs can serve as stratification markers in various cohorts of patients with HFpEF. The ambition and vision of this project is to develop a next generation therapeutic approach for HFpEF patients within the first funding period of the CRC and beyond.” Please find more information on the official website: DFG Sonderforschungsbereich 1470 - DFG Collaborative Research Centre 1470 (charite.de)

laparoscopic liver resection study group investigators. Defining Global Benchmarks for Robotic Liver Resections: An International Multicenter Study. Ann Surg. 2025 Jul 25. doi: 10.1097/SLA.0000000000006852

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Publikationen mit Unterstützung durch das Sorter-Labor (Auswahl) 2026 B cell hyperactivation in an Ackr4-deficient mouse strain is not caused by lack of ACKR4 expression. Eckert N, Werth K, Willenzon S, Tan L, Förster R. J Leukoc Biol. 2020 Jun;107(6):1155-1166. doi: 10.1002/JLB.2MA1119-300R. Epub 2019 Dec 16. PMID: 31841228 Ex vivo long-term expansion of human hematopoietic stem and progenitor cells as a tool for modeling vector integration sites and clonality. Fleischauer J, John-Neek P, Ha TC, Mansel F, Kosanke M, Selich A, Hagedorn M, Bastone AL, Schinke M, Dziadek V, Dittrich-Breiholz O, von Kaisenberg C, Schambach A, Rothe M. J Transl Med. 2026 Feb 7;24(1):384. doi: 10.1186/s12967-026-07700-6. PMID: 41654907 Free PMC article. Differentiation-induced reduction in functional diversity restricts the ability of cytomegalovirus-specific CD8 T cells to eliminate virus-infected cells. 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No abstract available. 2025 Targeting BCL11B in CAR-engineered lymphoid progenitors drives NK-like cell development with prolonged anti-leukemic activity. Baatz F, Ghosh A, Herbst J, Polten S, Meyer J, Rhiel M, Maetzig T, Geffers R, Rothe M, Bastone AL, John-Neek P, Frühauf J, Eiz-Vesper B, Bonifacius A, Falk CS, Kaisenberg CV, Cathomen T, Schambach A, van den Brink MRM, Hust M, Sauer MG. Mol Ther. 2025 Apr 2;33(4):1584-1607. doi: 10.1016/j.ymthe.2025.02.024. Epub 2025 Feb 15. PMID: 39955618 Free PMC article. LMP2A-Targeting CAR-T Cells Equipped With Inducible IL-18 to Address EBV-Associated Malignancies. Dragon AC, Thoelke S, Mausberg P, Zimmermann K, Blasczyk R, Hudecek M, Abken H, Schambach A, Maecker-Kolhoff B, Eiz-Vesper B. HLA. 2025 Oct;106(4):e70439. doi: 10.1111/tan.70439. PMID: 41116979 Free PMC article. PAM-interacting domain turn-helix 51 motifs can improve Cas9-SpRY activity. 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Veranstaltungen REBIRTH Kolloquium Seit vielen Jahren wird über regelmäßige Vortragsveranstaltungen des Forschungszentrums für translationale regenerative Medizin REBIRTH („From Regenerative Biology to Reconstructive Therapy“) der wissenschaftliche Austausch rund um das Themenfeld regenerativer Therapien gefördert. Das REBIRTH Kolloquium findet in der Regel jeden Monat mittwochs um 13.00 s.t. statt.In zusätzlichen „REBIRTH-Special Lectures“ im Rahmen des Kolloquiums stellen eingeladene auswärtige Referenten ihre Forschungsaktivitäten vor. Das Kolloquium dient als Diskussionsforum von REBIRTH und soll nicht nur die Initiierung externer Kooperationen sondern vor allem die interne (und interdisziplinäre) Zusammenarbeit fördern. Neben externen Referenten stellen deshalb sowohl REBIRTH-Mitglieder als auch Wissenschaftler verwandter Forschungsbereiche aktuelle Daten und Projekte vor. 22.01.2024 REBIRTH Special Lecture (um 12:30 Uhr im Hörsaal Q) ‘The future is here! The next generation of AAV vector as a foundation of cell and gene therapeutics of the future’ Prof. Leszek Lisowski, Translational Vectorology Research Unit, Children’s Medical Research Institute, Faculty of Medicine and Health, The University of Sydney, Westmead, Australia 18.12.2023 REBIRTH Special lecture (5 pm s.t., online Vortrag) ‘Modelling environmentally triggered cell perturbations and their effect on respiratory health with lung organoids’ Dr. Carola Voss, Helmholtz Center Munich 13.12.2023 REBIRTH Kolloquium (1 pm s.t., online Vortrag) ‘RNA-based therapeutic strategies for liver injuries’ Prof. Dr. Amar Deep Sharma, Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology 05.12.2023 REBIRTH Special Lecture (um 16:15 Uhr im Hörsaal O) ‘The multidirectionality of life’ Dr. Miguel A. Esteban, BGI-Research, Hangzhou / Shenzhen 22.11.2023 REBIRTH Kolloquium (1 pm s.t., online Vortrag) ‘Capillary endothelial cells as master regulators of cardiac fibrosis and regeneration’ Prof. Dr. Jörg Heineke, Department of Cardiovascular Physiology, Medical Faculty Mannheim, University of Heidelberg 11.10.2023 REBIRTH Kolloquium (1 pm s.t., online Vortrag) ´When lung regeneration fails - lessons learned from lung fibrosis’ Dr. Jonas Christian Schupp, Clinic of Pneumology and Infectiology, MHH ´Genetic skewing of macrophage function to enhance the therapeutic properties’ Schifaa Abdin (Group of Prof. Dr. Nico Lachmann), Department of Applied Stem Cell and Translational Macrophage Research, MHH 13.09.2023 REBIRTH Kolloquium (1 pm s.t., online Vortrag) ´Precision phenotyping the kidney´ Prof. Dr. Kai Schmidt-Ott, Director of Clinic for Kidney and Hypertension Diseases, MHH ´Relevance of cardiovascular risk factors for novel therapeutic approaches´ Prof. Dr. Rabea Hinkel, German Primate Centre, Leibniz Institute for Primate Research, Department of Laboratory Animal Science 10.05.2023 REBIRTH Kolloquium (1 pm s.t., online Vortrag) ‘Bioinstructive materials to study hematopoietic stem cell niches in health and disease’ Prof. Dr. Cornelia Lee-Thedieck, Executive Director of Institute of Cell Biology and Biophysics at Leibniz University Hannover ‘mRNA and CRISPR for tissue repair in liver diseases’ Prof. Dr. Michael Ott, Department of Gastroenterology, Hepatology and Endocrinology, MHH 19.04.2023 REBIRTH Kolloquium (1 pm s.t., online Vortrag) ‘Aberrant epithelial repair processes in idiopathic pulmonary fibrosis’ Prof. Dr. Antje Prasse, Department of Pneumology, MHH Fraunhofer Institute for Toxicology and Experimental Medicine (ITEM) 22.02.2023 REBIRTH Kolloquium (1 pm s.t., online Vortrag) ‘Genetic engineering of organs to support graft survival after transplantation’ Prof. Dr. Constanca Figueiredo, Institute of Transfusion Medicine and Transplant Engineering, MHH ‘Of drugs and tools - novel concepts for pharmaceutical research ‘ Prof. Dr. Oliver Plettenburg, Medicinal Chemistry at Leibniz University Hannover (and Institute for Medicinal Chemistry, Helmholtz Munich) 18.05.2022 REBIRTH Kolloquium (1 pm s.t., online Vortrag) ‘Role of c-myc in chronic liver diseases’ Prof. Dr. Arndt Vogel, Department of Gastroenterology, Hepatology & Endocrinology, MHH 16.03.2022 REBIRTH Kolloquium (1 pm s.t., online Vortrag) PD Dr. Christina Brandenberger, Institute of Functional and Applied Anatomy, MHH: ‘Epithelial injury and regeneration in senescence and pulmonary aging’ 16.02.2022 REBIRTH Kolloquium (1 pm s.t., online Vortrag) PD Dr. Claudia Neunaber, Unfallchirurgie, MHH: ‘Osteochondral allograft transplantation of the knee’ 19.01.2022 REBIRTH Kolloquium (1 pm s.t., online Vortrag) Prof. Dr. Renata Stripecke, Klinik für Hämatologie, Hämostase, Onkologie und Stammzelltransplantation, MHH: ‘Rebirth of translational immune oncology for leukemias and lymphomas: from the cell engineering, disease models and GMP towards the patients’ 15.12.2021 REBIRTH Kolloquium (1 pm s.t., online und im Hörsaal l R (I6-H0-4050) Prof. Dr. Andrea Hoffmann, Orthopaedic Clinic, MHH: ‘Innovative biomaterials and the future of mesenchymal ʽstemʼ cells’ Prof. Dr. Günter Höglinger Department of Neurology, MHH: ‘Regeneration in Neurodegenerative Diseases - What is Possible?’ 17.11.2021 REBIRTH Kolloquium (1 pm s.t., online und im Hörsaal l R (I6-H0-4050) Dr. Sarah Strauß, Department of Plastic, Aesthetic, Hand and Reconstructive Surgery, MHH: ‘Preliminary Application of Spider Silk in Rats Spinal Cord’ Dr. Ruth Olmer, LEBAO, MHH: ‘iPS derived respiratory and vascular cell types – towards treatment of lung diseases’ 13.10.2021 REBIRTH Kolloquium (1 pm s.t., online und im Hörsaal S (I6-H0-6040) Anna Rafiei Hashtchin, PhD, Institut für Experimentelle Hämatologie, MHH: ‘Moving iPSC-derived macrophages towards clinical applications’ Allan Ertmann Karlsen, Vizepräsident der Zelltherapieforschung, Novo Nordisk: ‘Novo Nordisk’s ambitions in the field of Cell Therapy’ 29.09.2021 - REBIRTH Kolloquium (1 pm s.t., online und im Hörsaal H) PD Dr. Mark Ph. Kühnel, Institut für Pathologie, Laborleiter der Arbeitsgruppe Lungenforschung, Deutsches Zentrum für Lungenforschung (DZL), MHH: ‘COVID-19 – Regenerative Angiogenesis in Lungs and Hearts’ Prof. Dr. Armin Braun, Division Director Preclinical Pharmacology and Toxicology, Fraunhofer ITEM: ‘Drug repurposing as a novel approach in drug development using the example of inhalative therapy against Covid-19’ 14.07.2021 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Prof Dr. Claudia Grothe, Institut für Neuroanatomie und Zellbiologie, MHH: ‘Establishment and validation of an alpha-synuclein parkinson disease rat model – possible protective and replacing therapeutic approaches’ Prof. Dr. Thomas Moritz,Institut für Experimentelle Hämatologie, MHH: ‘Generation of enhanced macrophages for regenerative therapies and beyond’ 02.06.2021 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Dr. Andres Hilfiker, LEBAO, MHH: ‘Decellularized heart valve protheses - from the allogeneic to the xenogeneic graft’ James Thackeray, Ph.D., Klinik für Nuklearmedizin, MHH: ‘Imaging Molecular Markers of Cardiac Injury, Repair and Regeneration’ 05.05.2021 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Dr. Christian Bär, Institut für Molekulare und Translationale Therapiestrategien (IMTTS), MHH: ‘Telomerase as therapeutic target in cardiovascular disease’ Prof. David Zebrowski, Ph.D., Chinese University of Hong Kong, Faculty of Medicine, Department of Medicine & Therapeutics, the Centre for Cardiovascular Genomics and Medicine, and the Hong Kong Hub of Paediatric Excellence (HK HOPE): ‘Cardiomyocyte terminal differentiation, de-differentiation, and the centrosome’ 21.04.2021 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Prof. Dr. Ina Gruh, LEBAO, MHH: ‘Stem cell-derived cardiac cells and tissues for therapy and disease modeling’ Prof. Dr. Alexander Heisterkamp,Institut für Quantenoptik, LUH: ‘Biophotonics - Application of light in cells and tissues’ 10.03.2021 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Prof. Dr. Axel Schambach, Institut für Experimentelle Hämatologie, MHH: ‘From stem cell-based modeling to novel therapeutic strategies’ Dr. Robert Zweigerd, LEBAO, MHH: ‘Making and Maintaining Cardiac Progenitors from human Pluripotent Stem Cells’ 17.02.2021 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Prof. Dr. Hermann Haller, Klinik für Nieren- und Hochdruckerkrankungen, MHH: ‘Regeneration and Aging - Mount Desert Biological Laboratory’ Prof. Dr. Falk Büttner, Institut für Klinische Biochemie, MHH: ‘Identification and validation of a novel glycan cell surface marker for human pluripotent stem cells’ 20.01.2021 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Prof. Dr. Doris Steinemann, Institut für Humangenetik, MHH: 'Repetitive sequences in human genomes and their contribution to disease development' Prof. Dr. Hildegard Büning, Institut für Experimentelle Hämatologie, MHH: 'Tailoring Adeno-Associated Virus (AAV) Vectors for Gene Therapy' Wissenschaftlicher Nachmittag Der wiss. Nachmittag der HTTG-Chirurgie findet alle 2 Monate, mittwochs um 17 c.t., in der Regel im Hörsaal N der MHH, statt. Ziel der Veranstaltung ist die verbesserte Kommunikation zwischen Klinik und Forschung. Zum Teil berichten Mitarbeiter der HTTG-Chirurgie oder des LEBAOs, zum Teil auch Mitglieder der klinischen Forschergruppe „Lungentransplantation“ oder auswärtige Gäste von ihren Untersuchungen und Forschungsergebnissen. Meist spricht ein Referent zu einem klinischen Thema, ein zweiter Referent berichtet von Projekten aus der Forschung. Aufgrund der SARS-CoV-2 Pandemie pausiert der wissenschaftliche Nachmittag derzeit. Frühere Veranstaltungen REBIRTH Kolloquium 2002-2020 2020: 09.12.2020 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Prof. Dr. Dagmar Wirth, Helmholtz Zentrum für Infektionsforschung, Braunschweig: 'Synthetic biology inspired strategies against viral infections' Prof. Dr. Michael Ott, Department of Gastroenterology, Hepatology and Endocrinology, MHH: 'Therapeutic Research in Hepatology' 25.11.2020 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Prof. Dr. Heiner Niemann, Hannover Medical School / TwinCore: 'Recent progress in porcine-to-human xenotransplantation' Prof. Dr. Andreas Kirschning, Institute of Organic Chemistry, Leibniz University Hannover: 'New molecular architectures based on SPIONs and maytansin: YELLOW SUBMARINES for selective drug targeting and release' 28.10.2020 - REBIRTH Kolloquium (1 pm s.t., online Vorträge) Prof. Dr. Constanca Figueiredo, Institut für Transfusionsmedizin, MHH: 'In vitro generation of HLA-silenced Megakaryocytes and Platelets' Univ.-Prof. Dr. med. Kai C. Wollert, Molekulare und Translationale Kardiologie, MHH: 'Myeloid-derived growth factor (MYDGF): pathobiology and therapeutic potential' 23.09.2020 REBIRTH colloquium (1 pm c.t., Hörsaal R, I6-H0-4050) Prof. Dr. Oliver Plettenburg, Direktor des Instituts für Medizinalchemie, Helmholtz Zentrum München: 'Drug Discovery in Academia – Challenges and Opportunities' Prof. Dr. med. Frank Bengel, Direktor der Klinik für Nuklearmedizin, MHH: 'Image-guided cardiac repair' 08.07.2020 REBIRTH colloquium (1 pm c.t., Hörsaal R, I6-H0-4050) Prof. Dr. Dr. med. Thomas Thum, Institut für Molekulare und Translationale Therapiestrategien, MHH: 'Noncoding RNA therapeutics on their way to clinical reality' PD Dr. Amar Deep Sharma, Klinik für Gastroenterologie, Hepatologie und Endokrinologie, MHH: 'Regenerative medicine for the dysfunctional liver' 26.02.2020 - REBIRTH colloquium (5 pm c.t., Lecture Hall H) Priv.-Doz. Dr. Nico Lachmann, Institute for Experimental Hematology, MHH: 'The plasticity of macrophages: from basic biology to cellular therapies' 2019: 30.01.2019 Special lecture (5 pm c.t., Lecture Hall G) Prof. Dr. Cornelia Lee-Thedieck, Leibniz University Hannover, Institute of Cell Biology and Biophysics, Hannover 'Towards an artificial stem cell niche: biomaterials for directing hematopoietic stem cell behavior' 2018: 28.11.2018 - REBIRTH colloquium (5 pm c.t., Lecture Hall G) Prof. Dr. med. Uwe Tegtbur, Institut für Sportmedizin, Medizinische Hochschule Hannover: Rebirth active studies –results and perspectives for children right up to higher age 12.09.2018 - REBIRTH colloquium (5 pm c.t., Lecture Hall G) Prof. Dr. Gudrun Göhring, Cellular and Molecular Pathology, Hannover Medical School: 'Genetic instability of hematological neoplasia- interaction of diagnostics and research' Prof. Dr. Ursula Rinas, Technical Chemistry, Leibniz University of Hannover: 'Sick microorganisms: autophagy in protein producing yeast'. 16.05.2018 - REBIRTH colloquium (5 pm c.t., Lecture Hall N) Dr. Amar Deep Sharma, PhD, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School: ‘Regenerative Medicine for the Dysfunctional Liver‘ Dr. rer. nat. Stefan Kalies, Institute for Quantum Optics,Leibniz University Hannover: ‘Identifying regeneration mechanisms via imaging and cell manipulation using ultrashort laser pulses‘. 17.01.2018 - REBIRTH colloquium (5 pm c.t., Lecture Hall M) Prof. Dr. Christian Mühlfeld, Institute of Functional and Applied Anatomy, Hannover Medical School: 'Quantification and 3D reconstruction of the pulmonary vasculature – Potential for pathogenetic and developmental research' Prof. Dr. Evgeni Ponimaskin, Cellular Neurophysiology, Hannover Medical School: 'Quantitative molecular microscopy to study the multifaceted role of serotonergic system'. 2017: 29.11.2017 - Special Lecture (15:00 pm) Prof. Dr. Emrah Düzel, DZNE. 08.11.2017 - REBIRTH colloquium (5 pm c.t., Lecture Hall G) Prof. Dr. Theresia Kraft, Institute for Molecular- and Cellphysiology, Hannover Medical School: 'Cardiac disease models: from human stem-cell derived cardiomyocytes to transgenic pigs' Prof. Dr. Falk F. R. Büttner, Institute for Clinical Biochemistry, Hannover Medical School: 'Glycoanalytics in stem cell research: 'Towards understanding the unprecedented richness of the cellular glycome'. 23.10.2017 - Special Lecture (17:00 pm c.t.,TWINCORE, Zentrum für Experimentelle und Klinische Infektionsforschung GmbH Raum Nr. 0020, Gebäude M04 Feodor-Lynen-Str. 7 30625 Hannover) Noriyuki Kasahara, MD PhD, Professor, Departments of Cell Biology and Pathology, University of Miami: Rebirth of 'Immuno/Gene Therapy for Cancer: Preclinical Development and Clinical Translation'. Host: Prof. Dr. Hildegard Büning, +49 (0) 511 532 5106, Prof. Dr. Renata Stripecke, +49 (0) 511 532 6999 06.09.2017 - REBIRTH colloquium (5 pm c.t., Lecture Hall G) Prof. Dr. Jörg Heineke, Experimental Cardiology,Hannover Medical School: 'Treating heart failure through regulation of secreted long non-coding RNAs?' PD Dr. Ina Gruh, Leibniz Research Labs for Biotechnology and Artificial Organs (LEBAO), Hannover Medical School: 'Bioartificial cardiac tissue for transplantation and disease modelling'. 03.07.2017 - Special Lecture (16:00 pm c.t.,Lecture Hall M) Prof. Jacinta Bustamante MD, PhD, Laboratory of Human Genetics of Infectious Diseases, INSERM, Paris; Center for the Study of Primary Immunodeficiencies, Necker Hospital for Sick Children, Paris; Howard Hughes Medical Institute, New York, USA: '“Genetic dissection of atypical mycobacterial infectious diseases in human”'. Host: PD Dr. Nico Lachmann, Tel. 5266 15.05.2017 - Special Lecture (15:00 pm c.t., Building M20, S0, Seminar room 2520, Lower Saxony Centre for Biomedical Engineering, Implant Research and Development (NIFE), Stadtfelddamm 34, 30625 Hannover) Assoc. Prof. Dr. Elias Anastassopoulos, Department of Agricultural Technologists, TEI of Thessaly, Larissa, Greece: 'Freezing in Nature. What can we learn for cryopreservation purposes?'. Contact: Dr. Oleksandr Gryshkov / AG Glasmacher Tel.: 0511 / 762-3827 (IMP) / 532-1342 (NIFE) 10.05.2017 - REBIRTH colloquium (5 pm c.t., Lecture Hall Q) Prof. Dr. Anette Melk, Interdisciplinary Experimental Transplant Medicine, Hannover Medical School: 'Senescence and endothelial dysfunction' Prof. Dr. Dagmar Wirth, RG MSYS - Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research: 'Functionalization of cells by rewiring endogenous regulatory circuits with synthetic expression modules'. 08.05.2017 - Special Lecture (13:30 pm c.t., Building M20, S0, Seminar room 2520, Lower Saxony Centre for Biomedical Engineering, Implant Research and Development (NIFE), Stadtfelddamm 34, 30625 Hannover) Prof. Dr. Gennadiy Zhegunov, Department of Biochemistry, Kharkov State Zooveterinary Academy, Ukraine: 'A novel approach in complex treatment of babesiosis in dogs with application of cryopreserved red blood cells'. Contact: Dr. Oleksandr Gryshkov / AG Glasmacher Tel.: 0511 / 762-3822 (IMP) / 532-1342 (NIFE) 19.04.2017 - Special Lecture (5 pm c.t., Lecture Hall G) Dr. Luca Biasco, Gene Therapy Program, Dana-Farber/Boston Children’s Cancer and Blood Disorders Center: 'Clonal Tracking of Human Hematopoiesis Through Integration Sites Analysis'. Host: Prof. Axel Schambach, Tel.: 5170 08.03.2017 - REBIRTH colloquium (5 pm c.t., Lecture Hall E) Prof. Dr. Thomas Moritz, Institute of Experimental Hematology, Hannover Medical School: 'Pulmonary Macrophage Transplantation - Pulmonary Alveolar Proteinosis and beyond' Prof. Dr. Andreas Kispert, Institute of Molecular Biology, Hannover Medical School: 'Integration of signaling activities by Tbx2 in lung development and disease'. 21.02.2017 - Special Lecture (5 pm s.t., Lecture Hall G) Ph.D. Dr. Hab. Ebba Brakenhielm, Inserm U1096, Institute for Research and Innovation in Biomedicine, Normandy University & University of Rouen, France: 'Cardiac lymphangiogenesis – a new target for prevention of heart failure?' Host: Prof. Dr. Denise Hilfiker-Kleiner, 2531 Prof. Dr. Axel Haverich, 6581. 20.02.2017 - Special Lecture (5 pm c.t., Lecture Hall M) Prof. Dr. rer. nat. Hans-Joachim Knölker, Department Chemie, Technische Universität Dresden: 'Efficient Synthetic Routes to Biologically Active Carbazole Alkaloids'. Contact: Prof. Dr. Rita Gerardy-Schahn Tel. 0511 / 532-9802 18.01.2017 - REBIRTH colloquium (5 pm c.t., Lecture Hall ZIMt K4) Prof. Dr. Renata Stripecke, Department of Hematology, Hemostasis, Oncology and Stem Cell Transplantation,Hannover Medical School: 'Immune therapy with engineered DCs and T cells for accelerated immune regeneration after stem cell transplantation‘ and PD Dr. Nico Lachmann, Institute of Experimental Hematology, Hannover Medical School: ‘Brave new world: Hematopoiesis from the bioreactor to regenerate pulmonary immunity.‘ 2016: 09.11.2016 - REBIRTH colloquium ( 5 pm c.t., Lecture Hall N ) Prof. Dr. rer. nat. Armin Braun, Division Director, Fraunhofer Institute for Toxicology and Experimental Medicine: ‘Bringing Innovative therapies into the clinic considering a highly regulated environment‘. Univ.-Prof. Dr. med. Daniel Sedding, Department of Cardiology and Angiology, Hannover Medical School: ‘Mechanismen des vaskulären Remodelings‘. 21.09.2016 - REBIRTH colloquium ( 5 pm c.t., Lecture Hall Q ) Prof. Dr. Boris Chichkov, Laser Zentrum Hannover e.V., Leibniz University of Hannover: '3D laser printing of scaffolds, nanoparticles, and living cells' Dr. Andres Hilfiker, Leibniz Research Labs for Biotechnology and Artificial Organs (LEBAO), Dept. of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School: Myocardial Tissue Engineering. 10.08.2016, Special Lecture (Lecture Hall H, 17 s.t.) Prof. Jonathan Kimmelman, Associate Professor, Biomedical Ethics Unit, McGill University, Chair of the ISSCR ethics committee: ‘The ISSCR Guidelines for Stem Cell Research and Clinical Translation: Presentation and Discussion of its Relevance and Applicability in Germany’. 23.06.2016, Special Lecture (6 pm, Seminar room, HBZ) Prof. Dr. Fang Yang, State Key Laboratory of Bioelectronics, Jiangsu Key Laboratory for Biomaterials and Devices, School of Biological Science and Medical Engineering, Southeast University, Nanjing, China: ‘Ultrasound assisted magnetic microbubble delivery system for multimodal theranostics’. 17.06.2016, Special Lecture (Lecture Hall G, 15 s.t.) Professor David Williams, MD, Chief, Division of Hematology/Oncology, Boston Children‘s Hospital, Director of Clinical and Translational Research, BCH, Associate Chairman, Dep. of Ped. Oncology, Dana-Farber Cancer Institute: ‘Gene therapy in monogenic diseases, a platform for gene editing in the clinic‘ 11.05.2016 - REBIRTH colloquium ( 5 pm c.t., Lecture Hall M ) PD Dr. med. Serghei Cebotari, Dept. of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School: ‘Clinical implantation of tissue engineered heart valves‘ Prof. Dr. Ir. Wim Wolkers, Institute of Multiphase Processes, Leibniz University of Hannover: ‘Dry preservation of mammalian cells and tissues inspired by lessons from nature’ 28.04.2016, Special lecture (6.00 pm s.t., Lecture Hall H, building I1, MHH) Prof. Dr. Dr. Thomas Thum, Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School: ‘Interdisciplinary challenges of translational medicine and regulatory needs’ Prof. Dr. Dr. h.c. Michael Qante, Department of Philosophy, Westfälische Wilhelms University Münster: ‘Interdisciplinarity and Trans-Disciplinary Deliberation in Research and Higher Education’. 18.03.2016, Special lecture (1 pm c.t., lecture hall H, building I1, MHH) Prof. Dr. Jens Madsen, University of Southampton, UK: ‘The Yin-Yang of Airway Lectins and Bugs: To Bind or not to Bind?’ 23.02.2016, Special Lecture (4 p.m. c.t., HBZ seminar room (I11-S0-6040), MHH) Prof. Yair Reisner, Dep. Immunology, Weizmann Inst. Of Science, Rehovot, Israel ‘Towards lung healing by committed lung progenitors: The lung niche and other analogies to bone marrow transplantation’ 01.02.2016, Special Lecture (Lecture Hall H, 5 p.m. s.t.) Dr. Lars Maegdevessel, MD, PhD, Karolinska Institute Stockholm, Denmark „Non-coding RNAs in vascular disease detection and therapy“ 15.01.2016, Special Lecture (11 am s.t., Lecture room of the Institute for Multiphase Processes, Callinstr. 36, 30167 Hannover) Prof. Dr. Johannes Schenkel, German Cancer Research Center Heidelberg; Cryopreservation W430: ‘Cryopreservation of mutant mice – benefits and challenges’ 13.01.2016 - REBIRTH colloquium (Lecture Hall M, 5.15 pm) Prof. Dr. P. M. Vogt, Dept. Plastic, Hand and Reconstructive Surgery, Hannover Medical School: ‘Regenerative concepts in plastic surgery’ Dr. Gerald Dräger, Institute of Organic Chemistry, Leibniz University of Hannover: ‘From Materials to Surfaces and back again‘. 2015: 16.11.2015, Special Lecture (Lecture Hall H 4.45 pm) Dr. Bernhard Gentner, Translational Stem Cell and Leukemia Research Unit, Department San Raffaele Hospital and Telethon Institute for Gene Therapy (TIGET), Milano, Italy: „Stem Cell Programs in Leukemia and Programming Hematopoietic Stem Cells against Cancer “ 10.11.2015, Special Lecture (Lecture Hall M, 4.15 pm c.t.) Prof. Dr. Frédéric Geissmann, William E. Snee Chair of Immunology, Memorial Sloan Kettering Cancer Center, New York City, USA: „The Layered Macrophage System“ 4.11.2015 (5 pm c.t., Lecture Hall N) Prof. Dr. Dagmar Wirth, Head of the Research Group (MSYS) Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, Braunschweig: ‘Controlled interventions in regulatory networks of cells and mice utilizing synthetic biology strategies’ PD Dr. Constanca Figueiredo, Institute for Transfusion Medicine, Research Group Cellular Therapy, Hannover Medical School, Hannover: ‘Towards the generation of invisible transplants: HLA-universal cells and tissues to prevent rejection after transplantation‘ 22.10.2015, Special Lecture (BMWZ, Seminarraum, EG, Schneiderberg 38, 5 pm s.t.) Dr. Sophia Efstathiou, Norwegian University of Science and Technology: “Explicating Ethics: The Case of Animal Research” 16.10.2015, Special lecture (12 noon s.t., in seminar room of the HBZ, J11, S0, room 6040, MHH) Prof. Katja Schenke-Layland, Head of the Dept. Cell and Tissue Engineering, Fraunhofer Institute for Interfacial Engineering and Biotechnology IGB, Stuttgart: „Impact of biomedical technologies on regenerative medicine“ 28.09.2015, Special lecture (Lecture Hall H, 17:00 st) Prof. Dr. Gianluigi Condorelli, MD, PhD, Director of Cardiovascular Research Area and Head of Lab Humanitas Clinical and Research Center, Milan, Italy: "Epigenetics and myocardial function” 16.9.2015, Special lecture (Lecture Hall H, 1.00 pm s.t.) David Kaplan & Carolyn Yong, FDA - U.S. Dept. of Health and Human Services, Office of Science and Engineering Laboratories & Office of Cellular, Tissue, and Gene Therapies: „Considerations for Tissue Engineered Medical Products (TEMPs): US FDA Regulatory Perspective“ 09.09.2015, (5 pm c.t. in Lecture Hall N, MHH) Prof. Dr. Alexander Heisterkamp, Applied Laser Physics, Institute for Quantum Optics, Gottfried Wilhelm Leibniz University Hannover, Hannover: Part 1: ‘New optical tools for microscopic imaging‘ Prof. Dr. med. Matthias Ochs, Institute for Functional and Applied Anatomy, Hannover Medical School, Hannover: Part 2: ‘Using microscopes to look into the lung’ 08.09.2015, Special Lecture (11 am c.t., Walsroder Hörsaal, Callinstr. 5, 2nd floor) Antonio Villaverde, Chair Professor of Microbiology, Universitat Autònoma de Barcelona: „Quality control in the biofabrication of smart protein materials“ 24.07.2015, Special lecture (9 am s.t., in seminar room of the HBZ, J11, S0, room 6040, MHH) Prof. Hossein Baharvand, Dept. of Stem Cells and Developmental Biology, Director of Royan Institute for Stem Cell Biology and Technology, Tehran, Iran: „A Robust Integrated Platform for Scalable Production of Human Hepatocyte-like Cells and Cardiomyocytes from Pluripotent Stem Cells in Stirred Suspension Bioreactor“ 18.06.2015, Special lecture (5.00 pm ct, Lecture Hall M, building J1, MHH) Prof. Dr. jur. Jens Kersten, Lehrstuhl für Öffentliches Recht und Verwaltungswissenschaften, Juristische Fakultät, Ludwig-Maximilians Universität, München: “Brauchen wir ein Biobank-Gesetz?” 27.05.2015, (4 pm s.t. in Lecture Hall G, MHH) Ph.D. Micha Drukker, Institute for Stem Cell Research, Helmholtz Institute Munich, Munich: ‘Human developmental progenitors, the curious case of trophoblast differentiation’ Dr. rer. nat. Robert Zweigerdt, Leibniz Research Laboratories for Biotechnology and Artificial Organs, Hannover Medical School, Hannover: ‘Progress in mass culture and differentiation of human pluripotent stem cells’ 8.05.2015, Special lecture (2 pm, Lecture room of the Institute for Multiphase Processes, Callinstr. 36, 30167 Hannover (LUH)) Prof. Dr. Gennadiy Zhegunov, Department of Biochemistry, Kharkov State Zooveterinary: “ Physiological, biochemical and applied aspects of hibernation” 11.03.2015, (5 pm s.t. in Lecture Hall N, MHH) Prof. Dr. Dr. med. Thomas Thum, Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School: "Paracrine and translational importance of noncoding RNAs" Prof. Dr. med. Kai Wollert, Molecular and Translational Cardiology, Dept. of Cardiology and Angiology, Hannover Medical School: "Myocardial infarct healing as a therapeutic target" 16.02.2015, Special lecture (11 am, Seminar Room Cellular Chemistry, I03-04-2040, MHH) Dr. Philipp Schmalhorst, Institute of Science and Technology Austria (IST Austria), Klosterneuburg, Austria: “The influence of sialylation on cadherin-mediated cell-cell adhesion” 4.02.2015, Special lecture ( 5 pm c.t., Lecture Hall Q, I06-S0-4100, MHH) Dr. Catherine Merry, Stem Cell Glycobiology, Materials Science, University of Manchester, UK: “Sugar-coated webs to drive stem cell differentiation” 3.02.2015, Special lecture (12.00 am s.t., midday, seminar room I06-01-2013, MHH) Petter S. Woll, PhD, Hematopoietic Stem Cell Laboratory (Jacobsen Lab), Weatherall Institute for Molecular Medicine, University of Oxford, UK “Genetic fate mapping of cancer stem cells in myelodysplastic syndrome patients” 22.01.2015, Special lecture (5 pm s.t., Lecture Hall Q) Prof. Mark von Itzstein FAA FRACI, Director of the Institute for Glycomics, Griffith University, Gold Coast Campus, Queensland, Australia: 'Chemical Glycobiology and Targeting-Disease Processes' 20.01.2015, Special lecture (5 pm s.t., Lecture Hall G) Prof. Joel Clinton Glover, Department of Physiology, Institute of Basic Medical Science, University of Oslo 'Plasticity and functional recovery after traumatic injury in the neonatal spinal cord' 19.1.2015, Special lecture (5 pm s.t., Lecture Hall G, MHH) Gareth J Sullivan, PhD, Department of Physiology, Institute of Basic Medical Science, University of Oslo: “hPSC differentiation to hepatocytes – a farewell to growth factors” 15.01.2015, Special lecture (5 pm s.t., Lecture Hall N, MHH) Prof. Hiroshi Nagashima, PhD, Laboratory of Developmental Engineering, Department of Life Sciences, School of Agriculture, Meiji University, 1-1-1 Higashimita, Tama, Kawasaki 214-8571, Japan 'Challenge to in-vivo organ regeneration using organogenesis-disabled pig as a platform' 14.01.2015 (5 pm c.t., Lecture Hall N, MHH) Dr. Peter Nussbaumer, Managing Director & Head of Medicinal Chemistry, Lead Discovery Center GmbH, Dortmund: ‘Translating academic science into pharmaceutical application’ Dr. Gerald Dräger, Institute of Organic Chemistry, Leibniz University of Hannover: ‘Towards Biocompatible Medical Devices and Artificial Extracellular Matrices’ 2014: 12.11.2014 (5 pm c.t., Lecture Hall N, MHH) Dr. rer. nat. Jens Peter von Kries, Leibniz Research Institute for Molecular Pharmacology (FMP) im Forschungsverbund Berlin e.V., Berlin: "HIGH THROUGHPUT SCREENING FOR IDENTIFICATION OF DRUGS AND FOR GENOME-WIDE RNA INTERFERENCE" Prof. Dr. Salim Seyfried, Max-Delbrück-Center for Molecular Medicine (MDC) / Institute of Molecular Biology, Hannover Medical School: "ZEBRAFISH TROUGH THE LOOKING GLASS: AN IN VIVO GLIMPSE AT CARDIOVASCULAR DEVELOPMENT AND PATHOLOGIES" 4.11.2014, Special lecture (12.00 am c.t., Seminar Room of the Institute of Human Genetics, Theoretische Institute II, Building I6, Level 01, Room 2013, MHH) Jude Fitzgibbon, BA, PhD, Centre for Haemato-Oncology Barts Cancer Institute, Queen Mary University of London John Vane Science Centre, Charterhouse Square, London, UK `Follicular lymphoma, it’s now much more than just the t (14;18)` 13.10.2014, Special lecture (11 am s.t., Lecture Hall M, I01-01-1140, MHH) Hisashi Narimatsu, MD & PhD, Director of the Research Center for Medical Glycoscience National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan: “Development and clinical application of a liver fibrosis marker” 25.09.2014, REBIRTH-Special Lecture (5 pm, seminar room 30, K05-02, MHH) Prof. John W. Elrod, PhD, Temple University School of Medicine, Center for Translational Medicine, Philadelphia, USA: “Synaptolysis – A novel mechanism of programmed necrosis” 17.09.2014 (5 pm c.t., Lecture Hall N) Prof. Dr. Marlies Knipper, Department of Otolaryngology, Head and Neck Surgery, Hearing Research Centre Tuebingen, Molecular Physiology of Hearing, University of Tuebingen: ‘FUTURE OF BIOMEDICAL RESEARCH IN INNER EAR BIOLOGY’ PD Dr. med. Athanasia Warnecke, Department of Otorhinolaryngology, Head and Neck Surgery, Hannover Medical School: ‘BIOHYBRID ELECTRODES FOR REGENERATION OF THE INNER EAR’ 10.07.2014, REBIRTH-Special Lecture (5 pm, seminar room cellular chemistry I 03-04-2040) Prof. Dr. Sabine Strahl, University of Heidelberg, Centre for Organismal Sudies (COS) – Cell Chemistry “Protein O-Mannosylation: News and Views” 03.07.2014, Special Lecture (5.00 pm, Lecture Hall G (I 1), MHH) Dr. Jeroen Krijgsveld, European Molecular Biology Laboratory (EMBL), Heidelberg, Germany: "Novel approaches in chromatin-centered proteomics to investigate pluripotency and development" 07.05.2014 (5 pm c.t., Lecture Hall N, MHH) Prof. Dr. med. N.P. Malek, Medical Director, Department of Internal Medicine 1, (Hepatology, Gastroenterology, Infectious Diseases), University Hospital Tübingen: ‘Differentiation and transformation of hepatic stem cells’ Dr. Amar Deep Sharma, PhD, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School: ‘Harnessing the potential of microRNAs to boost liver regeneration’ 05.05.2014, Special lecture (5.00 pm, Lecture room of the Institute of Multiphase Processes, Callinstr. 36, 30167 Hannover) Prof. Dr. Gennadiy Zhegunov, Department of Biochemistry, Kharkov State Zooveterinary Academy: “New cryotechnologies with HES for long term storage of cat and cannie red blood cells for transfusion” 25.04.2014, Special lecture (2.30 pm, Lecture Hall N, MHH) Prof. Dr. Michael S.D. Kormann: Universitätsklinik für Kinder- und Jugendmedizin, Tübingen, AG Translationale Genomik und Gentherapie: “In vivo genome manipulation using nuclease encoded chemically modified mRNA” 14.04.2014, Special lecture (5.00 pm, Seminar Room 30, Bldg. K05, Level 02, 2370, MHH) Dr. Kevin Croce, Brigham and Women’s Hospital, Harvard Medical School, Boston, USA: “Platelet Profiling Identifies MRP-14 as a Novel Regulator of Vascular Inflammation” 14.03.2014, Special lecture (2.00 p.m. in the HBZ seminar room, MHH, building I11, Level S0) Dr. Mervin Yoder, MD, Director of Herman B Wells Center of Pediatric Research, Indianapolis, USA: “Generation of human endothelial colony cells with vascular reparative properties from human induced pluripotent stem cells” 04.03.2014, Special lecture (1.00 p.m. c.t., Seminar Room of the Institute of Cell and Molecular Pathology, Theoretische Institut II (Bldg. I6) Level 01, Room 2013) Alejandro Vaquero García, BSc, PhD, Group Leader Chromatin Biology Lab,Cancer and Epigenetics Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Spain: “The role of sirtuins in genome stability” 03.02.2014, Special lecture (5 pm, Lecture Hall G) Prof. David Newby, BHF Centre for Cardiovascular Science University of Edinburgh “Imaging the Vulnerable Coronary Plaque with Antimatter: Chalk and Cheese” 15.01.2014 (5 pm c.t., Lecture Hall M) Prof. Evžen Amler, PhD, Institute of Experimental Medicine, Prag, Czech Republik: ‘Functionalized nanofibers for tissue engineering and drug delivery systems’ 13.01.2014, Special lecture (2.00 pm, Lecture Hall H, MHH) Prof. Dr. Hans J. Wester, Technische Universität München, Chair of Pharmaceutical Radiochemistry: “Molekulare Bildgebung von Chemokin-Rezeptoren” 18.11.2013, Special lecture (3 pm. s.t., in HBZ Seminar room (J11), MHH) Julia Jung, Working Group Robert David, Reference and Translation Center for Cardiac Stem Cell Therapy (RTC), University of Rostock: ‚Cardiac Pacemaker Cells from ES Cells‘ 06.11.2013 (5 pm c.t., in Lecture Hall M) Prof. Dr. Jerzy Adamski, Genome Analysis Center, Institute of Experimental Genetics, Helmholtz Zentrum München, Neuherberg: ‘Analysis of cell differentiation by metabolomics’ Ass. Prof. Dr. Falk Büttner, Department of Cellular Chemistry, Hannover Medical School: ‘Cleavage of E-cadherin and b-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells‘ 25.10.2013, Special lecture (10 a.m. s.t., in HBZ Seminar room, MHH) Ass. Prof. Bob Scholte, PhD, Cell Biology Department, Erasmus MC University, Netherland: ‚Present and future models of chronic lung disease, towards cellular therapy of cystic fibrosis‘ 04.09.2013 (Lecture Hall O, K20, S0, 2030) Prof. Sonja Schrepfer, Transplant and Stem Cell Immunobiology Lab (TSI), University Heart Center Hamburg ‘Immunological challenge of pluripotent stem cells in myocardial regeneration’ Prof. Andreas Kirschning, Institute of Organic Chemistry, Leibniz University of Hannover ‘The Center of Biomolecular Research (BMWZ) at the Leibniz University in Hannover – a partner for REBIRTH and NIFE‘ 03.09.2013, Special Lecture (6.00 pm, HBZ Seminar Room, I11-S0-6040) Professor Dr. med. Michael Schmitt, MBHA, Siebeneicher Endowment Professor of Cellular Immunotherapy, Medizinische Klinik V, University of Heidelberg “Lost in Translation? Risks and Opportunities in Translational Immunology” 23.08.2013 Special Lecture (12.00 noon s.t., Seminar Room 3242, K11-S0-3242) Professor Christina Bonorino, PhD, Laboratory of Cellular and Molecular Immunology, Biomedical Research Institute, Pontifical Catholic University of Rio Grande do Sul (PUCRS), Porto Alegre, Brazil “Role of a neuropeptide in neutrophil migration and tumor growth” 02.08.2013, Special lecture (12.00 Uhr s.t., Seminarraum 226, Institute for Multiphase Processes, Callinstr. 36, 30167 Hannover) John C. Bischof University of Minnesota Department of Mechanical Engineering "Nanoparticle Heating for Biomedical Applications" 26.07.2013 Special Lecture (5.30 p.m., Institute of Farm Animal Genetics, Friedrich-Loeffler-Institute, Mariensee, Höltystraße 10, 31535 Neustadt) Professor Dr. rer. nat. Boris Fehse, Clinic for Stem Cell Transplantation, University Clinic Hamburg-Eppendorf “Translational Research in Cell and Gene-Therapy, A Scientists Perspective” 19.06.2013 (5 p.m. c.t. Lecture Hall E) Prof. Felix Engel, PhD, Experimental Renal and Cardiovascular Research, Department of Nephropathology, Institute of Pathology, University of Erlangen: ‘Cardiac regeneration: from cardiomyocyte proliferation to tissue engineering’ Prof. Michael Ott, MD, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School: ‘Cell and gene therapeutic approaches for liver diseases!’ 30.04.2013, Special lecture (4 p.m. s.t., lecture Hall H (I01-H0-1110) Zolt Arany MD PhD, Cardiovascular Institute, Beth Israel Deaconess Medical Center and Harvard Medical School: “Role of PGC-1s in skeletal muscle metabolism” 25.04.2013, Special lecture (6 pm s.t., Lecture Room of the Institute for Multiphase Processes, Callinstr. 36, 30167 Hannover) Prof. Dr. Gennadiy ZhegunovDepartment of Biochemistry, Kharkov State Zooveterinary Academy: „Cryopreservation of erythrocytes of some domestic animals" 28.03.2013, Special lecture (4.00 p.m. s.t., seminar room Institute of Multiphase Processes (2nd floor), Callinstrasse 36, Hannover) Prof. Dr. John H. Crowe, Department of Molecular and Cellular Biology, University of California Davis, CA, USA Preservation of Living Cells in the Dry State: Lessons from Nature 27.03.2013 (5 p.m. c.t. , Lecture Hall H) Prof. Philipp Sasse, MD, Institute of Physiology I, University of Bonn, Life & Brain Center: “New experimental approaches for the diagnosis and therapy of cardiac arrhythmias” 18.03.2013, Special lecture (5 p.m. c.t., lecture Hall M) Prof. Dr. Miguel A. Esteban, MD PhD, South China Institute of Stem Cell & Regenerative Medicine Guangzhou Institutes for Biomedicine and Health (GIBH) Chinese Academy of Sciences (CAS): “Role of histone deacetylases in somatic cell reprogramming” 13.03.2013, 5 pm (c.t.), Lecture Hall B Tomas Huser, PhD, Biomolecular Photonics, Department of Physics, University of Bielefeld: ‘Characterization of embryonic stem cells and their derivatives by label-free spectroscopy and microscopy’ Dr.-Ing. Heiko Meyer, Biomedical Optics Department, Biophotonic Imaging and Manipulation, Laser Center Hannover: ‘Large Scale Volumetric Microscopy’ 04.03.2013, Special lecture (1 pm s.t., seminar room in building I03, floor 04, room 2040) Prof. Dr. Lars Nitschke, University of Erlangen – Biologikum – Division of Genetics CD22 and Siglec-G:Inhibitory receptors on B lymphocytes 16.01.2013 (5 pm c.t. Lecture Hall M) Prof. Dimosthenis Mavrilas, PhD, Laboratory of Biomechanics & Biomedical Engineering, Department of Mechanical Engineering & Aeronautics, University of Patras, Greece: ‘Decellularised Natural Collagenous Biomaterials for Cardiovascular Tissue Engineering: Biomechanical, Biochemical and Biological characteristics’ Dr. Sotiris Korossis, PhD, Director of Biomedical Engineering, Lower Saxony Centre for Biomedical Engineering, Implant Research and Development, Hannover Medical School, Hannover: ‘Investigation of the Suitability of Decellularised Porcine Pericardium in Mitral Valve Reconstruction’ 13.11.2012, Special lecture (2.00 p.m., s.t. , Lecture Hall M, I01-02-1140) Prof. Dr. Markus Löffler, Institut für Medizinische Informatik, Statistik und Epidemiologie, Universität Leipzig: Systems biology of stem cell and tissue organization in regenerating tissues–A model perspective 06.11.2012 (6 pm c.t., Lecture Hall N) Prof. Eva Mischak-Weissinger, PhD, Clinic for Haematology, Haemostaseology and Oncology, Hannover Medical School, Hannover: Urinary and Plasma Biomarkers for Acute Graft-Versus-Host Disease Prof. Dr. Thomas Moritz, REBIRTH Cluster-of Excellence, Hannover Medical School, Hannover: Targets – Which Cells to Transduce in Gene Therapy Approaches for Haematologic Diseases 17.09.2012, Special lecture (3.15 p.m. , Seminar room Zelluläre Chemie, I03-04-22) Dr. Stefanie Barbirz, AG Physikalische Biochemie, Universität Potsdam – Campus Golm: Pathogen invasion by bacteriophages: Carbohydrate recognition and impacts for therapeutic applications 24.08.2012, Special lecture (4.00 p.m., s.t., Lecture Hall H) PD Dr. Salim Seyfried, Max-Delbrück-Centrum für Molekulare Medizin (MDC) Berlin-Buch, Robert-Rössle-Straße 10, 13125 Berlin: Molecular control of cardiac morphogenesis in zebrafish 29.06.2012, Special lecture (11.00 a.m., s.t., HBZ seminar room, building I11) Dr. Thorsten M. Schlaeger, PhD, Head, Human Embryonic Stem Cell CoreInstructor, Harvard Medical School (Boston): Shedding light on reprogramming 28.06.2012, Special lecture (5.00 p.m.,c.t., Lecture Hall N) Professor Ferdinand LeNoble, Max Delbrueck Center for Molecular Medicine, AG Angiogenesis and Cardiovascular Pathology, Berlin, Germany: Guidance cues in organ development. Zebrafish as a tool to study development of blood vessels, liver and nerves 26.06.2012, Special lecture (5.15 p.m., s.t., Institute of Farm Animal Genetics (ING), conference room „Pferdestall“ in Mariensee) Dr. Michael Milsom, Hi-Stem Institut für Stammzellforschung, Heidelberg: Getting blood out of an EB: the challenges of hematopoietic specification from pluripotent cell lines. 06.06.2012, Special lecture (3.00 p.m., s.t., HBZ seminar room) Otavio Cabral Marques, MSc, PhD candidate, University of São Paulo (USP), Brazil: X-linked hyper-IgM patients present impaired responses to Candida albicansand Paracoccidioides brasiliensis: Immunopathological mechanisms in CD40 ligand deficiency 04.06.2012, Special lecture (5.00 p.m., s.t., Lecture Hall N) Professor Dr. phil. Ioannis Missirlis, Department of Mechanical Engineering & AeronauticsLaboratory of Biomechanics & Biomedical Engineering, University of Patras: A Multiple Stimuli Approach for the Engineering of Functional Tissues 31.05.2012, Special lecture (6.00 p.m., c.t., Lecture Hall H) Prof. Dr. med. Dr. phil. Thomas Heinemann, Lehrstuhl für Ethik, Theorie und Geschichte der Medizin, Philosophisch-Theologische Hochschule Vallendar: Prognosis-relevant incidental findings in iPS cells derived from own or non-anonymized tissue samples: ethical considerations and possible solutions 30.05.2012, Special lecture (6.00 p.m., c.t., Lecture Hall B) Jeroen Bakkers, PhD, Hubrecht Institute Uppsalalaan8, 3584 CT Utrecht, The Netherlands: Zebrafish as a tool to study myocardial differentationand regeneration 20.05.2012, Special lecture (5 p.m., s.t., HBZ Seminar room) José Alexandre M. Barbuto, Dept. of Immunology, Institute of Biomedical Sciences, USP, São Paulo, SP, Brazil: Monocyte-derived dendritic cells in human cancer: their status in patients and possible therapeutic applications 15.05.2012, Special lecture (5 p.m., s.t., lecture hall G) Prof. Zoltan Arany, MD, PhD, Cardiovascular Institute Beth Israel Deaconess Medical Center Harvard Medical School CLS 906 3 Blackfan Circle Boston MA 02115: Broken Hearts: PGC-1alpha, Cardiac Angiogenic Imbalances, and Peripartum Cardiomyopathy 25.04.2012, Special lecture (3.00 p.m. (s.t.), HBZ Seminar room, MHH) PD Dr. Harald Schulze, Institute of Transfusion Medicine, Charité, Berlin: Thrombocytopenia with absent radii (TAR) is caused by RBM8A deficiency, a gene encoding one of the four exon-junction complex subunits Y14 13.04.2012, Special lecture (lecture hall N, 2 pm, c.t.) Nicole Dubois, Ph.D., McEwen Centre for Regenerative Medicine, Toronto, Canada: Generation and characterization of cardiomyocytes derived from human pluripotent stem cells 10.04.2012, Special lecture (6 p.m., s.t., lecture hall N) Dr. Ido Braslavsky, Department of Physics and Astronomy, Ohio University, Athens, Ohio & Faculty of Agriculture, Food, and Environment at the Hebrew University of Jerusalem, Rehovot, Israel: Freeze control by ice binding proteins 21.03.2012 Special lecture (1.00 p.m., s.t., Seminar Room of the Hans Borst Centre, building I11) Peter Mombaerts, M.D., Ph.D., Director, Department of Molecular Neurogenetics, Max Planck Institute of Biophysics, Frankfurt am Main: Coding Olfaction 20.03.2012 (6 p.m., c.t., Lecture Hall N) Prof. Ernst Stelzer, PhD, Physical Biology, BMLS, Goethe University, Frankfurt am Main: Light Sheet-based Fluorescence Microscopy (LSFM) reduces Phototoxic Effects providing new Means for Modern Life Sciences Prof. Achim Gossler, PhD, Institute for Molecular Biology, Hannover Medical School, Hannover: Regulation of cilia formation, function and positioning in the early mouse embryo 12.03.2012, Special lecture (6 p.m., s.t., Seminar Room Hans Borst Centre in the building I11) Noriyuki Kasahara, MD PhD, Professor, Departments of Medicine and Molecular & Medical Pharmacology, Director, JCCC Vector Shared Resource & CURE Vector Core Facility, University of California, Los Angeles (UCLA), President, International Society for Cell & Gene Therapy of Cancer (ISCGT), UCLA David Geffen School of Medicine: Translational development of novel therapies at the interface of cancer, transplantation, and regenerative medicine: Light at the end of the tunnel? 12.03.2012, Special lecture (11 a.m., s.t., lecture hall G) Prof. Dr. Markus Aebi, Department of Microbiology, ETH Zurich: Mechanisms and principles of Nlinked protein glycosylation 11.01.2012 (6 pm c.t., Lecture Hall M) Prof. Sabine Kloth, PhD, TÜV SÜD AG, München: Anforderungen an das Risikomanagement und die biologische Sicherheit Zell-basierter Produkte: Europäische und internationale Initiativen Thomas Breymann, MD, Dept. of Cardiothoracic, Transplantation and Vascular Surgery, Hannover Medical School, Hannover: Tissue engineered heart valves – first clinical results 14.12.2011(4 pm c.t., Lecture Hall G) Prof. Dr. Sarah Ferber, MD PhD, Centre for Stem Cells, Regenerative Medicine and Tissue Engineering, Sheba Medical Center, Tel Hashomer, Israel and Dpt. of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel-Aviv University: Cell replacement therapy for diabetes: direct reprogramming of human adult cells into insulin producing cells 09.11.2011 (6 pm c.t., Lecture Hall M) Dagmar Wirth, PhD, Model Systems for Infection and Immunity, Helmholtz Centre for Infection Research, Braunschweig: Rational engineering of cells and mice Prof. Andreas Günther, MD, Dept. of Internal Medicine II, University of Giessen Lung Center, Giessen: Chronic alveolar epithelial cell injury as underlying principle in lung fibrosis 13.10.2011, Special lecture (1.00 pm c.t., Seminar Room of the Institute of Cell and Molecular Pathology, Building I6, Level 01, Room 2013) Sabine Mai, BSc, MSc, PhD, Director, The Genomic Centre for Cancer Research and Diagnosis (GCCRD), University of Manitoba, Winnipeg, Canada: Nuclear architecture, genomic instability and cancer 12.10.2011, Special lecture (lecture hall C, 6 pm c.t.) Prof. Gerald Schumann, PhD, Dept. of Medical Biotechnology, Paul-Ehrlich-Institut, Federal Institute for Vaccines and Biomedicines, Langen LINE1-mediated retrotransposition in human pluripotent stem cells: Reprogramming induces reactivation of LINE-1 31.08.2011, Special lecture (lecture hall N, 17 pm c.t.) Teruo Okano, PhD, Professor and Director, Institute of Advanced Biomedical Engineering and Science (Tokyo Women‘s Medical University, Japan) Cell Sheet Tissue Engineering 12.07.2011, Special lecture (lecture hall B, 4.00 pm c.t.) Neal S. Young, MD, Chief, Hematology Branch, National Heart, Lung and Blood Institute, National Institute of Health (NIH), Bethesda, MD, USA: Aplastic anemia, telomere attrition, and the new telomeropathies 17.06.2011, Special lecture (11.00 am c.t., in building I11, HBZ, seminar room 6040) Steve Watson, PhD, FMedSci, BHF Professor in Cardiovascular Sciences and Cellular Pharmacology, University of Birmingham, England: Critical role of platelets in lymphatic development 06.06.2011, Special lecture of the Cluster of Excellence REBIRTH in cooperation with the HTTG's Scientific Afternoon (4 pm c.t., lecture hall N) Prof. Gaetano Thiene, MD, Hon FRCP (London), University of Padua Medical School, Padua, Italy: THE BICUSPID AORTIC VALVE SYNDROME Peter Miethe, PhD, Managing Director, Forschungszentrum für Medizintechnik und Biotechnologie, Bad Langensalza, Germany: BACTERIA CELLULOSE AND CELLULOSE DERIVATIVE CHEMISTRY AS TOOLS FOR CELL AND TISSUE ENGINEERING 12.05.2011, Special Lecture: Induced Totipotency (6 pm, c.t., lecture hall M) Tobias Cantz, REBIRTH Junior Research Group Stem Cell Biology, Hannover Medical School: Viable mice generated directly from induced pluripotent stem cells Hans-Georg Dederer, Professor of Constitutional and Administrative Law, Public International Law, European and International Economic Law, University of Passau: Patentability of inventions in the field of hESC-research at the crossroads: Brüstle vs. Greenpeace, Annotations to the EU Advocate General's opinion of March 10, 2011 11.05.2011 (5 pm, s.t., lecture hall G) Prof. Hugues Abriel, MD, PhD, Director, Departement of Clinical Research University of Bern, Switzerland: Cardiac channelopathies: the case of the cardiac sodium channel Nav1.5 10.05.2011(6 pm, c.t., lecture hall M) Dr. Sotirios Korossis, PhD, Institute of Medical & Biological Engineering, University of Leeds: Regeneration through Modeling and Simulation: the Future of Mitral Valve Repair Prof. Dr. Theresia Kraft, Institute for Molecular- and Cellphysiology, Hannover Medical School: What can we learn about pathogenic mechanisms in Familial Hypertrophic Cardiomyopathy by studying patient's cardiomyocytes? 19.04.2011, special lecture (6 pm s.t., lecture room of the Institute for Multiphase Processes, Callinstr. 36, Hannover) Denys Pogozhykh, PhD, Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine: Clinical Application of Low Temperatures 24.03.2011 (5 pm, lecture hall B, building I2) Dr. Lilia Kuleshova, Melbourne, Australia New Strategy for Cryopreservation of Stem Cells, Native and Engineered Tissues 26.01.2011, (6 p.m.,c.t., lecture hall G) Prof. Martijn van Griensven, MD, PhD, Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Austrian Cluster for Tissue Regeneration, Vienna/Austria: Stem cells, growth factors and natural biomaterials for bone engineering Prof. Roland Jacobs, PhD, Clinic for Immunology and Rheumatology, Hannover Medical School: Immunosuppression of natural killer cells mediated by umbilical cord-derived mesenchymal stem cells (UC-MSC) 08.12.2010, Special lecture (5 pm, c.t., building J1, lecture hall G) Miguel A. Esteban, Professor, South China Institute of Stem Cell & Regenerative Medicine, Guangzhou Institute of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS): Mechanisms of nuclear reprogramming with exogenous factors and disease modelling 22.11.2010, Special lecture (1.15 p.m., s.t., Gr. Seminarraum, Laser Zentrum Hannover, Hollerithallee 8, Hannover) Prof. Fumitaka Mafuné, Univ. of Tokio, Japan Fundamentals of Laser Nanosurgery: Degradation of proteins in the nano-reaction field caused by resonant photoexcitation of gold nanoparticles 05.11.2010, Special lecture (12:00 c.t., Seminarraum - TPFZ I11-SO-1420) Dieter C. Gruenert, Ph.D., Professor - Dept. of Otolaryngology, University of California, San Fransisco: "Modification of Genomic HPRT, CFTR, and β-globin, in Somatic and Pluripotent Cells by SFHR" 03.11.2010, (6.00 p.m., c.t., lecture hall N) Dirk Strunk, MD, Stem Cell Research Unit and Dept. of Hematology & Stem Cell Transplantation, Medical University of Graz, Austria: Therapeutic vasculogenesis in vivo by co-transplantation of human endothelial and mesenchymal progenitor cells Professor Ulrich Kalinke, PhD, Managing Director TWINCORE, Centre for Experimental and Clinical Infection Research, Hannover: Function of virus-induced type I IFN in periphery and brain 02.11.2010, Special lecture (6.00 p.m.,c.t., building J1, lecture hall N) Martin Bastmeyer, Professor, Karlsruhe Institute for Technology (KIT), Zoological Institute, Cell- and Neurobiology: Tailored Three-dimensional Microstructure Scaffolds for Cell Culture Studies 20.10.2010 (4.00 pm, s.t., lecture hall M) Prof. Dr. Alexander Heisterkamp, Abt. Biomed. Optik, Biophotonik, Laser Zentrum Hannover: Innovation im Laser-gestützten Imaging für das Tissue Engineering Prof. Dr. Mathias Ochs, Institut für Funktionelle und Angewandte Anatomie, MHH: Ultrastrukturanalyse mit Elektronenmikroskopie und Stereologie Prof. Dr. Bodo Rosenhahn, Institut für Informationsverarbeitung, Leibniz Universität Hannover: Bildinterpretation zur automatisierten Zell- und Gewebeanalyse 14.10.2010, Special lecture (1.00 pm, c.t., Gr. Seminarraum, Laser Zentrum Hannover) Prof. Francesco Stellacci, Associate Professor Paul M. Cook, Dept of Materials Science and Engineering, MIT, Cambridge, USA: Cell Membrane Penetrating Particles for RNA Delivery 04.10.2010, Special lecture (lecture hall G, 5.00 p.m s.t.) Beat H. Walpoth, MD, PD, FAHA Director, Cardiovascular Research, Service of Cardiovascular Surgery, Geneva University Hospital, Geneva, Switzerland Non-cell-based Vascular Tissue Engineering 27.09.2010, Special lecture (5.00 p.m. s.t., seminar room 30, K05, level 02) Michael J. Pencina, PhD, Harvard Clinical Research Institute, Boston University: Issues in developing and improving risk prediction models 22.09.2010, Special lecture (6.00 pm, c.t., building J1, lecture hall N) Alberto Saiani, PhD, Senior Lecturer in Materials Characterisation, School of Materials, University of Manchester, UK: Designing functional biomaterials exploiting peptide self-assembly 20.09.2010, Special lecture (5.00 pm, s.t., building J1, lecture hall H) Michelle Tallquist, Ph.D., University of Texas, Southwestern Medical Center, Dallas: Genetic regulation of coronary vascular smooth muscle and cardiac fibroblasts 15.09.2010, Special lecture (6.00 pm, s.t., building J1, lecture hall N) Dr. Carl-Philipp Heisenberg, Max-Planck-Institute of Molecular Cell Biology and Genetics, Dresden: Cell and Tissue Mechanics in Zebrafish Gastrulation 07.09.2010, Special lecture (2.00 pm , s.t., building J1, lecture hall N) Mauro Giacca, MD, PhD, Director, International Centre for Genetic Engineering and Biotechnology, Trieste, Italy: AAV Gene Transfer in Small and Large Animal Models of Cardiovascular Disease 09.09.2010, Special lecture (6.00 pm, c.t., building J1, lecture hall N) Nicholas R. Forsyth, PhD, Institute for Science & Technology in Medicine, Guy Hilton Research Centre, Keele University, Staffordshire, UK: Hypoxia - Implications of Physical Normoxia for Stem Cell Cultivation and Tissue Engineering 25.08.2010, Special lecture (6.00 pm, c.t., building J1, lecture hall N) Frank Gunn-Moore, PhD, BSc, School of Biology, North Haugh University of St Andrews Fife, Scotland, UK: Making Light Deliver: Using Lasers to Guide and Transfect Mammalian Cells 19.08.2010, Special lecture (6.00 pm, c.t., building J1, lecture hall N) Prof. Ken Suzuki, Dept. of Translational Cardiovascular Therapeutics, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London: Cell Transplantation for Heart Failure 06.08.2010, Special lecture (1.00 p.m.,c.t.,lecture hall N) Prof. Guoliang Xu, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China: Role of DNA methylation in development 28.07.2010, Special lecture (12.00 noon, s.t., building J6, level 01, seminar room Institute of Cellular and Molecular Pathology) Prof. Konstanze Döhner, University Hospital of Ulm, Department of Internal Medicine III: Genetics in acute myeloid leukemia 08.07.2010, Special lecture (6:00 p.m.,c.t., lecture hall G) Juan A. Bueren, Ph.D., Head of the Hematopoietic Gene Therapy Division, CIEMAT, Madrid, Spain: Gene Therapy and Cell Reprogramming in Fanconi Anemia 21.06.2010, Special lecture (5:00 p.m., s .t., lecture hall G) Ziad Mallat, MD, PhD, Director of Research at INSERM, Paris, France: Regulatory T-Cell Immunity in Atherosclerosis 22.06.2010, (3.00 p.m.,c.t., lecture hall C) Prof. Sonja Schrepfer, University Heart Center Hamburg, Transplant and Stem Cell Immunobiology Lab (TSI), Hamburg: Genetically-engineered low-antigenicity MHC I knockdown human embryonic stem cells to escape T cell response Dr. Jörg Heineke, Dept. of Cardiology and Angiology, Hannover Medical School 21.06.2010, Special lecture (4.00 p.m., s.t., lecture hall H) Dr. Alexey V. Pshezhetsky, PhD, Departments of Pediatrics and Biochemistry, University of Montreal, Canada: 'New role of the old enzyme: neuraminidase 1 as a modulator of cell signaling' 03.06.2010, Special lecture (1:15 pm, s.t., Laser Zentrum Hannover, Hollerithallee 8, 30419 Hanover, Großer Seminarraum) Prof. Michel Meunier, Department of Engineering Physics, Ecole Polytechnique de Montreal, Canada: Ultrafast laser applications in processing biomedical nanoparticles and cell nanosurgery 01.06.2010, Special lecture ( 6.00 pm, c.t., building J6, lecture hall Q) Farzin Farzaneh, PhD, and Lucas Chan, PhD, Rayne Cell Therapy Suite (MA IMP), Department of Haematological Medicine, King's College London School of Medicine, London, UK: Autologous lentiviral transduced CD80/IL-2 expressing leukemic blasts for immune gene therapy of AML 27.05.2010, Special lecture ( 2.00 pm, s.t., building J1, lecture hall N) Dr. Katja Schenke-Layland, Fraunhofer Institute for Interfacial Engineering and Biotechnology, Dept of Cell and Tissue Engineering, Stuttgart: Impact of Extracellular Matrix in Biomedical Research 26.05.2010, Special lecture (6.00 pm, s.t., building J1, lecture hall G) Prof. Niels-Bjarne Woods, Molecular Medicine and Gene Therapy, Lund Strategic Center for Stem Cell Biologie and Cell Therapy, Lund University, Sweden: Human Embryonic Stem Cell and Induced Pluripotent Stem Cell Differentiation to Hematopoietic Stem and Progenitor Cells 20.05.2010, Special lecture (6.00 pm, s.t., in building J1, lecture hall N) Dr. Ulrike G. K. Wegst, Drexel University, Department of Materials Science and Engineering, Philadelphia, USA: Biological Materials, Biomaterials and Biomimetics 29.04.2010, Special lecture (6.00 pm, c.t., lecture hall G) Prof. Gregory R.D. Evans, MD, FACS, Aesthetic and Plastic Surgery Institute, University of California, Irvine/CA: Tissue Engineering in Plastic Surgery 28.04.2010, Special lecture (5.00 pm, s.t., building I3, room 1280, level 4) Dr. Dirk Lefeber, Dept of Laboratory Medicine, Laboratory of Genetic Endocrine and Metabolic Disease, Radboud University Nijmegen Medical Centre: Disorders of the secretory pathway: lessons from genetic glycosylation defects 15.04.2010 (6.15 pm, lecture hall HS H) Lynn Enquist, Department of Molecular Biology, University of Princeton, USA: Studying mechanisms of spread of herpesvirus infection in peripheral nervous system neurons 23.03.2010, Special lecture ( 5.00 pm, s.t., lecture hall G) Kenneth Walsh, Ph.D., Director, Whitaker Cardiovascular Institute, Boston University School of Medicine: Molecular control of body composition and its impact on cardiovascular disease 18.03.2010 Dr. Silke R. Sperling, Max Planck Institute for Molecular Genetics, Cardiovascular Genetics, Berlin: DPF3 a novel epigenetic transcription factor essential for cardiac development and functions Prof. Dr. Beate Sodeik, Institute of Virology, Hannover Medical School: Nuclear targeting of Herpes Simplex Virus Vectors 18.02.2010, Special lecture (2.00 pm, s.t., lecture hall G) Prof. Andrea Robitzki, Centre for Biotechnology and Biomedicine (BBZ), University of Leipzig: Biochip-based High Content Screening and Real-time Monitoring of Viable Cells and Organotypic Tissues 04.02.2010, Special lecture (6.30 pm, s.t., lecture hall N) Peter C. Johnson, MD, President and CEO Scintellix and Chief Editor 'Tissue Engineering', Raleigh, North Carolina/USA: Strategic Directions in Tissue Engineering 14.01.2010, (6 pm, c.t., lecture hall N) Dr. Simone Hess / Dr. Anna Katrin Dinkla, Hannover Medical School: How to get money from the EU - Funding for research in the 7th Framework Programme 30.11.2009, Special lecture (5 pm, s.t., lecture hall H, J1, level H0) Michael Potente, Institute for Cardiovascular Regeneration, Centre of Molecular Medicine & Department of Cardiology Internal Medicine III, Goethe University Frankfurt SIRT1 – A novel regulator of Angiogenesis (Control of vascular homeostasis and blood vessel growth by the SIRT1 deacetylase) 12.11.2009, Special lecture (12 am s.t., HBZ (Hans Borst Center)-K11, Seminar Room 6040) Prof. Dr. Matthew D. Weitzman, The Salk Institute for Biological Studies La Jolla, California, USA: Cellular Recognition and Restriction of Viruses and Vectors 13.10.2009, Special lecture (10.30 am s.t., Hotel Mercure, Karl-Wiechert-Allee 68, Hannover) Christian Kratz, National Institute of Health/National Cancer Institute, Rockville, MD, USA: MDS/AML in individuals with underlying genetic predispositions 28.09.2009, (5 pm s.t., seminar room 30, K5, level 2, lift group D) Martin Bergmann, Asklepios Klinik St. Georg, Hamburg: Role of Wnt signaling for embryonic heart development and adult myocardial regeneration 24.09.2009 (6 pm c.t., lecture hall H) Dr.-Ing. Stephan Barcikowski, Dept. Nanotechnology, Laser Centre Hannover: Design of Nano-Markers for Drug Targeting Prof. Dr. Joachim Spatz, Max Planck Institute for Metals Research, Stuttgart: Mechano-Responsive Synthetic Cell Environments 27.08.09 Special lecture (5 pm, s.t., seminar room S30, building K5, liftgroup D, level 2) Loren J. Field, PhD, Riley Heart Research Center, Indiana University School of Medicine, Indianapolis/USA: Mechanisms of Cardiac Repair 06.07.2009, Special lecture (6 pm c.t., lecture hall H) Eric S. Hayes, Ph.D., Head Reproductive Biology, University of Washington, Seattle: Twins, Chimeras and Stem Cells: Nonhuman Primate Models for Biomedical Research 30.06.2009, Special lecture (6 pm c.t., seminar room 6040, K11-HBZ-S0) Prof J. Escher, Leibniz Universität Hannover, Institute for Applied Mathematics: Modeling and Analysis of Tumor Growth 22.06.2009, Special lecture (5 pm s.t., lecture hall H) Paul Riley Ph.D., BSc, University College London, GB: The Epicardium as a Source for Cardiovascular Regeneration 04.06.09, (6 p.m. c.t., lecture hall N) Dr. Martin Zenke, Helmholtz Institute for Biomedical Engineering, Department of Cell Biology, Aachen: Stem Cells, Biomaterials and Nanoparticles Dr. Anneke Loos, Hannover Medical School, BioMedimplant, Hannover: The Way from bench to bedside from a regulatory point of view: the medical device approval process 25.05.09, Special lecture (5 pm s.t., lecture hall H) Wolfram Zimmermann M.D. , Head, Dept of Pharmacology, Georg-August-University of Göttingen: Parthenogenesis as a novel source of pluripotent stem cells 16.04.2009, (6 p.m. c.t., lecture hall N) PD Dr. Frank Edenhofer, University of Bonn, Institute of Reconstructive Neurobiology, Stem Cell Engineering Group: Exploring non-genetic pathways to induce pluripotency Dr. Lars Zender, Hannover Medical School, Dep. of Gastroenterology, Hepatology and Endocrinology and Helmholtz Centre for Infection Research, Braunschweig: In vivo RNAi screening to dissect signaling pathways in liver cancer and liver regeneration 02.04.2009, Special lecture (6.00 pm c.t., lecture hall N) Dr. Mathias Oelke, Dept. of Pathology, Johns Hopkins University School of Medicine, Baltimore MA: The ABCs of aAPC: Artificial Antigen Presenting Cells - From Activation to Depletion 09.03.2009, Special lecture (5.00 pm s.t., seminar room S30, K5-02, lift group D) Dr. Arnd Siekmann, Max-Planck-Institut für molekulare Biomedizin, Münster: The vascular big bang: Dissecting the origins of vascular patterning 06.03.2009, Special lecture (11.30 am s.t., lecture hall M) Dr. Greg Cost, Sangamo Biosciences Inc., Richmond CA, USA: Genetic Engineering in Mammals and in Mammalian Cells using Zinc-finger Nucleases 17.02.09 (5.30 p.m., room R226, Institute of Multiphase Processes, Leibniz University of Hannover) Prof. Dr. Gerhard Rakhorst, University Medical Center Groningen, NL, Dept. of BioMedical Engineering: Animal Experiments in Biomedical Engineering and New Techniques to Improve the Quality of Donor Organs 12.02.09 (6 p.m., Lecture hall N) Dr. Timm Schröder, Institute of Stem Cell Research, Helmholtz Zentrum Muenchen: Tracking stem cells at the single cell level: New tools for old questions 15.01.2009, Special lecture (6 p.m. c.t., Lecture hall N) Dr. Jason Acker, Research & Development, Canadian Blood Services, Department of Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada Advances in Red Blood Cell Preservation 16.12.2008 , Special lecture (4 p.m. c.t., Hans-Borst-Zentrum, ground floor, Seminar room 6040) PD Dr. Manfred Jücker, Zentrum für Experimentelle Medizin, Institut für Biochemie und Molekularbiologie I, Universitätsklinikum Hamburg-Eppendorf: Effects of SHIP on PI3-Kinase/Akt signaling in human leukemia cells 10.12.2008, Special lecture (6 p.m. c.t., lecture hall E) Andreas Sputtik, Institut für Transfusionsmedizin, Univ.-Klinikum Hamburg-Eppendorf: Some like it cold. How Peripheral Blood Stem Cells Survive Cryopreservation 04.12.2008 (6 p.m. c.t., lecture hall N) Prof. Dr. Bernd K. Fleischmann, Institute of Physiology І, Life & Brain Centre, University of Bonn: Potential and pitfalls of cellular replacement approaches in the heart Dr. Marcus Furch, Institute for Biophysical Chemistry, Hannover Medical School: Target-directed Drug Design in Regenerative Medicine 24.11.08, Special lecture ( 1 p.m., K11-TPFZ building, Room SO-1420) Thomas Woelfel, Prof. Dr. med., Dept. of Hematology and Oncology, University Hospital Mainz: Molecular analysis of the anti-tumor T cell repertoire in melanoma patients 30.10.2008, Special lecture (6 p.m. s.t., lecture hall M) Renate Koenig, Burnham Institute for Medical Research, La Jolla/USA Global Analysis of host pathogen interactions that regulate early stage HIV-1-replication 20.10.08, Special lecture, (6 p.m. s.t., lecture hall G) David Stout, PhD, Director of the Crump Institute for Preclinical Molecular Imaging Faculty, University of California, Los Angeles (UCLA): Imaging Center Design 20.10.08, Special lecture, (12 p.m. s.t., lecture hall G) David Stout, PhD, Director of the Crump Institute for Preclinical Molecular Imaging Faculty, University of California, Los Angeles (UCLA): Animal Models of Imaging Disease 06.10.2008, Special lecture (5 p.m. s.t., seminar room 30, K5, level 2) M. Nahrendorf, MD, PhD, Massachusetts General Hospital, Harvard Medical School, Boston MA: Molecular Imaging in Cardiovascular Injury and Repair 06.10.2008, Special lecture ( 5.30 p.m. s.t., seminar room "Hans-Borst-Zentrum", ground floor, room 6040 ) Professor Dr. Christian Buske, Klinikum Großhadern & Helmholtz Zentrum München: Leukemic stem Cells with lymphoid characteristics in AML 17.09.2008, Special Lecture (5 p.m. lecture hall Q) Dr. Manfred Wuhrer, Department of Parasitology, Centre for Infectious Diseases, LUMC (Leids Universitair Medisch Centrum), Leiden, NL: Mass spectrometry-based glycomics and glycan microarrays: clinical applications 28.08.2008, Special lecture (6 p.m. s.t. , lecture hall M) PD Dr. Wolfgang Herr, DFG Clinical Research Group 183 'Optimized Allogeneic Lymphocyte Therapy', University Hospital Mainz: Towards specific T cell therapy in acute leukemia 27.08.2008, Special lecture (6 p.m. s.t., lecture hall M) Prof. Hans-Peter Kiem, Fred Hutchinson Cancer Research Center, University of Washington School of Medicine: Hematopoietic Stem Cell Gene Therapy: Efficacy and Safety in Large Animal Models 26.08.2008, Special lecture (6 p.m. s.t., lecture hall M) Dr. Claudia Mitchell, Institut Cochin, Genetic and Development Department, Paris: Liver regeneration: progressing through the cell cycle 21.08.2008, Special lecture (5 p.m. s.t., lecture hall G) Dr. Joe Tiralongo, Griffith University, Australia, Institute for Glycomics, Gold Coast Campus: Role of carbohydrates in disease: Focus on cancer progression and microbial pathogenesis 14.08.2008, Special lecture (5 p.m. s.t., lecture hall G) Prof. Hisashi Narimatsu, Research Center for Medical Glycoscience (RCMG), National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan: Development of advanced technology and its application to discover cancer glyco-biomarkers 23.06.2008, Special lecture (5 pm c.t., lecture hall B) Prof. Dr. Freddy Radtke, Swiss Institute for Experimental Cancer Research (ISREC), Epalinges, Switzerland: Notch Signaling in Cell Fate Decisions 20.06.2008, Special lecture (18.00 Uhr s.t., Hörsaal N der MHH) PD Dr. Gerald Schumann, Paul-Ehrlich-Institut, Langen: Intracellular defense against human LINE-1 retrotransposition 19.06.2008 Special Lecture (18 Uhr s.t., Hörsaal N der MHH) Dr. Sebastian Carotta, The Walter and Eliza Hall Intitute of Medical Research, Immunology Division, Melbourne: PU.1 and IRF-8 suppress the formation of B cell leukemia 18.06.2008 Special Lecture (17 Uhr s.t., Hörsaal M der MHH) Dr. Robert Zweigerdt, Institute of Medical Biology (IMB), Singapore: Mending broken hearts - harnessing the potential of human embryonic stem cell derived cardiomyocytes 05.06.2008 Prof. Dr. Beate Sodeik, Institute of Virology, MHH: How viral vectors negotiate their way to deliver their therapeutic message to the host nucleus Dr. Michael Bock, Dept. of Gastroenterology, Hepatology and Endocrinology, MHH: Murine and Human Hepatocytes for Transplantation 22.05.2008, Special lecture (18.00 Uhr s.t., Hörsal N der MHH) Dr. Matthias W. Hentze, Associate Director, European Molecular Biology Laboratory (EMBL), Heidelberg: Understanding metabolic regulatory networks: iron metabolism and its diseases 20.05.2008, Special lecture (18.00 Uhr c.t., Hörsaal G der MHH) Prof. Moshe Flugelman, Lady Davis Carmel Medical Center, Dept. of Cardiovascular Medicine, Haifa/Israel: Engineering blood vessels by gene and cell therapy 19.05.2008 Special lecture (17:15 Uhr, Seminarraum S30, K5, 2. Stock, Knoten D) Dr. Christian Kupatt, MD, Medizinische Klinik und Poliklinik I, Klinikum Großhadern, München: Myokardprotektion durch parakrine Effekte endothelialer Progenitorzellen: Rolle des Thymosin beta4 28.04.2008, Special lecture (18:00 Uhr s.t., Hörsaal N der MHH) Dr. Robert David, Medizinische Klinik und Poliklinik 1 der LMU, München Großhadern: MesP1 induces vertebrate cardiovascular differentiation by Dkk-1 driven inhibition of wnt-signaling 22.05.2008, Special lecture (18.00 Uhr s.t., Hörsaal N der MHH) Dr. Matthias W. Hentze, Associate Director, European Molecular Biology Laboratory (EMBL), Heidelberg: Understanding metabolic regulatory networks: iron metabolism and its diseases 17.04.2008, Special lecture (18.30 Uhr s.t., Institut für Mehrphasenprozesse der Leibniz-Universität Hannover, Callinstr. 36, Seminarraum) Dr. John C. Bischof, Mechanical Engineering, University of Minnesota, Minneapolis/MN, USA: Gold and Magnetic Nanoparticles for Biothermal Disease Treatment 10.04.2008 Dr. Michel Pucéat, French National Institute of Health and Medical Research INSERM, Evry, Frankreich: Epigenetic and genetic regulation of cardiac commitment of Primate Embryonic stem cells and preclinical studies in a primate model of heart disease Dr. Christina Mauritz, Leibniz Forschungslaboratorien für Biotechnologie und künstliche Organe, MHH: Generation of functional murine cardiac myocytes from induced pluripotent stem (iPS) cells 02.04.2008, Special lecture (11.00 Uhr s.t., Hörsaal N) Dr. Shai Izraeli, Head, Research section, pediatric Hemato-Oncology Cancer Center, Sheba Medical Center Tel-Hashomer, Ramat Gan, Israel: Megakaryocytic differentiation and leukemic transformation of fetal hematopoietic stem cells - the role of the ERG gene 28.02.2008, Special lecture (18.00 Uhr s.t., Hörsaal N) Prof. Mavrilas, Biomedical Engineering Laboratory, Dep. Mechanical Engineering & Aeronautics, University of Patras/Griechenland, An approach to biomechanical modelling clinical treatment 14.02.2008 Dr. Tobias Cantz, Max Planck Institute for Molecular Biomedicine, Dept. Cell and Developmental Biology, Münster: Pluripotency and Differentiation Analyses of Reprogrammed Somatic Cells Prof. Jörn Bullerdiek, Zentrum für Humangenetik Bremen, Universität Bremen: Nuclear programming of HMGA proteins 7.02.2008, Special lecture (18.00 Uhr s.t., Hörsaal M) Dr. Oertel, Albert Einstein College of Medicine, New York/USA Liver repopulation after cell transplantation: Fetal liver stem/progenitor cells win the competition 17.01.2008, Special lecture (17.00 Uhr c.t., Hörsaal H) Prof. Jürgen Roth, Division of Cell and Molecular Pathology, University of Zurich, Zurich/Switzerland, Quality Control of Protein Folding and Protein Folding Diseases 13.12.07 Dr. Holm Zaehres, Max Planck Institute for Molecular Biomedicine, Dept. Cell and Developmental Biology, Münster: Transcription Factor - Induced Pluripotency Dr. Christian Hess, Leibniz Research Laboratories for Biotechnology and Artificial Organs, MHH: Von der Kunstlunge zum biologischen Lungenersatz 04.12.2007, Special lecture (17.00 Uhr, Hörsaal G) Prof. Farzin Farzaneh, Dept. Haematological Medicine, King's College, London: High titre retroviral vectors for the functional analysis of the genome and immune gene therapy of poor prognosis acute myeloid leukaemia 04.12.2007, Special lecture (12.15 Uhr, Hörsaal N) Prof. Georg Füllen, Ernst Moritz Arndt Universität Greifswald: Stem Cells, Ageing, lots of Data - how could Bioinformatics help Rebirth and other MHH/LUH Projects? 26.11.2007, Special lecture (15.45 Uhr, Hörsaal N) Dr. Allison Hubel, Mechanical Engineering, University of Minnesota, Minneapolis/MN, USA: Cryopreservation of stem cells 12.11.2007, Special lecture (18.00 Uhr, Hörsaal N) Dr. Manfred Gossen, Max-Delbrück-Center for Molecular Medicine, Berlin: Functional autonomy of transgenic transcription units 08.11.2007 Prof. Dr. Alexander Heisterkamp, Dept. of Biomedical Optics, Laser Centre Hannover e.V.: Cellular Imaging and Manipulation by Laser Radiaton Prof. Dr. Jürgen Borlak, Fraunhofer Institute of Toxicology and Experimental Medicine: A toolbox of enabling technologies: possibilities for collaborations with the molecular toxicology unit of REBIRTH 11.10.2007, Special lecture (18.00 Uhr, Hörsaal N) Prof. Dr. Wolfgang Schaper, Max-Planck-Institut für Herz- und Lungenforschung, Bad Nauheim: Mechanisms of postnatal arteriogenesis and vascular regeneration 11.09.2007, Special lecture (14.00 Uhr c.t., Hörsaal des Instituts für Tierzucht, FAL Mariensee „Konferenzhaus Pferdestall“) Dr. Tobias Brambrink, Whitehead Institute for Biomedical Research, Cambridge, MA, USA : Restoration of pluripotency in somatic cells by genetic manipulation: Facts, Fiction and Future 13.07.2007, Special lecture (15.00 Uhr, Hörsaal N) Dr. Harald Ott, Department of Surgery , Massachusetts General Hospital, Boston: Building a Bioartificial Heart - Initial Results Based on Nature´s Own Platform 09.07.2007, Special lecture (18.00 Uhr, Hörsaal N ) Prof. Graham Lieschke, Walter and Eliza Hall Institute of Medical Research, Cancer and Haematology Division Melbourne, Australia: Zebrafish myeloid mutants point to new pathways regulating hematopoietic development 27.06.2007, Special lecture (18.00 Uhr, Hörsaal N) Prof. Hans Stauss, University College London, Royal Free Hospital, Department of Immunology and Molecular Pathology TCR gene therapy of tumours 20.06.2007, Special lecture (17.00 Uhr, Hörsaal N) Pauline Rudd, Dublin-Oxford Glycobiology Laboratory, National Institute for Bioprocessing Research and Training, Conway Institute, University College Dublin Belfield The impact of glycosylationon the biological function and structure of immunoglobulins 14.06.2007 PD Dr. M. Bergmann, Franz-Volhard Klinik am MDC, Charité Campus Buch: Myokard-spezifische Bedeutung von Beta-catenin bei Reparaturprozessen im adulten Herzen Prof. Dr. Theresia Kraft, Molekular- und Zellphysiologie, MHH: Familial Hypertrophic Cardiomyopathy: Functional effects of point mutations studied in isolated cardiomyocytes 07.06.2007 Special lecture (18.00 Uhr, Hörsaal G) Loren J. Field, Indiana University School of Medicine, Indiana New developments in cardiac regeneration strategies: Cell transplantation vs. cell cycle regulation 07.06.2007, Special lecture (17.00 Uhr , Hörsaal H) Erika Sasaki, Central Institute for Experimental Animals (CIEA), Division of Laboratory Animal Science, Kawasaki, Japan Novel Primate Embryonic Stem Cell Lines: Establishment and Characterization 07.06.2007, Special lecture (17.00 Uhr, Hörsaal H) Erika Sasaki, Central Institute for Experimental Animals (CIEA), Division of Laboratory Animal Science, Kawasaki, Japan Novel Primate Embryonic Stem Cell Lines: Establishment and Characterization 07.05.2007 Special lecture (13.00 Uhr, Hörsaal M) James Ellis, Hospital for sick children MaRS Centre, Toronto, Canada Epigenetics of retrovirus silencing and variegation in stem cells 03.05.2007 Special lecture (18.00 Uhr, Hörsaal G) Sebastian Brenner, Department of Pediatrics, University Clinic Dresden Homing and Engraftment of Hematopoietic Stem Cells: Implications for Gene Therapy 12.04.2007 Dr. T. Saric, Institut für Neurophysiologie, Universität Köln Molecular basis of immune privilege of murine embryonic stem cells Dr.-Ing. S. Barcikowski, Dept. Nanotechnology, Laser Centre Hannover: Nanoparticles and Nanomaterials for Biomedical Applications 08.02.2007 Prof. Dr. Juergen Bode, Helmholtz Zentrum für Infektionsforschung, Braunschweig: Chromosome-based Expression Systems: Origin, Applications and Performance 10.08.2006 Dr. A. Emmendörffer, euroderm GmbH, Leipzig: Hair follicles as stem cell source - Clinical use of outer rooth sheath cells for generation of artificial epidermis Prof. A. Kispert, Molekularbiologie, MHH: T-Box genes in cardiac development 08.06.2006 Dr. U. Gehling, Klinik für Hepatobiliäre Chirurgie und Viszerale Transplantation, Universitätsklinikum Hamburg-Eppendorf: Stammzellen zur Leberregeneration Dr. D. Hilfiker-Kleiner, Abt. Kardiologie, MHH: Postpartum Kardiomyopathie: Prolaktin und die dunkle Seite der Macht 06.04.2006 Dr. Ch. Radtke, Klinik für Plastische-, Hand- und Wiederherstellungschirurgie, MHH: Cell transplantation of peripheral-myelin-forming cells to repair the injured spinal cord Prof. Dr. A. Seltsam, Transfusionsmedizin, MHH: Regulating MHC expression for cellular therapeutics 24.03.2006, Special Lecture Shin-Ichi Nishikawa, MD/PhD, Riken Center For Developmental Biology, Kobe, Japan: Gene discovery by a DNA microarray data base of ES cell differentiation and stem cells 16.02.2006 Dr. Ch. Templin, Abt. Kardiologie, MHH: Verbesserung der kardialen Funktion im murinen Ischämie/Reperfusionsmodell durch eine mittels retroviraler Transduktion von ß-catenin neu generierten multipotenten hämatopoetischen Progenitorzelllinie Dr. N. Malek, Abt. Gastroenterologie, Hepatologie und Endokrinologie, MHH: Die Funktion von Cyclinen und Cyclin Kinase Inhibitoren in der Regulation der Leberzellproliferation 08.12.2005 Prof. Dr. H.-J. Fehling, Abt. Immunologie, Universität Ulm: "Knock-in" strategies to visualize developmental fates "in vitro" and "in muro" Prof. M. Stojkovic, Institute of Human Genetics, University of Newcastle upon Tyne: Human embryonic stem cells, experiences from UK 13.10.2005 Dr. H. Klump, Abt. Hämatologie / Onkologie, MHH: Converting Embryonic Stem Cells to Blood - HOXB4 mediated Stem Cell Tuning Dr. F. Bahlmann, Nephrologie, MHH: EPO-Therapie, zirkulierende Stammzellen und Progression von Nierenerkrankungen 11.08.2005 Dr. C. Kasper, Institut für Technische Chemie, Universität Hannover: Neue Ansätze zur Gewinnung von Knorpel- und Knochengewebe mittels Tissue Engineering Dr. P. Nayudu, Deutsches Primatenzentrum, Göttingen: First take a good egg - a prerequisite for success with embryo stem cells 16.06.2005 PD Dr. S. Kubicka, Abt. Gastroenterologie, Hepatologie und Endokrinologie, MHH: Virotherapie von Tumoren durch tumorspezifisch replizierende Adenoviren Dr. W. Kues, FAL, Mariensee: Isolation of murine and porcine fetal stem cells from somatic tissue 07.04.2005 M. Iken, Abt. Gastroenterologie, Hepatologie und Endokrinologie, MHH: Evaluierung verschiedener Techniken zur Präservierung von porzinen Pankreata für die nachfolgende Isolierung Langerhansscher Inselzellen PD Dr. D. Schultheiss, Abt. Urologie, MHH: Regenerative Therapien bei Fehlbildungen und Funktionsstörungen des Penis 17.02.2005 Dr. P. Horn, Abt. Transfusionsmedizin, MHH: In vivo Selektion hämatopoetischer Stammzellen Dr. L. Rudolph, Abt. Gastroenterologie, Hepatologie und Endokrinologie, MHH: Telomere shortening and Senescence: Implications for Regeneration, Aging and Cancer 16.12.2004 Prof. M. Kühl, Abt. Biochemie, Universität Ulm: Wnt Signaling During Vertebrate Cardiogenesis Dr. S. Kuci, Päd. Hämatologie und Onkologie, Universität Tübingen: Transdifferenzierungspotential hämatopoetischer CD133+ Stammzellen 21.10.2004 Dr. C. Dammann, Päd. Pneumologie und Neonatologie, MHH: NRG and Erbß Receptors in the Fetal Lung Dr. C. Puschmann, THG-Chirurgie, MHH: Tissue Engineering von Venenklappen 24.06.2004 Dr. Igor M. Sauer, Klinik für Allgemein-, Visceral- und Transplantationschirurgie, Experimentelle Chirurgie, Charité, Berlin: Bioartifizielle extrakorporale Leberunterstützung - Status Quo R. Rohde, LEBAO, MHH: Koronare Magnesiumstents. Ein neues Prinzip zur Vermeidung von Restenosen? 22.04.2004 PD Dr. J. Seufert, Med. Poliklinik Würzburg: Perspektiven der Stammzelltherapie für die Behandlung des Diabetes mellitus Prof. Dr. Ing. J. Lehmann / Dipl.-Biol. S. Niebrügge, Universität Bielefeld, Technische Fakultät: Large-Scale-Zellkultur und Selektion von aus ES-Zellen abgeleiteten Kardiomyozyten im Bioreaktor 26.02.2004 PD Dr. M. Tiedke, Abt. klinische Biochemie, MHH: Gen- und Zelltherapie des Diabetes mellitus Dipl. Biochem. I. Gruh, LEBAO, MHH: "Vom humanen Endothelzell-Vorläufer zur Herzmuskelzelle: Beweise für eine kardiale Differenzierung von EPCs?" 07.01.2004 Dr. K. Weisel, Hämatologie und Onkologie, Universität Tübingen: Aspekte zur Mesodermentwicklung und -differenzierung im Mausmodell 11.12.2003 PD Dr. C. Stamm, Klinik u. Poliklinik für Herzchirurgie, Universität Rostock: Tissue Engineering von AV-Knoten - Ersatzgewebe zur Behandlung des kompletten AV-Blocks PD Dr. K. C. Wollert, Kardiologie u. Angiologie, MHH: Intrakoronare Infusion autologer Knochenmarkzellen nach Myokardinfarkt: Ergebnisse einer prospektiven, randomisierten und kontrollierten klinischen Studie an der MHH 16.10.2003 Dr. Susanne Kall, Klinik für PHW-Chirurgie, Klinikum Oststadt: Tissue Engineering von Sehnen und Bändern Prof. Dr. M. van Griensven, Unfallchirurgie, MHH: Mesenchymale Stammzellen: Quo Vadis? Möglichkeiten der Differenzierung mit chemischen und physiologischen Reizen 28.08.2003 PD Dr. M. Thie, Institut für Anatomie, Universität Essen: In vitro Differenzierungsleistungen einer embryonalen Stammzelllinie von Rhesusaffen (R366.4) PD Dr. U. Martin, LEBAO, MHH: Entwicklung von lentiviralen Vektoren zur zelltypspezifischen Expression von Reporter- und Selektionsgenen 26.06.2003 Dr. rer. nat. Ballmaier, Päd. Hämatologie und Onkologie, MHH: Thrombopoietin - Regulator der Thrombozytenbildung und "Stammzellfaktor" Dr. med. M. Ott, Gastroenterolgoie, MHH: Stand der Stammzellforschung in der Hepatologie 24.04.2003 Prof. Dr. Karin Ulrichs, Chirurgie, Universität Würzburg: Die xenogene Inselzell-Transplantation in der modernen Diabetes-Behandlung. Eine Erfolg versprechende Strategie Dr. med. M. Elsner, Klinische Biochemie, MHH: Gentherapie des Diabetes mellitus mittels viraler Vektorsysteme 13.02.2003 Dr. med. U. Stock, THG-Chirurgie, Universität Jena: Tissue Engineering von Blutgefäßen unter Verwendung biresorbierbarer Polymere Dr. med. T. Walles, THG-Chirurgie, MHH: Mimicking Nature: Biologische Matrices im kardiovaskulären Tissue Engineering 12.12.2002 Dr. med. C. Winkler, Neurologische Klinik, MHH: Charakterisierung neuronaler Stammzellen nach intracerebraler Transplantation in das neonatale und adulte Gehirn Dr. med. J. Großkreutz, Neurologische Klinik, MHH: Funktionelle Charakteristika neuronaler embryonaler Progenitorzellen, die zur Transplantation im experimentellen Parkinson-Modell verwendet werden 24.10.2002 Prof. Dr. S. Dimmeler, Kardiologie der Universität Frankfurt: Regulation und Funktion von Endothelialen Progenitorzellen Prof. Dr. C. Stief, Urologie, MHH: Tissue Engineering zur Schaffung von bioartifiziellen Hohlorganen des Urogenitaltraktes 25.07.2002 Prof. Dr. H. Drexler, Kardiologie und Angiologie, MHH: Transplantation von Knochenmarksstammzellen zur Regeneration von ischämisch geschädigtem Myokard Dr. H. Mertsching, LEBAO, MHH: Einsatz von Endothel-Progenitorzellen zum Tissue Engineering eines Myokard-Patches 13.06.2002 Prof. Dr. H. Haller, Nephrologie, MHH: Untersuchungen zur Regulation der Regeneration renalen Gewebes im Squalus acanthias PD Dr. S. Kubicka, Gastroenterologie und Hepatologie, MHH: Gentherapeutische Strategien zur Hepatozyten-Transplantation und zur Behandlung der regenerativen Dysfunktion bei chronischer Leberschädigung 30.05.2002 Prof. Dr. U. Bosch, Unfallchirurgie, MHH: Tissue Engineering von Röhrenknochen mit stromalen Knochenmarkszellen unter Einsatz einer biologischen Matrix PD Dr. M, Eder /PD Dr. M. Scherr, Abtg. Hämatologie / Onkologie, MHH: Gene Silencing durch si-RNA in hämatologischen Stammzellen 04.04.2002 Dr. A. Niederbichler, Abteilung Plastische Hand- und Wiederherstellungschirurgie, MHH: Kotransplantation von CD95L-tragenden Sertoli-Zellen in eine dermale Kunsthaut (INTEGRA) – erster Schritt zur Entwicklung eines immunpriveligierten Fremdhauttransplantates Dr. L. St-Onge, Firma Develogen, Göttingen: Stem cells and their future in the treatment of diabetes iPS Based Cell Therapies - From Bench to Bedside 03. - 04.12.2019 3. Internationales DZL-Symposium 08. - 10.05.2014 Das internationale Symposium „Lung Regeneration and Beyond – BREATH meets REBIRTH“ wird vom Deutschen Zentrum für Lungenforschung (DZL) - Standort Hannover BREATH zusammen mit dem Exzellenzcluster REBIRTH organisiert. Es findet vom 8.-10. Mai im Schloss Herrenhausen in Hannover statt. Schwerpunkte des Symposiums sind Regeneration, Transplantation, Stammzellforschung und Tissue Engineering, Imaging, ethische Fragestellungen der regenerativen Medizin sowie Patientenmeinungen zu regenerativer Wissenschaft. Mehr als 30 national und international führende Wissenschaftler der genannten Forschungsgebiete werden ihre neusten Ergebnisse vor bis zu 400 erwarteten Teilnehmern präsentieren, darunter angesehene Wissenschaftler, Nachwuchswissenschaftler und Studenten. Posterpräsentationen und gesellschaftliche Veranstaltungen bieten den Teilnehmern zahlreiche Möglichkeiten für Diskussionen und Networking. Weitere Informationen finden Sie hier . Den Flyer können Sie hier herunterladen.

Graduations PhD Infection Biology and DEWIN Graduations 2026 Graduation 30th January 2026 Abraham Ayanwale Research Topic: Defective interfering particles (DIPs) as novel effective antiviral tools against influenza and other emerging viral diseases Supervisor: Dr. Benjamin Nilsson-Payant, Institute of Experimental Virology, Twincore Academic Background: Infectious Diseases and One Health, Erasmus Nadine Brückner Research Topic: Herpesvirus Chromatin Programming during De Novo Infection Supervisor: Prof. Dr. Abel Viejo-Borbolla, Institute of Virology, MHH Academic Background: Virology, Biochemistry, Cell Biology, Immunology, University of Veterinary Medicine Hannover Tsung-Yu Chao Research Topic: Interferon induced responses during Herpes Simplex Virus skin infection Supervisor: Prof. Dr. Beate Sodeik, Institute of Virology, MHH Academic Background: Microbiology and Immunology, National Yang Ming University, Taiwan ROC Po-Chun Chen Research Topic:Effects of bile acids on Natural Killer cells in HDV patients Supervisor: Prof. Dr. Heiner Wedemeyer, Dpt. of Gastroenterology, Hepatology and Endocrinology, MHH Academic Background: Molecular Virology, National Taiwan University, Taiwan ROC Mariá Camila Ramírez Gutiérrez Research Topic: Immunosuppressive functions of the HCMV glycoprotein pUL11 Supervisor: Dr. Penelope Kay-Fedorov, Institute of Virology, MHH Academic Background: Biol. Sciences, Pontificia Universidad Javeriana, Bogotá, Colombia Dr. Lennart Riemann Research Topic: Immunological profiling of children with recurrent wheezing and its association with clinical outcome Supervisor: Prof. Dr. Reinhold Förster & Prof. Dr. Gesine Hansen, Institute of Immunology & Clinic of Paediatrics, Allergology and Neonatology, MHH Academic Background: Human Medicine, Ruprecht-Karls-Universität Heidelberg Andrea Spaić Research Topic: Pathogenicity of biofilms formed on medical implants and to develop innovative treatment strategies that target biofilm resistance mechanisms Supervisor: Prof. Dr. Meike Stiesch, Clinic for Dental Prosthetics, Hannover Medical School Academic Background: Microbiology, Novi Sad, Serbia Kai Wenk-Senst Research Topic: ocking of herpes simplex virus capsids to the nuclear pores and release of the viral genomes into the nucleoplasm for viral transcription and replication Supervisor: Prof. Dr. Beate Sodeik, Institute of Virology, MHH Academic Background: Biomedicine, Justus-Liebig Universität, Gießen Graduation 26th June 2026 Uriel Enrique Aquino Ruiz Research Topic: Modulation of immune cell function by flavivirus non-structural proteins Supervisor: Dr. Imke Steffen, Department of Biochemistry, University of Veterinary Medicine Hannover Academic Background: Immunology and Parasitology; Federal University of Uberlândia, Brazil Yiyang Cai Research Topic: Discovery of human genetic signatures affecting extracellular trap formation Supervisor: Dr. Volker Winstel, Pathogenesis of Bacterial Infections, Twincore & Institute of Medical Microbiology and Hospital Epidemiology, MHH and Justus-Liebig University Gießen Academic Background: Cell biology and microbiology, Imperial College London Abdulwahab Elsayed Research Topic: Novel mechanisms of immune dysregulation in seronegative spondyloarthropathies Supervisor: Prof. Dr. Torsten Witte, Clinic of Rheumatology and Immunology, MHH Academic Background: Genetic Engeneering Korea (South) Lisa Görtz Research Topic: Modulation of mitochondrial function in infections with Clostridioides difficile Supervisor: PD Dr. Matthias Lochner, Institute for Medical Microbiology and Hospital Epidemiology, MHH Academic Background: Molecular nutritional science, University of Hohenheim Elene Loliashvilli Research Topic: Epitranscriptomic regulation of VZV infection Supervisor: Prof. Dr. Daniel Depledge, Institute of Virology, MHH Academic Background: Molecular and Cellular Biology, LMU München Anne Rosier Research Topic: Characterization of the anti-inflammatory effects of soluble CD14 in mouse colitis models Supervisor: Prof. André Bleich, PhD, Institute for Laboratory Animal Science, MHH Academic Background: Veterinary Medicine, TiHo Josephine Schenk Research Topic: Modulation of cellular metabolism and intrinsic immune responses by Varicella Zoster Virus Supervisor: Prof. Dr. Abel Viejo-Borbolla, Institute of Virology, MHH Academic Background: Biomedicine, MHH Thu Hien Vu Research Topic: Laboratory evolution of antimicrobial resistance through horizontal gene transfer in bacterial communities Supervisor: Prof. Dr. Marco Galardini, Institute of Molecular Bacteriology Academic Background: Molecular Biology, University of Szeged, Hungary Ziqing Wang Research Topic: Understanding the impact of maternal factors and the developing microbiota on γδ T cell functionalities in the neonate Supervisor: Prof. Dr. Sarina Ravens, Institute of Immunology, MHH Academic Background: Immunology, molecular medicine, microbiology, Sun Yat-Sen University Graduations 2025 Graduation 31st January 2025 Bamu Fufor Damaris Research Topic: A microbial genotype-to-phenotype map for transcriptional regulation Supervisor: Prof. Dr. Marco Galardini, Institute of Molecular Bacterilogy, Twincore Academic Background: Master Infectious Disease and One Health, Erasmus Mundus Tours, Barcelona, EdinburghBelén Shruti Chopra Research Topic: Identification and characterisation of new possible risk genes for eczema herpeticum Supervisor: Prof. Dr. Thomas Werfel, Dept. Dermatology and Allergy, Division Immundermatology and Allergy Research, Hannover Medical School Academic Background: Biochemistry, Molecular Biology, University of Delhi South Campus, India Rita Haller Research Topic: Staphylococcal manipulation of human cell signaling systems Supervisor: Dr. Volker Winstel, Pathogenesis of Bacterial Infections, Twincore & Institute of Medical Microbiology and Hospital Epidemiology, MHH Academic Background: Molecular Microbiology, Leibniz University Hannover Ylenia Heinrich-Sanchez Research Topic: Specifying the ecology of trimethylamine-producing bacteria of human gut microbiota Supervisor: Dr. Marius Vital, Institute for Medical Microbiology and Hospital Epidemiology Academic Background: Translational Medical Research, Ruprecht-Karls-University Heidelberg Franziska Hüsers Research Topic: Elucidating the molecular mechanisms of MxB-mediated restriction of herpes simplex virus infections Supervisor: Prof. Dr. Beate Sodeik, Institute of Virology, MHH Academic Background: Biochemistry, MHH Karla Ximena León Lara Research Topic: Characterization of γδ T cells at the feto-maternal interface Supervisor: Prof. Dr. Sarina Ravens, Institute of Immunology, MHH Academic Background: Infectious Disease, National Autonomous University of Mexico Nina Plückebaum Research Topic: Characterization of novel modulatory strategies developed by human herpesviruses Supervisor: Prof. Dr. Abel Viejo-Borbolla, Institute of Virology, MHH Academic Background: Biomedicine, MHH Talia Samara Schneider Research Topic: Identifying new druggable targets in SARS-CoV-2-infected cells Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, MHH Academic Background: Animal Biology and Biomedical Sciences, TiHo Ilka Simons Research Topic: Maintainance and persistance of Human Adenovirus influenced by host restriction factors Supervisor: Prof. Dr. Sabrina Schreiner-Gruber, Institute of Virology, MHH Academic Background: Molekulare Biotechnologie, Technical University Munich Graduation 30th June 2025 Judit Burgaya Ventura Research Topic: Influence of the COVID-19 pandemic hygiene and distance rules on the transmission of multidrug-resistant pathogens in hospital settings Supervisor: Prof. Dr. Marco Galardini, Institute of Molecular Bacteriology, Twincore Academic Background: Applied Microbiology, Autonomus University of Barcelona, Spain Kim Thi Hoang Do Research Topic: The role of bronchus-associated lymphoid tissue (BALT) in lung immunity Supervisor: Prof. Dr. Reinhold Förster and Dr. Berislav Bosnjak, Institute of Immunology, MHH Academic Background: Medicine, Wonkwang University, College of Medicine, Korea (South) Lea Fritz Research Topic: Functional CRISPR/Cas9 manipulation of virus-specific T cells for the treatment of cytomegalovirus infections Supervisor: Prof. Dr. Reinhold Förster and Dr. Berislav Bosnjak, Institute of Immunology, MHH Academic Background: Biomedicine, Hanover Medical School Ahmed Hassan Research Topic: Characterization of peptide specific PLZF+ innate-like (PIL) T cells Supervisor: Prof. Dr. Reinhold Förster and Dr. Hristo Georgiev, Institute of Immunology, MHH Academic Background: Biotechnology and Molecular Biology, Vytauto Didziojo Universitetas, Lithuania Fenja Laue Research Topic: Pan-genotypic neutralizing antibodies as a therapeutic option against Hepatitis E Virus Supervisor: Dr. Patrick Behrendt, Research Group Translational Virology Academic Background: Infection biology and cell biology, TU Braunschweig Maureen Obara Research Topic: Spatial antibody treatment strategies of pulmonary SARS-COV-2 infection Supervisor: Prof. Dr. Ulrich Kalinke, Institute for Experimental Infection Research, Twincore Academic Background: Medical Microbiology; London School of Hygiene and Tropical Medicine Alaleh Rezalotfi Research Topic: Developing an in vitro test system to predict immunogenicity of biological compounds in humans Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, MHH and Prof. Dr. Armin Braun, Fraunhofer ITEM Academic Background: Medical Immunology, Hamadan University of Medical Sciences, Iran Marie-Sophie Schulze Research Topic: The herpesviral DNA polymerase-associated factor as a putative drug target Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, MHH Academic Background: Molecular Microbiology, Leibniz University Hannover Hannes Sommer Research Topic: Computational methods for the design of diagnostics and treatment oligonucleotides Supervisor: Prof. Dr. Marco Galardini, Institute of Molecular Bacteriology, Twincore Academic Background: Master of Science, Georg-August-University Göttingen Ju Eun Yoo Research Topic: Understanding the role of phosphatidylserine and its receptors in cross-species transmission of alphaviruses Supervisor: Prof. Dr. Gisa Gerold, Institute for Biochemistry, University of Veterinary Medicine Hannover Academic Background: Public Health in Environmental Health, Seoul National University, South Korea Graduations 2024 Graduation 19th January 2024 Belén Carriquí Madroñal Research Topic: Characterization of ADAM10 as a hepatitis C virus host factor Supervisor: Prof. Dr. Gisa Gerold, Institute of Biochemistry, TiHo Academic Background: Molecular Infection Biology, Julius-Maximilians-University, Würzburg Nicoletta Schwermann Research Topic: Staphylococcal modulation of apoptotic signaling pathways Supervisor: Dr. Volker Winstel, Pathogenese bakterieller Infektionen, TWINCORE & Institute of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Biomedicine, Hannover Medical School Rebecca Siemes Research Topic: Outwitting HCMV immunomodulatory functions – evaluation of NKG2D ligands to improve the immune response Supervisor: Prof. Dr. Martin Messerle, Institute of Virology, Hannover Medical School Academic Background: Biomedical Science, Maastricht University, Netherlands Katja Sophie Steppich Research Topic: The role of γδ T cells in hepatitis B virus infection Supervisor: Prof. Dr. Markus Cornberg, Dpt. of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology, Hannover Medical School Academic Background: Biomedicine, Hannover Medical School Tao Yang Research Topic: Development of γδ17 T Cells Across Life Supervisor: Prof. Dr. Sarina Ravens, Institute of Immunology, Hannover Medical School Academic Background: Biomedical Microbiology, Sun Yat-sen University, China Graduation 14th June 2024 Angela Aringo Research Topic: Comparative analysis of vaccine- and pathogen-induced antibody responses Supervisor: Prof. Dr. Ulrich Kalinke, Department of Experimental Infection Research, Twincore Academic Background: Erasmus Mundus in Vaccinology (Lyon, Barcelona, Antwerpen) Sarah Beyer Research Topic: Regulation of macrophages by OTUB2 in listeriosis and salmonellosis Supervisor: Prof. Dr. Dirk Schlüter, Institute for Medical Microbiology and Hospital Epidemiology, MHH Academic Background: Biomedicine, MHH Safaa Bouheraoua Research Topic: Investigation of the bi-directional interaction of Pseudomonas aeruginosa and the human host microenvironment in development of persistent infection in the lower respiratory tract of humans Supervisor: Prof. Dr. Susanne Häußler, Institute of Molecular Bacteriology, Twincore Academic Background: Infection, inflammation and cancer, University of Fribourg, Switzerland Sven Cleeves Research Topic: Influence of host-pathogen interactions in human lung tissue on the chronification of Pseudomonas aeruginosa infections Supervisor: Prof. Dr. Prof. Dr. Armin Braun, Fraunhofer Institute for Toxikoloy and Experimental Medicine - ITEM and Institute of Immunology, Hannover Medical School Academic Background: Molecular Medicine, Ulm University Sabrina Clever Research Topic: Recombinant MVA vaccines delivering SARS-2 antigens – search for correlates of protection against severe respiratory disease Supervisor: Prof. Dr. Asisa Volz, Institute for Virology, TiHo Academic Background: Animal Biology and Biomedical Sciences, TiHo Dilfuza Djamalova Research Topic: Pangenome wide prediction of gene function Supervisor: Prof. Dr. Marco Galardini, Institute of Molecular Bacteriology, Twincore Academic Background: Life Sciences, Skolkovo Institute, Moscow, Russia Rajendra Khanal Research Topic: Identification and functional evaluation of microRNAs during hepatitis delta virus infection Supervisor: Prof. Dr. Heiner Wedemeyer, Dpartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School Academic Background: Applied and Commercial Biotechnology, Inland Norway University of Applied Sciences Carolina Mastella Botelho Research Topic: Unravelling molecular mechanisms of resistance in the opportunistic pathogen Pseudomonas aeruginosa Supervisor: Prof. Dr. Susanne Häußler, Institute of Molecular Bacteriology, Twincore Academic Background: Infectious Disease and One Health Erasmus Mundus Joint Master Degree; Tours, Barcelona, Edinburgh Pia Peppermüller Research Topic: Deciphering the role of mesenteric lymph node stromal cells in the development of colonic inflammation Supervisor: Dr. Manuela Büttner, Institute for Laboratory Animal Science, MHH Academic Background: Molecular Microbiology, Leibniz University Hannover Rebecca Pospich Research Topic: Investigations on the T cell response to skin microbiota in atopic dermatitis Supervisor: Prof. Dr. Thomas Werfel, Clinic for Dermatology, Allergology and Venerology, Hannover Medical School Academic Background: Biochemistry, Infection Biology, Friedrich-Schiller-Universit at Jena, Germany Isita Sagar Research Topic: Function of OTUB1 in intestinal epithelial cells and macrophages in salmonellosis Supervisor: Prof. Dr. Dirk Schlüter, Institute for Medical Microbiology and Hospital Epidemiology, MHH Academic Background: Medical Biotechnology, Bharati Vidyapeeth University, Indien Melanie Urbanek-Quaing Research Topic: Impact of different chronic hepatitis viral infections on the epigenetic signature of immune cells Supervisor: Prof. Dr. Markus Cornberg, Dpt. of Gastroenterology, Hepatology and Endocrinology, MHH Academic Background: Biomedicine, MHH Graduations 2023 Graduation 20th January 2023 Kris Gerard Alvarez Research Topic: Role of Salmonella invasion mechanisms for disease development Supervisor: Prof. Dr. Guntram Graßl, Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Microbiology, University of the Philippines Los Baos Matthias Bruhn Research Topic: Molecular basis and early predictors of non-responsiveness to hepatitis B vaccination Supervisor: Prof. Dr. Ulrich Kalinke, Department of Experimental Infection Research, Twincore Academic Background: Genetics and Microbiology, Philipps-Universität Marburg, Germany Nicola Frericks Research Topic: Viral determinants of hepatitis C virus resistance to interferon and their relevance for broad resistance to HCV specific antivirals Supervisor: Dr. Julie Sheldon, Institute for Experimental Virology, Twincore Academic Background: Medical Biology, University Duisburg-Essen Alina Matthaei Research Topic: Interaction between hepatitis C virus and lipoproteins and its role for infection and viral persistence" Supervisor: Prof. Dr. Thomas Pietschmann, Institute for Experimental Virology, Twincore Academic Background: Virology, Microbiology, Immunology, Friedrich-Alexander University Erlangen-Nuremberg Samuel Osanyinlusi Research Topic: Immunomodulation by the Human Cytomegalovirus glycoprotein pUL11 Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, Hannover Medical School Academic Background: Advanced Virology, University of Lagos, Nigeria Timmy Richardo Research Topic: Dynamics of Herpes-Simplex Virus spread in skin and to the peripheral nervous system Supervisor: Prof. Dr. Beate Sodeik, Institute of Virology, Hannover Medical School Academic Background: Microbiology, Virology, Shimane Univ., Japan Katarzyna Szymanska-De Wijs Research Topic: Interference of mouse cytomegalovirus M25 proteins with the tumor suppressor protein p53 Supervisor: Prof. Dr. Martin Messerle, Institute of Virology, Hannover Medical School Academic Background: Biotechnology, Lodz University of Technology, Poland Eshraq Tantawy Research Topic: Unravelling a new virulence strategy by Staphylococcus aureus Supervisor: Dr. Volker Winstel, Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Infection Biology, University of Glasgow Graduation 30th June 2023 Azadeh Azadegan Research Topic: Exploring Kaposi Sarcoma-associated Herpesvirus Capsid Assembly and its Thymidine Kinase as Potential Antiviral Drug Targets Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, MHH Academic Background: Medical Microbiology, Tehran University of Medical Science, Iran Luise Krajewski Research Topic: Impact of HCMV infection on antigen presentation by primary human antigen presenting cells Supervisor: Prof. Dr. Ulrich Kalinke, Institute for Experimental Infection Research, Twincore Academic Background: Molecular Microbiology, LUH Hannover Felix Mulenge Research Topic: Exploitation of integrated multi-omics approaches for the analysis of brain responses to viral infection Supervisor: Prof. Dr. Ulrich Kalinke, Institute for Experimental Infection Research, Twincore Academic Background: Bioinformatics and Molecular Biology, Jomo Kenyatta University of Agriculture and Technology, Kenya Kodwo Appoh Odum Research Topic: Use of synthetic microbial communities to investigate the role of commensal bacteria in the development of murine norovirus-induced intestinal inflammation Supervisor: Prof. André Bleich, PhD, Institute for Laboratory Animal Science, MHH Academic Background: Microbiology, Uni Jena Sunayana Shyam Jandhyala Research Topic: The Role of the Autophagy Protein Optineurin in KSHV Infection Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, MHH Academic Background: Microbiology, Virology, Bioinformatics, Cell Biology; South Dakota State University, USA Tanvi Tikla Research Topic: Exploring the recruitment of phospholipase C gamma 1 by Kaposi’s sarcoma-associated herpesvirus K15 protein as a potential drug target Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, MHH Academic Background: Microbiology, University of Delhi, India Jiayi Wang Research Topic: Development of human neuronal models to investigate establishment of latency by varicella zoster virus Supervisor: Prof. Dr. Abel Viejo-Borbolla, Institute of Virology, MHH Academic Background: Pathogenic Biology, Qingdao University, China Melina Winkler Research Topic: Host factor usage of (+)-strand RNA viruses and their relevance for species tropism and their potential as targets for antiviral therapies Supervisor: Prof. Dr. Thomas Pietschmann, Institute for Experimental Virology, Twincore Academic Background: Biochemistry and Molecular Biology, Kiel Graduations 2022 Graduation 28th January 2022 Ryan Adriawan Research Topic: Monitoring of human γδ T cell repertoires in healthy individuals and during chronic viral infections using next generation sequencing technologies Supervisor: Prof. Dr. Reinhold Schmidt and Prof. Dr. Thorsten Witte, Department of Rheumatology and Clinical Immunology, Hannover Medical School Academic Background: Vaccinology, Barcelona, Antwerp, Lyon Malte Deseke Research Topic: In vivo study of the interaction of dendritic cells and γδ T cells in skin immunity, memory, and tolerance Supervisor: Prof. Dr. Immo Prinz, Institute of Immunology, Hannover Medical School and UKE Hamburg Academic Background: Biochemistry, University of Kiel, Germany Sarah Elsheik Research Topic: Targeting biofilm resistance mechanisms Supervisor: Prof. Dr. Susann Häußler, Institute of Molecular Bacteriology, Twincore Academic Background: Biotechnology, University of Leeds, UK Anika Freise Research Topic: Regulation of Kaposi Sarcoma Herpesvirus Latency through Interferon-Dependent Mechanisms Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, Hannover Medical School Academic Background: Cell Biology, University of Braunschweig, Germany Christopher Kesthely Research Topic: Targeting biofilm resistance mechanisms Supervisor: Prof. Dr. Susann Häußler, Institute of Molecular Bacteriology, Twincore Academic Background: Microbiology, University of New Brunswick, Canada Rebecca Möller Research Topic: Characterization of hepatitis C virus and arenaviruses co-infection Supervisor: Prof. Dr. Gisa Gerold, Institute for Experimental Virology, Twincore Academic Background: Immunology, Stiftung Tierärztliche Hochschule Hannover, Germany Gwendolyn Patzer Research Topic: Targeted TLO induction Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Infection Biology and Immunology, Philipps-Universität Marburg, Germany Marie-Madlen Pust Research Topic: Airway microbial metagenomics in health, bronchiectasis and COPD Supervisor: Prof. Dr. Burkhard Tümmler, Clinic for Paediatric Pneumology, Allergology and Neonatology, Hannover Medical School Academic Background: Microbiology, Infection Biology, University College Dublin, Ireland George Liam Ssebyatika Research Topic: Structural and biochemical characterization of viral and cellular glycoproteins with immunomodulatory functions Supervisor: Prof. Dr. Thomas Krey, Institute of Virology, Hannover Medical School and Biochemistry, University Lübeck Academic Background: Molecular Biology, Vrije Universiteit Brussels, Belgium Barbora Veselkova Research Topic: Structural and biochemical characterization of the envelope glycoproteins gp2,gp3 and gp4 of the Porcine reproductive and respiratory syndrome virus (PRRSV) Supervisor: Prof. Dr. Thomas Krey, Institute of Virology, Hannover Medical School and Biochemistry, University Lübeck Academic Background: Biology, LMU, Germany Graduation 8th July 2022 Cornelius Angela Research Topic: Binding of the N-terminal region of the large tegument protein HSV1-pUL36 to the host nucleoporin Nup358 C-terminus might initiate NPC docking Supervisor: Prof. Dr. Beate Sodeik, Institute of Virology, MHH Academic Background: Neurobiology, TU Braunschweig Jasper Götting Research Topic: DNA viral genomic diversity data for epidemiologic and diagnostic studies Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, MHH Academic Background: Biomedicine, MHH Carina Jürgens Research Topic: On the track: How a single viral protein may influence different steps of leukocyte migration and virus spread Supervisor: Prof. Dr. Abel Viejo-Borbolla, Institute of Virology, MHH Academic Background: Infection Biology, Uni Lübeck Laura Ospina Quintero Research Topic: Dynamics of human and mouse Cytomegalovirus-specific T cells and infected targets in lung explants Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, MHH Academic Background: Biomedical Sciences, University of Antioquia, Medellín Miguel Palacios Pedrero Research Topic: Age-related changes affecting the immune system contribute to suboptimal B and T cell responses in older adults receiving SARS-CoV-2 BNT162b2 mRNA vaccine Supervisor: Prof. Dr. Guus Rimmelzwaan and Prof. Dr. Ab Osterhaus, Research Center for Emerging Infections and Zoonoses, TiHo Academic Background: Molecular and Cellular Immunology, University of Granada, Spain Guorong Sun Research Topic: HSV-1 glycoprotein G promotes neurite outgrowth via exosome-associated factors to facilitate viral neuroinvasion Supervisor: Prof. Dr. Abel Viejo-Borbolla, Institute of Virology, MHH Academic Background: Preventive Veterinary Medicine, Harbin Veterinary Research; Institute (HVRI), Chinese Academy of Agricultural Sciences Nahuel Villarreal Research Topic: Characterization of the colitogenic candidate gene Alpk1 during infection Supervisor: Prof. André Bleich, PhD, Institute for Laboratory Animal Science, MHH Academic Background: Molecular Biotechnology, Univerity of Pisa Razieh Zargari Research Topic: The role of innate immune response in controlling Murine gammaherpesvirus 68 acute infection in vivo Supervisor: Dr. Stephan Halle, PhD and Prof. Dr. Melanie Brinkmann, Institute of Immunology, MHH Academic Background: Biology, Microbial Biotechnology, Ferdowsi University of Mashhad, Iran Graduations 2021 Graduation 29th January 2021 Elmira Aliabadi Research Topic: Role of HBV-specific immune responses for ‘HBV cure’ Supervisor: Prof. Dr. Markus Cornberg, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School Academic Background: Molecular Medicine, Georg-August Universität Göttingen, Germany Antonia Gunesch Research Topic: Antiviral mechanism of action and structure-function relationship of cationic amphiphilic drugs Supervisor: Prof. Dr. Thomas von Hahn, Institute for Molecular Biology, Hannover Medical School Academic Background: Microbiology and Genetics, RWTH Aachen, Germany Eleonora Naimo Research Topic: Identifying Key Components of the Virus-Cell Interaction using a Chemical Biology Approach Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, Hannover Medical School Academic Background: Molecular and cellular biology, University of Siena, Italy Georgia Papadogianni Research Topic: Characterization and functional analysis of invariant natural killer (iNKT) cells from wild type and mutant mice Supervisor: Prof. Dr. Günter Bernhardt, Institute of Immunology, Hannover Medical School Academic Background: Molecular Biology and Biomedicine, University of Crete, Greece Manutea Serrero Research Topic: Cytosolic host factors of immune cells interacting with HSV1 capsids Supervisor: Prof. Dr. Beate Sodeik, Instute of Virology, Hannover Medical School Academic Background: Immunology and Infectious Diseases, Toulouse, France Graduation 9th July 2021 Christoph Binz Research Topic: Investigating the specificity of γδ TCR Supervisor: Prof. Dr. Immo Prinz, Institute of Immunology, Hannover Medical School Academic Background: Biomedicine, Hannover Medical School, Germany Giacomo Castoro Research Topic: Structural and functional characterization of the Scavenger receptor BI Supervisor: Prof. Dr. Thomas Krey, Institute of Virology, Hannover Medical School Academic Background: Microbiology, Biotechnology, University of Messina, Italy Jared Kirui Research Topic: The role of TIM-1 and TSPAN9 in alphavirus host cell entry Supervisor: Prof. Dr. Gisa Gerold, Institute for Experimental Virology, Twincore Academic Background: Biotechnology, Wageningen, The Netherlands Christian Lanfermann Research Topic: Functional characterization of Chlamydia trachomatis 166 homologous effector proteins of C. psittaci, C. muridarum and other chlamydia species Supervisor: Prof. Dr. Andreas Klos, Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Microbiology, University of Würzburg, Germany Graduations 2020 Graduation 17th January 2020 Peter Naniima Research Topic: Molecular characterization of the capsid vertex specific component of herpesviruses Supervisor: Prof. Dr. Thomas Krey, Institute of Virology, Hannover Medical School Academic Background: Molecular Biology, Brussels, Belgium Ginka Nikolova Research Topic: Role of memory T cells in adaptive immune responses Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Molecular Immunology, Sofia University, Bulgaria David Andres Nivia Torres Research Topic: Developing Inhibitors of the Kaposi Sarcoma-associated Herpesvirus LANA protein Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, Hannover Medical School Academic Background: Microbiology, University of Oldenburg, Germany Dorcas Otoo Research Topic: Characterization of functional domains in the large tegument protein pUL36 of Herpes-Simplex Virus Type 1 Supervisor: Beate Sodeik, Institute of Virology, Hannover Medical School Academic Background: Microbiology, University of Basel, Switzerland Likai Tan Research Topic: Are tissue-resident γδ T cells local rheostats of inflammation? Supervisor: Prof. Dr. Immo Prinz, Institute of Immunology, Hannover Medical School Academic Background: Preventive Veterinary Medicine, South China Agricultural University, China Graduation 26th June 2020 Guilhermina Carriche Research Topic: Identification and functional characterization of metabolites with T cell modulatory capacity derived from the intestinal commensal microbiota Supervisor: Prof. Dr. Tim Sparwasser, Institute for Infection Immunology, Twincore Academic Background: Life Sciences, University of Porto, Portugal Alibek Galeev Research Topic: Role of glycoproteins in gastrointestinal infections Supervisor: Prof. Dr. Guntram Graßl, Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Food Safety / Microbiology, University of Helsinki, Finland Martin Kohn Research Topic: The immunoregulatory role of the C3a/C3R axis in experimental chlamydial lung Infection’ Supervisor: Prof. Dr. Andreas Klos, Institute for Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Science, University of Leipzig, Germany Shuting Li Research Topic: Targeting the cellular fatty acid metabolism in intestinal infection and inflammation Supervisor: Prof. Dr. Matthias Lochner, Institute for Infection Immunology, Twincore Academic Background: Clinical Laboratory Diagnostics, Sun Yat-sen University, China Joana Martins Research Topic: How γδ T cells regulate immune responses and immune tolerance Supervisor: Prof. Dr. Immo Prinz, Institute of Immunology, Hannover Medical School Academic Background: Biochemistry, Lisbon University, Portugal Ana Nascimento Research Topic: The role of ubiquitin in nuclear targeting of HSV1 capsids Supervisor: Prof. Dr. Beate Sodeik, Instute of Virology, Hannover Medical School Academic Background: Cell and Molecular Biology, University of Porto, Portugal Svenja Sake Research Topic: Determinants of respiratory syncytial virus (RSV) receptor usage and species tropism Supervisor: Prof. Dr. Thomas Pietschmann, Institute for Experimental Virology, Twincore Academic Background: Veterinary Medicine, TiHo, Hannover, Germany Samriti Sharma Research Topic: Susceptibility of toll like receptor-11 deficient mice to Salmonella infections Supervisor: Prof. Dr. Guntram Graßl, Department of Medical Microbiology, Hannover Medical School Academic Background: Biotechnoloy, Univ. College Dublin, Ireland Graduations 2019 Graduation 18th January 2019 Sergej Franz Research Topic: Impact of Type I Interferons on Maintaining HIV-1 Latency Supervisor: Prof. Dr. Christine Goffinet, Department of Experimental Virology, Twincore Academic Background: Technical Genetics, TU Darmstadt, Germany Ivana Kutle Research Topic: Role of tegument proteins on acute and chronic mouse cytomegalovirus infection Supervisor: Prof. Dr. Martin Messerle, Institute of Virology, Hannover Medical School Academic Background: Molecular Biology, Zagreb University, Croatia Shahab Nahrevanian Research Topic: Strategies for identification and characterization of antivirals against cytomegalovirus Supervisor: Prof. Dr. Martin Messerle, Institute of Virology, Hannover Medical School Academic Background: Molecular Biology, Umea University, Sweden Sara Nogueira Research Topic: Homing via afferent lymphatics Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Veterinary Medicine, University of Porto, Portugal Katarzyna Pienkowska Research Topic: Co-evolution of the intestinal and airways microbial metagenomes in people with cystic fibrosis Supervisor: Prof. Dr. Burkhard Tümmler, Clinic for Paediatric Pneumology and Neonatology, Hannover Medical School Academic Background: Biotechnology, Warsaw University, Poland Brenda Raud Research Topic: Metabolic influences that regulate CD4 T cell function Supervisor: Prof. Dr. Tim Sparwasser, Institute for Infection Immunology, Twincore Academic Background: Biotechnology, Universidad Nacional del Litoral, Argentina Thomas Schirdewahn Research Topic: The role of NK cells and T cells in the pathogenesis of hepatitis delta Supervisor: Prof. Dr. Hans-Heinrich Wedemeyer, Dept. of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School Academic Background: Microbiology, Carl von Ossietzky Uni Oldenburg, Germany Graduation 28th June 2019 Amare Gebrehiwot Aregay Research Topic: Effect of anti-viral therapy and liver transplantation on T and NK cells during chronic hepatitis C Supervisor: Prof. Dr. Hans-Heinrich Wedemeyer, Dept. of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School Academic Background: Medical Biotechnology, Wageningen, The Netherlands Akshay Dhingra Research Topic: Next generation sequencing of human cytomegalovirus (HCMV) populations directly from clinical specimens of immunocompromised hosts Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, Hannover Medical School Academic Background: Biotechnology, Pondi-cherry University, India Nadine Eckert Research Topic: Role of CCRL1 in controlling intestinal immunity Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Molecular Medicine, Georg-August-University Göttingen Luca Ghita Research Topic: Virus control and pathology in herpes simplex encephalitis Supervisor: Prof. Dr. Ulrich Kalinke, Department of Experimental Infection Research, Twincore Academic Background: Medical Microbiology, Molecular Medicine, University of Milan, Italy Ana Hickford-Martinez Research Topic: Cell-type specific cytosolic host factors interacting with HSV1 capsids Supervisor: Prof. Dr. Beate Sodeik, Institute of Virology, Hannover Medical School Academic Background: Biomedicine, University of Lancaster, UK Chai Fen Soon Research Topic: Role of hepatitis E virus (HEV) infection in the induction of autoimmune hepatitis (AIH) Supervisor: Prof. Dr. Hans-Heinrich Wedemeyer, Dept. of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School Academic Background: Cancer Biology, Immunology, Osaka University, Japan Julio Cesar Villalvazo Guerrero Research Topic: Molecular characterization of small chemical compounds blocking HSV1 replication Supervisor: Prof. Dr. Beate Sodeik, Institute of Virology, Hannover Medical School Academic Background: Molecular and Physiological Biology, Katholieke Universiteit Leuven, Belgium Anneke Wilharm Research Topic: Sentinels of the Oral Epithelium - Elucidating the Development and Function of Oral γδ T Cells and their Interplay with Langerhans Cells Supervisor: Prof. Dr. Immo Prinz, Institute of Immunology, Hannover Medical School Academic Background: Biomedicine, Hannover Medical School, Germany Francisco Jose Zapatero Belinchon Research Topic: Definition of a minimal set of cell surface molecules required for filovirus cell entry Supervisor: PD Dr. Thomas von Hahn, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School Academic Background: Infection Biology, University of Glasgow, UK Graduations 2018 Graduation 26th January 2018 Bizunesh Abere Alamirew Research Topic: The role of cellular tyrosine kinases in Kaposi sarcoma herpesvirus (KSHV) –mediated pathological angiogenesis Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, Hannover Medical School Academic Background: Molecular Genetics, Mahi-dol University, Thailand Sandra Koch Research Topic: A novel role for a viral interferon regulatory factor during the establishment of latency Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, Hannover Medical School Academic Background: Biology, TU Braunschweig, Germany Girmay Desalegn Tarekegn Research Topic: Context-dependent modulation of monocyte differentiation and function in the gut Supervisor: Prof. Dr. Oliver Pabst, Institute of Immunology, Hannover Medical School Academic Background: Clinical Laboratory Science, Addis Ababa University, Ethiopia Graduation 15th June 2018 Sudeep Bhushal Research Topic: Dynamics of IFN-virus interplay Supervisor: Dr. Hansjörg Hauser, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Immunology, Radboud University Nijmegen, The Netherlands Rui Costa Research Topic: Impact of host variation in the SCARB1 gene on the development and maintenance of chronic hepatitis C Supervisor: PD Dr. Sandra Ciesek, Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School Academic Background: Biochemistry, University of Coimbra, Portugal Sebastian Joecks Research Topic: Pathways of Intracellular Lipoprotein Recruitment During Hepatitis C Virus Assembly and Maturation Supervisor: Prof. Dr. Thomas Pietschmann, Department of Experimental Virology, Twincore Academic Background: Biochemistry, University of Bielefeld, Germany Jenny Poetzsch Research Topic: Homing of immune cells via afferent lymphatics Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Molecular Medicine, University of Jena, Germany Naira Samarina Research Topic: A genetic approach to identifying host factors involved in herpesviral reactivation in humans Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, Hannover Medical School Academic Background: Molecular and Cellular Biotechnology, Southern Federal University, Rostow-am-Don, Russia Shuyong Zhu Research Topic: Modulation of the immune and nervous system mediated by human alphaherpesviruses Supervisor: Prof. Dr. Abel Viejo-Borbolla, Institute of Virology, Hannover Medical School Academic Background: Botany, Lanzhou University, China Graduations 2017 Graduation 13th January 2017 Yvonne Bischoff Research Topic: Immune mechanisms controlling latent MCMV infections in mice Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Biomedicine, Hannover Medical School, Germany Inga Brüsch Research Topic: Cdcs1-determined colitis susceptibility: immunological and microbial factors Supervisor: Prof. Dr. André Bleich, Central Animal Laboratory, Hannover Medical School Academic Background: Veterinary Medicine, Giessen University, Germany Elias Hage Research Topic: A role for paradoxically activated MEK/ERK signalling pathways and persistent known and novel viruses in non-melanoma skin cancer of patients treated with BRAF inhibitors Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, Hannover Medical School Academic Background: Infection & Immunity, University of Leeds, UK Ciro Lino Research Topic: Effector functions and antigen-specificity of tissue-resident γδ T cells in the course of fungal infections Supervisor: Prof. Dr. Immo Prinz, Institute of Immunology, Hannover Medical School Academic Background: Immunology, University of Sao Paulo, Brazil Mario Schmidt Research Topic: Tubulin modifications and their cellular functions during infections Supervisor: Prof. Dr. Lothar Jänsch, Cellular Proteom Research, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biochemistry, Hannover Medical School, Germany Anika Schridde Research Topic: Functional plasticity of intestinal macrophages in steady state and infection Supervisor: Prof. Dr. Oliver Pabst, Institute of Immunology, Hannover Medical School Academic Background: Biomedicine, Hannover Medical School, Germany Sylvia Wagenknecht Research Topic: Immunological effects of the antimicrobial peptide RNAse7 Supervisor: Prof. Dr. Thomas Werfel, Clinic for Dermatology, Allergology and Venerology, Hannover Medical School Academic Background: Microbiology, Eberhard-Karls-University Tübingen, Germany Stephanie Walter Research Topic: Characterization of viral and host factors controlling trans-species transmission of hepaciviruses Supervisor: PD Dr. Eike Steinmann, Department of Experimental Virology, Twincore Academic Background: Molecular Biotechnology, University of Bielefeld, Germany Graduation 16th June 2017 Janina Brüning Research Topic: Proteomic analysis of lipoprotein-dependent changes in the Hepatitis C virus receptor complex Supervisor: Prof. Dr. Thomas Pietschmann/Dr. Gisa Gerold, Department of Experimental Virology, Twincore Academic Background: Biomedicine, Hannover Medical School, Germany Bettina Buchmann Research Topic: Identification of host cell requirements and antiviral targets hepatitis D virus infection Supervisor: PD Dr. Thomas von Hahn, Institute for Molecular Biology, Hannover Medical School Academic Background: Microbiology, University of Oldenburg, Germany Mathias Riehn Research Topic: T cell response and inflammation upon controlled antigen presentation in lung Supervisor: Dr. Dagmar Wirth, Model Systems for Infections, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Molecular Biology, FU Berlin, Germany Valery Volk Research Topic: A humanized mouse model of stem cell transplantation to evaluate B cell development and humoral responses against cytomegalovirus Supervisor: Prof. Dr. Renata Stripecke, Department of Hematology, Hannover Medical School Academic Background: Immunology, Belarusian State University, Belarus Graduation 10th November 2017 Marcela Françozo Research Topic: To investigate the anti-viral function of MyD88 dependent signalling in dendritic cell and macrophages during MCMV infection Supervisor: Prof. Dr. Tim Sparwasser, Institute for Infection Immunology, Twincore Academic Background: Cellular Immunology, University of Sao Paulo, Brazil Graduations 2016 Graduation 22 January 2016 Nkacheh Atenchong Research Topic: Tight junction components as cell entry factors for epitheliotropic viruses Supervisor: Dr. Thomas von Hahn, Institute for Molecular Biology, Hannover Medical School Academic Background: Microbiology, Oldenburg University, Germany Christoph Hirche Research Topic: Impact of type I interferon-induced hematopoietic stem cell proliferation on immune cell homeostasis and anti-viral immune cell responsiveness Supervisor: Prof. Dr. Ulrich Kalinke, Department of Experimental Infection Research, Twincore Institute Academic Background: Veterinary Science, University of Veterinary Medicine, Hannover, Germany Karan Kohli Research Topic: Spatio-temporal distribution of plasmacytoid DC in immunity and tolerance: A 2Photon microscopy study Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Biotechnology, Texas, USA Patricia Morán Losada Research Topic: The upper and lower airways microbiome of individuals with cystic fibrosis Supervisor: Prof. Dr. Burkhard Tümmler, Clinic for Paediatric Pneumology and Neonatology , Hannover Medical School Academic Background: Bioinformatics, Madrid, Spain Gülhas Solmaz Research Topic: To investigate the role of neonatal toll like receptor 7 in a VSV infection model Supervisor: Prof. Dr. Tim Sparwasser, Institute for Infection Immunology, Twincore Institute Academic Background: Microbiology, University of Ankara, Turkey Kim Tappe Research Topic: Interference of HIV-1 with lysosomal degration: Implication for pathogenesis and viral immunity Supervisor: Prof. Dr. Georg Behrens, Clinic for Immunology and Rheumatology, Hannover Medical School Academic Background: Biochemistry, Hannover Medical School, Germany Kai Yu Research Topic: Differentiation and function of regulatory macrophages (regMФ) Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Mucosal Immunology, China CDC, Beijing, China Guigen Zhang Research Topic: The changing composition of KSHV LANA containing nuclear speckles in different phases of the cell cycle Supervisor: Prof. Dr. Thomas Schulz, Institute of Virology, Hannover Medical School Academic Background: Biochemistry, Peking Union Medical College, China Kaiyi Zhang Research Topic: Spacial and temporal changes of the intestinal epithelial gene expression and its functional role for mucosal homeostasis Supervisor: Prof. Dr. Mathias Hornef, Department for Medical Microbiology, Hannover Medical School Academic Background: Biochemistry, Wageningen, The Netherlands Jasmin Zischke Research Topic: Viral immune modulation: properties and applications of Human Cytomegalovirus UL11 Supervisor: Prof. Dr. Thomas Schulz/ Dr. Penelope Kay-Fedorov, Department of Virology, Hannover Medical School Academic Background: Biomedicine, Hannover Medical School, Germany Graduation 17th June 2016 Hristo Georgiev Research Topic: Regulation of the expression of the T and NK cell inhibitory receptor TIGIT Supervisor: Dr. Günter Bernhardt, Institute of Immunology, Hannover Medical School Academic Background: Molecular Cell Biology, Sofia University, Bulgaria Peyman Ghorbani Research Topic: Role of CD103-expressing T cells and dendritic cells for immune regulation during bacterial infection Supervisor: Prof. Dr. Tim Sparwasser, Institute for Infection Immunology, Twincore Academic Background: Immunology, University of Toronto, Canada Angelika Hinz Research Topic: Cytosolic host restriction factors recognizing incoming HSV1 Supervisor: Prof. Dr. Beate Sodeik, Institute of Virology, Hannover Medical School Academic Background: Biology, Leipzig University, Germany Carolin Maria Hoppe Research Topic: Importance of UDP-glucose Biosynthesis for the Parasite Leishmania major Supervisor: Prof. Dr. Françoise Routier, Department of Cellular Chemistry, Hannover Medical School Academic Background: Biochemistry, Hannover Medical School, Germany Mohammed Nooruzzaman Research Topic: Functional implications of host genetic factors affecting control of hepatitis C virus infection Supervisor: Prof. Dr. Ulrich Kalinke, Institute for Experimental Infection Research, Twincore Institute Academic Background: Veterinary Pathology, immunopathology, Bangladesh Agricultural University Jörn Pezoldt Research Topic: Identification of microenvironmental factors and molecular signals modulating the tolerogenic properties of stromal cells in gut-draining lymph nodes Supervisor: Prof. Dr. Jochen Hühn, Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Molecular Biotechnology, Heidelberg University, Germany Annika Reinhardt Research Topic: Antigen-specific activation, effector functions, and spatio-temporal distribution of γδ T cells in the course of microbial infections Supervisor: Prof. Dr. Immo Prinz, Institute of Immunology, Hannover Medical School Academic Background: Biomedicine, Hannover Medical School, Germany Kathrin Werth Research Topic: Role of neutrophils and eosinophils in adaptive immune responses Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Veterinary Medicine, University of Veterinary Medicine Hannover, Foundation Graduations 2015 Graduation 23rd January 2015 Dagmara Bialy Research Topic: The dynamics of intracellular transport of Herpes Simplex Virus during neuronal infections Supervisor: Prof. Dr. Beate Sodeik, Institute of Virology, Hannover Medical School Academic Background: Biotechnology, University of Gdánsk, Poland Juliane Mohr Research Topic: The effect of protease-mediated peptide and amino acid catabolism in Campylobacter jejuni on its proliferation, intracellular survival and persistence in a murine colonization model Supervisor: Prof. Dr. Dirk Hofreuter, Department of Medical Microbiology, Hannover Medical School Academic Background: Biology, University of Halle, Germany Ulrike Richter Research Topic: The dynamics of interaction between herpes- and retroviral genomes and host chromatin Supervisor: Prof. Dr. Thomas Schulz, Department of Virology, Hannover Medical School Academic Background: Biology, Georg-August University, Göttingen, Germany Monika Schniederjans Research Topic: Identification of novel antibiotic resistance determinants in Pseudomonas aeruginosa Supervisor: Prof. Dr. Susanne Häußler, Chronic Pseudomonas Infections, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Animal Biology & Bio-medical Sciences, University of Veterinary Medicine, Hannover, Germany Andrzej Taranta Research Topic: Interaction of hepatitis B virus – hepatitis Delta Virus co-infection in a humanized mouse model Supervisor: Prof. Dr. Michael Manns/Dr. Karsten Wursthorn, Dept. of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School Academic Background: Biochemistry, University of Gdansk, Poland Nguyen Dinh Van Research Topic: Anti-viral potential of inflammatory non-interferon mediators Supervisor: Dr. Thomas von Hahn, Dept. of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School Academic Background: Animal Biotechnology Virology, Seoul, Korea Julia Visic (née Bortfeld) Research Topic: The role of IRAK-1 in inflammatory responses of the lung Supervisor: Prof. Dr. Gesine Hansen, Department of Pediatric Pneumology and Neonatology, Hannover Medical School Academic Background: Diploma in Biology, Leibniz University, Hannover Graduation 10th July 2015 Silvia Gramolelli Research Topic: The PLCγ/calcineurin/NFAT pathway as a novel therapeutic target for Kaposi Sarcoma Herpesvirus-induced aberrant angiogenesis Supervisor: Prof. Dr. Thomas Schulz, Department of Virology, Hannover Medical School Academic Background: Biology, Biomedical Research, Rome, Italy Lyudmila Ivanova Research Topic: The assembly of Herpes Simplex Virus – the inner tegument protein pUL36 Supervisor: Prof. Dr. Beate Sodeik, Institute of Virology, Hannover Medical School Academic Background: Biochemistry, Sofia University, Bulgaria Dino Kocijancic Research Topic: Therapy of solid tumors using recombinant probiotic E. coli Supervisor: Dr. Siegfried Weiß, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Molecular Biomedicine, Copenhagen, Denmark Jennifer Oduro Research Topic: Congenital CMV Infection in Development and Maintenance of the T-Cell Compartment Supervisor: Dr. Luka Cicin-Sain, Immune Aging and Chronic Infections, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Molecular Medicine, Charité, Berlin, Germany Solomon Owusu Sekyere Research Topic: Relevance of serological and immune marker in HBV/HCV-coinfected patients Supervisor: Prof. Dr. Hans Heinrich Wedemeyer, Dept. of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School Academic Background: Microbiology/ Immunology, Uppsala, Sweden Paula Perin Research Topic: Characterization of Hepatitis C Virus-specific antiviral compounds and viral resistance mechanisms Supervisor: Prof. Dr. Thomas Pietschmann, Department of Experimental Virology, Twincore Institute Academic Background: Molecular Biology, University of Göttingen, Germany Nantaporn Ruangkiattikul Research Topic: Molecular interactions of Mycobacterium avium subsp. paratuberculosis with host cells Supervisor: Prof. Dr. Peter Valentin-Weigand, Institute for Microbiology, University of Veterinary Medicine, Hannover Academic Background: Environmental Toxicology, Chulabhorn Grad. Institute, Thailand Inga Sandrock Research Topic: Contribution of Th17-type cytokine producing γδ T cells to the control of microbial infections Supervisor: Prof. Dr. Immo Prinz, Institute of Immunology, Hannover Medical School Academic Background: Molecular Medicine, University of Freiburg, Germany Danim Shin Research Topic: Interplay of TLR and RIG-I mediated anti-viral signalling in virus infection Supervisor: Prof. Dr. Hansjörg Hauser, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Molecular Biotechnology, TU Braunschweig, Germany Nadine Thiel Research Topic: Characterization of mouse cytomegalovirus genes affecting surface molecules on antigen presenting cells Supervisor: Prof. Dr. Martin Messerle, Institute of Virology, Hannover Medical School Academic Background: Biochemistry, Hannover Medical School, Germany Graduations 2014 Graduation 24th January 2014 Marijana Basic Research Topic: Dynamic interaction between bacteria and the intestinal barrier Supervisor: Prof. Dr. André Bleich, Central Animal Laboratory, Hannover Medical School Academic Background: Biology, University of Zagreb, Croatia Anusara Daenthanasanmak Research Topic: Genetically programmed dendritic cells expressing the non-structural Hepatitis C virus protein cluster: in vitro and in vivo analyses of multiantigenic and antigen-specific T cells Supervisor: Prof. Dr. Renata Stripecke, Department of Hematology, Hemostasiology and Oncology, Hannover Medical School Academic Background: MSc Molecular Life Sciences, University of Stockholm Marius Döring Research Topic: Functional analysis of rare allotypes of human Toll-like receptor 9 Supervisor: Prof. Dr. Ulrich Kalinke, Department of Experimental Infection Research, Twincore Academic Background: MSc Biotechnology, RWTH Aachen Henrike Fleige Research Topic: Imaging of Antigen-presentation and DC-T interaction in Bronchus associated lymphoid tissue, BALT Supervisor: Prof. Dr. Reinhold Förster, Institute for Immunology, Hannover Medical School Academic Background: MSc Biomedicine, Hannover Medical School Kerstin Gnirss Research Topic: Comparative analysis of HIV and Ebolavirus counteraction of tetherin, a novel antiviral host cell protein Supervisor: Prof. Dr. Stefan Pöhlmann, Institute of Virology, Hannover Medical School Academic Background: Biomedicine, Hannover Medical School, Germany Kirstin Jurrat Research Topic: Signal network analyses of the Met pathway activated by the invasin Internalin B from Listeria monocytogenes Supervisor: Dr. Lothar Jänsch, Department of Cell Biology, Helmholtz Centre for Infection Research Academic Background: Diploma in Biochemistry, Ernst-Moritz-Arndt-University Greifswald Felix Stahl Research Topic: Spatio-temporal distribution of mCMV following oral infection and inti-viral defence strategies in new born mice Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Medicine, University of Hamburg, Germany Graduation 11th July 2014 Patrick Bartholomäus Research Topic: Analysis of the superagonistic anti-CD28 mediated T cell stimulation Supervisor: Prof. Dr. Ulrich Kalinke, Department of Experimental Infection Research, Twincore Institute Academic Background: Biology, Molecular Virology, Johannes-Gutenberg University, Mainz, Germany Friederike Behler-Janbeck Research Topic: Dynamics of the lung host defense against S. pneumoniae infection in mice: role of the macrophage-inducible C-type lectin Mincle Supervisor: Prof. Dr. Ulrich Maus, Department of Pulmonary Medicine, Hannover Medical School Academic Background: Molecular Life Science, University of Lübeck, Germany Fiordiligie Casilag Research Topic: Immune Evasion in the initial phase of Pseudomonas aeruginosa biofilm development Supervisor: Prof. Dr. Susanne Häußler, Department for Pathophysiology of Bacterial Biofilms, Twincore Academic Background: Biology, Mokpo National University, South Korea Michael Frahm Research Topic: LPS attenuated Salmonella typhimurium for tumor therapy Supervisor: Dr. Siegfried Weiß, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Veterinary Medicine, Szent István University, Budapest, Hungary Rebecca Geyer Research Topic: Signaling processes inducing cytoskeletal rearrangements upon Yersinia host cell interaction Supervisor: Prof. Dr. Petra Dersch, Department of Molecular Infection Biology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, University of Mainz, Germany Julia Heinrich Research Topic: Redundant and non-redundant pathways of virus sensing Supervisor: Prof. Dr. Ulrich Kalinke, Department of Experimental Infection Research, Twincore Academic Background: Human Biology, Ernst-Moritz-Arndt University, Greifswald, Germany Elham Kashani Research Topic: Analysis of TCR-repertoire dynamics of FoxP3+ regulatory T cells and γδ T cells in the course of microbial infections Supervisor: Dr. Immo Prinz, Institute of Immunology, Hannover Medical School Academic Background: Biology, Ulm University, Germany Jennifer Kleine-Albers Research Topic: Longitudinal analysis of maintenance mechanisms of cytomegalovirus genomes and of the immunological control during the chronic infection Supervisor: Prof. Dr. Martin Messerle, Department of Virology, Hannover Medical School Academic Background: Biomedical Sciences, Pharmacology, University of Aberdeen, UK Thalea Koithan Research Topic: Identification and characterization of new host factors required for the cell entry of herpes simplex virus type 1 into neurons Supervisor: Prof. Dr. Beate Sodeik, Virology, Hannover Medical School Academic Background: Biotechnology, Technical University Braunschweig, Germany Johannes Schwerk Research Topic: Identification of Interferon target cells and their time-resolved induction by viral infection Supervisor: Prof. Dr. Hansjörg Hauser, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, TU Braunschweig, Germany Milas Ugur Research Topic: Modulation of immune cell egress during infection Supervisor: Prof. Dr. Oliver Pabst, Institute of Immunology, Hannover Medical School Academic Background: Biotechnology, Yeditepe University, Istanbul, Turkey Zuobai Wang Research Topic: Mechanisms of dendritic cell mediated recognition and immune regulation in intestinal infections with Citrobacter rodentium Supervisor: Prof. Dr. Tim Sparwasser, Institute for Infection Immunology, Twincore Academic Background: Biology, Uppsala University, Sweden Graduations 2013 Graduation 25th Jan 2013 Anna Buch Research Topic: The secondary envelopment of HSV 1 in epithelial cells and neurons Supervisor: Prof. Dr. Beate Sodeik, Department of Virology, Hannover Medical School Academic Background: Biology, Leibniz University Hannover, Germany Elena Grabski Reserarch Topic: Virus-Induced type I interferon responses by human antigen presenting cells Supervisor: Prof. Dr. Ulrich Kalinke, Experimental Infection Research, Twincore, Hannover Academic Background: Biochemistry, Goethe University Frankfurt, Germany Sarah Hinkelmann Research Topic: Egress of morbilliviruses from host cells Supervisor: Prof. Dr. Georg Herrler & Prof. Dr. Ludwig Haas, Department of Virology, University of Veterinary Medicine Hannover, Foundation Academic Background: MSc Biomedicine, Hannover Medical School Yi-Ju Huang Research Topic: Functional properties, plasticity and de novo induction of Foxp3+ regulatory T cells within the gut mucosa and gut-associated lymphoid tissues Supervisor: Prof. Dr. Jochen Hühn, Department of Experimental Immunology, Helmholtz Centre for Infection Research Academic Background: MSc Virology, National Taiwan University Lucas Kemper Research Topic: Crosstalk of T cell receptor signaling and IFN receptor signaling Supervisor: Dr. Hansjörg Hauser, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research Academic Background: Diploma in Biology, Carl von Ossietzky University, Oldenburg Uliana Komor Research Topic: An animal model for biofilm formation of Pseudomonas aeruginosa Supervisor: Dr. Siegfried Weiß, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research Academic Background: Diploma in Biology, Novosibirsk State University Cornelia Lindner Research Topic: The function of follicular nodules in the gut and peritoneal cavity for the generation of intestinal Immunoglobulin A Supervisor: Prof. Dr. Oliver Pabst, Institute for Immunology, Hannover Medical School Academic Background: MSc Biomedicine, Hannover Medical School Graduation 28th June 2013 Andrea Bischof Research Topic: Role of basophils in immunological memory responses to pneumococcal protein antigens and S. pneumoniae infections in mice Supervisor: PD Dr. Ulrich Maus, Department of Experimental Pneumology, Hannover Medical School Academic Background: MSc Molecular Life Science, Friedrich-Alexander University Erlangen-Nuremberg Simon Danisch Research Topic: Function of the CD155 ligands TIGIT/WUCAM, CD96 and CD226 in the induction of humoral immunity Supervisor: Dr. Günter Bernhardt, Institute for Immunology, Hannover Medical School Academic Background: MSc Biomedicine, Hannover Medical School Baishakhi Datta Research Topic: Comparison of Chlamydia trachomatis serovars D and L2 with serovars A and Ba on human dendritic cells and peripheral blood monocytes Supervisor: PD Dr. Annette Wagner, Department of Nephrology, Hannover MedicalSchool Academic Background: MSc Molecular Biology, University of Sussex Deepika Devadas Research Topic: The dynamics and modes of Herpes Simplex Virus entry into different cell types Supervisor: Prof. Dr. Beate Sodeik, Institute for Virology, Hannover Medical School Academic Background: MSc Molecular Medical Microbiology, University of Nottingham Adarsh Dharan Research Topic: Hepatitis C virus nonstructural protein domains required for the formation and correct subcellular targeting of the viral replication complex Supervisor: Dr. Benno Wölk, Institute for Virology, Hannover Medical School Academic Background: MSc Genetic Manipulation and Molecular Cell Biology, University of Sussex Harro Frauendorf Research Topic: Impact of in vivo reduced regulatory T cells on priming of respiratory virus-specific T cell responses, immunopathology and pathogen clearance Supervisor: Dr. Dunja Bruder, Department of Immunregulation, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, Technical University Braunschweig, Germany Kathrin Hüging Research Topic: Identification of host factors limiting HCV replication and assembly in non-human and non-liver cells Supervisor: Prof. Dr. Thomas Pietschmann, Department of Experimental Virology, Twincore Academic Background: MSc Biomedicine, Hannover Medical School Natascha Kruse Research Topic: Establishment of a mouse model for liver specific HCV expression and replication Supervisor: Dr. Dagmar Wirth, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research Academic Background: Diploma in Biochemistry, Leibniz University, Hannover Wiebke Opitz Research Topic: Host factors implicated in β1-integrin initiated transcytosis of Yersinia pseudotuberculosis Supervisor: Prof. Dr. Petra Dersch, Department of Molecular Infection Biology, Helmholtz Centre for Infection Research Academic Background: MSc Biology, TU Braunschweig Graduation 8th November 2013 Wiebke Ginter Research Topic: Role of human DC-SIGN in anti-fungal immunity Supervisor: Prof. Dr. Tim Sparwasser, Institute for Infection Immunology, Twincore Academic Background: Diploma in Biology, Friedrich-Schiller-University Jena Graduations 2012 Graduation 20th January 2012 Asolina Braun Research Topic: Role of lymph node stromal cells for tissue maintenance under homeostatic and inflammatory conditions Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic background: Biology, Leibniz University Hannover, Germany Jan Haas Research Topic: Elucidation of the contribution of T cells to γδ Th17-type immune reactions in steady state and in the course of infections Supervisor: Dr. Immo Prinz, Institute of Immunology, Hannover Medical School Academic Background: Technical Biochemistry, University of Stuttgart, Germany Semrah Kati Research Topic: The role of the epigenetic modifications during KSHV latent persistence Supervisor: Prof. Dr. Thomas Schulz, Department of Virology, Hannover Medical School Academic Background: Biochemistry, Leibniz University, Hannover, Germany Georgios-Leandros Moschovakis Research Topic: Conditional CCR7-deficient and CCR7-proficient mice to study Tolerance and Immunity Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Medicine, Medical University Innsbruck, Austria Christina Ziegler Research Topic: Host-microbe interplay in persistant Staphylococcus aureus infection Supervisor: Dr. Eva Medine, Department of Infection Immunology, Helmholtz Centre for Infection Research Academic Background: Molecular Biology, University of Bergen, Norway, Germany Graduation 13th July 2012 Lucie Bartonícková Research Topic: Characterization of the type IV secretion system and secreted effectors in host interaction by Helicobacter hepaticus Supervisor: Prof. Dr. Christine Josenhans, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic background: Microbiology and Medicine, Charles University Prague, Czech Republic Christina Brumshagen Research Topic: Role of mononuclear phagocytes in lung protective immunity against S. pneumoniae infections Supervisor: PD Dr. Ulrich Maus, Department of Pulmonary Medicine, Hannover Medical School Academic background: Biology, Leibniz University Hannover, Germany Marcin Cebula Research Topic: T cell response to hepatropic viruses in transgenic mice Supervisor: Dr. Dagmar Wirth, Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biotechnology, Jagiellonian University Krakow, Poland Johanna Eberhard Research Topic: Hepatitis C Virus - Human Immunodeficiency Virus Coinfection: Immune Mechanisms, Viral Interactions and Pathogenesis Supervisors: Prof. Dr. Reinhold Schmidt and Dr. Dirk Meyer- Olson, Clinical Immunology, Hannover Medical School Academic Background: Biology, Leibniz University Hannover, Germany Ildar Gabaev Research Topic: Characterization of the immunomodulatory polymorphic RL11 glycoprotein of human cytomegalovirus Supervisor: Prof. Dr. Martin Messerle, Department of Virology, Hannover Medical School Academic Background: Biology, Irkutsk State University, Russia Stephan Halle Research Topic: In vivo visualisation of the immune response and its modulation during herpes virus infections Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Medicine, Hannover Medical School, Germany Bahram Kasmapour Seighalani Research Topic: Intracellular trafficking of phagosomes and immunity: lessons from mycobacteria Supervisor: Dr. Maximiliano Gutierrez, Department of Vaccinology and Microbiology, Helmholtz Centre for Infection Research Academic Background: MSc Biotechnology, University of Mannheim Anna Pelnikevich Research Topic: Exogenous modulation of virulence in pseudomonas aeruginosa Supervisor: Dr. Lutz Wiehlmann, Department of Molecular Pathology, Hannover Medical School Academic Background: Microbiology, Kazan State University, Russia Malte Sandbaumhüter Research Topic: The function of pUL37 for the cell entry, the assembly and the egress of Herpes Simplex Virus Supervisor: Prof. Dr. Beate Sodeik, Department of Virology, Hannover Medical School Academic Background: Biology, Leibniz University Hannover, Germany Olga Schulz Research Topic: Immune homeostasis in the small intestine: a critical role for constitutive antigen sampling by M cells and dendritic cells Supervisor: Prof. Dr. Oliver Pabst, Institute of Immunology, Hannover Medical School Academic Background: Biomedicine, Hannover Medical School, Germany Christian Stern Research Topic: Tumor targeting of filamentous phages displaying therapeutic molecules by bacterial carriers Supervisor: Dr. Siegfried Weiß, Department of Molecular Immunology, Helmholtz Centre for Infection Research Academic Background: Biology, Rheinische-Friedrich-Wilhelm-University Bonn, Germany Darya Haas (née Stsepanenka) Research Topic: Identification of cellular kinases involved in the reactivation of Kaposi Sarcoma Herpesvirus Supervisor: Prof. Dr. Thomas Schulz, Department of Virology, Hannover Medical School Academic Background: Molecular Biology, Belarusian State University, Minsk, Belarus Elisabeth Wende Research Topic: The role of anaphylatoxin receptors in animal models of experimental colitis Supervisor: Prof. Dr. Andreas Klos, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Medicine, Julius-Maximilians-University Würzburg, Germany Yuri Yakushko Research Topic: Characterization of the pulmonary “virome” in patients at risk for the development of BOS (Bronchiolitits obliterans syndrome) by high throughput sequencing Supervisor: Prof. Dr. Thomas Schulz, Department of Virology, Hannover Medical School Academic Background: Biology, Kyiv National Taras Shevchenko University, Ukraine Graduations 2011 Graduation 21st January 2011 Paulina Blazejewska Research Topic: Genetic susceptibility in mammals to influenza infection Supervisor: Prof. Dr. Klaus Schughart, Experimental Mouse Genetics, Helmholtz Centre for Infection Research, Braunschweig Academic background: Biotechnology, Adam Mickiewicz University Poznan, Poland Ines Hahn Research Topic: Role of phosphoinositide 3-kinase g in the pulmonary host defense against Streptococcus pneumoniae infections Supervisor: PD Dr. Ulrich Maus, Experimental Pneumology, Hannover Medical School Academic Background: Biotechnology, Technical University Braunschweig, Germany Antje Ksienzyk Research Topic: Cellular and molecular analysis of antigen specific immune responses triggered by Interferon Regulatory Factor-1 Supervisor: Dr. Hansjörg Hauser, Molecular Biotechnology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, University of Leipzig, Germany Zofia Magnowska Research Topic: Identification and profiling of antigens from Pseudomonas aeruginosa in clinicalisolates of CF patients by state-of-the-art immunoproteomics Supervisor: Prof. Dr. Jürgen Wehland & Dr. Lothar Jänsch, Cell Biology & Immunology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biotechnology, Jagiellonian University, Cracow, Poland & Environmental Engineering, AGH University of Science and Technology, Cracow, Poland Imke Steffen Research Topic: Signal sequence of HIV-1 glycoprotein: A determinant of posttranslational processing, folding and function? Supervisor: Prof. Dr. Stefan Pöhlmann, Virology, Hannover Medical School Academic Background: Biochemistry, Ruhr-University, Bochum, Germany Jörg Willenborg Research Topic: Role of the arginine deiminase system (ADS) in survival of Streptococcus suis in pigs Supervisor: Prof. Dr. Peter Valentin-Weigand, Institute of Microbiology, University of Veterinary Science Foundation Hannover Academic Background: Plant Biotechnology, Leibniz University Hannover , Germany Graduation 1st July 2011 Wiebke Albrecht Research Topic: The role of USP7 during KSHV latency Supervisor: Prof. Dr. Thomas Schulz, Department of Virology, Hannover Medical School Academic Background: Microbiology, Technical University Braunschweig, Germany Constantin Bode Research Topic:Uncovering the routes of distribution and metabolism of extracellular sphingosine 1-phosphate in vivo and in vitro by imaging and analyzing fluorescently-labelled sphingolipids Supervisor:Dr. Markus Gräler, Institute of Immunology, Hannover Medical School Academic Background: Biochemistry, Leibniz University Hannover, Germany Imke Bargen Research Topic: Establishment of a murine infection model for Mycobacterium paratuberculosis Supervisor: Dr. Siegfried Weiß, Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, Technical University Braunschweig, Germany Tamás Dolowschiák Research Topic: The Role of Polarisation and Horizontal Communication during Proinflammatory Stimulation of Epithelial Cells Supervisor: Prof. Dr. Mathias Hornef, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Biology, University of Pecs, Hungary Henriette Langhans Research Topic:The role of the global transcriptional regulator SlyA for the virulence of enteric Escherichia coli Supervisor:Prof. Dr. Petra Dersch, Department of Microbiology, TU Braunschweig Academic Background:Biology, Technical University Braunschweig, Germany Anja Marquardt Research Topic: In vivo monitoring of MCMV-mutants provoking an altered immune response Supervisor: Prof. Dr. Martin Messerle, Virology, Hannover Medical School Academic Background: Biology, Technical University Braunschweig, Germany Julia Schneider Research Topic: Structure-based design of specific inhibitors for Apicomplexa myosins Supervisor: Prof. Dr. Dietmar Manstein, Institute for Biophysical Chemistry, Hannover Medical School Academic Background: Biochemistry, University of Greifswald, Germany Evgeniya Solodova Research Topic: Role of type I interferons in the innate and adaptive immune defense against Gram-negative bacteria Supervisor: Dr. Siegfried Weiß, Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Natural Sciences, Novosibirsk State University Benjamin Wahl Research Topic: Assessing oral tolerance on the basis of T cell migratory routes Supervisor: Prof. Dr. Oliver Pabst, Institute of Immunology, Hannover Medical School Academic Background: Biochemistry, Leibniz University Hannover, Germany Graduations 2010 Graduation 22nd January 2010 Nadja Bakocevic Research Topic: Functional characterization of follicular T-helper cells and dendritic cells in the gut-associated lymphoid tissue: a two photon microscopy study Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Biochemistry, University of Belgrade, Serbia Nupur Bhatnagar Research Topic: Innate immunity in HIV-1 infection Supervisor: Prof. Dr. Reinhold Schmidt & Dr. Hans Heiken, Department of Clinical Immunology, Hannover Medical School Academic Background: Microbiology (BSc), University of Delhi; Biotechnology (MSc), AIIMS, India Nicole Dietrich Research Topic: Signal induction in host cells by listeriolysin the cholesterol dependent cytolysin of Listeria monocytogenes – consequences of Ca2+ mobilisation Supervisor: Prof. Dr. Siegfried Weiß, Molecular Immunology, Helmholtz-Centre for Infection Research, Braunschweig Academic Background: Biology, Technical University Braunschweig, Germany Jan Hänisch Research Topic: Signal dependent activation of actin-polymerisation during Salmonella invasion Supervisor: Dr. Theresia Stradal, Signalling and Motility Group, Helmholtz Centre for Infection Research, Braunschweig Academic background: Biotechnology, University of Münster, Germany Florian Klauschies Research Topic: Infection of the respiratory epithelium by Canine distemper virus: importance of lipid rafts for virus entry and exit Supervisor: Prof. Dr. Georg Herrler & Prof. Dr. Ludwig Haas, Institute for Virology, University of Veterinary Medicine Hannover, Foundation Academic Background: Biology, J.W. Goethe University Frankfurt, Germany Manju Nagarajan Research Topic: Molecular aspects for the control of immune surveillance by blood-borne sphingosine 1- phosphate (S1P) Supervisor: Dr. Markus Gräler, Institute of Immunology, Hannover Medical School Academic Background: Genomics (MSc), Madurai Kamaraj University, India & Biochemistry/Biotechnology (BSc), Bharathiyar University, India Quan Qiu Research Topic: Role of the receptor for poliovirus/CD 155 in the differentiation of T cells. T cells as putative reservoir for poliovirus replication Supervisor: Dr. Günter Bernhardt, Institute of Immunology, Hannover Medical School Academic Background: Biochemistry & Molecular Biology (MSc), Shanghai Second Medical University; Biotechnology (BSc), Soochow University, China Fabienne Rehren Research Topic: Inhibition of the Coxackievirus B3 induced Cytokine Expression by Interleukin 1 Receptor Antagonist Supervisor: PD Dr. med. Albert Heim, Dept. of Virology, Hannover Medical School Academic Background: Biochemistry, Leibniz University Hannover, Germany Julia Schipke Research Topic: Mutation of the large tegument protein VP1-3 of Herpes Simplex Virus Type 1 Supervisor: PD Dr. Beate Sodeik, Department of Virology, Hannover Medical School Academic Background: Biology, Leibniz University Hannover, Germany Swati Shukla Research Topic: Influence of intestinal bacteria on the antibody repertoire of B-1 cells. Supervisor: Dr. Siegfried Weiss, Research Group Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biochemistry (BSc) & Biomedical Sciences (MSc), University of Delhi, India Rachel Thomas Research Topic: Genetic susceptibility factors associated with HIV-1 disease progession and CMV reactivation in co-infected patients Supervisor: Prof. Dr. Thorsten Witte, Dept. of Clinical Immunology, Hannover Medical School Academic Background: Environmental Technology and Management (MSc), De Montfort University, England & Biological Sciences (BSc), University of Guelph, Canada Graduation 18th June 2010 Christiane Brohm Research Topic: Molecular Interactions in the course of hepatitis C virus assembly Supervisor: Prof. Dr. Thomas Pietschmann, Department for Experimental Virology, Twincore Center, Hannover Academic Background: Biology, Ruprechts-Karls-University, Heidelberg, Germany Sirine El Houry Research Topic: The DNA polymerase III holoenzyme of Pseudomonas aeruginosa Supervisor: Dr. Ute Curth, Institute for Biophsical Chemistry, Hannover Medical School Academic Background: Molecular and Cell Biology (MSc), Pasteur Institute, Paris, France & Biology (BSc), American University of Beirut, Lebanon Anika Hävemeier Research Topic: The role of KSHV K15 in B cell maturation Supervisor: Prof. Dr. Thomas Schulz, Department of Virology, Hannover Medical School Academic Background: Biology, Leibniz University Hannover, Germany Swantje Hammerschmidt Research Topic: Elucidating the role of intestinal plasmacytoid dendritic cells during infection and inflammation Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic background: Biochemistry, Leibniz University Hannover, Germany Sonja Horatzek Research Topic: Metabolic control of virulence in Pseudomona aeruginosa Supervisor: Prof. Dr. Burkhard Tümmler & Dr. Lutz Wiehlmann, Clinical Research Group, Molecular Pathology, Hannover Medical School Academic Background: Biology, Technical University Braunschweig, Germany Rajesh Kolli Research Topic: Analyses of Hepatitis C virus-host cell interactions by live cell microscopy Supervisor: Dr. Benno Woelk, Dept . of Virology, Hannover Medical School Academic Background: Biotechnology (MTech), Jawaharlal Nehru Technological University, India & Pharmacy (B.Pharm), V. Bharati College of Pharmaceutical Sciences, India Anna Leibo Research Topic: Immune evasion, suppression and polarization by pathogenic Heliobacter species Supervisor: PD Dr. Christine Josenhans, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Microbiology, Moscow Lomonosov State University, Russia Claudia Moccia Research Topic: Mechanisms of Helicobacter pylori to generate genetic variability during chronic infection Supervisor: Prof. Dr. Sebastian Suerbaum, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Biology, University Simón Bolívar, Caracas, Venezuela & Mayor de San Andrés de la Paz University, La Paz, Bolivia Miriam Nörder Research Topic: Development of mice containing the human immune system and/or human liver for the preclinical validation of vaccine candidates Supervisor: Prof. Dr. Carlos Guzmán, Department of Vaccinology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, Carl-von-Ossietzky-University Oldenburg, Germany Ulfert Rand Research Topic: Monitoring the IFN response upon infection Supervisor: Dr. Hansjörg Hauser, Department of Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, Carl-von-Ossietzky-University Oldenburg, Germany Anchana Rathinasamy Research Topic: Sphingosine-1 phosphate – a novel regulator of dendritic cell traffic and positioning during the course of infection Supervisor: Prof. Dr. Oliver Pabst, Institute of Immunology, Hannover Medical School Academic Background: Biotechnology (MSc) University of Madras, India & Microbiology (BSc) Bharathidasan University, India Barkha Srivastava Research Topic: Immunogenetics of the host response to Influenza A infection Supervisor: Prof. Dr. Klaus Schughart, Experimental Mouse Genetics, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biotechnology, Barkatullah University Bhopal, India and Parasitology, McGill University, Montreal, Canada Graduations 2009 Graduation 30th January 2009 Janet Krege Research Topic: The role of the immune system of the upper respiratory tract in immunity and tolerance Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Biochemistry/Molecular Biology, Friedrich Schiller University Jena, Germany Sara Bartels (neé Leschner) Research Topic: Tumor specific gene expression by Salmonella enterica serovar Typhiumurium Supervisor: Dr. Siegfried Weiss, Research Group Molecular Immmunology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, University of Hohenheim, Germany Julia Micklinghoff Research Topic: Pathogenesis of tuberculosis Supervisor: Prof. Dr. Franz-Christoph Bange, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Pharmacy, Technical University Braunschweig, Germany Florence Njau Research Topic: Effects of TNF alpha receptor blockage on C. pneumoniae-infected dendritic cells in vitro and in vivo Supervisor: Dr. Anette Wagner, Department of Rheumatology, Hannover Medical School Academic Background: Veterinary Medicine (BSc), Sokoine University of Agriculture, Tanzania; Molecular Biology (MSc), Free University of Brussels, Belgium Girish Ramachandran Research Topic: Functional characterization of Streptococcus suis OFS – protein. Supervisor: Prof. Dr. Peter Valentin-Weigand, Institute for Microbiology and Infectious Diseases, University of Veterinary Medicine, Hannover Academic Background: Biotechnology (BSc), Dr. G.R.D College of Science, India; MSc Human Genetics, Sri Ramachandra Medical College & Research Institute, India; Molecular Genetics (MSc), University of Leicester, England Melanie Rust Research Topic: Helicobacter type III secretion system: Protein secretion, protein interaction and gene regulation Supervisor: Prof. Dr. Christine Josenhans, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Biology, Leibniz University Hannover, Germany Malgorzata Szczodrak Research Topic: Dissection of dynamic actin rearrangements during host-pathogen interaction Supervisor: Dr. Klemens Rottner, Research Group Cytoskeleton Dynamics, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biotechnology & Molecular Biology, University of Agriculture, Poland Milena Tosiek Research Topic: Molecular and functional characterisation of regulatory T cells in infectious disease and autoimmunity Supervisor: Prof. Dr. Jan Buer, Research Group in Mucosal Immunity, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Pharmacy, Medical University of Lodz, Poland Graduation 26th June 2009 Mandy Glaß Research Topic: Characterization of the essential cytomegalovirus protein pUL77 as basis for the development of new antivirals and of a replication-deficient DISC-vaccine Supervisor: Prof. Dr. Martin Messerle, Department of Virology, Hannover Medical School Academic background: Biochemistry, Martin Luther University Halle-Wittenberg, Germany Jessica Janus Research Topic: Identification of host and viral factors mediating axonal transport of herpes simplex virus type 1 Supervisor: PD Dr. Beate Sodeik, Department of Virology, Hannover Medical School Academic Background: Biology, Leibniz University Hannover, Germany Lydia Janus Research Topic: Transmission of Mice Minute Virus in mouse population Supervisor: Prof. Dr. Hans-Jürgen Hedrich, Central Animal Laboratory, Hannover Medical School Academic Background: Veterinary Medicine, University of Veterinary Medicine Hannover, Foundation, Germany Vanessa Jensen Research Topic: Influence of environmental factors on intercellular signaling and secondary metabolite production in Pseudomonas aeruginosa Supervisor: Dr. Susanne Häußler, Research Group Cell Biology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, University of Bielefeld & University of Kiel, Germany Stefan Pachnicke Research Topic: Molecular mechanisms of anthelmintic resistance Supervisor: Prof. Dr. Georg von Samson-Himmelstjerna, Institute of Parasitology, University of Veterinary Medicine Hannover, Foundation Academic Background: Veterinary Medicine, University of Veterinary Medicine Hannover, Foundation, Germany Marcel Pietrek Research Topic: Characterization of proximal elements in the signaling cascade induced by KSHV K15 Supervisor: Prof. Dr. Thomas Schulz, Department of Virology, Hannover Medical School Academic Background: Biology, Leibniz University Hannover, Germany Halina Tegetmeyer Research Topic: Functional characterization of the autotransporter adhesins of Actinobacillus pleuropneumoniae Supervisor: Prof. Dr. Nina Baltes, Institute for Microbiology and Infectious Diseases, University of Veterinary Medicine Hannover, Foundation Academic Background: Biology, University of Dresden, Germany Sarvari Velaga Research Topic: Structure, organogenesis and function of solitary intestinal lymphoid tissue Supervisor: Prof. Dr. Oliver Pabst, Institute of Immunology, Hannover Medical School Academic Background: Molecular Biology, Osmania University, Hyderabad, India & University of Skövde /Karolinska Institute, Sweden Tetyana Yevsa Research Topic: Development of a Bordetella bronchiseptica-based technology platform to deliver vaccine antigens by the mucosal route Supervisor: Prof. Dr. Carlos Guzmán, Research Group Vaccine Research, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Microbiology, Odessa National University, Ukraine Graduations 2008 Graduation 25th Janary 2008 Maike de Buhr Research Topic: Analysis of Cd14 as a candidate gene for experimental inflammatory bowel disease Supervisor: Prof. Hans-Jürgen Hedrich, Central Animal Laboratory, Hannover Medical School Academic Background: Biology, University of Münster, Germany & University of Edinburgh, Scotland Nicolas Fasnacht Research Topic: Analysis of infection of mice with Trichuris muris Supervisor: Dr. Werner Müller, Research Group Experimental Immunology, Helmholtz Centre for Infection Research, Braunschweig Academic background: Chemical Engineering/Biotechnology, Swiss Federal Institute of Technology, Lausanne (EPFL), Switzerland Kay Johswich Research Topic: Cell responses to inflammatory mediators and bacterial pathogens Supervisor: Prof. Dr. Andreas Klos, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Biochemistry, Leibniz University Hannover, Germany Priyanka Narang Research Topic: The reaction of the innate immune system towards an infection with the pathogenic fungus Aspergillus fumigatus Supervisor: Dr. Matthias Gunzer, Research Group Immunodynamics, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biomedical Science (BSc), University of Delhi; Biotechnology (MSc), AIIMS, New Delhi, India Peter Reichardt Research Topic: T-cell activation by varying antigen presenting cells (APC) and by altered peptide ligands - consequences in vitro und in vivo Supervisor: Dr. Matthias Gunzer, Research Group Immunodynamics, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Human Medicine, University of Leipzig, Germany Sebastian Seth Research Topic: Analyzing the function of CD155 in T cell priming and differentiation Supervisor: Dr. Günter Bernhardt, Institute of Immunology, Hannover Medical School Academic Background: Biochemistry, Leibniz University Hannover, Germany Jessica Thalmann Research Topic: Functional characterization of chlamydia trachomatis protein CT166 and host cell response in chlamydial persistence Supervisor: Prof. Dr. Andreas Klos, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Biochemistry, Leibniz University Hannover, Germany Stefanie Weiß Research Topic: Purification and characterisation of N- WASP and WASP associated protein complexes Supervisor: Dr. Theresia Stradal, Research Group Signaling and Motility, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biochemistry, University of Tübingen, Germany Graduation 27th June 2008 Vanessa Barroso Research Topic: Interaction of extracellular matrix components with group C and G streptococci Supervisor: Prof. Dr. Singh Chhatwal, Research Group Microbial Pathogenicity, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Microbial Biology and Genetics, University of Lisbon, Portugal Davide Ferraris Research Topic: Structural analysis of host-pathogen interaction Supervisor: Prof. Dr. Dirk Heinz, Research Group Structural Biology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Chemistry, University of Turin, Italy Julia Heinzmann Research Topic: Functional characterisation of a 38Kb pathogenicity island of Mycobacterium avium subspecies paratuberculosis Supervisor: Prof. Dr. Gerald-F. Gerlach, Department of Infectious Diseases, Institute for Microbiology, University of Veterinary Medicine Hannover, Foundation Academic Background: Biology, University of Konstanz, Germany Marcin Lyszkiewicz Research Topic: Imaging of early events during Listeria monocytogenes infection in the intact spleen Supervisor: Dr. Siegfried Weiss, Research Group Molecular Immunology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biotechnology & Immunology, University of Wroclaw, Poland Patrick Olbermann Research Topic: Helicobacter pylori virulence factors: Aspects of bacterial variability, host response and adaption Supervisor: Prof. Dr. Christine Josenhans, Department of Medical Microbiology and Hospital Epidemiology, Hannover Medical School Academic Background: Biology, Georg August University Göttingen, Germany Julia Pulverer Research Topic: Imaging activation of the interferon system Supervisor: Dr. Hansjörg Hauser, Research Group Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biotechnology and Food Engineering, University of Agricultural Science, Vienna, Austria Kerstin Radtke Research Topic: Biochemical characterization of Herpes Simplex Virus receptors for the microtubule motors dynein and kinesin Supervisor: Prof. Dr. Beate Sodeik, Department of Virology, Hannover Medical School Academic Background: Biochemistry, Leibniz University Hannover, Germany Upneet Sandhu Research Topic: Establishment of a mouse immunisation model for strictly controlled antigen expression Supervisor: Dr. Dagmar Wirth, Research Group Gene Regulation and Differentiation, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Microbiology & Biochemistry (BSc), University of Mumbai, India / Biotechnology (MSc), University of Essex, UK Sven Christian Sensken Research Topic: Signaltransduction of sphingosine 1-phosphate (S1P) and its receptor S1P1 in the immune system Supervisor: Dr. Markus Gräler, Institute of Immunology, Hannover Medical School Academic Background: Biochemistry, University of Bielefeld, Germany Nuno Viegas Research Topic: In vivo function of listeriolysin in the murine spleen during the early phase of Listeria moncytogenes infection Supervisor: Dr. Siegfried Weiss, Research Group Molecular Immmunology, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biotechnological Engineering, University of the Algarve, Portugal Caroline Zaoui Research Topic: Intercellular communication in Pseudomonas aeruginosa: analysis of the molecular mechanism underlying the Pseudomonas quinolone signal (PQS) transduction Supervisor: Prof. Dr. Jürgen Wehland, Research Group Cell Biology & Dr. Susanne Häußler, Research Group Chronic Pseudomonas Diseases, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biochemistry (BSc), Claude Bernard University, Lyon 1 (France); Microbiology (MSc) René Descartes University, Paris 5 (France) Beata Zygmunt Research Topic: Development and characterization of novel vaccine candidates against HCV Supervisor: Prof. Dr. Carlos Guzmán, Research Group Vaccine Research, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Molecular Biology, University of Warsaw, Poland & International Max Planck Research School, Göttingen, Germany Graduations 2007 Graduation 16th February 2007 Eva Gellermann (neé Brüning) Research Topic: Identification and functional characterisation of intracellular interaction partners of the KSHV (Kaposi’s sarcoma-associated herpesvirus) latency-associated nuclear antigen (LANA-1) protein. Supervisor: Prof. Dr. Thomas F. Schulz, Department of Virology, Hannover MedicalSchool , Germany Academic Background: Biology, Hannover Medical School Michael Düwel Research Topic: Functional properties of the Coated Vesicle-Associated-Kinase of 104 kDa (CVAK104) in clathrin-mediated vesicular trafficking Supervisor: Prof. Dr. Ernst Ungewickell , Department of Cell Biology, Center for Anatomy, Hannover Medical School Academic Background: Biochemistry, Leibniz University Hannover, Germany Heidi Imhoff Research Topic: The Role of Lipid Rafts in Canine Distemper Virus Infection Supervisor: Prof. Dr. Georg Herrler & Prof. Dr. Ludwig Haas, Institute of Virology, University of Veterinary Medicine Hannover, Foundation Academic background: Biology, RWTH Aachen University, Germany Susanne Lerch Research Topic: Epitope mapping of the Classical Swine Fever Virus glycoprotein E2 Supervisor: Prof. Dr. Volker Moennig, Institute of Virology, University of Veterinary Medicine Hannover Foundation Academic Background: Biology, Johannes Gutenberg University Mainz, Germany Petra Lüthje Research Topic: Molecular basis of pirlimycin resistance in coagulase-negative staphylococci isolated from cases of bovine mastitis Supervisor: Prof. Dr. Stefan Schwarz, Institute for Animal Breeding, Federal Agricultural Research Centre (FAL), Mariensee Academic Background: Veterinary Medicine, University of Veterinary Medicine Hannover, Foundation, Germany Simone Reinwald Research Topic: Molecular and Functional Characterization of regulatory T cells – Tracing new molecules associated with regulatory phenotype Supervisor: Prof. Dr. Jan Buer, Junior Research Group in Mucosal Immunity, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, Technical University Braunschweig, Germany Kristina Theusner Research Topic: Herpes Simplex Virus triggers Myosin II Activation during Cell Entry Supervisor: PD Dr. Beate Sodeik, Department of Virology, Hannover Medical School Academic Background: Applied Biochemistry and Molecular Biology ( BSc), University of the West of England, Bristol, UK ; Molecular Biology (MSc), Georg August University Göttingen, Germany Ulrike Wittkop Research Topic: Characteristics of Chlamydophila pneumoniae infection in human dendritic cells Supervisor: Dr. Annette Wagner, Department of Rheumatology, Hannover Medical School Academic Background: Biology, Leibniz University Hannover, Germany Tim Worbs Research Topic: Chemokine Receptor CCR7 contributes to intranodal T cell motility and functional organization of the intestinal immune system Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Biotechnology, Technical University Braunschweig, Germany Graduation 6th July 2007 Simon Berberich Research Topic: Dynamic expression of chemokine receptors and integrins regulate B cell migration between the peritoneal cavity and the periphery Supervisor: Prof. Dr. Reinhold Förster, Institute of Immunology, Hannover Medical School Academic Background: Biochemistry, Johann Wolfgang Goethe University Frankfurt & Leibniz University Hannover, Germany Tanja Bosse Research Topic: Dissection of Rho-GTPase function in c-Met-induced actin reorganization Supervisor: Dr. Klemens Rottner, Research Group Cytoskeleton Dynamics, Helmholtz Centre for Infection Research, Braunschweig Academic Background: Biology, Technical University Braunschweig, Germany Maren Mönkemeyer Research Topic: New pathogenic immune mechanisms in viral coinfections with Human Immunodeficiency Virus (HIV)-1 – Role of apoptosis and genetic susceptibility Supervisor: Prof. Dr. Reinhold Schmidt, Department of Clinical Immunology, Hannover Medical School Academic background: Biology, Leibniz University Hannover, Germany Angelika Waltermann Research Topic: The identification, subcellular localization and functional characterization of 6K1 of plum pox virus and other members of the genus Potyvirus Supervisor: Prof. Dr. Edgar Maiss, Institute of Plant Diseases and Plant Protection, Leibniz University Hannover Academic Background: Human Biology, Philipps University Marburg, Germany Claudia Welz Research Topic: Identification, characterization, and expression of latrophilin-like proteins in parasitic nematodes Supervisor: Prof. Dr. Georg von Samson-Himmelstjerna, Institute for Parasitology, University of Veterinary Medicine Hannover, Foundation Academic Background: Veterinary Medicine, University of Veterinary Medicine Hannover, Foundation, Germany

Publikationen des Instituts seit 1997 2026 Froese,Natali ; Shymotiuk,Ivanna ; Froese,Alexander ; Polten,Felix ; Jablinski,Jonas ; Scholz,Tim ; Korf-Klingebiel,Mortimer ; Werlein,Christopher ; Galuppo,Paolo ; Gigina,Anna ; Wihler,Katharina ; Schneider,Johanna ; Erschow,Sergej ; Heimerl,Maren ; Szaroszyk,Malgorzata ; Hegermann,Jan ; Wrede,Christoph ; Schweitzer,Theresa ; Pich,Andreas ; Geffers,Robert ; Ricke-Hoch,Melanie ; Kühnel,Mark P. ; Jonigk,Danny D. ; Wende,Adam R. ; Abel,E. Dale ; Nikolaev,Viacheslav O. ; Wollert,Kai C. ; Bauersachs,Johann ; Riehle,Christian ; RHOT Proteins Link Mitochondrial Motility to Cardiomyocyte Sarcomere Maturation Circ.Res., 2026, 138(9), e327297-, Originalpublikation Hartmann,Carla ; Haferkamp,Undine ; Appelt-Menzel,Antje ; Barenberg,Janica ; Brachner,Andreas ; Ehrhard,Toni ; Feldhaus,Julia ; Gerhartl,Anna ; Hollemann,Thomas ; Kulka,Linda Anna Michelle ; Leckzik,Selin ; Leu,Jennifer ; Woo,Marcel Seungsu ; Friese,Manuel Alexander ; Initiative,Alzheimer's Disease Neuroimaging ; Metzger,Marco ; Neuhaus,Winfried ; Oerter,Sabrina ; Olzscha,Heidi ; Pich,Andreas ; Riemann,Dagmar ; Pless,Ole ; Rujescu,Dan ; Jung,Matthias ; Brain capillary endothelial-like cells show altered barrier functionality and reduced transport of amyloid β in late-onset Alzheimer disease Fluids Barriers CNS, 2026, 23(1), 11- , Originalpublikation Kampelmann,Morten ; Pich,Andreas ; Mühlfeld,Christian ; Schipke,Julia ; Diet-induced obesity alleviates epithelial damage in hyperoxic acute lung injury (HALI) in mice Respir.Res., 2026, (), - , Originalpublikation Langejürgen,Anna ; Schmidt,Gudula ; Unsöld,Leon ; Tatge,Helma ; Oyson,Ethel ; Gerhard,Ralf ; Interference of Large Clostridial Glucosyltransferases with the Endolysosomal Pathway: Toxin-Induced Imbalance of Early Endosomes, Functional Lysosomes and Autophagosomes Toxins (Basel), 2026, 18(4), 186- , Originalpublikation Langejürgen,Anna ; Characterizing endosomal homeostasis disruption and lysosomal dysfunction triggered by endosomal escape of AB toxins : a study on clostridioides difficile toxin B, 2025, Dissertation Polten,Felix ; Sandu,Mircea-Andrei ; Faix,Jan ; Hegermann,Jan ; Kriedemann,Nils ; Zweigerdt,Robert ; Thum,Thomas ; Bauersachs,Johann ; Niessen,Hans W. ; Koenig,Andrew L. ; Lavine,Kory J. ; Pich,Andreas ; Wang,Yong ; Reboll,Marc R. ; Korf-Klingebiel,Mortimer ; Wollert,Kai C. ; Extracellular BRICK1 drives heart repair after myocardial infarction in mice, United States,Sci.Transl.Med.,2026;18(831):eadx2876 Originalpublikation Schenke,Maren ; Westphal,Alice ; Weisemann,Jasmin ; Rummel,Andreas ; Dorner,Brigitte G. ; Klawonn,Frank ; Seeger,Bettina ; High sensitivity of iPSC-derived motor neurons to the human-relevant botulinum neurotoxin serotypes E and F Neurotoxicology, 2026, 114(), 103446- , Originalpublikation 2025 Bai,Yiling ; Wu,Zhaojia ; Leary,Scot C. ; Fang,Chen ; Yu,Michelle ; Genth,Harald ; Xie,Yufeng ; Shi,Jinhui ; Xiang,Jim ; Focal Adhesion Kinase Alleviates Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation by Activating Transcriptional Wnt/β-Catenin-BMP2-COL1 and Metabolic SIRT1-PGC-1α-CPT1A Pathways, Switzerland,Int.J.Mol.Sci.,2025;26(4):1669 Originalpublikation Bellmann,Denise ; Evaluation of the neutralizing activity of newly developed equine antibodies against C. botulinum neurotoxins using in vitro differentiated P19 neurons, Hannover,,2025;() Masterarbeit Bollenbach,Alexander ; Beckmann,Bibiana ; Tsikas,Dimitrios ; Quality control in GC-MS analysis of amino acids in human urine and plasma: Possible implications for targeted and untargeted metabolomics, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1262():124661 Originalpublikation Bünermann,Ines ; Detering,Nora ; Tapken,Ines ; Kuhn,Daniela ; Jahn,Kirsten ; Burkert,Alexandra ; Naczinsky,Sarah ; Hensel,Niko ; Schüning,Tobias ; Dittrich-Breiholz,Oliver ; Pich,Andreas ; Claus,Peter ; Alterations along the neuroendocrine axis of leptin homeostasis: white adipose tissue and hypothalamus in a severe SMA mouse model, England,Hum.Mol.Genet.,2025;():- Originalpublikation Chung,Bomee ; Jonas,Wenke ; Rostami,Fatemeh ; Malik,Zulaikha ; Szaroszyk,Malgorzata ; Levay,Magdolna ; Thackeray,James ; Ost,Mario ; Nowak,Steven ; Hegermann,Jan ; Wieland,Thomas ; Pich,Andreas ; Bengel,Frank M. ; Bauersachs,Johann ; Wollert,Kai C. ; Heineke,Joerg ; Schürmann,Annette ; Kempf,Tibor Iron regulatory proteins secure iron availability in skeletal muscle to preserve exercise tolerance in heart failure England,Cardiovasc.Res.,2025;() Originalpublikation Chung,Soo-Young ; Die Bedeutung konservierter Cysteine für die Funktion der Clostridium difficile Toxine A und B, Hannover,,2024;():4 ungezählte Blätter, 45 Blätter Dissertation Dastagir,Nadjib ; Liebsch,Christina ; Kutz,Jaqueline ; Wronski,Sabine ; Pich,Andreas ; Obed,Doha ; Vogt,Peter Maria ; Bucan,Vesna ; Strauß,Sarah ; Identification of antimicrobial peptides from the Ambystoma mexicanum displaying antibacterial and antitumor activity, United States,PLoS One,2025;20(3):-e0316257 Originalpublikation Dettmann,Paulin ; Skiba,Martin ; Stern,Daniel ; Weisemann,Jasmin ; Mages,Hans Werner ; Krez,Nadja ; Dorner,Martin B. ; Schaarschmidt,Sara ; Avondet,Marc A. ; Fulde,Marcus ; Rummel,Andreas ; Strommenger,Birgit ; Maurischat,Sven ; Dorner,Brigitte G. ; Highly Sensitive Suspension Immunoassay for Multiplex Detection, Differentiation, and Quantification of Eight Staphylococcus aureus Enterotoxins (SEA to SEI), Switzerland,Toxins (Basel),2025;17(6):265-http://doi.org/10.3390/toxins17060265 Originalpublikation Dietz-Ziegler,Stefanie ; Kewitz,Samantha ; Kaiser,Gabriele ; Rühle,Jessica ; Marmé,Alexander ; Dalpke,Alexander ; Cheaib,Bachar ; Pauluschke-Fröhlich,Jan ; Henes,Melanie ; Velic,Ana ; Pich,Andreas ; Vollert,Anneli ; Schaller,Martin ; Knab,Felix ; Lajqi,Trim ; Poets,Christian F. ; Gille,Christian ; Köstlin-Gille,Natascha Extracellular Vesicles Derived From the Feces of Pregnant Women Modulate T Cells Toward a Pregnancy-Supportive Phenotype In Vitro, Germany,Eur.J.Immunol.,2025;55(9):e70056 Originalpublikation Frommeyer,Yannick N. ; Gomez,Nicolas O. ; Preusse,Matthias ; Arce-Rodriguez,Alejandro ; Neubauer,Kerstin ; Kennepohl,Benedikt ; Witte,Julius ; Bouheraoua,Safaa ; Cetraro,Pierina ; Erdmann,Jelena ; Neumann-Schaal,Meina ; Müsken,Mathias ; Pich,Andreas ; Bähre,Heike ; Depledge,Daniel P. ; Häussler,Susanne ; tRNA hydroxylation is an epitranscriptomic modulator of metabolic states affecting Pseudomonas aeruginosa pathogenicity, England,Nucleic Acids Res.,2025;53(14):gkaf719 Originalpublikation Gand,Luis Vincens ; Lanzuolo,Chiara ; Li,Mugeng ; Rosti,Valentina ; Weber,Natalie ; Lu,Dongchao ; Bär,Christian ; Thum,Thomas ; Pich,Andreas ; Kraft,Theresia ; Amrute-Nayak,Mamta ; Nayak,Arnab ; Calcium Handling Machinery and Sarcomere Assembly are Impaired Through Multipronged Mechanisms in Cancer Cytokine-Induced Cachexia, Germany,J.Cachexia Sarcopenia Muscle,2025;16(2):-e13776 Originalpublikation Gao,Linfeng ; Nowakowska,Maria Barbara ; Selby,Katja ; Przykopanski,Adina ; Chen,Baohua ; Krüger,Maren ; Douillard,François Paul ; Lam,Kwok-Ho ; Chen,Peng ; Huang,Ting ; Minton,Nigel Peter ; Dorner,Martin Bernhard ; Dorner,Brigitte Gertrud ; Rummel,Andreas ; Lindström,Miia ; Jin,Rongsheng ; Botulinum neurotoxins exploit host digestive proteases to boost their oral toxicity via activating OrfXs/P47, United States,Nat.Struct.Mol.Biol.,2025;():- Originalpublikation Hage,David S. ; Liu,Huwei ; Theodoridis,Georgios ; Tsikas,Dimitrios ; Virgilliou,Christina ; Wilson,Ian ; Chemical analysis-relating nomenclature issues in the Journal of Chromatography B, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1263():124703 Originalpublikation Hage,David S. ; Liu,Huwei ; Theodoridis,Georgios ; Tsikas,Dimitrios ; Virgilliou,Christina ; Wilson,Ian D. ; Refreshing the Aims and Scope of the Journal of Chromatography B J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci., 2026, 1269(), 124865- , Editorial Heimerl,Maren ; Erschow,Sergej ; Müller-Olling,Mirco ; Manstein,Dietmar J. ; Decher,Niels ; Kauferstein,Silke ; Jenewein,Tina ; Pich,Andreas ; Ricke-Hoch,Melanie ; Hilfiker-Kleiner,Denise ; Cardiac dysfunction related to cardiac mRNA and protein traffic impairment due to reduced unconventional motor protein myosin-5b expression, England,Eur.Heart J.,2025;(): Originalpublikation Horn,Vanessa ; Zarnovican,Patricia ; Tiemann,Birgit ; Pich,Andreas ; Bakker,Hans ; Routier,Françoise H. ; N-Glycoproteomics of the Apicomplexan Parasite Toxoplasma gondii, Germany,,2025;():-e202400239 Originalpublikation Ibrahim,Nurul Khalida ; Schreek,Sabine ; Cinar,Buesra ; Stasche,Anna Sophie ; Lee,Su Hyun ; Zeug,Andre ; Dolgner,Tim ; Niessen,Julia ; Ponimaskin,Evgeni ; Shcherbata,Halyna ; Fehlhaber,Beate ; Bourquin,Jean-Pierre ; Bornhauser,Beat ; Stanulla,Martin ; Pich,Andreas ; Gutierrez,Alejandro ; Hinze,Laura ; SOD2 is a regulator of proteasomal degradation promoting an adaptive cellular starvation response, United States,Cell.Rep.,2025;44(4): Originalpublikation Jordan,Maria ; Schmidt,Kevin ; Fuchs,Maximilian ; Just,Annette ; Pfanne,Angelika ; Willmer,Lena ; Neubert,Lavinia ; Werlein,Christopher ; Zardo,Patrick ; Pich,Andreas ; Thum,Thomas ; Fiedler,Jan ; Repurposing of the small-molecule adrenoreceptor-inhibitor carvedilol for treatment of the fibrotic lung, Switzerland,Front.Pharmacol.,2025;16():1534989 Originalpublikation Josuran,Roland ; Wenger,Andreas ; Worbs,Sylvia ; Kampa,Bettina ; Rummel,Andreas ; Dorner,Brigitte G. ; Gerber,Sabina ; N-Glycosylation Profile of Abrin Certified EU Reference Material, Switzerland,Toxins (Basel),2025;17(3):108 Originalpublikation Kaiser,Annette ; Agostinelli,Enzo ; Tsikas,Dimitrios The hypusine pathway in Ixodes ricinus: molecular cloning and validation of deoxyhypusine synthase as a novel target for drug discovery to treat and prevent vector borne diseases Switzerland,Front.Cell.Infect.Microbiol.,2025;15():1638906 Originalpublikation Kroh,Amelie ; Charakterisierung der nichttoxischen OrfX-Proteine 1-3 sowie P47 aus Clostridium botulinum Serotyp E Subtyp E1 Stamm Beluga, Hannover,,2024;():XII, 154 Blätter, Blatt XIII-XX : Illustrationen, Diagramme Dissertation Lam,Kwok-Ho ; Gao,Linfeng ; Przykopanski,Adina ; Chen,Baohua ; Huang,Ting ; Krüger,Maren ; Bartels,Anna-Magdalena ; Dorner,Martin Bernhard ; Perry,Kay ; Dorner,Brigitte Gertrud ; Rummel,Andreas ; Jin,Rongsheng ; A nut-and-bolt assembly of the bimodular large progenitor botulinum neurotoxin complex, United States,Sci.Adv.,2025;11(35):eadx5831 Originalpublikation Masuyer,Geoffrey ; Rummel,Andreas ; Stenmark,Pål ; Botulinum neurotoxin A mutants with enhanced ganglioside binding show improved potency and altered ganglioside selectivity, England,Commun.Chem.,2025;8(1):171 Originalpublikation Ostermann,Lena ; Seeliger,Benjamin ; Peukert,Konrad ; Steinmetz,Lara-Kristin ; Flasche,Carolin ; Maus,Regina ; Stolper,Jennifer ; Vogl,Thomas ; Pich,Andreas ; Bode,Christian ; Neumann,Konstantin ; Brand,Korbinian ; Tessier,Philippe A. ; Roth,Johannes ; Maus,Ulrich A. ; Lack of S100A8 impairs lung protective immunity against Streptococcus pneumoniae, United States,J.Infect.Dis.,2025;() Originalpublikation Paulmann,Volker ; Mikuteit,Marie ; Just,Ingo ; Karmann,Naomi ; Steffens,Sandra ; The science module in the MHH's model curriculum - development, implementation, results, Germany,GMS J.Med.Educ.,2025;42(5):Doc59 Originalpublikation Ramachandran,Dhanya ; Dewender,Robin Tarek ; Schröder-Heurich,Bianca ; Froböse,Wiebke ; Avdulahu,Florian ; Richter,Katja ; Baker,Valerie L. ; Winn,Virginia D. ; Pich,Andreas ; von Versen-Höynck,Frauke Exploring the plasma proteome linked to corpus luteum presence and conception mode across pregnancy stages and postpartum Netherlands,J.Assist.Reprod.Genet.,2025 Originalpublikation Schmidt,Arne ; Schmidt,Kevin ; Groß,Sonja ; Lu,Dongchao ; Xiao,Ke ; Neufeldt,Dimyana ; Cushman,Sarah ; Lehmann,Nele ; Thum,Sabrina ; Pfanne,Angelika ; Just,Annette ; Pich,Andreas ; Heinz,Alexander ; Hiller,Karsten ; Hunkler,Hannah Jill ; Tan,Wilson Lek Wen ; Foo,Roger ; Bär,Christian ; Thum,Thomas ; Jung,Mira ; Circular RNA circIGF1R controls cardiac fibroblast proliferation through regulation of carbohydrate metabolism, England,Sci.Rep.,2025;15(1):20331 Originalpublikation Smandzich,Nadine J. ; Pich,Andreas ; Gschwendtberger,Thomas ; Greten,Stephan ; Ye,Lan ; Klietz,Martin ; Di Fonzo,Alessio ; Henkel,Lisa M. ; Wegner,Florian Proteomics of Patient-Derived Striatal Medium Spiny Neurons in Multiple System Atrophy Switzerland,,2025;14(17):1394 Originalpublikation Steinberg,Maximilian ; Wilk,Laura-Varenne ; Stern,Daniel ; Weisemann,Jasmin ; Messelhäußer,Ute ; Wittwer,Matthias ; Krüger,Maren ; Mages,Hans Werner ; Rummel,Andreas ; Dorner,Martin B. ; Dorner,Brigitte G. ; Validation of an Endopep-suspension immunoassay for the diagnostics of human botulism, Germany,ALTEX,2025;(): Originalpublikation Tammen,Harald ; Pich,Andreas ; Hess,Rüdiger ; Lechowicz,Urszula ; Janciauskiene,Sabina ; Chorostowska,Joanna ; Quantitative mass spectrometric analysis of C-terminal 36 amino acid peptides of alpha-1 antitrypsin in plasma using survey spectra, United States,Methods,2025;240():7-13 Originalpublikation Tsikas,Dimitrios ; Analysis of eicosanoids by quadrupole gas chromatography-negative ion chemical ionization-tandem mass spectrometry as pentafluorobenzyl trimethylsilyl derivatives: Naming the Murphy rearrangement Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1267():124794 Übersicht Tsikas,Dimitrios ; Analysis, biology and significance of dimethylamine, trimethylamine and trimethylamine N-oxide in humans and in the marine ecosystem, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1258():124602 Originalpublikation Tsikas,Dimitrios ; Assessment of matrix effects in quantitative GC-MS by using isotopologs, United States,Anal.Biochem.,2025;705():115928 Originalpublikation Tsikas,Dimitrios ; Interpretation of negative-ion chemical ionization GC-MS and GC-MS/MS mass spectra of perfluorinated organic analyte derivatives: Consideration of reduction reactions in the gas phase, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1253():124487 Originalpublikation Tsikas,Dimitrios ; Pentafluorobenzyl bromide - A versatile derivatization agent in chromatography and mass spectrometry: II. Analysis of organic acids and bases, and comparison with other perfluorinated reagents, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1257():124578 Originalpublikation Tsikas,Dimitrios ; Proposal and application of nitrogen rules in interpreting gas chromatography negative-ion chemical ionization mass spectrometry spectra, United States,Anal.Biochem.,2025;705():115922 Originalpublikation Tsikas,Dimitrios ; Quantitative Gas Chromatography-Mass Spectrometry in the Life Sciences Principles and Bioanalytical Applications. In: . . Chantilly: , 2025, 735 Seiten- , Buchbeitrag, Monografie Tsikas,Dimitrios ; Quantitative GC-MS/MS in the clinical analysis of eicosanoids: A critical review and discussion, a 40-years historical retrospect, and possible implications for LC-MS/MS, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1270():124911 Originalpublikation Tsikas,Dimitrios ; Quantitative GC-NICI-MS and GC-NICI-MS/MS analysis by using isotopologs as internal standards: A tutorial review, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2025;1262():124648 Originalpublikation Tsikas,Dimitrios ; Underlying Mechanisms of Chromatographic H/D, H/F, cis/trans and Isomerism Effects in GC-MS, Switzerland,,2025;15(1):43- Originalpublikation Tsikas,Dimitrios ; A McLafferty-Type Rearrangement in the Pentafluorobenzyl Ester Derivatives of Dialkyl Phosphates in GC-NICI-MS/MS: A Mini-Review and a Meta-Analysis Molecules, 2025, 31(1), 22- , Originalpublikation Tsikas,Dimitrios S . ; Tsikas,Stefanos A. ; Collision-Induced Gas-Phase Reactions of PFB-TMS Derivatives of F(2)-Prostaglandins in Quadrupole GC-NICI-MS/MS: A Mini-Review and a Meta-Analysis, Switzerland,Molecules,2025;30(19):3846- Originalpublikation Ückert,Stefan ; Hedlund,Petter ; Tsikas,Dimitrios ; Kuczyk,Markus A. ; The significance of endocannabinoid receptors and endocannabinoids in the lower urinary and genital tract, Germany,World J.Urol.,2025;44(1):26 Originalpublikation Wolter,Sabine ; Neumann,Martin ; Koenig,Theresa ; Hagedorn,Tina ; Schwede,Frank ; Pich,Andreas ; Seifert,Roland Identification of cCMP- and cUMP-binding proteins using cCMP and cUMP coupled to agarose and biotin matrices, United States,PLoS One,2025;20(10):e0333904- Originalpublikation 2024 Abbas,Naisam ; Bentele,Marco ; Waleczek,Florian J. G. ; Fuchs,Maximilian ; Just,Annette ; Pfanne,Angelika ; Pich,Andreas ; Linke,Sophie ; Neumüller,Susanne ; Stucki-Koch,Angelika ; Jordan,Maria ; Perbellini,Filippo ; Werlein,Christopher ; Korte,Wilhelm ; Ius,Fabio ; Ruhparwar,Arjang ; Weber,Natalie ; Fiedler,Jan ; Thum,Thomas ; Ex vivo modelling of cardiac injury identifies ferroptosis-related pathways as a potential therapeutic avenue for translational medicine J.Mol.Cell.Cardiol., 2024, 196(), 125- 140, Originalpublikation Abbas,Naisam ; Haas,Jonas A. ; Xiao,Ke ; Fuchs,Maximilian ; Just,Annette ; Pich,Andreas ; Perbellini,Filippo ; Werlein,Christopher ; Ius,Fabio ; Ruhparwar,Arjang ; Fiedler,Jan ; Weber,Natalie ; Thum,Thomas ; Inhibition of miR-21: cardioprotective effects in human failing myocardium ex vivo Eur.Heart J., 2024, 45(22), 2016- 2018, Originalpublikation Albers,Marco Darius ; Tiemann,Birgit ; Kaynert,Jonas Till ; Pich,Andreas ; Bakker, Hans ; Konservierte Cysteine verhindern die C-Mannosylierung von Mucin-Cys-Domänen, England, FEBS J., 2024; 291(15):3539-3552 Originalpublikation Baskal,Svetlana ; Posma, Rene A. ; Bollenbach, Alexander ; Dieperink, Willem ; Bakker, Stephan J. L. ; Nijsten, Maarten W. ; Touw, Daan J. ; Tsikas, Dimitrios ; GC-MS-Analyse von 4-Hydroxyprolin: erhöhte Prolinhydroxylierung bei Patienten mit Metformin-assoziierter Laktatazidose und mit Metformin behandelten Patienten mit Becker-Muskeldystrophie, Österreich, Aminosäuren, 2024; 56(1):21- Originalpublikation Dimina,Laurianne Jolata ; Leray,Vincent ; Voute,Marion ; David,Jérémie ; Blavignac,Christelle ; Farges,Marie-Chantal ; Rossary,Adrien ; Tsikas,Dimitrios ; Rémond,Didier ; Pickering,Gisèle ; Mariotti,François ; Dietary Protein in a Challenge Meal Does Not Alleviate Postprandial Impairments in Vascular Endothelial Function in Healthy Older Adults with Cardiometabolic Risk: A Randomized Crossover-Controlled Trial J.Nutr., 2024, 154(12), 3664- 3680, Originalpublikation Hedlund,Petter ; Rahardjo,Harrina E. ; Tsikas,Dimitrios ; Kuczyk,Markus A. ; Ückert,Stefan ; Drugs to affect the smooth musculature of the human ureter - an update with integrated information from basic science to the use in medical expulsion therapy (MET) World J.Urol., 2024, 42(1), 654- , Originalpublikation Hirsch,Merle S. ; Hildebrand, Christina B. ; Geltinger,Florian ; Pich,Andreas ; Mühlfeld,Christian ; Wedekind, Dirk ; Brandenberger, Christina ; Seneszenz in alveolären epithelialen Typ-II-Zellen fördert akute Lungenschäden und beeinträchtigt die Regeneration,Vereinigte Staaten,Am.J.Respir.Cell Mol.Biol.,2024; ():- Originalpublikation Hose, Leonie; Langenhagen, Alina Katharina; Kefalakes, Ekaterini; Schweitzer, Theresa ; Kubinski, Sabrina; Barak, Segev; Pich, Andreas ; Grothe, Claudia A dual-omics approach on the effects of fibroblast growth factor-2 (FGF-2) on ventral tegmental area dopaminergic neurons in response to alcohol consumption in mice. PMID: 38185886 Originalpublikation Khan,Bushra ; Lanzuolo,Chiara ; Rosti,Valentina ; Santarelli,Philina ; Pich,Andreas ; Kraft,Theresia ; Amrute-Nayak,Mamta ; Nayak,Arnab ; Sorafenib induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes, United States,,2024;27(10):110913 Originalpublikation Klawitter,Jost ; Weissenborn,Wiebke ; Gvon,Iuliia ; Walz,Mackenzie ; Klawitter,Jelena ; Jackson,Matthew ; Sempio,Cristina ; Joksimovic,Sonja L. ; Shokati,Touraj ; Just,Ingo ; Christians,Uwe ; Todorovic,Slobodan M. ; β-Caryophyllene Inhibits Monoacylglycerol Lipase Activity and Increases 2-Arachidonoyl Glycerol Levels In Vivo: A New Mechanism of Endocannabinoid-Mediated Analgesia? Mol.Pharmacol., 2024, 105(2), 75- 83, Originalpublikation Krueger,Jonas ; Preusse,Matthias ; Oswaldo Gomez,Nicolas ; Frommeyer,Yannick Noah ; Doberenz,Sebastian ; Lorenz,Anne ; Kordes,Adrian ; Grobe,Svenja ; Müsken,Mathias; Depledge,Daniel P. ; Svensson,Sarah L. ; Weiss,Siegfried ; Kaever,Volkhard ; Pich,Andreas ; Sharma,Cynthia M. ; Ignatova,Zoya ; Häussler,Susanne ; tRNA epitranscriptome determines pathogenicity of the opportunistic pathogen Pseudomonas aeruginosa, United States,Proc.Natl.Acad.Sci.U.S.A.,2024;121(11):-e2312874121 Originalpublikation Kukoc-Modun, Lea; Kraljevic, Tomislav; Tsikas, Dimitrios ; Spassov, Tony G; Kolev, Spas D Determination of -Acetyl-L-cysteine Ethyl Ester (NACET) by Sequential Injection Analysis. PMID: 38257405 Originalpublikation Neufeldt,Dimyana ; Schmidt,Arne ; Mohr,Elisa ; Lu,Dongchao; Chatterjee,Shambhabi ; Fuchs,Maximilian; Xiao,Ke ; Pan,Wen; Cushman,Sarah; Jahn,Christopher; Juchem,Malte; Hunkler,Hannah Jill ; Cipriano,Giuseppe ; Jürgens,Bjarne ; Schmidt,Kevin ; Groß,Sonja ; Jung,Mira ; Hoepfner,Jeannine ; Weber,Natalie ; Foo,Roger ; Pich,Andreas ; Zweigerdt,Robert ; Kraft,Theresia ; Thum,Thomas ; Bär,Christian ; Circular RNA circZFPM2 regulates cardiomyocyte hypertrophy and survival, Germany,Basic Res.Cardiol.,2024;119(4):613-632 Originalpublikation Oms,Elisabeth ; Untersuchung des RGD-Motivs in der Bindung und Aufnahme von C3bot in HT22 Zellen, Hannover,,2024;():-4 ungezählte Blätter, 98 Blätter : Dissertation Posma,Rene A. ; Bakker,Stephan J. L. ; Nijsten,Maarten W. ; Touw,Daan J. ; Tsikas,Dimitrios ; Comprehensive GC-MS Measurement of Amino Acids, Metabolites, and Malondialdehyde in Metformin-Associated Lactic Acidosis at Admission and during Renal Replacement Treatment, Switzerland,J.Clin.Med.,2024;13(13):3692- Originalpublikation Post,Adrian ; Groothof,Dion ; Kremer,Daan ; Knobbe,Tim J. ; Abma,Willem ; Koops,Christa A. ; Tsikas,Dimitrios ; Wallimann,Theo ; Dullaart,Robin P. F. ; Franssen,Casper F. M. ; Kema,Ido P. ; Heiner-Fokkema,M. Rebecca ; Bakker,Stephan J. L. ; Creatine homeostasis and the kidney: comparison between kidney transplant recipients and healthy controls, Austria,Amino Acids,2024;56(1):42- Originalpublikation Przykopanski,Adina ; Untersuchung der Komplexbildung des proteinogenen Botulinum Neurotoxins mit dessen assoziierten Proteinen und deren Einfluss auf den transepithelialen Transport des Toxins 2023, Dissertation Sainz von Petzinger,Sylvana ; Protektive Effekte von Chitosan Oligosacchariden gegen Clostridioides difficile Toxin A und Toxin B 2024, Masterarbeit Schmidt,Kevin ; Schmidt,Arne ; Groß,Sonja ; Just,Annette ; Pfanne,Angelika ; Fuchs,Maximilian ; Jordan,Maria ; Mohr,Elisa ; Pich,Andreas ; Fiedler,Jan ; Thum,Thomas ; SGLT2 inhibitors attenuate endothelial to mesenchymal transition and cardiac fibroblast activation, England,Sci.Rep.,2024;14(1):16459- Originalpublikation Scholz,Jonas ; Stephan,Till ; Pérez,Aina Gallemí ; Csiszár,Agnes ; Hersch,Nils ; Fischer,Lisa S. ; Brühmann,Stefan ; Körber,Sarah ; Litschko,Christof ; Mijanovic,Lucija ; Kaufmann,Thomas ; Lange,Felix ; Springer,Ronald ; Pich,Andreas ; Jakobs,Stefan ; Peckham,Michelle ; Tarantola,Marco ; Grashoff,Carsten ; Merkel,Rudolf ; Faix,Jan ; Decisive role of mDia-family formins in cell cortex function of highly adherent cells Sci.Adv., 2024, 10(44), - eadp5929, Originalpublikation Tapken,Ines ; Schweitzer,Theresa ; Paganin,Martina ; Schüning,Tobias ; Detering,Nora T. ; Sharma,Gaurav ; Niesert,Moritz ; Saffari,Afshin ; Kuhn,Daniela ; Glynn,Amy ; Cieri,Federica ; Santonicola,Pamela ; Cannet,Claire ; Gerstner,Florian ; Faller,Kiterie M. E. ; Huang,Yu-Ting ; Kothary,Rashmi ; Gillingwater,Thomas H. ; Di Schiavi,Elia ; Simon,Christian M. ; Hensel,Niko ; Ziegler,Andreas ; Viero,Gabriella ; Pich,Andreas ; Claus,Peter ; The systemic complexity of a monogenic disease: the molecular network of spinal muscular atrophy Brain, 2024, (), - , Originalpublikation Tsap,Mariana I. ; Yatsenko,Andriy S. ; Hegermann,Jan ; Beckmann,Bibiana ; Tsikas,Dimitros ; Shcherbata,Halyna R. ; Unraveling the link between Neuropathy Target Esterase NTE/SWS, lysosomal storage diseases, inflammation, abnormal fatty acid metabolism, and leaky brain barrier, England,Elife,2024;13():-e98020 Originalpublikation Tsikas, Dimitrios Application of the Bland-Altman and Receiver Operating Characteristic (ROC) Approaches to Study Isotope Effects in Gas Chromatography-Mass Spectrometry Analysis of Human Plasma, Serum and Urine Samples Molecules, 29(2):365, 2024 ISSN:1420-3049 (elektronisch)PMID:38257277 »DOI:10.3390/molecules29020365 » Originalpublikation Tsikas,Dimitrios ; Perspektiven der quantitativen GC-MS, LC-MS und ICP-MS in der klinischen Medizin - Die Rolle der analytischen Chemie, Schweiz, J.Clin.Med., 2024; 13(23):7276 Originalpublikation Tsikas,Dimitrios ; Zugrunde liegende Mechanismen von chromatographischen H/D-, H/F-, cis/trans- und Isomerie-Effekten bei GC-MS, Schweiz, 2025; 15(1):43 Originalpublikation Waleczek,Florian J. G. ; Cipriano,Giuseppe ; Haas,Jonas A. ; Garg,Ankita ; Pfanne,Angelika ; Just,Annette ; Neumüller,Susanne ; Hegermann,Jan ; Pich,Andreas ; Radocaj,Ante ; Xiao,Ke ; Weber,Natalie ; Thum,Thomas ; Prolonged Hypoxia in Rat Living Myocardial Slices Affects Function, Expression, and Structure Int.J.Mol.Sci., 2024, 26(1), 218- , Originalpublikation Wu,Xuekun ; Zheng,Linqun ; Reboll,Marc R. ; Hyde,Lillian F. ; Mass,Elvira ; Niessen,Hans W. ; Kosanke,Maike ; Pich,Andreas ; Giannitsis,Evangelos ; Tillmanns,Jochen ; Bauersachs,Johann ; Heineke,Joerg ; Wang,Yong ; Korf-Klingebiel,Mortimer ; Polten,Felix ; Wollert,Kai C. ; Cysteine-rich with EGF-like domains 2 (CRELD2) is an endoplasmic reticulum stress-inducible angiogenic growth factor promoting ischemic heart repair, England,Nat.Cardiovasc.Res.,2024;3(2):186-202 Originalpublikation Zobl,Walter ; Integration of in vitro methods into regulatory hazard assessment: two proof-of-concept case studies, Hannover,,2024;():IX, 20, 17 Blätter, Blatt 38, 14 Blätter-77 : Illustrationen, Diagramme Dissertation 2023 Bousnaki,Maria; Bakopoulou,Athina; Grivas,Ioannis; Bekiari,Chrysa; Pich,Andreas ; Rizk,Marta; Keklikoglou,Kleoniki; Papachristou,Eleni; Papadopoulos,Georgios C.; Kritis,Aristeidis; Mikos,Antonios G.; Koidis,Petros; Behandlung von Kiefergelenksarthrose durch dentales Stammzellsekretom, Vereinigte Staaten,Stammzell.Rev.Rep.,2023; 19(8):2957-2979 Originalpublikation Deppe,Julian ; Untersuchung der Funktion der HCN-Domäne clostridieller Neurotoxine, Hannover,,2022; ():V, 15, 22 Blätter, Blatt VI-XXII : Illustrationen, Diagramme Dissertation Eggenkemper,Lisa; Schlegtendal,Anne; Maier,Christoph; Lücke,Thomas; Brinkmann,Folke; Beckmann,Bibiana ; Tsikas,Dimitrios ; Koerner-Rettberg,Cordula; Beeinträchtigte Stickstoffmonoxid-Synthetase-Aktivität bei primärer ziliärer Dyskinesie-datengesteuerter Hypothese, Schweiz,J.Clin.Med.,2023; 12(18):6010 Originalpublikation Emons,Barbara; Arning,Larissa; Makulla,Vera-Estelle; Suchy,Maria-Theresia; Tsikas,Dimitrios ; Lücke,Thomas; Epplen,Jörg T.; Juckel,Georg; Roser,Patrik; Endocannabinerge Modulation der zentralen serotonergen Aktivität bei gesunden menschlichen Freiwilligen, England,Ann.Gen.Psychiatry.,2023; 22(1):11 Originalpublikation Gao,Linfeng; Lam,Kwok-Ho; Liu,Shun; Przykopanski,Adina ; Lübke,Johanna; Qi,Ruifeng; Krüger,Maren; Nowakowska,Maria B.; Selby,Katja; Douillard,François P.; Dorner,Martin B.; Perry,Kay; Lindström,Miia; Dorner,Brigitte G.; Rummel,Andreas ; Jin,Rongsheng; Kristallstrukturen von OrfX1, OrfX2 und dem OrfX1-OrfX3-Komplex aus dem orfX-Gencluster des Botulinum-Neurotoxins E1, England, FEBS Lett.,2023;597(4):524-537 10.1002/1873-3468.14576, Originalpublikation Haukamp,Funmilola Josephine; Hartmann,Zoe Maria; Pich,Andreas ; Kuhn,Joachim; Blasczyk,Rainer; Stieglitz,Florian ; Bade-Döding,Christina; HLA-B*57:01/Carbamazepin-10,11-Epoxid-Assoziation löst Hochregulierung der NFkappaB- und JAK/STAT-Signalwege aus, Schweiz,Cells,2023;12(5):676-10.3390 /cells12050676 Berichtsjahr:2023 | ID: RefID:26161-haukamp2023hla-b*57:01/carbamazepine-1 Originalpublikation Heils,Lucas; Schneemann,Martina; Gerhard,Ralf ; Schulzke,Jörg-Dieter; Bücker,Roland; CDT von Clostridioides difficile induziert MLC-abhängige intestinale Barrieredysfunktion in HT-29/B6-Epithelzellmonoschichten, Schweiz,Toxine (Basel),2023;15(1):54-10.3390 /toxins15010054, Berichtsjahr:2023 | ID: RefID:26111-heils2023cdt Originalpublikation Hildebrand,Christina B.; Lichatz,Rita; Pich,Andreas ; Mühlfeld,Christian; Woltemate,Sabrina; Vital,Marius; Brandenberger,Christina; Kurzkettige Fettsäuren verbessern die Alterung und akute Lungenschädigung bei alten Mäusen, Vereinigte Staaten,Am.J.Physiol.Lung Cell.Mol.Physiol.,2023;():- 10.1152/ajplung.00296.2022 Berichtsjahr:2023 | ID: RefID:26113-hildebrand2023short Originalpublikation Hollwedel, Femke D; Maus, Regina; Stolper, Jennifer; Iwai, Satoru; Kasai, Hayato; Holtfreter, Silva; Pich, Andreas ; Neubert, Lavinia; Welte, Tobias; Yamasaki, Sho; Maus, Ulrich A Ectopic expression of C-type lectin Mincle renders mice susceptible to staphylococcal pneumonia. PMID: 38159068 Originalpublikation Joensuu,Merja; Syed,Parnayan; Saber,Saber H.; Lanoue,Vanessa; Wallis,Tristan P.; Rae,James; Blum,Ailisa; Gormal,Rachel S.; Small,Christopher; Sanders,Shanley; Jiang,Anmin; Mahrhold,Stefan ; Krez,Nadja; Cousin,Michael A.; Cooper-White,Ruby; Cooper-White,Justin J.; Collins,Brett M.; Parton,Robert G.; Balistreri,Giuseppe; Rummel,Andreas ; Meunier,Frederic A.; Presynaptic targeting of botulinum neurotoxin type A requires a tripartite PSG-Syt1-SV2 plasma membrane nanocluster for synaptic vesicle entry, England,EMBO J.,2023;42(13):-e112095 10.15252/embj.2022112095 Berichtsjahr:2023 | ID: RefID:39384-joensuu2023presynaptic Originalpublikation Liu,Zheng; Lee,Pyung-Gang; Krez,Nadja; Lam,Kwok-Ho; Liu,Hao; Przykopanski,Adina ; Chen,Peng; Yao,Guorui; Zhang,Sicai; Tremblay,Jacqueline M.; Perry,Kay; Shoemaker,Charles B.; Rummel,Andreas ; Dong,Min; Jin,Rongsheng; Structural basis for botulinum neurotoxin E recognition of synaptic vesicle protein 2, England,Nat.Commun.,2023;14(1):2338-10.1038/s41467-023-37860-8 Berichtsjahr:2023 | ID: RefID:26323-liu2023structural Originalpublikation Manion,John; Musser,Melissa A.; Kuziel,Gavin A.; Liu,Min; Schäfer,Amy; Wang,Siyu; Lee,Pyung-Gang; Zhao,Leo; Zhang,Jie; Marreddy,Ravi K. R.; Goldschmied,Jeffrey D.; Yuan,Ke; Hürde,Julian G.; Gerhard,Ralf ; Jin,Rongsheng; Rakoff-Nahoum,Seth; Rao,Meenakshi; Dong,Min; C. difficile vergiftet Neuronen und Perizyten, um neurogene Entzündungen voranzutreiben, England,,2023; 622(7983):611-618 Originalpublikation Baxolele Mhlekude, Dylan Postmus, Saskia Stenzel, January Weiner 3rd, Jenny Jansen, Francisco J Zapatero-Belinchón, Ruth Olmer, Anja Richter, Julian Heinze, Nicolas Heinemann, Barbara Mühlemann, Simon Schroeder, Terry C Jones, Marcel A Müller, Christian Drosten, Andreas Pich , Volker Thiel, Ulrich Martin, Daniela Niemeyer, Gisa Gerold, Dieter Beule, Christine Goffinet Die pharmakologische Hemmung von Bromodomänen und extraterminalen Proteinen induziert einen NRF-2-vermittelten antiviralen Zustand, der durch eine SARS-CoV-2-Infektion untergraben wird, Vereinigte Staaten, PLoS Pathog., 2023; ():- Originalpublikation Mikuteit,Marie; Baskal,Svetlana ; Klawitter,Sandra; Dopfer-Jablonka,Alexandra; Behrens,Georg M. N.; Müller,Frank; Schröder,Dominik; Klawonn,Frank; Steffens,Sandra; Tsikas,Dimitrios ; Aminosäuren, posttranslationale Modifikationen, Stickstoffmonoxid und oxidativer Stress in Serum und Urin von Long-COVID- und Ex-COVID-Probanden, Österreich,Aminosäuren,2023; 55(9):1173-1188 Originalpublikation Pankoke,Sophia; Schweitzer,Theresa ; Biker,Rolf; Pich,Andreas ; Pfarrer,Christiane; Mühlfeld,Christian; Schipke,Julia; Fettleibigkeit wirkt sich auf die Hypoxieanpassung der Lunge aus, Vereinigte Staaten,Am.J.Physiol.Lung Cell.Mol.Physiol.,2023; 325(3):L352-L359 Originalpublikation Pokrant,Thomas; Hein,Jens Ingo; Körber,Sarah; Disanza,Andrea; Pich,Andreas ; Scita,Giorgio; Rottner,Klemens; Faix,Jan; Das Ena/VASP-Clustering an den Mikrospike-Spitzen umfasst Lamellipodin, aber keine I-BAR-Proteine und erfordert unbedingt unkonventionelle Myosin-X, United States,Proc.Natl.Acad.Sci.U.S.A.,2023;120(2):-e2217437120 10.1073/pnas.2217437120 Berichtsjahr:2023 | ID: RefID:26134-pokrant2023ena/vasp Originalpublikation Rahardjo,Harrina E.; Märker,Viktoria; Tsikas,Dimitrios ; Kuczyk,Markus A.; Ückert,Stefan; Bannowsky,Andreas; Fibrotische Erkrankungen der menschlichen Harn- und Genitalwege: aktuelles Verständnis und mögliche Behandlungsstrategien, Schweiz,J.Clin.Med.,2023; 12(14):4770 Originalpublikation Rahardjo,Harrina E. ; Ückert,Stefan ; Tsikas,Dimitrios ; Bannowsky,Andreas ; Kuczyk,Markus A. ; Becker,Armin J. ; Courses of Arginine-Vasopressin in the Systemic and Cavernous Blood through Different Stages of Sexual Arousal in Healthy Males and Patients with Erectile Dysfunction,,,2023;2023():7978734- Originalpublikation Rohrbeck,Astrid ; Bruhn,Vanessa Anna ; Hussein,Nali ; Hagemann,Sandra ; Just,Ingo ; Clostridium botulinum C3bot vermittelte Wirkungen auf den Zytokin-induzierten Psoriasis-ähnlichen Phänotyp im Hautmodell mit voller Dicke, Deutschland,Naunyn Schmiedebergs Arch.Pharmacol.,2023; ():- Originalpublikation Rosenstein,Christopher ; Identifizierung einer zweiten Rezeptorbindungstasche in Botulinum Neurotoxin F, Hannover,,2022;():-2 ungezählte Blätter, 77 Blätter : 10.26068/mhhrpm/20230601-002 Berichtsjahr:2023 | ID: RefID:26365-rosenstein2022identifizierung Dissertation Schneemann,Martina; Heils,Lucas; Moos,Verena; Weiß,Franziska; Krug,Susanne M.; Weiner,Januar; Beule,Dieter; Gerhard,Ralf ; Schulzke,Jörg-Dieter; Bücker,Roland; Ein Kolon-Organoid-Modell, das mit den großen Toxinen von Clostridioides difficile TcdA und TcdB konfrontiert ist, weist deregulierte Tight-Junction-Proteine auf, Schweiz,Toxins (Basel),2023; 15(11):643 Originalpublikation Schweitzer,Theresa ; Untersuchungen zu den Wirkungen clostridieller glukosylierender Toxine,Hannover,,2023; ():-VIII, 115 Seiten : Illustrationen, Diagramme Dissertation Sinningen,Kathrin; Emons,Barbara; Böhme,Pierre; Juckel,Georg; Hanusch,Beatrice; Beckmann,Bibiana ; Tsikas,Dimitrios ; Lücke,Thomas; L-Arginin/Stickstoffmonoxid-Signalweg und oxidativer Stress bei Erwachsenen mit ADHS: Auswirkungen der Methylphenidat-Behandlung, Vereinigte Staaten, Stickstoffmonoxid, 2023; 138-139():64-69 Originalpublikation Tsikas,Dimitrios ; Acetazolamid und menschliche Carboanhydrasen: Rückblick, Rückblick und Diskussion einer intimen Beziehung, England,J.Enzyme Inhib.Med.Chem.,2024; 39(1):2291336 sonstiges Tsikas,Dimitrios ; Beckmann,Bibiana ; Baskal,Svetlana ; Brunner,Görig ; Pentafluorpropionsäure-Anhydrid-Derivatisierung und GC-MS-Analyse von Histamin, Agmatin, Putrescin und Spermidin: Auswirkungen von Lösungsmitteln und Startsäulentemperatur, Schweiz,Moleküle,2023; 28(3):939 Originalpublikation Tsikas,Dimitrios ; Beckmann,Bibiana ; Qualitätskontrolle in gezielter GC-MS für Aminosäure-OMICS, Schweiz,,2023; 13(9):986 Originalpublikation Tsikas,Dimitrios ; Büttner,Petra; Sagen zirkulierende Konzentrationen von L-Arginin-Metaboliten den Status der koronaren Herzkrankheit und die Wahrscheinlichkeit kardiovaskulärer Ereignisse voraus?, Poland,Pol.Arch.Intern.Med.,2023;133(2):16429-10.20452 /pamw.16429 Berichtsjahr:2023 | ID: RefID:26154-tsikas2023zirkulierend Editorial Tsikas,Dimitrios ; GC-MS- und GC-MS/MS-Messung von Malondialdehyd (MDA) in klinischen Studien: Präanalytische und klinische Überlegungen, Niederlande,J.Mass.Spectrom.Adv.Clin.Lab.,2023; 30():10-24 Übersicht Tsikas,Dimitrios ; GC-MS-Studien zur Stickstoffmonoxid-Autoxidation und S-Nitrosothiol-Hydrolyse zu Nitrit in pH-neutralen wässrigen Puffern: Definitive Ergebnisse unter Verwendung von (15)N- und (18)O-Isotopen, Schweiz,Moleküle,2023; 28(11):4281-http://doi.org/10.3390/molecules28114281 Originalpublikation Tsikas,Dimitrios ; Malondialdehyd-induzierte posttranslationale Modifikation des menschlichen Hämoglobins, Vereinigte Staaten,J.Proteome Res.,2023; 22(6):2141-2143 Kommentar Tsikas,Dimitrios ; Massenspektrometrie-basierte Bewertung des Bland-Altman-Ansatzes: Überprüfung, Diskussion und Vorschlag, Schweiz,Moleküle,2023; 28(13):4905 Übersicht Tsikas,Dimitrios ; Measurement of nitro-oleic acid and nitro-linoleic acid in plasma by GC-MS/MS and LC-MS/MS in health and disease: The significance of the internal standard, Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2023;1221():123684-10.1016/j.jchromb.2023.123684 Berichtsjahr:2023 | ID: RefID:26250-tsikas2023measurement Letter Tsikas,Dimitrios ; Tsikas,Stefanos A.; Mikuteit,Marie; Ückert,Stefan; Zirkulierende und Urinkonzentrationen von Malondialdehyd bei alternden Menschen in Gesundheit und Krankheit: Überprüfung und Diskussion, Schweiz,,2023; 11(10):2744 Übersicht Weißenborn,Wiebke ; Pharmakologische Untersuchungen des Sesquiterpens BCP als potenzielle postoperative Opioidalternative, Hannover,,2022; ():-4 ungezählte Blätter, 78 Blätter Dissertation 2022 Baskal,S. ; Beckmann,B. ; Stahmer,L.; Peter,C.; Bohnhorst,B.; Das,A. 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Innovative and Highly Sensitive Detection of Clostridium perfringens Enterotoxin Based on Receptor Interaction and Monoclonal Antibodies, Switzerland,Toxins (Basel),2021;13(4):266- Originalpublikation Nickel,K. ; Wensorra,U. ; Wenck,H. ; Peters,N. ; Genth,H. Evaluation of Immunomodulatory Responses and Changed Wound Healing in Type 2 Diabetes-A Study Exploiting Dermal Fibroblasts from Diabetic and Non-Diabetic Human Donors, Switzerland,Cells,2021;10(11):2931- Originalpublikation Ostermann,L. ; Maus,R. ; Stolper,J. ; Schütte,L. ; Katsarou,K. ; Tumpara,S. ; Pich,A. ; Mueller,C. ; Janciauskiene,S. ; Welte,T. ; Maus,U. A. Alpha-1 antitrypsin deficiency impairs lung antibacterial immunity in mice, United States,JCI Insight,2021;6(3):- Originalpublikation Post,A. ; Bollenbach,A. ; Bakker,S. J. 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Post-translational modifications (PTM): analytical approaches, signaling, physiology and pathophysiology-part I Austria, Amino Acids,2021;53(4):485-487 Editorial Tsikas,D. ; Comment on the article Structure and mechanism of copper-carbonic anhydrase II: a nitrite reductase, England,IUCrJ,2021;8(Pt 2):327-328 Comment Tsikas,D. ; Extra-platelet low-molecular-mass thiols mediate the inhibitory action of S-nitrosoalbumin on human platelet aggregation via S-transnitrosylation of the platelet surface, Austria, Amino Acids,2021;53(4):563-573 Originalpublikation Tsikas,D. ; GC-MS Analysis of Biological Nitrate and Nitrite Using Pentafluorobenzyl Bromide in Aqueous Acetone: A Dual Role of Carbonate/Bicarbonate as an Enhancer and Inhibitor of Derivatization, Switzerland,Molecules,2021;26(22):7003- Originalpublikation Tsikas,D. ; Homocysteine and copper ions: is their interaction responsible for cardiovascular-related damage? 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A mouse model of cardiogenic shock, England,Cardiovasc.Res.,2021;117(12):2414-2415 Letter Ahmadpour,Jamshid Untersuchung zur Antikörperbildung gegen Botulinum Neurotoxin A im Rahmen der Therapie von Bewegungsstörungen Hannover,,2018;():4 ungezählte Seiten, 76 Seiten : Illustrationen, - Dissertation Schneider,Carmen Intrazelluläre Aktivität der pathogenen Domäne großer clostridialer Glucosyltransferasen Hannover,,2021;():VII, 135 Blätter : Illustrationen, Diagramme- Dissertation Weber,Kathrin GC-MS-basierte Untersuchungen zur Bedeutung der renalen Carboanhydrasen für die Rückresorption von Nitrit und den oxidativen Stress am Menschen Hannover,,2020;():5 ungezählte Blätter, VI Blätter, 102 Blätter - Dissertation Hussein,Nali C3-vermittelte Effekte bei Psoriasis am Phenion 3D-Vollhautmodell, Hannover,,;():78 Seiten- Masterarbeit Langejürgen,Anna Die Rolle der Makropinozytose in der zellulären Aufnahme von C. difficile Toxin Hannover,,;():74 Seiten- Masterarbeit von der Kammer,Urs Darstellung der Interaktion der Botulinum Neurotoxine Serotyp A und E mit ihren Proteinrezeptoren Synaptisches Vesikelglykoprotein C und A, Hannover,,;():106 Seiten- Masterarbeit 2020 Adolf,A. ; Turko,P. ; Rohrbeck,A. ; Just,I. ; Vida,I. ; Ahnert-Hilger,G. ; Höltje,M. The Higher Sensitivity of GABAergic Compared to Glutamatergic Neurons to Growth-Promoting C3bot Treatment Is Mediated by Vimentin Switzerland,Front.Cell.Neurosci.,2020;14():596072- Originalpublikation Alberts,A. ; Klingberg,A. ; Hoffmeister,L. ; Wessig,A. K. ; Brand,K. ; Pich,A. ; Neumann,K. Binding of Macrophage Receptor MARCO, LDL, and LDLR to Disease-Associated Crystalline Structures Switzerland,Front.Immunol.,2020;11():596103- Originalpublikation Alberts,A. ; Klingberg,A. ; Wessig,A. K. ; Combes,C. ; Witte,T. ; Brand,K. ; Pich,A. ; Neumann,K. C-reactive protein (CRP) recognizes uric acid crystals and recruits proteases C1 and MASP1 England,Sci.Rep.,2020;10(1):6391- Originalpublikation Becker,T. ; Pich,A. ; Tamm,S. ; Hedtfeld,S. ; Ibrahim,M. ; Altmüller,J. ; Dalibor,N. ; Toliat,M. R. ; Janciauskiene,S. ; Tümmler,B. ; Stanke,F. Genetic information from discordant sibling pairs points to ESRP2 as a candidate trans-acting regulator of the CF modifier gene SCNN1B England,Sci.Rep.,2020;10(1):22447- Originalpublikation Begou,O. ; Drabert,K. ; Theodoridis,G. ; Tsikas,D. GC-NICI-MS analysis of acetazolamide and other sulfonamide (R-SO2-NH2) drugs as pentafluorobenzyl derivatives [R-SO2-N(PFB)2] and quantification of pharmacological acetazolamide in human urine China,J.Pharm.Anal.,2020;10(1):49-59 Originalpublikation Bollenbach,A. ; Gambaryan,S. ; Mindukshev,I. ; Pich,A. ; Tsikas,D. GC-MS and LC-MS/MS pilot studies on the guanidine (N(G))-dimethylation in native, asymmetrically and symmetrically N(G)-dimethylated arginine-vasopressin peptides and proteins in human red blood cells Netherlands,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2020;1141():122024- Originalpublikation Bollenbach,A. ; Schutte,A. E. ; Kruger,R. ; Tsikas,D. An Ethnic Comparison of Arginine Dimethylation and Cardiometabolic Factors in Healthy Black and White Youth: The ASOS and African-PREDICT Studies Switzerland,J.Clin.Med.,2020;9(3):844.- Originalpublikation Bollenbach,A. ; Tsikas,D. Measurement of the tripeptides glutathione and ophthalmic acid by gas chromatography-mass spectrometry United States,Anal.Biochem.,2020;():- Originalpublikation Brinkmann,F. ; Hanusch,B. ; Ballmann,M. ; Mayorandan,S. ; Bollenbach,A. ; Chobanyan-Jürgens,K. ; Jansen,K. ; Schmidt-Choudhury,A. ; Derichs,N. ; Tsikas,D. ; Lücke,T. Activated L-Arginine/Nitric Oxide Pathway in Pediatric Cystic Fibrosis and Its Association with Pancreatic Insufficiency, Liver Involvement and Nourishment: An Overview and New Results Switzerland,J.Clin.Med.,2020;9(6):E2012 [pii]- Originalpublikation Craig,A. ; M C Mels,C. ; Tsikas,D. ; Boeger,R. H. ; Schwedhelm,E. ; Schutte,A. E. ; Kruger,R. Central systolic blood pressure relates inversely to nitric oxide synthesis in young black adults: the African-PREDICT study England,J.Hum.Hypertens.,2021;35(11):985-993 Originalpublikation Craig,A. ; Mels,C. M. C. ; Schutte,A. E. ; Bollenbach,A. ; Tsikas,D. ; Schwedhelm,E. ; Kruger,R. ; Urinary albumin-to-creatinine ratio is inversely related to nitric oxide synthesis in young black adults: the African-PREDICT study England,Hypertens.Res.,2021;44(1):71-79 Originalpublikation Craig,A. ; Mels,C. M. C. ; Schutte,A. E. ; Tsikas,D. ; Kruger,R. ; Nitric oxide-related markers link inversely to blood pressure in black boys and men: the ASOS and African-PREDICT studies Austria,Amino Acids,2020;52(4):639-648 Originalpublikation Cseko,K. ; Pecsi,D. ; Kajtar,B. ; Hegedus,I. ; Bollenbach,A. ; Tsikas,D. ; Szabo,I. L. ; Szabo,S. ; Helyes,Z. Upregulation of the TRPA1 Ion Channel in the Gastric Mucosa after Iodoacetamide-Induced Gastritis in Rats: A Potential New Therapeutic Target Switzerland,Int.J.Mol.Sci.,2020;21(16):E5591 [pii]- Originalpublikation Deppe,J. ; Weisemann,J. ; Mahrhold,S. ; Rummel,A. The 25 kDa HCN Domain of Clostridial Neurotoxins Is Indispensable for Their Neurotoxicity Switzerland,Toxins (Basel),2020;12(12):- Originalpublikation Hanusch,B. ; Brinkmann,F. ; Mayorandan,S. ; Chobanyan-Jürgens,K. ; Wiemers,A. ; Jansen,K. ; Ballmann,M. ; Schmidt-Choudhury,A. ; Bollenbach,A. ; Derichs,N. ; Tsikas,D. ; Lücke,T. Local and Systemic Alterations of the L-Arginine/Nitric Oxide Pathway in Sputum, Blood, and Urine of Pediatric Cystic Fibrosis Patients and Effects of Antibiotic Treatment Switzerland,J.Clin.Med.,2020;9(12)::E3802- Originalpublikation Henkel,D. ; Tatge,H. ; Schöttelndreier,D. ; Tao,L. ; Dong,M. ; Gerhard,R. Receptor Binding Domains of TcdB from Clostridioides difficile for Chondroitin Sulfate Proteoglycan-4 and Frizzled Proteins Are Functionally Independent and Additive Switzerland,Toxins (Basel),2020;12(12):- Originalpublikation Hensel,N. ; Raker,V. ; Förthmann,B. ; Buch,A. ; Sodeik,B. ; Pich,A. ; Claus,P. The Proteome and Secretome of Cortical Brain Cells Infected With Herpes Simplex Virus Switzerland,Front.Neurol.,2020;11():844- Originalpublikation Herkt,M. ; Foinquinos,A. ; Batkai,S. ; Thum,T. ; Pich,A. Pharmacokinetic Studies of Antisense Oligonucleotides Using MALDI-TOF Mass Spectrometry Switzerland,Front.Pharmacol.,2020;11():220- Originalpublikation Ho,G. T. ; Hiemisch,W. ; Pich,A. ; Behrens,G. M. N. ; Blasczyk,R. ; Bade-Doeding,C. The Loss of HLA-F/KIR3DS1 Ligation Is Mediated by Hemoglobin Peptides Switzerland,Int.J.Mol.Sci.,2020;21(21):8012- Originalpublikation Hobuss,L. ; Foinquinos,A. ; Jung,M. ; Kenneweg,F. ; Xiao,K. ; Wang,Y. ; Zimmer,K. ; Remke,J. ; Just,A. ; Nowak,J. ; Schmidt,A. ; Pich,A. ; Mazlan,S. ; Reamon-Buettner,S. M. ; Ramos,G. C. ; Frantz,S. ; Viereck,J. ; Loyer,X. ; Boulanger,C. ; Wollert,K. C. ; Fiedler,J. ; Thum,T. Pleiotropic cardiac functions controlled by ischemia-induced lncRNA H19 England,J.Mol.Cell.Cardiol.,2020;146():43-59 Originalpublikation Hollwedel,F. D. ; Maus,R. ; Stolper,J. ; Khan,A. ; Stocker,B. L. ; Timmer,M. S. M. ; Lu,X. ; Pich,A. ; Welte,T. ; Yamasaki,S. ; Maus,U. A. Overexpression of Macrophage-Inducible C-Type Lectin Mincle Aggravates Proinflammatory Responses to Streptococcus pneumoniae with Fatal Outcome in Mice United States,J.Immunol.,2020;205(12):3390-3399 Originalpublikation Jansen,K. ; Hanusch,B. ; Pross,S. ; Hanff,E. ; Drabert,K. ; Bollenbach,A. ; Dugave,I. ; Carmann,C. ; Siefen,R. G. ; Emons,B. ; Juckel,G. ; Legenbauer,T. ; Tsikas,D. ; Lücke,T. Enhanced Nitric Oxide (NO) and Decreased ADMA Synthesis in Pediatric ADHD and Selective Potentiation of NO Synthesis by Methylphenidate Switzerland,J.Clin.Med.,2020;9(1):pii: E175- Originalpublikation Jansing,J. C. ; Fiedler,J. ; Pich,A. ; Viereck,J. ; Thum,T. ; Mühlfeld,C. ; Brandenberger,C. miR-21-KO Alleviates Alveolar Structural Remodeling and Inflammatory Signaling in Acute Lung Injury Switzerland,Int.J.Mol.Sci.,2020;21(3):E822- Originalpublikation Kedia,G. T. ; Ückert,S. ; Tsikas,D. ; Becker,A. J. ; Kuczyk,M. A. ; Bannowsky,A. The Use of Vasoactive Drugs in the Treatment of Male Erectile Dysfunction: Current Concepts Switzerland,J.Clin.Med.,2020;9(9):E2987- Übersicht Kropp,K. A. ; Srivaratharajan,S. ; Ritter,B. ; Yu,P. ; Krooss,S. ; Polten,F. ; Pich,A. ; Alcami,A. ; Viejo-Borbolla,A. Identification of the Cleavage Domain within Glycoprotein G of Herpes Simplex Virus Type 2 Switzerland,Viruses,2020;12(12):E1428 [pii]- Originalpublikation Melzer,C. ; Jacobs,R. ; Dittmar,T. ; Pich,A. ; von der Ohe,J. ; Yang,Y. ; Hass,R. Reversible Growth-Arrest of a Spontaneously-Derived Human MSC-Like Cell Line Switzerland,Int.J.Mol.Sci.,2020;21(13):E4752.- Originalpublikation Neu,A. ; Hornig,S. ; Sasani,A. ; Isbrandt,D. ; Gerloff,C. ; Tsikas,D. ; Schwedhelm,E. ; Choe,C. U. Creatine, guanidinoacetate and homoarginine in statin-induced myopathy Austria,Amino Acids,2020;52(6-7):1067-1069 Letter Schöttelndreier,D. ; Langejürgen,A. ; Lindner,R. ; Genth,H. Low Density Lipoprotein Receptor-Related Protein-1 (LRP1) Is Involved in the Uptake of Clostridioides difficile Toxin A and Serves as an Internalizing Receptor Switzerland,Front.Cell.Infect.Microbiol.,2020;10():565465- Originalpublikation Stojanovic,S. D. ; Fuchs,M. ; Fiedler,J. ; Xiao,K. ; Meinecke,A. ; Just,A. ; Pich,A. ; Thum,T. ; Kunz,M. Comprehensive Bioinformatics Identifies Key microRNA Players in ATG7-Deficient Lung Fibroblasts Switzerland,Int.J.Mol.Sci.,2020;21(11):- Originalpublikation Stojanovic,S. D. ; Fuchs,M. ; Kunz,M. ; Xiao,K. ; Just,A. ; Pich,A. ; Bauersachs,J. ; Fiedler,J. ; Sedding,D. ; Thum,T. Inflammatory Drivers of Cardiovascular Disease: Molecular Characterization of Senescent Coronary Vascular Smooth Muscle Cells Switzerland,Front.Physiol.,2020;11():520- Originalpublikation Tian,S. ; Liu,Y. ; Wu,H. ; Liu,H. ; Zeng,J. ; Choi,M. Y. ; Chen,H. ; Gerhard,R. ; Dong,M. Genome-Wide CRISPR Screen Identifies Semaphorin 6A and 6B as Receptors for Paeniclostridium sordellii Toxin TcsL United States,Cell.Host Microbe,2020;27(5):782-792.e7 Originalpublikation Tsikas,D. GC-MS approach revealing hidden nitrite reactions in hemolysate using (18)O-labelled nitrite and cysteine-based thiols United States,Anal.Biochem.,2020;():114025- Originalpublikation Tsikas,D. Rat liver glutathione S-transferase-catalyzed conjugation of glutathione to the endogenous epoxides of oleic acid and cholesterol United States,Anal.Biochem.,2020;():113994- Originalpublikation Tsikas,D. Urinary Dimethylamine (DMA) and Its Precursor Asymmetric Dimethylarginine (ADMA) in Clinical Medicine, in the Context of Nitric Oxide (NO) and Beyond Switzerland,J.Clin.Med.,2020;9(6):- Übersicht Tsikas,D. ; Surdacki,A. Biotransformation of organic nitrates by glutathione S-transferases and other enzymes: An appraisal of the pioneering work by William B. 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Proteomics 2017; 17(9):1700016- Originalpublikation Volltext Kayacelebi A A, Minovic I, Hanff E, Frenay A S, de Borst M H, Feelisch M, van Goor H, Bakker S J L, Tsikas D Low plasma homoarginine concentration is associated with high rates of all-cause mortality in renal transplant recipients. Amino Acids 2017; 49(7):1193-1202 Originalpublikation Volltext Konze S A, Cajic S, Oberbeck A, Hennig R, Pich A, Rapp E, Buettner F F R Quantitative Assessment of Sialo-Glycoproteins and N-Glycans during Cardiomyogenic Differentiation of Human Induced Pluripotent Stem Cells. Chembiochem 2017; 18(13):1317-1331 Originalpublikation Volltext Konze S A, Werneburg S, Oberbeck A, Olmer R, Kempf H, Jara-Avaca M, Pich A, Zweigerdt R, Buettner F F Proteomic Analysis of Human Pluripotent Stem Cell Cardiomyogenesis Revealed Altered Expression of Metabolic Enzymes and PDLIM5 Isoforms. J. Proteome Res. 2017; 16(3):1133-1149 Originalpublikation Volltext Kukoc-Modun L, Tsikas D, Kraljevi T, Biocic M, Radi N Kinetic Spectrophotometric Determination of N-Acetyl-L-cysteine Ethyl Ester (NACET) Generating Chromogenic Copper(I)Ln Complexes with Different Ligands. Croat. Chem. Acta 2017; 90(2):263-271 Originalpublikation Volltext Lam K H, Qi R, Liu S, Kroh A, Yao G, Perry K, Rummel A, Jin R The hypothetical protein P47 of Clostridium botulinum E1 strain Beluga has a structural topology similar to bactericidal/permeability-increasing protein. Toxicon 2017; DOI: 10.1016/j.toxicon.2017.10.012- Originalpublikation Volltext Nkuipou-Kenfack E, Schanstra J P, Bajwa S, Pejchinovski M, Vinel C, Dray C, Valet P, Bascands J L, Vlahou A, Koeck T, Borries M, Busch H, Bechtel-Walz W, Huber T B, Rudolph K L, Pich A, Mischak H, Zürbig P The use of urinary proteomics in the assessment of suitability of mouse models for ageing. PLoS One 2017; 12(2):e0166875- Originalpublikation Volltext Peck M W, Smith T J, Anniballi F, Austin J W, Bano L, Bradshaw M, Cuervo P, Cheng L W, Derman Y, Dorner B G, Fisher A, Hill K K, Kalb S R, Korkeala H, Lindström M, Lista F, Luquez C, Mazuet C, Pirazzini M, Popoff M R, Rossetto O, Rummel A, Sesardic D, Singh B R, Stringer S C Historical Perspectives and Guidelines for Botulinum Neurotoxin Subtype Nomenclature. Toxins (Basel) 2017; 9(1):DOI: 10.3390/toxins9010038- Übersicht Volltext Reboll M R, Korf-Klingebiel M, Klede S, Polten F, Brinkmann E, Reimann I, Schonfeld H J, Bobadilla M, Faix J, Kensah G, Gruh I, Klintschar M, Gaestel M, Niessen H W, Pich A, Bauersachs J, Gogos J A, Wang Y, Wollert K C EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction. Circulation 2017; 136(19):1809-1823 Originalpublikation Volltext Rohrbeck A, Höltje M, Adolf A, Oms E, Hagemann S, Ahnert-Hilger G, Just I The Rho ADP-ribosylating C3 exoenzyme binds cells via an Arg-Gly-Asp motif. J. Biol. Chem. 2017; 292(43):17668-17680 Originalpublikation Volltext Ruhe F, Olling A, Abromeit R, Rataj D, Grieschat M, Zeug A, Gerhard R, Alekov A Overexpression of the Endosomal Anion/Proton Exchanger ClC-5 Increases Cell Susceptibility toward Clostridium difficile Toxins TcdA and TcdB. Front. Cell. Infect. Microbiol. 2017; 7(67- Originalpublikation Volltext Rummel A Two Feet on the Membrane: Uptake of Clostridial Neurotoxins. Curr.Top.Microbiol.Immunol. 2016; DOI: 10.1007/82_2016_48- Übersicht Volltext Schulze J, Kaiser O, Paasche G, Lamm H, Pich A, Hoffmann A, Lenarz T, Warnecke A Effect of hyperbaric oxygen on BDNF-release and neuroprotection: Investigations with human mesenchymal stem cells and genetically modified NIH3T3 fibroblasts as putative cell therapeutics. PLoS One 2017; 12(5):e0178182- Originalpublikation Volltext Tsikas D Combating atherosclerosis with heavy PUFAs: Deuteron not proton is the first. Atherosclerosis 2017; 264:79-82 Editorial Volltext Tsikas D The dilemma of oxidative stress personified by the disprosopus 8-iso-prostaglandin F2a and prostaglandin F2a. J Controversies Biomed Res 2017; 3(1):11-15 Originalpublikation Volltext Tsikas D Does oxidative stress change during orthotopic liver transplantation? J Controversies Biomed Res 2017; 3(2):1-5 Originalpublikation Volltext Tsikas D Does the Inhibitory Action of Asymmetric Dimethylarginine (ADMA) on the Endothelial Nitric Oxide Synthase Activity Explain Its Importance in the Cardiovascular System? The ADMA Paradox. J Controversies Biomed Res 2017; 3(1):16-22 Originalpublikation Volltext Tsikas D Letter to the Editor regarding "Identification of the oleic acid ethanolamide (OEA) isomer cis-vaccenic acid ethanolamide (VEA) as a highly abundant 18:1 fatty acid ethanolamide in blood plasma from rats and humans&quot. Anal.Bioanal Chem. 2017; 409(9):2495- Letter Volltext Tsikas D Measuring NO production rate from l-arginine in MELAS by mass spectrometry-based approaches: GC-MS or LC-MS/MS? Int.J.Cardiol. 2017; DOI: 10.1016/j.ijcard.2017.11.040- Letter Volltext Tsikas D Peroxynitrite-mediated 9,10-dihydroxylation of deuterium-labeled oleic acid in human hemolysate to threo- and erythro-dihydroxy-[9,10-2H2]stearic acid. JSM Biochem Mol Biol 2017; 4(2):1027- Originalpublikation Volltext Tsikas D What we-authors, reviewers and editors of scientific work-can learn from the analytical history of biological 3-nitrotyrosine. J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1058:68-72 Übersicht Volltext Tsikas D, Böhmer A S-Transnitrosation reactions of hydrogen sulfide (H2S/HS-/S2-) with S-nitrosated cysteinyl thiols in phosphate buffer of pH 7.4: Results and review of the literature. Nitric Oxide 2017; 65:22-36 Originalpublikation Volltext Tsikas D, Bollenbach A, Savvidou M D Inverse correlation between maternal plasma asymmetric dimethylarginine (ADMA) and birthweight percentile in women with impaired placental perfusion: circulating ADMA as an NO-independent indicator of fetal growth restriction? Amino Acids 2017; DOI: 10.1007/s00726-017-2522-2- Originalpublikation Volltext Tsikas D, Eigendorf J Diet and Exercise and Serum Markers of Oxidative Stress-Letter. Cancer.Prev.Res.(Phila) 2017; 10(8):485-486 Letter Volltext Tsikas D, Hanff E Lacking linearity in quantitative stable-isotope LC-MS/MS measurement of F2-isoprostanes is an irrefutable indicator of analytical inadequacy. J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci. 2017; 1064:139-142 Übersicht Volltext Tsikas D, Hanff E, Becker T Drastic decrease of global l-arginine bioavailability during orthotopic liver transplantation: A matter of ATP deficiency of the graft? Nitric Oxide 2017;73: 96-97; DOI: 10.1016/j.niox.2017.02.009- Letter Volltext Tsikas D, Hanff E, Bollenbach A S-Adenosyl-L-methionine towards hepatitis C virus expression: Need to consider S-adenosyl-L-methionine's chemistry, physiology and pharmacokinetics. World J.Gastroenterol. 2017; 23(40):7343-7346 Letter Volltext Tsikas D, Hanff E, Brunner G Helicobacter pylori, Its Urease and Carbonic Anhydrases, and Macrophage Nitric Oxide Synthase. Trends Microbiol. 2017; 25(8):601-602 Letter Volltext Tsikas D, Hanff E, Brunner G Spermidine for a long, dementia-free life? Glob J Pharmaceu Sci 2017; 2(1):GJPPS.MS.ID.555576- Übersicht Volltext Tsikas D, Kinzel M Associations between asymmetric dimethylarginine (ADMA), nitrite-dependent renal carbonic anhydrase activity and plasma testosterone levels in hypogonadal men. Hellenic J.Cardiol. 2017; DOI: 10.1016/j.hjc.2017.10.004- Originalpublikation Volltext Tsikas D, Savvidou M Plasma Oleic Acid Oxide in Women at Risk of Preeclampsia Correlates Inversely with Birthweight Centile. JSM Biochem Mol Biol 2017; 4(2):1028- Originalpublikation Volltext Tsikas D, Schwedhelm K S, Surdacki A, Giustarini D, Rossi R, Kukoc-Modun L, Kedia G, Ückert S S-Nitroso-N-acetyl-L-cysteine ethyl ester (SNACET) and N-acetyl-L-cysteine ethyl ester (NACET) Cysteine-based drug candidates with unique pharmacological profiles for oral use as NO, H2S and GSH suppliers and as antioxidants:Results and overview. 2017; 8(1):1-9; DOI: 10.1016/j.jpha.2017.12.003- Originalpublikation Volltext von Elsner L, Hagemann S, Just I, Rohrbeck A Anti-proliferative Effect of C3 Exoenzyme in Fibroblasts is Mediated by c-Jun Phosphorylation. J Mol Signal 2017; 12(1- Originalpublikation Volltext Yao G, Lam K H, Perry K, Weisemann J, Rummel A, Jin R Crystal Structure of the Receptor-Binding Domain of Botulinum Neurotoxin Type HA, Also Known as Type FA or H. Toxins (Basel) 2017; 9(3):93; DOI:10.3390/toxins9030093- Originalpublikation Volltext Yao G, Lam K H, Weisemann J, Peng L, Krez N, Perry K, Shoemaker C B, Dong M, Rummel A, Jin R A camelid single-domain antibody neutralizes botulinum neurotoxin A by blocking host receptor binding. Sci.Rep. 2017; 7(1):7438- Originalpublikation Volltext Zanetti G, Sikorra S, Rummel A, Krez N, Duregotti E, Negro S, Henke T, Rossetto O, Binz T, Pirazzini M Botulinum neurotoxin C mutants reveal different effects of syntaxin or SNAP-25 proteolysis on neuromuscular transmission. PLoS Pathog. 2017; 13(8):DOI: 10.1371/journal.ppat.1006567- Originalpublikation Volltext 2016 Frädrich C, Beer LA, Gerhard R Reactive Oxygen Species as Additional Determinants for Cytotoxicity of Clostridium difficile Toxins A and B Toxins (Basel) 2016; 8 (1), 25 Übersicht Abstract Böhmer A, Pich A, Schmidt M, Haghikia A, Tsikas D Evidence by chromatography and mass spectrometry that inorganic nitrite induces S-glutathionylation of hemoglobin in human red blood cells Journal of Chromatography B. Analyt Technol.Biomed.Life.Sci. 2016; 1019 (72-82) Originalpublikation Abstract Adolf A, Leondaritis G, Rohrbeck A, Eickholt BJ, Just I, Ahnert-Hilger G, Höltje M The intermediate filament protein vimentin is essential for axonotrophic effects of Clostridium botulinum C3 exoenzyme Journal of Neurochemistry 2016; 139 (2): 234-244 Originalpublikation Volltext Dong L, Helmke A, Waisman A, Haller H, Pich A, von Vietinghoff S Surface-bound bovine serum albumin carrier protein as present in recombinant cytokine preparations amplifies T helper 17 cell polarization Scientific Reports 2016; 6 (36598-) Originalpublikation Volltext Dorner BG, Zeleny R, Harju K, Hennekinne JA, Vanninen P, Schimmel H, Rummel A Biological toxins of potential bioterrorism risk: Current status of detection and identification technology TrAC Trends in Analytical Chemistry 2016; 85 (Part B): 89-102 Übersicht Abstract Gerhard R Receptors and Binding Structures for Clostridium difficile Toxins A and B Current Topics in Microbiology and Immunology 2016: 1-18 Originalpublikation Abstract Krueger J, Pohl S, Preusse M, Kordes A, Rugen N, Schniederjans M, Pich A, Häussler S Unravelling post-transcriptional PrmC-dependent regulatory mechanisms in Pseudomonas aeruginosa Environmental Microbiology 2016; 18 (10): 3583-3592 Originalpublikation Volltext Mahrhold S, Bergström T, Stern D, Dorner BG, Astot C, Rummel A Only the complex N559-glycan in the synaptic vesicle glycoprotein 2C mediates high affinity binding to botulinum neurotoxin serotype A1 Biochemical Journal 2016; 473 (17): 2645-2654 Originalpublikation Volltext Rohrbeck A, Fühner V, Schröder A, Hagemann S, Vu XK, Berndt S, Hust M, Pich A, Just I Detection and Quantification of ADP-Ribosylated RhoA/B by Monoclonal Antibody Toxins (Basel) 2016; 8(4):100 Originalpublikation Volltext Tao L, Zhang J, Meraner P, Tovaglieri A, Wu X, Gerhard R, Zhang X, Stallcup WB, Miao J, He X, Hurdle JG, Breault DT, Brass AL, Dong M Frizzled proteins are colonic epithelial receptors for C. difficile toxin B Nature 2016; 538(7625): 350-355 Originalpublikation Volltext von Elsner L, Hagemann S, Just I, Rohrbeck A C3 exoenzyme impairs cell proliferation and apoptosis by altering the activity of transcription factors Naunyn Schmiedeberg's Archives of Pharmacology 2016; 389 (9): 1021-1031 Originalpublikation Volltext Weisemann J, Stern D, Mahrhold S, Dorner BG, Rummel A Botulinum Neurotoxin Serotype A Recognizes Its Protein Receptor SV2 by a Different Mechanism than Botulinum Neurotoxin B Synaptotagmin Toxins (Basel) 2016; 8(5), 154 Originalpublikation Volltext Yao G, Zhang S, Mahrhold S, Lam KH, Stern D, Bagramyan K, Perry K, Kalkum M, Rummel A, Dong M, Jin R N-linked glycosylation of SV2 is required for binding and uptake of botulinum neurotoxin A Nature Structural & Molecular Biology 2016; 23 (7): 656-662 Originalpublikation Volltext Zhang G, Chan B, Samarina N, Abere B, Weidner-Glunde M, Buch A, Pich A, Brinkmann MM, Schulz TF Cytoplasmic isoforms of Kaposi sarcoma herpesvirus LANA recruit and antagonize the innate immune DNA sensor cGAS Proc.Natl.Acad.Sci.U.S.A. 2016; 113 (8): E1034-E1043 Originalpublikation Volltext Junemann J, Birgin G, Erdmann J, Schröder A, Just I, Gerhard R, Pich A Toxin A of the nosocomial pathogen Clostridium difficile induces primary effects in the proteome of HEp-2 cells Germany : WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim, Proteomics Clinical Applications 2016; 11 (3-4) Originalpublikation Volltext Genth H, Schelle I, Just I Metal Ion Activation of Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B Toxins (Basel) 2016; 8 (4): 109 Originalpublikation Volltext Hansbauer EM, Skiba M, Endermann T, Weisemann J, Stern D, Dorner MB, Finkenwirth F, Wolf J, Luginbühl W, Messelhäußer U, Bellanger L, Woudstra C, Rummel A, Fach P, Dorner BG Detection, differentiation, and identification of botulinum neurotoxin serotypes C, CD, D, and DC by highly specific immunoassays and mass spectrometry Analyst 2016; 141 (18): 5281 -5297 Originalpublikation Volltext Kutschenko A, Reinert MC, Krez N, Liebetanz D, Rummel A BoNT/AB hybrid maintains similar duration of paresis as BoNT/A wild-type in murine running wheel assay Netherlands : Elsevier B.V, NeuroToxicology 2016; 59: 1-8 Originalpublikation Abstract Reichert O, Fleming T, Neufang G, Schmelz M, Genth H, Kaever V, Wenck H, Stäb F, Terstegen L, Kolbe L, Roggenkamp D Impaired glyoxalase activity is associated with reduced expression of neurotrophic factors and pro-inflammatory processes in diabetic skin cells Denmark : John Wiley & Sons A/S. Published by John Wiley & Sons Ltd, Experimental Dermatology 2017; 26 (1): 44-50 Originalpublikation Volltext Schelle I, Bruening J, Buetepage M, Genth H Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B Toxins (Basel) 2016; 9 (1), 2 Originalpublikation Volltext 2015 Korf-Klingebiel M, Reboll MR, Klede S, Brod T, Pich A, Polten F, Napp LC, Bauersachs J, Ganser A, Brinkmann E, Reimann I, Kempf T, Niessen HW, Mizrahi J, Schönfeld HJ, Iglesias A, Bobadilla M, Wang Y, Wollert KC Myeloid-derived growth factor (C19orf10) mediates cardiac repair following myocardial infarction Nature medicine 2015;2;2;140-149 Volltext Kull S, Schulz KM, Strotmeier JW, Kirchner S, Schreiber T, Bollenbach A, Dabrowski PW, Nitsche A, Kalb SR, Dorner MB, Barr JR, Rummel A, Dorner BG Isolation and Functional Characterization of the Novel Clostridium botulinum Neurotoxin A8 Subtype PLoS One 2015;10;2 Volltext Rohrbeck A, von Elsner L, Hagemann S, Just I Uptake of Clostridium botulinum C3 Exoenzyme into Intact HT22 and J774A.1 Cells Toxins 2015;7;380-395 Volltext Bothe M, Dutow P, Pich A, Genth H, Klos A DXD motif-dependent and -independent effects of the Chlamydia trachomatis cytotoxin CT166 Toxins 2015;17;621-637 Volltext Haschemi Nassab M, Rhein M, Hagemeier L, Kaeser M, Muschler M, Glahn A, Pich A, Heberlein A, Kornhuber J, Bleich S, Frieling H, Hillemacher T Impaired Regulation of ALDH2 Protein Expression Revealing a Yet Unknown Epigenetic Impact of rs886205 on Specific Methylation of a Negative Regulatory Promoter Region in Alcohol-Dependent Patients. Eur Addict Res 2016;22(2);59 -69 Volltext Lee K, Lam KH, Kruel AM, Mahrhold S, Perry K, Cheng LW, Rummel A, Jin R Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics. Toxicon 2015;107(Pt.A);43 -49 Abstract Reichert O, Kolbe L, Terstegen L, Staeb F, Wenck H, Schmelz M, Genth H, Kaever V, Roggenkamp D, Neufang G UV radiation induces CXCL5 expression in human skin. Exp Dermatol 2015;24(4);309 -312 Volltext Rummel A The long journey of botulinum neurotoxins into the synapse. Toxicon 2015;107(Pt.A):9 -24 Abstract Rohrbeck A, Stahl F, Höltje M, Hettwer T, Lindner P, Hagemann S, Pich A, Haastert-Talini K C3-induced release of neurotrophic factors from Schwann cells - potential mechanism behind its regeneration promoting activity Neurochem Int 2015; 90;232 -245 Abstract Schröder A, Rohrbeck A, Just I, Pich A Proteome Alterations of Hippocampal Cells Caused by Clostridium botulinum C3 Exoenzyme. J Proteome Res 2015;14(11);4721 -4733 Volltext Emmrich S, Engeland F, El-Khatib M, Henke K, Obulkasim A, Schöning J, Katsman-Kuipers JE, Michel Zwaan C, Pich A, Stary J, Baruchel A, de Haas V, Reinhardt D, Fornerod M, van den Heuvel-Eibrink M, Klusmann JH miR-139-5p controls translation in myeloid leukemia through EIF4G2. Oncogene 2015;DOI: 10.1038/onc.2015.247 Volltext Nkuipou-Kenfack E, Bhat A, Klein J, Jankowski V, Mullen W, Vlahou A, Dakna M, Koeck T, Schanstra JP, Zürbig P, Rudolph KL, Schumacher B, Pich A, Mischak H Identification of ageing-associated naturally occurring peptides in human urine. Oncotarget 2015;6(33);34106 -34117 Abstract Saul VV, Niedenthal R, Pich A, Weber F, Schmitz ML SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity. Biochim Biophys Acta 2015;1853(1);136 -143 Volltext Weldearegay YB, Pich A, Schieck E, Liljander A, Gicheru N, Wesonga H, Thiaucourt,F, Kiirika LM, Valentin-Weigand P, Jore J, Meens J Proteomic characterization of pleural effusion, a specific host niche of Mycoplasma mycoides subsp. mycoides from cattle with contagious bovine pleuropneumonia (CBPP). J Proteomics 2015. DOI: 10.1016/j.jprot.2015.10.016 Volltext Keller B, Mühlenkamp M, Deuschle E, Siegfried A, Mössner S, Schade J, Griesinger T, Katava N, Braunsdorf C, Fehrenbacher B, Jimenez-Soto LF, Schaller M, Haas R, Genth H, Retta SF, Meyer H, Böttcher RT, Zent R, Schütz M, Autenrieth IB, Bohn E Yersinia enterocolitica exploits different pathways to accomplish adhesion and toxin injection into host cells. Cell Microbiol 2015;17(8);1179 -1204 Volltext Dorner BG, Rummel A Preface biological Toxins ancient molecules posing a current threat. Toxins 2015;7(12);5320 -5321 Volltext 2014 Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F. Clostridium difficile toxin B inhibits the secretory response of human mast cell line-1 (HMC-1) cells stimulated with high free-Ca and GTPgammaS ,,Toxicology,2015;328():48-56 Originalpublikation Chatterji,B. ; Dickhut,C. ; Mielke,S. ; Krüger,J. ; Just,I. ; Glage,S. ; Meier,M. ; Wedekind,D. ; Pich,A. MALDI imaging mass spectrometry to investigate endogenous peptides in an animal model of Usher's disease , Germany,Proteomics,2014;14(13-14):1674-1687 Originalpublikation Dressler,D. ; Adib Saberi,F. ; Bigalke,H. IncobotulinumtoxinA (Xeomin((R))) can produce antibody-induced therapy failure in a patient pretreated with abobotulinumtoxinA (Dysport((R))) Austria,J.Neural Transm.,2014;121(7):769-771 Case report Dressler,D. ; Gessler,F. ; Tacik,P. ; Bigalke,H. An enzyme-linked immunosorbent assay for detection of botulinum toxin-antibodies United States,Mov.Disord.,2014;29(10):1322-1324 Originalpublikation Genth,H. ; Pauillac,S. ; Schelle,I. ; Bouvet,P. ; Bouchier,C. ; Varela-Chavez,C. ; Just,I. ; Popoff,M. R. Haemorrhagic toxin and lethal toxin from Clostridium sordellii strain vpi9048: molecular characterization and comparative analysis of substrate specificity of the large clostridial glucosylating toxins England,Cell.Microbiol.,2014;16(11):1706-1721 Originalpublikation Gonzalez-Escalona,N. ; Thirunavukkarasu,N. ; Singh,A. ; Toro,M. ; Brown,E. W. ; Zink,D. ; Rummel,A. ; Sharma,S. K. Draft Genome Sequence of Bivalent Clostridium botulinum Strain IBCA10-7060, Encoding Botulinum Neurotoxin B and a New FA Mosaic Type United States,Genome Announc,2014;2(6):10.1128/genomeA.01275-14 Originalpublikation Goy,S. D. ; Olling,A. ; Neumann,D. ; Pich,A. ; Gerhard,R. Human neutrophils are activated by a peptide fragment of Clostridium difficile Toxin B presumably via formyl peptide receptor ,,Cell.Microbiol.,2015;17(6):893-909 Originalpublikation Hardtke-Wolenski,M. ; Taubert,R. ; Noyan,F. ; Sievers,M. ; Dywicki,J. ; Schlue,J. ; Falk,C. S. ; Lundgren,B. A. ; Scott,H. S. ; Pich,A. ; Anderson,M. S. ; Manns,M. P. ; Jaeckel,E. Autoimmune hepatitis in a murine APS-1 model is directed against multiple autoantigens ,,Hepatology,2015;61(4):1295-1305 Originalpublikation Jochim,N. ; Gerhard,R. ; Just,I. ; Pich,A. Time-resolved cellular effects induced by TcdA from Clostridium difficile England,Rapid Commun.Mass Spectrom.,2014;28(10):1089-1100 Originalpublikation Jünger,J. ; Just,I. Recommendations of the German Society for Medical Education and the German Association of Medical Faculties regarding university-specific assessments during the study of human, dental and veterinary medicine Germany,GMS Z.Med.Ausbild,2014;31(3):Doc34- Originalpublikation Konze,S. A. ; van Diepen,L. ; Schröder,A. ; Olmer,R. ; Moller,H. ; Pich,A. ; Weissmann,R. ; Kuss,A. W. ; Zweigerdt,R. ; Buettner,F. F. Cleavage of E-cadherin and beta-catenin by calpain affects Wnt signaling and spheroid formation in suspension cultures of human pluripotent stem cells United States,Mol.Cell.Proteomics,2014;13(4):990-1007 Originalpublikation Lee,K. ; Lam,K. H. ; Kruel,A. M. ; Perry,K. ; Rummel,A. ; Jin,R. High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex United States,Biochem.Biophys.Res.Commun.,2014;446(2):568-573 Originalpublikation Lee,K. ; Zhong,X. ; Gu,S. ; Kruel,A. M. ; Dorner,M. B. ; Perry,K. ; Rummel,A. ; Dong,M. ; Jin,R. Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex United States,Science,2014;344(6190):1405-1410 Originalpublikation Matsui,T. ; Gu,S. ; Lam,K. H. ; Carter,L. G. ; Rummel,A. ; Mathews,I. I. ; Jin,R. Structural Basis of the pH-Dependent Assembly of a Botulinum Neurotoxin Complex England,J.Mol.Biol.,2014;426(22):3773-3782 Originalpublikation May,M. ; Schelle,I. ; Brakebusch,C. ; Rottner,K. ; Genth,H. Rac1-dependent recruitment of PAK2 to G2 phase centrosomes and their roles in the regulation of mitotic entry United States,Cell.Cycle,2014;13(14):2211-2221 Originalpublikation Nkuipou-Kenfack,E. ; Koeck,T. ; Mischak,H. ; Pich,A. ; Schanstra,J. P. ; Zürbig,P. ; Schumacher,B. Proteome analysis in the assessment of ageing ,,Ageing Res.Rev.,2014;18C():74-85 Übersicht Olling,A. ; Hüls,C. ; Goy,S. ; Müller,M. ; Krooss,S. ; Rudolf,I. ; Tatge,H. ; Gerhard,R. The combined repetitive oligopeptides of clostridium difficile toxin A counteract premature cleavage of the glucosyl-transferase domain by stabilizing protein conformation Switzerland,Toxins (Basel),2014;6(7):2162-2176 Originalpublikation Rohrbeck,A. ; Schröder,A. ; Hagemann,S. ; Pich,A. ; Höltje,M. ; Ahnert-Hilger,G. ; Just,I. Vimentin mediates uptake of C3 exoenzyme United States,PLoS One,2014;9(6):e101071- Originalpublikation Rohrbeck,A. ; von Elsner,L. ; Hagemann,S. ; Just,I. Binding of Clostridium botulinum C3 exoenzyme to intact cells Germany,Naunyn Schmiedebergs Arch.Pharmacol.,2014;387(6):523-532 Originalpublikation Rummel,A. ; The dual receptor recognition of botulinum neurotoxins New York, NY,,2014;4():129-150 Buchbeitrag, Monografie Saul,V. V. ; Niedenthal,R. ; Pich,A. ; Weber,F. ; Lienhard Schmitz,M. SUMO modification of TBK1 at the adaptor-binding C-terminal coiled-coil domain contributes to its antiviral activity Netherlands,Biochim.Biophys.Acta,2015;1853(1):136-143 Originalpublikation Strotmeier,J. ; Mahrhold,S. ; Krez,N. ; Janzen,C. ; Lou,J. ; Marks,J. D. ; Binz,T. ; Rummel,A. Identification of the synaptic vesicle glycoprotein 2 receptor binding site in botulinum neurotoxin A Netherlands,FEBS Lett.,2014;588(7):1087-1093 Originalpublikation Wagner,S. ; Maibaum,D. ; Pich,A. ; Nolte,I. ; Murua Escobar,H. Verification of a Canine PSMA (FolH1) Antibody Greece,Anticancer Res.,2015;35(1):145-148 Originalpublikation Wohlan,K. ; Goy,S. ; Olling,A. ; Srivaratharajan,S. ; Tatge,H. ; Genth,H. ; Gerhard,R. Pyknotic cell death induced by Clostridium difficile TcdB: Chromatin condensation and nuclear blister are induced independently of the glucosyltransferase activity ,,Cell.Microbiol.,2014;76(11):1678-1692 Originalpublikation Boetzkes,Alexander Sekretomanalyse hypervirulenter Clostridium difficile-Stämme ,,,2014;():Getr. Zählung- Dissertation Brandes,Vanessa Die durch Tauroursodeoxycholsäure vermittelte Phosphorylierung von Rac1/Cdc42 bewirkt eine reduzierte Glucosylierung katalysiert durch C. difficile Toxin B ,,,2014;():Bl. 77 - 84, Bl. 11 - 43- Dissertation Goy,Sebastian David Clostridium difficile Toxin B activates formyl peptide receptor 1 of human neutrophil granulocytes via N-terminal glucosyltransferase domain ,,,2014;():138 Bl. Ill., graph. Darst.- Dissertation Rotsch,Jacqueline Zelluläre Auswirkungen des bakteriellen Exoenzyms C3 bot ,,,2011;():III, 72 Bl. Ill., graph. Darst.- Dissertation Beer,Lara-Antonia Die Rolle der niedermolekularen GTpase Rac1 und der NADPH Oxidase bei der Clostridium difficile TcdB-induzierten Pyknose ,,,2011;():- Masterarbeit Petersen,Lara Die Rolle von Rho-GTPasen in den zytopathischen und zytotoxischen Wirkungen von Clostridium difficile Toxinen ,,,2011;():62 S.- Masterarbeit Gangl,Anna-Katharina Effekte des marinen Toxins Latrunculin B auf die epitheliale Barrierefunktion des Kolon ,,,2011;():37 S.- Bachelorarbeit 2013 Bagramyan,K. ; Kaplan,B. E. ; Cheng,L. W. ; Strotmeier,J. ; Rummel,A. ; Kalkum,M. Substrates and controls for the quantitative detection of active botulinum neurotoxin in protease-containing samples United States,Anal.Chem.,2013;85(11):5569-5576 Originalpublikation Balletta,A. ; Lorenz,D. ; Rummel,A. ; Gerhard,R. ; Bigalke,H. ; Wegner,F. Human mast cell line-1 (HMC-1) cells exhibit a membrane capacitance increase when dialysed with high free-Ca(2+) and GTPgammaS containing intracellular solution Netherlands,Eur.J.Pharmacol.,2013;720(1-3):227-236 Originalpublikation Barth,H. ; Bigalke,H. ; Gerhard,R. ; Bakterielle Toxine (Kap. 42) Stuttgart,,2013;():1157-1180 Buchbeitrag, Monografie Bigalke,H. Botulinum toxin: application, safety, and limitations Germany,Curr.Top.Microbiol.Immunol.,2013;364():307-317 Originalpublikation Chatterji,B. ; Pich,A. MALDI imaging mass spectrometry and analysis of endogenous peptides England,Expert Rev.Proteomics,2013;10(4):381-388 Originalpublikation Gerhard,R. ; Frenzel,E. ; Goy,S. ; Olling,A. Cellular uptake of Clostridium difficile TcdA and truncated TcdA lacking the receptor binding domain ,,J.Med.Microbiol.,2013;62(9):1414-1422 Originalpublikation Höltje,M. ; Schulze,S. ; Strotmeier,J. ; Mahrhold,S. ; Richter,K. ; Binz,T. ; Bigalke,H. ; Ahnert-Hilger,G. ; Rummel,A. Exchanging the minimal cell binding fragments of tetanus neurotoxin in botulinum neurotoxin A and B impacts their toxicity at the neuromuscular junction and central neurons ,,Toxicon,2013;75C():108-121 Originalpublikation Huelsenbeck,S. C. ; Roggenkamp,D. ; May,M. ; Huelsenbeck,J. ; Brakebusch,C. ; Rottner,K. ; Ladwein,M. ; Just,I. ; Fritz,G. ; Schmidt,G. ; Genth,H. Expression and cytoprotective activity of the small GTPase RhoB induced by the Escherichia coli cytotoxic necrotizing factor 1 Netherlands,Int.J.Biochem.Cell Biol.,2013;45(8):1767-1775 Originalpublikation Lee,K. ; Gu,S. ; Jin,L. ; Le,T. T. ; Cheng,L. W. ; Strotmeier,J. ; Kruel,A. M. ; Yao,G. ; Perry,K. ; Rummel,A. ; Jin,R. Structure of a bimodular botulinum neurotoxin complex provides insights into its oral toxicity United States,PLoS Pathog.,2013;9(10):e1003690- Originalpublikation Mahrhold,S. ; Strotmeier,J. ; Garcia-Rodriguez,C. ; Lou,J. ; Marks,J. D. ; Rummel,A. ; Binz,T. Identification of the SV2 protein receptor-binding site of botulinum neurotoxin type E England,Biochem.J.,2013;453(1):37-47 Originalpublikation May,M. ; Wang,T. ; Müller,M. ; Genth,H. Difference in F-actin depolymerization induced by toxin B from the Clostridium difficile strain VPI 10463 and toxin B from the variant Clostridium difficile serotype F strain 1470 Switzerland,Toxins (Basel),2013;5(1):106-119 Originalpublikation Pirazzini,M. ; Henke,T. ; Rossetto,O. ; Mahrhold,S. ; Krez,N. ; Rummel,A. ; Montecucco,C. ; Binz,T. Neutralisation of specific surface carboxylates speeds up translocation of botulinum neurotoxin type B enzymatic domain Netherlands,FEBS Lett.,2013;587(23):3831-3836 Originalpublikation Rangrez,A. Y. ; Bernt,A. ; Poyanmehr,R. ; Harazin,V. ; Boomgaarden,I. ; Kuhn,C. ; Rohrbeck,A. ; Frank,D. ; Frey,N. Dysbindin is a potent inducer of RhoA-SRF-mediated cardiomyocyte hypertrophy United States,J.Cell Biol.,2013;203(4):643-656 Originalpublikation Rummel,A. Double receptor anchorage of botulinum neurotoxins accounts for their exquisite neurospecificity Germany,Curr.Top.Microbiol.Immunol.,2013;364():61-90 Originalpublikation Scherr,M. ; Elder,A. ; Battmer,K. ; Barzan,D. ; Bomken,S. ; Ricke-Hoch,M. ; Schröder,A. ; Venturini,L. ; Blair,H. J. ; Vormoor,J. ; Ottmann,O. ; Ganser,A. ; Pich,A. ; Hilfiker-Kleiner,D. ; Heidenreich,O. ; Eder,M. ; Differential expression of miR-17~92 identifies BCL2 as a therapeutic target in BCR-ABL positive B-lineage acute lymphoblastic leukemia ,,Leukemia,2014;28(3):554-565 Originalpublikation Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P. The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases United States,PLoS Pathog.,2013;9(11):e1003746- Originalpublikation Schweer,J. ; Kulkarni,D. ; Kochut,A. ; Pezoldt,J. ; Pisano,F. ; Pils,M. C. ; Genth,H. ; Huehn,J. ; Dersch,P. The Cytotoxic Necrotizing Factor of Yersinia pseudotuberculosis (CNFY) Enhances Inflammation and Yop Delivery during Infection by Activation of Rho GTPases United States,PLoS Pathog.,2013;9(11):e1003746- Originalpublikation Steffen,A. ; Ladwein,M. ; Dimchev,G. A. ; Hein,A. ; Schwenkmezger,L. ; Arens,S. ; Ladwein,K. I. ; Holleboom,J. M. ; Schur,F. ; Small,J. V. ; Schwarz,J. ; Gerhard,R. ; Faix,J. ; Stradal,T. E. ; Brakebusch,C. ; Rottner,K. Rac function is critical for cell migration but not required for spreading and focal adhesion formation ,,J.Cell.Sci.,2013;126(Pt.20):4572-4588 Originalpublikation Stevens,G. B. ; Silver,D. A. ; Zgaga-Griesz,A. ; Bessler,W. G. ; Vashist,S. K. ; Patel,P. ; Achazi,K. ; Strotmeier,J. ; Worbs,S. ; Dorner,M. B. ; Dorner,B. G. ; Pauly,D. ; Rummel,A. ; Urban,G. A. ; Krueger,M. Bioluminescence assay for the highly sensitive detection of botulinum neurotoxin A activity ,,Analyst,2013;138(20):6154-6162 Originalpublikation Willjes,G. ; Mahrhold,S. ; Strotmeier,J. ; Eichner,T. ; Rummel,A. ; Binz,T. Botulinum neurotoxin G binds synaptotagmin-II in a mode similar to that of serotype B: tyrosine 1186 and lysine 1191 cause its lower affinity United States,Biochemistry,2013;52(22):3930-3938 Originalpublikation Zeiser,J. ; Gerhard,R. ; Just,I. ; Pich,A. Substrate Specificity of Clostridial Glucosylating Toxins and Their Function on Colonocytes Analyzed by Proteomics Techniques ,,J.Proteome Res.,2013;12(4):1604-1618 Originalpublikation Völker,Anne Katrin Identifizierung und Charakterisierung der Rezeptorbindungstaschen von Botulinum Neurotoxin Serotyp D (BoNTD) ,,,2013;():Getr. Zählung Ill., graph. Darst.- Dissertation Benski,Anastasia ; Analysis of C3bot exoenzyme-dependent ADP-ribosylation of smal Rho-GTPases by Mass Spectrometry ,,,2013;():- Masterarbeit Hüls,Corinna Intrazelluläre Assoziation funtioneller Domänen von Clostridium difficile Toxin A ,,,2013;():- Masterarbeit Raasch,Sabine Hemmung clostridialer glucosylierender Toxine durch tauro- und glucokonjugierte Gallensäuren ,,,2013;():- Masterarbeit Ulfig,Anneli Untersuchung von endogenen Peptiden in Rattenhirnen mittels MALDI Imaging and LC-MS ,,,2013;():- Masterarbeit Völkening,Lea Neutralisierende Wirkung tauro- und glycokonjugierter Gallensäuren auf Clostridium difficile Toxin B ,,,2013;():- Masterarbeit Wohlan,Katharina Rho-abhängige und unabhängige Wirkung von Clostridium difficile Toxin B auf den Zellzyklus ,,,2013;():- Masterarbeit Bollenbach,Alexander Identifizierung der aktivitätsmindernden Aminosäuren der Botulinum Neurotoxin Subtypen A4 und A8 (Chemnitz Stamm) ,,,2012;():- Bachelorarbeit Weigt,David Die Wirkung der Zytotoxisch Nekrotisierenden Faktoren aus Yersinia pseudotuberculosis und Escherichia coli auf die epitheliale Barrierefunktion von kultivierten Nierenepithelzellen ,,,2012;():- Bachelorarbeit 2012 Auer M, Schweigreiter R, Hausott B, Thongrong S, Höltje M, Just I, Bandtlow C, Klimaschewski L. Rho-independent stimulation of axon outgrowth and activation of the ERK and Akt signaling pathways by C3 transferase in sensory neurons. Front Cell Neurosci 2012;6;43 Originalpublikation Baron,J. ; Blex,C. ; Rohrbeck,A. ; Rachakonda,S. K. ; Birnbaumer,L. ; Ahnert-Hilger,G. ; Brunk,I. The alpha-subunit of the trimeric GTPase Go2 regulates axonal growth ,,J.Neurochem.,2013;124(6):782-794 Originalpublikation Bigalke H, Frevert J. Botulinum toxin A: dose and immune response. Int J Rehabil Res 2012;35(2);93 Originalpublikation Boetzkes,A. ; Felkel,K. W. ; Zeiser,J. ; Jochim,N. ; Just,I. ; Pich,A. Secretome analysis of Clostridium difficile strains Germany,Arch.Microbiol.,2012;194(8):675-687 Originalpublikation Brandes V, Schelle I, Brinkmann S, Schulz F, Schwarz J, Gerhard R, Genth H. Protection from C. difficile Toxin B-catalysed Rac/Cdc42 glucosylation by tauroursodeioxycholic acid-induced Rac/Cdc42 phosphorylation. Biol Chem 2012;1;393(1-2);77-84 Originalpublikation Chiaradia,E. ; Avellini,L. ; Tartaglia,M. ; Gaiti,A. ; Just,I. ; Scoppetta,F. ; Czentnar,Z. ; Pich,A. Proteomic evaluation of sheep serum proteins England,BMC Vet.Res.,2012;8():66- Originalpublikation Debez,A. ; Braun,H. P. ; Pich,A. ; Taamalli,W. ; Koyro,H. W. ; Abdelly,C. ; Huchzermeyer,B. Proteomic and physiological responses of the halophyte Cakile maritima to moderate salinity at the germinative and vegetative stages Netherlands,J.Proteomics,2012;75(18):5667-5694 Originalpublikation Gu,S. ; Rumpel,S. ; Zhou,J. ; Strotmeier,J. ; Bigalke,H. ; Perry,K. ; Shoemaker,C. B. ; Rummel,A. ; Jin,R. Botulinum neurotoxin is shielded by NTNHA in an interlocked complex United States,Science,2012;335(6071):977-981 Originalpublikation Hammerschmidt,A. ; Chatterji,B. ; Zeiser,J. ; Schröder,A. ; Genieser,H. G. ; Pich,A. ; Kaever,V. ; Schwede,F. ; Wolter,S. ; Seifert,R. Binding of Regulatory Subunits of Cyclic AMP-Dependent Protein Kinase to Cyclic CMP Agarose United States,PLoS One,2012;7(7):e39848- Originalpublikation Hefter,H. ; Hartmann,C. ; Kahlen,U. ; Moll,M. ; Bigalke,H. Prospective analysis of neutralising antibody titres in secondary non-responders under continuous treatment with a botulinumtoxin type A preparation free of complexing proteins--a single cohort 4-year follow-up study England,BMJ Open,2012;2(4):10.1136/bmjopen-2011-000646. Print 2012 Originalpublikation Huelsenbeck,J. ; May,M. ; Schulz,F. ; Schelle,I. ; Ronkina,N. ; Hohenegger,M. ; Fritz,G. ; Just,I. ; Gerhard,R. ; Genth,H. Cytoprotective effect of the small GTPase RhoB expressed upon treatment of fibroblasts with the Ras-glucosylating Clostridium sordellii lethal toxin Netherlands,FEBS Lett.,2012;586(20):3665-3673 Originalpublikation Hülsenbeck SC, Rohrbeck A, Handreck A, Hellmich G, Kiaei E, Roettinger I, Grothe C, Just I, Haastert-Tallini K. C3 Peptide Promotes Axonal Regeneration and Functional Motor Recovery after Peripheral Nerve Injury Neurotherapeutics 2012;9;185-198 Originalpublikation Katsch,K. ; de Jong,S. J. ; Albrecht,J. C. ; Steger,J. ; Genth,H. ; Posern,G. ; Biesinger,B. Actin-dependent activation of serum response factor in T cells by the viral oncoprotein tip England,Cell.Commun.Signal.,2012;10(1):5-811X-10-5 Originalpublikation May,M. ; Kolbe,T. ; Wang,T. ; Schmidt,G. ; Genth,H. Increased Cell-Matrix Adhesion upon Constitutive Activation of Rho Proteins by Cytotoxic Necrotizing Factors from E. Coli and Y. Pseudotuberculosis United States,J.Signal.Transduct,2012;2012():570183- Originalpublikation Olling A, Seehase S, Minton NP, Tatge H, Schröter S, Kohlscheen S, Pich A, Just I, Gerhard R. Release of TcdA and TcdB from Clostridium cdi 630 is not affected by functional inactivation of the tcdE gene. Microb Pathog 2012;52(1);92-100 Originalpublikation Rohrbeck,A. ; Kolbe,T. ; Hagemann,S. ; Genth,H. ; Just,I. Distinct biological activities of C3 and ADP-ribosyltransferase-deficient C3-E174Q England,FEBS J.,2012;279(15):2657-2671 Originalpublikation Rotsch J, Rohrbeck A, May M, Kolbe T, Hagemann S, Schelle I, Just I, Genth H, Huelsenbeck SC. Inhibition of macrophage migration by C. botulinum exoenzym C3 Naumyn-Schmiedebergs's Arch Pharmacol 2012;385(9);883-90. May29 [Epub ahead of print] Originalpublikation Schwarz,J. ; Proff,J. ; Hävemeier,A. ; Ladwein,M. ; Rottner,K. ; Barlag,B. ; Pich,A. ; Tatge,H. ; Just,I. ; Gerhard,R. Serine-71 phosphorylation of rac1 modulates downstream signaling United States,PLoS One,2012;7(9):e44358- Originalpublikation Strotmeier,J. ; Willjes,G. ; Binz,T. ; Rummel,A. Human synaptotagmin-II is not a high affinity receptor for botulinum neurotoxin B and G: increased therapeutic dosage and immunogenicity Netherlands,FEBS Lett.,2012;586(4):310-313 Originalpublikation Weigoldt,M. ; Meens,J. ; Bange,F. C. ; Pich,A. ; Gerlach,G. F. ; Goethe,R. Metabolic adaptation of Mycobacterium avium subsp. paratuberculosis to the gut environment ,,Microbiology,2013;159(Pt.2):380-391 Originalpublikation Wellhöner,H. ; Weiss,A. ; Schulz,A. ; Adermann,K. ; Braitbard,O. ; Bar-Sinai,A. ; Hochman,J. Reversing ABCB1-mediated multi-drug resistance from within cells using translocating immune conjugates England,J.Drug Target.,2012;20(5):445-452 Originalpublikation Euler,Friederike Christina Bedeutung der Autoproteolyse für die intrazelluläre Wirkung von Clostridium difficile Toxin A ,,,2011;():50 Bl.- Dissertation Fritsch,Cornelia Bindung und Aufnahme von Clostridium botulinum C3 Exoenzym in F98-Zellen ,,,2012;():97 Bl.- Dissertation Janzen,Constantin Identifizierung der SV2-Bindungstasche in der H CC -Domäne von Botulinum Neurotoxin Serotyp A ,,,2012;():[2], 73 Bl.- Dissertation Lica,Marta Anna Unterschiede in der biologischen Wirkung des Clostridium difficile Toxin B in proliferierenden und nicht-proliferierenden Zellen ,,,2011;():[1], 275-283, 10-25 Bl.- Dissertation Roggenkamp,Dennis Funktionelle Charakterisierung der Interaktion von Hautzellen und neuronalen Zellen in gesunder und gestresster Haut ,,,2011;():VI S., S. 7-94, IV S.- Dissertation Schröder,Anke Effekte des C3 Exoenzyms aus Clostridium botulinum auf das Proteom muriner Hippocampuszellen ,,,2012;():VI, 107 Bl. Ill., graph. Darst.- Dissertation Zeiser,Johannes Das Substratspektrum clostridialer glukosylierender Toxine und die Auswirkungen auf das Proteom von Colonozyten ,,,2012;():[7], 3 - 106, [20] Bl.- Dissertation Brinkmann,Sophie Cdk 1 abhängige Phosphorylierung des Rac GEF Proteins beta-Pix ,,,2012;():- Masterarbeit Doberenz,Sebastian ; Kinetische Analyse der Toxin A vermittelten Glukosylierung kleiner GTPasen ,,,2012;():- Masterarbeit Edeling,Maria Funktionelle Charakterisierung von Renalen Tubuluszellen in einem Modell für diabetische Nephropathie ,,,2012;():- Masterarbeit Findeisen,Katja Neutralisation von Clostridium difficile Toxin B durch Tauro-konjugierte-Gallensäuren ,,,2012;():- Masterarbeit Krüger,Jonas Ribosomale Proteomanalyse C3 Exoenzym behandelter Zellen ,,,2012;():- Masterarbeit Nolte,Annika Die Rac1-induzierte Hochregulation von Frizzled-Rezeptoren ,,,2012;():- Masterarbeit Rataj,Dennis Beteiligung von CIC-5 an der zellulären Aufnahme der clostridialen Toxine TcdA und TcdA1-1874 ,,,2012;():- Masterarbeit 2011 Boer U, Lohrenz A, Klingenberg M, Pich A, Haverich A, Wilhelmi M. The effect of detergent-based decellularization procedures on cellular proteins and immunogenicity in equine carotid artery grafts. Biomaterials 2011;32;9730-9737 Originalpublikation Gabaev I, Steinbrück L, Pokoyski C, Pich A, Stanton RJ, Schwinzer R, Schulz TF, Jacobs R, Messerle M, Kay-Federov PC. The Human Cytomegalovirus UL11 Protein Interacts with the Receptor Tyrosine Phosphatase CD45, Resulting in Functional Paralysis of T Cells.PLoS Pathog 2011;7(12) Originalpublikation Gerhard R, Queißer S, Tatge H, Meyer G, Dittrich-Breiholz O, Kracht M, Feng H, Just I. Down-regulation of interleukin-16 in human mast cells HMC-1 by Clostridium difficile toxins A and B Naunyn Schmiedebergs Arch Pharmacol 2011;383;285-295 Originalpublikation Höltje M, Just I, Ahnert-Hilger G. Clostridial C3 proteins: Recent approaches to improve neuronal growth and regeneration. Ann Anat 2011;193(4);314-320 Originalpublikation Jochim N, Gerhard R, Just I, Pich A. Impact of clostridial glucosylating toxins on the proteome of colonic cells determined by isotype-coded protein labeling and LC-MALDI. Proteome Sci 2011;9;48 Originalpublikation Lica M, Schulz F, Schelle I, May M, Just I, Genth H. Difference in the biological effects of Clostridium difficile B in profilerating and non-proliferating cells. Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);275-283 Originalpublikation Mueller MQ, Zeiser JJ, Dreiocker F, Pich A, Schaefer M, Sinz A. An universal matrix-assisted laser desorption/ionization cleavable cross-linker for protein structure analysis. Rapid Commun Mass Spectrom 2011;25(1);155-161 Originalpublikation Nölle A, Zeug A, van Bergeijk, Tönges L, Gerhard R, Brinkmann H, Al Rayes S, Hensel N, Schill Y, Apkhazava D, Jablonka S, Omer J, Srivastrav RK, Baasner A, Lingor P, Wirth B, Ponimaskin E, Niedenthal R, Grothe C, Claus P. The Spinal Muscular Atrophy disease protein SMN is linked to the Rho-kinase pathway via profilin. Human molecular genetics 2011;15;20(24);4865-4878 Originalpublikation Olling A, Goy S, Hoffmann F, Tatge H, Just I, Gerhard R. The repetitive oligopeptide sequences modulate cytopathic potency but are not crucial for cellular uptake of Clostridium difficile toxin A. PLoS One 2011;18;6(3) e17623 Originalpublikation Oumeraci T, Schmidt B, Wolf T, Zapatka M, Pich A, Brors B, Eils R, Fleischhacker M, Schlegelberger B, v. Neuhoff N. Bronchoalveolar lavage fluid of lung cancer patients: mapping the uncharted waters using proteomics technology. Lung Cancer 2011;72(1);136-138 Originalpublikation Puklowski A, Homsi Y, Keller D, May M, Chauhan S, Kossatz U, Grünwald V, Kubicka S, Pich A, Manns MP, Hoffmann I, Gönczy P, Malek NP. The SCF-Fbxw5 E3-ubiquitin ligase is regulated by Plk4 and targets HsSAS-6 to control centrosome duplication. Nat Cell Biol 2011;13(8);1004-1009 Originalpublikation Rost BR, Nicholson P, Ahnert-Hilger G, Rummel A, Rosenmund C, Breustedt J, Schmitz D. Activation of metabotropic GABA receptors increases the energy barrier for vesicle fusion. J Cell Science 2011;15;124(Pt18);3066-73 Originalpublikation Rummel A, Mahrhold S, Bigalke H, Binz T. Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin. FEBS J 2011;278(23);4506-4515 Originalpublikation Rummel,A. Molecular biology of Clostridium botulinum organism and botulinum neurotoxins, insight into the molecular machinery involved in Clostridium botulinum neurotoxity ,Hauppauge, N.Y.,,2011;():37-70 Buchbeitrag, Monografie Rummel,A. ; Mahrhold,S. ; Bigalke,H. ; Binz,T. Exchange of the H(CC) domain mediating double receptor recognition improves the pharmacodynamic properties of botulinum neurotoxin ,,FEBS J.,2011;278(23):4506-4515 10.1111/j.1742-4658.2011.08196.x Originalpublikation Schacht T, Unger C, Pich A, Wydra K. Endo- and exopolygalacturonases of Ralstonia solanacearum are inhibited by polygalacturonase-inhibiting protein (PGIP) activity in tomato stem extracts. Plant Physiol Biochem 2011;49(4);377-387 Originalpublikation Schulte-Baukloh H, Herholz J, Bigalke H, Miller K, Knispel HH. Results of a BoNT/A Antibody Study in Children and Adolescents after Onabotulinumtoxin A (Botox(R)) Detrusor Injection. Urol Int 2011;87(4);434-438 Originalpublikation Strotmeier J, Gu S, Jutzi S, Mahrhold S, Zhou J, Pich A, Eichner T, Bigalke H, Rummel A, Jin R, Binz T. The biological activity of botulinum neurotoxin type C is dependent upon novel types of ganglioside binding sites. Mol Microbiol 2011;81(1);143-156 Originalpublikation Wolf T, Oumeraci T, Gottlieb J, Pich A, Brors B, Eils R, Haverich A, Schlegelberger B, Welte T, Zapatka M, von Neuhoff N. Proteomic Bronchiolitis Obliterans Syndrome Risk Monitoring in Lung Transplant Recipients. Transplantation 2011;92(4);477-485 Originalpublikation Zeiser J, Klodmann J, Braun HP, Gerhard R, Just I, Pich A. Effects of Clostridium difficile Toxin A on the proteome of colonocytes studied by differential 2D electrophoresis. Journal of Proteomics 2011;75;469-479 Originalpublikation Felkel,Katharina-Wiebke LC-MS basierte Sekretomanalyse verschiedener Clostridium difficile Stämme ,,,2010;():104 Bl.- Dissertation Halabi Cabezon,Ismael Aufhebung des zytopathischen Effekts von Clostridium difficile Toxin B durch Rac1 Aktivierung ,,,2010;():3751-3756, 7-20 Bl.- Dissertation Jochim,Nelli LC-MS-basierte globale Proteomanalyse von Colonzellen nach Behandlung mit clostridialen glucosylierenden Toxinen ,,,2011;():XVII, 124 Bl.- Dissertation Kreimeyer,Isa Die autoproteolytische Spaltung beeinflusst den zytotoxischen Effekt von Clostridium difficile Toxin A ,,,2010;():36 Bl.- Dissertation Lücke,Nina Sekretomanalyse der hämatopoetischen Progenitorzelllinie DKmix ,,,2010;():46 Bl.- Dissertation May,Martin Role of Rac1 and PAK in the regulation of G2-M transition and mitotic cell rounding ,,,2011;():[7], 79 Bl.- Dissertation Schrader,Merle Korrelation der C. difficile Toxin A-induzierten Apoptose mit der Hochregulation des GTP-bindenden Proteins RhoB ,,,2011;():62 Bl.- Dissertation Werner,Stefan Charakterisierung der zellulären Aufnahme von C. botulinum C3-Exoenzym ,,,2010;():[3], 86 Bl.- Dissertation Dickhut,Clarissa Bildgebende Massenspektrometrie zur histologischen Analyse von Geweben ,,,2010;():- Masterarbeit Frenzel,Eileen Charakterisierung der zellulären Aufnahme der C. difficile Toxine TcdA und TcdA1-1874 ,,,2010;():- Masterarbeit Lentes,Jana Auswirkungen der GTP-Beladung auf die Glucosylierung von Rho Proteinen durch Clostridien Toxine ,,,2011;():- Bachelorarbeit 2010 Adler,S. ; Bicker,G. ; Bigalke,H. ; Bishop,C. ; Blumel,J. ; Dressler,D. ; Fitzgerald,J. ; Gessler,F. ; Heuschen,H. ; Kegel,B. ; Luch,A. ; Milne,C. ; Pickett,A. ; Ratsch,H. ; Ruhdel,I. ; Sesardic,D. ; Stephens,M. ; Stiens,G. ; Thornton,P. D. ; Thürmer,R. ; Vey,M. ; Spielmann,H. ; Grune,B. ; Liebsch,M. The current scientific and legal status of alternative methods to the LD50 test for botulinum neurotoxin potency testing. The report and recommendations of a ZEBET Expert Meeting England,Altern.Lab.Anim.,2010;38(4):315-330 Originalpublikation Backert S, Kenny B, Gerhard R, Tegtmeyer N, Bran S. PKA-mediated phosphorylation of EPEC-Tir at serine residues 434 and 463: A novel pathway in regulating Rac1 GTPase function. Gut Microbes 2010;1(2);94-99 Originalpublikation Dahal,D. ; Pich,A. ; Braun,H. P. ; Wydra,K. Analysis of cell wall proteins regulated in stem of susceptible and resistant tomato species after inoculation with Ralstonia solanacearum: a proteomic approach Netherlands,Plant Mol.Biol.,2010;73(6):643-658 10.1007/s11103-010-9646-z Originalpublikation Darios F, Niranjan D, Ferrari E, Zhang F, Soloviev M, Rummel A, Bigalke H, Suckling J, Ushkaryov Y, Naumenko N, Shakirzyanova A, Giniatullin R, Maywood E, Hastings M, Binz T, Davletov B. SNARE tagging allows stepwise assembly of a multimodular medicinal toxin. Proc Natl Acad Sci USA 2010;107(42);18197-18201 Originalpublikation Genth H, Just I. Functional implications of lethal toxin-catalysed glucosylation of (H/K/N)Ras and Rac1 in Clostridium sordellii-associated disease. Eur J Cell Biol 2010;12(4);Epub ahead of print Originalpublikation Genth H, Schulz F, Just I. Gluscosylation of Rho/Ras Proteins by Lethal Toxin - Implication of Actin Re-Organization and Apoptosis in C. Sordellii-Associated Disease. Open Toxinology 2010;3;13-18 Originalpublikation Just I, Hülsenbeck SC, Genth H. Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and a Neurotrophic Agent. Open Toxinology 2010;3;19-23 Originalpublikation Just I, Rohrbeck A, Huelsenbeck SC, Hoeltje M. Therapeutic effects of Clostridium botulinum C3 exoenzyme. Naunyn Schmiedebergs Arch Pharmacol 2011;383(3);247-52; Epub 2010 Übersicht Kreimeyer I, Euler F, Marckscheffel A, Tatge H, Pich A, Olling A, Schwarz J, Just I, Gerhard R. Autoproteolytic cleavage mediates cytotoxicity of Clostridium difficile toxin A. Naunyn Schmiedebergs Arch Pharmacol 2010;11(3); Epub 2010 Originalpublikation Krückeberg J, Just I, Möbs D, Matthies H, Fischer V. Mehrwert erkannt, Defizite gebannt? - die quantitative Analyse elektronisch verfasster Klausuren an der Medizinischen Hochschule Hannover. GMA [Hrsg.]: Jahrestagung der Gesellschaft für Medizinische Ausbildung (GMA). Bochum, 23.-25.09.2010 Vortrag Luecke N, Templin C, Muetzelburg MV, Neumann D, Just I, Pich A. Secreted proteome of the murine multipotent hematopoietic progenitor cell line DKmix. Rapid Commun Mass Spectrom 2010;24(5);561-570 Originalpublikation Naue N, Fedorov R, Pich A, Manstein DJ, Curth U. Site-directed mutagenesis of the {chi} subunit of DNA polymerase III and single-stranded DNA-binding protein of E. coli reveals key residues for their interaction. Nucleic Acids Res 2010;23(10); Epub ahead of print Originalpublikation Strotmeier J, Lee K, Völker AK, Mahrhold S, Zong Y, Zeiser J, Zhou J, Pich A, Bigalke H, Binz T, Rummel A, Jin R. Botulinum neurotoxin serotype D attacks neurons via two carbohydrate-binding sites in a ganglioside-dependent manner. Biochem J 2010;431(2):207-216 Originalpublikation Thalmann J, Janik K, May M, Sommer K, Ebeling J, Hofmann F, Genth H, Klos A. Actin re-organization induced by Chlamydia trachomatis serovar D--evidence for a critical role of the effector protein CT166 targeting Rac. PLoS One 2010;5(3) Originalpublikation Häfner,Kirstin Kompetitionsexperimente am Maus-Hemidiaphragma-Assay zur Identifizierung von Proteinrezeptoren der clostridiellen Neurotoxine: SV2 vermittelt die Aufnahme von BoNT/F in neuronale Zellen ,,,2010;():- Dissertation Lange,Oliver Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A : much ado about nothing? ,,,2010;():213 - 218, 16 Bl.- Dissertation Nottrott,Stefanie Die Clostridium difficile Toxin A-induzierte Apoptose ist unabhängig von p53, aber abhängig von der Glucosylierung von Rho-GTPasen ,,,2010;():[1], 33 Bl.- Dissertation Supthut,Hauke Intra- und extrazelluläre Faktoren, die die Sensitivität von CHO-Zellen gegenüber Clostridium difficile Toxin B bestimmen ,,,2009;():89 Bl.- Dissertation Barlag,Britta Beteiligung von IQGAP und MRCK an der Phospho-Rac1-vermittelten Filopodienbildung ,,,2010;():- Masterarbeit Goy,Sebastian Bedeutung der Rezeptorbindedomäne von Clostridium difficile Toxin A für die Funktionalität ,,,2010;():- Masterarbeit Kolbe,Tanja Wirkung Rho-modifizierter bakterieller Toxine in einem in vitro Modell der Wundheilung ,,,2010;():- Diplomarbeit Wang,Tianbang F-Aktin Depolymerisation durch clostridiale Toxine ,,,2010;():- Diplomarbeit 2009 Andresen,H. ; Bingel,U. ; Streichert,T. ; Schmoldt,A. ; Zoerner,A. A. ; Tsikas,D. ; Just,I. Severe glycerol intoxication after Meniere's disease diagnostic--case report and overview of kinetic data England,Clin.Toxicol.(Phila),2009;47(4):312-316 10.1080/15563650902849123 Originalpublikation Binz,T. ; Rummel,A. Cell entry strategy of clostridial neurotoxins England,J.Neurochem.,2009;109(6):1584-1595 10.1111/j.1471-4159.2009.06093.x Originalpublikation Brunger,A. T. ; Rummel,A. Receptor and substrate interactions of clostridial neurotoxins England,Toxicon,2009;54(5):550-560 10.1016/j.toxicon.2008.12.027 Originalpublikation Deplazes,J. ; Fuchs,M. ; Rauser,S. ; Genth,H. ; Lengyel,E. ; Busch,R. ; Luber,B. ; Rac1 and Rho contribute to the migratory and invasive phenotype associated with somatic E-cadherin mutation England,Hum.Mol.Genet.,2009;18(19):3632-3644 10.1093/hmg/ddp312 Originalpublikation Dreger,S. C. ; Schulz,F. ; Huelsenbeck,J. ; Gerhard,R. ; Hofmann,F. ; Just,I. ; Genth,H. Killing of Rat Basophilic Leukemia Cells by Lethal Toxin from Clostridium sordellii: Critical Role of Phosphatidylinositide 3'-OH Kinase/Akt Signaling (dagger) ,,Biochemistry,2009;():- 10.1021/bi800708b Originalpublikation Genth H, Schulz F, Just I. Glucosylation of Rho/Ras Proteins by Lethal Toxin - Implications of Actin-Re-Organization and Apoptosis in C. Sordellii-Associated Disease. The Open Toxinology Journal 2009;2 Abstract Huelsenbeck,S. C. ; Klose,I. ; Reichenbach,M. ; Huelsenbeck,J. ; Genth,H. Distinct kinetics of (H/K/N)Ras glucosylation and Rac1 glucosylation catalysed by Clostridium sordellii lethal toxin Netherlands,FEBS Lett.,2009;583(19):3133-3139 10.1016/j.febslet.2009.09.006 Originalpublikation Huelsenbeck,S. C. ; May,M. ; Schmidt,G. ; Genth,H. Inhibition of cytokinesis by Clostridium difficile toxin B and cytotoxic necrotizing factors--reinforcing the critical role of RhoA in cytokinesis United States,Cell Motil.Cytoskeleton,2009;66(11):967-975 10.1002/cm.20390 Originalpublikation Just I, Hülsenbeck SC, Genth H. Clostridium Botulinum C3 Exoenzyme: Rho-Inactivating Tool in Cell Biology and an Neurothrophic Agent. The Open Toxinology Journal 2009;2 Abstract Kotz,A. ; Wagener,J. ; Engel,J. ; Routier,F. ; Echtenacher,B. ; Pich,A. ; Rohde,M. ; Hoffmann,P. ; Heesemann,J. ; Ebel,F. The mitA gene of Aspergillus fumigatus is required for mannosylation of inositol-phosphorylceramide, but is dispensable for pathogenicity ,,Fungal Genet.Biol.,2010;47(2):169-178 10.1016/j.fgb.2009.10.001 Originalpublikation Lange,O. ; Bigalke,H. ; Dengler,R. ; Wegner,F. ; deGroot,M. ; Wohlfarth,K. Neutralizing antibodies and secondary therapy failure after treatment with botulinum toxin type A: much ado about nothing? United States,Clin.Neuropharmacol.,2009;32(4):213-218 10.1097/WNF.0b013e3181914d0a Originalpublikation Mohammadi,B. ; Buhr,N. ; Bigalke,H. ; Krampfl,K. ; Dengler,R. ; Kollewe,K. A long-term follow-up of botulinum toxin A in cervical dystonia ,,Neurol.Res.,2009;31(5):463-466 10.1179/174313209X405137 Originalpublikation Mohammadi,B. ; Kollewe,K. ; Wegener,M. ; Bigalke,H. ; Dengler,R. Experience with long-term treatment with albumin-supplemented botulinum toxin type A Austria,J.Neural Transm.,2009;116(4):437-441 10.1007/s00702-009-0200-6 Originalpublikation Nerlich,A. ; Rohde,M. ; Talay,S. R. ; Genth,H. ; Just,I. ; Chhatwal,G. S. Invasion of endothelial cells by tissue-invasive M3 type group A streptococci requires Src kinase and activation of Rac1 by a phosphatidylinositol 3-kinase-independent mechanism United States,J.Biol.Chem.,2009;284(30):20319-20328 10.1074/jbc.M109.016501 Originalpublikation Rummel,A. ; Häfner,K. ; Mahrhold,S. ; Darashchonak,N. ; Holt,M. ; Jahn,R. ; Beermann,S. ; Karnath,T. ; Bigalke,H. ; Binz,T. Botulinum neurotoxins C, E and F bind gangliosides via a conserved binding site prior to stimulation-dependent uptake with botulinum neurotoxin F utilising the three isoforms of SV2 as second receptor England,J.Neurochem.,2009;110(6):1942-1954 10.1111/j.1471-4159.2009.06298.x Originalpublikation Schoentaube,J. ; Olling,A. ; Tatge,H. ; Just,I. ; Gerhard,R. Serine-71 phosphorylation of Rac1/Cdc42 diminishes the pathogenic effect of Clostridium difficile toxin A ,,Cell.Microbiol.,2009;11(12):1816-1826 10.1111/j.1462-5822.2009.01373.x Originalpublikation Schulz,F. ; Just,I. ; Genth,H. Prevention of Clostridium sordellii lethal toxin-induced apoptotic cell death by tauroursodeoxycholic acid United States,Biochemistry,2009;48(38):9002-9010 10.1021/bi900964c Originalpublikation Sun,X. ; He,X. ; Tzipori,S. ; Gerhard,R. ; Feng,H. Essential role of the glucosyltransferase activity in Clostridium difficile toxin-induced secretion of TNF-alpha by macrophages England,Microb.Pathog.,2009;46(6):298-305 10.1016/j.micpath.2009.03.002 Originalpublikation von Witzendorff,D. ; Maass,K. ; Pich,A. ; Ebeling,S. ; Kölle,S. ; Kochel,C. ; Ekhlasi-Hundrieser,M. ; Geyer,H. ; Geyer,R. ; Töpfer-Petersen,E. Characterization of the acidic N-linked glycans of the zona pellucida of prepuberal pigs by a mass spectrometric approach Netherlands,Carbohydr.Res.,2009;344(12):1541-1549 10.1016/j.carres.2009.05.002 Originalpublikation Goltz,Björn Tetanustoxin und Botulinumtoxin A : Interaktion mit Mastzellen aus der Bauchfellhöhle der Ratte ,,,2008;():IV, 140 S.- Dissertation Teichert,Matthias Charakterisierung von mutiertem Clostridium difficile Toxin A zur Bestimmung von Glucosyltransferase-abhängigen Effekten ,,,2007;():11 Bl.- Dissertation 2008 Busche,S. ; Descot,A. ; Julien,S. ; Genth,H. ; Posern,G. Epithelial cell-cell contacts regulate SRF-mediated transcription via Rac-actin-MAL signalling England,J.Cell.Sci.,2008;121(Pt 7):1025-1035 10.1242/jcs.014456 Originalpublikation Genth,H. ; Dreger,S. C. ; Huelsenbeck,J. ; Just,I. Clostridium difficile toxins: More than mere inhibitors of Rho proteins England,Int.J.Biochem.Cell Biol.,2008;40(4):592-597 10.1016/j.biocel.2007.12.014 Originalpublikation Gerhard,R. ; Nottrott,S. ; Schoentaube,J. ; Tatge,H. ; Olling,A. ; Just,I. Glucosylation of Rho GTPases by Clostridium difficile toxin A triggers apoptosis in intestinal epithelial cells England,J.Med.Microbiol.,2008;57(Pt 6):765-770 10.1099/jmm.0.47769-0 Originalpublikation Halabi-Cabezon,I. ; Huelsenbeck,J. ; May,M. ; Ladwein,M. ; Rottner,K. ; Just,I. ; Genth,H. Prevention of the cytopathic effect induced by Clostridium difficile Toxin B by active Rac1 Netherlands,FEBS Lett.,2008;582(27):3751-3756 10.1016/j.febslet.2008.10.003 Originalpublikation Hoffmann,A. ; Hofmann,F. ; Just,I. ; Lehnardt,S. ; Hanisch,U. K. ; Brück,W. ; Kettenmann,H. ; Ahnert-Hilger,G. ; Höltje,M. Inhibition of Rho-dependent pathways by Clostridium botulinum C3 protein induces a proinflammatory profile in microglia United States,Glia,2008;56(11):1162-1175 10.1002/glia.20687 Originalpublikation Höltje,M. ; Djalali,S. ; Hofmann,F. ; Münster-Wandowski,A. ; Hendrix,S. ; Boato,F. ; Dreger,S. C. ; Grosse,G. ; Henneberger,C. ; Grantyn,R. ; Just,I. ; Ahnert-Hilger,G. A 29-amino acid fragment of Clostridium botulinum C3 protein enhances neuronal outgrowth, connectivity, and reinnervation ,,FASEB J.,2009;23(4):1115-1126/10.1096/fj.08-116855 Originalpublikation Höltje,M. ; Hofmann,F. ; Lux,R. ; Veh,R. W. ; Just,I. ; Ahnert-Hilger,G. Glutamate uptake and release by astrocytes are enhanced by Clostridium botulinum C3 protein United States,J.Biol.Chem.,2008;283(14):9289-9299 10.1074/jbc.M706499200 Originalpublikation Kamanova,J. ; Kofronova,O. ; Masin,J. ; Genth,H. ; Vojtova,J. ; Linhartova,I. ; Benada,O. ; Just,I. ; Sebo,P. Adenylate cyclase toxin subverts phagocyte function by RhoA inhibition and unproductive ruffling United States,J.Immunol.,2008;181(8):5587-5597 Originalpublikation Klisch,K. ; Jeanrond,E. ; Pang,P. C. ; Pich,A. ; Schuler,G. ; Dantzer,V. ; Kowalewski,M. P. ; Dell,A. A tetraantennary glycan with bisecting N-acetylglucosamine and the Sd(a) antigen is the predominant N-glycan on bovine pregnancy-associated glycoproteins England,Glycobiology,2008;18(1):42-52 10.1093/glycob/cwm113 Originalpublikation Kühnel,T. S. ; Schulte-Mattler,W. ; Bigalke,H. ; Wohlfarth,K. Treatment of habitual snoring with botulinum toxin: a pilot study ,,Sleep Breath,2008;12(1):63-68 10.1007/s11325-007-0136-8 Originalpublikation Muetzelburg,M. V. ; Hofmann,F. ; Just,I. ; Pich,A. Identification of biomarkers indicating cellular changes after treatment of neuronal cells with the C3 exoenzyme from Clostridium botulinum using the iTRAQ protocol and LC-MS/MS analysis ,,J.Chromatogr.B.Analyt Technol.Biomed.Life.Sci.,2009;877(13):1344-1351 10.1016/j.jchromb.2008.12.005 Originalpublikation Neumann,D. ; Kollewe,C. ; Pich,A. ; Cao,P. ; Resch,K. ; Martin,M. U. Threonine 66 in the death domain of IRAK-1 is critical for interaction with signaling molecules but is not a target site for autophosphorylation United States,J.Leukoc.Biol.,2008;84(3):807-813 10.1189/jlb.0507290 Originalpublikation Sander,L. E. ; Frank,S. P. ; Bolat,S. ; Blank,U. ; Galli,T. ; Bigalke,H. ; Bischoff,S. C. ; Lorentz,A. Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells Germany,Eur.J.Immunol.,2008;38(3):855-863 10.1002/eji.200737634 Originalpublikation Schulte-Baukloh,H. ; Bigalke,H. ; Miller,K. ; Heine,G. ; Pape,D. ; Lehmann,J. ; Knispel,H. H. Botulinum neurotoxin type A in urology: antibodies as a cause of therapy failure Australia,Int.J.Urol.,2008;15(5):407-15; discussion 415 10.1111/j.1442-2042.2008.02016.x Originalpublikation Stolz,A. ; Haines,N. ; Pich,A. ; Irvine,K. D. ; Hokke,C. H. ; Deelder,A. M. ; Gerardy-Schahn,R. ; Wuhrer,M. ; Bakker,H. Distinct contributions of beta4GalNAcTA and beta4GalNAcTB to Drosophila glycosphingolipid biosynthesis United States,Glycoconj.J.,2008;25(2):167-175 10.1007/s10719-007-9069-5 Originalpublikation Tschernig,T. ; Neumann,D. ; Pich,A. ; Dorsch,M. ; Pabst,R. Experimental bronchial asthma - the strength of the species rat Netherlands,Curr.Drug Targets,2008;9(6):466-469 Originalpublikation 2007 Conrad S, Genth H, Hofmann F, Just I, Skutella T. Neogenin-RGMa signaling at the growth cone Is BMP-independent and involves RhoA, rock and PKC. J Biol Chem 2007;282(22);16423-33 Abstract Fessler MB, Arndt PG, Just I, Nick JA, Malcolm KC, Worthen GS. Dual role for RhoA in suppression and induction of cytokines in the human neutrophil. Blood 2007;109(3);1248-1256 Abstract Frommberger M, Zürbig P, Jantos J, Krahn T, Mischak H, Pich A, Just I,Schmitt-Kopplin P, Schiffer E. Peptidomic analysis of rat urine using capillary electrophoresis coupled to mass spectrometry. Proteomics 2007;1(7);650-60 Abstract Huelsenbeck J, Dreger S, Gerhard R, Barth H, Just I, Genth H. Difference in the cytotoxic effects of toxin B from Clostridium difficile strain VPI 10463 and toxin B from variant Clostridium difficile strain 1470. Inf Immun 2007;75(2);801-809 Abstract Huelsenbeck J, Dreger S, Gerhard R, Fritz G, Just I, Genth H. Up-regulation of the immediate early gene product RhoB by exoenzyme C3 from Clostridium limosum and toxin B from Clostridium difficile. Biochemistry 2007;24;46(16);4923-31 Abstract Jin R, Sikorra S, Stegmann CM, Pich A, Binz T, Brunger AT. Neurotoxin serotype C1 light chain protease: implications for dual substrate specificity. Biochemistry 2007;46;10685-93 Abstract Klisch K, Jeanrond E, Pang PC, Pich A, Schuller G, Dantzer V, Kowalewski MP, Dell A. A tetraantennary glycan with bisecting N-Acetylglucosamine and Sda antigen is the predominant N-glycan on bovine Pregnancy-associated glycoproteins. Glycobiology 2008;18(1);42-52; Epub 2007 Abstract Meyer GK, Neetz A, Brandes G, Tsikas D, Butterfield JH, Just I, Gerhard R. Clostridium difficile Toxin A and B directly stimulate human mast cells. Inf Immun 2007;21(5) Abstract Nottrott S, Schoentaube J, Genth H, Just I, Gerhard R. Apoptosis induced by Clostridium difficile Toxin A is p53-independent and tiggered by glucosylation of Rho GTPases. Apoptosis 2007;12(8);1443-53 Abstract Rummel A, Eichner T, Weil T, Karnath T, Gutcaits A, Mahrhold S, Sandhoff K, Proia RL, Acharya KR, Bigalke H, Binz T. Identification of the receptor binding site of botulinum neurotoxins B and G proves the double receptor concept. PNAS 2007;104;359-364 Abstract Stolz A, Haines N, Pich A, Irvine KD, Hokke CH, Deelder AM, Gerardy-Schahn R, Wuhrer M, Bakker H. Distinct contributions of β4GalNAcTA and β4GalNAcTB to Drosophila glycospingolipid biosynthesis. Glycoconj J 2008;25(2);167-75; Epub 2007 Abstract 2006 Foster K, Bigalke H, Aoki R. Botulinum Neurotoxin - From Laboratory to Bedside Neurotoxicity Research 2006;9;133-140 Abstract Genth H, Huelsenbeck J, Hartmann B, Hofmann F, Just I, Gerhard R. Cellular stability of Rho-GTPases glucosylated by Clostridium difficile toxin B. FEBS Lett 2006;580;3565-3569 Abstract Giesemann T, Jank T, Gerhard R, Maier E, Just I, Benz R, Aktories K. Cholesterol-dependent pore formation of Clostridium difficile toxin A. J Biol Chem 2006;281;10808-10815 Abstract Jin R, Rummel A, Binz T, Brunger AT. Botulinum neurotoxin B recognizes its protein receptor with high affinity and specificity Nature 2006;444;1092-1095 Abstract Lee SH, Bigalke H. Botulinumtoxin – Pharmakologie, Sicherheit und sekundäre Non-Response durch Antikörper Neuropädiatrie in Klinik und Praxis 2006;5;52-56 Übersicht Mahrhold S, Rummel A, Bigalke H, Davletov B, Binz T. The synaptic vesicle protein 2C mediates the uptake of botulinum neurotoxin A into phrenic nerves. FEBS Lett 2006;Apr3;580(8);2011-4 Abstract Molinari G, Rohde M, Wilde C, Just I, Aktories K, Chhatwal G.S. Localization of the C3-like ADP-ribosyltransferase from Staphylococcus aureus during baterial invasion of mammalian cells. Inf Immun 2006;74;3673-3677 Abstract Rosales RL, Bigalke H, Dressler D. Pharmacology of botulinum toxin: differences between type A preparations. Eur J Neurol; 2006;13;2-10 Abstract Schröder O, Gerhard R, Stein J. Antibiotic-associated diarrhea Diarrhö Z Gastroenterol 2006;44(2);193-204 Abstract Stange DE, Radlwimmer B, Schubert F, Traub F, Pich A, Toedt G, Mendrzyk F, Lehmann U, Eils R, Kreipe H, Lichter, P. High resolution genomic profiling reveals association of chromosomal aberrations on 1q and 16p with histologic and genetic subgroups of invasive breast cancer. Clin Cancer Res 2006;12;345-52 Abstract Teichert M, Tatge H, Schoentaube J, Just I, Gerhard R. Application of mutated Clostridium difficile toxin A for determination of Glucosyltransferase-dependent effects. Inf Immun 2006;74(10);6006-6010 Abstract Theodorescu D, Wittke S, Ross MM, Walden M, Conaway M, Just I, Mischak H, Frierson HF. Discovery and validation of new protein biomarkers for urothelial cancer: a prospective analysis. Lancet Oncol 2006;7(3);230-40 Abstract Traub F, Jost M, Hess R, Schorn K, Menzel C, Budde P, Schulz-Knappe P, Lamping N, Pich A, Kreipe H, Tammen H. Peptidomic analysis of breast cancer reveals a putative surrogate marker for estrogen receptor-negative carcinomas. Lab Invest 2006;86;246-253 Abstract Zürbig P, Renfrow MB, Schiffer E, Novak J, Walden M, Wittke S, Just I, Pelzig M, Neusüß C, Theodorescu D, Root KE, Ross MM, Mischak H. Biomarker discovery by CE.MS enables sequences analysis via MS/MS with platform-independent separation. Electrophoresis 2006;27(11);2111-21125 Abstract 2001 Barth H, Pfeifer G, Hofmann F, Maier E, Benz R, Aktories K. Low pH-induced formation of ion channels by Clostridium difficile toxin B in target cells. J Biol Chem. 2001 Apr 6; 276(14): 10670-6. Abstract Bigalke H, Wohlfarth K, Irmer A, Dengler R. Botulinum A toxin: Dysport improvement of biological availability. Exp Neurol. 2001 Mar;168(1):162-70. Abstract Dreikhausen U, Varga G, Hofmann F, Barth H, Aktories K, Resch K, Szamel M. Regulation by rho family GTPases of IL-1 receptor induced signaling: C3-like chimeric toxin and Clostridium difficile toxin B inhibit signaling pathways involved in IL-2 gene expression. Eur J Immunol. 2001 May; 31(5): 1610-9. Abstract Gülke I, Pfeifer G, Liese J, Fritz M, Hofmann F, Aktories K, Barth H. Characterization of the enzymatic component of the ADP-ribosyltransferase toxin CDTa from Clostridium difficile. Infect Immun. 2001 Oct;69(10):6004-11. Abstract Just I, Hofmann F, Genth H, Gerhard R. Bacterial protein toxins inhibiting low-molecular-mass GTP-binding proteins. Int J Med Microbiol. 2001 Sep;291(4):243-50. Abstract Klussmann E, Tamma G, Lorenz D, Wiesner B, Maric K, Hofmann F, Aktories K, Valenti G, Rosenthal W. An inhibitory role of Rho in the vasopressin-mediated translocation of aquaporin-2 into cell membranes of renal principal cells. J Biol Chem. 2001 Jun 8; 276(23): 20451-7. Abstract Rollnik JD, Wohlfarth K, Dengler R, Bigalke H. Neutralizing botulinum toxin type a antibodies: clinical observations in patients with cervical dystonia. Neurol Clin Neurophysiol. 2001;2001(3):2-4. Abstract Schnittler HJ, Schneider SW, Raifer H, Luo F, Dieterich P, Just I, Aktories K. Role of actin filaments in endothelial cell-cell adhesion and membrane stability under fluid shear stress. Pflugers Arch. 2001 Aug;442(5):675-87. Abstract Walev I, Bhakdi SC, Hofmann F, Djonder N, Valeva A, Aktories K, Bhakdi S. Delivery of proteins into living cells by reversible membrane permeabilization with streptolysin-O. Proc Natl Acad Sci U S A. 2001 Mar 13;98(6):3185-90. Abstract Wilde C, Chhatwal GS, Schmalzing G, Aktories K, Just I. A novel C3-like ADP-ribosyltransferase from Staphylococcus aureus modifying RhoE and Rnd3. J Biol Chem 2001 Mar 23;276(12):9537-42 Abstract Yang SN, Yu J, Mayr GW, Hofmann F, Larsson O, Berggren PO. Inositol hexakisphosphate increases L-type Ca2+ channel activity by stimulation of adenylyl cyclase. FASEB J. 2001 Aug;15(10):1753-63. Abstract 2000 Bigalke H. Neuromuskuläre Verbindung – Präsynaptisches Terminal. Klin. Neurophysiol 2000;31;115-121 Busch C, Hofmann F, Gerhard R, Aktories K. Involvement of a conserved tryptophan residue in the UDP-glucose binding of large clostridial cytotoxin glycosyltransferases. J Biol Chem. 2000 May 5;275(18):13228-34. Abstract Busch C, Schömig K, Hofmann F, Aktories K. Characterization of the catalytic domain of Clostridium novyi alpha-toxin. Infect Immun. 2000 Nov;68(11):6378-83. Abstract Dressler D, Bigalke H, Rothwell JC. The sternocleidomastoid test: an in vivo assay to investigate botulinum toxin antibody formation in humans. J Neurol. 2000 Aug;247(8):630-2. Abstract Dressler D, Dirnberger G, Bhatia KP, Irmer A, Quinn NP, Bigalke H, Marsden CD. Botulinum toxin antibody testing: comparison between the mouse protection assay and the mouse lethality assay. Mov Disord. 2000 Sep;15(5):973-6. Abstract Dressler D, Zettl U, Benecke R, Bigalke H. Can intravenous immunoglobulin improve antibody-mediated botulinum toxin therapy failure? Mov Disord. 2000 Nov;15(6):1279-81. Abstract Galmiche A, Rassow J, Doye A, Cagnol S, Chambard JC, Contamin S, de Thillot V, Just I, Ricci V, Solcia E, Van Obberghen E, Boquet P. The N-terminal 34 kDa fragment of Helicobacter pylori vacuolating cytotoxin targets mitochondria and induces cytochrome c release. EMBO J. 2000 Dec 1;19(23):6361-70. Abstract Genth H, Selzer J, Busch C, Dumbach J, Hofmann F, Aktories K, Just I. New method to generate enzymatically deficient Clostridium difficile toxin B as an antigen for immunization. Infect Immun. 2000 Mar;68(3):1094-101. Abstract Just I, Boquet P Large clostridial cytotoxins as tools in cell biology. Curr Top Microbiol Immunol 2000;250;97-107 Review Just I, Hofmann F, Aktories K Molecular mode of action of the large clostridial cytotoxins. Curr Top Microbiol Immunol 2000;250;55-83 Review Lehnardt S, Ahnert-Hilger G, Bigalke H, Jöns T. Acid secretion of parietal cells is paralleled by a redistribution of NSF and alpha, beta-SNAPs and inhibited by tetanus toxin Histochem Cell Biol. 2000 Nov;114(5):387-91. Abstract Linseman DA, Hofmann F, Fisher SK. A role for the small molecular weight GTPases, Rho and Cdc42, in muscarinic receptor signaling to focal adhesion kinase. J Neurochem. 2000 May;74(5):2010-20. Abstract Meyer DK, Olenik C, Hofmann F, Barth H, Leemhuis J, Brunig I, Aktories K, Nörenberg W. Regulation of somatodendritic GABAA receptor channels in rat hippocampal neurons: evidence for a role of the small GTPase Rac1. J Neurosci. 2000 Sep 15;20(18):6743-51. Abstract Procyk KJ, Rippo MR, Testi R, Hofmann F, Parker PJ, Baccarini M. Lipopolysaccharide induces jun N-terminal kinase activation in macrophages by a novel Cdc42/Rac-independent pathway involving sequential activation of protein kinase C zeta and phosphatidylcholine-dependent phospholipase C. Blood. 2000 Oct 1;96(7):2592-8. Abstract Rollnik JD, Matzke M, Wohlfarth K, Dengler R, Bigalke H. Low-dose treatment of cervical dystonia, blepharospasm and facial hemispasm with albumin-diluted botulinum toxin type A under EMG guidance. An open label study. Abstract Vetter IR, Hofmann F, Wohlgemuth S, Herrmann C, Just I. Structural consequences of mono-glucosylation of Ha-Ras by Clostridium sordellii lethal toxin. J Mol Biol. 2000 Sep 1;301(5):1091-5. Abstract Wagner AH, Köhler T, Rückschloss U, Just I, Hecker M. Improvement of nitric oxide-dependent vasodilatation by HMG-CoA reductase inhibitors through attenuation of endothelial superoxide anion formation. Arterioscler Thromb Vasc Biol. 2000 Jan;20(1):61-9. Abstract Wilde C, Genth H, Aktories K, Just I. Recognition of RhoA by Clostridium botulinum C3 exoenzyme. J Biol Chem. 2000 Jun 2;275(22):16478-83. Abstract 1999 Feick P, Gilhaus S, Blum R, Hofmann F, Just I, Schulz I. Inhibition of amylase secretion from differentiated AR4-2J pancreatic acinar cells by an actin cytoskeleton controlled protein tyrosine phosphatase activity. FEBS Lett. 1999 May 28;451(3):269-74. Abstract Fritz G, Just I, Kaina B. Rho GTPases are over-expressed in human tumors. Int J Cancer. 1999 May 31;81(5):682-7. Abstract Genth H, Aktories K, Just I. Monoglucosylation of RhoA at threonine 37 blocks cytosol-membrane cycling. J Biol Chem. 1999 Oct 8;274(41):29050-6. Abstract Jöns T, Lehnardt S, Bigalke H, Heim HK, Ahnert-Hilger G. SNARE proteins and rab3A contribute to canalicular formation in parietal cells. Eur J Cell Biol. 1999 Nov;78(11):779-86. Abstract Nörenberg W, Hofmann F, Illes P, Aktories K, Meyer DK. Rundown of somatodendritic N-methyl-D-aspartate (NMDA) receptor channels in rat hippocampal neurones: evidence for a role of the small GTPase RhoA. Br J Pharmacol. 1999 Jul;127(5):1060-3. Abstract 1998 Adermann K, Raida M, Paul Y, Abu-Raya S, Bloch-Shilderman E, Lazarovici P, Hochman J, Wellhoner H. Isolation, characterization and synthesis of a novel paradaxin isoform. FEBS Lett. 1998 Sep 18;435(2-3):173-7. Abstract Barth H, Hofmann F, Olenik C, Just I, Aktories K. The N-terminal part of the enzyme component (C2I) of the binary Clostridium botulinum C2 toxin interacts with the binding component C2II and functions as a carrier system for a Rho ADP-ribosylating C3-like fusion toxin. Infect Immun. 1998 Apr;66(4):1364-9. Abstract Barth H, Preiss JC, Hofmann F, Aktories K. Characterization of the catalytic site of the ADP-ribosyltransferase Clostridium botulinum C2 toxin by site-directed mutagenesis. J Biol Chem. 1998 Nov 6;273(45):29506-11. Abstract Ben-Ami G, Ozeri V, Hanski E, Hofmann F, Aktories K, Hahn KM, Bokoch GM, Rosenshine I. Agents that inhibit Rho, Rac, and Cdc42 do not block formation of actin pedestals in HeLa cells infected with enteropathogenic Escherichia coli. Infect Immun. 1998 Apr;66(4):1755-8. Abstract Boquet P, Munro P, Fiorentini C, Just I. Toxins from anaerobic bacteria: speficity and molecular mechanism of action. Curr Opinion Microbiol 1998;1;66-74 Abstract Busch C, Hofmann F, Selzer J, Munro S, Jeckel D, Aktories K. A common motif of eukaryotic glycosyltransferases is essential for the enzyme activity of large clostridial cytotoxins. J Biol Chem. 1998 Jul 31;273(31):19566-72. Abstract Gerhard R, Schmidt G, Hofmann F, Aktories K. Activation of Rho GTPases by Escherichia coli cytotoxic necrotizing factor 1 increases intestinal permeability in Caco-2 cells. Infect Immun. 1998 Nov;66(11):5125-31. Abstract Herrmann C, Ahmadian MR, Hofmann F, Just I. Functional consequences of monoglucosylation of Ha-Ras at effector domain amino acid threonine 35. J Biol Chem. 1998 Jun 26;273(26):16134-9. Abstract Hofmann F, Busch C, Aktories K. Chimeric clostridial cytotoxins: identification of the N-terminal region involved in protein substrate recognition. Infect Immun. 1998 Mar;66(3):1076-81. Abstract Lucius C, Arner A, Steusloff A, Troschka M, Hofmann F, Aktories K, Pfitzer G. Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins. J Physiol. 1998 Jan 1;506 ( Pt 1):83-93. Abstract Naumann M, Toyka KV, Mansouri Taleghani B, Ahmadpour J, Reiners K, Bigalke H. Depletion of neutralising antibodies resensitises a secondary non-responder to botulinum A neurotoxin. J Neurol Neurosurg Psychiatry. 1998 Dec;65(6):924-7. Abstract Paul Y, Weiss A, Adermann K, Erdmann G, Kassebaum C, Lazarovici P, Hochman J, Wellhoner H. Translocation of acylated pardaxin into cells. FEBS Lett. 1998 Nov 27;440(1-2):131-4. Abstract Reiser CO, Lanz T, Hofmann F, Hofer G, Rupprecht HD, Goppelt-Struebe M. Lysophosphatidic acid-mediated signal-transduction pathways involved in the induction of the early-response genes prostaglandin G/H synthase-2 and Egr-1: a critical role for the mitogen-activated protein kinase p38 and for Rho proteins. Biochem J. 1998 Mar 15;330 ( Pt 3):1107-14. Abstract Schmid G, Schürmann A, Huppertz C, Hofmann F, Aktories K, Joost HG. Inhibition of insulin-stimulated glucose transport in 3T3-L1 cells by Clostridium difficile toxin B, Clostridium sordellii lethal toxin, and Clostridium botulinum C2 toxin. Naunyn Schmiedebergs Arch Pharmacol. 1998 Apr;357(4):385-92. Abstract Sehr P, Joseph G, Genth H, Just I, Pick E, Aktories K. Glucosylation and ADP ribosylation of rho proteins: effects on nucleotide binding, GTPase activity, and effector coupling. Biochemistry. 1998 Apr 14;37(15):5296-304. Abstract Wohlfarth K, Goeschel H, Frevert J, Dengler R, Bigalke H. Dose standardisation of botulinum toxin: Reply. Mov Disord. 1998, 13, 750-751. Abstract 1997 Goschel, H., Wohlfarth, K., Frevert, J., Dengler, R., Bigalke, H. Botulinum A toxin therapy: neutralizing and nonneutralizing antibodies - therapeutic consequences. Exp. Neurol. 147, 1997, 96-102. Abstract Hippenstiel, S., Tannert-Otto, S., Vollrath, N., Krüll, M., Just, I., Aktories, K., von Eichel-Streiber, C., Suttorp, N. Glucosylation of small GTP-binding Rho proteins disrupts endothelial barrier function. Am. J. Physiol. 1997, 272, L38-L43. Abstract Hofmann, F., Busch, C., Prepens, U., Just, I., Aktories, K. Localization of the glucosyltransferase activity of Clostridium difficile toxin B to the N-terminal part of holotoxin. J. Biol. Chem. 1997, 272, 11074-11078. Abstract Olenik, C., Barth, H., Just, I., Aktories, K., Meyer, D.K. Gene expression of the small GTP binding proteins RhoA, RhoB, Rac1, and Cdc42 in adult brain. Mol. Brain Res. 1997, 52, 272-279. Abstract Otto, B., Steusloff, A., Just, I., Aktories, K., Pfitzer, G. Role of Rho proteins in carbachol-induced contractions in intact and permeabilized guinea pig intestinal smooth muscle. J. Physiol. (Lond.), 1997, 496, 317-329. Abstract Verschueren, H., de Baetselier, P., de Braekeleer, J., Dewitt, J., Aktories, K., Just, I. ADP-ribosylation of Rho-proteins with botulinum C3 exoenzyme inhibits invasion and shape changes of T-lymphoma cells. Eur. J. Cell Biol. 1997, 73, 182-187. Abstract Wohlfarth, K., Goschel, H., Frevert, J., Dengler, R., Bigalke, H. Botulinum A toxins: units versus units. Naunyn Schmiedebergs Arch. Pharmacol. 1997, 355, 335-40. Abstract