Ergebnis lasse sich nicht quantifizieren. Genaktivitäten dagegen lassen sich genau messen. Je aktiver ein Gen ist, desto mehr Boten-RNS (messenger-RNA) produziert es. Mit Hilfe von Genmustern können die Absto [...] wissenschaftlichen Kooperationspartner an der kanadischen Universität Edmonton festgestellt, welche Gene bei frühen und späten Abstoßungsreaktionen, an denen unterschiedliche Immunzell-Typen beteiligt sind
Structural Analysis of microRNAs in Myeloid Cancer Reveals Consensus Motifs. Genes 13, 1152. https://doi.org/10.3390/genes13071152 2020 Karatas, M., Dogan, S., Spahiu, E. , Ašić, A., Bešić, L., Turan,
proteins, the structure of DNA can be altered (chromatin remodeling) in such a way that individual genes are switched on and off in a spatio–temporal manner. Short RNA species and posttranscriptional RNA [...] replication in clinical cohorts, but also try to understand how specific regulation of a particular gene leads to (non) response to specific therapies. To answer these questions, we use animal and cell culture [...] Wiehlmann, L., Maier, H. B., Eberle, F., Bleich, S., Neyazi, A., & Frieling, H. (2020). Novel candidate genes for ECT response prediction-a pilot study analyzing the DNA methylome of depressed patients receiving
Reports. 2021. Publisher's page Predicting genotoxicity of viral vectors for stem cell gene therapy using gene expression-based machine learning Schwarzer, Adrian, Talbot, Steven R., Selich, Anton, Morgan [...] page Identification and functional characterization of a spliced rhesus rhadinovirus gene with homology to the K15 gene of Kaposi's sarcoma-associated herpesvirus. Wang L, Pietrek M, Brinkmann MM, Havemeier [...] antisense noncoding RNA, EVA1A-AS, suppresses the expression of Myc/Max dependent anti-proliferating gene EVA1A in a U2 dependent manner Niehus, Svenja E., Allister, Aldrige B., Hoffmann, Andrea, Wiehlmann
expression and contractile function are altered by replating stem cell–derived cardiomyocytes, (2023), J Gen Physiol (2023) 155 (11): e202313377, https://doi.org/10.1085/jgp.202313377 , Online ahead of print [...] protein kinases mediate recruitment of CREB-binding protein to preserve fast myosin heavy chain IId/x gene activity in myotubes. J. Biol. Chem., 282, 7265-7275. da Costa, N., Edgar, J., Ooi, P.-T., Su, Y. [...] Meissner, J.D. , and Chang, K.-C., 2007. Calcineurin differentially regulates fast myosin heavy chain genes in oxidative muscle fibre type conversion. Cell Tissue Res., 329, 515-27. Hanke, N., Meissner, J.D
J, Klein C, Schambach A „Lentiviral Gene Therapy and Vitamin B3 Treatment Enable Granulocytic Differentiation of G6PC3-deficient Induced Pluripotent Stem Cells“ Gene Ther 2020 Feb 12 [Online ahead of print] [...] Moritz T, Trapnell BC, Lachmann N. “Function and Safety of Lentivirus-Mediated Gene Transfer for CSF2RA-Deficiency” Hum Gene Ther Methods . 2017 Dec;28(6):318-329 Ackermann M, Kuhn A, Kunkiel J, Merkert [...] Moritz T. „Chemoprotection of murine hematopoietic cells by combined gene transfer of cytidine deaminase (CDD) and multidrug resistance 1 gene (MDR1).“ J Exp Clin Cancer Res . 2015 Dec 12;34:148 Dreyer AK, Hoffmann
cilia in the early embryo (Ben Abdelkhalek et al , Beckers et al , Alten et al ), and have identified genes with unknown functions that are regulated downstream of Noto and encode good candidates for novel [...] components important for motile cilia formation and/or function (Stauber et al 2017). Disruption of these genes in mice cause phenotypes resembling parts or the full spectrum of PCD in human patients (e.g. Weidemann
ankungen im europäischen Raum. In über 80 % der Fälle liegt eine homozygote C282Y-Mutation im HFE-Gen vor, welche eine Fehlfaltung des HFE Proteins verursacht. Dies wiederum hat eine gestörte Expression [...] klassische CRISPR/Cas Technologie im Labor zu einem nützlichen Werkzeug für die Ausschaltung von Genen macht. Deutlich schwieriger gestaltet sich allerdings die Korrektur einer Punktmutation oder gar das
bestimmten Mutationen des CFTR-Gens steigt die Hoffnung, bald auch eine ursächliche Therapie für mehr Patienten zu finden. Mehr als 2.000 verschiedene Mutationen des CFTR-Gens sind für unterschiedliche Defekte
Clinial Translation“ The publication „Hahn/Pollmann et al. 2020“ sets the foundation for the first gene therapy of IFNgR1-deficient MSMD. The authors reverse cells from patients with lentiviral vectors [...] targeting infections of the lower respiratory tract. Excellence in Research Award The American Society for Gene and Cell Therapy (ASGCT) awards the work of Kathrin Haake with an “Excellence in Research” award.