Charakterisierung von DNA-Proben. Zur Analyse der Methylierungsmuster in der Promotorregion bestimmter Gene kam in den letzten 10 Jahren vor allem die Bisulfit-Sequenzierung (nach Sanger) zum Einsatz. Aktuell [...] psychometrischen Daten korreliert. Dadurch können Zusammenhänge zwischen der Regulation relevanter Gene und der Ausprägung psychisch auffälliger Verhaltensmuster nachgewiesen werden. Das Labor für Molekulare

2015 Apr 24. PMID: 25911549 Free PMC article. Clinical Trial. No abstract available. A novel G6PC3 gene mutation in severe congenital neutropenia: pancytopenia and variable bone marrow phenotype can also [...] Mutat. 2013 Jun;34(6):905-14. doi: 10.1002/humu.22308. Epub 2013 Apr 2. PMID: 23463630 A novel G6PC3 gene mutation in a patient with severe congenital neutropenia. Aytekin C, Germeshausen M, Tuygun N, Dogu [...] Sep;37(6):673-81. doi: 10.1055/s-0031-1291377. Epub 2011 Nov 18. PMID: 22102270 Review. Lentiviral gene transfer regenerates hematopoietic stem cells in a mouse model for Mpl-deficient aplastic anemia.

Mohr I. Targeting the m6A RNA modification pathway blocks SARS-CoV-2 and HCoV-OC43 replication. Genes & Dev . 2021 https://doi.org/10.1101/gad.348320.121 Ouwendijk WJD*, Depledge DP* , Rajbhandari L, [...] GMGM, Sadaoka T. Expression of varicella-zoster virus VLT-ORF63 fusion transcript induces broad viral gene expression during reactivation from neuronal latency. Nature Comms. 2020. https://doi.org/10.1038 [...] L, Mohr I. RNA m6A modification enzymes shape innate responses to DNA by regulating interferon β. Genes & Dev. 2018. https://doi.org/10.1101/gad.319475.118 Depledge DP* , Ouwendijk WJD*, Sadaoka T*, Braspenning

characterization and subtyping of breast cancer cell lines provide novel insight into cancer relevant genes. Cells 13:301 Schaumann N, Bartels S, Kuehnle E, Kreipe H, and Christgen M* (2024). Malignant phyllodes [...] (2024). Frequency of genetic alterations differs in advanced breast cancer between metastatic sites. Genes Chromosomes Cancer 63:e23199 Cserni G, Kalman E, Udvarhelyi N, Papp E, Grote I, Bartels S, Christgen [...] Wurstlein R, Shak S, Baehner F, Kreipe HH, and Harbeck N (2022). Endocrine Therapy Response and 21-Gene Expression Assay for Therapy Guidance in HR+/HER2- Early Breast Cancer. J Clin Oncol 40:2557-2567

S Table 2 S Lehmann et al. (2002) Promoter hypermethylation in the death-associated protein kinase gene in breast cancer is associated with the invasive lobular subtype DAP_K_CAN.htm Startseite Veröffe

Hematopoiesis Further publications: Gene Therapy Vectorology / Biosafety Regenerative Medicine 2022 Real-Time Characterization of Clonal Fate Decisions in Complex Leukemia Samples by Fluorescent Genetic [...] ):723-731 DOI: 10.1038/s41586-022-04587-3 Evaluation of lentiviral vectors for the human cell and gene therapy of IFN-γR1-deficient mendelian susceptibility to mycobacterial disease. Hahn, Katharina Klara [...] FR. Cell. 2018 Jun 28;174(1):88-101.e16. doi: 10.1016/j.cell.2018.05.028. UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells. Ngom M, Imren S, Maetzig T, Adair JE

Using the CRISPR/Cas9-GMNN Fusion Gene.,Gerlach M, Kraft T, Brenner B, Petersen B, Niemann H, Montag J. , Genes (Basel). 2018 Jun 13;9(6). pii: E296. doi: 10.3390/genes9060296, Journal High Intensity High [...] der allelischen Imbalance durch Mutationen des MYH7-Gens, AG Montag Ernstberger,Pia Dr. med., Ungleiche allelische Expression bei Mutationen im MYH7-Gen bei Hypertropher Kardiomyopathie : mRNA-Quantifizierung [...] induces cachexia by impeding transcriptional signaling of the SET1/MLL complex on muscle-specific genes, Bushra Khan , Chiara Lanzuolo, Valentina Rosti, Philina Santarelli, Andreas Pich, Theresia Kraft

OE 6710, project: Pseudomonas aeruginosa - mammalian host cell interaction: Phagocyte-sensitizing genes of P. aeruginosa Final exam November 2006 Anuhar Chaturvedi INDIA supervisor: PD Dr. Eder, Hematology [...] 2006 Eric Hesse (Dr. med.) GERMANY supervisor: Prof. Dr. Krettek; Trauma Surgery, OE6230, project: Gene-expression analysis of mesenchymal stem cells and their matrix synthesis Final exam November 2007

Dr. Schambach / Dr. Adrian Schwarzer, Experimental Hematology, OE 6960, project: Using inducible gene expression and RNAi to investigate murine models of acute T-cell leukemia in vivo Final exam November [...] Pediatric Pneumology, OE 6710, project: Functional analysis of regulatory variants of modifying genes that determine the outcome of the monogenic disease cystic fibrosis Final exam November 2016. Nurullah

PM, Reimers K (2015). Identification of reference genes and validation for gene expression studies in diverse axolotl (Ambystoma mexicanum) tissues. Gene , 560 (1), 114-123. Fülbier A, Schnabel R, Michael