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remove bacteria from the blood stream: results of the first in human study. Crit Care. 2022 Jun 17;26(1):181. doi: 10.1186/s13054-022-04044-7. PMID: 35715801. Schmidt JJ, Borchina DN, Van't Klooster M, B [...] undergoing prolonged intermittent renal replacement therapy. J Antimicrob Chemother. 2021 Dec 24;77(1):169-173. doi: 10.1093/jac/dkab357. PMID: 34586373 Schmidt JJ, Strunk AK, David S, Bode-Böger SM, M [...] injury undergoing prolonged intermittent renal replacement therapy. J Antimicrob Chemother. 2019 Apr 1;74(4):997-1002. doi: 10.1093/jac/dky511. PMID: 30624668 Schmidt JJ, Lueck C, Ziesing S, Stoll M, Haller

detail for the NOD protein Apaf-1, the key switch in the mitochondrial pathway of apoptosis. Combining structural information from the X-ray structure of auto-inhibited Apaf-1 and the cryo-EM structure of [...] speck-like protein containing a caspase activation and recruitment domain ), and the effector pro-caspase 1. The transition from inactive monomer to active oligomer is characteristic for NOD proteins, to which [...] of the apoptosome, we depicted the conformational changes of Apaf-1, which eventually lead to the transduction of the cellular death signal. To understand the dynamics of the activation of NLRPs, we structurally

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model for mortality and cardiovascular outcomes in older adults taking into account AZGP1. Sci Rep. 2021 Jun 3;11(1):11792. Haddad G, Kölling M, Wegmann UA, Dettling A, Seeger H, Schmitt R, Soerensen-Zender [...] emeinschaft PI: SCHM 2146/11-1, 2022-2025 Senolyse bei Nierenerkrankung: Therapeutisches Potential und Risiken Sponsor: Deutsche Forschungsgemeinschaft PI: SCHM 2146/10-1, 2020-2024 Offen Stellen und [...] Sörensen-Zender I, Rong S, Haller H, Schmitt R. The Therapeutic Potential of Zinc-Alpha2-Glycoprotein (AZGP1) in Fibrotic Kidney Disease. Int J Mol Sci. 2022 Jan 7;23(2):646. Liao CM, Wulfmeyer VC, Swallow M,

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School Carl-Neuberg-Strasse 1 30625 Hannover Principal Coordinating Investigator : Prof. Dr. med. Thomas Skripuletz Clinic for Neurology Hannover Medical School Carl-Neuberg-Strasse 1 30625 Hannover Trial protocol [...] print. Erratum in: JAMA Neurol. 2025 Jun 1;82(6):630. doi: 10.1001/jamaneurol.2025.1019. Combined treatment with allogeneic Epstein-Barr- and human polyomavirus 1 specific T-cells in progres-sive multifocal [...] Maecker-Kolhoff B, Eiz-Vesper B. J Clin Immunol. 2022 Apr;42(3):546-558. doi: 10.1007/s10875-021-01205-1. Epub 2022 Jan 6. Rapid generation of clinical-grade antiviral T cells: selection of suitable T-cell

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