(2020) : Kirsch C, Doyle I, Krause O, Junius-Walker U, Wiese B, Thürmann P, Sparenberg L, Wollny A, Fuchs A, Wilm S, Joos S, Stolz R, Haumann H. ‘‘Lessons learned’’ – Herausforderungen im Rekrutierungsprozess [...] Studie wird von mehreren allgemeinmedizinischen Instituten durchgeführt, unterstützt werden diese u.a. durch die Klinische Pharmakologie (Universität Witten-Herdecke) und vier Landesapothekerkammern. Aktuelles [...] Die Aufbereitung und Auswertung der Studiendaten ist abgeschlossen. Die ersten Ergebnisse wurden u.a. auf dem Weltkongress der Hausärzte (WONCA) in Berlin im Dezember 2020 präsentiert. Die Hauptpublikation

erfasst: Carnitin-Transporter-Defekt, Citrullinämie, 3-Hydroxy-3-Methylglutaryl-CoA-Lyase-Mangel, Propionacidämie, Multipler Acyl-CoA-Dehydrogenase-Mangel (Glutaracidurie Typ II), Störungen der Remethylierung [...] . PubMed PMID: 39040028. Bekri S, Bley A, Brown HA, Chanson C, Church HJ, Gelb MH, Hong X, Janzen N, Kasper DC, Mechtler T, Morton G, Murko S, Oliva P, Tebani A, Wu THY. Higher precision, first tier newborn [...] Sickle Cell Disease - Application of Two-Tiered Testing with a qPCR-Based Primary screen. Klin Padiatr. 2023 Nov;235(6):366-372. doi: 10.1055/a-2153-7789. Epub 2023 Sep 25. PubMed PMID: 37748509; PubMed

countries: a panel data analysis. BMJ Open 2024;14:e077765. doi:10.1136/bmjopen-2023-077765 Bartling T , Oedingen C, Schrem H, Kohlmann T, Krauth C (2023). Setting Organ Allocation Priorities: A Discrete [...] allocation: a discrete choice experiment regarding distributive justice. The Patient. 15(6):729-738. Doi: 10.1007/s40271-022-00601-y. Bartling T , Oedingen C, Schrem H, Kohlmann T, Krauth C (2021). ‘As a surgeon [...] C, Bartling T , Dreier M, Spura A, de Bock F, von Rüden U, Betsch C, Korn L, Robra B-P (2021). Public Preferences for exit strategies from COVID-19 lockdown in Germany—A discrete choice experiment. Int

Projects Allosteric regulation of UDP-sugar pyrophosphorylases as a means to develop new anti-parasitic treatments UDP-sugar pyrophosphorylases play a central role in cellular carbohydrate biosynthesis. As metabolic [...] innate immune sensors as a means to control infection and inflammation The innate immune sensors activate interferon-driven antiviral responses upon recognition of PAMPs and serve as a rheostat for the metabolic [...] development of new drugs against protozoan parasites. The current project pursues the goal to obtain a comprehensive description of the allosteric mechanisms regulating UDP-sugar pyrophosphorylases in the

Tourette-Syndrome: Results from a Cerebrospinal Fluid Study. Front Neurol. 2019 Jul 4; 10:732. Sühs KW, Novoselova N, Kuhn M, Seegers L, Kaever V, Muller-Vahl K, et al. Kynurenine is a cerebrospinal fluid biomarker [...] J Neuropathol Exp Neurol 2014 Jun;73(6):507-18. Sühs KW, Hein K, Sattler MB, Gorlitz A, Ciupka C, Scholz K, et al. A randomized, double-blind, phase 2 study of erythropoietin in optic neuritis. Ann Neurol [...] infections. J Infect Dis 2019 Jun 5; 220(1):127-138. Sühs KW, Fairless R, Williams SK, Heine K, Cavalie A, Diem R. N-methyl-D-aspartate receptor blockade is neuroprotective in experimental autoimmune optic

31278348; PMCID: PMC6611798. Kapanadze T, Bankstahl JP, Wittneben A, Koestner W, Ballmaier M, Gamrekelashvili J, Krishnasamy K, Limbourg A, Ross TL, Meyer GJ, Haller H, Bengel FM, Limbourg FP. Multimodal [...] Hypertonie. Ausgewählte Publikationen Richter B*, Kapanadze T*, Weingärtner N, Walter S, Vogt I, Grund A, Schmitz J, Bräsen JH, Limbourg FP, Haffner D, Leifheit-Nestler M. High phosphate-induced progressive [...] . Gamrekelashvili J, Haller H, Limbourg FP. Analysis of Monocyte Cell Fate by Adoptive Transfer in a Murine Model of TLR7-induced Systemic Inflammation. Bio Protoc. 2021 May 5;11(9):e4007. doi: 10.217

Local ABC-HCC A Phase IIIb, randomized, multicenter, open-label trial of Atezolizumab plus Bevacizumab versus trans arterial Chemoembolization (TACE) in intermediate-stage HCC IMMUWIN A phase II study [...] Subjects with HER2+ Metastatic Colorectal cancer Gallengangs- bzw. Cholangiokarzinom Lokal IMMUWHY A phase II study of immunotherapy with durvalumab (MEDI4736) or durvalumab and tremelimumab, both combined [...] ablation via catheter and transpapillary access in patients with cholangiocarcinoma (ACTICCA-2 trial) . A randomized, open-label investigator-initiated trial Clean-Duct/ TRITICC-3 Phase IIa, prospective, single

maintaining the barrier, utilizing both intestinal organoids and a "Gut-on-a-Chip" system. Topic: Stromal Cell Immunity The mesenteric lymph nodes play a pivotal role in the intestinal immune system as they determine [...] this complexity poses a challenge for both the innate and adaptive immune systems. It is crucial for the immune defense system to combat pathogens while maintaining tolerance to a variety of antigens. Failure [...] various cell types present in mucosal tissues at cellular and molecular levels. Topic: Barrier Integrity A central focus of our work lies on the intestinal barrier, consisting of various epithelial cell populations

ede M, Ulas T, von Kaisenberg CS, Roth J, Vogl T, Viemann D. In neonates S100A8/S100A9 alarmins prevent the expansion of a specific inflammatory monocyte population promoting septic shock. FASEB J.31:1153-1164 [...] Bertheloot D, Freise N, Spiekermann C, Witten A, Viemann D, Kirschnek S, Stoll M, Latz E, Schultze JL, Roth J, Vogl T. Transcriptome Assessment Reveals a Dominant Role for TLR4 in the Activation of Human [...] Viemann D, Schmolke M, Lueken A, Boergeling Y, Friesenhagen J, Wittkowski H, Ludwig S, Roth J. H5N1 virus activates signaling pathways in human endothelial cells resulting in a specific imbalanced inflammatory

ability of conditioned stimuli to affect instrumental responding is a robust finding from animal as well as human research and is considered a key factor for the development and maintenance of addictive behaviors [...] shopping: A pilot study with eye tracking Patients suffering from addictive disorders tend to notice stimuli associated with their addition faster than individuals without the disorder. The study uses a grid [...] including those with compulsive buying-shopping disorder or social network use disorder. There is a lack of research considering stress and its impact on affective and cognitive mechanisms in both in