Meier working group
Small animal imaging has established itself as an important tool in preclinical research. Nevertheless, the results of non-invasive imaging are often disappointing due to a suboptimal selection of imaging techniques or deficiencies in study design, experimental setup or data analysis.
Research is therefore focused on the areas mentioned above with a view to standardizing small animal imaging methods.
In addition, the work focuses on the special handling of animals for imaging and the economic management of the small animal imaging center.
Calibration procedures, data post-processing and special imaging applications for various models of human diseases are further focal points of the research activities. His own research interests include cardiovascular applications, monitoring of implants, lung imaging and physiological, spectroscopic applications.
(Dr. Martin Meier, AG management)
Baraki H, Zinne N, Wedekind D, Meier M, Bleich A, Glage S, Hedrich HJ, Kutschka I, Haverich A.
Magnetic resonance imaging of soft tissue infection with iron oxide labeled granulocytes in a rat model. PLoS One. 2012;7(12):e51770. doi: 10.1371/journal.pone.0051770. Epub 2012 Dec 7. PubMed PMID: 23236524; PubMed Central PMCID: PMC3517554.
Sterenczak KA, Meier M, Glage S, Meyer M, Willenbrock S, Wefstaedt P, Dorsch M, Bullerdiek J, Murua Escobar H, Hedrich H, Nolte I.
Longitudinal MRI contrast enhanced monitoring of early tumor development with manganese chloride (MnCl2) and superparamagnetic iron oxide nanoparticles (SPIOs) in a CT1258 based in vivo model of prostate cancer.
BMC Cancer. 2012 Jul 11;12:284. PubMed PMID: 22784304; PubMed Central PMCID: PMC3520113.
Michael S, Keubler LM, Smoczek A, Meier M, Gunzer F, Pöhlmann C, Krause-Buchholz U, Hedrich HJ, Bleich A.
Quantitative phenotyping of inflammatory bowel disease in the IL-10-deficient mouse by use of noninvasive magnetic resonance imaging.
Inflamm Bowel Dis. 2013 Jan;19(1):185-93. doi: 10.1002/ibd.23006. PubMed PMID: 22570250.
Sommer T, Meier M, Bruns F, Pabst R, Breves G, Hadamitzky C.
Quantification of lymphedema in a rat model by 3D-active contour segmentation by magnetic resonance imaging.
Lymphat Res Biol. 2012 Mar;10(1):25-9. doi: 10.1089/lrb.2011.0010. Epub 2012 Mar 14. PubMed PMID: 22416909.
Willenbrock S, Knippenberg S, Meier M, Hass R, Wefstaedt P, Nolte I, Murua Escobar H, Petri S.
In vivo MRI of intraspinally injected SPIO-labeled human CD34+ cells in a transgenic mouse model of ALS.
In Vivo. 2012 Jan-Feb;26(1):31-8. PubMed PMID: 22210713.
Lu X, Li N, Shushakova N, Schmitt R, Menne J, Susnik N, Meier M, Leitges M, Haller H, Gueler F, Rong S.
C57BL/6 and 129/Sv mice: genetic difference to renal ischemia-reperfusion.
J Nephrol. 2012 Sep-Oct;25(5):738-43. doi: 10.5301/jn.5000053. PubMed PMID: 22180224.