Wedekind working group

The research focus of the working group is the LEW.1AR1-iddm rat, an animal model for type 1 diabetes mellitus (T1D).

The research group is also investigating the LEW-Myo15ci2/Ztm rat, whose symptoms are similar to Usher syndrome in humans (USH).

A recently identified mutation in the Dnd1 gene, which leads to the development of teratocarcinoma, is also a focus of the working group. Interestingly, the genetic environment of the mutation influences carcinogenesis and determines the sex specificity of the tumor.

• Mmp3
  The project is a cooperation with the University of Bremen.
  Funding: EU.

In addition, the Genetic Diagnostics working group is involved in numerous collaborations with other working groups at the MHH.

• Complete list of publications as pdf
• Selected publications

Arndt, T., Jörns, A., Weiss, H., Tiedge, M., Hedrich, H. J., Lenzen, S. and Wedekind, D. (2013)
A variable CD3⁺ T-cell frequency in peripheral blood lymphocytes associated with type 1 diabetes mellitus development in the LEW.1AR1-iddm rat. PLoS
One. 8, e64305

Baehr, I., Bazwinsky-Wutschke, I., Wolgast, S., Hofmann, K., Streck, S., Muehlbauer, E., Wedekind, D. and Peschke, E. (2012)
GLUT4 in the Endocrine Pancreas - Indicating an Impact in Pancreatic Islet Cell Physiology?
Hormone and Metabolic Research. 44, 442-450

Baraki, H., Zinne, N., Wedekind, D. Meier, M., Bleich, A., Glage, S., Hedrich, H.-J., Kutschka, I. and Haverich, A. (2012)
Magnetic resonance imaging of soft tissue infection with iron oxide labeled granulocytes in a rat model.
PloS one. 7, e51770-e51770

Elsner, M., Terbish, T., Joerns, A., Naujok, O., Wedekind, D. Hedrich, H.-J. and Lenzen, S. (2012)
Reversal of Diabetes Through Gene Therapy of Diabetic Rats by Hepatic Insulin Expression via Lentiviral Transduction.
Molecular Therapy. 20, 918-926