Advanced module Fundamentals of surgical work in laboratory animal science

The course is aimed at scientists with a degree and technical staff who wish to carry out surgical procedures as part of animal experiments.

The basic techniques of surgical work are taught. As part of the advanced module, an operation is first performed on a dead animal and in the second part on a live animal under injection anesthesia.

Prerequisite for participation:

• successful participation in the lecture series "Fundamentals of Laboratory Animal Science" and participation in the basic module "Animal Experimental Techniques"
• planned participation in a surgical procedure as part of an animal experiment at the ZTL (application in progress at the ZTL or indication of the file number)

Number of participants:

• A maximum of 4 participants as part of the biomedicine master's course,
• if more than 8 participants are interested, an additional date will be offered

Contact: Dr. Miriam Heider (8492) or Dr. Regina Rumpel (3939)

Date: on request

Location: Course room of the Central Animal Laboratory, Building I-5, Level 03, Room 1420

Registration: by email to Heider.Miriam@mh-hannover.de and Rumpel.Regina@mh-hannover.de

Evaluation of the exposure of animals in experiments

The module sets out the legal and ethical requirements for the necessity of evaluating the exposure of animals in experiments. Species-specific signs of pain are presented.

Scores are used to show how "humane endpoints" are defined and instructions for the persons responsible for the care of animals in experiments are drawn up. Stress assessments are carried out in small groups using examples and then discussed with the whole group.

Prerequisite for participation: successful participation in the lecture series "Fundamentals of Laboratory Animal Science" and participation in the basic module "Animal Experimental Techniques"

Number of participants: the number of participants is limited. The module will only take place with a minimum of 10 participants.

Contact: Dr. Christine Häger

Date: 07.11.2024 9 am - 1 pm (ENGLISH) FULL; 14.11.2024 9 am - 1 pm (GERMAN) FULL

Location: Course room of the Central Animal Laboratory, Building I-5, Level 03, Room 1420

Registration: Please send a request by email to Haeger.Christine@mh-hannover.de

Application for animal testing projects

In this module, the legal basis for applying for animal experiments and interventions on animals for scientific purposes is taught and discussed in a user-oriented and practical way using examples.

Tips and assistance are provided on important application points such as statistics, experiment description, scoring or pain management and the use of medication, which should support the preparation of an initial application or help with the optimization of subsequent applications.

Prerequisites for participation: none

Number of participants: unlimited

Contact: Dr. Nadine Held

Date: on request

Location: online (via Teams by invitation)

Registration: by email to held.nadine@mh-hannover.de ;

Statistics and biometric methods in laboratory animal science (Statistics I)

Statistics and biometric methods in laboratory animal science (Statistics I)
This basic course is aimed at anyone (Master's students, PhD students and scientists etc.) who would like to gain an initial overview of practically applied statistics/biometrics, e.g. in the context of laboratory animal science.

• general statistics/biometrics
• descriptive & inferential statistics
• Data and data types
• Introduction to experimental design/experimental planning
• General evaluations: statistical tests & procedures
• practical exercises in GraphPad Prism

Prerequisites for participation: If possible, please bring your own laptops with pre-installed GraphPad Prism software (versions 5/6 or 7). Licenses cannot be provided

Number of participants: 10-15

Contact person: Dr. Steven R. Talbot

Date: April 08, 2024 & September 16, 2024, 09:00-12:00 each day

Location: Will be announced when the minimum number of participants is reached

Registration: by email by April 01, 2024 or September 09, 2024 to talbot.steven@mh-hannover.de

Advanced module Nomenclature, genetics and breeding of laboratory rodents

The aim of the advanced module is

• to enable participants to use the basic rules of nomenclature of mouse and rat strains safely in everyday life. Participants will use examples to name and identify strains.
• Teach participants how to use coat colors and coat color variants for quality control of their laboratory rodents
• teach participants the basics of breeding planning in order to be able to calculate animal numbers and cage quotas

Prerequisite for participation:

• Successful participation in the lecture series "Fundamentals of Laboratory Animal Science" and participation in the basic module "Animal Experimental Techniques"

Number of participants:

• 3-20 persons (minimum number of participants is three)

Contact: Dirk Wedekind

Date: Date by arrangement with the participants

Location: Course room level 3 in the ZTL

Registration: ZTL office

Biological standardization of laboratory animals and organization of laboratory animal facilities

The number of animals required to achieve an experimental objective must be limited to the absolute minimum. At the same time, the test results must be valid and reproducible. In order to ensure this, the group of animals to be examined should exhibit as little variability as possible - i.e. be "standardized".

The module presents possibilities for the standardization of laboratory animals. The organization of laboratory animal facilities should ensure that standardization measures are maintained. After a theoretical introduction, a tour of the ZTL will show how this is implemented at the Central Animal Laboratory of the Medical School (ZTL).

Prerequisite for participation:

• Successful participation in the lecture series "Fundamentals of Laboratory Animal Science" and participation in the basic module "Animal Experimental Techniques (or equivalent)

Number of participants:

• 5 - 10 persons

Contact: For further information please contact PD Dr. Martina Dorsch(dorsch.martina@mh-hannover.de)

Date: as part of the biomedicine master course (if necessary, an additional date will be offered)

Location: Course room of the Central Animal Laboratory, Building I-5, Level 03, Room 1420

Registration: by e-mail to dorsch.martina@mh-hannover.de

Species-specific expert knowledge course for small ruminants

The course provides basic knowledge of the biology/physiology/anatomy, the most important diseases and special legal requirements (e.g. animal disease legislation) of sheep and goats. In addition, practical aspects of handling pre- and post-operative animals and stress assessment are covered.
The course is accepted by the authorities as an animal species-specific specialist course for the animal species "small ruminants".

Prerequisite for participation:

• successful participation in the lecture series "Fundamentals of Laboratory Animal Science" and participation in the basic module "Animal Experimental Techniques"
• planned collaboration on an animal experiment application for sheep/goats (application in progress at the ZTL or indication of the file number)

Number of participants: 1 to 5 persons

Contact: Dr. Regina Rumpel or Lena Brix

Date: Dates on request

Location: ZTL large animal husbandry, meeting at the beginning in the entrance area of the ZTL

Registration: by email to Brix.Lena@mh-hannover.de or rumpel.regina@mh-hannover.de

Species-specific expert training course for pigs

The course provides basic knowledge of the biology/physiology/anatomy, the most important diseases and special legal requirements (e.g. animal disease legislation) of pigs. In addition, practical aspects of handling pre- and post-operative animals and stress assessment are covered.
The course is accepted by the authorities as a species-specific specialist course for the animal species "pig".

Prerequisite for participation:

• successful participation in the lecture series "Fundamentals of Laboratory Animal Science" and participation in the basic module "Animal Experimental Techniques"
• Planned collaboration on an animal experiment application for pigs (application being processed at the ZTL or indication of the file number)

Number of participants: 1 to 5 people

Contact persons: Lena Brix, Dr. Regina Rumpel

Date: Dates on request

Location: ZTL large animal husbandry, meeting at the beginning in the entrance area of the ZTL

Registration: by email to Brix.Lena@mh-hannover.de or rumpel.regina@mh-hannover.de

Statistical/biometric planning of animal experiments - "Power Course" (Statistics II)

The course is aimed at postdocs and scientists who are writing and/or planning their own TV applications. The course focuses in particular on the requirements that a biometric report must fulfill in order to meet the LAVES requirements and how this can be achieved. Particular attention is paid to the power analysis, the study design and the calculation of sample sizes.

• Biometric reports - what is required?
• Error analysis and exchange of experience
• Communications with the "Office
• Planning of animal experiments and creation of experimental designs
• Power analysis and power calculation
• Statistical and scientific conventions
• practical examples (e.g. in GraphPad Prism and G*Power)

Prerequisite for participation: successful participation in the lecture series "Fundamentals of Laboratory Animal Science", as well as participation in the basic module "Animal Experimental Techniques". An understanding of statistics, e.g. as taught in the course "Statistics and Biometric Methods in Laboratory Animal Science (Statistics I)" or comparable is an advantage.

Note: The GraphPad Prism software may be used for statistics. A license cannot be provided. The program G*Power from the University of Düsseldorf is used to calculate the statistical power. It can be downloaded at the following link: http://gpower.hhu.de/

Number of participants: 10-15

Contact: Dr. Steven R. Talbot

Date: April 15, 2024 & September 23, 2024, 09:00-12:00 each day

Location: Will be announced when the minimum number of participants is reached.

Registration: by email by April 8, 2024 or September 16, 2024 to talbot.steven@mh-hannover.de

Axolotl and other Ambystomatidae in laboratory and veterinary practice

The advanced module (2x4 hours, of which 2x3 hours are theory, 2x1 hour practical) provides an overview of species-appropriate husbandry and breeding, anatomy, diseases, therapy and surgical intervention options. In the practical part, handling and taking smears from axolotls and tiger salamanders are practiced.

Prerequisite for participation: successful participation in the lecture series "Fundamentals of Laboratory Animal Science" and participation in the basic module "Animal Experimental Techniques"

Number of participants: maximum 10

Contact: Dr. Sarah Strauß

Date: on request

Location: Kerstin Reimers Laboratory for Regenerative Biology, Ambystoma Mexicanum Bioregeneration Center

Registration: by email to Dr. Sarah Straußstrauss.sarah@mh-hannover.de

Multi modality in vivo imaging

In the advanced module, various possible applications of the in vivo imaging modalities of the ZTL in animal models of human diseases will be demonstrated. Requirements, limitations and possible combinations of the techniques will be learned using animal-free phantom experiments. The module also includes the evaluation of exemplary data.

Prerequisite for participation:

• Successful participation in the lecture series "Fundamentals of laboratory animal science"
• Participation in the basic module "Animal Experimental Techniques"

Number of participants: 3-5

Contact: Dr. Martin Meier (meier.martin@mh-hannover.de) and Dr. Stefan Lienenklaus (lienenklaus.stefan@mh-hannover.de)

Date: by arrangement

Location: ZTL Imaging Center (I5, level 3)

Registration: by email tomeier.martin@mh-hannover.de

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