PD Dr. Roman Fedorov
Institute for Biophysical Chemistry, OE4350
Hannover Medical School
Office: Building I4, Floor S0, Room 1032
Phone: +49 511 532 3705
Fax: +49 511 532 5966
In our group, we study allosteric mechanisms that regulate enzymatic catalysis in the vital biological processes with the aim to develop new therapies. In different periods, our research areas included structural and mechanistic studies of protein biosynthesis, nitric oxide-based cellular signaling mechanisms, signaling mechanisms of PAS domains, mechanisms of DNA replication, enzymatic mechanisms of sulphotransferases, mechanisms of enzymatic carbohydrate biosynthesis, and mechanisms of innate immunity activation. Currently, our research is focused on molecular mechanisms and specific regulation of nucleotidyltransferases involved in infectious diseases and immunity with the mission to obtain new immunomodulatory agents and anti-infective drugs that do not promote resistance development.