Original publications
Gene Therapy with Voretigene Neparvovec Improves Vision and Partially Restores Electrophysiological Function in Pre-School Children with Leber Congenital Amaurosis.
Gerhardt MJ, Priglinger CS, Rudolph G, Hufendiek K, Framme C, Jägle H, Salchow DJ, Anschütz A, Michalakis S, Priglinger SG.
Biomedicines. 2022 Dec 30;11(1). pii: 103. doi: 10.3390/biomedicines11010103. PubMed [citation] PMID: 36672611, PMCID: PMC9855623
Investigation of Structural Alterations in Inherited Retinal Diseases: A Quantitative SD-OCT-Analysis of Retinal Layer Thicknesses in Light of Underlying Genetic Mutations.
Gersch J, Hufendiek K, Delarocque J, Framme C, Jacobsen C, Stöhr H, Kellner U, Hufendiek K.
Int J Mol Sci. 2022 Dec 16;23(24). pii: 16007. doi: 10.3390/ijms232416007. PubMed [citation] PMID: 36555650, PMCID: PMC9788460
[Pandemic-related sales ban of fireworks in Germany leads to a significant reduction of firework-related eye injuries].
Gabel-Pfisterer A, Böhringer D, Agostini H; Fireworks Injury Study Group.
Ophthalmology. 2022 Dec;119(12):1257-1266. doi: 10.1007/s00347-022-01778-1. Epub 2022 Nov 30. PubMed [citation] PMID: 36449087, PMCID: PMC9713168
MiR-302d inhibits TGFB-induced EMT and promotes MET in primary human RPE cells.
Hu X, Binter M, Hufendiek K, Tode J, Framme C, Fuchs H.
PLoS One. 2022 Nov 28;17(11):e0278158. doi: 10.1371/journal.pone.0278158. eCollection 2022. PubMed [citation] PMID: 36441751, PMCID: PMC9704570
Main Principles of Vitrectomy Using Intraocular Tamponades - A Basic Course in Surgery.
Framme C, Sachs HG, Wachtlin J, Bechrakis NE, Hoerauf H, Gabel VP.
Klin Monbl Augenheilkd. 2022 Nov;239(11):1337-1353. doi: 10.1055/a-1929-9413. Epub 2022 Nov 21. English, German. PubMed [citation] PMID: 36410334, PMCID: PMC9678440
Trigeminal Nerve Affection in Patients with Neuro-Sjögren Detected by Corneal Confocal Microscopy.
Seeliger T, Gehlhaar MA, Oluwatoba-Popoola I, Konen FF, Haar M, Donicova E, Wachsmann M, Pielen A, Gingele S, Prenzler NK, Ernst D, Witte T, Framme C, Bajor A, Skripuletz T.
J Clin Med. 2022 Aug 1;11(15). pii: 4484. doi: 10.3390/jcm11154484. PubMed [citation] PMID: 35956101, PMCID: PMC9369441
Changes in Intraocular Pressure following Narcosis With Medetomidine, Midazolam, and Fentanyl in Association With Initial Intraocular Pressure in Mice.
Binter M, Lüdtke P, Langer F, Schigiel T, Framme C, Heider M, Tode J.
Curr Eye Res. 2022 Nov;47(11):1553-1558. doi: 10.1080/02713683.2022.2101667. Epub 2022 Aug 11. PubMed [citation] PMID: 35943353
[Scientific performance of ophthalmological research institutions in Germany 2018-2020 : Studies, publications, third-party funding and more-The research map of the German Ophthalmological Society (DOG)]
Schaub F, Mele B, Gass P, Ader M, Helbig H, Lagrèze WA, Schlötzer-Schrehardt U, Ueffing M, Cursiefen C; the DOG research map team.
Ophthalmology. 2022 Jun;119(6):582-590. doi: 10.1007/s00347-022-01653-z. Epub 2022 May 23. PubMed [citation] PMID: 35925367
[Economics of operating room use at a university eye hospital]
Framme C, Kuiper T, Lobbes W, Gottschling J, Scheinichen D, Hufendiek K, Palmaers T, Tode J, Volkmann I, Lammert F.
Ophthalmology. 2023 Jan;120(1):7-19. doi: 10.1007/s00347-022-01689-1. Epub 2022 Jul 15. PubMed [citation] PMID: 35925355
Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study.
von der Burchard C, Sudkamp H, Tode J, Ehlken C, Purtskhvanidze K, Moltmann M, Heimes B, Koch P, Münst M, Vom Endt M, Kepp T, Theisen-Kunde D, König I, Hüttmann G, Roider J.
BMJ Open. 2022 Jun 27;12(6):e055082. doi: 10.1136/bmjopen-2021-055082. PubMed [citation] PMID: 35760534, PMCID: PMC9237881
Primary Orbital Reconstruction with Selective Laser Melting (SLM) of Patient-Specific Implants (PSIs): An Overview of 96 Surgically Treated Patients.
Rana M, Moellmann HL, Schorn L, Lommen J, Rana M, Wilkat M, Hufendiek K.
J Clin Med. 2022 Jun 11;11(12). pii: 3361. doi: 10.3390/jcm11123361. PubMed [citation] PMID: 35743432, PMCID: PMC9224837
[The most serious incident-Experiences of aggression and violence in ophthalmology]
Jacobsen C, Volkmann I, Wedegärtner F, Harris J, Bertram B, Bambas B, Framme C.
Ophthalmology. 2022 Sep;119(9):937-944. doi: 10.1007/s00347-022-01634-2. Epub 2022 Apr 20. PubMed [citation] PMID: 35441852, PMCID: PMC9019538
Efficacy, durability, and safety of intravitreal faricimab with extended dosing up to every 16 weeks in patients with diabetic macular oedema (YOSEMITE and RHINE): two randomized, double-masked, phase 3 trials.
Wykoff CC, Abreu F, Adamis AP, Basu K, Eichenbaum DA, Haskova Z, Lin H, Loewenstein A, Mohan S, Pearce IA, Sakamoto T, Schlottmann PG, Silverman D, Sun JK, Wells JA, Willis JR, Tadayoni R; YOSEMITE and RHINE Investigators.
Lancet. 2022 Feb 19;399(10326):741-755. doi: 10.1016/S0140-6736(22)00018-6. Epub 2022 Jan 24. PubMed [citation] PMID: 35085503
[Regression of idiopathic epiretinal membrane-Case report and consideration of the possible mechanism].
Framme C, Feltgen N, Schumann R, Stichtenoth DO, Hattenbach LO.
Ophthalmology. 2022 Aug;119(8):801-806. doi: 10.1007/s00347-022-01577-8. Epub 2022 Jan 25. review. German. PubMed [citation] PMID: 35076756
[Avoiding mistakes in anti-VEGF intravitreal injection therapy]
Framme C, Junker B, Feltgen N, Hoerauf H, Striebe NA, Wachtlin J, Volkmann I.
Ophthalmologe. 2022 Mar;119(3):309-326. doi: 10.1007/s00347-021-01553-8. Epub 2022 Jan 14. PubMed [citation] PMID: 35029746
The influence of corneal density and thickness on tonometry measurement with goldmann applanation, non-contact and iCare tonometry methods.
Lubbad A, Oluwatoba-Popoola I, Haar M, Framme C, Bajor A.
Int Ophthalmol. 2022 Jul;42(7):2167-2174. doi: 10.1007/s10792-022-02216-6. Epub 2022 Jan 13. PubMed [citation] PMID: 35023013, PMCID: PMC9287215
Algorithms for optoacoustically controlled selective retina therapy (SRT)
Seifert E, Tode J, Pielen A, Theisen-Kunde D, Framme C, Roider J, Miura Y, Birngruber R, Brinkmann R.
Photoacoustics. 2021 Nov 10;25:100316. doi: 10.1016/j.pacs.2021.100316. eCollection 2022 Mar. PubMed [citation] PMID: 34926158, PMCID: PMC8649889
[Epidemiology and treatment of retinopathy of prematurity. The Hannover data in the Retina.net ROP registry from 2001-2017].
Akman SH, Pfeil JM, Stahl A, Ehlers S, Böhne C, Bohnhorst B, Framme C, Brockmann D, Bajor A, Jacobsen C, Hufendiek K, Pielen A; Retina.net ROP registry study group.
Ophthalmologist. 2022 May;119(5):497-505. doi: 10.1007/s00347-021-01528-9. Epub 2021 Nov 22. PubMed [citation] PMID: 34811591, PMCID: PMC9076709
[Performance and cost calculation for a university ophthalmological outpatient clinic]
Framme C, Dittberner M, Rohwer-Mensching K, Gottschling J, Buley P, Hufendiek K, Hufendiek K, Junker B, Tode J, Lammert F, Volkmann I.
Ophthalmologe. 2022 Jan;119(1):46-54. doi: 10.1007/s00347-021-01529-8. Epub 2021 Nov 20. PubMed [citation] PMID: 34802069, PMCID: PMC8605894
Measurement of tear resistance after manual capsulorhexis and femtosecond laser-assisted capsulotomy of crystalline lenses.
Patzlaff-Günther M, Fromm M, Kern T, Bartram M, Schwäblein A, Heinemann D, Johannsmeier S, Framme C, Ripken T.
Lasers Med Sci. 2022 Apr;37(3):1891-1897. doi: 10.1007/s10103-021-03448-1. Epub 2021 Oct 29. PubMed [citation] PMID: 34713366, PMCID: PMC8971170
[Atypical clinical course of a freshly perforated corneal ulcer]
Sinicin E, Brockmann D, Bartram M, Framme C, Bajor A.
Ophthalmologe. 2022 May;119(5):509-511. doi: 10.1007/s00347-021-01381-w. Epub 2021 Apr 19. German. No abstract available. PubMed [citation] PMID: 33876271, PMCID: PMC9076731
Other activities in research
Framme, Carsten (Prof. Dr. med., MBA): Member of the editorial board of the journal Der Ophthalmologe; member of the scientific advisory board of the journal Klinische Monatsblätter für Augenheilkunde.
Pielen, Amelie (PD Dr. med.): Associate Editor of Acta Ophthalmologica; Member of the Clinical Trials Working Group
Accepted congress contributions (abstracts)
ARVO 2022
120th Annual Meeting of the German Ophthalmological Society 2022
Original publications
The microRNAs miR-302d and miR-93 inhibit TGFB-mediated EMT and VEGFA secretion from ARPE-19 cells.
Fuchs HR, Meister R, Lotke R, Framme C.
Exp Eye Res. 2020 Sep 25;201:108258. https://doi.org/10.1016/j.exer.2020.108258
[Cost unit accounting of strabismus surgery at a university eye hospital].
Framme C, Gottschling J, Kuiper T, Lobbes W, Palmaers T, Brockmann D, Lagrèze WA, Hufendiek K.
Ophthalmologe. 2020 Oct;117(10):1006-1014. https://doi.org/10.1007/s00347-020-01227-x
Importance of continuous treatment with intravitreal aflibercept injections in patients with neovascular age-related macular degeneration-12-month post hoc analysis of the PERSEUS real-world evidence study.
Wachtlin J, Eter N, Hasanbasic Z, Keramas G, Rech C, Sachs H, Schilling H, Wiedemann P, Framme C.
Graefes Arch Clin Exp Ophthalmol. 2020 Aug 13. https://doi.org/10.1007/s00417-020-04803-8
[Current situation of allocation of academic medical personnel in ophthalmology departments in Germany].
Schargus M, Wachtlin J, Aisenbrey S, Blum M, Framme C, Hattenbach LO, Hoerauf H, Kaskel-Paul S, Geerling G.
Ophthalmologe. 2020 Sep;117(9):905-913. https://doi.org/10.1007/s00347-020-01203-5
Comparison of Macular Pigment Optical Density in Glaucoma Patients and Healthy Subjects - A Prospective Diagnostic Study.
Bruns Y, Junker B, Boehringer D, Framme C, Pielen A.
Clin Ophthalmol. 2020 Apr 1;14:1011-1017. https://doi.org/10.2147/OPTH.S224259
Neuroprotection with rasagiline in patients with macula-off retinal detachment: A randomized controlled pilot study.
Yu S, Framme C, Menke MN, Berger LE, Zinkernagel MS, Munk MR, Wolf S, Ebneter A.
Sci Rep. 2020 Mar 18;10(1):4948. https://doi.org/10.1038/s41598-020-61835-0
[Retinal laser treatment-avoiding mistakes].
Framme C, Hoerauf H, Wachtlin J, Volkmann I, Bartram M, Junker B, Feltgen N.
Ophthalmologe. 2020 Feb;117(2):169-188. https://doi.org/10.1007/s00347-019-01035-y
[Experiences of aggression and violence against ophthalmologists].
Jacobsen C, Volkmann I, Wedegärtner F, Harris J, Bertram B, Gass P, Bambas B, Framme C.
Ophthalmologist. 2020 Aug;117(8):775-785. https://doi.org/10.1007/s00347-020-01039-z
Individualized treat-and-extend regime for optimization of real-world vision outcome and improved patients' persistence.
Volkmann I, Knoll K, Wiezorrek M, Greb O, Framme C.
BMC Ophthalmol. 2020 Mar 30;20(1):122. https://doi.org/10.1186/s12886-020-01397-x
Modulation of inflammatory processes by thermal stimulating and RPE regenerative laser therapies in age related macular degeneration mouse models
Elisabeth Richert, Claus von der Burchard, Alexa Klettner, Philipp Arnold, Ralph Lucius, Ralf Brinkmann, Johann Roider, Jan Tode
Cytokine: X 2 (2020) 100031; https://doi.org/10.1016/j.cytox.2020.100031
Response of Retinal Pigment Epithelium (RPE)-Choroid Explants to Thermal Stimulation Therapy of the RPE (TSR).
Richert E, Papenkort J, Klettner A, Tode J, Koinzer S, Brinkmann R, Fink C, Roeder T, Lucius R, Roider
J.Lasers Surg Med. 2020 Jun 21. https://doi.org/10.1002/lsm.23288
Emulsified silicone oil is taken up by and induces pro-inflammatory response in primary retinal microglia.
Klettner A, Harms A, Waetzig V, Tode J, Purtskhvanidze K, Roider J.
Graefes Arch Clin Exp Ophthalmol. 2020 Sep;258(9):1965-1974. https://doi.org/10.1002/lsm.2328810.1007/s00417-020-04763-z
CRB1rd8 mutation influences the age-related macular degeneration phenotype of NRF2 knockout mice and favors choroidal neovascularization.
Richert E, Klettner A, von der Burchard C, Roider J, Tode J.
Adv Med Sci. 2020 Mar;65(1):71-77. https://doi.org/10.1016/j.advms.2019.11.003
[Effect of Selective Retina Therapy (SRT) on the Inflammatory Microenvironment of the Subretinal Space].
Richert E, Bartsch S, Hillenkamp J, Treumer F, Tode J, von der Burchard C, Brinkmann R, Klettner AK, Roider J.
Klin Monbl Augenheilkd. 2020 Feb;237(2):192-201. https://doi.org/10.1055/a-0838-5633
Other activities in research
Framme, Carsten (Prof. Dr. med., MBA): Member of the editorial board of the journal Der Ophthalmologe; member of the scientific advisory board of the journal Klinische Monatsblätter für Augenheilkunde.
Pielen, Amelie (PD Dr. med.): Associate Editor of Acta Ophthalmologica; Member of the Clinical Trials Working Group
Accepted congress contributions (abstracts)
ARVO 2020, digital
Inflammatory Processes Following Thermal Stimulation of the Retina (TSR) and Selective Retina Therapy (SRT) in AMD Mouse Models
Jan Tode; Elisabeth Richert; Claus von der Burchard; Ralf Brinkmann; Alexa Klettner; Johann Roider
Investigative Ophthalmology & Visual Science June 2020, Vol.61, 1352.
118th Annual Meeting of the German Ophthalmological Society 2020, digital
Alagille syndrome with JAG1 mutation: Ophthalmologic features
Jacobsen C.*, Haar M., Bartram M., Framme C., Hufendiek K.
Ophthalmologe 2020 - 117 (Suppl 2):S43-S190; https://doi.org/10.1007/s00347-020-01197-0
Bilateral-simultaneous isolated non-Hodgkin's lymphoma of the conjunctiva
Sinicin E.*, Bartram M., Heuser M., Framme C., Hufendiek K.
Ophthalmologe 2020 - 117 (Suppl 2):S43-S190; https://doi.org/10.1007/s00347-020-01197-0
Sphere in the eye
Haar M.*, Luger B., Akman S., Lubbad A., Kern T., Abou Moulig W., Framme C., Hufendiek K., Pielen A.
Ophthalmologe 2020 - 117 (Suppl 2):S43-S190; https://doi.org/10.1007/s00347-020-01197-0
Ocular involvement in systemic ATTR amyloidosis with a p.V50M mutation
Lubbad A.*, Lüdtke P., Bräsen J. H., Framme C., Pielen A., Tode J.
Ophthalmologe 2020 - 117 (Suppl 2):S43-S190; https://doi.org/10.1007/s00347-020-01197-0
Background: We report a case of simultaneous bilateral central retinal vein occlusions (CRVO) in a 25-year-old man as a first manifestation of chronic myeloid leukemia (CML)
Lüdtke P.*, Thol F., Glowacka I., Hufendiek K., Pielen A., Junker B., Framme C., Hufendiek K.
Ophthalmologe 2020 - 117 (Suppl 2):S43-S190; https://doi.org/10.1007/s00347-020-01197-0
Do SRT laser lesions induce RPE atrophy in the long term? Investigation of fundus autofluorescence up to 2 years after selective retinal therapy (SRT) in patients with refractory persistent acute chorioretinopathia centralis serosa (CCS)
Rosenstein C.*, Jacobsen C., Büttner M., Danzmann L., Luger B., Volkmann I., Tode J., Junker B., Framme C., Pielen A., SRT Study Group
Ophthalmologe 2020 - 117 (Suppl 2):S43-S190; https://doi.org/10.1007/s00347-020-01197-0
Treat and Extend for success: Real world two-year data on intravitreal injection therapy for diabetic macular edema
Volkmann I.*, Sagurski N., Pielen A., Framme C., Tode J., IVOM-TE study group
Ophthalmologe 2020 - 117 (Suppl 2):S43-S190; https://doi.org/10.1007/s00347-020-01197-0
Inflammatory processes after thermal stimulation of the retina (TSR) and selective retinal therapy (SRT) in the AMD mouse model
Tode J.*, Richert E., von der Burchard C., Klettner A., Brinkmann R., Roider J.
Ophthalmologe 2020 - 117 (Suppl 2):S43-S190; https://doi.org/10.1007/s00347-020-01197-
Original publications
Time recording in ophthalmologic clinical trials. A multicenter field study
Bohringer D, Goos D, Ach T, Feltgen N, Fleckenstein M, Kohnen T, Lorenz K, Pielen A, Spital G, Wilhelm B, Bohringer S, Reinhard T, Arbeitsgemeinschaft DOG - Klinische Studienzentren.
Ophthalmologist 2019;116(9):872-878; Full text: http://dx.doi.org/10.1007/s00347-019-0851-0
Assessment of ophthalmology student teaching - results of a survey at German universities.
DOG working group on teaching, group of ophthalmology lecturers in Germany, Feltgen N.
Ophthalmologe 2019; full text: https://doi.org/10.1007/s00347-019-00984-8
The flicker response of venous oxygen saturation is significantly reduced in the early and late stages of age-related macular degeneration.
Donicova E, Ramm L, Augsten R, Hammer M.
Graefes Arch Clin Exp Ophthalmol 2019; full text: https://doi.org/10.1007/s00417-019-04533-6
Ipsilateral transient amaurosis, mydriasis and light reflex absence after subconjunctival local anesthesia with mepivacaine in three patients with refractory glaucoma - a case report
Knoll K, Chobanyan-Jürgens K, Stichtenoth DO, Volkmann IR, Hufendiek K, Framme C.
BMC Ophthalmol 2019;19(1):195; full text: https://doi.org/10.1186/s12886-019-1202-2
How and why SGLT2 inhibitors should be explored as potential treatment option in diabetic retinopathy: clinical concept and methodology.
May M, Framke T, Junker B, Framme C, Pielen A, Schindler C.
Therapeutic advances in endocrinology and metabolism 2019;10; Full text: https://doi.org/10.1177/2042018819891886
Ranibizumab Pro Re nata versus Dexamethasone in the Management of Ischemic Retinal Vein Occlusion: Post-hoc Analysis from the COMRADE Trials
Pielen A, Feltgen N, Hattenbach LO, Hoerauf H, Bertelmann T, Quiering C, Vögeler J, Priglinger S, Lang GE, Schmitz-Valckenberg S, Wolf A, Rehak M.
Curr Eye Res 2019:1-11; full text: https://doi.org/10.1080/02713683.2019.1679839
Dissertations
Greb, Oliver (Dr. med.): Electronic visualization of outpatient patient flow in a university eye clinic. - 47 sheets, 10 uncounted sheets : diagrams
Cumulative dissertation, Hannover Medical School, 2019
Full text: https: //doi.org/10.26068/mhhrpm/20191018-003
Further activities in research
Framme, Carsten (Prof. Dr. med., MBA): Member of the editorial board of the journal Der Ophthalmologe; member of the scientific advisory board of the journal Klinische Monatsblätter für Augenheilkunde.
Pielen, Amelie (PD Dr. med.): Associate Editor of Acta Ophthalmologica; Member of the Clinical Trials Working Group
Accepted congress contributions (abstracts)
117th Annual Meeting of the German Ophthalmological Society 2019 in Berlin
Experiences of aggression and violence among ophthalmologists - A survey by BVA and DOG
Jacobsen C.*, Volkmann I., Wedegärtner F., Harris J., Bertram B., Gass P., Bambas B., Framme C.
Ophthalmologe 2019 ・ 116 (Suppl 2):S25-S218; https:// doi.org/ 10.1007/ s00347- 019- 0940-0
Comparison of reproducibility using two types of SPECTRALIS® Spectral Domain Optical Coherence Tomography devices in glaucoma diagnostics
Höhmann K.*, Framme C., Volkmann I.
Ophthalmologe 2019 ・ 116 (Suppl 2):S25-S218; https:// doi.org/ 10.1007/ s00347- 019- 0940-0
Unusual ophthalmic infarction in a young woman
Doničová E.*, Junker B., Framme C., Bajor A., Hufendiek K.
Ophthalmologist 2019 ・ 116 (Suppl 2):S25-S218; https:// doi.org/ 10.1007/ s00347- 019- 0940-0
Real world two-year data on intravitreal injection therapy for exudative AMD
Volkmann I.*, Sagurski N., Framme C.
Ophthalmologe 2019 ・ 116 (Suppl 2):S25-S218; https:// doi.org/ 10.1007/ s00347- 019- 0940-0
SD-OCT monitoring and visual acuity progression in patients with refractory persistent acute chorioretinopathia centralis serosa (CCS) after selective retinal therapy (SRT)
Luger B.*, Büttner M., Abou Moulig W., Junker B., Framme C., Pielen A.
Ophthalmologe 2019 ・ 116 (Suppl 2):S25-S218; https:// doi.org/ 10.1007/ s00347- 019- 0940-0
The microRNAs miR-199 and miR-17 inhibit TGFB-induced epithelial to mesenchymal transition of ARPE-19 cells
Fuchs H.*, Framme C.
Ophthalmologe 2019 ・ 116 (Suppl 2):S25-S218; https:// doi.org/ 10.1007/ s00347- 019- 0940-0
First description of two cases of unilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE) treated with plasmapheresis
Rosenstein C.*, Wagner A., Framme C., Hufendiek K.
Ophthalmologist 2019 ・ 116 (Suppl 2):S25-S218; https:// doi.org/ 10.1007/ s00347- 019- 0940-0
Endophthalmitis - Clinically atypical course of advanced endophthalmitis with perforated corneal ulcer
Sinicin E.*, Brockmann D., Bartram M., Framme C., Bajor A.
Ophthalmologe 2019 ・ 116 (Suppl 2):S25-S218; https:// doi.org/ 10.1007/ s00347- 019- 0940-0
Initial manifestation of a sphenoid wing meningioma
Gehlhaar M. A.*, Spalthoff S., Hermann E., Framme C., Hufendiek K.
Ophthalmologe 2019 ・ 116 (Suppl 2):S25-S218; https:// doi.org/ 10.1007/ s00347- 019- 0940-0
Original publications
Supplementary statement of the BVA, the DOG and the RG on laser therapy of glands in age-related macular degeneration (AMD): As of October 2018
Berufsverband der Augenarzte Deutschlands e.V. (BVA), Deutsche Ophthalmologische Gesellschaft (DOG), Retinologische Gesellschaft e.V. (RG).
Ophthalmologist 2019;116(2):138-143; Full text: http://dx.doi.org/10.1007/s00347-018-0834-6
Optical coherence tomography angiography analysis of macular flow density in glaucoma.
Kromer R, Glusa P, Framme C, Pielen A, Junker B.
Acta Ophthalmol 2019;97(2):e199-e206; Full text: http://dx.doi.org/10.1111/aos.13914
Vitrectomy with and without encircling band for pseudophakic retinal detachment with inferior breaks: VIPER Study Report No. 3.
Baumgarten S, Schiller P, Hellmich M, Walter P, Agostini H, Junker B, Helbig H, Lommatzsch A, Mazinani B, VIPER Study Group.
Graefes Arch Clin Exp Ophthalmol 2018;256(11):2069-2073; Full text: http://dx.doi.org/10.1007/s00417-018-4106-6
Comparison of ranibizumab versus dexamethasone for macular oedema following retinal vein occlusion: 1-year results of the COMRADE extension study.
Feltgen N, Hattenbach LO, Bertelmann T, Callizo J, Rehak M, Wolf A, Berk H, Eter N, Lang GE, Pielen A, Schmitz-Valckenberg S, Quiering C, Rose U, Hoerauf H, COMRADE Study Group.
Acta Ophthalmol 2018;96(8):e933-e941; Full text: http://dx.doi.org/10.1111/aos.13770
Ocular Blood Volume Index Based on Scattering Properties of Retinal Vessels Using Spectral Domain Optical Coherence Tomography
Kromer R, Eck B, Rahman S, Framme C.
Curr Eye Res 2018:1-7; full text: http://dx.doi.org/10.1080/02713683.2018.1527367
Trajectory-guided biopsy of orbital tumor - Technology, principal considerations and clinical implementation
Rana M, Holtmann H, Lommen J, Rana M, Zeller A, Kübler N, Hufendiek K, Hermann E, Gellrich NC, Sproll C.
J Craniomaxillofac Surg 2018;46(6):994-1000; full text: http://dx.doi.org/10.1016/j.jcms.2018.03.017
Selective retina therapy: towards an optically controlled automatic dosing.
Seifert E, Tode J, Pielen A, Theisen-Kunde D, Framme C, Roider J, Miura Y, Birngruber R, Brinkmann R.
J Biomed Opt 2018;23(11):1-12; full text: http://dx.doi.org/10.1117/1.JBO.23.11.115002
Treated retinopathy of prematurity in Germany : 5-year data from the Retina.net ROP registry.
Walz JM, Bemme S, Reichl S, Akman S, Breuss H, Süsskind D, Glitz B, Müller VC, Wagenfeld L, Gabel-Pfisterer A, Aisenbrey S, Engelmann K, Koutsonas A, Krohne TU, Stahl A, Retina.net ROP Registry Study Group.
Ophthalmologist 2018;115(6):476-488; Full text: dx.doi.org/10.1007/s00347-018-0701-5
Dissertations
Awe, Marita (Dr. med.): Bruch's membrane aperture based minimum rim width : correlation and diagnostic accuracy compared to peripapillary retinal nerve fiber layer thickness. Cumulative dissertation, Hannover Medical School, 2018, MHH-Bibl.-Sig.: D 81176
Habilitations
Pielen, Amelie (PD Dr. med.): Retinal arterial and venous vascular occlusion risk factors and therapeutic options. Cumulative habilitation thesis, Hannover Medical School, 2016
Book contributions
Bornfeld N, Cursiefen C, Framme C, Lagrèze WA [Eds:] Handbook of Ophthalmology 2018/2019 : OphthalmoUpdate 2018. Wiesbaden: med publico GmbH, 2018. 326 pages
Framme C. Diabetic retinopathy (chapter 13). In: Bornfeld N, Cursiefen C, Framme C, Lagrèze WA [Eds]: Handbook of Ophthalmology 2018/2019 : OphthalmoUpdate 2018. Wiesbaden: med publico GmbH, 2018. pp. 1-44
Other activities in research
Framme, Carsten (Prof. Dr. med., MBA): Member of the editorial board of the journal Der Ophthalmologe; member of the scientific advisory board of the journal Klinische Monatsblätter für Augenheilkunde.
Pielen, Amelie (PD Dr. med.): Associate Editor of Acta Ophthalmologica; Member of the Clinical Trials Working Group
Accepted congress contributions (abstracts)
116th Annual Meeting of the German Ophthalmological Society 2018 in Bonn
Individualized treat-and-extend treatment regimen to reduce the frequency of injections and improve patient retention
Volkmann I.*, Höhmann K., Wiezorrek M., Framme C.
Ophthalmologe 2018 - 115(Suppl1):S1-S194; https://doi.org/10.1007/s00347-018-0760-7
Transient amaurosis, mydriasis and limbal pupil after subconjunctival injection of mepivacaine in three patients with chronic glaucoma
Höhmann K.*, Chobanyan-Jürgens K., Stichtenoth D., Hufendiek K., Volkmann I., Framme C.
Ophthalmologe 2018 - 115(Suppl1):S1-S194; https://doi.org/10.1007/s00347-018-0760-7
Ocular side effects under intravenous cidofovir therapy in cytomegalovirus reactivation under immunosuppression
Jacobsen C.*, Park D.-H., Bühler A.-D., Framme C., Hufendiek K.
Ophthalmologe 2018 - 115(Suppl1):S1-S194; https://doi.org/10.1007/s00347-018-0760-7
Bilateral recurrent MOG-IgG-positive autoimmune optic neuritis after stem cell transplantation
Khalili Amiri S.*, Hufendiek K., Skripuletz T., Stadler M., Framme C., Hufendiek K.
Ophthalmologe 2018 - 115(Suppl1):S1-S194; https://doi.org/10.1007/s00347-018-0760-7
4-month analysis of PERSEUS - A prospective non-interventional real-world study on the efficacy of intravitreal aflibercept (IVT-AFL) in patients with neovascular age-related macular degeneration (nAMD) in routine clinical practice
Wachtlin J.*, Eter N., Jochmann C., Keramas G., Sachs H., Schilling H., Wiedemann P., Framme C.
Ophthalmologe 2018 - 115(Suppl1):S1-S194; https://doi.org/10.1007/s00347-018-0760-7
Peripapillary choroidal neovascularization in congestive papilledema
Bajor A.*, Bold S., Framme C., Hufendiek K., Hufendiek K.
Ophthalmologe 2018 - 115(Suppl1):S1-S194; https://doi.org/10.1007/s00347-018-0760-7
SD-OCT monitoring and visual acuity progression in fresh central retinal artery occlusion in the lysis time window
Luger B.*, Weißenborn K., Framme C., Hufendiek K.
Ophthalmologe 2018 - 115(Suppl1):S1-S194; https://doi.org/10.1007/s00347-018-0760-7
Successful LHON therapy for Harding syndrome
Bold S.*, Greb O., Framme C., Hufendiek K.
Ophthalmologe 2018 - 115(Suppl1):S1-S194; https://doi.org/10.1007/s00347-018-0760-7
A rare case of probable Vogt-Koyanagi-Harada Disease Manifestation involving only the eyes
Donicova E.*, Hufendiek K., Junker B., Framme C., Bajor A.
Ophthalmologe 2018 - 115(Suppl1):S1-S194; https://doi.org/10.1007/s00347-018-0760-7
Original publications
Head-to-head comparison of ranibizumab PRN versus single-dose dexamethasone for branch retinal vein occlusion (COMRADE-B)
Hattenbach,L.O.; Feltgen,N.; Bertelmann,T.Schmitz-Valckenberg,S.; Berk,H.; Eter,N.; Lang,G.E.; Rehak,M.; Taylor,S.R.; Wolf,A.; Weiss,C.; Paulus,E.M.; Pielen,A.; Hoerauf,H.; COMRADE-B Study Group.
Acta Ophthalmol, 2018, 96, 1, e10-e18,
Author's reply to comments to: Visual and anatomic outcomes after conversion to aflibercept in neovascular age-related macular degeneration: 12-month results.
Abri Aghdam,K.; Framme,C.; Pielen,A.; Junker
B. Eur.J.Ophthalmol., 2017, 27, 4, e135, Italy
Bruch's membrane opening based minimum rim width : correlation and diagnostic accuracy compared to peripapillary retinal nerve fiber layer thickness.
Awe,M.; Khalili-Amiri,S.; Volkmann,I.R.; Junker,B.; Framme,C.; Hufendiek,K.
Ophthalmologist, 2017, DOI: 10.1007/s00347-017-0616-6, Germany
Retinal vein occlusion - when, with what and how to treat?
Bajor,A.; Pielen,A.; Danzmann,L.
Klin.Monbl Augenheilkd., 2017, 234, 10, 1259-1265, Germany
Statement of the BVA, the DOG and the RG on laser therapy of glands in age-related macular degeneration (AMD) : Status August 2017.
Berufsverband der Augenarzte Deutschlands e.V.; Deutsche Ophthalmologische Gesellschaft; Retinologische Gesellschaft e. V.
Ophthalmologe, 2017, 114, 11, 1008-1014, Germany
Retinal artery occlusion.
Feltgen,N.; Pielen,A.
Ophthalmologist, 2017, 114, 2, 177-190, Germany
Aflibercept for Patients with Neovascular Age-Related Macular Degeneration in Routine Clinical Practice in Germany: Twelve-Month Outcomes of PERSEUS
Framme,C.; Eter,N.Hamacher,T.; Hasanbasic,Z.; Jochmann,C.; Johnson,K.T.; Kahl,M.; Sachs,H.; Schilling,H.; Thelen,U.; Wiedemann,P.; Wachtlin,J.
Ophthalmology Retina, 2017, DOI: 10.1016/j.oret.2017.09.017
Classification and characterization of acute macular neuroretinopathy with spectral domain optical coherence tomography
Hufendiek,K.; Gamulescu,M.A.; Hufendiek,K.; Helbig,H.; Märker,D.
Int.Ophthalmol., 2017, DOI: 10.1007/s10792-017-0742-9, Netherlands
Intraoperative optical coherence tomography and ab interno trabecular meshwork surgery with the Trabectome.
Junker,B.; Jordan,J.F.; Framme,C.; Pielen,A.
Clin.Ophthalmol, 2017, 11, 1755-1760, New Zealand
Intraoperative optical coherence tomography in retinal vitreous surgery. Current experience and outlook on future development steps.
Maier,M.M.; Nasseri,A.; Framme,C.; Bohnacker,S.; Becker,M.D.; Heinrich,D.; Agostini,H.; Feucht,N.; Lohmann,C.P.; Hattenbach,L.O.
Klin.Monbl Augenheilkd., 2017, DOI: 10.1055/s-0043-106304, Germany
Switch of Intravitreal Therapy for Macular Edema Secondary to Retinal Vein Occlusion from Anti-VEGF to Dexamethasone Implant and Vice Versa.
Pielen,A.; Bühler,A.D.; Heinzelmann,S.U.; Böhringer,D.; Ness,T.; Junker,B.
J.Ophthalmol., 2017, 2017, 5831682, United States
Integrated results from the COPERNICUS and GALILEO studies.
Pielen,A.; Clark,W.L.; Boyer,D.S.; Ogura,Y.; Holz,F.G.; Korobelnik,J.F.; Stemper,B.; Asmus,F.; Rittenhouse,K.D.; Ahlers,C.; Vitti,R.; Saroj,N.; Zeitz,O.; Haller,J.A.
Clin.Ophthalmol., 2017, 11, 1533-1540, New Zealand
Predictive factors for functional improvement following intravitreal bevacizumab injections after central retinal vein occlusion
Szurman,G.B.; Meyer,C.H.; Feltgen,N.; Pielen,A.; Spitzer,B.; Rehak,M.; Spital,G.; Dimopoulos,S.; Szurman,P.; Bevacizumab Study Group Venous Occlusion; Januschowski,K.
Graefes Arch.Clin.Exp.Ophthalmol., 2017, 255, 5, 1045-1046, Germany
Case Reports
Diffuse Unilateral Subacute Neuroretinitis Caused by Ancylostoma Hookworm.
Poppert,S.; Heideking,M.; Agostini,H.; Fritzenwanker,M.; Wüppenhorst,N.; Muntau,B.; Henneke,P.; Kern,W.; Krücken,J.; Junker,B.; Hufnagel,M.
Emerg. Infect. Dis., 2017, 23, 2, 343-344, United States
Further activities in research
Framme, Carsten (Prof. Dr. med., MBA): Member of the editorial board of the journal Der Ophthalmologe; member of the scientific advisory board of the journal Klinische Monatsblätter für Augenheilkunde.
Pielen, Amelie (Dr. med.): Associate Editor of Acta Ophthalmologica; Member of the Clinical Trials Working Group.
Original publications
Peripheral retinal non-perfusion and treatment response in branch retinal vein occlusion.
Abri Aghdam K, Reznicek L, Soltan Sanjari M, Framme C, Bajor A, Klingenstein A, Kernt M, Seidensticker F.
Int J Ophthalmol 2016;9(6):858-862
The short-term effects of aflibercept on the size of choroidal neovascularization lesion in treatment-resistant neovascular age-related macular degeneration as determined by spectral-domain optical coherence tomography.
Abri Aghdam K, Seidensticker F, Pielen A, Framme C, Junker B.
Lasers Surg Med 2016;48(7):668-677
Visual and anatomic outcomes after conversion to aflibercept in neovascular age-related macular degeneration: 12-month results.
Aghdam KA, Pielen A, Framme C, Junker B.
Eur J Ophthalmol 2016;26(5):473-478
Listeria monocytogenes endophthalmitis - case report and review of risk factors and treatment outcomes.
Bajor A, Luhr A, Brockmann D, Suerbaum S, Framme C, Sedlacek L.
BMC Infect Dis 2016;16:332
Anti-VEGF Therapy for Retinal Vein Occlusion.
Danzmann LM, Pielen A, Bajor A.
Int J Ophthalmic Res 2016;2(1):110-116
Treatment of optic neuritis with erythropoietin (TONE): a randomized, double-blind, placebo-controlled trial-study protocol.
Diem R, Molnar F, Beisse F, Gross N, Drüschler K, Heinrich SP, Joachimsen L, Rauer S, Pielen A, Sühs KW, Linker RA, Huchzermeyer C, Albrecht P, Hassenstein A, Aktas O, Guthoff T, Tonagel F, Kernstock C, Hartmann K, Kümpfel T, Hein K, van Oterendorp C, Grotejohann B, Ihorst G, Maurer J, Müller M, Volkmann M, Wildemann B, Platten M, Wick W, Heesen C, Schiefer U, Wolf S, Lagreze WA.
BMJ Open 2016;6(3):e010956
Electronic visualization of outpatient flow in a university eye clinic.
Greb O, Abou Moulig W, Hufendiek K, Junker B, Framme C.
Ophthalmologe 2016:DOI: 10.1007/s00347-016-0316-7
Intraoperative real-time OCT in macular surgery.
Hattenbach LO, Framme C, Junker B, Pielen A, Agostini H, Maier M.
Ophthalmologe 2016;113(8):656-662
Clinical Efficacy and Safety of Ranibizumab versus Dexamethasone for Central Retinal Vein Occlusion (COMRADE C): A European Label Study.
Hoerauf H, Feltgen N, Weiss C, Paulus EM, Schmitz-Valckenberg S, Pielen A, Puri P, Berk H, Eter N, Wiedemann P, Lang GE, Rehak M, Wolf A, Bertelmann T, Hattenbach LO, COMRADE-C Study Group.
Am J Ophthalmol 2016;169(258):267
Injection strategies in the use of intravitreal VEGF inhibitors: "Pro Re Nata versus Treat and Extend".
Hufendiek K, Pielen A, Framme C.
Klin Monbl Augenheilkd 2017:DOI: 10.1055/s-0042-122340
Predictive factors for functional improvement following intravitreal bevacizumab injections after central retinal vein occlusion.
Januschowski K, Feltgen N, Pielen A, Spitzer B, Rehak M, Spital G, Dimopoulos S, Bevacizumab Study Group Venous Occlusion, Meyer CH, Szurman GB.
Graefes Arch Clin Exp Ophthalmol 2016:DOI: 10.1007/s00417-016-3471-2
Intraoperative optical coherence tomography in retinal detachment.
Junker B, Maier M, Agostini H, Hattenbach LO, Pielen A, Framme C.
Ophthalmologe 2016;113(8):663-667
Fingolimod Associated Bilateral Cystoid Macular Edema-Wait and See?
Pul R, Osmanovic A, Schmalstieg H, Pielen A, Pars K, Schwenkenbecher P, Sühs KW, Yildiz Ö, Frank B, Stangel M, Skripuletz T.
Int J Mol Sci 2016;17(12):E2106
Injection scheme for intravitreal bevacizumab therapy for macular oedema due to central retinal vein occlusion: results of a multicenter study.
Szurman GB, Januschowski K, Szurman P, Feltgen N, Spitzer B, Pielen A, Rehak M, Spital G, Dimopoulos S, Bevacizumab Study Group Venous Occlusion, Meyer CH.
Acta Ophthalmol 2016:DOI: 10.1111/aos.12976
Vitrectomy with and without encircling band for pseudophakic retinal detachment: VIPER Study Report No 2-main results.
Walter P, Hellmich M, Baumgarten S, Schiller P, Limburg E, Agostini H, Pielen A, Helbig H, Lommatzsch A, Rossler G, Mazinani B, VIPER Study Group.
Br J Ophthalmol 2016:DOI: 10.1136/bjophthalmol-2016-309240
The German ROP Registry: data from 90 infants treated for retinopathy of prematurity.
Walz JM, Bemme S, Pielen A, Aisenbrey S, Breuss H, Alex AF, Wagenfeld L, Schiedel S, Krohne TU, Stahl A, Retina.net ROP Registry.
Acta Ophthalmol 2016;94(8):e744-e752
Adaptive optics assisted and optical coherence tomography guided fs-laser system for ophthalmic surgery in the posterior eye.
Matthias B, Zabic M, Brockmann D, Krüger A, Ripken T.
J Biomed Opt 2016;21(12):121512
Longitudinal time-domain optic coherence study of retinal nerve fiber layer in IFNbeta-treated and untreated multiple sclerosis patients.
Pul R, Saadat M, Morbiducci F, Skripuletz T, Pul Ü, Brockmann D, Sühs KW, Schwenkenbecher P, Kahl KG, Pars K, Stangel M, Trebst C.
Exp Ther Med 2016;12(1):190-200
Case Reports
A little bit of luck in a self-induced penetrating orbital injury.
Bajor A, Calvelli K, Janke E, Bialon P, Lang J, Bültmann E, Brunotte I, Framme C.
Ophthalmologe 2016;113(9):772-774
Orbital complication of acute sinusitis : orbital phlegmon in a 10-year-old child.
Bajor A, Lang CP, Bültmann E, Framme C, Hufendiek K.
Ophthalmologe 2016:DOI: 10.1007/s00347-016-0296-7
Editorials
Cursiefen C, Framme C. Intraoperative OCT technology : Beautiful images or more? Ophthalmologe 2016;113(8):644-645
Book contribution/monograph
Framme C. Myopic macular degeneration and myopic CNV. In: Maier M [ed:] Diagnosis and therapy of pathologic myopia. 2nd, revised edition. Bremen: UNI-MED, 2016. pp. 37-42
Pielen A, Junker B, Feltgen N. Retinal Vein Occlusion. In: Stahl A [ed:] Anti-Angiogenic Therapy in Ophthalmology. Berlin: Springer, 2016. (Essentials in Ophthalmology). S. 131-138
Scholarships
Volkmann, Ingo (Dr. med.): Research grant from the Geschwister Freter Foundation for the project: Identification of microRNAs in vitreous fluid during vitrectomy in patients with amotio retinae or proliferative diabetic retinopathy.
Other research activities
Framme, Carsten (Prof. Dr. med., MBA): Member of the editorial board of the journal Der Ophthalmologe; member of the scientific advisory board of the journal Klinische Monatsblätter für Augenheilkunde.
Pielen, Amelie (Dr. med.): Associate Editor of Acta Ophthalmologica; Member of the Clinical Trials Working Group.
Original publications
Correlation Between Hyperreflective Foci and Clinical Outcomes in Neovascular Age-Related Macular Degeneration After Switching to Aflibercept.
Abri Aghdam K, Pielen A, Framme C, Junker B.
Invest Ophthalmol Vis Sci 2015;56(11):6448-6455
Pinch of luck in a self-induced penetrating orbital injury.
Bajor A, Calvelli K, Janke E, Bialon P, Lang J, Bültmann E, Brunotte I, Framme C.
Ophthalmologe 2016;DOI: 10.1007/s00347-015-0211-7
Cardiovascular Risk Factors in Central Retinal Artery Occlusion: Results of a Prospective and Standardized Medical Examination.
Callizo J, Feltgen N, Pantenburg S, Wolf A, Neubauer AS, Jurklies B, Wachter R, Schmoor C, Schumacher M, Junker B, Pielen A, European Assessment Group for Lysis in the Eye.
Ophthalmology 2015;122(9):1881-1888
Increased expression of angiogenic and inflammatory proteins in the vitreous of patients with ischemic central retinal vein occlusion.
Ehlken C, Grundel B, Michels D, Junker B, Stahl A, Schlunck G, Hansen LL, Feltgen N, Martin G, Agostini HT, Pielen A.
PLoS One 2015;10(5):e0126859
Retinal vein occlusion: epidemiology, classification and clinical findings.
Feltgen N, Pielen A.
Ophthalmologist 2015;112(7):607-620
Selective Retina Therapy in Acute and Chronic-Recurrent Central Serous Chorioretinopathy.
Framme C, Walter A, Berger L, Prahs P, Alt C, Theisen-Kunde D, Kowal J, Brinkmann R.
Ophthalmologica 2015;234(4):177-188
TREAT-AND-EXTEND REGIMENS WITH ANTI-VEGF AGENTS IN RETINAL DISEASES: A Literature Review and Consensus Recommendations.
Freund KB, Korobelnik JF, Devenyi R, Framme C, Galic J, Herbert E, Hoerauf H, Lanzetta P, Michels S, Mitchell P, Mones J, Regillo C, Tadayoni R, Talks J, Wolf S.
Retina 2015;35(8):1489-1506
Intravitreal ranibizumab monotherapy to treat retinopathy of prematurity zone II, stage 3 with plus disease.
Menke MN, Framme C, Nelle M, Berger MR, Sturm V, Wolf S.
BMC Ophthalmol 2015;15:20
Predictors of prognosis and treatment outcome in central retinal artery occlusion: local intra-arterial fibrinolysis vs. conservative treatment.
Pielen A, Pantenburg S, Schmoor C, Schumacher M, Feltgen N, Junker B, Callizo J, EAGLE Study Group.
Neuroradiology 2015;57(10):1055-1062
miR-145 is a promising therapeutic target to prevent corneal scarring.
Ratuszny D, Gras C, Bajor A, Börger AK, Pielen A, Börgel M, Framme C, Blasczyk R, Figueiredo C.
Hum Gene Ther 2015;26(10):698-707
Time-Resolved Ultra-High Resolution Optical Coherence Tomography for Real-Time Monitoring of Selective Retina Therapy.
Steiner P, Ebneter A, Berger LE, Zinkernagel M, Povazay B, Meier C, Kowal JH, Framme C, Brinkmann R, Wolf S, Sznitman R.
Invest Ophthalmol Vis Sci 2015;56(11):6654-6662
Reviews
Feltgen N, Pielen A. Retinal vein occlusion: therapy of retinal vein occlusion. Ophthalmologe 2015;112(8):695-706
Editorships
Framme C[ed]: The macular edema. 2nd, revised editionBremen: UNI-MED, 2015. 128 P.
Reinhard T, Bornfeld N, Framme C[Eds]: Handbook of Ophthalmology 2015/2016: OphthalmoUpdate 2015. wiesbaden: Med Publico GmbH, 2015. 430 p.: Ill.
Book contribution/monograph
Framme C. Diabetic retinopathy. In: Reinhard T, Bornfeld N, Framme C [Eds:] Handbook of Ophthalmology 2015/2016: OphthalmoUpdate 2015. Wiesbaden: Med Publico GmbH, 2015.
Pielen A, Feltgen N. The retinal vein occlusion. In: Framme C [ed:] The macular edema. 2nd, revised editionBremen: UNIMED, 2015. PP. 53-62
Seidensticker F, Aghdam KA, Framme C. Central serous chorioretinopathy. In: Lois N, Forrester JV[eds]: Fundus autofluorescence. SecoPhiladelphia: Wolters Kluwer, 2016. p. 337-343
Scholarships
Pielen, Amelie (Dr. med.): Habilitation funding as part of the MHH's Ellen Schmidt Program 2014/2015.
Bajor, Anna (Dr. med.): Ina-Pichlmayr Mentoring Program of the MHH.
Volkmann, Ingo (Dr. med.): Research funding from the Geschwister Freter Foundation for the project: Identification of microRNAs in vitreous fluid during vitrectomy in patients with amotio retinae or proliferative diabetic retinopathy.
Scientific awards
Volkmann, Ingo (Dr. med.): Doctoral Prize of the MHH for the work: MicroRNA-Mediated Epigenetic Silencing of Sirtuin1 Contributes to Impaired Angiogenic Responses.
Akman, Stella: Poster prize of the German Ophthalmological Society (DOG): Epidemiology and therapy of retinopathy of prematurity requiring treatment - the Hannover data in the Retina.net-ROP registry.
Further research activities
Framme, Carsten (Prof. Dr. med., MBA): Member of the editorial board of the journal Der Ophthalmologe; member of the scientific advisory board of the journal Klinische Monatsblätter für Augenheilkunde.
Pielen, Amelie (Dr. med.): Associate Editor of Acta Ophthalmologica; Member of the Clinical Trials Working Group.
Original publications
Switch of anti-VEGF agents is an option for nonresponders in the treatment of AMD.
Ehlken C, Jungmann S, Böhringer D, Agostini HT, Junker B, Pielen A. Eye (Lond) 2014;28(5):538-545- IF 1,897
Full text: http://dx.doi.org/10.1038/eye.2014.64
A signature of circulating microRNAs differentiates takotsubo cardiomyopathy from acute myocardial infarction.
Jaguszewski M, Osipova J, Ghadri JR, Napp LC, Widera C, Franke J, Fijalkowski M, Nowak R, Fijalkowska M, Volkmann I, et al. Eur Heart J. 2014 Apr;35(15):999-1006.
Effect of Homatropine eye drops on pain after photorefractive keratectomy: A pilot study
Joshaghani M, Nazari H, Ghasemi Falavarjani K, Shokrollahi S, Jafar Ghaempanah M, Abri Aghdam K, Mirbolouk Jalali Z. Saudi J Ophthalmol 2013;27(2):83-85
Full text: http://dx.doi.org/10.1016/j.sjopt.2012.07.003
Intravitreal Ranibizumab versus Isovolemic Hemodilution in the Treatment of Macular Edema Secondary to Central Retinal Vein Occlusion: Twelve-Month Results of a Prospective, Randomized, Multicenter Trial.
Kreutzer TC, Wolf A, Dirisamer M, Strauss RW, Foerster P, Feltgen N, Pielen A, Hattenbach LO, Kampik A, Priglinger SG. Ophthalmologica 2014:DOI: 10.1159/000369566- IF 1,867
Full text: http://dx.doi.org/10.1159/000369566
Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure.
Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, et al. Circ Res. 2014 May;114(10):1569-75.
Vascular importance of the miR-212/132 cluster.
Kumarswamy R, Volkmann I, Beermann J, Napp LC, Jabs O, Bhayadia R, et al. Eur Heart J. 2014 Sep 12
Retinal layer measurements after successful macula-off retinal detachment repair using optical coherence tomography
Menke MN, Kowal JH, Dufour P, Wolf-Schnurrbusch UE, Ceklic L, Framme C, Wolf S. Invest Ophthalmol Vis Sci 2014;55(10):6575-6579- IF 3,661
Full text: http://dx.doi.org/10.1167/iovs.14-14412
Age-Related Contractile Force of Human Vessels.
Muller-Schweinitzer E, Glusa E, Schilling A, Kern T, Reineke DC, Eckstein FS, Grapow MTR. Angiology 2014;2(1):122
Full text: http://dx.doi.org/10.4172/2329-9495.1000122
Diabetes-associated microRNAs in pediatric patients with type 1 diabetes mellitus: a cross-sectional cohort study.
Osipova J, Fischer D-C, Dangwal S, Volkmann I, Widera C, Schwarz K, et al. J Clin Endocrinol Metab. 2014 Jun;jc20133868.
Intra- and postoperative risks and complications of small-gauge (23-G) versus conventional (20-G) vitrectomy for macular surgery.
Pielen A, Guerra NI, Böhringer D, Junker B, Bühler AD, Stahl A, Agostini HT, Ehlken C. Eur J Ophthalmol 2014;24(5):778-785- IF 1,058
Full text: http://dx.doi.org/10.5301/ejo.5000461
Ranibizumab for Branch Retinal Vein Occlusion Associated Macular Edema Study (RABAMES): six-month results of a prospective randomized clinical trial.
Pielen A, Mirshahi A, Feltgen N, Lorenz K, Korb C, Junker B, Schaefer C, Zwiener I, Hattenbach LO, the RABAMES Study Group. Acta Ophthalmol 2014:DOI: 10.1111/aos.12488- IF 2,512
Full text: http://dx.doi.org/10.1111/aos.12488
Recommendations of the DOG on publication regulations in multicenter studies.
Pielen A, Wilhelm B, Holz F. Ophthalmologe 2014;111(5):498-499- IF 0.719
Full text: http://dx.doi.org/10.1007/s00347-014-3080-6
Recommendations of the DOG on publication regulations in multicenter studies.
Pielen A, Wilhelm B, Holz F, for the Working Group Clinical Study Centers of the DOG. Klin Monbl Augenheilkd 2014;231(6):651-652- IF 0.665
Full text: http://dx.doi.org/10.1055/s-0034-1368482
Sanjari MS, Shahraki K, Nekoozadeh S, Tabatabaee SM, Shahraki K, Abri Aghdam K. J Ophthalmic Vis Res 2014;9(3):291-295
Full text: http://dx.doi.org/10.4103/2008-322X.143355
Assessment of beta-zone peripapillary atrophy by optical coherence tomography and scanning laser ophthalmoscopy imaging in glaucoma patients.
Seidensticker F, Reznicek L, Mann T, Hübert I, Kampik A, Ulbig M, Hirneiss C, Neubauer AS, Kernt M. Clin Ophthalmol 2014;8:1233-1239
Full text: http://dx.doi.org/10.2147/OPTH.S55751
Treatment of exudative age-related macular degeneration with a designed ankyrin repeat protein that binds vascular endothelial growth factor: a phase I/II study
Souied EH, Devin F, Mauget-Faysse M, Kolar P, Wolf-Schnurrbusch U, Framme C, Gaucher D, Querques G, Stumpp MT, Wolf S, MP0112 Study Group. Am J Ophthalmol 2014;158(4):724-732.e2- IF 4,021
Full text: http://dx.doi.org/10.1016/j.ajo.2014.05.037
Editorships
Framme C [ed]: Study results on ranibizumab - retinal vein occlusion (RVV) and pathologic myopia (PM) . Stuttgart: Thieme, 2014. (Thieme Drug Report ; 9(1))
Framme C [ed]: Aflibercept - Therapy of neovascular AMD with aflibercept: case reports and experience reports. Stuttgart: Thieme, 2014. 50 pp. : ill., graph. Fig. (Thieme Case Report ; 6(4))
Book contribution/monograph
Framme C. Diabetic retinopathy. In: Reinhard T [ed:] Handbook of Ophthalmology 2014/2015 / OphthalmoUpdate 2014. Wiesbaden: Med Publico, 2014. p. ch. 17
Dissertations
Janzen, Lea (Dr. med. dent.): Retrospective, observational study to assess the efficacy of anti-VEGF therapy with Lucentis in patients with exudative age-related macular degeneration (AMD)
MHH-Signature: D 79674
Case Report
Kobeleva X, Wegner F, Brunotte I, Dadak M, Dengler R, Stangel M. Varicella zoster-associated retinal and central nervous system vasculitis in a patient with multiple sclerosis treated with natalizumab. J Neuroinflammation 2014;11:19- IF 4,902
Full text: http://dx.doi.org/10.1186/1742-2094-11-19
Other
Abri Aghdam KA, Framme C. Ryan's Retinal Imaging and Diagnostics. Graefe's Archive for Clinical and Experimental Ophthalmology 2014:1-1- IF 2,333
Full text: http://dx.doi.org/10.1007/s00417-014-2863-4
Original publications
Developing an in situ nanosuspension: A novel approach towards the efficient administration of poorly soluble drugs at the anterior eye.
Luschmann C, Tessmar J, Schoeberl S, Strauss O, Framme C, Luschmann K, Goepferich A.
Eur J Pharm Sci. 2013 Jul 20;50(3-4):385-392. doi: 10.1016/j.ejps.2013.07.002. [Epub ahead of print]
Long-term intraocular pressure changes in patients with neovascular age-related macular degeneration treated with ranibizumab.
Menke MN, Salam A, Framme C, Wolf S.
Ophthalmologica. 2013;229(3):168-72. doi: 10.1159/000346397. Epub 2013 Mar 16.
Mobility experiments with microrobots for minimally invasive intraocular surgery.
Ullrich F, Bergeles C, Pokki J, Ergeneman O, Erni S, Chatzipirpiridis G, Pané S, Framme C, Nelson BJ.
Invest Ophthalmol Vis Sci. 2013 Apr 23;54(4):2853-63. doi: 10.1167/iovs.13-11825.
Three-year results of visual outcome with disease activity-guided ranibizumab algorithm for the treatment of exudative age-related macular degeneration.
Lala C, Framme C, Wolf-Schnurrbusch UE, Wolf S.
Acta Ophthalmol. 2013 Sep;91(6):526-30. doi: 10.1111/j.1755-3768.2012.02457.x. Epub 2012 Jun 14.
Semaphorin 3F forms an anti-angiogenic barrier in outer retina.
Buehler A, Sitaras N, Favret S, Bucher F, Berger S, Pielen A, Joyal JS, Juan AM, Martin
G, Schlunck G, Agostini HT, Klagsbrun M, Smith LE, Sapieha P, Stahl A.
FEBS Lett. 2013 Apr 18. pii: S0014-5793(13)00293-7. doi: 10.1016/j.febslet.2013.04.008. [Epub ahead of print]
Bilateral serous retinal detachment.
Gundlach E, Junker B, Gross N, Hansen LL, Pielen A.
Br J Ophthalmol. 2013 Apr 23 [Epub ahead of print] No abstract available. PMID:23613507
Cathepsin proteases promote angiogenic sprouting and laser-induced choroidal neovascularization in mice.
Bühler A, Berger S, Werner F, Martin G, Han H, Vierkotten S, Pielen A, Boehringer D, Schlunck G, Fauser S, Agostini HT, Reinheckel T, Stahl A.
Exp Eye Res. 2013 Jun 22. doi:pii: S0014-4835(13)00155-3. 10.1016/j.exer.2013.06.014. [Epub ahead of print]
Efficacy and Safety of Intravitreal Therapy in Macular Edema Due to Branch and Central Retinal Vein Occlusion: a Systematic Review.
Pielen A, Feltgen N, Isserstedt C, Callizo J, Junker B, Schmucker C.
2013) PLoS ONE 8(10): e78538. doi:10.1371/journal.pone.0078538
Porcine corneal cell culture models for studying epidemic keratoconjunctivitis.
Ramke M, Lam E, Meyer M, Knipper A, Heim A.
Mol Vis 2013;19:614-622
Book contributions
Framme C. Myopic macular degeneration and myopic CNV. In: Diagnosis and therapy of pathologic myopia. UNI-MED Bremen. 2013, pp. 36-41. ed. Maier
Original publications
Behavior of SD-OCT-detected hyperreflective foci in the retina of anti-VEGF-treated patients with diabetic macular edema.
Framme C, Schweizer P, Imesch M, Wolf S, Wolf-Schnurrbusch U.
Invest Ophthalmol Vis Sci. 2012 Aug 24;53(9):5814-8. doi: 10.1167/iovs.12-9950.
[Adapted and standardized patient management in the treatment of neovascular AMD in the outpatient setting of a university eye hospital].
Framme C, Wolf-Schnurrbusch UE, Lobsiger H, Bayer S, Wolf S.
Klin Monbl Augenheilkd. 2012 Aug;229(8):812-21. doi: 10.1055/s-0031-1299405. Epub 2012 May 21. review. German.
Acute visual loss after preoperative embolization of an ethmoidal metastasis.
Hufendiek K, Hufendiek K, Finkenzeller T, Helbig H, Framme C.
Int Ophthalmol. 2012 Apr;32(2):165-9. doi: 10.1007/s10792-012-9525-5. Epub 2012 Feb 16.
[Heterogeneity of costs and performance for penetrating eye injuries and suturing amniotic membranes under DRG conditions : Analysis of case constellations of the G-DRG C01B of the Regensburg University eye clinic].
Franz D, Mrosek M, Mrosek S, Helbig H, Framme C.
Ophthalmologe. 2012 Jan;109(1):59-67. doi: 10.1007/s00347-011-2467-x. German.
Intraocular pressure changes following 20G pars-plana vitrectomy.
Framme C, Klotz S, Wolf-Schnurrbusch UE, Wiedemann P, Wolf S.
Acta Ophthalmol. 2012 Dec;90(8):744-9. doi: 10.1111/j.1755-3768.2011.02251.x. Epub 2011 Sep 28.
Retinal complications after damaging the vitreolenticular barrier.
Framme C, Wolf S.
Ophthalmologica. 2012;227(1):20-33. doi: 10.1159/000330421. Epub 2011 Sep 22. review.'
Book contributions
Framme C. Diabetic retinopathy. In: Handbook of Ophthalmology 2012/2013. Springer-Verlag. ISBN 978-3-86302-058-3 ed. Reinhard, Bornfeld, Framme
Framme C. (ed.) et al. The macular edema. UNI-MED Bremen. 1st edition. ISBN 978-3-8374-1393-9