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Projects
Subject areas
The content of the DigiStrucMed projects on offer can be divided into four subject areas in terms of their areas of application/objectives:
- Tools and technologies for physicians. Digitization processes in medicine, such as electronic medical history tools, the introduction of structured data collection or digital communications in studies, are to be compared with analogue processes or new methods are to be developed for evaluating health-relevant data. In addition, decision support systems are to be developed and evaluated through the networking of already digitized data and on the basis of suitable algorithms.
- Tools and technologies for patients: Projects in the second thematic complex deal with the development of technologies that are intended to support patients in being able to make informed decisions (informed patient) and, in a second focus, technologies that are intended to simplify patient follow-up and enable home monitoring, for example.
- Analysis technologies for diagnostics and treatment: Analysis technologies for laboratory and imaging diagnostics, but also for predicting therapy effectiveness and resistance, are being developed and evaluated for progression assessment and prevention. These can be implemented using artificial intelligence methods (e.g. image analysis based on neural networks) or focus on big data, databases and data mining.
- Robotics and assistance systems: The possible applications of robotic and assistance systems in Clinical Departments and Nursing are being investigated.
ID | Title | Project Leader Medicine | Project Leader Informatics |
P01 | Development of a bioinformatical tool to predict clinical responses to CFTR modulator therapy by integrating microbial metagenomics, inflammatory cell transcriptomics and secretomics | Prof. Dr. med. Anna-Maria Dittrich Pediatric Pneumology, Allergy and Neonatology, Hannover Medical School | Prof. Dr. Dipl.-Ing. Wolfgang Nejdl Institute of Data Science, L3S Research Institute, Leibniz University Hannover |
P02 | Automation of ISHAK Scoring: Machine Based Development of Unsupervised Liver Fibrosis Index | PD Dr. Nagoud Schukfeh Department of Pediatric Surgery, Hannover Medical School | Prof. Dr. Dr. Andrea Schenk Fraunhofer Institute for Digital Medicine MEVIS |
P03 | Large language models to support patients with hereditary breast and ovarian cancer: opinion research, development of quality standards and implementation in a mobile app | Dr. rer. nat. Beate Vajen Department of Human Genetics, Hannover Medical School | Dr. rer. nat. Dominik Wolff Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
P04 | Structured Digital Learning and AI Optimization for Heart Failure Education | Prof. Dr. med. David Duncker Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School | Prof. Dr. Dr. Maria-Esther Vidal Data Science Institute, Leibniz University of Hannover |
P05 | Analysis of broad interdisciplinary data sets from patients with transthyretin amyloidosis by classical statistical and advanced machine-learning methods for improved prediction of disease progression and outcomes | Prof. Dr. med. Udo Bavendiek Department of Cardiology and Angiology, Hannover Medical School Amyloidosis Center Lower Saxony, Hannover Medical School | Dr. Matthias Gietzelt Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
P06 | CLARA - Cognitive Language Assistant and Retrieval Aid | PD Dr. med. Hans Worthmann Department of Neurology, Hannover Medical School | Dipl. Wirt.-Inf. Mareike Schulze Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
P07 | Can the machine detect information we cannot? Developing an algorithm that can diagnose patients with functional tic-like movement disorder using machine learning. | Prof. Dr. Kirsten Müller-Vahl Clinic of Psychiatry, Social Psychiatry and Psychotherapy, Hannover Medical School | Prof. Dr. Dr. Lars Schmidt-Thieme Information Systems and Machine Learning Lab, University of Hildesheim |
P08 | Establishing Oxford Nanopore Sequencing technology as a rapid method for karyotyping in clinical practice | Prof. Dr. Dr. Michael Heuser Department of Internal Medicine IV, University Hospital Halle (Saale) | Prof. Dr. Matthias Müller-Hannemann Institute for Computer Science, Department Data Structures and Efficient Algorithms Faculty of Natural Sciences III, Halle (Saale)
|
ID | Project title | Project leader | Cooperation partner |
| P01 | Computerized interpretation of fetal heart rate during labor including clinical parameters | PD Dr. Lars Brodowski
| Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
| P02 | Development, feasibility and usability of a generic and secure application backed by a large language model with focus on patient education in patients with implantable defibrillators and heart failure | Prof. Dr. Dr. David Duncker Hannover Heart Rhythm Center Department oft Cardiology and Angiology Hannover Medical School | Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
| P03 | Algorithm development using machine learning to distinguish between tics and functional tic-like movements in videos | Prof. Dr. Dr. Kirsten Müller-Vahl Clinic of Psychiatry, Social Psychiatry and Psychotherapy Hannover Medical School | Institute for Information Processing, Leibniz Universität Hannover Peter L. Reichertz Institute for Medical Informatics, TU Braunschweig and Hannover Medical School |
| P04 | User-independent AI-based MRI analysis of hepatobiliary function in patients with primary sclerosing cholangitis (PSC) | Prof. Dr. Dr. Kristina Ringe Department of Diagnostic and Interventional Radiology Hannover Medical School | Fraunhofer Institute for Digital Medicine MEVIS |
| P05 | Individualizing HCC surveillance based on an integrative systems medicine approach | Prof. Dr. Dr. Markus Cornberg Centre for Individualised Infection Medicine (CiiM), Hannover, Dept. of Gastroenterology, Hepatology and Endocrinology Hannover Medical School | Division Data Science in Biomedicine Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
| P06 | Implementation of an AI-supported mental health app in psychocardiology | Prof. Dr. Dr. Kai G. Kahl Department of Psychiatry, Social Psychiatry and Psychotherapy Hannover Medical School | Institute for Information Systems |
| P07 | Identification of biomarkers in hepatocellular carcinoma patients by combining advanced imaging techniques with machine learning approaches | PD Dr. Anna Saborowski Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School | Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
| P08 | Digital Twin for predicting road traffic injuries | Prof. Dr. Dr. Thomas M. Deserno Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School | Clinical Department of Trauma Surgery Hannover Medical School |
| P09 | Fibromyalgia Rheumatica and Digital Pain Drawing (FibRDraw) | Prof. Dr. Dr. Georg Behrens Department of Rheumatology and Immunology Hannover Medical School | Institute for Information Engineering, Ostfalia University of Applied Sciences Department of Psychosomatics and Psychotherapy |
| P10 | Evaluation of the clinical utility of wearable fitness tracking devices to predict liver related outcomes of patients with liver cirrhosis | Prof. Dr. Dr. Benjamin Maasoumy Department of Gastroenterology, Hepatology, Infectious Diseases and Endocrinology Hannover Medical School | Division Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School Trauma Department, Orthogeriatric Unit, Hannover Medical School |
ID | Project title | Project leader | Cooperation partner |
P01 | Heartbeat Measurements on eScooters for Continuous Health Monitoring | Prof. Dr. rer. nat. Dipl.-Ing. Thomas M. Deserno | Hannover Heart Rhythm Center, Department of Cardiology and Angiology, Hannover Medical School |
P02 | ldentification of risk factors for postoperative acute kidney injury after non-cardiac surgery | PD Dr. med. Thomas Stüber | Department of Nephrology and Hypertension, Hannover Medical School Peter l. Reichertz Institute for Medical lnformatics ofTU Braunschweig and MHH, Hannover Medical School |
P03 | Delineating immune escape mechanisms in acute myeloid leukemia through single-cell analyses | Prof. Dr. med. Michael Heuser | Pediatric Hematology and Oncology, Hannover Medical School Division Data Science in Biomedicine, Peter L. Reichertz Institute for Medical Informatics, TU Braunschweig and Hannover Medical School |
P04 | Ambulatory assessment of online shopping activities in patients with compulsive buying-shopping disorder | Prof. Dr. med. Dr. phil. Astrid Müller | Faculty III - Media, Information and Design, Hochschule Hannover - University of Applied Sciences and Arts |
P06 | Development of a bioinformatic tool to predict clinical responses to CFTR modulator therapy by integrating microbial metagenomics, inflammatory cell transcriptomics and secretomics | Prof. Dr. med. Anna-Maria Dittrich | Research Core Unit Genomics, Hannover Medical School |
P07 | Towards AI-based registration for advanced functional lung imaging | Prof. Dr. med. Jens Vogel-Claussen | |
P08 | Unsupervised identification of prognostic cell type signatures for CNS infiltration in ALL | Prof. Dr. med. Martin Stanulla | German Center for Lung Research Center, Hannover Medical School |
P09 | Inter-hospital Transfer for Endovascular Treatment in Acute Stroke Care using the Smart Application "VIZ" | PD Dr. med. Hans Worthmann | Peter L. Reichertz Institute for medical informatics of TU Braunschweig and MHH |
P10 | Characterization of Ambulatory Blood Pressure Monitoring (ABPM) Profiles Using Data Mining and Machine Learning in Healthy and Diseased Children | Prof. Dr. med. Anette Melk, PhD Prof. Dr. Dr. Steffen Oeltze-Jafra Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School | Center of Pediatric and Adolescent Medicine, University Hospital Heidelberg |
P11 | AI-based image analysis in pediatric echocardiography to improve the monitoring of relevant parameters in children with pulmonary hypertension | Dr. Mohamed Yaseen Jabarulla Dr. med. Theodor Uden Pediatric Cardiology and Pediatric Intensive Care Medicine | - |
P12 | Is blended treatment with a WebApp-based therapy of mental disorders after life-threatening cardiac events more effective compared to non-blended treatment? | Prof. Dr. med. Kai G. Kahl | Fkt. IV, Department of Informatics, Hanover University of Applied Sciences and Arts |
Project title | Project leader | Cooperation partner |
| P01 - (Semi-) Automated procedures to find arguments for bioethical analyses | Prof. Dr. Sabine Salloch Institute of Ethics, History and Philosophy of Medicine | Institute for Information Systems Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
| P02 - Tracking fake papers in scientific journals | Prof. Dr. Dr. Roland Seifert Institute of Pharmacology, Hannover Medical School | Peter L. Reichertz Institute for Medical Informatics, TU Braunschweig and Hannover Medical School |
P03 - Deciphering long-term consequences of HCV infection after viral elimination (Long-HepC) using Omics Integration | Prof. Dr. Dr. Markus Cornberg Centre for Individualized Infection Medicine (CiiM); | Peter L. Reichertz Institute for Medical Informatics of the TU Braunschweig and the Hannover Medical School |
| P04 - Development and evaluation of an app to support patients with hereditary breast and ovarian cancer after genetic counseling | PD Dr. Anke K. Bergmann Department of Human Genetics, Hannover Medical School Prof. Dr. Dr. Steffen Oeltze-Jafra Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School | Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
| P05 - Predictive immune biomarkers in renal cancer: Compare immune landscape of tumors in native and transplanted (immunocompromised) kidneys | Prof. Dr. Jan Hinrich Bräsen Institute of Pathology | Technical University of Braunschweig; Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
P06 - Development of prediction models for postoperative renal failure in children after heart surgery using the heart-lung machine | PD Dr. Martin Böhne Pediatric Cardiology and Intensive Care Medicine, Hannover Medical School | Peter L. Reichertz Institute for Medical Informatics of TU Braunschweig and Hannover Medical School |
| P07 - Development of Translational Scores for a Quantitative and Time-Dependent Assessment of Disease Severity in Patients | Prof. Dr. André Bleich Laboratory Animal Science, Hannover Medical School | Department of Pediatric Kidney, Liver and Metabolic Diseases, Hannover Medical School |
| P08 - Clinical evaluation with a WebApp-based therapy of mental disorders after life-threatening cardiac events | Prof. Dr. Kai G. Kahl Department of Psychiatry, Social Psychiatry and Psychotherapy | Department of Cardiology and Angiology Department of Computer Science, Hanover University of Applied Sciences and Arts |
| P09 - Next generation Flow-Cytometry to quantify and characterize the leukemic stem cell population in acute myeloid leukemia | Dr. Dr, Adrian Schwarzer Hematology, Hemostasis, Oncology and Stem Cell Transplantation | Peter L. Reichertz Institute for Medical Informatics Clinic of Pediatric Hematology, Hannover Medical School |
| P10 - Towards identifying genetic determinants of antibiotic resistance in clinical Pseudomonas aeruginosa, Escherichia coli and Klebsiella pneumoniae isolates | Prof. Dr. Dr. Susanne Häußler Institute for Molecular Bacteriology, TWINCORE | Helmholtz Center for Infection Research (HZI) |
Project title | Project leader | Cooperation partner |
P03 - Development of an AI-based algorithm to predict kidney injury in stem cell transplant patients | Dr. Gernot Beutel Hematology, Hemostaseology, Oncology and Stem Cell Transplantation Hannover Medical School | Braunschweig Clinical Department of Nephrology, Rheumatology, Blood Purification Procedures, Prof. Dr. Dr. Jan T. Kielstein |
P06 - Next generation flow cytometry to detect minimal residual disease in acute myeloid leukemia | Dr. Dr. Adrian Schwarzer Hematology, Hemostaseology, Oncology and Stem Cell Transplantation Hannover Medical School | Peter L. Reichertz Institute of Medical Informatics |
P07 - The Inner Clock - Introduction and use of a smart communication tool to improve the emergency care of stroke patients | PD Dr. Hans Worthmann Neurology, Neuroradiology Hannover Medical School | Hanover University of Applied Sciences and Arts, Peter L. Reichertz Institute of Medical Informatics |
P08 - Determination of reference values of regional ventilation from CT scans of the lungs | Prof. Dr. Hoen-oh Shin Diagnostic and Interventional Radiology Hannover Medical School | Fraunhofer MEVIS Institute for Digital Medicine, Bremen |
P09 - WebApp-based prevention and therapy of adjustment disorder after life-threatening cardiac events - the "AD-support" study | Prof. Dr. Kai G Kahl / Dr. Ivo-Aleksander Heitland Psychiatry, Social Psychiatry and Psychotherapy Hannover Medical School | Leibniz University Hannover, Information Systems and Management Institute (ISMI) |
P10 - Reducing the socio-economic burden for rare disease patients using artificial intelligence (AI) | Prof. Dr. Annette Doris Wagner Renal and hypertensive diseases Hannover Medical School | University Hospital Marburg, Institute for Artificial Intelligence in Medicine, Ada Health GmbH |
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